A unified model for regulating lipoprotein lipase activity

Trends Endocrinol Metab. 2024 Mar 23:S1043-2760(24)00045-6. doi: 10.1016/j.tem.2024.02.016. Online ahead of print.ABSTRACTThe regulation of triglyceride (TG) tissue distribution, storage, and utilization, a fundamental process of energy homeostasis, critically depends on lipoprotein lipase (LPL). We review the intricate mechanisms by which LPL activity is regulated by angiopoietin-like proteins (ANGPTL3, 4, 8), apolipoproteins (APOA5, APOC3, APOC2), and the cAMP-responsive element-binding protein H (CREBH). ANGPTL8 functions as a molecular switch, through complex formation, activating ANGPTL3 while deactivating ANGPTL4 in their LPL inhibition. The ANGPTL3-4-8 model integrates the roles of the aforementioned proteins in TG partitioning between white adipose tissue (WAT) and oxidative tissues (heart and skeletal muscles) during the feed/fast cycle. This model offers a unified perspective on LPL regulation, providing insights into TG metabolism, metabolic diseases, and therapeutics.PMID:38521668 | DOI:10.1016/j.tem.2024.02.016
Source: Trends in Endocrinology and Metabolism: TEM - Category: Endocrinology Authors: Source Type: research