Cellotype-phenotype associations using 'organoid villages'

Trends Endocrinol Metab. 2024 Apr 3:S1043-2760(24)00063-8. doi: 10.1016/j.tem.2024.03.001. Online ahead of print.ABSTRACTEn masse phenotyping technology, using massively mosaic donor-derived cells and organoids, can offer enriched insights for cellotype-phenotype association in a cell-type-specific regulatory context. This emerging approach will help to discover biomarkers, inform genetic-epigenetic interactions and identify personalized therapeutic targets, offering hope for precision medicine against highly heterogeneous metabolic diseases.PMID:38575442 | DOI:10.1016/j.tem.2024.03.001

Source: Trends in Endocrinology and Metabolism: TEM - April 4, 2024 Category: Endocrinology Authors: Masaki Kimura Takanori Takebe Source Type: research