Risk and severity of psoriasis vulgaris in relation to angiotensin II type 1 receptor gene polymorphism and metabolic syndrome.
Conclusion: Patients with psoriasis expressing the C allele of AT1R1166 are susceptible to developing metabolic syndrome and have higher PASI scores as compared with patients carrying the A allele. PMID: 31571968 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - October 2, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Erosive pustular dermatosis of the scalp: challenges and solutions.
Authors: Starace M, Alessandrini A, Baraldi C, Piraccini BM Abstract Erosive pustular dermatosis of the scalp is a rare chronic inflammatory disorder defined. It usually affects elderly people and is characterized by extensive pustular lesions, erosions, and crusts located on the scalp. The pathogenesis of this disease is not completely understood, but a known predisposing factor is skin trauma. Autoimmune disorders including rheumatoid arthritis, autoimmune hepatitis, Hashimoto thyroiditis, and Takayasu aortitis are associated diseases reported. The clinical examination reveals erythema, erosions, crusts, follicul...
Source: Clinical, Cosmetic and Investigational Dermatology - October 2, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Calcipotriol Plus Betamethasone Dipropionate Aerosol Foam For Scalp Psoriasis.
This article presents real-world experience of the effectiveness of calcipotriol (50 µg/g)/betamethasone dipropionate (0.5 mg/g) (Cal/BD) aerosol foam formulation in three cases of scalp psoriasis, and briefly reviews the literature relating to Cal/BD topical therapy in adults with scalp psoriasis. Patients had long histories of scalp psoriasis and reported negative impacts on their lives (e.g. clothing choices, psychological well-being, employment status). Previous treatments had provided inadequate or only temporary relief. Cal/BD aerosol foam relieved itching in the first few days and was associated with visible i...
Source: Clinical, Cosmetic and Investigational Dermatology - October 2, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Emollient formulations containing antiseptics reduce effectively the level of Staphylococcus aureus on skin.
Authors: Spada F, Barnes TM, Greive KA Abstract Background: Increased skin colonization by Staphylococcus aureus is associated with atopic eczema (AE) severity. Reduction of S. aureus levels on the skin results in an improvement in the clinical condition. Methods: The antimicrobial activity of topical products including a bath oil, cream, and wash combining antiseptics and emollients (A+E) was compared to products containing emollients only. The preference of patients with AE for A+E cream or emollient only cream to relieve symptoms of itching, erythema, and inflammation when applied three times daily for 10 da...
Source: Clinical, Cosmetic and Investigational Dermatology - October 1, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Autologous adipose transplantation an effective method to treat alopecia after trauma: a case report.
In this study, lipoaspiration of adipose was performed by cannula and scalp injection was done. In this case report, the authors report that scalp injection of adipose tissue has a positive effect on a patient with alopecia after trauma. The findings suggest adipose tissue can be a promising alternative method to treating men and women alopecia. PMID: 31564946 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - October 1, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Vesiculobullous diseases in relation to lupus erythematosus.
Authors: Rutnin S, Chanprapaph K Abstract Vesiculobullous lesions in lupus erythematosus (LE) are a rare cutaneous manifestation of cutaneous and/or systemic LE with variable presentation. While the minor forms of LE-associated vesiculobullous disease may cause disfigurement and discomfort, the severe forms can present with hyperacute reaction and life-threatening consequences. Specific LE and aspecific cutaneous LE are defined by the presence or absence of interface change on histopathology that can be applied to vesiculobullous diseases in relation to LE. However, the diagnosis of LE-associated vesiculobullous di...
Source: Clinical, Cosmetic and Investigational Dermatology - October 1, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Health providers induced iatrogenic delusions of infestation.
Authors: Shah PR, Cusick E, Nousari Y, Sandoz A, Tausk F Abstract Patients that suffer from factitial dermatosis mutilate their skin, often lacking any consciousness of self-injury, attributing the resulting lesions to spontaneous development. The case hereby described shows how the health providers' interventions led a patient from a baseline undiagnosed factitious disorder to frank delusions of infestation with Mycobacterium Kansasii, and a relentless search for antibiotic treatments. We highlight the need for educating health practitioners on the characteristics of psycho-cutaneous disorders. PMID: 31564948 ...
Source: Clinical, Cosmetic and Investigational Dermatology - October 1, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Facial skin revitalization with CPM ®-HA20G: an effective and safe early intervention treatment.
Conclusion: CPM®-HA20G is considered to be an effective and safe HA injectable for skin revitalization in patients suffering from signs of skin aging and loss of skin elasticity. It seems to be a perfect early intervention approach in patients that do not need volumizing treatment and a combination approach in older patients with more pronounced aging. PMID: 31496779 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - September 11, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Steroid-sparing effects and acceptability of a new skin gel containing the anti-inflammatory medicinal substance-nicotinamide.
Conclusion: This new anti-inflammatory emollient appears to be a helpful addition to the treatment armamentarium for eczema and psoriasis that may reduce reliance on topical corticosteroids and immunomodulators. PMID: 31447573 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - August 28, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Long-term objective assessments of skin rejuvenation using solar protection and solar repair shown through digital facial surface analysis and three-dimensional volumetric assessment.
Conclusion: The results of this study indicate that the solar-specific skincare formulations focused on the daily comprehensive prevention of negative solar effects and nightly repair of photodamage provide a safe and highly effective pathway to skin preservation and rejuvenation. PMID: 31447574 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - August 28, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

The regenerative potential of skin and the immune system.
Authors: Tsepkolenko A, Tsepkolenko V, Dash S, Mishra A, Bader A, Melerzanov A, Giri S Abstract Skin has the natural ability to heal and replace dead cells regulated by a network of complex immune processes. This ability is conferred by the population of resident immune cells that act in coordination with other players to provide a homeostatic environment under constant challenge. Other than providing structure and integrity, the epidermis and dermis also house distinct immune properties. The dermal part is represented by fibroblasts and endothelial cells followed by an array of immune cells which includes dendriti...
Source: Clinical, Cosmetic and Investigational Dermatology - August 16, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

A novel water-based anti-aging suncare formulation provides multifaceted protection and repair against environmental aggressors: evidence from in vitro, ex vivo, and clinical studies.
In this study, we evaluated the efficacy of an antipollution and anti-aging suncare product in in vitro, ex vivo, and clinical studies. Methods: We assessed 1) sunburn cell (SBC) and cyclobutane pyrimidine dimer (CPD) formation and gene expression profile in reconstructed human epidermis following solar irradiation, 2) malondialdehyde (MDA) level, Nrf2 immunostaining, and genetic expression in skin explants exposed to pollution, 3) carbon particle adhesion to healthy forearm skin in a clinical study, and 4) skin firmness, elasticity, and pigmentation spots in healthy women following 56 days of application. Results:...
Source: Clinical, Cosmetic and Investigational Dermatology - August 16, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Home phototherapy for patients with vitiligo: challenges and solutions.
Authors: Smith MP, Ly K, Thibodeaux Q, Bhutani T, Nakamura M Abstract Vitiligo is a chronic autoimmune condition involving selective dysfunction and destruction of melanocytes in the skin, hair, or both. The typical presentation is well-demarcated depigmented skin patches. Given vitiligo is the most common cause of depigmentation worldwide and early disease responds best to treatment, prompt diagnosis and proactive management of vitiligo are critical. While a wide variety of treatments has demonstrated variable effectiveness in treating vitiligo, phototherapy remains standard of care because of its proven efficacy ...
Source: Clinical, Cosmetic and Investigational Dermatology - August 9, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Brodalumab for the treatment of moderate-to-severe psoriasis: case series and literature review.
Authors: Pinter A, Bonnekoh B, Hadshiew IM, Zimmer S Abstract Brodalumab, a recombinant fully human monoclonal immunoglobulin IgG2 antibody with high affinity to human interleukin (IL)-17RA, is approved for the treatment of moderate-to-severe plaque psoriasis. In controlled clinical trials, brodalumab 210 mg administered by subcutaneous injection at weeks 0, 1, and 2, then 210 mg every 2 weeks, produced a rapid onset and sustained clinical response. Consistently,>80% of patients achieved PASI-75 and efficacy was maintained for>2 years. The benefits are apparent soon after the start of ther...
Source: Clinical, Cosmetic and Investigational Dermatology - August 4, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Pseudofolliculitis barbae; current treatment options.
Authors: Ogunbiyi A Abstract Pseudofolliculitis barbae (PFB) is a chronic inflammatory disorder of follicular and perifollicular skin characterized by papules, pustules, and post-inflammatory hyperpigmentation. It occurs more frequently in men of African and Asian descent. The etiology of PFB is multifactorial. Shaving or plucking the hair precipitates the onset of an inflammatory reaction that results from the penetration of the adjacent skin by the growing sharp tips. The curved shape of the hair follicle allows for the downward curvature and penetration of the growing hair tips into the skin. The onset of the fo...
Source: Clinical, Cosmetic and Investigational Dermatology - July 30, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Evaluation of the safety and efficacy of a triple combination cream (hydroquinone, tretinoin, and fluocinolone) for treatment of melasma in Middle Eastern skin.
Conclusion: The triple combination formula was reasonably safe and effective for treatment of melasma in Middle Eastern patients. PMID: 31354327 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - July 30, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Association between heterozygote Val92Met MC1R gene polymorphisms with incidence of melasma: a study of Javanese women population in Yogyakarta.
Conclusion: The findings showed Val92Met genotypes, sun exposure and family history were risk factors for melasma incidence. This is the first study on incidence of melasma in an Indonesian population and contributes to ongoing efforts to understand the mechanisms of melasma. PMID: 31308719 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - July 17, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Immunohistochemical study of janus kinase 1/signal transducer and activator of transcription 3 in psoriasis vulgaris.
Authors: Farag AGA, Samaka R, Elshafey EN, Shehata WA, El Sherbiny EG, Hammam MA Abstract Background: Human JAKs are responsible for generating docking sites for human SSTAT phosphorylation. The role of JAKs in psoriasis pathogenesis has not been clearly explained. Aim: To investigate the role of JAK1 in psoriasis pathogenesis and to assess if this role is mediated through STAT3 or not, through evaluation of their immunohistochemical expression in the skin of psoriatic patients. Methods: This case-control study was carried out on 26 patients presenting with psoriasis vulgaris versus 26 age- and sex-matched apparent...
Source: Clinical, Cosmetic and Investigational Dermatology - July 17, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Outdoor testing of the photoprotection provided by a new water-based broad-spectrum SPF50+ sunscreen product: two double-blind, split-face, randomized controlled studies in healthy adults.
Conclusion: These outdoor studies confirm the efficacy of this new SPF50+ water-based sunscreen in conditions that closer represent real-life sun exposure. PMID: 31303776 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - July 16, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Role of Janus kinase 1 and signal transducer and activator of transcription 3 in vitiligo.
Authors: Samaka RM, Basha MA, Menesy D Abstract Background: Vitiligo is an acquired autoimmune skin disorder. The often-visible lesions of vitiligo have a major impact on patients' quality of life and the results of the treatment regimens on offer are unsatisfactory, so there is a need for new therapeutic regimens. Recent advances in vitiligo pathogenesis have led to recognition of the importance of the JAK-STAT pathway as an attractive therapeutic option. Purpose: To evaluate role of JAK1 and STAT3 in vitiligo. Methods: This prospective case-control study was carried out on 35 patients presenting with viti...
Source: Clinical, Cosmetic and Investigational Dermatology - July 16, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Dairy consumption and acne: a case control study in Kabul, Afghanistan.
Conclusion: This study showed an association between high intakes of dairy products and acne in adolescence suggesting that dairy intake may be a factor contributing to acne. PMID: 31303778 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - July 16, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Hearing status in patients with vitiligo.
Conclusion: Vitiligo patients have normal hearing status. PMID: 31296994 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - July 13, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Molluscum contagiosum: an update and review of new perspectives in etiology, diagnosis, and treatment.
The objective of this article is to review the current evidence in etiology, clinical manifestations, diagnosis, and management alternatives of MC. PMID: 31239742 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 27, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract.
Authors: Waranuch N, Phimnuan P, Yakaew S, Nakyai W, Grandmottet F, Onlom C, Srivilai J, Viyoch J Abstract Objective: We compared the efficacy of an antiacne hydrogel formulated with a combination of Aloe barbadensis leaf extract, Garcinia mangostana peel extract, and Camellia sinensis leaf extract (AGC) at a ratio of 50:25:1 with a marketed 1% clindamycin gel (CG) formulation on antiacne and antiblotch activities. Methods: A single-center, parallel-arm, randomized controlled trial was performed from November 2017 to April 2018. Sixty subjects with mild-moderate acne severity according to the the American Academy o...
Source: Clinical, Cosmetic and Investigational Dermatology - June 27, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Is dermoscopy a good tool for the diagnosis of lentigo maligna and lentigo maligna melanoma? A meta-analysis.
Conclusion: These findings suggest that dermoscopy has good accuracy in the diagnosis of LM/LMM. PMID: 31239744 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 27, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Use of formulations for sensitive skin improves the visible signs of aging, including wrinkle size and elasticity.
This study investigates the antiaging effects of a skin care system developed for use on sensitive skin. Methods: A total of 30 healthy Caucasian females, aged 32-72, were enrolled in this double-blind randomized placebo-controlled split-face study. A routine consisting of twice daily topical applications of the test cleanser and test moisturizer or placebo or positive control products was followed for 28 days, with parameters measured at baseline and at 7-day intervals. Objective skin assessments for hydration, transepidermal water loss (TEWL), skin surface topography, elasticity and safety assessment were conducted. Resu...
Source: Clinical, Cosmetic and Investigational Dermatology - June 27, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Clinical utility of daylight photodynamic therapy in the treatment of actinic keratosis - a review of the literature.
Authors: Nguyen M, Sandhu SS, Sivamani RK Abstract Actinic keratosis (AK) is an early in situ squamous cell carcinoma that results from UV light exposure and has the potential to evolve into invasive tumor. Therefore, it is crucial that AKs are monitored and treated appropriately. Photodynamic therapy (PDT) is a treatment option that is minimally invasive and leaves patients with cosmetically superior results. However, disadvantages of PDT include pain and lengthy clinic visits. Accordingly, there has been much interest in the use of daylight photodynamic therapy (daylight-PDT) as a more convenient and less painful...
Source: Clinical, Cosmetic and Investigational Dermatology - June 27, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Skin protective effects of an antipollution, antioxidant serum containing Deschampsia antartica extract, ferulic acid and vitamin C: a controlled single-blind, prospective trial in women living in urbanized, high air pollution area.
The objectives of the study were to evaluate the effects of treatment on skin barrier function, assessed by transepidermal water loss (TEWL) measurement (Tewameter), the effect on dark spots, evaluated by means of colorimetry (Colorimeter CL 400), and the effect on squalene peroxide (SQOOH)/squalene (SQ) skin ratio assessed with face swabs. Results: The trial was conducted between November 20 and December 19, 2018. In comparison with baseline, the product induced a significant improvement of skin hydration (-19% of TEWL), a significant improvement of dark spots (+7%) and a significant improvement of SQOOH/SQ ratio (-16%). ...
Source: Clinical, Cosmetic and Investigational Dermatology - June 20, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Painful tumors of the skin: "CALM HOG FLED PEN AND GETS BACK" [Corrigendum].
Painful tumors of the skin: "CALM HOG FLED PEN AND GETS BACK" [Corrigendum]. Clin Cosmet Investig Dermatol. 2019;12:401 Authors: PMID: 31213871 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 20, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Effects of a cream containing 5% hyaluronic acid mixed with a bacterial-wall-derived glycoprotein, glycyrretinic acid, piroctone olamine and climbazole on signs, symptoms and skin bacterial microbiota in subjects with seborrheic dermatitis of the face.
Conclusion: Treatment with EDS applied twice daily for 6 consecutive weeks was associated with a reduction of the signs and symptoms of SD. Furthermore, after EDS cream treatment, a reequilibrating effect on facial skin microbiota was observed. The product was very well tolerated. PMID: 31190937 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 15, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Keloid treatment: what about adjuvant radiotherapy?
Conclusion: Surgical excision combined with immediate PORT is an effective and easy treatment with good esthetic results and an acceptable recurrence rate. It should be considered for patients with persistent keloid formation after failure of other treatments and those at high risk of relapse. PMID: 31190938 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 15, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Protective effects of glycerol and xylitol in keratinocytes exposed to hyperosmotic stress.
Conclusions: Glycerol and xylitol protect keratinocytes against osmotic stress. Despite their similar chemical structure, the effect of these polyols displayed differences. Hence, joint application of glycerol and xylitol may be a useful therapeutic approach for different skin disorders. PMID: 31190939 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 15, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Epidermolytic hyperkeratosis: clinical update.
This article reviews subtypes of ichthyosis, with a focus on EHK, genetics behind the disease, recently reported mutations, the existing diagnostics and treatments for the same and potential of new modalities in diagnosis/treatment. PMID: 31190940 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 15, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Treatment-resistant prurigo nodularis.
Authors: Kolli SS, Haidari W, Feldman SR PMID: 31190941 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 15, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Impact of olive oil and honey on healing of diabetic foot: a randomized controlled trial.
Conclusion: The results of this study reveal that honey is as effective as olive oil in the treatment of diabetic foot. Given the few studies on this topic, further investigation is needed. PMID: 31190942 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 15, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Efficacy and tolerability of a biomineral formulation for treatment of onychoschizia: a randomized trial.
Authors: Sparavigna A, Tenconi B, La Penna L Abstract Purpose: Onychoschizia causes lamellar splitting of the nail plate. It is a common problem seen by dermatologists therefore, an effective treatment is needed. The aim of this study was to evaluate the efficacy and tolerability of a biomineral formulation (Biomineral Unghie) applied topically, and/or as an oral supplement, in subjects with onychoschizia. Patients and methods: This single center, randomized, parallel-group, open-label study was conducted between March 2017 and June 2017. Fifty non-menopausal females aged 18 years or over with onychoschizia we...
Source: Clinical, Cosmetic and Investigational Dermatology - June 15, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Clinical evidence on the efficacy and tolerability of a topical medical device containing benzoylperoxide 4%, retinol 0.5%, mandelic acid 1% and lactobionic acid 1% in the treatment of mild facial acne: an open label pilot study.
Conclusion: The topical medical device has shown to be clinically effective and well tolerated for the treatment of mild acne. Side effects were mild, transient and well tolerated. The results of our study demonstrated a high tolerability of this new combination of benzoylperoxide 4% and retinol. Furthermore, our results suggested that the studied compound could be considered as a "maintenance treatment" after specific pharmacological treatment, even in more severe types of acne. PMID: 31190944 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 15, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Distinguishing truly recalcitrant prurigo nodularis from poor treatment adherence: a response to treatment-resistant prurigo nodularis [Response to letter].
Authors: Kowalski EH, Kneiber D, Valdebran M, Patel U, Amber KT PMID: 31190945 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - June 15, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Occasional acne; an acne variant.
This article is about a common skin eruption that dermatologists face regularly in their clinics. It is a form of acne that patients frequently refer to as nightshifts acne, stress acne or airplane acne (after experiencing a prior occasion that might aggravate it). Physical or psychological stress is not the only causative factor, therefore we took into consideration of naming it based on its presentation irrespectively of the skin proneness to acne and self-limiting tendency, we name the entity as "occasional acne". This article will discuss the similarities and differences between this entity and other forms of...
Source: Clinical, Cosmetic and Investigational Dermatology - May 24, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Botulinum toxin (Botox) A for reducing the appearance of facial wrinkles: a literature review of clinical use and pharmacological aspect.
Conclusion: Botox is good and safe medicine to reduce the appearance of facial wrinkles. PMID: 31114283 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - May 24, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

A unique gel matrix moisturizer delivers deep hydration resulting in significant clinical improvement in radiance and texture.
Conclusion: These studies demonstrated that the gel matrix formula increased skin water content in deeper layers, and resulted in significant clinical improvements in hydration, barrier function, and clinical appearance of radiance. PMID: 31114284 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - May 24, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Fine needle aspiration cytology as a preliminary diagnostic tool in chondroid syringoma: a case report and review.
We report a case of chondroid syringoma (CS) in a 44-year-old male. He presented with a firm asymptomatic nodule in his left upper lip of 2-year duration. The initial clue to the diagnosis was made on fine needle aspiration cytology (FNAC), and a final diagnosis was based on histopathological examination. The case highlights the importance of FNAC in providing clues to the diagnosis of suspected cases of chondroid syringoma before performing large excisions and repair, which would require more skill and time. We have also reviewed the cytological findings of all the cases of benign CS reported until the current date. P...
Source: Clinical, Cosmetic and Investigational Dermatology - May 24, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Clinical utility of secukinumab in moderate-to-severe scalp psoriasis: evidence to date.
Authors: Kivelevitch D, Amin S, Menter A Abstract Psoriasis is an immune-mediated inflammatory dermatosis commonly affecting the scalp and fringes of the face, neck and ears. It may be difficult to treat and the presence of extensive and highly visible lesions may significantly influence psychosocial well-being. Secukinumab, a monoclonal antibody that selectively targets interleukin-17A and has been shown to provide robust and sustained efficacy for whole body psoriasis. In this review, we evaluate the evidence to date of secukinumab in patients with moderate-to-severe scalp psoriasis. A comprehensive Cochrane data...
Source: Clinical, Cosmetic and Investigational Dermatology - May 24, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Role of insulin-like growth factor-1 in skin tags: a clinical, genetic and immunohistochemical study in a sample of Egyptian patients.
Authors: Farag AGA, Abdu Allah AMK, El-Rebey HS, Mohamed Ibraheem KI, Mohamed ASED, Labeeb AZ, Elgazzar AE, Haggag MM Abstract Background: Skin tags (STs) are benign connective tissue neoplasms, in which insulin-like growth factor -1 (IGF-1) has a mitogenic and antiapoptotic activity. Purpose: We aimed to study for the first time, the possible role of IGF-1 (CA) 19 and rs6214 gene polymorphisms, and its tissue immunoreactivity in the pathogenesis of STs. Patients and methods: This case-control study included 40 ST patients and 20 controls. We searched for (CA) 19 single-nucleotide polymorphism (SNP) using conversio...
Source: Clinical, Cosmetic and Investigational Dermatology - May 24, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Comparison of efficacy and safety of atorvastatin 5% lotion and betamethasone 0.1% lotion in the treatment of scalp seborrheic dermatitis.
Conclusion: Although preliminary, the results of the present study showed that topical atorvastatin has a comparable effect to topical betamethasone and can be considered as an alternative therapeutic modality in the treatment of scalp SD. However, these results need to be confirmed in future studies while taking into consideration the improvement of topical statin formulations. PMID: 31118730 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - May 24, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Delayed hypersensitivity reaction to hyaluronic acid dermal filler following influenza-like illness.
Conclusion: Although there is a low risk of late onset adverse reaction with hyaluronic acid fillers, injecting physicians must be aware of the possible filler reaction following the influenza infection. PMID: 31118731 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - May 24, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Dermoscopic pattern of pityriasis versicolor.
Conclusion: To our knowledge, this is the first study describing the dermoscopic features of PV in such a large number of patients. Description of these new features adds valuable information and may help to establish dermoscopy as an important auxiliary tool for the diagnosis of PV. PMID: 31118732 [PubMed] (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - May 24, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Spotlight on brodalumab in the treatment of plaque psoriasis: the evidence to date.
This article discusses the mechanism of action and the efficacy and safety profile of brodalumab presented in the literature. Brodalumab, the latest approved anti-IL-17-class medication, is the only one that exerts its effects on IL-17C as well as on IL-17A and IL-17F, blocking the shared IL-17 receptor A. In this sense, considering the recent evidence, brodalumab could have beneficial effects not only on psoriasis, but also on atopic dermatitis. It could also serve as a therapeutic alternative in patients who develop paradoxical eczematous reactions or atopic-like dermatitis during treatment with other anti-IL-17A (secuki...
Source: Clinical, Cosmetic and Investigational Dermatology - May 24, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

Treatment-resistant atopic dermatitis: challenges and solutions.
Authors: Johnson BB, Franco AI, Beck LA, Prezzano JC Abstract Atopic dermatitis (AD) is a common, chronic, relapsing-remitting inflammatory disease that can be challenging to treat. Patients with mild disease are usually managed well with good skin care practices including moisturization and appropriate bathing along with intermittent use of topical therapies such as topical corticosteroids and/or topical calcineurin inhibitors during flares. Patients with frequent flares may benefit from proactive application of topical therapies twice a week to the most troublesome areas. Patients with severe disease often presen...
Source: Clinical, Cosmetic and Investigational Dermatology - April 10, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research

A series of in vitro and human studies of a novel lip cream formulation for protecting against environmental triggers of recurrent herpes labialis.
Authors: Gfeller CF, Wanser R, Mahalingam H, Moore DJ, Wang X, Lin CB, Shanga G, Grove G, Rawlings AV Abstract Purpose: These studies describe the testing of a novel, daily-use lip cream designed for individuals with lips prone to recurrent herpes labialis (RHL) that protects against environmental triggers. Subjects and methods: In vitro occlusive and in vitro and in vivo photoprotection analyses, a characterization of normal vs dry lips, and a randomized, evaluator-blinded, clinical trial that assessed the lip cream in healthy subjects with dry lips were conducted. In the clinical trial, subjects applied the l...
Source: Clinical, Cosmetic and Investigational Dermatology - April 10, 2019 Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research