Precision targeting in hepatocellular carcinoma: Exploring ligand-receptor mediated nanotherapy
World J Hepatol. 2024 Feb 27;16(2):164-176. doi: 10.4254/wjh.v16.i2.164.ABSTRACTHepatocellular carcinoma (HCC) is the most common primary liver cancer and poses a major challenge to global health due to its high morbidity and mortality. Conventional chemotherapy is usually targeted to patients with intermediate to advanced stages, but it is often ineffective and suffers from problems such as multidrug resistance, rapid drug clearance, nonspecific targeting, high side effects, and low drug accumulation in tumor cells. In response to these limitations, recent advances in nanoparticle-mediated targeted drug delivery technolog...
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Xia-Qing Zhou Ya-Ping Li Shuang-Suo Dang Source Type: research
Changes in the etiology of liver cirrhosis and the corresponding management strategies
This article focuses particularly on the prevalence and trends in the etiology of liver cirrhosis (LC), prognosis for patients suffering from cirrhosis-related complications and hepatocellular carcinoma (HCC), and management strategies. The etiology of cirrhosis varies according to geographical, economic, and population factors. Viral hepatitis is the dominant cause in China. Vaccination and effective treatment have reduced the number of people with viral hepatitis, but the overall number is still large. Patients with viral hepatitis who progress over time to LC and HCC remain an important population to manage. The increas...
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Jin-Jin Dai Yue-Ying Liu Zhen-Hua Zhang Source Type: research
Autoimmune hepatitis and primary sclerosing cholangitis after direct-acting antiviral treatment for hepatitis C virus: A case report
CONCLUSION: The potential risk of developing autoimmune liver diseases after DAA treatment should be considered.PMID:38495284 | PMC:PMC10941733 | DOI:10.4254/wjh.v16.i2.286 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Yoshiki Morihisa Hobyung Chung Shuichiro Towatari Daisuke Yamashita Tetsuro Inokuma Source Type: research
Interleukins in liver disease treatment
World J Hepatol. 2024 Feb 27;16(2):140-145. doi: 10.4254/wjh.v16.i2.140.ABSTRACTCytokines play pleiotropic roles in human health and disease by regulating both innate and adaptive immune responses. Interleukins (ILs), a large group of cytokines, can be divided into seven families, including IL-1, IL-2, IL-6, IL-8, IL-10, IL-12, and IL-17 families. Here, we review the functions of ILs in the pathogenesis and resolution of liver diseases, such as liver inflammation (e.g., IL-35), alcohol-related liver disease (e.g., IL-11), non-alcoholic steatohepatitis (e.g., IL-22), liver fibrosis (e.g., Il-17a), and liver cancer (e.g., IL...
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Ming Yang Chun-Ye Zhang Source Type: research
Contemporary concepts of prevention and management of gastroesophageal variceal bleeding in liver cirrhosis patients
World J Hepatol. 2024 Feb 27;16(2):126-134. doi: 10.4254/wjh.v16.i2.126.ABSTRACTThis editorial describes the contemporary concepts of prevention and management of gastroesophageal variceal bleeding in liver cirrhosis (LC) patients according to the current guidelines. Gastroesophageal variceal bleeding is the most dangerous complication of portal hypertension in LC patients. Risk stratification and determination of an individual approach to the choice of therapeutic measures aimed at their prevention and management has emerged as one of the top concerns in modern hepatology. According to the current guidelines, in the absen...
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Dmitry Victorovich Garbuzenko Source Type: research
Metabolic-associated fatty liver disease and sarcopenia: A double whammy
World J Hepatol. 2024 Feb 27;16(2):152-163. doi: 10.4254/wjh.v16.i2.152.ABSTRACTThe prevalence of metabolic-associated fatty liver disease (MAFLD) has increased substantially in recent years because of the global obesity pandemic. MAFLD, now recognized as the number one cause of chronic liver disease in the world, not only increases liver-related morbidity and mortality among sufferers but also worsens the complications associated with other comorbid conditions such as cardiovascular disease, type 2 diabetes mellitus, obstructive sleep apnoea, lipid disorders and sarcopenia. Understanding the interplay between MAFLD and th...
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Aditya Viswanath Sherouk Fouda Cornelius James Fernandez Joseph M Pappachan Source Type: research
Predicting major adverse cardiovascular events after orthotopic liver transplantation using a supervised machine learning model: A cohort study
CONCLUSION: Our study successfully assessed the feasibility and accuracy of the XGBoost machine learning model in predicting post-LT MACE, using both cardiovascular and hepatic variables. The model demonstrated impressive performance, aligning with literature findings, and exhibited excellent calibration. Notably, our cautious approach to prevent overfitting and data leakage suggests the stability of results when applied to prospective data, reinforcing the model's value as a reliable tool for predicting post-LT MACE in clinical practice.PMID:38495288 | PMC:PMC10941741 | DOI:10.4254/wjh.v16.i2.193 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Jonathan Soldera Leandro Luis Corso Matheus Machado Rech Vin ícius Remus Ballotin Lucas Goldmann Bigarella Fernanda Tom é Nathalia Moraes Rafael Sartori Balbinot Santiago Rodriguez Ajacio Bandeira de Mello Brand ão Bruno Hochhegger Source Type: research
Non-invasive assessment of esophageal varices: Status of today
World J Hepatol. 2024 Feb 27;16(2):123-125. doi: 10.4254/wjh.v16.i2.123.ABSTRACTWith increasing burden of compensated cirrhosis, we desperately need non-invasive methods for assessment of clinically significant portal hypertension. The use of liver and spleen stiffness measurement helps in deferring unnecessary endoscopies for low risk esophageal varices. This would reduce cost and patient discomfort. However, these special techniques may not be feasible at remote areas where still we need only biochemical parameters. More prospective studies validating the non-invasive risk prediction models are definitely needed.PMID:384...
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Tarana Gupta Source Type: research
Epidemiological survey of cystic echinococcosis in southwest China: From the Qinghai-Tibet plateau to the area of Yunnan
CONCLUSION: Cases of echinococcosis were reported throughout the entire Yunnan province, with the majority distributed in Western Yunnan, suggesting that echinococcosis control should be strengthened in this area. We suggest that an epidemiological investigation should be carried out in the future, based on the clues from newly discovered cases in hospitals or from the CISDCP. The newly discovered cases in the hospital provided clues to comprehensively determine the location of cases and where epidemic spot investigation should be conducted.PMID:38495269 | PMC:PMC10941742 | DOI:10.4254/wjh.v16.i2.229 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Jin-Rong Zi Dan Xiao Jia Peng Fang-Wei Wu Jian-Xiong Li Xin-Liu Yan Zheng-Qing Wang Xuan Cai Qian Xu Ben-Fu Li Ya-Ming Yang Source Type: research
Predictors of portal vein thrombosis after splenectomy in patients with cirrhosis
CONCLUSION: Wider PVD and MELD score > 10 were independent predictors of PVT at 1 months, 3 months, and 12 months after splenectomy in patient with cirrhosis.PMID:38495270 | PMC:PMC10941749 | DOI:10.4254/wjh.v16.i2.241 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Ting Li Li-Li Wang Ya-Ping Li Jian Gan Xi-Sheng Wei Xiao-Rong Mao Jun-Feng Li Source Type: research
Yinhuang granule alleviates carbon tetrachloride-induced liver fibrosis in mice and its mechanism
CONCLUSION: YHG effectively attenuates CCl4-induced liver fibrosis in mice by inhibiting the activation of HSCs, reducing inflammation, alleviating liver oxidative stress damage through Nrf2 activation, and promoting liver mitochondrial biogenesis.PMID:38495271 | PMC:PMC10941736 | DOI:10.4254/wjh.v16.i2.264 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Hao Ouyang Hui Miao Zhen Li Duan Wu Si-Cheng Gao Yao-Yao Dai Xiao-Di Gao Hai-Sheng Chai Wei-Ye Hu Jun-Feng Zhu Source Type: research
Recent advances in the diagnosis of drug-induced liver injury
World J Hepatol. 2024 Feb 27;16(2):186-192. doi: 10.4254/wjh.v16.i2.186.ABSTRACTDrug-induced liver injury (DILI) is a major problem in the United States, commonly leading to hospital admission. Diagnosing DILI is difficult as it is a diagnosis of exclusion requiring a temporal relationship between drug exposure and liver injury and a thorough work up for other causes. In addition, DILI has a very variable clinical and histologic presentation that can mimic many different etiologies of liver disease. Objective scoring systems can assess the probability that a drug caused the liver injury but liver biopsy findings are not pa...
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Taqwa Ahmed Jawad Ahmad Source Type: research
Effects of SARS-CoV-2 infection on incidence and treatment strategies of hepatocellular carcinoma in people with chronic liver disease
CONCLUSION: Although CLD patients with SARS-CoV-2 infection were not associated with increased risk of HCC, they were more likely to receive palliative treatment than those without. The detrimental effects of SARS-CoV-2 infection persisted in post-acute phase.PMID:38495273 | PMC:PMC10941734 | DOI:10.4254/wjh.v16.i2.211 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Lung-Yi Mak Matthew Shing Hin Chung Xue Li Francisco Tsz Tsun Lai Eric Yuk Fai Wan Celine Sze Ling Chui Franco Wing Tak Cheng Esther Wai Yin Chan Ching Lung Cheung Ivan Chi Ho Au Xi Xiong Wai-Kay Seto Man-Fung Yuen Carlos King Ho Wong Ian Chi Kei Wong Source Type: research
Evaluation of G3BP1 in the prognosis of acute and acute-on-chronic liver failure after the treatment of artificial liver support system
CONCLUSION: This study indicated that G3BP1 could predict the prognosis of ALF or ACLF patients treated with ALSS. The combination of G3BP1, AFP and LDH could accurately evaluate the disease condition and predict the clinical endpoint of patients.PMID:38495274 | PMC:PMC10941744 | DOI:10.4254/wjh.v16.i2.251 (Source: World Journal of Hepatology)
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Wen-Yuan Li Lu-Wen Wang Jin Dong Yao Wang Source Type: research
New markers of fibrosis in hepatitis C: A step towards the Holy Grail?
World J Hepatol. 2024 Feb 27;16(2):112-114. doi: 10.4254/wjh.v16.i2.112.ABSTRACTIn the present issue of the World Journal of Hepatology, Ferrassi et al examine the problem of liver fibrosis staging in chronic hepatitis C. They identify novel biomarkers in an effort to predict accurate fibrosis staging with the aid of the metabolome of Hepatitis C patients. Overall I think Ferrassi et al took a different approach in identifying fibrosis biomarkers, by looking at the patients' metabolome. Their biomarkers clearly separate patients from controls. They can also separate out, patients with minimal fibrosis (F0-F1 stage) and pat...
Source: World Journal of Hepatology - March 18, 2024 Category: Gastroenterology Authors: Konstantinos John Dabos Source Type: research
