Oxidative stress in alcohol-related liver disease.
Authors: Tan HK, Yates E, Lilly K, Dhanda AD Abstract Alcohol consumption is one of the leading causes of the global burden of disease and results in high healthcare and economic costs. Heavy alcohol misuse leads to alcohol-related liver disease, which is responsible for a significant proportion of alcohol-attributable deaths globally. Other than reducing alcohol consumption, there are currently no effective treatments for alcohol-related liver disease. Oxidative stress refers to an imbalance in the production and elimination of reactive oxygen species and antioxidants. It plays important roles in several aspects o...
Source: World Journal of Hepatology - August 22, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Ipragliflozin-induced improvement of liver steatosis in obese mice may involve sirtuin signaling.
CONCLUSION: Our study suggests that the liver steatosis-ameliorating effects of ipragliflozin in ob/ob mice may be mediated partly by hepatic SIRT1 signaling, possibly through the PGC-1α/PPARα-FGF21 pathway. PMID: 32821334 [PubMed - as supplied by publisher] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - August 22, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Anti-inflammatory and anti-oxidant effects of aloe vera in rats with non-alcoholic steatohepatitis.
Authors: Klaikeaw N, Wongphoom J, Werawatganon D, Chayanupatkul M, Siriviriyakul P Abstract BACKGROUND: Aloe vera exerts several biological activities, such as, anti-inflammatory, antioxidant, and antimicrobial effects. It was recently shown to reduce insulin resistance and triglyceride level. We hypothesized that aloe vera would have beneficial effects in alleviating non-alcoholic steatohepatitis (NASH) in rats. AIM: To examine the therapeutic effects of aloe vera in NASH rats. METHODS: All rats were randomly divided into 3 groups (n = 6 in each group). Rats in the control group were fed ad libitum with a ...
Source: World Journal of Hepatology - August 22, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Non-alcoholic steatohepatitis and the risk of myocardial infarction: A population-based national study.
CONCLUSION: MI appears to be a prevalent disease in NASH. Patients with NASH may need early identification and aggressive cardiovascular risk modification. PMID: 32821336 [PubMed - as supplied by publisher] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - August 22, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Effect of zinc treatment on clinical outcomes in patients with liver cirrhosis: A systematic review and meta-analysis.
CONCLUSION: Zinc supplementation is not associated with reduced mortality in patients with cirrhosis. Findings are limited by the small number of eligible studies and significant heterogeneity in intervention and patient population. PMID: 32821337 [PubMed - as supplied by publisher] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - August 22, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Diagnosis and management of hepatic artery in-stent restenosis after liver transplantation by optical coherence tomography: A case report.
CONCLUSION: Intravascular diagnostic methods can be useful in evaluating cases in which initial angiography results are not sufficient to provide a proper diagnosis of significant stenosis, especially with regard to ISR. A wide range of diagnoses are provided by OCT, resulting in different treatment options. Interventional radiologists should consider intravascular diagnostic methods as additional tools for evaluating patients when visceral angiography results are unclear. PMID: 32821338 [PubMed - as supplied by publisher] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - August 22, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Is right lobe liver graft without main right hepatic vein suitable for living donor liver transplantation?
CONCLUSION: Thanks to this venous reconstruction model, none of the patients developed postoperative complications related to venous drainage. Our experience with venous drainage reconstruction models shows that congenital variations in the hepatic venous structure of living liver donors are not absolute contraindications for LDLT. PMID: 32821339 [PubMed - as supplied by publisher] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - August 22, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Endoscopic ultrasound in chronic liver disease.
Authors: Fung BM, Abadir AP, Eskandari A, Levy MJ, Tabibian JH Abstract Endoscopic ultrasound (EUS) is a minimally invasive diagnostic and therapeutic modality with a number of established as well as evolving uses in patients with chronic liver disease. Compared to other diagnostic tools such as cross-sectional imaging or conventional endoscopy, EUS has been shown to increase diagnostic sensitivity and therapeutic success for many clinical scenarios and applications with a low rate of adverse events. In this review, we discuss and focus on the current and growing role of EUS in the evaluation and/or treatment of he...
Source: World Journal of Hepatology - August 5, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Changing delta hepatitis patient profile: A single center experience in Valencia region, Spain.
CONCLUSION: Patients infected in the 1980's were mostly locals infected through intravenous drug use, whereas those diagnosed recently are frequently non-Spanish natives from endemic areas. Regardless of their origin, patients are predominantly male with significant comorbidities, which potentially play a major role in disease progression. We confirm a high rate of subsequent liver complications. PMID: 32742570 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - August 5, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Hospital teaching status on the outcomes of patients with esophageal variceal bleeding in the United States.
Authors: Patel P, Rotundo L, Orosz E, Afridi F, Pyrsopoulos N Abstract BACKGROUND: Acute variceal bleeding is a major complication of portal hypertension and is a leading cause of death in patients with cirrhosis. There is limited data on the outcomes of patients with esophageal variceal bleeding in teaching versus nonteaching hospitals. Because esophageal variceal bleeding requires complex management, it may be hypothesized that teaching hospitals have lower mortality. AIM: To assess the differences in mortality, hospital length of stay (LOS) and cost of admission for patients admitted for variceal bleed in te...
Source: World Journal of Hepatology - August 5, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

LIV-4: A novel model for predicting transplant-free survival in critically ill cirrhotics.
CONCLUSION: LIV-4, a validated model for predicting mortality in cirrhotic patients on admission to the ICU, performs better than alternative liver and ICU-specific survival scores. PMID: 32742572 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - August 5, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Low phospholipid-associated cholelithiasis syndrome: A rare cause of acute pancreatitis that should not be neglected.
CONCLUSION: LPAC syndrome is easy to diagnose and treat; therefore, it should no longer be overlooked. To increase its detection rate, all patients who experience recurrent biliary symptoms following an episode of acute pancreatitis should undergo an ultrasound examination performed by a radiologist with knowledge of the disease. PMID: 32742573 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - August 5, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Non-alcoholic fatty liver disease is not independent risk factor for cardiovascular disease event: A cohort study.
CONCLUSION: No independent association was detected between NAFLD and CVD. It is likely that diabetes mellitus and age may be the principle mediators in this regard. PMID: 32742574 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - August 5, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Geoepidemiologic variation in outcomes of primary sclerosing cholangitis.
Authors: Mehta TI, Weissman S, Fung BM, Tabibian JH Abstract Primary sclerosing cholangitis (PSC) is a chronic, progressive, hepatobiliary disease characterized by inflammation and fibrosis of the intra- and extra-hepatic bile ducts. Its natural history is one that generally progresses towards cirrhosis, liver failure, cholangiocarcinoma, and ultimately disease-related death, with a median liver transplantation-free survival time of approximately 15-20 years. However, despite its lethal nature, PSC remains a heterogenous disease with significant variability in outcomes amongst different regions of the world. There ...
Source: World Journal of Hepatology - July 22, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Liver injury induced by paracetamol and challenges associated with intentional and unintentional use.
Authors: Rotundo L, Pyrsopoulos N Abstract Drug induced liver injury (DILI) is a common cause of acute liver injury. Paracetamol, also known as acetaminophen, is a widely used anti-pyretic that has long been established to cause liver toxicity once above therapeutic levels. Hepatotoxicity from paracetamol overdose, whether intentional or non-intentional, is the most common cause of DILI in the United States and remains a global issue. Given the increased prevalence of combination medications in the form of pain relievers and antihistamines, paracetamol can be difficult to identify and remains a significant cause of...
Source: World Journal of Hepatology - July 22, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus.
Authors: da Silva CB, Vieira DA, de Melo LF, Chagas ALS, Gomes AD, de Faria CLL, Teixeira R, de Magalhães Queiroz DM, Rocha GA, Soares MMS, Bezerra JMT, Silva LD Abstract BACKGROUND: Chronic hepatitis C (CHC) is associated with type 2 diabetes mellitus. Although the pathogenesis remains to be elucidated, a growing evidence has suggested a role of pro-inflammatory immune response. Increased serum concentrations of Interleukin 6 (IL-6) have been associated with insulin resistance, type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection. AIM: To investigate the f...
Source: World Journal of Hepatology - July 22, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Comparison of four non-alcoholic fatty liver disease detection scores in a Caucasian population.
CONCLUSION: The four investigated NAFLD scores performed differently in the populationbased vs high-risk setting. FLI was preferable in the population-based setting, while LFS performed best in the high-risk setting. PMID: 32685107 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - July 22, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Combined endovascular-surgical treatment for complex congenital intrahepatic arterioportal fistula: A case report and review of the literature.
CONCLUSION: The combined radiological-surgical approach is a safe and effective treatment option for complex IAPF and avoids major invasive surgery. PMID: 32685108 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - July 22, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Inflammatory myofibroblastic tumor of the liver: A case report and review of literature.
CONCLUSION: IMTLs are extremely rare and difficult to diagnose. Due to their intermediate biological behavior, surgical resection should be perform whenever feasible and patients should be followed-up in order to detect recurrence and metastasis as early as possible. PMID: 32685109 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - July 22, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Pentadecapeptide BPC 157 resolves Pringle maneuver in rats, both ischemia and reperfusion.
CONCLUSION: BPC 157 resolves pringle maneuver-damage in rats, both for ischemia and reperfusion. PMID: 32547687 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - June 19, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Drug and herbal/dietary supplements-induced liver injury: A tertiary care center experience.
CONCLUSION: We describe the clinical findings, histopathological patterns of injury and clinical outcomes caused by drugs. In particular, we report a few previously unreported/ rarely observed clinical and histopathological patterns of hepatic injury. PMID: 32547688 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - June 19, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Usefulness of Mac-2 binding protein glycosylation isomer in non-invasive probing liver disease in the Vietnamese population.
CONCLUSION: M2BPGi was observed to be a good indicator of early liver disease in patients with different etiologies. Our results provide reference cut-offs for different causes of liver disease and demonstrated the utility of this marker for early disease monitoring. This is useful for remote regions in developing countries. PMID: 32547689 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - June 19, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Epidemiological profile of alcoholic liver disease hospital admissions in a Latin American country over a 10-year period.
CONCLUSION: Our study provides a landscape of the epidemiological profile of public hospital admissions due to ALD in Brazil. We detected an increase in the total number of admissions and deaths due to ALD over 10 years. PMID: 32547690 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - June 19, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Systemic review and network meta-analysis: Prophylactic antibiotic therapy for spontaneous bacterial peritonitis.
CONCLUSION: The present comprehensive network meta-analysis provides RCT based evidence for superior efficacy of rifaximin compared to other antibiotics for the prophylaxis of SBP and reducing risk of death/transplant. Further RCTs are warranted to confirm our findings. PMID: 32547691 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - June 19, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Transmission of cryptococcosis by liver transplantation: A case report and review of literature.
CONCLUSION: This case highlights the risk of transmission of fungal diseases, specifically of C. neoformans, through liver graft during liver transplantation. PMID: 32547692 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - June 19, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Polycystic liver disease: Classification, diagnosis, treatment process, and clinical management.
Authors: Zhang ZY, Wang ZM, Huang Y Abstract Polycystic liver disease (PLD) is a rare hereditary disease that independently exists in isolated PLD, or as an accompanying symptom of autosomal dominant polycystic kidney disease and autosomal recessive polycystic kidney disease with complicated mechanisms. PLD currently lacks a unified diagnostic standard. The diagnosis of PLD is usually made when the number of hepatic cysts is more than 20. Gigot classification and Schnelldorfer classification are now commonly used to define severity in PLD. Most PLD patients have no clinical symptoms, and minority with severe compli...
Source: World Journal of Hepatology - April 3, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells.
Authors: Ghazali R, Mehta KJ, Bligh SA, Tewfik I, Clemens D, Patel VB Abstract BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a common cause of liver disease worldwide and is a growing epidemic. A high ratio of omega-6 fatty acids to omega-3 fatty acids in the diet has been implicated in the development of NAFLD. However, the inflicted cellular pathology remains unknown. A high ratio may promote lipogenic pathways and contribute to reactive oxygen species (ROS)-mediated damage, perhaps leading to mitochondrial dysfunction. Therefore, these parameters were investigated to understand their contribution to N...
Source: World Journal of Hepatology - April 3, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Platelet-albumin-bilirubin score - a predictor of outcome of acute variceal bleeding in patients with cirrhosis.
CONCLUSION: PALBI score on admission is a good prognostic indicator for patients with acute variceal bleeding and predicts early mortality and rebleeding. PMID: 32231763 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 3, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Successful liver transplantation for acute sickle cell intrahepatic cholestasis: A case report and review of the literature.
CONCLUSION: This case highlights the utility of LT as a viable treatment option for acute sickle cell intrahepatic cholestasis. PMID: 32231764 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - April 3, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Clinical characteristics and treatment outcomes in patients with liver cirrhosis and lymphoma.
CONCLUSION: It may be possible to administer chemotherapy in selected cirrhotic patients, regardless of their severity, obtaining satisfactory clinical outcomes. Prospective clinical trials are needed to generate stronger recommendations. PMID: 32184940 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 20, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Early treatment efficacy of S-adenosylmethionine in patients with intrahepatic cholestasis: A systematic review.
CONCLUSION: Data from both randomized and non-randomized studies suggest that AdoMet improves some biochemical liver parameters and symptoms of cholestasis within 2 wk, with further improvements observed in some studies after 4 and 8 wk of treatment. PMID: 32184941 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 20, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Nonsense variant of ATP8B1 gene in heterozygosis and benign recurrent intrahepatic cholestasis: A case report and review of literature.
CONCLUSION: A genetic abnormality, different from those already known, could be involved in familial intrahepatic cholestatic disorders and/or pro-cholestatic genetic predisposition, thus encouraging further mutation detection in this field. PMID: 32184942 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 20, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Meeting report of the editorial board meeting for World Journal of Hepatology 2019.
In conclusion, it was noted that these new ideas expressed during the meeting will bring the WJH to the next level. In the future, the BPG and the editorial board will increase communication and collaboration in order to further the development of the WJH. PMID: 31984115 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - January 29, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Concise review of machine perfusion in liver transplantation.
Authors: Desai CS, Gerber DA Abstract With the advances and clinical growth in liver transplantation over the last four decades the focus on expanding deceased donor organs has been in need of scientific research. In the past ten years several researchers have looked at the domain of machine perfusion as it applies to deceased donor livers. The following review focuses on the clinical trials and recent advances that will likely have the earliest entrance into the clinical arena. PMID: 31984116 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - January 29, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Lessons from "real life experience" of rifaximin use in the management of recurrent hepatic encephalopathy.
CONCLUSION: In this real-life experience, the effectiveness of rifaximin was confirmed in the prevention of HE episodes recurrence but was not proved in the prevention of acute exacerbations recurrence on persistent HE. PMID: 31984117 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - January 29, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Imaging response predictors following drug eluting beads chemoembolization in the neoadjuvant liver transplant treatment of hepatocellular carcinoma.
Authors: Galastri FL, Nasser F, Affonso BB, Valle LGM, Odísio BC, Motta-Leal Filho JM, Salvalaggio PR, Garcia RG, de Almeida MD, Baroni RH, Wolosker N Abstract BACKGROUND: Drug-eluting bead transarterial chemoembolization (DEB-TACE) is an endovascular treatment to release chemotherapeutic agents within a target lesion, minimizing systemic exposure and adverse effects to chemotherapeutics. Therefore, identifying which patient characteristics may predict imaging response to DEB-TACE can improve treatment results while selecting the best candidates. Predictors of the response after DEB-TACE still have not been ...
Source: World Journal of Hepatology - January 29, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Post-infantile giant cell hepatitis: A single center's experience over 25 years.
CONCLUSION: The diagnosis of PIGCH remains clinically challenging and requires a high index of suspicion as well as a thorough history, physical examination, serological workup and liver biopsy. Treatment of the underlying cause can result in clinical stability in a large number of cases. PMID: 31966907 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - January 24, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Lumacaftor/ivacaftor therapy is associated with reduced hepatic steatosis in cystic fibrosis patients.
CONCLUSION: Use of the CFTR modulator lumacaftor/ivacaftor was associated with significantly lower hepatic steatosis. No association between CFRD and hepatic steatosis was found in this cohort. PMID: 31966908 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - January 24, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Intrahepatic and intra-abdominal splenosis: A case report and review of literature.
CONCLUSION: Scintigraphy with Tc-99 DRBC is a reliable technique to diagnose splenosis and should be performed before using more invasive procedures are carried out. Splenosis should be considered as a possible differential diagnosis for a hepatic nodule in any patient with a history of abdominal trauma, previous splenectomy or atypical radiological features on imaging. PMID: 31966909 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - January 24, 2020 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Gastric food retention at endoscopy is associated with severity of liver cirrhosis.
Authors: Snell DB, Cohen-Mekelburg S, Weg R, Ghosh G, Buckholz AP, Mehta A, Ma X, Christos PJ, Jesudian AB Abstract BACKGROUND: Gastrointestinal symptoms are prevalent in patients with cirrhosis. Cirrhotic patients have a known predilection to delayed gastric emptying compared to those without cirrhosis. However, the contributing factors have not been fully elucidated. Retained gastric food on esophagogastroduodenoscopy (EGD) has been used as a surrogate marker for delayed gastric emptying with reasonably high specificity. Therefore, we hypothesize that the frequency of retained gastric food contents at EGD will be...
Source: World Journal of Hepatology - November 28, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Hepatotoxicity associated with Garcinia cambogia: A case report.
CONCLUSION: Medical reconciliation of HS should be performed in patients with suspected acute liver failure and early discontinuation of HS can prevent further progression of drug induced hepatoxicity. PMID: 31772720 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - November 28, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Cholangiocarcinoma after flow diversion surgery for congenital biliary dilatation: A case report and review of literature.
CONCLUSION: This case suggests the necessity of careful observation after flow diversion surgery, especially when PBM with CBD is detected in adulthood. PMID: 31772721 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - November 28, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Impact on 30-d readmissions for cirrhotic patients with ascites after an educational intervention: A pilot study.
CONCLUSION: Medical education has the potential to improve clinical outcomes in patients admitted to hospital with cirrhosis and ascites. PMID: 31749900 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - November 23, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Characterization of patients with both alcoholic and nonalcoholic fatty liver disease in a large United States cohort.
CONCLUSION: A significant percentage of the American general population is afflicted by BAFLD and these patients tend to have more advanced liver fibrosis. PMID: 31749901 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - November 23, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Escitalopram-induced liver injury: A case report and review of literature.
CONCLUSION: Clinicians should be aware of the possibility of escitalopram-induced liver injury when initiating depressed patients on antidepressant treatment. This requires extra vigilance as most patients may remain asymptomatic. Measurement of liver function tests could be considered after initiation of antidepressant treatment, especially in patients with pre-existing liver disease. PMID: 31749902 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - November 23, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Cirrhotic patients and older people.
Authors: Carrier P, Debette-Gratien M, Jacques J, Loustaud-Ratti V Abstract The global population is aging, and so the number of older cirrhotic patients is increasing. Older patients are characterised by a risk of frailty and comorbidities, and age is a risk factor for mortality in cirrhotic patients. The incidence of non-alcoholic fatty liver disease as an aetiology of cirrhosis is increasing, while that of chronic viral hepatitis is decreasing. Also, cirrhosis is frequently idiopathic. The management of portal hypertension in older cirrhotic patients is similar to that in younger patients, despite the greater ri...
Source: World Journal of Hepatology - October 12, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Hepatic flow is an intraoperative predictor of early allograft dysfunction in whole-graft deceased donor liver transplantation: An observational cohort study.
CONCLUSION: Intraoperative measurement of blood flow after reperfusion appears to be a predictor of EAD; Moreover, HAF should be considered a predictor of 30-d patient mortality. PMID: 31598193 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - October 12, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Hepatocellular carcinoma staging systems: Hong Kong liver cancer vs Barcelona clinic liver cancer in a Western population.
CONCLUSION: In a Western population, the general agreement between the two systems was 80.0%, although in BCLC-B cases the agreement was low, suggesting that some individuals could be candidates for the curative treatment recommended by the HKLC. The authors suggest that the BCLC system should be routinely employed, although for BCLC-B cases it should be associated with the HKLC system. PMID: 31602288 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - October 12, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Is porto sinusoidal vascular disease to be actively searched in patients with portal vein thrombosis?
In conclusion, even if it is still totally hypothetical, our point of view may have clinical consequences, especially when deciding to perform a liver biopsy in patients with a higher liver stiffness and suspending the anticoagulation in patients with PVT and no detectable prothrombotic factors. PMID: 31528244 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - September 19, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research

Prolonged high-fat-diet feeding promotes non-alcoholic fatty liver disease and alters gut microbiota in mice.
CONCLUSION: Overall, these data suggest that chronic HFD consumption in mice can mimic pathophysiological and some microbial events observed in NAFLD patients. PMID: 31528245 [PubMed] (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - September 19, 2019 Category: Gastroenterology Tags: World J Hepatol Source Type: research