Molecular pathways of liver regeneration: A comprehensive review
World J Hepatol. 2021 Mar 27;13(3):270-290. doi: 10.4254/wjh.v13.i3.270.ABSTRACTThe liver is a unique parenchymal organ with a regenerative capacity allowing it to restore up to 70% of its volume. Although knowledge of this phenomenon dates back to Greek mythology (the story of Prometheus), many aspects of liver regeneration are still not understood. A variety of different factors, including inflammatory cytokines, growth factors, and bile acids, promote liver regeneration and control the final size of the organ during typical regeneration, which is performed by mature hepatocytes, and during alternative regeneration, whic...
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Yana V Kiseleva Sevak Z Antonyan Tatyana S Zharikova Kirill A Tupikin Dmitry V Kalinin Yuri O Zharikov Source Type: research

Hepatitis D virus and liver transplantation: Indications and outcomes
World J Hepatol. 2021 Mar 27;13(3):291-299. doi: 10.4254/wjh.v13.i3.291.ABSTRACTHepatitis D virus (HDV) is a dependent virus that relies on hepatitis B virus for its replication and transmission. Chronic hepatitis D is a severe form of viral hepatitis that can result in end stage liver disease. Currently, pegylated interferon alpha is the only approved therapy for chronic HDV infection and is associated with significant side effects. Liver transplantation (LT) is the only treatment option for patients with end-stage liver disease, hepatocellular carcinoma, or fulminant hepatitis due to coinfection with HDV. As LT for HDV a...
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Haris Muhammad Aniqa Tehreem Muhammad Baraa Hammami Peng-Sheng Ting Ramzan Idilman Ahmet Gurakar Source Type: research

Lymphatic dysfunction in advanced cirrhosis: Contextual perspective and clinical implications
This article discusses the perspectives and clinical implications, and provides insights into the management strategies for lymphatic dysfunction in patients with cirrhosis.PMID:33815674 | PMC:PMC8006079 | DOI:10.4254/wjh.v13.i3.300 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Ramesh Kumar Utpal Anand Rajeev Nayan Priyadarshi Source Type: research

Papaya improves non-alcoholic fatty liver disease in obese rats by attenuating oxidative stress, inflammation and lipogenic gene expression
World J Hepatol. 2021 Mar 27;13(3):315-327. doi: 10.4254/wjh.v13.i3.315.ABSTRACTBACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a global health issue that is correlated with obesity and oxidative stress.AIM: To evaluate the anti-NAFLD effect of papaya in high fat diet induced obesity in rats.METHODS: Four-week-old male Sprague-Dawley rats were divided into four groups after 1 wk of acclimatization: Group 1 was the rats fed a normal diet (C); group 2 was the rats fed a high fat diet (HFD); group 3 was the rats fed a HFD with 0.5 mL of papaya juice/100 g body weight (HFL), and group 4 was the rats fed a HFD with 1 m...
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Wanwisa Deenin Wachirawadee Malakul Tantip Boonsong Ittipon Phoungpetchara Sakara Tunsophon Source Type: research

Promotive action of 2-acetylaminofluorene on hepatic precancerous lesions initiated by diethylnitrosamine in rats: Molecular study
CONCLUSION: 2-AFF promoted hepatic precancerous lesions initiated through DEN by decreasing autophagy, apoptosis, and tumor suppression genes, along with increased cell proliferation, in a time- and dose-dependent manner. These actions were mediated under the epigenetic regulation of lncRNA RP11-513I15.6/miR-1262/miR-1298.PMID:33815676 | PMC:PMC8006078 | DOI:10.4254/wjh.v13.i3.328 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Amany Helmy Hasanin Eman K Habib Nesreen El Gayar Marwa Matboli Source Type: research

BIR repeat-containing ubiquitin conjugating enzyme (BRUCE) regulation of β-catenin signaling in the progression of drug-induced hepatic fibrosis and carcinogenesis
CONCLUSION: Our data support a "BRUCE-PKA-β-catenin" signaling axis in the mouse liver. The BRUCE interaction with PKA in hepatocytes suppresses PKA-dependent phosphorylation and activation of β-catenin. This study implicates BRUCE as a novel negative regulator of both PKA and β-catenin in chronic liver disease progression. Furthermore, BRUCE-liver specific KO mice serve as a promising model for understanding hepatic fibrosis and HCC in patients with aberrant activation of PKA and β-catenin.PMID:33815677 | PMC:PMC8006081 | DOI:10.4254/wjh.v13.i3.343 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Chrystelle L Vilfranc Li-Xiao Che Krushna C Patra Liang Niu Olugbenga Olowokure Jiang Wang Shimul A Shah Chun-Ying Du Source Type: research

Early tacrolimus exposure does not impact long-term outcomes after liver transplantation
CONCLUSION: Differences in tacrolimus levels restricted to the first month after transplant did not result in significant differences in long-term outcomes of LT recipients.PMID:33815678 | PMC:PMC8006083 | DOI:10.4254/wjh.v13.i3.362 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Mikel Gastaca Patricia Ruiz Javier Bustamante Lorea Martinez-Indart Alberto Ventoso Jos é Ramón Fernandez Ibone Palomares Mikel Prieto Milagros Testillano Patricia Salvador Maria Senosiain Maria Jesus Su árez Andres Valdivieso Source Type: research

Efficacy and safety of once daily tacrolimus compared to twice daily tacrolimus after liver transplantation
CONCLUSION: The analysis findings confirm that both once daily and twice daily tacrolimus formulations are comparable in terms of efficacy and safety outcomes.PMID:33815679 | PMC:PMC8006077 | DOI:10.4254/wjh.v13.i3.375 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Khalid Ibrahim Bzeizi Ali Albenmousa Abdulhaleem Mohamed Shawkat Zidan Ahmed Saleh Alabbad Waleed Alhamoudi Roberto Troisi Deiter Broering Source Type: research

Conversion hepatectomy for hepatocellular carcinoma with main portal vein tumour thrombus after lenvatinib treatment: A case report
CONCLUSION: This is the first case of HCC with Vp4 PVTT in which radical conversion hepatectomy was succeeded after lenvatinib treatment.PMID:33815680 | PMC:PMC8006080 | DOI:10.4254/wjh.v13.i3.384 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Kazuhiro Takahashi Jaejeong Kim Amane Takahashi Shinji Hashimoto Manami Doi Kinji Furuya Ryosuke Hashimoto Yohei Owada Koichi Ogawa Yusuke Ohara Yoshimasa Akashi Katsuji Hisakura Tsuyoshi Enomoto Osamu Shimomura Masayuki Noguchi Tatsuya Oda Source Type: research

Molecular pathways of liver regeneration: A comprehensive review
World J Hepatol. 2021 Mar 27;13(3):270-290. doi: 10.4254/wjh.v13.i3.270.ABSTRACTThe liver is a unique parenchymal organ with a regenerative capacity allowing it to restore up to 70% of its volume. Although knowledge of this phenomenon dates back to Greek mythology (the story of Prometheus), many aspects of liver regeneration are still not understood. A variety of different factors, including inflammatory cytokines, growth factors, and bile acids, promote liver regeneration and control the final size of the organ during typical regeneration, which is performed by mature hepatocytes, and during alternative regeneration, whic...
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Yana V Kiseleva Sevak Z Antonyan Tatyana S Zharikova Kirill A Tupikin Dmitry V Kalinin Yuri O Zharikov Source Type: research

Hepatitis D virus and liver transplantation: Indications and outcomes
World J Hepatol. 2021 Mar 27;13(3):291-299. doi: 10.4254/wjh.v13.i3.291.ABSTRACTHepatitis D virus (HDV) is a dependent virus that relies on hepatitis B virus for its replication and transmission. Chronic hepatitis D is a severe form of viral hepatitis that can result in end stage liver disease. Currently, pegylated interferon alpha is the only approved therapy for chronic HDV infection and is associated with significant side effects. Liver transplantation (LT) is the only treatment option for patients with end-stage liver disease, hepatocellular carcinoma, or fulminant hepatitis due to coinfection with HDV. As LT for HDV a...
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Haris Muhammad Aniqa Tehreem Muhammad Baraa Hammami Peng-Sheng Ting Ramzan Idilman Ahmet Gurakar Source Type: research

Lymphatic dysfunction in advanced cirrhosis: Contextual perspective and clinical implications
This article discusses the perspectives and clinical implications, and provides insights into the management strategies for lymphatic dysfunction in patients with cirrhosis.PMID:33815674 | PMC:PMC8006079 | DOI:10.4254/wjh.v13.i3.300 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Ramesh Kumar Utpal Anand Rajeev Nayan Priyadarshi Source Type: research

Papaya improves non-alcoholic fatty liver disease in obese rats by attenuating oxidative stress, inflammation and lipogenic gene expression
World J Hepatol. 2021 Mar 27;13(3):315-327. doi: 10.4254/wjh.v13.i3.315.ABSTRACTBACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a global health issue that is correlated with obesity and oxidative stress.AIM: To evaluate the anti-NAFLD effect of papaya in high fat diet induced obesity in rats.METHODS: Four-week-old male Sprague-Dawley rats were divided into four groups after 1 wk of acclimatization: Group 1 was the rats fed a normal diet (C); group 2 was the rats fed a high fat diet (HFD); group 3 was the rats fed a HFD with 0.5 mL of papaya juice/100 g body weight (HFL), and group 4 was the rats fed a HFD with 1 m...
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Wanwisa Deenin Wachirawadee Malakul Tantip Boonsong Ittipon Phoungpetchara Sakara Tunsophon Source Type: research

Promotive action of 2-acetylaminofluorene on hepatic precancerous lesions initiated by diethylnitrosamine in rats: Molecular study
CONCLUSION: 2-AFF promoted hepatic precancerous lesions initiated through DEN by decreasing autophagy, apoptosis, and tumor suppression genes, along with increased cell proliferation, in a time- and dose-dependent manner. These actions were mediated under the epigenetic regulation of lncRNA RP11-513I15.6/miR-1262/miR-1298.PMID:33815676 | PMC:PMC8006078 | DOI:10.4254/wjh.v13.i3.328 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Amany Helmy Hasanin Eman K Habib Nesreen El Gayar Marwa Matboli Source Type: research

BIR repeat-containing ubiquitin conjugating enzyme (BRUCE) regulation of β-catenin signaling in the progression of drug-induced hepatic fibrosis and carcinogenesis
CONCLUSION: Our data support a "BRUCE-PKA-β-catenin" signaling axis in the mouse liver. The BRUCE interaction with PKA in hepatocytes suppresses PKA-dependent phosphorylation and activation of β-catenin. This study implicates BRUCE as a novel negative regulator of both PKA and β-catenin in chronic liver disease progression. Furthermore, BRUCE-liver specific KO mice serve as a promising model for understanding hepatic fibrosis and HCC in patients with aberrant activation of PKA and β-catenin.PMID:33815677 | PMC:PMC8006081 | DOI:10.4254/wjh.v13.i3.343 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Chrystelle L Vilfranc Li-Xiao Che Krushna C Patra Liang Niu Olugbenga Olowokure Jiang Wang Shimul A Shah Chun-Ying Du Source Type: research

Early tacrolimus exposure does not impact long-term outcomes after liver transplantation
CONCLUSION: Differences in tacrolimus levels restricted to the first month after transplant did not result in significant differences in long-term outcomes of LT recipients.PMID:33815678 | PMC:PMC8006083 | DOI:10.4254/wjh.v13.i3.362 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Mikel Gastaca Patricia Ruiz Javier Bustamante Lorea Martinez-Indart Alberto Ventoso Jos é Ramón Fernandez Ibone Palomares Mikel Prieto Milagros Testillano Patricia Salvador Maria Senosiain Maria Jesus Su árez Andres Valdivieso Source Type: research

Efficacy and safety of once daily tacrolimus compared to twice daily tacrolimus after liver transplantation
CONCLUSION: The analysis findings confirm that both once daily and twice daily tacrolimus formulations are comparable in terms of efficacy and safety outcomes.PMID:33815679 | PMC:PMC8006077 | DOI:10.4254/wjh.v13.i3.375 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Khalid Ibrahim Bzeizi Ali Albenmousa Abdulhaleem Mohamed Shawkat Zidan Ahmed Saleh Alabbad Waleed Alhamoudi Roberto Troisi Deiter Broering Source Type: research

Conversion hepatectomy for hepatocellular carcinoma with main portal vein tumour thrombus after lenvatinib treatment: A case report
CONCLUSION: This is the first case of HCC with Vp4 PVTT in which radical conversion hepatectomy was succeeded after lenvatinib treatment.PMID:33815680 | PMC:PMC8006080 | DOI:10.4254/wjh.v13.i3.384 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Kazuhiro Takahashi Jaejeong Kim Amane Takahashi Shinji Hashimoto Manami Doi Kinji Furuya Ryosuke Hashimoto Yohei Owada Koichi Ogawa Yusuke Ohara Yoshimasa Akashi Katsuji Hisakura Tsuyoshi Enomoto Osamu Shimomura Masayuki Noguchi Tatsuya Oda Source Type: research

Molecular pathways of liver regeneration: A comprehensive review
World J Hepatol. 2021 Mar 27;13(3):270-290. doi: 10.4254/wjh.v13.i3.270.ABSTRACTThe liver is a unique parenchymal organ with a regenerative capacity allowing it to restore up to 70% of its volume. Although knowledge of this phenomenon dates back to Greek mythology (the story of Prometheus), many aspects of liver regeneration are still not understood. A variety of different factors, including inflammatory cytokines, growth factors, and bile acids, promote liver regeneration and control the final size of the organ during typical regeneration, which is performed by mature hepatocytes, and during alternative regeneration, whic...
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Yana V Kiseleva Sevak Z Antonyan Tatyana S Zharikova Kirill A Tupikin Dmitry V Kalinin Yuri O Zharikov Source Type: research

Hepatitis D virus and liver transplantation: Indications and outcomes
World J Hepatol. 2021 Mar 27;13(3):291-299. doi: 10.4254/wjh.v13.i3.291.ABSTRACTHepatitis D virus (HDV) is a dependent virus that relies on hepatitis B virus for its replication and transmission. Chronic hepatitis D is a severe form of viral hepatitis that can result in end stage liver disease. Currently, pegylated interferon alpha is the only approved therapy for chronic HDV infection and is associated with significant side effects. Liver transplantation (LT) is the only treatment option for patients with end-stage liver disease, hepatocellular carcinoma, or fulminant hepatitis due to coinfection with HDV. As LT for HDV a...
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Haris Muhammad Aniqa Tehreem Muhammad Baraa Hammami Peng-Sheng Ting Ramzan Idilman Ahmet Gurakar Source Type: research

Lymphatic dysfunction in advanced cirrhosis: Contextual perspective and clinical implications
This article discusses the perspectives and clinical implications, and provides insights into the management strategies for lymphatic dysfunction in patients with cirrhosis.PMID:33815674 | PMC:PMC8006079 | DOI:10.4254/wjh.v13.i3.300 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Ramesh Kumar Utpal Anand Rajeev Nayan Priyadarshi Source Type: research

Papaya improves non-alcoholic fatty liver disease in obese rats by attenuating oxidative stress, inflammation and lipogenic gene expression
World J Hepatol. 2021 Mar 27;13(3):315-327. doi: 10.4254/wjh.v13.i3.315.ABSTRACTBACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a global health issue that is correlated with obesity and oxidative stress.AIM: To evaluate the anti-NAFLD effect of papaya in high fat diet induced obesity in rats.METHODS: Four-week-old male Sprague-Dawley rats were divided into four groups after 1 wk of acclimatization: Group 1 was the rats fed a normal diet (C); group 2 was the rats fed a high fat diet (HFD); group 3 was the rats fed a HFD with 0.5 mL of papaya juice/100 g body weight (HFL), and group 4 was the rats fed a HFD with 1 m...
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Wanwisa Deenin Wachirawadee Malakul Tantip Boonsong Ittipon Phoungpetchara Sakara Tunsophon Source Type: research

Promotive action of 2-acetylaminofluorene on hepatic precancerous lesions initiated by diethylnitrosamine in rats: Molecular study
CONCLUSION: 2-AFF promoted hepatic precancerous lesions initiated through DEN by decreasing autophagy, apoptosis, and tumor suppression genes, along with increased cell proliferation, in a time- and dose-dependent manner. These actions were mediated under the epigenetic regulation of lncRNA RP11-513I15.6/miR-1262/miR-1298.PMID:33815676 | PMC:PMC8006078 | DOI:10.4254/wjh.v13.i3.328 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Amany Helmy Hasanin Eman K Habib Nesreen El Gayar Marwa Matboli Source Type: research

BIR repeat-containing ubiquitin conjugating enzyme (BRUCE) regulation of β-catenin signaling in the progression of drug-induced hepatic fibrosis and carcinogenesis
CONCLUSION: Our data support a "BRUCE-PKA-β-catenin" signaling axis in the mouse liver. The BRUCE interaction with PKA in hepatocytes suppresses PKA-dependent phosphorylation and activation of β-catenin. This study implicates BRUCE as a novel negative regulator of both PKA and β-catenin in chronic liver disease progression. Furthermore, BRUCE-liver specific KO mice serve as a promising model for understanding hepatic fibrosis and HCC in patients with aberrant activation of PKA and β-catenin.PMID:33815677 | PMC:PMC8006081 | DOI:10.4254/wjh.v13.i3.343 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Chrystelle L Vilfranc Li-Xiao Che Krushna C Patra Liang Niu Olugbenga Olowokure Jiang Wang Shimul A Shah Chun-Ying Du Source Type: research

Early tacrolimus exposure does not impact long-term outcomes after liver transplantation
CONCLUSION: Differences in tacrolimus levels restricted to the first month after transplant did not result in significant differences in long-term outcomes of LT recipients.PMID:33815678 | PMC:PMC8006083 | DOI:10.4254/wjh.v13.i3.362 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Mikel Gastaca Patricia Ruiz Javier Bustamante Lorea Martinez-Indart Alberto Ventoso Jos é Ramón Fernandez Ibone Palomares Mikel Prieto Milagros Testillano Patricia Salvador Maria Senosiain Maria Jesus Su árez Andres Valdivieso Source Type: research

Efficacy and safety of once daily tacrolimus compared to twice daily tacrolimus after liver transplantation
CONCLUSION: The analysis findings confirm that both once daily and twice daily tacrolimus formulations are comparable in terms of efficacy and safety outcomes.PMID:33815679 | PMC:PMC8006077 | DOI:10.4254/wjh.v13.i3.375 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Khalid Ibrahim Bzeizi Ali Albenmousa Abdulhaleem Mohamed Shawkat Zidan Ahmed Saleh Alabbad Waleed Alhamoudi Roberto Troisi Deiter Broering Source Type: research

Conversion hepatectomy for hepatocellular carcinoma with main portal vein tumour thrombus after lenvatinib treatment: A case report
CONCLUSION: This is the first case of HCC with Vp4 PVTT in which radical conversion hepatectomy was succeeded after lenvatinib treatment.PMID:33815680 | PMC:PMC8006080 | DOI:10.4254/wjh.v13.i3.384 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Kazuhiro Takahashi Jaejeong Kim Amane Takahashi Shinji Hashimoto Manami Doi Kinji Furuya Ryosuke Hashimoto Yohei Owada Koichi Ogawa Yusuke Ohara Yoshimasa Akashi Katsuji Hisakura Tsuyoshi Enomoto Osamu Shimomura Masayuki Noguchi Tatsuya Oda Source Type: research

Molecular pathways of liver regeneration: A comprehensive review
World J Hepatol. 2021 Mar 27;13(3):270-290. doi: 10.4254/wjh.v13.i3.270.ABSTRACTThe liver is a unique parenchymal organ with a regenerative capacity allowing it to restore up to 70% of its volume. Although knowledge of this phenomenon dates back to Greek mythology (the story of Prometheus), many aspects of liver regeneration are still not understood. A variety of different factors, including inflammatory cytokines, growth factors, and bile acids, promote liver regeneration and control the final size of the organ during typical regeneration, which is performed by mature hepatocytes, and during alternative regeneration, whic...
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Yana V Kiseleva Sevak Z Antonyan Tatyana S Zharikova Kirill A Tupikin Dmitry V Kalinin Yuri O Zharikov Source Type: research

Hepatitis D virus and liver transplantation: Indications and outcomes
World J Hepatol. 2021 Mar 27;13(3):291-299. doi: 10.4254/wjh.v13.i3.291.ABSTRACTHepatitis D virus (HDV) is a dependent virus that relies on hepatitis B virus for its replication and transmission. Chronic hepatitis D is a severe form of viral hepatitis that can result in end stage liver disease. Currently, pegylated interferon alpha is the only approved therapy for chronic HDV infection and is associated with significant side effects. Liver transplantation (LT) is the only treatment option for patients with end-stage liver disease, hepatocellular carcinoma, or fulminant hepatitis due to coinfection with HDV. As LT for HDV a...
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Haris Muhammad Aniqa Tehreem Muhammad Baraa Hammami Peng-Sheng Ting Ramzan Idilman Ahmet Gurakar Source Type: research

Lymphatic dysfunction in advanced cirrhosis: Contextual perspective and clinical implications
This article discusses the perspectives and clinical implications, and provides insights into the management strategies for lymphatic dysfunction in patients with cirrhosis.PMID:33815674 | PMC:PMC8006079 | DOI:10.4254/wjh.v13.i3.300 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Ramesh Kumar Utpal Anand Rajeev Nayan Priyadarshi Source Type: research

Papaya improves non-alcoholic fatty liver disease in obese rats by attenuating oxidative stress, inflammation and lipogenic gene expression
World J Hepatol. 2021 Mar 27;13(3):315-327. doi: 10.4254/wjh.v13.i3.315.ABSTRACTBACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a global health issue that is correlated with obesity and oxidative stress.AIM: To evaluate the anti-NAFLD effect of papaya in high fat diet induced obesity in rats.METHODS: Four-week-old male Sprague-Dawley rats were divided into four groups after 1 wk of acclimatization: Group 1 was the rats fed a normal diet (C); group 2 was the rats fed a high fat diet (HFD); group 3 was the rats fed a HFD with 0.5 mL of papaya juice/100 g body weight (HFL), and group 4 was the rats fed a HFD with 1 m...
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Wanwisa Deenin Wachirawadee Malakul Tantip Boonsong Ittipon Phoungpetchara Sakara Tunsophon Source Type: research

Promotive action of 2-acetylaminofluorene on hepatic precancerous lesions initiated by diethylnitrosamine in rats: Molecular study
CONCLUSION: 2-AFF promoted hepatic precancerous lesions initiated through DEN by decreasing autophagy, apoptosis, and tumor suppression genes, along with increased cell proliferation, in a time- and dose-dependent manner. These actions were mediated under the epigenetic regulation of lncRNA RP11-513I15.6/miR-1262/miR-1298.PMID:33815676 | PMC:PMC8006078 | DOI:10.4254/wjh.v13.i3.328 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Amany Helmy Hasanin Eman K Habib Nesreen El Gayar Marwa Matboli Source Type: research

BIR repeat-containing ubiquitin conjugating enzyme (BRUCE) regulation of β-catenin signaling in the progression of drug-induced hepatic fibrosis and carcinogenesis
CONCLUSION: Our data support a "BRUCE-PKA-β-catenin" signaling axis in the mouse liver. The BRUCE interaction with PKA in hepatocytes suppresses PKA-dependent phosphorylation and activation of β-catenin. This study implicates BRUCE as a novel negative regulator of both PKA and β-catenin in chronic liver disease progression. Furthermore, BRUCE-liver specific KO mice serve as a promising model for understanding hepatic fibrosis and HCC in patients with aberrant activation of PKA and β-catenin.PMID:33815677 | PMC:PMC8006081 | DOI:10.4254/wjh.v13.i3.343 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Chrystelle L Vilfranc Li-Xiao Che Krushna C Patra Liang Niu Olugbenga Olowokure Jiang Wang Shimul A Shah Chun-Ying Du Source Type: research

Early tacrolimus exposure does not impact long-term outcomes after liver transplantation
CONCLUSION: Differences in tacrolimus levels restricted to the first month after transplant did not result in significant differences in long-term outcomes of LT recipients.PMID:33815678 | PMC:PMC8006083 | DOI:10.4254/wjh.v13.i3.362 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Mikel Gastaca Patricia Ruiz Javier Bustamante Lorea Martinez-Indart Alberto Ventoso Jos é Ramón Fernandez Ibone Palomares Mikel Prieto Milagros Testillano Patricia Salvador Maria Senosiain Maria Jesus Su árez Andres Valdivieso Source Type: research

Efficacy and safety of once daily tacrolimus compared to twice daily tacrolimus after liver transplantation
CONCLUSION: The analysis findings confirm that both once daily and twice daily tacrolimus formulations are comparable in terms of efficacy and safety outcomes.PMID:33815679 | PMC:PMC8006077 | DOI:10.4254/wjh.v13.i3.375 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Khalid Ibrahim Bzeizi Ali Albenmousa Abdulhaleem Mohamed Shawkat Zidan Ahmed Saleh Alabbad Waleed Alhamoudi Roberto Troisi Deiter Broering Source Type: research

Conversion hepatectomy for hepatocellular carcinoma with main portal vein tumour thrombus after lenvatinib treatment: A case report
CONCLUSION: This is the first case of HCC with Vp4 PVTT in which radical conversion hepatectomy was succeeded after lenvatinib treatment.PMID:33815680 | PMC:PMC8006080 | DOI:10.4254/wjh.v13.i3.384 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 5, 2021 Category: Gastroenterology Authors: Kazuhiro Takahashi Jaejeong Kim Amane Takahashi Shinji Hashimoto Manami Doi Kinji Furuya Ryosuke Hashimoto Yohei Owada Koichi Ogawa Yusuke Ohara Yoshimasa Akashi Katsuji Hisakura Tsuyoshi Enomoto Osamu Shimomura Masayuki Noguchi Tatsuya Oda Source Type: research

Meeting report of the editorial board meeting for < em > World Journal of Hepatology < /em > 2021
World J Hepatol. 2021 Feb 27;13(2):162-165. doi: 10.4254/wjh.v13.i2.162.ABSTRACTThe 2021 online editorial board meeting of the World Journal of Hepatology (WJH) was held on January 16, 2021. Xiang Li, Director of Production Office on behalf of the Baishideng Publishing Group, organized the meeting. Three Editors-in-Chiefs (EiCs) and 15 Baishideng Publishing Group staff attended the meeting. The meeting goal was to brief EiCs on journal performance and gather ideas for journal development in 2021. In 2020, WJH published 204 articles, a 20% increase compared to 2019, authors were from 32 countries and regions, and the averag...
Source: World Journal of Hepatology - March 12, 2021 Category: Gastroenterology Authors: Li Ma Xiang Li Source Type: research

Extrahepatic cholangiocarcinoma: Current status of endoscopic approach and additional therapies
World J Hepatol. 2021 Feb 27;13(2):166-186. doi: 10.4254/wjh.v13.i2.166.ABSTRACTThe prognosis of patients with advanced or unresectable extrahepatic cholangiocarcinoma is poor. More than 50% of patients with jaundice are inoperable at the time of first diagnosis. Endoscopic treatment in patients with obstructive jaundice ensures bile duct drainage in preoperative or palliative settings. Relief of symptoms (pain, pruritus, jaundice) and improvement in quality of life are the aims of palliative therapy. Stent implantation by endoscopic retrograde cholangiopancreatography is generally preferred for long-term palliation. There...
Source: World Journal of Hepatology - March 12, 2021 Category: Gastroenterology Authors: Alina Ioana Tantau Alina Mandrutiu Anamaria Pop Roxana Delia Zaharie Dana Crisan Carmen Monica Preda Marcel Tantau Voicu Mercea Source Type: research

Adult human liver slice cultures: Modelling of liver fibrosis and evaluation of new anti-fibrotic drugs
CONCLUSION: These results show that the human three dimensional ex vivo model effectively reflects the in vivo processes in damaged human liver (viral, alcoholic, nonalcoholic steatohepatitis liver diseases) and provides the proof of concept that the LS examined model permits a rapid evaluation of new anti-fibrotic therapies when used alone or in combination.PMID:33708350 | PMC:PMC7934011 | DOI:10.4254/wjh.v13.i2.187 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 12, 2021 Category: Gastroenterology Authors: Daria Kartasheva-Ebertz Jesintha Gaston Loriane Lair-Mehiri Pierre-Philippe Massault Olivier Scatton Jean-Christophe Vaillant Vladimir Alexei Morozov Stanislas Pol Sylvie Lagaye Source Type: research

Production and activity of matrix metalloproteinases during liver fibrosis progression of chronic hepatitis C patients
World J Hepatol. 2021 Feb 27;13(2):218-232. doi: 10.4254/wjh.v13.i2.218.ABSTRACTBACKGROUND: Matrix metalloproteinases (MMPs) participate in the degradation of extracellular matrix compounds, maintaining the homeostasis between fibrogenesis and fibrolytic processes in the liver. However, there are few studies on the regulation of liver MMPs in fibrosis progression in humans.AIM: To assess the production activity and regulation of matrix metalloproteinases in liver fibrosis stages in chronic hepatitis C (CHC).METHODS: A prospective, cross-sectional, multicenter study was conducted. CHC patients were categorized in fibrosis g...
Source: World Journal of Hepatology - March 12, 2021 Category: Gastroenterology Authors: Moises Martinez-Castillo Abigail Hernandez-Barragan Ivonne Flores-Vasconcelos Marina Galicia-Moreno Dorothy Rosique-Oramas Jose Luis Perez-Hernandez Fatima Higuera-De la Tijera Eduardo E Montalvo-Jave Aldo Torre-Delgadillo Paula Cordero-Perez Linda Mu ño Source Type: research

Awareness of non-alcoholic steatohepatitis and treatment guidelines: What are physicians telling us?
CONCLUSION: Substantial gaps in knowledge of the differences between NAFLD and NASH exist between these physician groups, with knowledge being particularly low among primary care doctors and endocrinologists. The use of a simple non-invasive screening algorithm may help to identify the right patients for clinical trials, which in turn will be vital to the development of effective and well-tolerated treatments for this increasingly ubiquitous condition.PMID:33708352 | PMC:PMC7934010 | DOI:10.4254/wjh.v13.i2.233 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 12, 2021 Category: Gastroenterology Authors: David Hermanus Wessels Zeil Rosenberg Source Type: research

Occult hepatitis C virus infection in the Middle East and Eastern Mediterranean countries: A systematic review and meta-analysis
World J Hepatol. 2021 Feb 27;13(2):242-260. doi: 10.4254/wjh.v13.i2.242.ABSTRACTBACKGROUND: The presence of hepatitis C virus (HCV) RNA in liver tissue or peripheral blood mononuclear cells with no identified virus genome in the serum has been reported worldwide among patients with either normal or elevated serum liver enzymes. The characterization of occult HCV infection (OCI) epidemiology in the Middle East and Eastern Mediterranean (M and E) countries, a region with the highest incidence and prevalence rates of HCV infection in the world, would be effective for more appropriate control of the infection.AIM: To estimate ...
Source: World Journal of Hepatology - March 12, 2021 Category: Gastroenterology Authors: Mohammad Reza Hedayati-Moghaddam Hossein Soltanian Sanaz Ahmadi-Ghezeldasht Source Type: research

Two-stage hepatectomy with radioembolization for bilateral colorectal liver metastases: A case report
CONCLUSION: According to this specific experience, TARE was used to induce liver hypertrophy and simultaneously control cancer progression in TSH settings for bilateral CRLM.PMID:33708354 | PMC:PMC7934009 | DOI:10.4254/wjh.v13.i2.261 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 12, 2021 Category: Gastroenterology Authors: Matteo Serenari Jacopo Neri Giovanni Marasco Cristina Larotonda Alberta Cappelli Matteo Ravaioli Cristina Mosconi Rita Golfieri Matteo Cescon Source Type: research

Meeting report of the editorial board meeting for < em > World Journal of Hepatology < /em > 2021
World J Hepatol. 2021 Feb 27;13(2):162-165. doi: 10.4254/wjh.v13.i2.162.ABSTRACTThe 2021 online editorial board meeting of the World Journal of Hepatology (WJH) was held on January 16, 2021. Xiang Li, Director of Production Office on behalf of the Baishideng Publishing Group, organized the meeting. Three Editors-in-Chiefs (EiCs) and 15 Baishideng Publishing Group staff attended the meeting. The meeting goal was to brief EiCs on journal performance and gather ideas for journal development in 2021. In 2020, WJH published 204 articles, a 20% increase compared to 2019, authors were from 32 countries and regions, and the averag...
Source: World Journal of Hepatology - March 12, 2021 Category: Gastroenterology Authors: Li Ma Xiang Li Source Type: research

Extrahepatic cholangiocarcinoma: Current status of endoscopic approach and additional therapies
World J Hepatol. 2021 Feb 27;13(2):166-186. doi: 10.4254/wjh.v13.i2.166.ABSTRACTThe prognosis of patients with advanced or unresectable extrahepatic cholangiocarcinoma is poor. More than 50% of patients with jaundice are inoperable at the time of first diagnosis. Endoscopic treatment in patients with obstructive jaundice ensures bile duct drainage in preoperative or palliative settings. Relief of symptoms (pain, pruritus, jaundice) and improvement in quality of life are the aims of palliative therapy. Stent implantation by endoscopic retrograde cholangiopancreatography is generally preferred for long-term palliation. There...
Source: World Journal of Hepatology - March 12, 2021 Category: Gastroenterology Authors: Alina Ioana Tantau Alina Mandrutiu Anamaria Pop Roxana Delia Zaharie Dana Crisan Carmen Monica Preda Marcel Tantau Voicu Mercea Source Type: research

Adult human liver slice cultures: Modelling of liver fibrosis and evaluation of new anti-fibrotic drugs
CONCLUSION: These results show that the human three dimensional ex vivo model effectively reflects the in vivo processes in damaged human liver (viral, alcoholic, nonalcoholic steatohepatitis liver diseases) and provides the proof of concept that the LS examined model permits a rapid evaluation of new anti-fibrotic therapies when used alone or in combination.PMID:33708350 | PMC:PMC7934011 | DOI:10.4254/wjh.v13.i2.187 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 12, 2021 Category: Gastroenterology Authors: Daria Kartasheva-Ebertz Jesintha Gaston Loriane Lair-Mehiri Pierre-Philippe Massault Olivier Scatton Jean-Christophe Vaillant Vladimir Alexei Morozov Stanislas Pol Sylvie Lagaye Source Type: research

Production and activity of matrix metalloproteinases during liver fibrosis progression of chronic hepatitis C patients
World J Hepatol. 2021 Feb 27;13(2):218-232. doi: 10.4254/wjh.v13.i2.218.ABSTRACTBACKGROUND: Matrix metalloproteinases (MMPs) participate in the degradation of extracellular matrix compounds, maintaining the homeostasis between fibrogenesis and fibrolytic processes in the liver. However, there are few studies on the regulation of liver MMPs in fibrosis progression in humans.AIM: To assess the production activity and regulation of matrix metalloproteinases in liver fibrosis stages in chronic hepatitis C (CHC).METHODS: A prospective, cross-sectional, multicenter study was conducted. CHC patients were categorized in fibrosis g...
Source: World Journal of Hepatology - March 12, 2021 Category: Gastroenterology Authors: Moises Martinez-Castillo Abigail Hernandez-Barragan Ivonne Flores-Vasconcelos Marina Galicia-Moreno Dorothy Rosique-Oramas Jose Luis Perez-Hernandez Fatima Higuera-De la Tijera Eduardo E Montalvo-Jave Aldo Torre-Delgadillo Paula Cordero-Perez Linda Mu ño Source Type: research

Awareness of non-alcoholic steatohepatitis and treatment guidelines: What are physicians telling us?
CONCLUSION: Substantial gaps in knowledge of the differences between NAFLD and NASH exist between these physician groups, with knowledge being particularly low among primary care doctors and endocrinologists. The use of a simple non-invasive screening algorithm may help to identify the right patients for clinical trials, which in turn will be vital to the development of effective and well-tolerated treatments for this increasingly ubiquitous condition.PMID:33708352 | PMC:PMC7934010 | DOI:10.4254/wjh.v13.i2.233 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 12, 2021 Category: Gastroenterology Authors: David Hermanus Wessels Zeil Rosenberg Source Type: research

Occult hepatitis C virus infection in the Middle East and Eastern Mediterranean countries: A systematic review and meta-analysis
World J Hepatol. 2021 Feb 27;13(2):242-260. doi: 10.4254/wjh.v13.i2.242.ABSTRACTBACKGROUND: The presence of hepatitis C virus (HCV) RNA in liver tissue or peripheral blood mononuclear cells with no identified virus genome in the serum has been reported worldwide among patients with either normal or elevated serum liver enzymes. The characterization of occult HCV infection (OCI) epidemiology in the Middle East and Eastern Mediterranean (M and E) countries, a region with the highest incidence and prevalence rates of HCV infection in the world, would be effective for more appropriate control of the infection.AIM: To estimate ...
Source: World Journal of Hepatology - March 12, 2021 Category: Gastroenterology Authors: Mohammad Reza Hedayati-Moghaddam Hossein Soltanian Sanaz Ahmadi-Ghezeldasht Source Type: research

Two-stage hepatectomy with radioembolization for bilateral colorectal liver metastases: A case report
CONCLUSION: According to this specific experience, TARE was used to induce liver hypertrophy and simultaneously control cancer progression in TSH settings for bilateral CRLM.PMID:33708354 | PMC:PMC7934009 | DOI:10.4254/wjh.v13.i2.261 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 12, 2021 Category: Gastroenterology Authors: Matteo Serenari Jacopo Neri Giovanni Marasco Cristina Larotonda Alberta Cappelli Matteo Ravaioli Cristina Mosconi Rita Golfieri Matteo Cescon Source Type: research