Safety of direct acting antiviral treatment for hepatitis C in oncologic setting: A clinical experience and a literature review
World J Hepatol. 2022 Mar 27;14(3):525-534. doi: 10.4254/wjh.v14.i3.525.ABSTRACTWith a globally estimated 58 million people affected by, chronic hepatitis C virus (HCV) infection still represents a hard challenge for scientific community. A chronic course can occur among patients with a weak innate ad adaptive response with cirrhosis and malignancies as main consequences. Oncologic patients undergoing chemotherapy represent a special immunocompromised population predisposed to HCV reactivation (HCVr) with undesirable changes in cancer treatment and outcome. Aim of the study highlight the possibility of HCVr in oncologic po...
Source: World Journal of Hepatology - May 18, 2022 Category: Gastroenterology Authors: Anna Maria Spera Source Type: research

Prevalence of hypothyroidism and effect of thyroid hormone replacement therapy in patients with non-alcoholic fatty liver disease: A population-based study
CONCLUSION: Hypothyroidism seems to be an independent risk factor for the development of NAFLD. Thyroid hormone replacement did not provide a statistically significant risk reduction. Further studies are needed to evaluate the effect of thyroid hormone replacement and assess if being euthyroid while on thyroid replacement therapy affects development and/or progression of NAFLD.PMID:35582287 | PMC:PMC9055192 | DOI:10.4254/wjh.v14.i3.551 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 18, 2022 Category: Gastroenterology Authors: Ashraf Almomani Asif Ali Hitawala Prabhat Kumar Sura Alqaisi Dana Alshaikh Motasem Alkhayyat Imad Asaad Source Type: research

Standards of liver cirrhosis care in Central Australia
CONCLUSION: HCC or variceal surveillance programmes had less uptake amongst Aboriginal patients. Greater emphasis needs to be placed on eliminating cultural obstacles to accessing hepatology services.PMID:35582288 | PMC:PMC9055197 | DOI:10.4254/wjh.v14.i3.559 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 18, 2022 Category: Gastroenterology Authors: Sreecanth S Raja Robert G Batey Suzanne Edwards Hein H Aung Source Type: research

New progress in understanding roles of nitric oxide during hepatic ischemia-reperfusion injury
World J Hepatol. 2022 Mar 27;14(3):504-515. doi: 10.4254/wjh.v14.i3.504.ABSTRACTHepatic ischemia-reperfusion injury (HIRI) is a major clinical cause of morbidity and mortality in liver surgery and transplantation. Many studies have found that nitric oxide (NO) plays an important role in the HIRI and its increase or decrease can affect the progression and outcome of HIRI. However, the role of NO in HIRI is controversial and complicated. NO derived by endothelial NO synthase (eNOS) shows a protective role in HIRI, while excessive NO derived by inducible NO synthase (iNOS) accelerates inflammation and increases oxidative stre...
Source: World Journal of Hepatology - May 18, 2022 Category: Gastroenterology Authors: Yi-Ping Zhang Xin-Ran Liu Mei-Wen Yang Shu-Long Yang Fen-Fang Hong Source Type: research

Small duct primary sclerosing cholangitis: A discrete variant or a bridge to large duct disease, a practical review
World J Hepatol. 2022 Mar 27;14(3):495-503. doi: 10.4254/wjh.v14.i3.495.ABSTRACTThe natural history, associations with inflammatory bowel disease (IBD), and long-term outcomes of large duct primary sclerosing cholangitis (ldPSC) have been well documented. Small duct primary sclerosing cholangitis (sdPSC) is a much less common and relatively more benign variant. The natural history of sdPSC has been difficult to characterize given the limited number of studies in the literature especially with regards to the subset of patients who progress to large duct involvement. It has been unclear whether sdPSC represented a subset of ...
Source: World Journal of Hepatology - May 18, 2022 Category: Gastroenterology Authors: Christopher M Nguyen Kevin T Kline Heather L Stevenson Kashif Khan Sreeram Parupudi Source Type: research

Fertaric acid amends bisphenol A-induced toxicity, DNA breakdown, and histopathological changes in the liver, kidney, and testis
CONCLUSION: FA ameliorates BPA-induced liver, kidney, and testis toxicity, DNA breakdown, and histopathological changes.PMID:35582291 | PMC:PMC9055189 | DOI:10.4254/wjh.v14.i3.535 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 18, 2022 Category: Gastroenterology Authors: Khaled Mohamed Mohamed Koriem Source Type: research

Benign course of residual inflammation at end of treatment of liver transplant recipients after sofosbuvir based therapy
CONCLUSION: After successful HCV treatment with DAAs, liver transplant recipients may have persistent inflammation on biopsy without evidence of intracellular RNA. The clinical outcome remained favorable in most patients. Further studies with a larger number and longer follow-up are needed to establish the implication of this finding on long-term graft function.PMID:35582292 | PMC:PMC9055203 | DOI:10.4254/wjh.v14.i3.602 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 18, 2022 Category: Gastroenterology Authors: Bahaaeldeen Ismail Karim M Benrajab Pablo Bejarano Phillip Ruiz Debbie Sears Andreas Tzakis Xaralambos Bobby Zervos Source Type: research

Interrelationship between physical activity and depression in nonalcoholic fatty liver disease
CONCLUSION: Individuals with NAFLD have high levels of physical inactivity, particularly those with depressive symptoms. Because this group is at high risk for poor outcomes, practitioners should screen for the coexistence of depressive symptoms and NAFLD. This group should receive appropriate interventions aimed at increasing both participation and levels of intensity of physical activity.PMID:35582293 | PMC:PMC9055201 | DOI:10.4254/wjh.v14.i3.612 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 18, 2022 Category: Gastroenterology Authors: Ali A Weinstein Leyla De Avila Saisruthi Kannan James M Paik Pegah Golabi Lynn H Gerber Zobair M Younossi Source Type: research

Effect of a specific < em > Escherichia coli Nissle 1917 < /em > strain on minimal/mild hepatic encephalopathy treatment
CONCLUSION: The use of the probiotic EcN strain was safe and quite efficient for HE treatment. The probiotic reduced the ammonia content and the level of serum proinflammatory cytokines, normalized the gut microbiota composition and improved the cognitive function of patients with HE. The application of the EcN strain was more effective than lactulose treatment.PMID:35582294 | PMC:PMC9055191 | DOI:10.4254/wjh.v14.i3.634 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 18, 2022 Category: Gastroenterology Authors: Elina Manzhalii Valentyna Moyseyenko Vitalii Kondratiuk Nataliia Molochek Tetyana Falalyeyeva Nazarii Kobyliak Source Type: research

Assessment of fibroblast growth factor 19 as a non-invasive serum marker for hepatocellular carcinoma
CONCLUSION: FGF-19 represents a possible novel non-invasive marker for HCC. It may improve the prognosis of HCC patients due to its utility in several aspects of HCC detection and management.PMID:35582295 | PMC:PMC9055196 | DOI:10.4254/wjh.v14.i3.623 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 18, 2022 Category: Gastroenterology Authors: Ghada Abdelrahman Mohamed Ehab Hasan Nashaat Hadeer Mohamed Fawzy Ahmed Mohamed ElGhandour Source Type: research

Renal manifestations of hepatitis E among immunocompetent and solid organ transplant recipients
World J Hepatol. 2022 Mar 27;14(3):516-524. doi: 10.4254/wjh.v14.i3.516.ABSTRACTHepatitis E virus (HEV) infections are generally self-limited. Rare cases of hepatitis E induced fulminant liver failure requiring liver transplantation are reported in the literature. Even though HEV infection is generally encountered among developing countries, a recent uptrend is reported in developed countries. Consumption of unprocessed meat and zoonosis are considered to be the likely transmission modalities in developed countries. Renal involvement of HEV generally holds a benign and self-limited course. Although rare cases of cryoglobul...
Source: World Journal of Hepatology - May 18, 2022 Category: Gastroenterology Authors: Karthik Kovvuru Nicholas Carbajal Abhinandan Reddy Pakanati Charat Thongprayoon Panupong Hansrivijit Boonphiphop Boonpheng Pattharawin Pattharanitima Voravech Nissaisorakarn Wisit Cheungpasitporn Swetha R Kanduri Source Type: research

Predictors of mortality at 28-days in infection associated acute kidney injury in cirrhosis
CONCLUSION: Infection AKI in cirrhosis has a dismal prognosis with higher 28-d mortality as compared to non-infection AKI. Serum bilirubin and presence of HE predict 28-d mortality in infection AKI.PMID:35582297 | PMC:PMC9055202 | DOI:10.4254/wjh.v14.i3.592 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 18, 2022 Category: Gastroenterology Authors: Tarana Gupta Naveen Ranga Sandeep Kumar Goyal Source Type: research

Pediatric liver transplantation outcomes from a single center in Thailand
CONCLUSION: A significant number of pediatric LT cases were reported in Thailand. Based on relatively comparable outcomes, ABO-incompatible and HBc antibody-positive grafts may be considered in an organ shortage situation.PMID:35582298 | PMC:PMC9055198 | DOI:10.4254/wjh.v14.i3.583 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 18, 2022 Category: Gastroenterology Authors: Sittichoke Prachuapthunyachart Palittiya Sintusek Chomchanat Tubjareon Nataruks Chaijitraruch Anapat Sanpavat Teerasak Phewplung Piyaporn Wanawongsawad Ai-Lada Intrarakamhang Voranush Chongsrisawat Source Type: research

Hepatitis E in immunocompromised individuals
World J Hepatol. 2022 Mar 27;14(3):482-494. doi: 10.4254/wjh.v14.i3.482.ABSTRACTHepatitis E virus (HEV) originally identified as a cause of acute icteric hepatitis in developing countries has grown to be a cause of zoonotic viral hepatitis in developed countries such as the United States. While there are eight identified genotypes to date, genotype 1 (HEV1), HEV2, HEV3, HEV4 are the most common to infect humans. HEV1 and HEV2 are most common in developing countries including Latina America, Africa and Asia, and are commonly transmitted through contaminated water supplies leading to regional outbreaks. In contrast HEV3 and ...
Source: World Journal of Hepatology - May 18, 2022 Category: Gastroenterology Authors: Konstantinos Damiris Mohamad Aghaie Meybodi Mumtaz Niazi Nikolaos Pyrsopoulos Source Type: research

Risk factors and prediction of acute kidney injury after liver transplantation: Logistic regression and artificial neural network approaches
CONCLUSION: The severity of liver disease, pre-existing kidney dysfunction, marginal grafts, hemodynamic instability, MBT, and SL are predictors of postoperative AKI, and ANN has better prediction performance than LR in this scenario.PMID:35582300 | PMC:PMC9055199 | DOI:10.4254/wjh.v14.i3.570 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - May 18, 2022 Category: Gastroenterology Authors: Luis Cesar Bredt Luis Alberto Batista Peres Michel Risso Leandro Cavalcanti de Albuquerque Leite Barros Source Type: research