Obesity — no role for pro-inflammatory liver macrophages
Obesity — no role for pro-inflammatory liver macrophagesObesity — no role for pro-inflammatory liver macrophages, Published online: 16 April 2019; doi:10.1038/s41574-019-0207-5Obesity — no role for pro-inflammatory liver macrophages (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - April 16, 2019 Category: Endocrinology Authors: Alan Morris Source Type: research

Understanding lipid metabolism through hepatic steat-omics
Understanding lipid metabolism through hepatic steat-omics, Published online: 12 April 2019; doi:10.1038/s41574-019-0203-9Alterations in lipid metabolism are closely linked to disorders such as cardiovascular disease, type 2 diabetes mellitus and non-alcoholic fatty liver disease. A multi-omics study on a mouse genetic reference panel uncovers regulatory networks and potential biomarkers of hepatic lipid metabolism. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - April 12, 2019 Category: Endocrinology Authors: Joel T. Haas Bart Staels Source Type: research

SCFAs — the thin microbial metabolic line between good and bad
SCFAs — the thin microbial metabolic line between good and badSCFAs — the thin microbial metabolic line between good and bad, Published online: 11 April 2019; doi:10.1038/s41574-019-0205-7By combining genetic, metagenomic and metabolic data in humans, a recent study has identified causal relationships between the capacity of gut microorganisms to produce short-chain fatty acids, such as butyrate and propionate, and metabolic traits of the host, including insulin response during an oral glucose tolerance test and susceptibility to type 2 diabetes mellitus. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - April 11, 2019 Category: Endocrinology Authors: Matteo Serino Source Type: research

Insulin and the insulin receptor regulate gene expression
Insulin and the insulin receptor regulate gene expression, Published online: 11 April 2019; doi:10.1038/s41574-019-0206-6Insulin and the insulin receptor regulate gene expression (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - April 11, 2019 Category: Endocrinology Authors: Claire Greenhill Source Type: research

Longevity is innate
Longevity is innate, Published online: 09 April 2019; doi:10.1038/s41574-019-0202-xLongevity is innate (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - April 9, 2019 Category: Endocrinology Authors: Shimona Starling Source Type: research

Improving pregnancy outcomes in women with diabetes mellitus: modern management
Improving pregnancy outcomes in women with diabetes mellitus: modern management, Published online: 04 April 2019; doi:10.1038/s41574-019-0197-3Women with pre-existing diabetes mellitus are at increased risk of complications during pregnancy. This Review outlines the latest management strategies that have been designed to reduce this risk, including diet and pharmacotherapy options. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - April 4, 2019 Category: Endocrinology Authors: Lene Ringholm Peter Damm Elisabeth R. Mathiesen Source Type: research

Subtyping obesity
Subtyping obesity, Published online: 04 April 2019; doi:10.1038/s41574-019-0201-ySubtyping obesity (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - April 4, 2019 Category: Endocrinology Authors: Alan Morris Source Type: research

TH at the heart of the matter
TH at the heart of the matter, Published online: 04 April 2019; doi:10.1038/s41574-019-0200-zTH at the heart of the matter (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - April 4, 2019 Category: Endocrinology Authors: Anna Kriebs Source Type: research

Author Correction: Epidemic T2DM, early development and epigenetics: implications of the Chinese Famine
Author Correction: Epidemic T2DM, early development and epigenetics: implications of the Chinese Famine, Published online: 01 April 2019; doi:10.1038/s41574-019-0199-1Author Correction: Epidemic T2DM, early development and epigenetics: implications of the Chinese Famine (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - April 1, 2019 Category: Endocrinology Authors: Paul Zimmet Zumin Shi Assam El-Osta Linong Ji Source Type: research

Prolactin — a pleiotropic factor in health and disease
Prolactin — a pleiotropic factor in health and diseaseProlactin — a pleiotropic factor in health and disease, Published online: 21 March 2019; doi:10.1038/s41574-019-0194-6Prolactin is mainly known for its involvement in the regulation of lactation. In this Review, the authors describe other newly discovered roles of prolactin in human health and disease and discuss new data on the pathological states of hypoprolactinaemia and hyperprolactinaemia. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 21, 2019 Category: Endocrinology Authors: Val érie Bernard Jacques Young Nadine Binart Source Type: research

The effect of the Chinese Famine on type 2 diabetes mellitus epidemics
The effect of the Chinese Famine on type 2 diabetes mellitus epidemics, Published online: 21 March 2019; doi:10.1038/s41574-019-0195-5The Chinese Famine has been widely interpreted as an important contributor to subsequent epidemics of type 2 diabetes mellitus. Our re-examination of available studies challenges this apparent relationship. The definition of famine exposure and control selection needs more attention in future studies to better understand this potential association. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 21, 2019 Category: Endocrinology Authors: Chihua Li Elmar W. Tobi Bastiaan T. Heijmans L. H. Lumey Source Type: research

Carbohydrate quality is key for a healthy and sustainable diet
Carbohydrate quality is key for a healthy and sustainable diet, Published online: 19 March 2019; doi:10.1038/s41574-019-0190-xThe quality of carbohydrate-rich foods rather than quantity has the strongest effect on major health outcomes. Systematic reviews and meta-analyses of prospective studies report lower mortality and reduced incidence of cardiovascular diseases, type 2 diabetes mellitus and colorectal cancer in people who habitually consume diets rich in fibre and whole grain. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 19, 2019 Category: Endocrinology Authors: Gabriele Riccardi Giuseppina Costabile Source Type: research

Genesis, genes and epigenetics of endometriosis-associated infertility
Genesis, genes and epigenetics of endometriosis-associated infertility, Published online: 18 March 2019; doi:10.1038/s41574-019-0191-9Jae-Wook Jeong and colleagues report that histone deacetylase 3 (HDAC3) is downregulated in the endometrium of women with endometriosis. In addition, they show that the loss of HDAC3 is associated with aberrant hormonal signalling and increased fibrosis in the endometrium and impaired endometrial receptivity. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 18, 2019 Category: Endocrinology Authors: Sun-Wei Guo Source Type: research

The role of thyroglobulin in thyroid hormonogenesis
The role of thyroglobulin in thyroid hormonogenesis, Published online: 18 March 2019; doi:10.1038/s41574-019-0184-8T3 and T4 are synthesized in the thyroid gland in a process that involves the iodoglycoprotein thyroglobulin. In this Review, we consider the role of thyroglobulin in thyroid hormonogenesis from evolutionary, biochemical, molecular, cellular and physiological angles. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 18, 2019 Category: Endocrinology Authors: Cintia E. Citterio H éctor M. Targovnik Peter Arvan Source Type: research

Neuronal clock coordinates appetite
Neuronal clock coordinates appetite, Published online: 18 March 2019; doi:10.1038/s41574-019-0196-4Neuronal clock coordinates appetite (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 18, 2019 Category: Endocrinology Authors: Shimona Starling Source Type: research

Key pathways revealed in rare thyroid cancer
Key pathways revealed in rare thyroid cancer, Published online: 13 March 2019; doi:10.1038/s41574-019-0193-7Key pathways revealed in rare thyroid cancer (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 13, 2019 Category: Endocrinology Authors: Shimona Starling Source Type: research

The reconstructed natural history of type 1 diabetes mellitus
The reconstructed natural history of type 1 diabetes mellitus, Published online: 11 March 2019; doi:10.1038/s41574-019-0192-8The causes of type 1 diabetes mellitus (T1DM) are unclear; however, a general consensus exists that T1DM is a T cell-mediated autoimmune disease characterized by the selective destruction of insulin-secreting β-cells. Now, two imaging mass cytometry studies of human pancreatic tissue illuminate new biology in the pathogenesis of T1DM. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 11, 2019 Category: Endocrinology Authors: Paolo Pozzilli Alberto Signore Source Type: research

Adrenal function and dysfunction in critically ill patients
Adrenal function and dysfunction in critically ill patients, Published online: 08 March 2019; doi:10.1038/s41574-019-0185-7In this Review, new insights into the hypothalamic–pituitary–adrenal axis are integrated within a novel conceptual framework that can be used to re-appreciate adrenocortical function and dysfunction in the context of critical illness. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 8, 2019 Category: Endocrinology Authors: Arno T éblick Bram Peeters Lies Langouche Greet Van den Berghe Source Type: research

Overgrowth syndromes — clinical and molecular aspects and tumour risk
Overgrowth syndromes — clinical and molecular aspects and tumour riskOvergrowth syndromes — clinical and molecular aspects and tumour risk, Published online: 06 March 2019; doi:10.1038/s41574-019-0180-zOvergrowth syndromes are a heterogeneous group of rare disorders characterized by generalized or segmental excessive growth. This Review discusses the clinical and molecular diagnosis, tumour risk and recommendations for tumour screening for the most prevalent generalized and segmental overgrowth syndromes. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 6, 2019 Category: Endocrinology Authors: Fr édéric Brioude Annick Toutain Eloise Giabicani Edouard Cottereau Val érie Cormier-Daire Irene Netchine Source Type: research

Endocrine disruptors and the future of toxicology testing — lessons from CLARITY–BPA
Endocrine disruptors and the future of toxicology testing — lessons from CLARITY–BPAEndocrine disruptors and the future of toxicology testing — lessons from CLARITY–BPA, Published online: 06 March 2019; doi:10.1038/s41574-019-0173-yThe aim of the Consortium Linking Academic and Regulatory Insights on Toxicity of BPA (CLARITY–BPA) was to provide a definitive evaluation of bisphenol A (BPA). In this Perspectives, the authors summarize the goals, design and problems of CLARITY–BPA. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 6, 2019 Category: Endocrinology Authors: Laura N. Vandenberg Patricia A. Hunt Andrea C. Gore Source Type: research

Physical activity and muscle–brain crosstalk
Physical activity and muscle–brain crosstalkPhysical activity and muscle–brain crosstalk, Published online: 05 March 2019; doi:10.1038/s41574-019-0174-xExercise has many beneficial effects on brain health, but how exercise is sensed by the brain has not been well understood. This Review describes evidence that supports the existence of a muscle–brain endocrine loop, in which muscle-induced peripheral factors enable direct crosstalk between muscle and brain. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 5, 2019 Category: Endocrinology Authors: Bente Klarlund Pedersen Source Type: research

What makes bones grow?
What makes bones grow?, Published online: 05 March 2019; doi:10.1038/s41574-019-0189-3What makes bones grow? (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 5, 2019 Category: Endocrinology Authors: Claire Greenhill Source Type: research

Reducing food intake with a gut hormone analogue
Reducing food intake with a gut hormone analogue, Published online: 04 March 2019; doi:10.1038/s41574-019-0187-5Reducing food intake with a gut hormone analogue (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 4, 2019 Category: Endocrinology Authors: Claire Greenhill Source Type: research

Low-calorie diets in the management of type 2 diabetes mellitus
Low-calorie diets in the management of type 2 diabetes mellitus, Published online: 04 March 2019; doi:10.1038/s41574-019-0186-6Type 2 diabetes mellitus is common, disabling and expensive, despite improved glucose-lowering management and guidelines. Its dominant cause is weight gain, with ectopic fat accumulation in vital organs, reflected by a large waist circumference. Addressing the underlying cause, by low-calorie formula diets and integrated support for long-term weight-loss maintenance, produces remissions in almost half the treated population. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 4, 2019 Category: Endocrinology Authors: Michael E. J. Lean Source Type: research

Human islets show plasticity
Human islets show plasticity, Published online: 04 March 2019; doi:10.1038/s41574-019-0188-4Human islets show plasticity (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 4, 2019 Category: Endocrinology Authors: Alan Morris Source Type: research

Obesity: global epidemiology and pathogenesis
Obesity: global epidemiology and pathogenesis, Published online: 27 February 2019; doi:10.1038/s41574-019-0176-8The prevalence of obesity has increased worldwide in the past ~50 years, reaching pandemic levels. Remarkable regional differences exist in obesity prevalence and trends, which might help to identify societal causes of obesity and provide guidance for the most promising intervention strategies. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - February 27, 2019 Category: Endocrinology Authors: Matthias Bl üher Source Type: research

Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity
Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity, Published online: 27 February 2019; doi:10.1038/s41574-019-0170-1This Review discusses how signals arising from activity are perceived by cell populations and how the cells respond to them, with particular emphasis on the musculoskeletal and adipose systems. The potential of exercise as a non-invasive and non-pharmacological method of regulating osteoporosis and obesity is also outlined. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - February 27, 2019 Category: Endocrinology Authors: Gabriel M. Pagnotti Maya Styner Gunes Uzer Vihitaben S. Patel Laura E. Wright Kirsten K. Ness Theresa A. Guise Janet Rubin Clinton T. Rubin Source Type: research

Breakfast not beneficial for weight loss
Breakfast not beneficial for weight loss, Published online: 20 February 2019; doi:10.1038/s41574-019-0182-xBreakfast not beneficial for weight loss (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - February 20, 2019 Category: Endocrinology Authors: Alan Morris Source Type: research

A new metabolic role for TGFβ2
A new metabolic role for TGFβ2A new metabolic role for TGFβ2, Published online: 20 February 2019; doi:10.1038/s41574-019-0183-9A new metabolic role for TGFβ2 (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - February 20, 2019 Category: Endocrinology Authors: Shimona Starling Source Type: research

Imaging β-cell function in vivo
Imaging β-cell function in vivoImaging β-cell function in vivo, Published online: 19 February 2019; doi:10.1038/s41574-019-0181-yImaging β-cell function in vivo (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - February 19, 2019 Category: Endocrinology Authors: Shimona Starling Source Type: research

An insulin pill
An insulin pill, Published online: 18 February 2019; doi:10.1038/s41574-019-0179-5An insulin pill (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - February 18, 2019 Category: Endocrinology Authors: Anna Kriebs Source Type: research

Exercise prevents fall-related injuries in older people
Exercise prevents fall-related injuries in older people, Published online: 18 February 2019; doi:10.1038/s41574-019-0175-9Long-term exercise is an important lifestyle factor that can substantially improve the health of older individuals. A new meta-analysis and systematic review builds on previous studies and provides further evidence that exercise interventions can prevent fall-related injuries and fractures in people aged>60 years. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - February 18, 2019 Category: Endocrinology Authors: Stephen Lord Source Type: research

T cells in gut linked to metabolism
T cells in gut linked to metabolism, Published online: 15 February 2019; doi:10.1038/s41574-019-0177-7T cells in gut linked to metabolism (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - February 15, 2019 Category: Endocrinology Authors: Alan Morris Source Type: research

Balancing glucose levels after bariatric surgery — an important role for GLP1
Balancing glucose levels after bariatric surgery — an important role for GLP1Balancing glucose levels after bariatric surgery — an important role for GLP1, Published online: 14 February 2019; doi:10.1038/s41574-019-0178-6Balancing glucose levels after bariatric surgery — an important role for GLP1 (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - February 14, 2019 Category: Endocrinology Authors: Claire Greenhill Source Type: research

Function and mechanisms of enteroendocrine cells and gut hormones in metabolism
Function and mechanisms of enteroendocrine cells and gut hormones in metabolism, Published online: 13 February 2019; doi:10.1038/s41574-019-0168-8The gut secretes approximately 20 active hormones with overlapping targets and actions. This Review focuses on the molecular mechanisms underlying the modulation of gut hormone release by food ingestion, obesity and the gut microbiota. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - February 13, 2019 Category: Endocrinology Authors: Fiona M. Gribble Frank Reimann Source Type: research

Islets form as peninsulas
Islets form as peninsulas, Published online: 08 February 2019; doi:10.1038/s41574-019-0172-zIslets form as peninsulas (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - February 8, 2019 Category: Endocrinology Authors: Shimona Starling Source Type: research

Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus
Molecular pathways linking adipose innervation to insulin action in obesity and diabetes mellitus, Published online: 07 February 2019; doi:10.1038/s41574-019-0165-yThis Review examines the signalling between cells resident in adipose tissue and local sensory and sympathetic nerve fibres. The potential of targeting these processes in new therapeutics for metabolic diseases is also discussed. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - February 7, 2019 Category: Endocrinology Authors: Adilson Guilherme Felipe Henriques Alexander H. Bedard Michael P. Czech Source Type: research

A healthy lifestyle — reducing T2DM risk in shift workers?
A healthy lifestyle — reducing T2DM risk in shift workers?A healthy lifestyle — reducing T2DM risk in shift workers?, Published online: 04 February 2019; doi:10.1038/s41574-019-0164-zA recent study shows that a history of rotating night-shift work and an unhealthy lifestyle are associated with increased risk of type 2 diabetes mellitus (T2DM), both independently and synergistically. This is the first large-scale, prospective study to quantify how a healthy lifestyle might partially offset T2DM risk in shift workers. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - February 4, 2019 Category: Endocrinology Authors: C éline Vetter Frank A. J. L. Scheer Source Type: research

Development of melanocortin circuits
Development of melanocortin circuits, Published online: 01 February 2019; doi:10.1038/s41574-019-0171-0Development of melanocortin circuits (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - February 1, 2019 Category: Endocrinology Authors: Claire Greenhill Source Type: research

GDF15 signals nutritional stress
GDF15 signals nutritional stress, Published online: 28 January 2019; doi:10.1038/s41574-019-0167-9GDF15 signals nutritional stress (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 28, 2019 Category: Endocrinology Authors: Shimona Starling Source Type: research

Anxiety-induced weight loss
Anxiety-induced weight loss, Published online: 28 January 2019; doi:10.1038/s41574-019-0169-7Anxiety-induced weight loss (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 28, 2019 Category: Endocrinology Authors: Alan Morris Source Type: research

Treating T2DM by ensuring insulin access is a global challenge
Treating T2DM by ensuring insulin access is a global challenge, Published online: 25 January 2019; doi:10.1038/s41574-019-0160-3As the global increase in type 2 diabetes mellitus has a steep upward slope, meeting the worldwide demand for insulin is an international challenge. Sanjay Basu and colleagues used microsimulation to create scenarios that can inform the design of health-care strategies and insulin requirements for governments and the national and international organizations responsible for formulating treatment guidelines. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 25, 2019 Category: Endocrinology Authors: Margrethe F. Horlyck-Romanovsky Anne E. Sumner Source Type: research

Individual response to diabetes therapy
Individual response to diabetes therapy, Published online: 24 January 2019; doi:10.1038/s41574-019-0166-xIndividual response to diabetes therapy (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 24, 2019 Category: Endocrinology Authors: Claire Greenhill Source Type: research

Motilin: from gastric motility stimulation to hunger signalling
Motilin: from gastric motility stimulation to hunger signalling, Published online: 23 January 2019; doi:10.1038/s41574-019-0155-0Interest in motilin is growing, as several studies have shown its relevance in the control of hunger and regulation of food intake in both health and disease. The current state of knowledge and implications for therapy are summarized in this Review. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 23, 2019 Category: Endocrinology Authors: Eveline Deloose Wout Verbeure Inge Depoortere Jan Tack Source Type: research

The ‘obesity paradox’ in action with cancer immunotherapy
The ‘obesity paradox’ in action with cancer immunotherapyThe ‘obesity paradox’ in action with cancer immunotherapy, Published online: 22 January 2019; doi:10.1038/s41574-019-0161-2A recent study has shown that obesity and ageing induce T cell dysfunction and an upregulation of programmed cell death 1 (PD-1) on T cells across species, which is partially mediated by leptin. However, the polarization of T cells towards an exhaustive phenotype correlated with improved response rates to anti-PD-1 therapy in the setting of obesity. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 22, 2019 Category: Endocrinology Authors: Joanne Lysaght Source Type: research

Gut microbial metabolites in obesity, NAFLD and T2DM
Gut microbial metabolites in obesity, NAFLD and T2DM, Published online: 22 January 2019; doi:10.1038/s41574-019-0156-zIn this Review, the authors explore the role of gut microbial metabolites derived from carbohydrate fermentation and protein fermentation in body weight control, nonalcoholic fatty liver disease, insulin resistance and type 2 diabetes mellitus. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 22, 2019 Category: Endocrinology Authors: Emanuel E. Canfora Ruth C. R. Meex Koen Venema Ellen E. Blaak Source Type: research

Potential treatment strategy for NASH
Potential treatment strategy for NASH, Published online: 21 January 2019; doi:10.1038/s41574-019-0162-1Potential treatment strategy for NASH (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 21, 2019 Category: Endocrinology Authors: Alan Morris Source Type: research

A new class of AR antagonists?
A new class of AR antagonists?, Published online: 21 January 2019; doi:10.1038/s41574-019-0163-0A new class of AR antagonists? (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 21, 2019 Category: Endocrinology Authors: Annette Fenner Source Type: research

Circadian rhythms and exercise — re-setting the clock in metabolic disease
Circadian rhythms and exercise — re-setting the clock in metabolic diseaseCircadian rhythms and exercise — re-setting the clock in metabolic disease, Published online: 17 January 2019; doi:10.1038/s41574-018-0150-xExercise is used to prevent and treat metabolic diseases. Finding the optimum time for exercise is important as skeletal muscle has many clock-controlled genes. This Review summarizes the current literature regarding the consequence of exercise at different times of the day. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 17, 2019 Category: Endocrinology Authors: Brendan M. Gabriel Juleen R. Zierath Source Type: research

Drivers of islet inflammation
Drivers of islet inflammation, Published online: 17 January 2019; doi:10.1038/s41574-019-0159-9Drivers of islet inflammation (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - January 17, 2019 Category: Endocrinology Authors: Shimona Starling Source Type: research