A new GLP1, GIP and glucagon receptor triagonist
Nature Reviews Endocrinology, Published online: 06 January 2022; doi:10.1038/s41574-021-00631-wA new GLP1, GIP and glucagon receptor triagonist (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 6, 2022 Category: Endocrinology Authors: Shimona Starling Source Type: research

Effects of a tax on sugar-sweetened beverages
Nature Reviews Endocrinology, Published online: 06 January 2022; doi:10.1038/s41574-021-00633-8Effects of a tax on sugar-sweetened beverages (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 6, 2022 Category: Endocrinology Authors: Shimona Starling Source Type: research

SRC2 controls the refeeding response in mice
Nature Reviews Endocrinology, Published online: 06 January 2022; doi:10.1038/s41574-021-00630-xSRC2 controls the refeeding response in mice (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 6, 2022 Category: Endocrinology Authors: Olivia Tysoe Source Type: research

Osteocalcin influences lifelong adrenal function
Nature Reviews Endocrinology, Published online: 06 January 2022; doi:10.1038/s41574-021-00632-9Osteocalcin influences lifelong adrenal function (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 6, 2022 Category: Endocrinology Authors: Shimona Starling Source Type: research

Type 2 diabetes mellitus in sub-Saharan Africa: challenges and opportunities
Nature Reviews Endocrinology, Published online: 04 January 2022; doi:10.1038/s41574-021-00613-yThis Review outlines the burden of type 2 diabetes mellitus and its complications in sub-Saharan Africa, including the pathogenesis, standards of care for treatment and preventive strategies. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 4, 2022 Category: Endocrinology Authors: Ayesha A. Motala Jean Claude Mbanya Kaushik Ramaiya Fraser J. Pirie Kenneth Ekoru Source Type: research

Assessment and treatment of thyroid disorders in pregnancy and the postpartum period
Nature Reviews Endocrinology, Published online: 04 January 2022; doi:10.1038/s41574-021-00604-zThyroid hormone is important during pregnancy, as it facilitates appropriate fetal development. Furthermore, thyroid dysfunction during pregnancy can negatively affect obstetric outcomes and maternal health. This Review discusses the evaluation and management of thyroid disorders in pregnancy and in the postpartum period. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 4, 2022 Category: Endocrinology Authors: Sun Y. Lee Elizabeth N. Pearce Source Type: research

Delving into the effects of time-restricted feeding
Nature Reviews Endocrinology, Published online: 23 December 2021; doi:10.1038/s41574-021-00628-5Delving into the effects of time-restricted feeding (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 23, 2021 Category: Endocrinology Authors: Claire Greenhill Source Type: research

We demand a seat at the table
Nature Reviews Endocrinology, Published online: 21 December 2021; doi:10.1038/s41574-021-00623-wWe demand a seat at the table. The leadership table. The funding table. The NIH study section table. The high impact authorship table. All are places we deserve to be, yet you don’t find many faces like mine in places like these. You certainly don’t find many experiences like mine. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 21, 2021 Category: Endocrinology Authors: Stanley Andrisse Source Type: research

Exercise-induced plasma factors confer brain benefits
Nature Reviews Endocrinology, Published online: 20 December 2021; doi:10.1038/s41574-021-00624-9Exercise-induced plasma factors confer brain benefits (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 20, 2021 Category: Endocrinology Authors: Shimona Starling Source Type: research

Adipocyte-derived exosomes drive cancer metastasis
Nature Reviews Endocrinology, Published online: 16 December 2021; doi:10.1038/s41574-021-00622-xAdipocyte-derived exosomes drive cancer metastasis (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 16, 2021 Category: Endocrinology Authors: Olivia Tysoe Source Type: research

Environmental factors in declining human fertility
This article discusses trends in human reproductive behaviour and health that are associated with infertility. These changes have occurred over a period of only a couple of generations, so environmental factors are suggested to have a role. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 15, 2021 Category: Endocrinology Authors: Niels E. Skakkeb æk Rune Lindahl-Jacobsen Hagai Levine Anna-Maria Andersson Niels J ørgensen Katharina M. Main Øjvind Lidegaard L ærke Priskorn Stine A. Holmboe Elvira V. Br äuner Kristian Almstrup Luiz R. Franca Ariana Znaor Andreas Kortenkamp Roger Source Type: research

Paracetamol use in pregnancy — caution over causal inference from available data
Nature Reviews Endocrinology, Published online: 14 December 2021; doi:10.1038/s41574-021-00606-xParacetamol use in pregnancy — caution over causal inference from available data (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 14, 2021 Category: Endocrinology Authors: Sura Alwan Elizabeth A. Conover Lorrie Harris-Sagaribay Steven H. Lamm Sharon V. Lavigne Shari I. Lusskin Sarah G. Obican Alfred N. Romeo Anthony R. Scialli Katherine L. Wisner Source Type: research

Reply to ‘Paracetamol use in pregnancy — caution over causal inference from available data’; ‘Handle with care — interpretation, synthesis and dissemination of data on paracetamol in pregnancy’
Nature Reviews Endocrinology, Published online: 14 December 2021; doi:10.1038/s41574-021-00610-1Reply to ‘Paracetamol use in pregnancy — caution over causal inference from available data’; ‘Handle with care — interpretation, synthesis and dissemination of data on paracetamol in pregnancy’ (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 14, 2021 Category: Endocrinology Authors: Ann Z. Bauer Shanna H. Swan David Kriebel Zeyan Liew Hugh S. Taylor Carl-Gustaf Bornehag Anderson M. Andrade J ørn Olsen Rigmor H. Jensen Rod T. Mitchell Niels E. Skakkebaek David M. Kristensen Source Type: research

Handle with care — interpretation, synthesis and dissemination of data on paracetamol in pregnancy
Nature Reviews Endocrinology, Published online: 14 December 2021; doi:10.1038/s41574-021-00605-yHandle with care — interpretation, synthesis and dissemination of data on paracetamol in pregnancy (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 14, 2021 Category: Endocrinology Authors: Per Damkier Brian Cleary Corinna Weber-Schoendorfer Svetlana Shechtman Matteo Cassina Alice Panchaud Orna Diav-Cirtin Source Type: research

Taking a closer look at metabolically healthy obesity
Nature Reviews Endocrinology, Published online: 14 December 2021; doi:10.1038/s41574-021-00619-6Whether or not there is a form of healthy obesity remains controversial. Contemporary imaging techniques might help answer this question. It is proposed that low levels of visceral adipose tissue and ectopic adipose tissue combined with a preferential accumulation of gluteal and femoral adipose tissue might define a ‘super healthy obesity’ phenotype. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 14, 2021 Category: Endocrinology Authors: Jean-Pierre Despr és Source Type: research

New insights into β-cell failure, regeneration and replacement
Nature Reviews Endocrinology, Published online: 10 December 2021; doi:10.1038/s41574-021-00611-0In 2021, several discoveries shed light on the pathomechanisms of β-cell failure during the initiation and progression of diabetes mellitus, and validated novel molecular targets for intervention. Moreover, the field of stem-cell-derived replacements for β-cells is rapidly advancing. These advances bring us closer to therapies to protect and/or regenerate β-cell mass. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 10, 2021 Category: Endocrinology Authors: Mostafa Bakhti Heiko Lickert Source Type: research

Stem-cell derived pancreatic endoderm cells in the treatment of T1DM
Nature Reviews Endocrinology, Published online: 10 December 2021; doi:10.1038/s41574-021-00620-zStem-cell derived pancreatic endoderm cells in the treatment of T1DM (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 10, 2021 Category: Endocrinology Authors: Claire Greenhill Source Type: research

Logic and mechanisms of metabolite signalling
Nature Reviews Endocrinology, Published online: 10 December 2021; doi:10.1038/s41574-021-00618-7Metabolites have emerged as central regulators of biological function, but understanding mechanisms of metabolite regulation has proven challenging. In 2021 we have seen discoveries in the field of metabolite signalling motivated by a combination of scientific intuition and the elegant deployment of new technologies. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 10, 2021 Category: Endocrinology Authors: Edward T. Chouchani Source Type: research

Statins and diabetes mellitus progression: a fly in the ointment?
Nature Reviews Endocrinology, Published online: 10 December 2021; doi:10.1038/s41574-021-00612-zStatins might exert diabetogenic effects, potentially increasing insulin resistance and worsening glucose control. However, patients with diabetes mellitus are at high or very high cardiovascular risk and, thus, statin use is strongly recommended. Adding ezetimibe to statins might be helpful in achieving lipid targets and reducing cardiovascular risk without adversely affecting glucose metabolism. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 10, 2021 Category: Endocrinology Authors: Niki Katsiki Dimitri P. Mikhailidis Source Type: research

Molecular transducers and the cardiometabolic benefits of exercise
Nature Reviews Endocrinology, Published online: 08 December 2021; doi:10.1038/s41574-021-00609-8Physical activity stimulates tissue crosstalk and provides powerful protection against cardiometabolic disease. This past year, several studies have expanded our knowledge of the secreted molecules regulated by physical activity, uncovered new circuits of cell and tissue crosstalk and provided fundamental insights into the mechanisms that underlie the cardiometabolic benefits of exercise. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 8, 2021 Category: Endocrinology Authors: Jonathan Z. Long Source Type: research

Exploring the regulation of glucagon secretion
Nature Reviews Endocrinology, Published online: 08 December 2021; doi:10.1038/s41574-021-00617-8Exploring the regulation of glucagon secretion (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 8, 2021 Category: Endocrinology Authors: Shimona Starling Source Type: research

Metabolic disorders, COVID-19 and vaccine-breakthrough infections
Nature Reviews Endocrinology, Published online: 06 December 2021; doi:10.1038/s41574-021-00608-9Obesity and impaired metabolic health are important risk factors for severe COVID-19. Novel data indicate that these risk factors might also promote vaccine-breakthrough SARS-CoV-2 infections in fully vaccinated people. Here, these relationships are discussed and post-acute sequelae of COVID-19 that are related to obesity and impaired metabolic health are addressed. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 6, 2021 Category: Endocrinology Authors: Norbert Stefan Source Type: research

The emerging role of incretins and twincretins
Nature Reviews Endocrinology, Published online: 06 December 2021; doi:10.1038/s41574-021-00607-wIn 2021, clinical trials reported the promising effects of incretins and a new class of dual glucagon-like peptide 1–glucose-dependent insulinotropic peptide receptor agonists in preventing and treating type 2 diabetes mellitus and obesity. These ‘twincretins’ will transform the prevention of obesity and type 2 diabetes mellitus and the care of people with these conditions. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - December 6, 2021 Category: Endocrinology Authors: Elaine Chow Juliana C. N. Chan Source Type: research

Follistatin linked to type 2 diabetes mellitus risk
Nature Reviews Endocrinology, Published online: 30 November 2021; doi:10.1038/s41574-021-00615-wFollistatin linked to type 2 diabetes mellitus risk (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 30, 2021 Category: Endocrinology Authors: Olivia Tysoe Source Type: research

DDIT4 contributes to macrophage reprogramming
Nature Reviews Endocrinology, Published online: 30 November 2021; doi:10.1038/s41574-021-00614-xDDIT4 contributes to macrophage reprogramming (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 30, 2021 Category: Endocrinology Authors: Olivia Tysoe Source Type: research

SNPs influence obesity and puberty timing
Nature Reviews Endocrinology, Published online: 30 November 2021; doi:10.1038/s41574-021-00616-9SNPs influence obesity and puberty timing (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 30, 2021 Category: Endocrinology Authors: Olivia Tysoe Source Type: research

International Consensus Statement on the diagnosis, multidisciplinary management and lifelong care of individuals with achondroplasia
Nature Reviews Endocrinology, Published online: 26 November 2021; doi:10.1038/s41574-021-00595-xAchondroplasia is the most common skeletal dysplasia and is characterized by various lifelong clinical, functional and psychosocial challenges for affected individuals. This first International Consensus Statement on the care of children and adults with achondroplasia aims to facilitate the global standardization and improvement of achondroplasia clinical care. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 26, 2021 Category: Endocrinology Authors: Ravi Savarirayan Penny Ireland Melita Irving Dominic Thompson In ês Alves Wagner A. R. Baratela James Betts Michael B. Bober Silvio Boero Jenna Briddell Jeffrey Campbell Philippe M. Campeau Patricia Carl-Innig Moira S. Cheung Martyn Cobourne Val érie Co Source Type: research

Research in metabolic ageing — a tale of mice versus humans?
Nature Reviews Endocrinology, Published online: 25 November 2021; doi:10.1038/s41574-021-00597-9The investigation of age-induced disease progression in humans is time consuming and resource intensive. One burning question for the exploration of human metabolic ageing is how similar metabolic changes over a lifetime are between humans and mice. A recent study highlights similarities and disparities between these species throughout their lifespan. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 25, 2021 Category: Endocrinology Authors: Susanna M. Hofmann R üdiger Landgraf Source Type: research

Time-restricted feeding and circadian autophagy for long life
Nature Reviews Endocrinology, Published online: 24 November 2021; doi:10.1038/s41574-021-00600-3Time-restricted feeding (TRF) has shown many health benefits in different organisms, but its effect on lifespan is unknown. A new study showed that a novel intermittent TRF (iTRF) dietary regimen can extend the healthy lifespan of Drosophila. A clock-dependent nightly rise in autophagy drives the lifespan benefits of iTRF. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 24, 2021 Category: Endocrinology Authors: Hong Long Satchidananda Panda Source Type: research

Highlights from SfE BES 2021
Nature Reviews Endocrinology, Published online: 24 November 2021; doi:10.1038/s41574-021-00603-0Highlights from SfE BES 2021 (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 24, 2021 Category: Endocrinology Authors: Shimona Starling Source Type: research

MC3R controls growth and puberty onset
Nature Reviews Endocrinology, Published online: 24 November 2021; doi:10.1038/s41574-021-00602-1MC3R controls growth and puberty onset (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 24, 2021 Category: Endocrinology Authors: Olivia Tysoe Source Type: research

Non-invasive methods for imaging hepatic steatosis and their clinical importance in NAFLD
Nature Reviews Endocrinology, Published online: 23 November 2021; doi:10.1038/s41574-021-00584-0Imaging modalities are now available that enable non-invasive quantitative measurements of liver fat content. This Review highlights the various modalities and their use in clinical trials, discusses the clinical importance of hepatic steatosis for progression of nonalcoholic fatty liver disease and proposes how the new modalities might be used going forward. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 23, 2021 Category: Endocrinology Authors: Nobuharu Tamaki Veeral Ajmera Rohit Loomba Source Type: research

The health effects of vitamin D supplementation: evidence from human studies
Nature Reviews Endocrinology, Published online: 23 November 2021; doi:10.1038/s41574-021-00593-zThis Review highlights results from large randomized clinical trials performed during the period 2017–2020 and Mendelian randomization studies on vitamin D levels. Together, findings indicate that vitamin D supplementation alone in vitamin D-replete adults does not provide health benefits; however, vitamin D deficiency should always be corrected. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 23, 2021 Category: Endocrinology Authors: Roger Bouillon Despoina Manousaki Cliff Rosen Katerina Trajanoska Fernando Rivadeneira J. Brent Richards Source Type: research

The manifold roles of protein S-nitrosylation in the life of insulin
Nature Reviews Endocrinology, Published online: 17 November 2021; doi:10.1038/s41574-021-00583-1S-nitrosylation is a key molecular mechanism in the regulation of insulin signalling. This Review explores the role of S-nitrosylation throughout the life cycle of insulin, in both metabolic health and disease. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 17, 2021 Category: Endocrinology Authors: Hua-Lin Zhou Richard T. Premont Jonathan S. Stamler Source Type: research

FAPs linked with muscle degeneration in T2DM
Nature Reviews Endocrinology, Published online: 16 November 2021; doi:10.1038/s41574-021-00601-2FAPs linked with muscle degeneration in T2DM (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 16, 2021 Category: Endocrinology Authors: Shimona Starling Source Type: research

Glycogen involved in browning of adipocytes
Nature Reviews Endocrinology, Published online: 10 November 2021; doi:10.1038/s41574-021-00599-7Glycogen involved in browning of adipocytes (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 10, 2021 Category: Endocrinology Authors: Claire Greenhill Source Type: research

Cause of rare form of Cushing syndrome found
Nature Reviews Endocrinology, Published online: 10 November 2021; doi:10.1038/s41574-021-00596-wCause of rare form of Cushing syndrome found (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 10, 2021 Category: Endocrinology Authors: Olivia Tysoe Source Type: research

Glycogen involved in browning of adipocytes
Nature Reviews Endocrinology, Published online: 10 November 2021; doi:10.1038/s41574-021-00599-7Glycogen involved in browning of adipocytes (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 10, 2021 Category: Endocrinology Authors: Claire Greenhill Source Type: research

Cause of rare form of Cushing syndrome found
Nature Reviews Endocrinology, Published online: 10 November 2021; doi:10.1038/s41574-021-00596-wCause of rare form of Cushing syndrome found (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 10, 2021 Category: Endocrinology Authors: Olivia Tysoe Source Type: research

Machine intelligence in non-invasive endocrine cancer diagnostics
Nature Reviews Endocrinology, Published online: 09 November 2021; doi:10.1038/s41574-021-00543-9This Review explains core concepts in artificial intelligence (AI) and machine learning for endocrinologists. AI applications in endocrine cancer diagnostics are highlighted as well as research challenges and future directions for the field. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 9, 2021 Category: Endocrinology Authors: Nicole M. Thomasian Ihab R. Kamel Harrison X. Bai Source Type: research

More evidence of the benefits of fasting
Nature Reviews Endocrinology, Published online: 04 November 2021; doi:10.1038/s41574-021-00594-yMore evidence of the benefits of fasting (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - November 4, 2021 Category: Endocrinology Authors: Shimona Starling Source Type: research

Adaptive immune cells shape obesity-associated type 2 diabetes mellitus and less prominent comorbidities
Nature Reviews Endocrinology, Published online: 26 October 2021; doi:10.1038/s41574-021-00575-1This Review summarizes adaptive immune cell dysregulation in obesity and type 2 diabetes mellitus (T2DM). Under-appreciated comorbidities of obesity and T2DM (oral cavity inflammation, neuroinflammation and dysbiosis) are considered, and previous clinical trials of anti-inflammatory therapies for T2DM are discussed. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - October 26, 2021 Category: Endocrinology Authors: Sara SantaCruz-Calvo Leena Bharath Gabriella Pugh Lucia SantaCruz-Calvo Raji Rajesh Lenin Jenny Lutshumba Rui Liu Adam D. Bachstetter Beibei Zhu Barbara S. Nikolajczyk Source Type: research

GnRH pulses affect ageing in male mice
Nature Reviews Endocrinology, Published online: 25 October 2021; doi:10.1038/s41574-021-00592-0GnRH pulses affect ageing in male mice (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - October 25, 2021 Category: Endocrinology Authors: Claire Greenhill Source Type: research

Potential role for follicular Treg cells in T1DM
Nature Reviews Endocrinology, Published online: 25 October 2021; doi:10.1038/s41574-021-00591-1Potential role for follicular Treg cells in T1DM (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - October 25, 2021 Category: Endocrinology Authors: Claire Greenhill Source Type: research

Phase IIa results for potential NAFLD therapy
Nature Reviews Endocrinology, Published online: 25 October 2021; doi:10.1038/s41574-021-00590-2Phase IIa results for potential NAFLD therapy (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - October 25, 2021 Category: Endocrinology Authors: Claire Greenhill Source Type: research

GnRH pulses affect ageing in male mice
Nature Reviews Endocrinology, Published online: 25 October 2021; doi:10.1038/s41574-021-00592-0GnRH pulses affect ageing in male mice (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - October 25, 2021 Category: Endocrinology Authors: Claire Greenhill Source Type: research

Potential role for follicular Treg cells in T1DM
Nature Reviews Endocrinology, Published online: 25 October 2021; doi:10.1038/s41574-021-00591-1Potential role for follicular Treg cells in T1DM (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - October 25, 2021 Category: Endocrinology Authors: Claire Greenhill Source Type: research