Effects of SARS-CoV-2 infection on incidence and treatment strategies of hepatocellular carcinoma in people with chronic liver disease
CONCLUSION: Although CLD patients with SARS-CoV-2 infection were not associated with increased risk of HCC, they were more likely to receive palliative treatment than those without. The detrimental effects of SARS-CoV-2 infection persisted in post-acute phase.PMID:38495273 | PMC:PMC10941734 | DOI:10.4254/wjh.v16.i2.211 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Lung-Yi Mak Matthew Shing Hin Chung Xue Li Francisco Tsz Tsun Lai Eric Yuk Fai Wan Celine Sze Ling Chui Franco Wing Tak Cheng Esther Wai Yin Chan Ching Lung Cheung Ivan Chi Ho Au Xi Xiong Wai-Kay Seto Man-Fung Yuen Carlos King Ho Wong Ian Chi Kei Wong Source Type: research
Evaluation of G3BP1 in the prognosis of acute and acute-on-chronic liver failure after the treatment of artificial liver support system
CONCLUSION: This study indicated that G3BP1 could predict the prognosis of ALF or ACLF patients treated with ALSS. The combination of G3BP1, AFP and LDH could accurately evaluate the disease condition and predict the clinical endpoint of patients.PMID:38495274 | PMC:PMC10941744 | DOI:10.4254/wjh.v16.i2.251 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Wen-Yuan Li Lu-Wen Wang Jin Dong Yao Wang Source Type: research
New markers of fibrosis in hepatitis C: A step towards the Holy Grail?
World J Hepatol. 2024 Feb 27;16(2):112-114. doi: 10.4254/wjh.v16.i2.112.ABSTRACTIn the present issue of the World Journal of Hepatology, Ferrassi et al examine the problem of liver fibrosis staging in chronic hepatitis C. They identify novel biomarkers in an effort to predict accurate fibrosis staging with the aid of the metabolome of Hepatitis C patients. Overall I think Ferrassi et al took a different approach in identifying fibrosis biomarkers, by looking at the patients' metabolome. Their biomarkers clearly separate patients from controls. They can also separate out, patients with minimal fibrosis (F0-F1 stage) and pat...
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Konstantinos John Dabos Source Type: research
Coinfection with hepatic cystic and alveolar echinococcosis with abdominal wall abscess and sinus tract formation: A case report
CONCLUSION: Lesions involving the abdominal wall and sinus tract formation, may require radical resection. Long-term prognosis includes albendazole and follow-up examinations.PMID:38495276 | PMC:PMC10941752 | DOI:10.4254/wjh.v16.i2.279 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Miao-Miao Wang Xiu-Qing An Jin-Ping Chai Jin-Yu Yang Ji-De A Xiang-Ren A Source Type: research
Dynamic changes and clinical value of lipocalin 2 in liver diseases caused by microbial infections
World J Hepatol. 2024 Feb 27;16(2):177-185. doi: 10.4254/wjh.v16.i2.177.ABSTRACTLipocalin 2 (LCN2) plays a pivotal role in iron metabolism, particularly in the context of microbial infection resistance (e.g., viruses, bacteria, parasites, etc.). LCN2 combats microbial infection by directly assisting the body in competing with microorganisms for iron, inducing immune cells to secrete various cytokines to enhance systemic immune responses, or recruiting neutrophils to infectious sites. The liver serves as the primary organ for LCN2 secretion during microbial infections. This review encapsulates recent advances in dynamic cha...
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Feng Chen Shan-Shan Wu Chao Chen Cheng Zhou Source Type: research
Anti-oxidative stress treatment and current clinical trials
World J Hepatol. 2024 Feb 27;16(2):294-299. doi: 10.4254/wjh.v16.i2.294.ABSTRACTOxidative stress disturbs the balance between the production of reactive oxygen species (ROS) and the detoxification biological process. It plays an important role in the development and progression of many chronic diseases. Upon exposure to oxidative stress or the inducers of ROS, the cellular nucleus undergoes some biological processes via different signaling pathways, such as stress adaption through the forkhead box O signaling pathway, inflammatory response through the IκB kinase/nuclear factor-κB signaling pathway, hypoxic response via t...
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Chun-Ye Zhang Ming Yang Source Type: research
Insights into skullcap herb-induced liver injury
World J Hepatol. 2024 Feb 27;16(2):120-122. doi: 10.4254/wjh.v16.i2.120.ABSTRACTThis editorial addresses the growing concern of herb-induced liver injury (HILI), focusing on a unique case of Skullcap-induced HILI report. This editorial underscore the significant mortality rate linked to Skullcap-induced HILI, emphasizing the importance of vigilant monitoring and intervention. As herbal supplement usage rises, collaboration among clinicians and researchers is crucial to comprehend and address the complexities of HILI, particularly those involving Skullcap.PMID:38495279 | PMC:PMC10941739 | DOI:10.4254/wjh.v16.i2.120 (Source:...
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Jonathan Soldera Source Type: research
Advancements in autoimmune hepatitis management: Perspectives for future guidelines
World J Hepatol. 2024 Feb 27;16(2):135-139. doi: 10.4254/wjh.v16.i2.135.ABSTRACTThe first-line treatment for autoimmune hepatitis involves the use of prednisone or prednisolone either as monotherapy or in combination with azathioprine (AZA). Budesonide has shown promise in inducing a complete biochemical response (CBR) with fewer adverse effects and is considered an optional first-line treatment, particularly for patients without cirrhosis; however, it is worth noting that the design of that study favored budesonide. A recent real-life study revealed higher CBR rates with prednisone when equivalent initial doses were admin...
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Marcos Mucenic Source Type: research
Can rifaximin for hepatic encephalopathy be discontinued during broad-spectrum antibiotic treatment?
World J Hepatol. 2024 Feb 27;16(2):115-119. doi: 10.4254/wjh.v16.i2.115.ABSTRACTHepatic encephalopathy (HE) is a formidable complication in patients with decompensated cirrhosis, often necessitating the administration of rifaximin (RFX) for effective management. RFX, is a gut-restricted, poorly-absorbable oral rifamycin derived antibiotic that can be used in addition to lactulose for the secondary prophylaxis of HE. It has shown notable reductions in infection, hospital readmission, duration of hospital stay, and mortality. However, limited data exist about the concurrent use of RFX with broad-spectrum antibiotics, because...
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Chien-Hao Huang Piero Amodio Source Type: research
Precision targeting in hepatocellular carcinoma: Exploring ligand-receptor mediated nanotherapy
World J Hepatol. 2024 Feb 27;16(2):164-176. doi: 10.4254/wjh.v16.i2.164.ABSTRACTHepatocellular carcinoma (HCC) is the most common primary liver cancer and poses a major challenge to global health due to its high morbidity and mortality. Conventional chemotherapy is usually targeted to patients with intermediate to advanced stages, but it is often ineffective and suffers from problems such as multidrug resistance, rapid drug clearance, nonspecific targeting, high side effects, and low drug accumulation in tumor cells. In response to these limitations, recent advances in nanoparticle-mediated targeted drug delivery technolog...
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Xia-Qing Zhou Ya-Ping Li Shuang-Suo Dang Source Type: research
Changes in the etiology of liver cirrhosis and the corresponding management strategies
This article focuses particularly on the prevalence and trends in the etiology of liver cirrhosis (LC), prognosis for patients suffering from cirrhosis-related complications and hepatocellular carcinoma (HCC), and management strategies. The etiology of cirrhosis varies according to geographical, economic, and population factors. Viral hepatitis is the dominant cause in China. Vaccination and effective treatment have reduced the number of people with viral hepatitis, but the overall number is still large. Patients with viral hepatitis who progress over time to LC and HCC remain an important population to manage. The increas...
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Jin-Jin Dai Yue-Ying Liu Zhen-Hua Zhang Source Type: research
Autoimmune hepatitis and primary sclerosing cholangitis after direct-acting antiviral treatment for hepatitis C virus: A case report
CONCLUSION: The potential risk of developing autoimmune liver diseases after DAA treatment should be considered.PMID:38495284 | PMC:PMC10941733 | DOI:10.4254/wjh.v16.i2.286 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Yoshiki Morihisa Hobyung Chung Shuichiro Towatari Daisuke Yamashita Tetsuro Inokuma Source Type: research
Interleukins in liver disease treatment
World J Hepatol. 2024 Feb 27;16(2):140-145. doi: 10.4254/wjh.v16.i2.140.ABSTRACTCytokines play pleiotropic roles in human health and disease by regulating both innate and adaptive immune responses. Interleukins (ILs), a large group of cytokines, can be divided into seven families, including IL-1, IL-2, IL-6, IL-8, IL-10, IL-12, and IL-17 families. Here, we review the functions of ILs in the pathogenesis and resolution of liver diseases, such as liver inflammation (e.g., IL-35), alcohol-related liver disease (e.g., IL-11), non-alcoholic steatohepatitis (e.g., IL-22), liver fibrosis (e.g., Il-17a), and liver cancer (e.g., IL...
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Ming Yang Chun-Ye Zhang Source Type: research
Contemporary concepts of prevention and management of gastroesophageal variceal bleeding in liver cirrhosis patients
World J Hepatol. 2024 Feb 27;16(2):126-134. doi: 10.4254/wjh.v16.i2.126.ABSTRACTThis editorial describes the contemporary concepts of prevention and management of gastroesophageal variceal bleeding in liver cirrhosis (LC) patients according to the current guidelines. Gastroesophageal variceal bleeding is the most dangerous complication of portal hypertension in LC patients. Risk stratification and determination of an individual approach to the choice of therapeutic measures aimed at their prevention and management has emerged as one of the top concerns in modern hepatology. According to the current guidelines, in the absen...
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Dmitry Victorovich Garbuzenko Source Type: research
Metabolic-associated fatty liver disease and sarcopenia: A double whammy
World J Hepatol. 2024 Feb 27;16(2):152-163. doi: 10.4254/wjh.v16.i2.152.ABSTRACTThe prevalence of metabolic-associated fatty liver disease (MAFLD) has increased substantially in recent years because of the global obesity pandemic. MAFLD, now recognized as the number one cause of chronic liver disease in the world, not only increases liver-related morbidity and mortality among sufferers but also worsens the complications associated with other comorbid conditions such as cardiovascular disease, type 2 diabetes mellitus, obstructive sleep apnoea, lipid disorders and sarcopenia. Understanding the interplay between MAFLD and th...
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Aditya Viswanath Sherouk Fouda Cornelius James Fernandez Joseph M Pappachan Source Type: research
