Cirrhotic patients and older people.
Authors: Carrier P, Debette-Gratien M, Jacques J, Loustaud-Ratti V Abstract The global population is aging, and so the number of older cirrhotic patients is increasing. Older patients are characterised by a risk of frailty and comorbidities, and age is a risk factor for mortality in cirrhotic patients. The incidence of non-alcoholic fatty liver disease as an aetiology of cirrhosis is increasing, while that of chronic viral hepatitis is decreasing. Also, cirrhosis is frequently idiopathic. The management of portal hypertension in older cirrhotic patients is similar to that in younger patients, despite the greater ri...
Source: World Journal of Hepatology - October 12, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Hepatic flow is an intraoperative predictor of early allograft dysfunction in whole-graft deceased donor liver transplantation: An observational cohort study.
CONCLUSION: Intraoperative measurement of blood flow after reperfusion appears to be a predictor of EAD; Moreover, HAF should be considered a predictor of 30-d patient mortality. PMID: 31598193 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - October 12, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Hepatocellular carcinoma staging systems: Hong Kong liver cancer vs Barcelona clinic liver cancer in a Western population.
CONCLUSION: In a Western population, the general agreement between the two systems was 80.0%, although in BCLC-B cases the agreement was low, suggesting that some individuals could be candidates for the curative treatment recommended by the HKLC. The authors suggest that the BCLC system should be routinely employed, although for BCLC-B cases it should be associated with the HKLC system. PMID: 31602288 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - October 12, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Is porto sinusoidal vascular disease to be actively searched in patients with portal vein thrombosis?
In conclusion, even if it is still totally hypothetical, our point of view may have clinical consequences, especially when deciding to perform a liver biopsy in patients with a higher liver stiffness and suspending the anticoagulation in patients with PVT and no detectable prothrombotic factors. PMID: 31528244 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - September 19, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice.
CONCLUSION: Overall, these data suggest that chronic HFD consumption in mice can mimic pathophysiological and some microbial events observed in NAFLD patients. PMID: 31528245 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - September 19, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Impact of psychosocial comorbidities on clinical outcomes after liver transplantation: Stratification of a high-risk population.
CONCLUSION: Patients with certain psychosocial comorbidities had worse outcomes following liver transplantation. Further prospective and multi-center studies are warranted to properly determine guidelines for liver transplantation regarding this high-risk population. PMID: 31528246 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - September 19, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Outpatient telephonic transitional care after hospital discharge improves survival in cirrhotic patients.
CONCLUSION: CP provided OTTC had higher 6 mo survival compared to controls without a difference in RR. Use of RR to gauge quality of care provided during hospitalization or subsequent transitional care programs should be revisited. PMID: 31528247 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - September 19, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Fascioliasis presenting as colon cancer liver metastasis on 18F-fluorodeoxyglucose positron emission tomography/computed tomography: A case report.
CONCLUSION: Parasitic diseases, such as those caused by Fasciola hepatica, should be kept in mind in the differential diagnosis of primary or metastatic liver tumors, such as colorectal cancer liver metastasis, in patients living in endemic areas. PMID: 31528248 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - September 19, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Rise of sodium-glucose cotransporter 2 inhibitors in the management of nonalcoholic fatty liver disease.
Authors: Dokmak A, Almeqdadi M, Trivedi H, Krishnan S Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in the Western world. It is more prevalent in male gender, and with increasing age, obesity, and insulin resistance. Besides weight loss, there are limited treatment options. The use of anti-diabetic medications has been studied with mixed results. In this review, we discuss the use of anti-diabetic medications in the management of NAFLD with a specific focus on sodium-glucose cotransporter 2 inhibitors. We shed light on the evidence supporting their use in detail...
Source: World Journal of Hepatology - August 9, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Role of innovative 3D printing models in the management of hepatobiliary malignancies.
Authors: Bangeas P, Tsioukas V, Papadopoulos VN, Tsoulfas G Abstract Three-dimensional (3D) printing has recently emerged as a new technique in various liver-related surgical fields. There are currently only a few systematic reviews that summarize the evidence of its impact. In order to construct a systematic literature review of the applications and effects of 3D printing in liver surgery, we searched the PubMed, Embase and ScienceDirect databases for relevant titles, according to the PRISMA statement guidelines. We retrieved 162 titles, of which 32 met the inclusion criteria and are reported. The leading applicat...
Source: World Journal of Hepatology - August 9, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Epidemiology and outcomes of acute liver failure in Australia.
Authors: Hey P, Hanrahan TP, Sinclair M, Testro AG, Angus PW, Peterson A, Warrillow S, Bellomo R, Perini MV, Starkey G, Jones RM, Fink M, McClure T, Gow P Abstract BACKGROUND: Acute liver failure (ALF) is a life-threatening syndrome with varying aetiologies requiring complex care and multidisciplinary management. Its changing incidence, aetiology and outcomes over the last 16 years in the Australian context remain uncertain. AIM: To describe the changing incidence, aetiology and outcomes of ALF in South Eastern Australia. METHODS: The database of the Victorian Liver Transplant Unit was interrogated to ident...
Source: World Journal of Hepatology - August 9, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Spontaneous fungal peritonitis: Micro-organisms, management and mortality in liver cirrhosis-A systematic review.
CONCLUSION: This systematic review suggests that SFP in end stage liver disease patient is associated with high mortality both in the hospital and at 1-mo, and that antifungal therapy is currently underutilized. PMID: 31388401 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - August 9, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Wilson disease developing osteoarthritic pain in severe acute liver failure: A case report.
CONCLUSION: Patients with WD who develop ALF with an NWIS> 11 may survive after treatment with Zn and chelators, without liver transplantation, when they present with mild hyperbilirubinemia and stage ≤ II hepatic encephalopathy. Osteoarthritis symptoms may improve with long-term Zn and chelator therapy without correlation of liver function in WD. PMID: 31388402 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - August 9, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Dietary approach and gut microbiota modulation for chronic hepatic encephalopathy in cirrhosis.
Authors: Campion D, Giovo I, Ponzo P, Saracco GM, Balzola F, Alessandria C Abstract Hepatic encephalopathy (HE) is a common and serious neuropsychiatric complication of cirrhosis, acute liver failure, and porto-systemic shunting. HE largely contributes to the morbidity of patients with liver disease, severely affecting the quality of life of both patients and their relatives and being associated with poor prognosis. Its presentation is largely variable, manifesting with a broad spectrum of cognitive abnormalities ranging from subtle cognitive impairment to coma. The pathogenesis of HE is complex and has historicall...
Source: World Journal of Hepatology - July 13, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Outcomes of staged hepatectomies for liver malignancy.
Authors: Albati NA, Korairi AA, Hasan IA, Almodhaiberi HK, Algarni AA Abstract Liver malignancies are the fifth most common cause of death worldwide. Surgical intervention with curative intent is the treatment of choice for liver tumors as it provides long-term survival. However, only 20% of patients with metastatic liver lesions can be managed by curative liver resection. In most of the cases, hepatectomy is not feasible because of insufficient future liver remnant (FLR). Two-stage hepatectomy is advocated to achieve liver resection in a patient who is considered to not be a candidate for resection. Procedures of ...
Source: World Journal of Hepatology - July 13, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients.
CONCLUSION: Chronic PPI use in cirrhotic patients is associated with significantly higher average West Haven Criteria for HE compared to patients that do not use PPIs. PMID: 31293720 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - July 13, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Efficacy of long-term rifaximin treatment for hepatic encephalopathy in the Japanese.
CONCLUSION: Rifaximin therapy improves overt HE. The long-term use of rifaximin in the Japanese is effective and safe. PMID: 31293721 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - July 13, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Validation of modified albumin-bilirubin-TNM score as a prognostic model to evaluate patients with hepatocellular carcinoma.
Authors: Elshaarawy O, Alkhatib A, Elhelbawy M, Gomaa A, Allam N, Alsebaey A, Rewisha E, Waked I Abstract BACKGROUND: An ideal staging system for hepatocellular carcinoma (HCC) should rely on the hepatic reserve function and tumor burden. With the improvement in diagnostic and treatment strategies for HCC, in addition to recent treatment of viral hepatitis, finding a suitable assessment tool for hepatic reserve has become mandatory. AIM: To validate a recently proposed modified albumin-bilirubin-TNM (mALBI-T) grade as a prognostic model for patients with HCC in Egypt. METHODS: For patients diagnosed with HC...
Source: World Journal of Hepatology - July 13, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Risk factors for ribavirin treatment failure in Asian organ transplant recipients with chronic hepatitis E infection.
This study describes the outcome of HEV treatment in a transplant center in Singapore. AIM: To study the outcome of ribavirin treatment in a series of chronic HEV patients, and the cause of treatment failure. METHODS: We studied all of the transplant recipients who were diagnosed with HEV infection between 2012 to 2015. The outcome of therapy and virologic relapse are monitored for three years after the end of therapy. RESULTS: Ten transplant recipients (4 liver, 5 kidney, and 1 bone marrow transplantation) with positive HEV RNA were studied. Nine patients received at least 12 wk of ribavirin therapy, and the r...
Source: World Journal of Hepatology - July 13, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Roles of hepatic stellate cells in acute liver failure: From the perspective of inflammation and fibrosis.
Authors: Li J, Zhao YR, Tian Z Abstract Acute liver failure (ALF) usually results in hepatocellular dysfunction and coagulopathy and carries a high mortality rate. Hepatic stellate cells (HSCs) are famous for their role in liver fibrosis. Although some recent studies revealed that HSCs might participate in the pathogenesis of ALF, the accurate mechanism is still not fully understood. This review focuses on the recent advances in understanding the functions of HSCs in ALF and revealed both protective and promotive roles during the pathogenesis of ALF: HSC activation participates in the maintenance of cell attachment...
Source: World Journal of Hepatology - June 13, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Hepatitis C virus cure with direct acting antivirals: Clinical, economic, societal and patient value for China.
This article aims to provide a comprehensive evaluation on the value of effective, curative hepatitis C treatment from the clinical, economic, societal, and patient experience perspectives, with a focus on recent data from China, supplemented with other Asian and international experiences where China data are not available. PMID: 31183003 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - June 13, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Hepatitis C virus antigens enzyme immunoassay for one-step diagnosis of hepatitis C virus coinfection in human immunodeficiency virus infected individuals.
CONCLUSION: The modified HCV-Ags EIA has a lower detection limit equivalent to serum HCV RNA levels of approximately 100 IU/mL. It is highly sensitive and specific in the setting of HIV coinfection, regardless of HIV infection status and CD4 count. These data support the clinical application of the HCV-Ags EIA in one-step diagnosis of HCV infection in HIV-infected individuals. PMID: 31183004 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - June 13, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Expanding etiology of progressive familial intrahepatic cholestasis.
CONCLUSION: We present a summary of current advances made in a number of areas relevant to both the classically described FIC1 (ATP8B1), BSEP (ABCB11), and MDR3 (ABCB4) transporter deficiencies, as well as more recently described gene mutations -- TJP2 (TJP2), FXR (NR1H4), MYO5B (MYO5B), and others which expand the etiology and understanding of PFIC-related cholestatic diseases and bile transport. PMID: 31183005 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - June 13, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Carvedilol vs endoscopic variceal ligation for primary and secondary prevention of variceal bleeding: Systematic review and meta-analysis.
CONCLUSION: Carvedilol had similar efficacy to EVL in preventing the first variceal bleeding in cirrhosis patients with esophageal varices. It was superior to EVL alone for secondary prevention of variceal bleeding in regard to all-cause mortality reduction. PMID: 31183006 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - June 13, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Neonatal cholestasis and hepatosplenomegaly caused by congenital dyserythropoietic anemia type 1: A case report.
CONCLUSION: We report liver pathology findings of CDA1 with a novel genetic mutation for the first time in a newborn. PMID: 31183007 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - June 13, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Successful treatment of noncirrhotic portal hypertension with eculizumab in paroxysmal nocturnal hemoglobinuria: A case report.
CONCLUSION: Eculizumab improved intravascular hemolysis and reversed clinical manifestations of INCPH in a patient with paroxysmal nocturnal hemoglobinuria. PMID: 31183008 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - June 13, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Endoscopic ultrasound guided liver biopsy for parenchymal liver disease.
Authors: Shah AR, Al-Hanayneh M, Chowdhry M, Bilal M, Singh S Abstract Liver biopsy plays an essential role in the diagnosis, evaluation and management of a vast proportion of liver diseases. Conventionally, percutaneous and trans-jugular approaches have been used to obtain liver biopsies. Endoscopic ultrasound guided liver biopsy (EUS-LB) has emerged as a safe and effective alternate in the past two decades. EUS-LB carries a role in evaluation of both benign and malignant diseases of the liver. It can offer higher resolution imaging of the liver and can detect smaller lesions than computed tomography scan of the a...
Source: World Journal of Hepatology - May 24, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

MicroRNAs contribute to ATP-binding cassette transporter- and autophagy-mediated chemoresistance in hepatocellular carcinoma.
Authors: Espelt MV, Bacigalupo ML, Carabias P, Troncoso MF Abstract Hepatocellular carcinoma (HCC) has an elevated mortality rate, largely because of high recurrence and metastasis. Additionally, the main obstacle during treatment of HCC is that patients usually develop resistance to chemotherapy. Cancer drug resistance involves many different mechanisms, including alterations in drug metabolism and processing, impairment of the apoptotic machine, activation of cell survival signaling, decreased drug sensitivity and autophagy, among others. Nowadays, miRNAs are emerging as master regulators of normal physiology- an...
Source: World Journal of Hepatology - May 24, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Beneficial effects of losartan or telmisartan on the local hepatic renin-angiotensin system to counter obesity in an experimental model.
Authors: Graus-Nunes F, Santos FO, Marinho TS, Miranda CS, Barbosa-da-Silva S, Souza-Mello V Abstract BACKGROUND: Obesity has been associated with hepatic overexpression of the renin-angiotensin system (RAS). AIM: To evaluate the action of two angiotensin II (ANGII) receptor blockers (losartan or telmisartan) on the modulation of local hepatic RAS and the resulting metabolic effects in a diet-induced obesity murine model. METHODS: Twenty C57BL/6 mice were randomly divided into two nutritional groups for 10 wk: control group (C, n = 5, 10% of energy as fat) or high-fat group (HF, n = 15, 50% of energy as fat...
Source: World Journal of Hepatology - May 24, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Being accompanied to liver discharge clinic: An easy measure to identify potential liver transplant candidates among those previously considered ineligible.
CONCLUSION: Patients who attended the first post-discharge TCLC appointment had a trend for higher liver transplant eligibility at 1 year. Being accompanied by family or friends during the first TCLC visit correlated with higher liver transplant eligibility at 1 year (attendance by family or friends was not requested). Patient and family engagement in the immediate post-hospitalization period may predict future liver transplant eligibility for patients previously declined. PMID: 31114641 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 24, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Effectiveness of venous thromboembolism prophylaxis in patients with liver disease.
Authors: Yerke J, Bauer SR, Bass S, Torbic H, Militello M, Roach E, Hanouneh I, Welch S Abstract BACKGROUND: Patients with liver disease are concomitantly at increased risk of venous thromboembolism (VTE) and bleeding events due to changes in the balance of pro- and anti-hemostatic substances. As such, recommendations for the use of pharmacological VTE prophylaxis are lacking. Recent studies have found no difference in rates of VTE in those receiving and not receiving pharmacological VTE prophylaxis, though most studies have been small. Thus, our study sought to establish if pharmacological VTE prophylaxis is effec...
Source: World Journal of Hepatology - May 24, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Nonalcoholic fatty liver disease prevalence in an Italian cohort of patients with hidradenitis suppurativa: A multi-center retrospective analysis.
Authors: Damiani G, Leone S, Fajgenbaum K, Bragazzi NL, Pacifico A, Conic RR, Pigatto PD, Maiorana C, Poli P, Berti E, Pace MC, Malagoli P, Bettoli V, Fiore M Abstract BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) includes two distinct conditions, with different histologic features and prognosis: non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). Furthermore, NASH is the more aggressive necro-inflammatory form, which may accumulate fibrosis and result in End stage liver disease (ESLD). NAFLD is also linked to systemic inflammatory conditions such as psoriasis. NAFLD is currently the m...
Source: World Journal of Hepatology - May 24, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Leukocytoclastic vasculitis caused by hepatitis C virus in a liver transplant recipient: A case report.
CONCLUSION: This case highlights the difficulties of diagnosing skin lesions caused by HCV infection in immunosuppressed patients. PMID: 31114644 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 24, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Yes-associated protein at the intersection of liver cell fate determination.
Authors: Bai YF, Wang SW, Xu ZC, Zhu J, Zhang F Abstract A recent publication highlights the importance of high yes-associated protein (YAP) expressing cells in liver regeneration following partial hepatectomy. Although the names of the cell populations described in these articles [hybrid periportal hepatocytes (HybHP) or epithelial-mesenchymal transition (EMT)-reprogrammed hepatocytes] are not identical, they all express high levels of YAP. We hypothesize that the HybHP and EMT-reprogrammed hepatocytes might be a similar cell population. Hippo signaling is the primary pathway that regulates YAP activity. According...
Source: World Journal of Hepatology - May 24, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Update on management of gastric varices.
Authors: Vine LJ, Subhani M, Acevedo JG Abstract Gastric varices (GV) have different physiology and clinical characteristics compared to oesophageal varices (OV). There is little information about the management of GV. Most part of the recommendations is extrapolated from studies where the majority of participants had OV. Thus, most recommendations lack of strong evidence. This is a comprehensive review on all aspects of management of GV, i.e., primary, secondary prophylaxis and management of acute bleeding. The papers on which international societies' recommendations are based are scrutinised in this review and ar...
Source: World Journal of Hepatology - April 11, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Hepatocellular carcinoma recurrence after liver transplantation: Risk factors, screening and clinical presentation.
Authors: Filgueira NA Abstract Liver transplantation is the best treatment option for cirrhotic patients with early-stage hepatocellular carcinoma, but it faces the problem of scarcity of donors and the risk of tumor recurrence, which affects between 15% and 20% of the cases, despite the use of restrictive criteria. The risk of recurrence depends on a number of factors, related to the tumor, the patient, and the treatment, which are discussed in this review. Some of these factors are already well established, such as the histopathological characteristics of the tumor, Alpha-fetoprotein (AFP) levels, and waiting tim...
Source: World Journal of Hepatology - April 11, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Protective action of glutamine in rats with severe acute liver failure.
Authors: Schemitt EG, Hartmann RM, Colares JR, Licks F, Salvi JO, Marroni CA, Marroni NP Abstract BACKGROUND: Severe acute liver failure (SALF) is a rare, but high-mortality, rapidly evolving syndrome that leads to hepatocyte degeneration with impaired liver function. Thioacetamide (TAA) is a known xenobiotic, which promotes the increase of the formation of reactive oxygen species. Erythroid 2-related factor 2 (Nrf2) activates the antioxidant protection of cells. Studies have evidenced the involvement of inflammatory mediators in conditions of oxidative stress. AIM: To evaluate the antioxidant effects of glutam...
Source: World Journal of Hepatology - April 11, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Extreme hyperbilirubinemia: An indicator of morbidity and mortality in sickle cell disease.
Authors: Haydek JP, Taborda C, Shah R, Reshamwala PA, McLemore ML, Rassi FE, Chawla S Abstract BACKGROUND: Sickle cell disease (SCD) is a disorder that results in increased hospitalizations and higher mortality. Advances in management have resulted in increases in life expectancy and led to increasing awareness of sickle cell hepatopathy (SCH). However, its impact in patients on the natural history and outcomes of SCD is not known. Our study aims to describe the prevalence of extreme hyperbilirubinemia (EH), one form of SCH, its effect on morbidity and mortality, and correlations between sickle cell genotype and SC...
Source: World Journal of Hepatology - April 11, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Angiogenesis of hepatocellular carcinoma: An immunohistochemistry study.
CONCLUSION: In patients with HCC developed in cirrhosis, the newly formed vessels are rather immature and their genesis is mediated via VEGF. In patients with non-cirrhotic liver, COX-2 intensity and number of mature neoformed vessels increases in parallel with HCC dedifferentiation. PMID: 30967907 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 11, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Preoperative immunonutrition in patients undergoing liver resection: A prospective randomized trial.
Authors: Russell K, Zhang HG, Gillanders LK, Bartlett AS, Fisk HL, Calder PC, Swan PJ, Plank LD Abstract BACKGROUND: Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection. AIM: To evaluate the effects of preoperative nutritional supplementation enriched with arginine ...
Source: World Journal of Hepatology - April 11, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Intraperitoneal rupture of the hydatid cyst: Four case reports and literature review.
CONCLUSION: Intraperitoneal rupture is a life-threatening complication of hydatid cysts. It is important to manage patients with surgical intervention as soon as possible with aggressive medical treatment for anaphylactic reactions. PMID: 30967909 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 11, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Persistent elevation of fibrosis biomarker cartilage oligomeric matrix protein following hepatitis C virus eradication.
We present a prospective analysis of this biomarker in 38 patients with chronic hepatitis C who were subject to eradication therapy with direct acting antivirals. We confirm previous studies associating COMP elevation with liver cirrhosis. We also show how viral levels are correlated with COMP at baseline. In our prospective analysis, we report that successful eradication of hepatitis C results in improvement in liver stiffness and laboratory liver function tests at 1 year follow-up. In contrast, median COMP-levels remain unchanged during the study period. We conclude that the biomarker potential of COMP in the prospective...
Source: World Journal of Hepatology - April 11, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Bariatric surgery in patients with non-alcoholic fatty liver disease - from pathophysiology to clinical effects.
Authors: Laursen TL, Hagemann CA, Wei C, Kazankov K, Thomsen KL, Knop FK, Grønbæk H Abstract Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized as a significant liver disease, and it covers the disease spectrum from simple steatosis with a risk of development of non-alcoholic steatohepatitis (NASH) to fibrosis, subsequent cirrhosis, end-stage liver failure, and liver cancer with a potential need for liver transplantation. NAFLD and NASH are closely related to obesity, metabolic syndrome, and type 2 diabetes (T2D). The role of gut hormones, especially glucagon-like peptide 1 (GLP-1), i...
Source: World Journal of Hepatology - March 5, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Colorectal liver metastases: An update on multidisciplinary approach.
Authors: Chow FC, Chok KS Abstract Liver metastasis is the commonest form of distant metastasis in colorectal cancer. Selection criteria for surgery and liver-directed therapies have recently been extended. However, resectability remains poorly defined. Tumour biology is increasingly recognized as an important prognostic factor; hence molecular profiling has a growing role in risk stratification and management planning. Surgical resection is the only treatment modality for curative intent. The most appropriate surgical approach is yet to be established. The primary cancer and the hepatic metastasis can be removed s...
Source: World Journal of Hepatology - March 5, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Hepatic encephalopathy: Lessons from preclinical studies.
This article aimed to review the use of preclinical models to investigate HE. The most used animal species are rats and mice. Experimental models of type A HE include surgical procedures and the administration of hepatotoxic medications, whereas models of types B and C HE are generally surgically induced lesions in liver tissue, which evolve to hepatic cirrhosis. Preclinical models have allowed the comprehension of the pathways related to HE. PMID: 30820267 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 5, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Comprehensive analysis of HFE gene in hereditary hemochromatosis and in diseases associated with acquired iron overload.
CONCLUSION: A differential HFE association was observed for HH and for diseases associated with acquired IO (HCV, HCC). Since HFE is very distant from other histocompatibility loci, only weak associations were observed with these alleles. PMID: 30820268 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 5, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Clinical outcomes after major hepatectomy are acceptable in low-volume centers in the Caribbean.
CONCLUSION: There are unique geographic, political and financial limitations to healthcare delivery in the Caribbean. Nevertheless, clinical outcomes are acceptable in the established, low-volume hepatobiliary centers in the Eastern Caribbean. PMID: 30820269 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 5, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation.
CONCLUSION: There is substantial risk for CLABSI among children with BA listed for liver transplantation. No clinical, demographic, or laboratory factor we tested emerged as an independent predictor of CLABSI. While our data did not show an impact of CLABSI on the short-term clinical outcome, it would seem prudent to implement CLABSI reduction strategies in this population to the extent that each CLABSI event represents potentially preventable hospitalization, unnecessary healthcare dollar expenditures, and may exact an opportunity cost, in terms of missed allograft offers. PMID: 30820270 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 5, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Parallel transjugular intrahepatic portosystemic shunt with Viatorr ® stents for primary TIPS insufficiency: Case series and review of literature.
CONCLUSION: Viatorr® PS placement in the management of variceal hemorrhage is feasible with promising short term patency and clinical follow-up data. PMID: 30820271 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 5, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Necrolytic acral erythema in a human immunodeficiency virus/hepatitis C virus coinfected patient: A case report.
CONCLUSION: Clinicians should maintain high clinical suspicion for early recognition of NAE in patients with rash and HCV. PMID: 30820272 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 5, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research