Sensing mitochondrial DNA stress in cardiotoxicity
Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00165-0. doi: 10.1016/j.tem.2023.08.012. Online ahead of print.ABSTRACTCytoplasmic mitochondrial DNA (mtDNA) can trigger the interferon response to promote disease progression, but mtDNA sensing mechanisms remain elusive. Lei et al. have shown that Z-DNA binding protein1 (ZBP1) cooperates with cyclic GMP-AMP synthase (cGAS) to sense Z-form mtDNA and transmit mtDNA stress signals to promote diseases such as cardiotoxicity, providing an important piece of the mtDNA stress landscape.PMID:37673764 | DOI:10.1016/j.tem.2023.08.012 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - September 6, 2023 Category: Endocrinology Authors: Yang-Nan Ding Xiaoqiang Tang Source Type: research

Metabolic control by AMPK in white adipose tissue
Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00164-9. doi: 10.1016/j.tem.2023.08.011. Online ahead of print.ABSTRACTWhite adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new generation of direct, small-molecule activators. AMPK activation in WAT inhibits insulin-stimulated lipogenesis and in some situations also inhibits insulin-stimula...
Source: Trends in Endocrinology and Metabolism: TEM - September 6, 2023 Category: Endocrinology Authors: Olga G öransson Franziska Kopietz Mark H Rider Source Type: research

Pre-RNA splicing in metabolic homeostasis and liver disease
Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00160-1. doi: 10.1016/j.tem.2023.08.007. Online ahead of print.ABSTRACTThe liver plays a key role in sensing nutritional and hormonal inputs to maintain metabolic homeostasis. Recent studies into pre-mRNA splicing and alternative splicing (AS) and their effects on gene expression have revealed considerable transcriptional complexity in the liver, both in health and disease. While the contribution of these mechanisms to cell and tissue identity is widely accepted, their role in physiological and pathological contexts within tissues is just beginning to be appreciated. In thi...
Source: Trends in Endocrinology and Metabolism: TEM - September 6, 2023 Category: Endocrinology Authors: Andrew M Jobbins Sijia Yu Helen A B Paterson Hannah Maude Antonia Kefala-Stavridi Christian Speck In ês Cebola Santiago Vernia Source Type: research

Mechanisms and pathophysiology of SARS-CoV-2 infection of the adipose tissue
Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00163-7. doi: 10.1016/j.tem.2023.08.010. Online ahead of print.ABSTRACTObesity is an independent risk factor for severe COVID-19, yet there remains a lack of consensus on the mechanisms underlying this relationship. A hypothesis that has garnered considerable attention suggests that SARS-CoV-2 disrupts adipose tissue function, either through direct infection or by indirect mechanisms. Indeed, recent reports have begun to shed some light on the important role that the adipose tissue plays during the acute phase of infection, as well as mediating long-term sequelae. In this r...
Source: Trends in Endocrinology and Metabolism: TEM - September 6, 2023 Category: Endocrinology Authors: Jill Moser Marloes Emous Peter Heeringa Izabela A Rodenhuis-Zybert Source Type: research

Sensing mitochondrial DNA stress in cardiotoxicity
Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00165-0. doi: 10.1016/j.tem.2023.08.012. Online ahead of print.ABSTRACTCytoplasmic mitochondrial DNA (mtDNA) can trigger the interferon response to promote disease progression, but mtDNA sensing mechanisms remain elusive. Lei et al. have shown that Z-DNA binding protein1 (ZBP1) cooperates with cyclic GMP-AMP synthase (cGAS) to sense Z-form mtDNA and transmit mtDNA stress signals to promote diseases such as cardiotoxicity, providing an important piece of the mtDNA stress landscape.PMID:37673764 | DOI:10.1016/j.tem.2023.08.012 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - September 6, 2023 Category: Endocrinology Authors: Yang-Nan Ding Xiaoqiang Tang Source Type: research

Metabolic control by AMPK in white adipose tissue
Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00164-9. doi: 10.1016/j.tem.2023.08.011. Online ahead of print.ABSTRACTWhite adipose tissue (WAT) plays an important role in the integration of whole-body metabolism by storing fat and mobilizing triacylglycerol when needed. The released free fatty acids can then be oxidized by other tissues to provide ATP. AMP-activated protein kinase (AMPK) is a key regulator of metabolic pathways, and can be targeted by a new generation of direct, small-molecule activators. AMPK activation in WAT inhibits insulin-stimulated lipogenesis and in some situations also inhibits insulin-stimula...
Source: Trends in Endocrinology and Metabolism: TEM - September 6, 2023 Category: Endocrinology Authors: Olga G öransson Franziska Kopietz Mark H Rider Source Type: research

Pre-RNA splicing in metabolic homeostasis and liver disease
Trends Endocrinol Metab. 2023 Sep 4:S1043-2760(23)00160-1. doi: 10.1016/j.tem.2023.08.007. Online ahead of print.ABSTRACTThe liver plays a key role in sensing nutritional and hormonal inputs to maintain metabolic homeostasis. Recent studies into pre-mRNA splicing and alternative splicing (AS) and their effects on gene expression have revealed considerable transcriptional complexity in the liver, both in health and disease. While the contribution of these mechanisms to cell and tissue identity is widely accepted, their role in physiological and pathological contexts within tissues is just beginning to be appreciated. In thi...
Source: Trends in Endocrinology and Metabolism: TEM - September 6, 2023 Category: Endocrinology Authors: Andrew M Jobbins Sijia Yu Helen A B Paterson Hannah Maude Antonia Kefala-Stavridi Christian Speck In ês Cebola Santiago Vernia Source Type: research

Questioning PCOS phenotypes for reclassification and tailored therapy
Trends Endocrinol Metab. 2023 Sep 1:S1043-2760(23)00158-3. doi: 10.1016/j.tem.2023.08.005. Online ahead of print.ABSTRACTPrecise diagnoses are essential for defining appropriate treatments. This is particularly true for polycystic ovary syndrome (PCOS), whose phenotypical manifestations have recently suggested a possible diversity of etiological factors. PCOS is defined on the basis of gynecological and endocrinological alterations, but the patients often display considerable metabolic impairments, such as insulin resistance, that may worsen typical symptoms. The Rotterdam criteria fail to address this aspect, and the medi...
Source: Trends in Endocrinology and Metabolism: TEM - September 4, 2023 Category: Endocrinology Authors: Samuel Harry Myers Michele Russo Simona Dinicola Gianpiero Forte Vittorio Unfer Source Type: research

Questioning PCOS phenotypes for reclassification and tailored therapy
Trends Endocrinol Metab. 2023 Sep 1:S1043-2760(23)00158-3. doi: 10.1016/j.tem.2023.08.005. Online ahead of print.ABSTRACTPrecise diagnoses are essential for defining appropriate treatments. This is particularly true for polycystic ovary syndrome (PCOS), whose phenotypical manifestations have recently suggested a possible diversity of etiological factors. PCOS is defined on the basis of gynecological and endocrinological alterations, but the patients often display considerable metabolic impairments, such as insulin resistance, that may worsen typical symptoms. The Rotterdam criteria fail to address this aspect, and the medi...
Source: Trends in Endocrinology and Metabolism: TEM - September 4, 2023 Category: Endocrinology Authors: Samuel Harry Myers Michele Russo Simona Dinicola Gianpiero Forte Vittorio Unfer Source Type: research

Questioning PCOS phenotypes for reclassification and tailored therapy
Trends Endocrinol Metab. 2023 Sep 1:S1043-2760(23)00158-3. doi: 10.1016/j.tem.2023.08.005. Online ahead of print.ABSTRACTPrecise diagnoses are essential for defining appropriate treatments. This is particularly true for polycystic ovary syndrome (PCOS), whose phenotypical manifestations have recently suggested a possible diversity of etiological factors. PCOS is defined on the basis of gynecological and endocrinological alterations, but the patients often display considerable metabolic impairments, such as insulin resistance, that may worsen typical symptoms. The Rotterdam criteria fail to address this aspect, and the medi...
Source: Trends in Endocrinology and Metabolism: TEM - September 4, 2023 Category: Endocrinology Authors: Samuel Harry Myers Michele Russo Simona Dinicola Gianpiero Forte Vittorio Unfer Source Type: research

Wildfires and COVID-19: syndemic impact on maternal and child health
Trends Endocrinol Metab. 2023 Aug 30:S1043-2760(23)00162-5. doi: 10.1016/j.tem.2023.08.009. Online ahead of print.ABSTRACTThe prevailing COVID-19 pandemic and climate change-mediated wildfires can combine to impact maternal-child health, yet this connection remains understudied. To shape policies and design interventions to mitigate the combined effects of future global catastrophes, it is vital to holistically evaluate the impact of syndemics on maternal-child health.PMID:37658035 | DOI:10.1016/j.tem.2023.08.009 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - September 1, 2023 Category: Endocrinology Authors: Amita Bansal Nicolas Cherbuin Liana Leach Rebecca A Simmons Christopher J Nolan Source Type: research

Wildfires and COVID-19: syndemic impact on maternal and child health
Trends Endocrinol Metab. 2023 Aug 30:S1043-2760(23)00162-5. doi: 10.1016/j.tem.2023.08.009. Online ahead of print.ABSTRACTThe prevailing COVID-19 pandemic and climate change-mediated wildfires can combine to impact maternal-child health, yet this connection remains understudied. To shape policies and design interventions to mitigate the combined effects of future global catastrophes, it is vital to holistically evaluate the impact of syndemics on maternal-child health.PMID:37658035 | DOI:10.1016/j.tem.2023.08.009 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - September 1, 2023 Category: Endocrinology Authors: Amita Bansal Nicolas Cherbuin Liana Leach Rebecca A Simmons Christopher J Nolan Source Type: research

Unleashing ferroptosis for cancer therapy with warfarin
Trends Endocrinol Metab. 2023 Aug 28:S1043-2760(23)00161-3. doi: 10.1016/j.tem.2023.08.008. Online ahead of print.ABSTRACTFerroptosis holds promise for cancer therapy. A recent study by Yang et al. in Cell Metabolism reveals that VKORC1L1-mediated reduction of vitamin K inhibits ferroptosis and establishes a direct p53-VKORC1L1 link in its regulation. As warfarin can inhibit VKORC1L1, the study further underscores this drug's potential as a cancer therapy.PMID:37648560 | DOI:10.1016/j.tem.2023.08.008 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - August 30, 2023 Category: Endocrinology Authors: Xiaoguang Liu Li Zhuang Boyi Gan Source Type: research

The emerging role of bile acids in white adipose tissue
Trends Endocrinol Metab. 2023 Aug 29:S1043-2760(23)00155-8. doi: 10.1016/j.tem.2023.08.002. Online ahead of print.ABSTRACTThe effects of bile acids (BAs) on liver, enteroendocrine function, small intestine, and brown adipose tissue have been described extensively. Outside the liver, BAs in the peripheral circulation system represent a specific but underappreciated physiological compartment. We discuss how systemic BAs can be regarded as specific steroidal hormones that act on white adipocytes, and suggest the name 'bilokines' ('bile hormones') for the specific FXR/TGR5 receptor interaction in adipocytes. Some BAs and their...
Source: Trends in Endocrinology and Metabolism: TEM - August 30, 2023 Category: Endocrinology Authors: Andreas Schmid Thomas Karrasch Andreas Sch äffler Source Type: research

Unleashing ferroptosis for cancer therapy with warfarin
Trends Endocrinol Metab. 2023 Aug 28:S1043-2760(23)00161-3. doi: 10.1016/j.tem.2023.08.008. Online ahead of print.ABSTRACTFerroptosis holds promise for cancer therapy. A recent study by Yang et al. in Cell Metabolism reveals that VKORC1L1-mediated reduction of vitamin K inhibits ferroptosis and establishes a direct p53-VKORC1L1 link in its regulation. As warfarin can inhibit VKORC1L1, the study further underscores this drug's potential as a cancer therapy.PMID:37648560 | DOI:10.1016/j.tem.2023.08.008 (Source: Trends in Endocrinology and Metabolism: TEM)
Source: Trends in Endocrinology and Metabolism: TEM - August 30, 2023 Category: Endocrinology Authors: Xiaoguang Liu Li Zhuang Boyi Gan Source Type: research