RNAkines are secreted messengers shaping health and disease

Trends Endocrinol Metab. 2023 Dec 29:S1043-2760(23)00249-7. doi: 10.1016/j.tem.2023.12.004. Online ahead of print.ABSTRACTExtracellular noncoding RNAs (ncRNAs) have crucial roles in intercellular communications. The process of ncRNA secretion is highly regulated, with specific ncRNA profiles produced under different physiological and pathological circumstances. These ncRNAs are transported primarily via extracellular vesicles (EVs) from their origin cells to target cells, utilising both endocrine and paracrine pathways. The intercellular impacts of extracellular ncRNAs are essential for maintaining homeostasis and the pathogenesis of various diseases. Given the unique aspects of extracellular ncRNAs, here we propose the term 'RNAkine' to describe these recently identified secreted factors. We explore their roles as intercellular modulators, particularly in their ability to regulate metabolism and influence tumorigenesis, highlighting their definition and importance as a distinct class of secreted factors.PMID:38160178 | DOI:10.1016/j.tem.2023.12.004

Source: Trends in Endocrinology and Metabolism: TEM - December 30, 2023 Category: Endocrinology Authors: Jing Li Jingwen Fang Xiaohong Jiang Yujing Zhang Antonio Vidal-Puig Chen-Yu Zhang Source Type: research