Impact of Halobetasol Propionate and Tazarotene Lotion 0.01%/0.045% in the Management of Plaque Psoriasis in Adults.
Authors: Reddy V, Myers B, Yang EJ, Bhutani T Abstract Halobetasol propionate and tazarotene lotion 0.01%/0.045% (HP/TAZ) is a topical medication approved for the treatment of plaque psoriasis in adults. As a treatment modality, HP/TAZ has a combinatory therapeutic effect because it contains both a corticosteroid (HP) and a retinoid (TAZ) component. Here, we review the important clinical efficacy and safety data derived from pivotal clinical trials for HP/TAZ in the treatment of plaque psoriasis. We also discuss the mechanism of action, dosage guidelines, pharmacokinetics/pharmacodynamics, and clinical consideratio...
Source: Clinical, Cosmetic and Investigational Dermatology - July 2, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

The Correlation of Semmes-Weinstein Monofilament Test with the Level of P-75 Neurotrophin as Marker of Nerve Damage in Leprosy.
This study uses a quantitative analytic observational study approach with cross-sectional design, conducted at Kediri Leprosy Hospital, Malang, East Java, Indonesia. All leprosy patients had a clinical examination and bacterial index to classify leprosy and then the SWM test to examine the presence of neuropathy in the palms and feet. P75NTR examination uses venous blood samples. An independent t-test was used to compare the SWM and P75NTR scores based on the type of leprosy, and then the Spearman correlation test was used to determine the correlation between SWM scores and P75NTR levels. Results: In this study, SWM sc...
Source: Clinical, Cosmetic and Investigational Dermatology - July 2, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Proper Counseling and Dispensing of Isotretinoin Capsule Products by Community Pharmacists in UAE: A Simulated Patient Study.
Conclusion: Suboptimal level of the patient's assessment was revealed with poor educational counseling by the community pharmacists. New strategies are needed to improve pharmaceutical care services in the UAE. PMID: 32606878 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - July 2, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Unique Skin Metastasis from Recurrent Cancer. Case Report.
Conclusion: Skin metastasis from internal organs is rarely the first sign. In this case, skin metastasis was the only clinical sign and the only diagnostic tool to drive to the correct diagnosis of a recurrent cancer after 8 years. Dermatologists might be the first doctors to facilitate the diagnosis of skin metastasis. PMID: 32606879 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - July 2, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

IL-33/13 Axis and IL-4/31 Axis Play Distinct Roles in Inflammatory Process and Itch in Psoriasis and Atopic Dermatitis.
Conclusion: IL-31 is the key mediator for pruritus in both AD and Ps patients. IL-4/31 axis and IL-33/13 axis play distinct roles in the pathogenesis of Atopic dermatitis and Psoriasis. Interleukin serum levels were not correlated with itch and disease severity in both conditions. PMID: 32606880 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - July 2, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Vitiligo and Rise in Blood Pressure - a Case-Control Study in a Referral Dermatology Clinic in Southern Iran.
Conclusion: According to our results, vitiligo patients were more susceptible to hypertension while no association could be found between characteristics of the disease and rise in blood pressure. PMID: 32606881 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - July 2, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Ki67 and CD31 Differential Expression in Cutaneous T-Cell Lymphoma and Its Mimickers: Association with Clinicopathological Criteria and Disease Advancement.
Conclusion: There were significant differences in proliferation index and MVD between dermatoses and CTCL, and between dermatoses and all CTCL subtypes with exception of Ki67 in early mycosis fungoides (MF) and CD31 in patch lesions. Increased cell proliferation and MVD were significantly associated with older age, T3 and 4 skin involvement, significant nodes (N1-3), positive blood tumor burden (B1,2) in CTCL and TNMB stage of MF. Both markers differentiated significantly late from early MF, classic MF from its variants and non-MF CTCL from total MF, but not from late MF. In conclusion, Ki67 and CD31 expression in skin bio...
Source: Clinical, Cosmetic and Investigational Dermatology - July 2, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Comparison of UVA Protection Factor Measurement Protocols.
Conclusion: Finally, this review discussed the comparison of all in vitro and in vivo UVA-PF measurement standards and provided information in the form of texts and tables to move towards the creation of an integrated standard. Since in vitro methods of UVA-PF measurement are not reproducible due to differences in test conditions, it may be concluded that the in vivo PPD method is a more suitable option. PMID: 32547149 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 18, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Delayed Inflammatory Reactions to Hyaluronic Acid Fillers: A Literature Review and Proposed Treatment Algorithm.
Conclusion: A consensus was reached and summarized to propose a clear, easy-to-follow, stepwise algorithm for the treatment of DIRs. PMID: 32547150 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 18, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Efficacy of a Dermocosmetic Serum Combining Bakuchiol and Vanilla Tahitensis Extract to Prevent Skin Photoaging in vitro and to Improve Clinical Outcomes for Naturally Aged Skin.
Conclusion: BK+VTE combination demonstrated anti-aging efficacy and might provide a substantial benefit in the daily care of naturally aged skin in women, through their synergistic effect on inflammaging and senescence. PMID: 32494181 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 5, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Individual Burden of Psoriasis (I-BOP): Building and Validation of a New Scoring Tool for Patients with Psoriasis.
Conclusion: This tool allows for the first time to assess the burden of psoriasis patients. Its use may allow improving medical and nonmedical patient care, thus improving their daily life. PMID: 32440185 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - May 23, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Minimally Invasive Aesthetic Treatment of the Face and Neck Using Combinations of a PCL-Based Collagen Stimulator, PLLA/PLGA Suspension Sutures, and Cross-Linked Hyaluronic Acid.
Conclusion: These new guidelines provide general support to optimal management strategies. Individual treatment plans should be adapted according to the physician's individual competence and the patient's preferences. PMID: 32440186 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - May 23, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Management Patterns of Delayed Inflammatory Reactions to Hyaluronic Acid Dermal Fillers: An Online Survey in Israel.
Conclusion: The varied approach regarding the management of delayed type reactions to HA-based filler injections, reflected in our study, illustrates the existing ambivalence in the current literature regarding the management and therapy of late-onset complications. PMID: 32440187 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - May 23, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Asian Hair: A Review of Structures, Properties, and Distinctive Disorders.
This article aimed to review and summarize the characteristics and properties of Asian hair. It also aimed to discuss hair disorders including linear lupus panniculitis and pseudocyst of the scalp that occur distinctively in Asian populations. PMID: 32425573 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - May 20, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

A Novel Effect of Acyclovir on Hair Growth in BALB/c Mice: A Promising Future for Finding a New Topical Drug for the Treatment of Hirsutism.
This study aimed to investigate the potential effect of topical acyclovir on hair growth in mice. Methods: In this study, twenty-four female BALB/c mice were randomly divided into three groups in order to evaluate the hair growth-reducing effects of acyclovir (control group, vehicle group, and acyclovir group). Topical acyclovir 5% was applied on the shaved denuded skin of mice. Topical application onto the backs of the animals was performed twice daily for 28 consecutive days. The time (in days) required for hair growth initiation as well as completion of hair growth in dorsal skin of animals were recorded. On d...
Source: Clinical, Cosmetic and Investigational Dermatology - May 20, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

A Preliminary Clinical Evaluation of a Topical Product for Reducing Slight Rosacea Imperfections.
Conclusion: The moisturizing and skin barrier restoring action of Serum BK46 has been clearly proven in patients displaying mild to moderate rosacea; thus, this product is a good candidate for rosacea treatment. PMID: 32368125 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - May 6, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Epidemiology of Dermatophyte and Non-Dermatophyte Fungi Infection in Ethiopia.
Conclusion: In this study, the prevalence of dermatophytes was higher in tinea capitis 46/72 (63.8%) and T. tonsurans 29/72 (40%) was the dominant-isolated dermatophyte. Recovery of a large number of dermatophytes and non-dermatophyte fungi in our study showed that non-dermatophyte fungi are emerging as important causes of dermatophytosis warranting further intensive epidemiological studies that have public health significance are needed. PMID: 32308463 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - April 22, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

A Corrective Cosmetic Improves the Quality of Life and Skin Quality of Subjects with Facial Blemishes Caused by Skin Disorders.
Authors: Andra C, Suwalska A, Dumitrescu AM, Kerob D, Delva C, Hasse-Cieślińska M, Solymosi A, Arenbergerova M Abstract Background: Facial blemishes resulting from skin disorders have a significant effect on the patient's self-esteem and impact quality of life (QOL). Aim: To assess the impact of a corrective cosmetic (CC) on QOL on top of skin quality parameters. Methods: An international observational study was conducted on subjects with visible facial flaws that would benefit from a corrective cosmetic. Investigators collected data regarding demographics, QOL using the Skindex-16 scale, skin dryness and...
Source: Clinical, Cosmetic and Investigational Dermatology - April 15, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

A Large Cross-Sectional Survey Study of the Prevalence of Alopecia Areata in the United States.
Conclusion: This study suggests that the current AA prevalence in the US is similar to the upper estimates from the 1970s at approximately 0.21% (700,000 persons) with the current prevalence of "moderate to severe" disease at approximately 0.09% (300,000 persons). Given this prevalence and the substantial impact of AA on quality of life, the burden of AA within the US is considerable. PMID: 32280257 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - April 15, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

The Efficacy of Colloidal Oatmeal Cream 1% as Add-on Therapy in the Management of Chronic Irritant Hand Eczema: A Double-Blind Study.
This study aimed to evaluate the clinical benefit of colloidal oatmeal cream in the management of chronic irritant HE. Methods: From October 2018 to November 2019, 79 patients with diagnosis of chronic irritant HE were allocated into either intervention or control groups by block randomization method. Besides fluocinolone 0.025% ointment for the first 2 weeks of treatment period, patients in the intervention and control groups were asked to use colloidal oatmeal 1% cream or base cream for additional 4 weeks as monotherapy. Changes in the HE severity based on the hand eczema severity index (HESCI) sc...
Source: Clinical, Cosmetic and Investigational Dermatology - April 12, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Melanogenic Difference Consideration in Ethnic Skin Type: A Balance Approach Between Skin Brightening Applications and Beneficial Sun Exposure.
Authors: Markiewicz E, Idowu OC Abstract Human skin demonstrates a striking variation in tone and color that is evident among multiple demographic populations. Such characteristics are determined predominantly by the expression of the genes controlling the quantity and quality of melanin, which can alter significantly due to the presence of small nucleotide polymorphism affecting various steps of the melanogenesis process and generally linked to the lighter skin phenotypes. Genetically determined, constitutive skin color is additionally complemented by the facultative melanogenesis and tanning responses; with ...
Source: Clinical, Cosmetic and Investigational Dermatology - March 29, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Clinical Assessment of New Topical Cream Containing Two Essential Oils Combined with Tretinoin in the Treatment of Acne.
Conclusion: MOTC has shown, compared to Acnatac, to have anti-acne efficacy and to possess an anti-inflammatory activity, due to essential oils, able to reduce in vivo erythematous lesions and those induced by retinoids. PMID: 32210603 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - March 29, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Biguanides Induce Acute de novo Lipogenesis in Human Primary Sebocytes.
Discussion: These changes are consistent with an acute increase in sebocyte lipogenesis and support the potential of biguanides to cause an initial flare-up in patients suffering from severe acne. PMID: 32158247 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - March 13, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Polycaprolactone: How a Well-Known and Futuristic Polymer Has Become an Innovative Collagen-Stimulator in Esthetics.
Authors: Christen MO, Vercesi F Abstract Compared to other domains, tissue engineering and esthetics have dramatically expanded in recent years, leading to both major biomedical advances and futuristic perspectives. The two share a common approach based on biomaterials, especially polymers. This paper illustrates this with the example of polycaprolactone (PCL), a polymer synthesized in the early 1930s, and one of its most recent applications, a PCL-based collagen stimulator, a filler used in esthetics. PCL is biocompatible and biodegradable. Its specific physicochemical and mechanical properties, viscoelasticity an...
Source: Clinical, Cosmetic and Investigational Dermatology - March 13, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

A Treatment Combination of Peels, Oral Antioxidants, and Topical Therapy for Refractory Melasma: A Report of 4 Cases.
Conclusion: This protocol of trichloroacetic acid, phytic acid and ascorbic acid peel combined with an oral supplement and topical daily treatment is a viable treatment option for refractory melasma. PMID: 32161485 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - March 13, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Efficacy and Safety of Sonidegib in Adult Patients with Nevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome): Results from a Phase 2, Double-Blind, Randomized Trial.
Authors: Lear JT, Hauschild A, Stockfleth E, Squittieri N, Basset-Seguin N, Dummer R PMID: 32104037 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - February 29, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Classical Dermatomyositis: A Case Report.
Authors: Pokhrel S, Pardhe BD, Giri N, Pokhrel R, Paudel D Abstract Dermatomyositis is an idiopathic myopathy involving progressive muscle weakness with skin manifestation. Diagnosis is based upon the progressive muscle weakness, skin rashes, elevated serum muscle enzymes, muscle biopsy, and abnormal electromyogram. The incidence of dermatomyositis is rare. In this case study, we report a case of classical dermatomyositis without incidence of malignancy. Timely diagnosis and administration of steroid led to better prognosis of the patient. PMID: 32104038 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - February 29, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

One21: A Novel, Customizable Injection Protocol for Treatment of the Forehead with IncobotulinumtoxinA.
Authors: de Sanctis Pecora C Abstract It is well known that incobotulinumtoxinA (INCO) is an effective approved treatment for dynamic wrinkles of the upper face caused by the action of mimetic muscles over time. In doing so, it is important to maintain a balance between muscle groups and a natural facial appearance. Patients differ enormously in their facial anatomy regarding structure and function, both within and between genders, ethnicities, and age. Therefore, treating all patients with the same injection pattern and the same doses can result in undesired outcomes. There is a need for a tailored approach to ach...
Source: Clinical, Cosmetic and Investigational Dermatology - February 29, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Androgenetic Alopecia: Relationship to Anthropometric Indices, Blood Pressure and Life-Style Habits.
Authors: Danesh-Shakiba M, Poorolajal J, Alirezaei P Abstract Purpose: The association of androgenetic alopecia (AGA) with cardiovascular risk factors including hypertension, smoking and high body mass index (BMI) has been investigated in several studies. However, the results are discrepant. The aim of the present study was to evaluate the association of AGA with anthropometrics, blood pressure and lifestyle habits. Patients and Methods: In this case-control study, 256 men with AGA and 256 age-matched healthy controls were evaluated. Systolic and diastolic blood pressures, as well as anthropometric indices were...
Source: Clinical, Cosmetic and Investigational Dermatology - February 29, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Classification and Staging of Morgellons Disease: Lessons from Syphilis.
Conclusion: The enhanced staging system provides objective criteria to assess the severity of dermopathy in MD. Further studies are needed to determine the optimal treatment for MD based on this staging system related to Borrelia infection. PMID: 32104041 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - February 29, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Consumption of Polyphenols in Coffee and Green Tea Alleviates Skin Photoaging in Healthy Japanese Women.
Authors: Fukushima Y, Takahashi Y, Kishimoto Y, Taguchi C, Suzuki N, Yokoyama M, Kondo K Abstract Purpose: Hyperpigmentation of the skin can occur at any age depending on etiological factors but its intensity increases during adolescence in Japanese females and gradually develops further in adults. The purpose of this study was to characterize factors that influence skin hyperpigmentation, including age, skin type and dietary polyphenol sources. Patients and Methods: A cross-sectional survey of healthy Japanese women aged from 30 to 60 years (n=244) was conducted using food and environmental questionnaires and ...
Source: Clinical, Cosmetic and Investigational Dermatology - February 29, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Comparative Study of Dermatological Diseases of the Elderly in Relation to the Rest Population.
Conclusion: There are significant differences in the frequency and etiology of dermatological diseases between the two age groups. Pruritus and non-cancerous tumors of the elderly are considered to be the main findings of geriatric dermatology. PMID: 32110081 [PubMed - as supplied by publisher] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - February 29, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Conventional and Novel Treatment Modalities in Rosacea.
This article aims at redefining rosacea according to the 2017 consensus and reviewing the different treatment modalities for different manifestations of the disease in depth. PMID: 32110082 [PubMed - as supplied by publisher] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - February 29, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Newly Developed Anti-Dandruff Regimen, VB-3222, Delivers Enhanced Sensorial and Effective Therapeutic Benefits Against Moderate Adherent Dandruff.
Conclusion: The increased efficacy of VB-3222 over comparator products in vitro, and the dramatic reduction (>90%) in ASFS and pruritis in subjects within 21 days of use with excellent tolerability and sensorial profile, positions VB-3222 as the new generation treatment for adherent dandruff. Clinical Trial Registration No: CTRI/2018/05/013567. PMID: 32110083 [PubMed - as supplied by publisher] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - February 29, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Inverse Psoriasis: From Diagnosis to Current Treatment Options.
Authors: Micali G, Verzì AE, Giuffrida G, Panebianco E, Musumeci ML, Lacarrubba F Abstract Inverse psoriasis represents a clinical variant of psoriasis that is sometimes difficult to diagnose due to its clinical similarity with other skin disorders involving the folds, mainly including mechanical intertrigo, fungal and bacterial infections, contact dermatitis, seborrheic dermatitis, and lichen planus. Dermoscopy represents a useful tool for an enhanced non-invasive diagnosis. The treatment of inverse psoriasis may be challenging and include topical corticosteroids, topical calcineurin inhibitors, vitamin D a...
Source: Clinical, Cosmetic and Investigational Dermatology - February 28, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Licochalcone A in Combination with Salicylic Acid as Fluid Based and Hydroxy-Complex 10% Cream for the Treatment of Mild Acne: A Multicenter Prospective Trial.
Conclusion: Our results suggest that the daily regimen based on Licochalcone A with Salicylic acid/L-Carnitine as fluid or with Hydroxy-Complex 10% as cream represent an interesting cosmetic approach for treating mild acne. PMID: 32099436 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - February 28, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Antibacterial Activity of Passion Fruit Purple Variant (Passiflora edulis Sims var. edulis) Seeds Extract Against Propionibacterium acnes.
Authors: Jusuf NK, Putra IB, Dewi NK Abstract Background: Passion fruit is used commercially for consumption and in beverages. This plant exhibits various pharmacological properties and possesses a complex phytochemistry. In recent years, this plant has been shown to have potential antimicrobial activity. The seeds contain a high amount of piceatannol, which exhibits an inhibitory effect on Propionibacterium acnes. Therefore, the seed extract of purple variant, Passiflora edulis Sims var. edulis, may have potential antibacterial activity against P. acnes. Aim: To evaluate the antibacterial activity of P. edulis...
Source: Clinical, Cosmetic and Investigational Dermatology - February 28, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

An Open-Label Single-Arm, Monocentric Study Assessing the Efficacy and Safety of Natural Pterostilbene (Pterocarpus marsupium) for Skin Brightening and Antiaging Effects.
Conclusion: Our results suggest that natural pterostilbene is a safe and effective ingredient for use in cosmetic preparation to reduce the markers of skin ageing and brighten the skin tone. Trial Registration: Clinical Trial Registration India Identifier CTRI/2019/01/017160 [Registered on 18/01/2019]. PMID: 32099438 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - February 28, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Hyaluronan Dermal Fillers: Efforts Towards a Wider Biophysical Characterization and the Correlation of the Biophysical Parameters to the Clinical Outcome.
Authors: La Gatta A, Schiraldi C, Zaccaria G, Cassuto D Abstract Introduction: Hyaluronic Acid (HA) fillers are among the most used products in cosmetic medicine. Companies offer different formulations to allow full facial treatment and/or remodeling. Gels are being studied to establish the biophysical properties behind the specific clinical use and a correlation between the gel biophysical properties and their clinical performance. Clinicians' awareness is growing about the potential benefit deriving from such biophysical characterization. Aim: The Aliaxin® line of HA dermal fillers is the object of this s...
Source: Clinical, Cosmetic and Investigational Dermatology - February 26, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Chrysanthemum Morifolium Extract And Ascorbic Acid-2-Glucoside (AA2G) Blend Inhibits UVA-Induced Delayed Cyclobutane Pyrimidine Dimer (CPD) Production In Melanocytes.
Conclusion: The results from this study indicate that the use of natural antioxidant, Chrys in combination with AA2G, provides protection against UVA-induced delayed CPD formation by enhancing ROS scavenging activity and melanogenesis inhibition. These findings could potentially be applied for formulating post-sun exposure skin care products, possibly extending to evening-after care products. PMID: 32009811 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - February 6, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Challenges and Solutions in Oral Isotretinoin in Acne: Reflections on 35 Years of Experience.
This article provides a commentary on 4 key areas: the use of oral isotretinoin vs oral antibiotics, including the importance of early recognition of nonresponse to treatment, the psychological effects of acne and isotretinoin treatment, the side effects of isotretinoin therapy, and cosmetic treatment options that can help alleviate predictable side effects. The authors, who have all participated in various international expert groups, draw on relevant literature and their extensive professional experience with oral isotretinoin in the treatment of acne. The aim of this article is to provide an informative and practical ap...
Source: Clinical, Cosmetic and Investigational Dermatology - February 6, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Clinical and Molecular Investigation of Familial Multiple Lipomatosis: Variants in the HMGA2 Gene.
Conclusion: Variants found in exon 5 of the HMGA2 gene have not been described and have an uncertain significance in the genesis of FML. Further studies, including a more significant number of affected individuals and functional analysis of the novel variants of HGMA2 gene, should be undertaken to better understand its biological role in FML. PMID: 32021365 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - February 6, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Role of Galectin-9 in Atopic Dermatitis - Is It Mediated Through E Selectin? A Clinical and Immunohistochemical Study.
Authors: Farag AGA, Al-Sharaky DR, Allam SS, Khaled HN Abstract Background: Atopic dermatitis (AD) is a recognized T helper (Th)2, allergic, skin disease. Galectin-9 (gal-9) is a member of galectin family. It alters T-cell balance resulting in Th2 polarization. These Th2 cells yield various cytokines that may influence E selectin expression. Therefore, we hypothesized that gal-9 may have an active role in AD and this role could be mediated through E selectin. Objective: To assess this hypothesis, immunohistochemical expression of gal-9 and E selectin was investigated in skin lesions, from atopic dermatitis pati...
Source: Clinical, Cosmetic and Investigational Dermatology - February 6, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

A Triticum vulgare Extract Exhibits Regenerating Activity During the Wound Healing Process.
Conclusion: In conclusion, we demonstrated that the T. vulgare extract possessed promising potential to be developed as a wound healing promoting agent in skin care and dermatology. PMID: 32021367 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - February 6, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Does the Autophagy Related Gene 7 (ATG7) Have a Role in Non-Melanoma Skin Cancer?
Authors: Samaka RM, Basha MA, Mansour E Abstract Purpose: To evaluate the role of autophagy related gene 7 (ATG7) in non-melanoma skin cancer. Subjects and Methods: This retrospective and prospective case-control study was performed on 104 patients with non-melanoma skin cancer (NMSC) in addition to 20 apparently healthy subjects matched for age and sex as a control group. Multiple skin biopsies were taken for immunohistochemical evaluation of ATG7 expression. Results: Both epithelial and stromal ATG7 were expressed in all participants while all patients showed nucleocytoplasmic localization and controls sh...
Source: Clinical, Cosmetic and Investigational Dermatology - February 6, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

The Effect of Using Olive Oil and Fish Oil Prophylactic Dressings on Heel Pressure Injury Development in Critically Ill Patients.
Authors: Karimi Z, Mousavizadeh A, Rafiei H, Abdi N, Behnammoghadam M, Khastavaneh M, Shahini S Abstract Introduction and Aim: Prevention of pressure injuries in patients hospitalized in intensive care units is significantly important. Therefore, in the present study, the effect of using olive oil and fish oil prophylactic dressings on the development of heel pressure injuries was investigated. Methods: The present study was a clinical trial conducted in the intensive care unit of Shahid Beheshti Hospital, in Yasuj. Fifty patients, who were at moderate to high risk of pressure injuries development, were randoml...
Source: Clinical, Cosmetic and Investigational Dermatology - February 6, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Correlation Between Lipid Profile and Acne Vulgaris.
Conclusion: In conclusion, lipid profile was altered in our patients, with high cholesterol level as the commonest derangement, particularly in men. Therefore, screening for lipid profile abnormalities could be considered in the treatment of acne patients. PMID: 32021370 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - February 6, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Depression and Anxiety in Patients with Bullous Pemphigoid: Impact and Management Challenges.
The objective of this brief review is to discuss the intertwining relationship between depression and anxiety with bullous pemphigoid. PMID: 32021371 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - February 6, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Effect of Topical 5-Fluorouracil Alone versus Its Combination with Erbium:YAG (2940 nm) Laser in Treatment of Vitiligo.
Conclusion: The combination of Er:YAG with 5-FU is safe and effective in treating and improving outcome in vitiligo especially of non-resistant areas. Computer based image analysis of vitiliginous lesions and assessing post-therapy response is an easy, quick, and reliable method. PMID: 32021372 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - February 6, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

The Effectiveness of a New Topical Formulation Containing GSH-C4 and Hyaluronic Acid in Seborrheic Dermatitis: Preliminary Results of an Exploratory Pilot Study.
Discussion: The results of our pilot study confirm the efficacy and tolerability of this new topical formulation in a real-life assessment and patients showed strong adherence to therapy. These promising results - still to be confirmed on a larger number of patients - emphasize the potential SEB has in controlling the chronic inflammation of seborrheic dermatitis. PMID: 31920359 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - January 12, 2020 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research