Mild autonomous cortisol secretion: pathophysiology, comorbidities and management approaches
Nature Reviews Endocrinology, Published online: 22 April 2024; doi:10.1038/s41574-024-00984-yMild autonomous cortisol secretion from benign adrenocortical adenomas (usually diagnosed incidentally) is associated with cardiometabolic risk and other comorbidities, but without the signs of overt Cushing syndrome. This Review outlines the mechanisms, complications and comorbidities, diagnosis and management of mild autonomous cortisol secretion. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - April 22, 2024 Category: Endocrinology Authors: Alessandro Prete Irina Bancos Source Type: research
Targeting the incretin system in obesity and type 2 diabetes mellitus
This article reviews advances in incretin-based pharmacotherapy, including the latest glucagon-like peptide 1 (GLP1) receptor agonists (GLP1RAs), ‘GLP1 plus’ agents, which combine the benefits of these agonists with the activity of additional hormones, and oral GLP1RAs, which promise to extend the benefits of GLP1 therapy. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - April 17, 2024 Category: Endocrinology Authors: Saleem Ansari Bernard Khoo Tricia Tan Source Type: research
A novel system for non-invasive measurement of blood levels of glucose
Nature Reviews Endocrinology, Published online: 17 April 2024; doi:10.1038/s41574-024-00988-8A novel system for non-invasive measurement of blood levels of glucose (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - April 17, 2024 Category: Endocrinology Authors: Olivia Tysoe Source Type: research
Continuous glucose monitoring for the routine care of type 2 diabetes mellitus
Nature Reviews Endocrinology, Published online: 08 April 2024; doi:10.1038/s41574-024-00973-1Continuous glucose monitoring (CGM) is an effective tool in the management of diabetes mellitus. This Perspective discusses the potential benefits of widespread adoption of CGM in people with type 2 diabetes mellitus at different stages of disease progression and treatment intensification. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - April 8, 2024 Category: Endocrinology Authors: Ramzi A. Ajjan Tadej Battelino Xavier Cos Stefano Del Prato Jean-Christophe Philips Laurent Meyer Jochen Seufert Samuel Seidu Source Type: research
Metformin acts through appetite-suppressing metabolite: Lac-Phe
Nature Reviews Endocrinology, Published online: 02 April 2024; doi:10.1038/s41574-024-00986-wMetformin acts through appetite-suppressing metabolite: Lac-Phe (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - April 2, 2024 Category: Endocrinology Authors: Shimona Starling Source Type: research
Protein tyrosine phosphatase 1B in metabolic diseases and drug development
Nature Reviews Endocrinology, Published online: 22 March 2024; doi:10.1038/s41574-024-00965-1This Review summarizes cellular processes and regulation of protein tyrosine phosphatase 1B (PTP1B), discussing evidence from in vivo preclinical and human studies. PTP1B inhibitors, which are being developed for type 2 diabetes mellitus, obesity, rare diseases (such as Rett syndrome) and some cancers, are also discussed. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 22, 2024 Category: Endocrinology Authors: Mirela Delibegovi ć Sergio Dall ’Angelo Ruta Dekeryte Source Type: research
Endocrine and cellular physiology and pathology of the insulin-like growth factor acid-labile subunit
Nature Reviews Endocrinology, Published online: 21 March 2024; doi:10.1038/s41574-024-00970-4The acid-labile subunit (ALS) of the insulin-like growth factor (IGF) binding protein complex regulates the endocrine transport and bioavailability of IGF-1 and IGF-2 and therefore influences postnatal growth and metabolism. This Review addresses the endocrine physiology and pathology of ALS, discusses the emerging cellular roles for ALS and outlines its involvement in disease states. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 21, 2024 Category: Endocrinology Authors: Robert C. Baxter Source Type: research
Slowly progressive insulin-dependent diabetes mellitus in type 1 diabetes endotype 2
Nature Reviews Endocrinology, Published online: 21 March 2024; doi:10.1038/s41574-024-00975-zSlowly progressive insulin-dependent diabetes mellitus in type 1 diabetes endotype 2 (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 21, 2024 Category: Endocrinology Authors: Tetsuro Kobayashi Takashi Kadowaki Source Type: research
Reply to ‘Slowly progressive insulin dependent diabetes mellitus in type 1 diabetes endotype 2’
Nature Reviews Endocrinology, Published online: 21 March 2024; doi:10.1038/s41574-024-00977-xReply to ‘Slowly progressive insulin dependent diabetes mellitus in type 1 diabetes endotype 2’ (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 21, 2024 Category: Endocrinology Authors: Maria J. Redondo Noel G. Morgan Source Type: research
The hypothalamic–pituitary–gonadal axis and the enigma of Alzheimer disease sex differences
Nature Reviews Endocrinology, Published online: 21 March 2024; doi:10.1038/s41574-024-00981-1Alzheimer disease has a sex bias: women are twice as likely as men to be affected. Studies have linked elevated follicle-stimulating hormone (FSH) levels to worsened Alzheimer disease pathology and cognitive decline in mice. Exploring the interaction of FSH with APOE4 has uncovered new aspects of Alzheimer disease. The therapeutic potential of FSH and gonadotropin-releasing hormone have also been highlighted. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 21, 2024 Category: Endocrinology Authors: Florent Sauv é Lo ïc Kacimi Vincent Pr évot Source Type: research
Reply to ‘Tumour fibrosis in dopamine agonist-exposed prolactinomas is a diminishing concern’
Nature Reviews Endocrinology, Published online: 20 March 2024; doi:10.1038/s41574-024-00978-wReply to ‘Tumour fibrosis in dopamine agonist-exposed prolactinomas is a diminishing concern’ (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 20, 2024 Category: Endocrinology Authors: Stephan Petersenn Maria Fleseriu Shlomo Melmed Source Type: research
Sex differences in diabetic kidney disease explained
Nature Reviews Endocrinology, Published online: 20 March 2024; doi:10.1038/s41574-024-00982-0Sex differences in diabetic kidney disease explained (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 20, 2024 Category: Endocrinology Authors: Claire Greenhill Source Type: research
Tumour fibrosis in dopamine agonist-exposed prolactinomas is a diminishing concern
Nature Reviews Endocrinology, Published online: 20 March 2024; doi:10.1038/s41574-024-00976-yTumour fibrosis in dopamine agonist-exposed prolactinomas is a diminishing concern (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 20, 2024 Category: Endocrinology Authors: Sunita M. C. De Sousa Alistair K. Jukes Nicholas G. Candy Ian M. Chapman David J. Torpy Brindha Shivalingam Peter-John Wormald Stephen Santoreneos Source Type: research
Metabolic regulation of skeletal cell fate and function
Nature Reviews Endocrinology, Published online: 18 March 2024; doi:10.1038/s41574-024-00969-xThe skeleton is a metabolically active organ, with bone formation and maintenance relying on highly anabolic, nutrient-consuming processes. Here, the authors describe the current understanding of fuel selection and intermediary metabolic pathways in bone cells during bone formation and discuss how metabolic dysfunction can contribute to skeletal disease. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 18, 2024 Category: Endocrinology Authors: Steve Stegen Geert Carmeliet Source Type: research
Inceptor loss in mice with obesity
Nature Reviews Endocrinology, Published online: 18 March 2024; doi:10.1038/s41574-024-00980-2Inceptor loss in mice with obesity (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - March 18, 2024 Category: Endocrinology Authors: Shimona Starling Source Type: research
