Trends in Endocrinology and Metabolism: TEM This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Ion homeostasis in diabetic kidney disease
Trends Endocrinol Metab. 2023 Oct 23:S1043-2760(23)00211-4. doi: 10.1016/j.tem.2023.09.009. Online ahead of print.ABSTRACTThe complications of type 2 diabetes are a major global public health problem with high incidence and mortality, affecting almost all individuals with diabetes worldwide. Diabetic kidney disease (DKD) is one such primary complication and has become a leading cause of end-stage renal disease in patients with diabetes. Progression from diabetes to DKD is a complex process typically involving multiple mechanisms. Recent remarkable clinical benefits of sodium-glucose cotransporter 2 (SGLT2) inhibitors in di...
Source: Trends in Endocrinology and Metabolism: TEM - October 25, 2023 Category: Endocrinology Authors: Hongtu Hu Wei Liang Guohua Ding Source Type: research

The gut-Snhg9 interplay as a new path to metabolic health
Trends Endocrinol Metab. 2023 Oct 23:S1043-2760(23)00216-3. doi: 10.1016/j.tem.2023.10.003. Online ahead of print.ABSTRACTParsing the intricate interplay between gut microbiota, gene modulation, and host metabolism remains challenging. Wang et al. employed diverse methods to uncover how the gut microbiota reshapes intestinal lipid metabolism through the lncRNA Snhg9, underscoring the value of systems biology approaches in dissecting host-microbiome relationships involved in metabolic disorders.PMID:37880053 | DOI:10.1016/j.tem.2023.10.003 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - October 25, 2023 Category: Endocrinology Authors: Jie Chen Xian Chen Jiangtao Gao Source Type: research

The ticking of aging clocks
Trends Endocrinol Metab. 2023 Oct 23:S1043-2760(23)00196-0. doi: 10.1016/j.tem.2023.09.007. Online ahead of print.ABSTRACTComputational models that measure biological age and aging rate regardless of chronological age are called aging clocks. The underlying counting mechanisms of the intrinsic timers of these clocks are still unclear. Molecular mediators and determinants of aging rate point to the key roles of DNA damage, epigenetic drift, and inflammation. Persistent DNA damage leads to cellular senescence and the senescence-associated secretory phenotype (SASP), which induces cytotoxic immune cell infiltration; this furt...
Source: Trends in Endocrinology and Metabolism: TEM - October 25, 2023 Category: Endocrinology Authors: Jing-Dong J Han Source Type: research

Hallmarks of the metabolic secretome
Trends Endocrinol Metab. 2023 Oct 14:S1043-2760(23)00195-9. doi: 10.1016/j.tem.2023.09.006. Online ahead of print.ABSTRACTThe identification of novel secreted factors is advancing at an unprecedented pace. However, there is a critical need to consolidate and integrate this knowledge to provide a framework of their diverse mechanisms, functional significance, and inter-relationships. Complicating this effort are challenges related to nonstandardized methods, discrepancies in sample handling, and inconsistencies in the annotation of unknown molecules. This Review aims to synthesize the rapidly expanding field of the metaboli...
Source: Trends in Endocrinology and Metabolism: TEM - October 16, 2023 Category: Endocrinology Authors: Saranya C Reghupaty Nicholas R Dall Katrin J Svensson Source Type: research