Pathologic and molecular features of hepatocellular carcinoma: An update
World J Hepatol. 2021 Apr 27;13(4):393-410. doi: 10.4254/wjh.v13.i4.393.ABSTRACTMorphological diversity and several new distinct pathologic subtypes of hepatocellular carcinoma (HCC) are now well-recognized. Recent advances in tumor genomics and transcriptomics have identified several recurrent somatic/genetic alterations that are closely related with histomorphological subtypes and have therefore, greatly improved our understanding of HCC pathogenesis. Pathologic subtyping allows for a diagnosis which is clinically helpful and can have important implication in patient prognostication as some of these subtypes are extremel...
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Mukul Vij Julien Calderaro Source Type: research

Infantile giant cell hepatitis with autoimmune hemolytic anemia
World J Hepatol. 2021 Apr 27;13(4):411-420. doi: 10.4254/wjh.v13.i4.411.ABSTRACTGiant cell hepatitis (GCH) is characterized by large and multinucleated (syncytial) hepatocytes in the context of liver inflammation. Infantile GCH is typically associated with autoimmune hemolytic anemia in the absence of any other systemic or organ-specific autoimmune comorbidity. The etiology is unknown; concomitant viral infections (as potential trigger factors) have been identified in a few patients. The pathogenesis reportedly relies upon immune-mediated/ autoimmune mechanisms. This condition should be considered in any infant developing ...
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Dimitri Poddighe Aidana Madiyeva Diana Talipova Balzhan Umirbekova Source Type: research

Long-term albumin infusion in decompensated cirrhosis: A review of current literature
World J Hepatol. 2021 Apr 27;13(4):421-432. doi: 10.4254/wjh.v13.i4.421.ABSTRACTDecompensated cirrhosis is characterized by chronic inflammation and severe portal hypertension leading to systemic circulatory dysfunction. Albumin infusion has been widely used in decompensated cirrhosis in patients with spontaneous bacterial peritonitis, large-volume paracentesis and hepatorenal syndrome. Emerging data suggest long-term albumin infusion has both oncotic and non-oncotic properties which may improve the clinical outcomes in decompensated cirrhosis patients. We review the current literature on both the established and potential...
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Yu Jun Wong Rahul Kumar Yu Jing Jonathan Chua Tiing Leong Ang Source Type: research

Bile acid indices as biomarkers for liver diseases I: Diagnostic markers
CONCLUSION: BA indices have much lower inter- and intra-individual variability compared to absolute BA concentrations and changes of BA indices are associated with the risk of developing liver diseases.PMID:33959226 | PMC:PMC8080550 | DOI:10.4254/wjh.v13.i4.433 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Jawaher Abdullah Alamoudi Wenkuan Li Nagsen Gautam Marco Olivera Jane Meza Sandeep Mukherjee Yazen Alnouti Source Type: research

Elderly patients ( ≥ 80 years) with acute calculous cholangitis have similar outcomes as non-elderly patients ( & lt; 80 years): Propensity score-matched analysis
CONCLUSION: Mortality is indifferent in the elderly (≥ 80 years old) and non-elderly patients (
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Kai Siang Chan Ramkumar Mohan Jee Keem Low Sameer P Junnarkar Cheong Wei Terence Huey Vishal G Shelat Source Type: research

Retrospective analysis of complications related to endoscopic retrograde cholangio-pancreatography in patients with cirrhosis < em > vs < /em > patients without cirrhosis
CONCLUSION: The results of our study reaffirm that liver cirrhosis has an impact on the occurrence of complications during ERCP. Our study shows that CP class seems to be more reliable as compared to MELD score in predicting complications of ERCP in cirrhosis patients.PMID:33959228 | PMC:PMC8080553 | DOI:10.4254/wjh.v13.i4.472 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Michelle Bernshteyn Linda Hu Umair Masood Anuj Vikrant Sharma Danning Huang Bishnu Sapkota Source Type: research

Fatal arterial hemorrhage after pancreaticoduodenectomy: How do we simultaneously accomplish complete hemostasis and hepatic arterial flow?
CONCLUSION: Transcatheter placement of a covered stent may be useful for simultaneous accomplishment of complete hemostasis and HA flow preservation.PMID:33959229 | PMC:PMC8080554 | DOI:10.4254/wjh.v13.i4.483 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Yasuyuki Kamada Tomohide Hori Hidekazu Yamamoto Hideki Harada Michihiro Yamamoto Masahiro Yamada Takefumi Yazawa Ben Sasaki Masaki Tani Asahi Sato Hikotaro Katsura Ryotaro Tani Ryuhei Aoyama Yudai Sasaki Masaharu Okada Masazumi Zaima Source Type: research

Dried blood spot sampling as an alternative for the improvement of hepatitis B and C diagnosis in key populations
CONCLUSION: DBS with electrochemiluminescence are useful tools for the diagnosis and prevalence studies of hepatitis B and C among key populations and may increase the opportunity to foster prevention and treatment.PMID:33959230 | PMC:PMC8080549 | DOI:10.4254/wjh.v13.i4.504 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Geane Lopes Flores Jakeline Ribeiro Barbosa Helena Medina Cruz Juliana Cust ódio Miguel Denise Vigo Potsch Jos é Henrique Pilotto Danielle Malta Lima Jeov á Keny Baima Colares Carlos Eduardo Brand ão-Mello Marcia Maria Amendola Pires Jurema Corr êa d Source Type: research

Asymptomatic portal vein aneurysm: Three case reports
CONCLUSION: As PVA remains asymptomatic in many cases, recognition of its imaging features is key to favourable outcomes.PMID:33959231 | PMC:PMC8080547 | DOI:10.4254/wjh.v13.i4.515 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Kateryna Priadko Marco Romano Luigi Maria Vitale Marco Niosi Ilario De Sio Source Type: research

Pathologic and molecular features of hepatocellular carcinoma: An update
World J Hepatol. 2021 Apr 27;13(4):393-410. doi: 10.4254/wjh.v13.i4.393.ABSTRACTMorphological diversity and several new distinct pathologic subtypes of hepatocellular carcinoma (HCC) are now well-recognized. Recent advances in tumor genomics and transcriptomics have identified several recurrent somatic/genetic alterations that are closely related with histomorphological subtypes and have therefore, greatly improved our understanding of HCC pathogenesis. Pathologic subtyping allows for a diagnosis which is clinically helpful and can have important implication in patient prognostication as some of these subtypes are extremel...
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Mukul Vij Julien Calderaro Source Type: research

Infantile giant cell hepatitis with autoimmune hemolytic anemia
World J Hepatol. 2021 Apr 27;13(4):411-420. doi: 10.4254/wjh.v13.i4.411.ABSTRACTGiant cell hepatitis (GCH) is characterized by large and multinucleated (syncytial) hepatocytes in the context of liver inflammation. Infantile GCH is typically associated with autoimmune hemolytic anemia in the absence of any other systemic or organ-specific autoimmune comorbidity. The etiology is unknown; concomitant viral infections (as potential trigger factors) have been identified in a few patients. The pathogenesis reportedly relies upon immune-mediated/ autoimmune mechanisms. This condition should be considered in any infant developing ...
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Dimitri Poddighe Aidana Madiyeva Diana Talipova Balzhan Umirbekova Source Type: research

Long-term albumin infusion in decompensated cirrhosis: A review of current literature
World J Hepatol. 2021 Apr 27;13(4):421-432. doi: 10.4254/wjh.v13.i4.421.ABSTRACTDecompensated cirrhosis is characterized by chronic inflammation and severe portal hypertension leading to systemic circulatory dysfunction. Albumin infusion has been widely used in decompensated cirrhosis in patients with spontaneous bacterial peritonitis, large-volume paracentesis and hepatorenal syndrome. Emerging data suggest long-term albumin infusion has both oncotic and non-oncotic properties which may improve the clinical outcomes in decompensated cirrhosis patients. We review the current literature on both the established and potential...
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Yu Jun Wong Rahul Kumar Yu Jing Jonathan Chua Tiing Leong Ang Source Type: research

Bile acid indices as biomarkers for liver diseases I: Diagnostic markers
CONCLUSION: BA indices have much lower inter- and intra-individual variability compared to absolute BA concentrations and changes of BA indices are associated with the risk of developing liver diseases.PMID:33959226 | PMC:PMC8080550 | DOI:10.4254/wjh.v13.i4.433 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Jawaher Abdullah Alamoudi Wenkuan Li Nagsen Gautam Marco Olivera Jane Meza Sandeep Mukherjee Yazen Alnouti Source Type: research

Elderly patients ( ≥ 80 years) with acute calculous cholangitis have similar outcomes as non-elderly patients ( & lt; 80 years): Propensity score-matched analysis
CONCLUSION: Mortality is indifferent in the elderly (≥ 80 years old) and non-elderly patients (
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Kai Siang Chan Ramkumar Mohan Jee Keem Low Sameer P Junnarkar Cheong Wei Terence Huey Vishal G Shelat Source Type: research

Retrospective analysis of complications related to endoscopic retrograde cholangio-pancreatography in patients with cirrhosis < em > vs < /em > patients without cirrhosis
CONCLUSION: The results of our study reaffirm that liver cirrhosis has an impact on the occurrence of complications during ERCP. Our study shows that CP class seems to be more reliable as compared to MELD score in predicting complications of ERCP in cirrhosis patients.PMID:33959228 | PMC:PMC8080553 | DOI:10.4254/wjh.v13.i4.472 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Michelle Bernshteyn Linda Hu Umair Masood Anuj Vikrant Sharma Danning Huang Bishnu Sapkota Source Type: research

Fatal arterial hemorrhage after pancreaticoduodenectomy: How do we simultaneously accomplish complete hemostasis and hepatic arterial flow?
CONCLUSION: Transcatheter placement of a covered stent may be useful for simultaneous accomplishment of complete hemostasis and HA flow preservation.PMID:33959229 | PMC:PMC8080554 | DOI:10.4254/wjh.v13.i4.483 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Yasuyuki Kamada Tomohide Hori Hidekazu Yamamoto Hideki Harada Michihiro Yamamoto Masahiro Yamada Takefumi Yazawa Ben Sasaki Masaki Tani Asahi Sato Hikotaro Katsura Ryotaro Tani Ryuhei Aoyama Yudai Sasaki Masaharu Okada Masazumi Zaima Source Type: research

Dried blood spot sampling as an alternative for the improvement of hepatitis B and C diagnosis in key populations
CONCLUSION: DBS with electrochemiluminescence are useful tools for the diagnosis and prevalence studies of hepatitis B and C among key populations and may increase the opportunity to foster prevention and treatment.PMID:33959230 | PMC:PMC8080549 | DOI:10.4254/wjh.v13.i4.504 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Geane Lopes Flores Jakeline Ribeiro Barbosa Helena Medina Cruz Juliana Cust ódio Miguel Denise Vigo Potsch Jos é Henrique Pilotto Danielle Malta Lima Jeov á Keny Baima Colares Carlos Eduardo Brand ão-Mello Marcia Maria Amendola Pires Jurema Corr êa d Source Type: research

Asymptomatic portal vein aneurysm: Three case reports
CONCLUSION: As PVA remains asymptomatic in many cases, recognition of its imaging features is key to favourable outcomes.PMID:33959231 | PMC:PMC8080547 | DOI:10.4254/wjh.v13.i4.515 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Kateryna Priadko Marco Romano Luigi Maria Vitale Marco Niosi Ilario De Sio Source Type: research

Pathologic and molecular features of hepatocellular carcinoma: An update
World J Hepatol. 2021 Apr 27;13(4):393-410. doi: 10.4254/wjh.v13.i4.393.ABSTRACTMorphological diversity and several new distinct pathologic subtypes of hepatocellular carcinoma (HCC) are now well-recognized. Recent advances in tumor genomics and transcriptomics have identified several recurrent somatic/genetic alterations that are closely related with histomorphological subtypes and have therefore, greatly improved our understanding of HCC pathogenesis. Pathologic subtyping allows for a diagnosis which is clinically helpful and can have important implication in patient prognostication as some of these subtypes are extremel...
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Mukul Vij Julien Calderaro Source Type: research

Infantile giant cell hepatitis with autoimmune hemolytic anemia
World J Hepatol. 2021 Apr 27;13(4):411-420. doi: 10.4254/wjh.v13.i4.411.ABSTRACTGiant cell hepatitis (GCH) is characterized by large and multinucleated (syncytial) hepatocytes in the context of liver inflammation. Infantile GCH is typically associated with autoimmune hemolytic anemia in the absence of any other systemic or organ-specific autoimmune comorbidity. The etiology is unknown; concomitant viral infections (as potential trigger factors) have been identified in a few patients. The pathogenesis reportedly relies upon immune-mediated/ autoimmune mechanisms. This condition should be considered in any infant developing ...
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Dimitri Poddighe Aidana Madiyeva Diana Talipova Balzhan Umirbekova Source Type: research

Long-term albumin infusion in decompensated cirrhosis: A review of current literature
World J Hepatol. 2021 Apr 27;13(4):421-432. doi: 10.4254/wjh.v13.i4.421.ABSTRACTDecompensated cirrhosis is characterized by chronic inflammation and severe portal hypertension leading to systemic circulatory dysfunction. Albumin infusion has been widely used in decompensated cirrhosis in patients with spontaneous bacterial peritonitis, large-volume paracentesis and hepatorenal syndrome. Emerging data suggest long-term albumin infusion has both oncotic and non-oncotic properties which may improve the clinical outcomes in decompensated cirrhosis patients. We review the current literature on both the established and potential...
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Yu Jun Wong Rahul Kumar Yu Jing Jonathan Chua Tiing Leong Ang Source Type: research

Bile acid indices as biomarkers for liver diseases I: Diagnostic markers
CONCLUSION: BA indices have much lower inter- and intra-individual variability compared to absolute BA concentrations and changes of BA indices are associated with the risk of developing liver diseases.PMID:33959226 | PMC:PMC8080550 | DOI:10.4254/wjh.v13.i4.433 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Jawaher Abdullah Alamoudi Wenkuan Li Nagsen Gautam Marco Olivera Jane Meza Sandeep Mukherjee Yazen Alnouti Source Type: research

Elderly patients ( ≥ 80 years) with acute calculous cholangitis have similar outcomes as non-elderly patients ( & lt; 80 years): Propensity score-matched analysis
CONCLUSION: Mortality is indifferent in the elderly (≥ 80 years old) and non-elderly patients (
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Kai Siang Chan Ramkumar Mohan Jee Keem Low Sameer P Junnarkar Cheong Wei Terence Huey Vishal G Shelat Source Type: research

Retrospective analysis of complications related to endoscopic retrograde cholangio-pancreatography in patients with cirrhosis < em > vs < /em > patients without cirrhosis
CONCLUSION: The results of our study reaffirm that liver cirrhosis has an impact on the occurrence of complications during ERCP. Our study shows that CP class seems to be more reliable as compared to MELD score in predicting complications of ERCP in cirrhosis patients.PMID:33959228 | PMC:PMC8080553 | DOI:10.4254/wjh.v13.i4.472 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Michelle Bernshteyn Linda Hu Umair Masood Anuj Vikrant Sharma Danning Huang Bishnu Sapkota Source Type: research

Fatal arterial hemorrhage after pancreaticoduodenectomy: How do we simultaneously accomplish complete hemostasis and hepatic arterial flow?
CONCLUSION: Transcatheter placement of a covered stent may be useful for simultaneous accomplishment of complete hemostasis and HA flow preservation.PMID:33959229 | PMC:PMC8080554 | DOI:10.4254/wjh.v13.i4.483 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Yasuyuki Kamada Tomohide Hori Hidekazu Yamamoto Hideki Harada Michihiro Yamamoto Masahiro Yamada Takefumi Yazawa Ben Sasaki Masaki Tani Asahi Sato Hikotaro Katsura Ryotaro Tani Ryuhei Aoyama Yudai Sasaki Masaharu Okada Masazumi Zaima Source Type: research

Dried blood spot sampling as an alternative for the improvement of hepatitis B and C diagnosis in key populations
CONCLUSION: DBS with electrochemiluminescence are useful tools for the diagnosis and prevalence studies of hepatitis B and C among key populations and may increase the opportunity to foster prevention and treatment.PMID:33959230 | PMC:PMC8080549 | DOI:10.4254/wjh.v13.i4.504 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Geane Lopes Flores Jakeline Ribeiro Barbosa Helena Medina Cruz Juliana Cust ódio Miguel Denise Vigo Potsch Jos é Henrique Pilotto Danielle Malta Lima Jeov á Keny Baima Colares Carlos Eduardo Brand ão-Mello Marcia Maria Amendola Pires Jurema Corr êa d Source Type: research

Asymptomatic portal vein aneurysm: Three case reports
CONCLUSION: As PVA remains asymptomatic in many cases, recognition of its imaging features is key to favourable outcomes.PMID:33959231 | PMC:PMC8080547 | DOI:10.4254/wjh.v13.i4.515 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Kateryna Priadko Marco Romano Luigi Maria Vitale Marco Niosi Ilario De Sio Source Type: research

Pathologic and molecular features of hepatocellular carcinoma: An update
World J Hepatol. 2021 Apr 27;13(4):393-410. doi: 10.4254/wjh.v13.i4.393.ABSTRACTMorphological diversity and several new distinct pathologic subtypes of hepatocellular carcinoma (HCC) are now well-recognized. Recent advances in tumor genomics and transcriptomics have identified several recurrent somatic/genetic alterations that are closely related with histomorphological subtypes and have therefore, greatly improved our understanding of HCC pathogenesis. Pathologic subtyping allows for a diagnosis which is clinically helpful and can have important implication in patient prognostication as some of these subtypes are extremel...
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Mukul Vij Julien Calderaro Source Type: research

Infantile giant cell hepatitis with autoimmune hemolytic anemia
World J Hepatol. 2021 Apr 27;13(4):411-420. doi: 10.4254/wjh.v13.i4.411.ABSTRACTGiant cell hepatitis (GCH) is characterized by large and multinucleated (syncytial) hepatocytes in the context of liver inflammation. Infantile GCH is typically associated with autoimmune hemolytic anemia in the absence of any other systemic or organ-specific autoimmune comorbidity. The etiology is unknown; concomitant viral infections (as potential trigger factors) have been identified in a few patients. The pathogenesis reportedly relies upon immune-mediated/ autoimmune mechanisms. This condition should be considered in any infant developing ...
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Dimitri Poddighe Aidana Madiyeva Diana Talipova Balzhan Umirbekova Source Type: research

Long-term albumin infusion in decompensated cirrhosis: A review of current literature
World J Hepatol. 2021 Apr 27;13(4):421-432. doi: 10.4254/wjh.v13.i4.421.ABSTRACTDecompensated cirrhosis is characterized by chronic inflammation and severe portal hypertension leading to systemic circulatory dysfunction. Albumin infusion has been widely used in decompensated cirrhosis in patients with spontaneous bacterial peritonitis, large-volume paracentesis and hepatorenal syndrome. Emerging data suggest long-term albumin infusion has both oncotic and non-oncotic properties which may improve the clinical outcomes in decompensated cirrhosis patients. We review the current literature on both the established and potential...
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Yu Jun Wong Rahul Kumar Yu Jing Jonathan Chua Tiing Leong Ang Source Type: research

Bile acid indices as biomarkers for liver diseases I: Diagnostic markers
CONCLUSION: BA indices have much lower inter- and intra-individual variability compared to absolute BA concentrations and changes of BA indices are associated with the risk of developing liver diseases.PMID:33959226 | PMC:PMC8080550 | DOI:10.4254/wjh.v13.i4.433 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Jawaher Abdullah Alamoudi Wenkuan Li Nagsen Gautam Marco Olivera Jane Meza Sandeep Mukherjee Yazen Alnouti Source Type: research

Elderly patients ( ≥ 80 years) with acute calculous cholangitis have similar outcomes as non-elderly patients ( & lt; 80 years): Propensity score-matched analysis
CONCLUSION: Mortality is indifferent in the elderly (≥ 80 years old) and non-elderly patients (
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Kai Siang Chan Ramkumar Mohan Jee Keem Low Sameer P Junnarkar Cheong Wei Terence Huey Vishal G Shelat Source Type: research

Retrospective analysis of complications related to endoscopic retrograde cholangio-pancreatography in patients with cirrhosis < em > vs < /em > patients without cirrhosis
CONCLUSION: The results of our study reaffirm that liver cirrhosis has an impact on the occurrence of complications during ERCP. Our study shows that CP class seems to be more reliable as compared to MELD score in predicting complications of ERCP in cirrhosis patients.PMID:33959228 | PMC:PMC8080553 | DOI:10.4254/wjh.v13.i4.472 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Michelle Bernshteyn Linda Hu Umair Masood Anuj Vikrant Sharma Danning Huang Bishnu Sapkota Source Type: research

Fatal arterial hemorrhage after pancreaticoduodenectomy: How do we simultaneously accomplish complete hemostasis and hepatic arterial flow?
CONCLUSION: Transcatheter placement of a covered stent may be useful for simultaneous accomplishment of complete hemostasis and HA flow preservation.PMID:33959229 | PMC:PMC8080554 | DOI:10.4254/wjh.v13.i4.483 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Yasuyuki Kamada Tomohide Hori Hidekazu Yamamoto Hideki Harada Michihiro Yamamoto Masahiro Yamada Takefumi Yazawa Ben Sasaki Masaki Tani Asahi Sato Hikotaro Katsura Ryotaro Tani Ryuhei Aoyama Yudai Sasaki Masaharu Okada Masazumi Zaima Source Type: research

Dried blood spot sampling as an alternative for the improvement of hepatitis B and C diagnosis in key populations
CONCLUSION: DBS with electrochemiluminescence are useful tools for the diagnosis and prevalence studies of hepatitis B and C among key populations and may increase the opportunity to foster prevention and treatment.PMID:33959230 | PMC:PMC8080549 | DOI:10.4254/wjh.v13.i4.504 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Geane Lopes Flores Jakeline Ribeiro Barbosa Helena Medina Cruz Juliana Cust ódio Miguel Denise Vigo Potsch Jos é Henrique Pilotto Danielle Malta Lima Jeov á Keny Baima Colares Carlos Eduardo Brand ão-Mello Marcia Maria Amendola Pires Jurema Corr êa d Source Type: research

Asymptomatic portal vein aneurysm: Three case reports
CONCLUSION: As PVA remains asymptomatic in many cases, recognition of its imaging features is key to favourable outcomes.PMID:33959231 | PMC:PMC8080547 | DOI:10.4254/wjh.v13.i4.515 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Kateryna Priadko Marco Romano Luigi Maria Vitale Marco Niosi Ilario De Sio Source Type: research

Pathologic and molecular features of hepatocellular carcinoma: An update
World J Hepatol. 2021 Apr 27;13(4):393-410. doi: 10.4254/wjh.v13.i4.393.ABSTRACTMorphological diversity and several new distinct pathologic subtypes of hepatocellular carcinoma (HCC) are now well-recognized. Recent advances in tumor genomics and transcriptomics have identified several recurrent somatic/genetic alterations that are closely related with histomorphological subtypes and have therefore, greatly improved our understanding of HCC pathogenesis. Pathologic subtyping allows for a diagnosis which is clinically helpful and can have important implication in patient prognostication as some of these subtypes are extremel...
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Mukul Vij Julien Calderaro Source Type: research

Infantile giant cell hepatitis with autoimmune hemolytic anemia
World J Hepatol. 2021 Apr 27;13(4):411-420. doi: 10.4254/wjh.v13.i4.411.ABSTRACTGiant cell hepatitis (GCH) is characterized by large and multinucleated (syncytial) hepatocytes in the context of liver inflammation. Infantile GCH is typically associated with autoimmune hemolytic anemia in the absence of any other systemic or organ-specific autoimmune comorbidity. The etiology is unknown; concomitant viral infections (as potential trigger factors) have been identified in a few patients. The pathogenesis reportedly relies upon immune-mediated/ autoimmune mechanisms. This condition should be considered in any infant developing ...
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Dimitri Poddighe Aidana Madiyeva Diana Talipova Balzhan Umirbekova Source Type: research

Long-term albumin infusion in decompensated cirrhosis: A review of current literature
World J Hepatol. 2021 Apr 27;13(4):421-432. doi: 10.4254/wjh.v13.i4.421.ABSTRACTDecompensated cirrhosis is characterized by chronic inflammation and severe portal hypertension leading to systemic circulatory dysfunction. Albumin infusion has been widely used in decompensated cirrhosis in patients with spontaneous bacterial peritonitis, large-volume paracentesis and hepatorenal syndrome. Emerging data suggest long-term albumin infusion has both oncotic and non-oncotic properties which may improve the clinical outcomes in decompensated cirrhosis patients. We review the current literature on both the established and potential...
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Yu Jun Wong Rahul Kumar Yu Jing Jonathan Chua Tiing Leong Ang Source Type: research

Bile acid indices as biomarkers for liver diseases I: Diagnostic markers
CONCLUSION: BA indices have much lower inter- and intra-individual variability compared to absolute BA concentrations and changes of BA indices are associated with the risk of developing liver diseases.PMID:33959226 | PMC:PMC8080550 | DOI:10.4254/wjh.v13.i4.433 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Jawaher Abdullah Alamoudi Wenkuan Li Nagsen Gautam Marco Olivera Jane Meza Sandeep Mukherjee Yazen Alnouti Source Type: research

Elderly patients ( ≥ 80 years) with acute calculous cholangitis have similar outcomes as non-elderly patients ( & lt; 80 years): Propensity score-matched analysis
CONCLUSION: Mortality is indifferent in the elderly (≥ 80 years old) and non-elderly patients (
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Kai Siang Chan Ramkumar Mohan Jee Keem Low Sameer P Junnarkar Cheong Wei Terence Huey Vishal G Shelat Source Type: research

Retrospective analysis of complications related to endoscopic retrograde cholangio-pancreatography in patients with cirrhosis < em > vs < /em > patients without cirrhosis
CONCLUSION: The results of our study reaffirm that liver cirrhosis has an impact on the occurrence of complications during ERCP. Our study shows that CP class seems to be more reliable as compared to MELD score in predicting complications of ERCP in cirrhosis patients.PMID:33959228 | PMC:PMC8080553 | DOI:10.4254/wjh.v13.i4.472 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Michelle Bernshteyn Linda Hu Umair Masood Anuj Vikrant Sharma Danning Huang Bishnu Sapkota Source Type: research

Fatal arterial hemorrhage after pancreaticoduodenectomy: How do we simultaneously accomplish complete hemostasis and hepatic arterial flow?
CONCLUSION: Transcatheter placement of a covered stent may be useful for simultaneous accomplishment of complete hemostasis and HA flow preservation.PMID:33959229 | PMC:PMC8080554 | DOI:10.4254/wjh.v13.i4.483 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Yasuyuki Kamada Tomohide Hori Hidekazu Yamamoto Hideki Harada Michihiro Yamamoto Masahiro Yamada Takefumi Yazawa Ben Sasaki Masaki Tani Asahi Sato Hikotaro Katsura Ryotaro Tani Ryuhei Aoyama Yudai Sasaki Masaharu Okada Masazumi Zaima Source Type: research

Dried blood spot sampling as an alternative for the improvement of hepatitis B and C diagnosis in key populations
CONCLUSION: DBS with electrochemiluminescence are useful tools for the diagnosis and prevalence studies of hepatitis B and C among key populations and may increase the opportunity to foster prevention and treatment.PMID:33959230 | PMC:PMC8080549 | DOI:10.4254/wjh.v13.i4.504 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Geane Lopes Flores Jakeline Ribeiro Barbosa Helena Medina Cruz Juliana Cust ódio Miguel Denise Vigo Potsch Jos é Henrique Pilotto Danielle Malta Lima Jeov á Keny Baima Colares Carlos Eduardo Brand ão-Mello Marcia Maria Amendola Pires Jurema Corr êa d Source Type: research

Asymptomatic portal vein aneurysm: Three case reports
CONCLUSION: As PVA remains asymptomatic in many cases, recognition of its imaging features is key to favourable outcomes.PMID:33959231 | PMC:PMC8080547 | DOI:10.4254/wjh.v13.i4.515 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Kateryna Priadko Marco Romano Luigi Maria Vitale Marco Niosi Ilario De Sio Source Type: research

Pathologic and molecular features of hepatocellular carcinoma: An update
World J Hepatol. 2021 Apr 27;13(4):393-410. doi: 10.4254/wjh.v13.i4.393.ABSTRACTMorphological diversity and several new distinct pathologic subtypes of hepatocellular carcinoma (HCC) are now well-recognized. Recent advances in tumor genomics and transcriptomics have identified several recurrent somatic/genetic alterations that are closely related with histomorphological subtypes and have therefore, greatly improved our understanding of HCC pathogenesis. Pathologic subtyping allows for a diagnosis which is clinically helpful and can have important implication in patient prognostication as some of these subtypes are extremel...
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Mukul Vij Julien Calderaro Source Type: research

Infantile giant cell hepatitis with autoimmune hemolytic anemia
World J Hepatol. 2021 Apr 27;13(4):411-420. doi: 10.4254/wjh.v13.i4.411.ABSTRACTGiant cell hepatitis (GCH) is characterized by large and multinucleated (syncytial) hepatocytes in the context of liver inflammation. Infantile GCH is typically associated with autoimmune hemolytic anemia in the absence of any other systemic or organ-specific autoimmune comorbidity. The etiology is unknown; concomitant viral infections (as potential trigger factors) have been identified in a few patients. The pathogenesis reportedly relies upon immune-mediated/ autoimmune mechanisms. This condition should be considered in any infant developing ...
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Dimitri Poddighe Aidana Madiyeva Diana Talipova Balzhan Umirbekova Source Type: research

Long-term albumin infusion in decompensated cirrhosis: A review of current literature
World J Hepatol. 2021 Apr 27;13(4):421-432. doi: 10.4254/wjh.v13.i4.421.ABSTRACTDecompensated cirrhosis is characterized by chronic inflammation and severe portal hypertension leading to systemic circulatory dysfunction. Albumin infusion has been widely used in decompensated cirrhosis in patients with spontaneous bacterial peritonitis, large-volume paracentesis and hepatorenal syndrome. Emerging data suggest long-term albumin infusion has both oncotic and non-oncotic properties which may improve the clinical outcomes in decompensated cirrhosis patients. We review the current literature on both the established and potential...
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Yu Jun Wong Rahul Kumar Yu Jing Jonathan Chua Tiing Leong Ang Source Type: research

Bile acid indices as biomarkers for liver diseases I: Diagnostic markers
CONCLUSION: BA indices have much lower inter- and intra-individual variability compared to absolute BA concentrations and changes of BA indices are associated with the risk of developing liver diseases.PMID:33959226 | PMC:PMC8080550 | DOI:10.4254/wjh.v13.i4.433 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Jawaher Abdullah Alamoudi Wenkuan Li Nagsen Gautam Marco Olivera Jane Meza Sandeep Mukherjee Yazen Alnouti Source Type: research

Elderly patients ( ≥ 80 years) with acute calculous cholangitis have similar outcomes as non-elderly patients ( & lt; 80 years): Propensity score-matched analysis
CONCLUSION: Mortality is indifferent in the elderly (≥ 80 years old) and non-elderly patients (
Source: World Journal of Hepatology - May 7, 2021 Category: Gastroenterology Authors: Kai Siang Chan Ramkumar Mohan Jee Keem Low Sameer P Junnarkar Cheong Wei Terence Huey Vishal G Shelat Source Type: research