Recent advances in the diagnosis of drug-induced liver injury
World J Hepatol. 2024 Feb 27;16(2):186-192. doi: 10.4254/wjh.v16.i2.186.ABSTRACTDrug-induced liver injury (DILI) is a major problem in the United States, commonly leading to hospital admission. Diagnosing DILI is difficult as it is a diagnosis of exclusion requiring a temporal relationship between drug exposure and liver injury and a thorough work up for other causes. In addition, DILI has a very variable clinical and histologic presentation that can mimic many different etiologies of liver disease. Objective scoring systems can assess the probability that a drug caused the liver injury but liver biopsy findings are not pa...
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Taqwa Ahmed Jawad Ahmad Source Type: research
Effects of SARS-CoV-2 infection on incidence and treatment strategies of hepatocellular carcinoma in people with chronic liver disease
CONCLUSION: Although CLD patients with SARS-CoV-2 infection were not associated with increased risk of HCC, they were more likely to receive palliative treatment than those without. The detrimental effects of SARS-CoV-2 infection persisted in post-acute phase.PMID:38495273 | PMC:PMC10941734 | DOI:10.4254/wjh.v16.i2.211 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Lung-Yi Mak Matthew Shing Hin Chung Xue Li Francisco Tsz Tsun Lai Eric Yuk Fai Wan Celine Sze Ling Chui Franco Wing Tak Cheng Esther Wai Yin Chan Ching Lung Cheung Ivan Chi Ho Au Xi Xiong Wai-Kay Seto Man-Fung Yuen Carlos King Ho Wong Ian Chi Kei Wong Source Type: research
Evaluation of G3BP1 in the prognosis of acute and acute-on-chronic liver failure after the treatment of artificial liver support system
CONCLUSION: This study indicated that G3BP1 could predict the prognosis of ALF or ACLF patients treated with ALSS. The combination of G3BP1, AFP and LDH could accurately evaluate the disease condition and predict the clinical endpoint of patients.PMID:38495274 | PMC:PMC10941744 | DOI:10.4254/wjh.v16.i2.251 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Wen-Yuan Li Lu-Wen Wang Jin Dong Yao Wang Source Type: research
New markers of fibrosis in hepatitis C: A step towards the Holy Grail?
World J Hepatol. 2024 Feb 27;16(2):112-114. doi: 10.4254/wjh.v16.i2.112.ABSTRACTIn the present issue of the World Journal of Hepatology, Ferrassi et al examine the problem of liver fibrosis staging in chronic hepatitis C. They identify novel biomarkers in an effort to predict accurate fibrosis staging with the aid of the metabolome of Hepatitis C patients. Overall I think Ferrassi et al took a different approach in identifying fibrosis biomarkers, by looking at the patients' metabolome. Their biomarkers clearly separate patients from controls. They can also separate out, patients with minimal fibrosis (F0-F1 stage) and pat...
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Konstantinos John Dabos Source Type: research
Coinfection with hepatic cystic and alveolar echinococcosis with abdominal wall abscess and sinus tract formation: A case report
CONCLUSION: Lesions involving the abdominal wall and sinus tract formation, may require radical resection. Long-term prognosis includes albendazole and follow-up examinations.PMID:38495276 | PMC:PMC10941752 | DOI:10.4254/wjh.v16.i2.279 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Miao-Miao Wang Xiu-Qing An Jin-Ping Chai Jin-Yu Yang Ji-De A Xiang-Ren A Source Type: research
