Gamma-Band Auditory Steady-State Response as a Neurophysiological Marker for Excitation and Inhibition Balance: A Review for Understanding Schizophrenia and Other Neuropsychiatric Disorders.
Abstract Altered gamma oscillations have attracted considerable attention as an index of the excitation/inhibition (E/I) imbalance in schizophrenia and other neuropsychiatric disorders. The auditory steady-state response (ASSR) has been the most robust probe of abnormal gamma oscillatory dynamics in schizophrenia. Here, we review recent ASSR studies in patients with schizophrenia and other neuropsychiatric disorders. Preclinical ASSR research, which has contributed to the elucidation of the underlying pathophysiology of these diseases, is also discussed. The developmental trajectory of the ASSR has been explored a...
Source: Clinical EEG and Neuroscience - August 12, 2019 Category: Neuroscience Authors: Tada M, Kirihara K, Koshiyama D, Fujioka M, Usui K, Uka T, Komatsu M, Kunii N, Araki T, Kasai K Tags: Clin EEG Neurosci Source Type: research

Deficit Effect Sizes and Correlations of Auditory Event-Related Potentials at First Hospitalization in the Schizophrenia Spectrum.
We examined effect sizes of, and correlations between, N1, P2, P3, and MMN in 106 FESz and 114 matched psychiatrically well controls to determine which ERPs maximally differentiated groups, and whether late sensory/perceptual deficits (N1, P2) affected preattentive memory (MMN) and conscious attention (P3). Furthermore, we compared hallucinators and nonhallucinators within FESz. Participants completed 1 of 3 oddball tasks, silently counting target tones among standard tones. Sixty-seven FESz and 72 matched participants also completed pitch-deviant MMN testing. Measures were z-scored from task appropriate controls before me...
Source: Clinical EEG and Neuroscience - August 7, 2019 Category: Neuroscience Authors: Salisbury DF, Kohler J, Shenton ME, McCarley RW Tags: Clin EEG Neurosci Source Type: research

Deficit Versus Nondeficit Schizophrenia: An MEG-EEG Investigation of Resting State and Source Coherence-Preliminary Data.
This study investigated the magneto- and electroencephalography (MEG and EEG, respectively) resting state to identify the deviations closely associated with the deficit syndrome (DS) in schizophrenia patients. Ten subjects in each group (control, DS, and nondeficit schizophrenia [NDS]) were included. Subjects underwent MEG-EEG recordings during a resting state condition. MEG coherence source imaging (CSI) in source space and spectral analysis in sensor space were performed. Significant differences were found between the 2 patient groups: (1) MEG and EEG spectral analysis showed significantly higher power at low frequencies...
Source: Clinical EEG and Neuroscience - August 4, 2019 Category: Neuroscience Authors: Gjini K, Bowyer SM, Wang F, Boutros NN Tags: Clin EEG Neurosci Source Type: research

Electroencephalogram Characteristics in Critical Ill Patients Before Cardiac Arrest: A Case Series.
Abstract Background/Objectives. To illustrate characteristic electroencephalogram (EEG) features in patients prior to their first cardiac arrest. Methods. We identified 15 patients who suffered cardiac arrest during continuous EEG at our institution from June 2016 to June 2019. Eight patients were excluded due to co-administration of intravenous anesthetics (which may confound EEG) or if they had a previous prolonged cardiac arrest (>5 minutes) during the same hospitalization. We collected background information, analyzed the time span and vital signs between the initial background change and cardiac arrest. Re...
Source: Clinical EEG and Neuroscience - July 29, 2019 Category: Neuroscience Authors: Xu J, Mohamed W, Basha MM, Zutshi D Tags: Clin EEG Neurosci Source Type: research

A New Method of Diagnosing Attention-Deficit Hyperactivity Disorder in Male Patients by Quantitative EEG Analysis.
In this study, we attempted to develop a new method for differentiating between male with and without ADHD by analyzing EEG features. Thirty boys with ADHD combined type (aged 8 years 5 months ± 1 year 11 months) and 30 age-matched controls (aged 8 years 5 months ± 1 year 8 months) were enrolled in this study. A classification analysis-based approach comprising training and classification phases was developed for classifying each subject's EEG features as ADHD or non-ADHD. Eight crucial feature descriptors were selected and ranked based on the t test. Compared with TBR in our study, the developed method had a...
Source: Clinical EEG and Neuroscience - July 19, 2019 Category: Neuroscience Authors: Chang MY, Ouyang CS, Chiang CT, Yang RC, Wu RC, Wu HC, Lin LC Tags: Clin EEG Neurosci Source Type: research

Probing the "Default Network Interference Hypothesis" With EEG: An RDoC Approach Focused on Attention.
Probing the "Default Network Interference Hypothesis" With EEG: An RDoC Approach Focused on Attention. Clin EEG Neurosci. 2019 Jul 19;:1550059419864461 Authors: Gerrits B, Vollebregt MA, Olbrich S, van Dijk H, Palmer D, Gordon E, Pascual-Marqui R, Kessels RPC, Arns M Abstract Studies have shown that specific networks (default mode network [DMN] and task positive network [TPN]) activate in an anticorrelated manner when sustaining attention. Related EEG studies are scarce and often lack behavioral validation. We performed independent component analysis (ICA) across different frequencies (sourc...
Source: Clinical EEG and Neuroscience - July 19, 2019 Category: Neuroscience Authors: Gerrits B, Vollebregt MA, Olbrich S, van Dijk H, Palmer D, Gordon E, Pascual-Marqui R, Kessels RPC, Arns M Tags: Clin EEG Neurosci Source Type: research

Transcranial Direct Current Stimulation for Treatment-Resistant Major Depression: A Double-Blind Randomized Sham-Controlled Trial.
Abstract In the current study, we tried to evaluate the effect of transcranial direct current stimulation (tDCS) on treatment-resistant major depression. We carried out a double-blind randomized sham-controlled trial was conducted in University Hospitals. Individuals with less than 50% decrease in the intensity of depression after 8 weeks of treatment with selective serotonin reuptake inhibitors were recruited. Thirty patients (16 women) with a mean (SD) age of 47.2 (12.0) years were randomly allocated to 2 groups. For the active group we administered 2-mA stimulation 20 minutes for each session, with 30 seconds r...
Source: Clinical EEG and Neuroscience - July 15, 2019 Category: Neuroscience Authors: Sharafi E, Taghva A, Arbabi M, Dadarkhah A, Ghaderi J Tags: Clin EEG Neurosci Source Type: research

Predictive Value of Slow and Fast EEG Oscillations for Methylphenidate Response in ADHD.
Abstract Attention-deficit/hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder and is characterized by symptoms of inattention and/or hyperactivity and impulsivity. In the current study, we obtained quantitative EEG (QEEG) recordings of 51 children aged between 6 and 12 years before the initiation of methylphenidate treatment. The relationship between changes in the scores of ADHD symptoms and initial QEEG features (power/power ratios values) were assessed. In addition, the children were classified as responder and nonresponder according to the ratio of their response to the medication (&g...
Source: Clinical EEG and Neuroscience - July 15, 2019 Category: Neuroscience Authors: Sari Gokten E, Tulay EE, Beser B, Elagoz Yuksel M, Arikan K, Tarhan N, Metin B Tags: Clin EEG Neurosci Source Type: research

The "MS-ROM/IFAST" Model, a Novel Parallel Nonlinear EEG Analysis Technique, Distinguishes ASD Subjects From Children Affected With Other Neuropsychiatric Disorders With High Degree of Accuracy.
Conclusions. These results confirm the possibility of an early automatic autism detection based on standard EEG. PMID: 31296052 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - July 11, 2019 Category: Neuroscience Authors: Grossi E, Buscema M, Della Torre F, Swatzyna RJ Tags: Clin EEG Neurosci Source Type: research

Borderline Personality and Bipolar Disorders Cannot Be Differentiated Electrophysiologically.
Conclusion. The findings suggested that these 2 clinical entities are biologically similar; however, further research should be performed to explain the basis clinical differences between the 2 disorders. PMID: 31282204 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - July 8, 2019 Category: Neuroscience Authors: Arikan MK, Metin B, Gunver MG, Tarhan N Tags: Clin EEG Neurosci Source Type: research

Investigation of Generalized EEG Paroxysms Accompanying Focal Epilepsies.
kan B Abstract Interictal focal EEG features were frequently observed in generalized, epilepsies, but there is limited information about interictal, epileptiform/nonepileptiform generalized paroxysms in focal epilepsies. We aimed to report the frequency and associated factors of generalized EEG discharges in focal epilepsy with unknown cause (FEUC) and mesial, temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). A total of 200 patients (FEUC in 90 patients; MTLE-HS in 110 patients) were included. Generalized epileptiform (spike/sharp waves simultaneously in all regions) and nonspecific generalized discharg...
Source: Clinical EEG and Neuroscience - June 28, 2019 Category: Neuroscience Authors: Atalar AÇ, Vanlı-Yavuz EN, Yılmaz E, Bebek N, Baykan B Tags: Clin EEG Neurosci Source Type: research

Relationship of Metacognition and Insight to Neural Synchronization and Cognitive Function in Early Phase Psychosis.
Abstract Metacognition is the process of thinking about one's own mental states. It involves a range of faculties that allow an individual to integrate information and form understanding of self and others, and use this understanding to respond to life challenges. Clinical insight is the awareness of one's mental illness, its consequences, and the need for treatment. Persons with psychotic disorders show impaired metacognition and insight, but the neurobiological bases for these impairments are not well characterized. We hypothesized that metacognition and insight may depend on capacity of neural circuits to synch...
Source: Clinical EEG and Neuroscience - June 26, 2019 Category: Neuroscience Authors: Leonhardt BL, Vohs JL, Bartolomeo LA, Visco A, Hetrick WP, Bolbecker AR, Breier A, Lysaker PH, O'Donnell BF Tags: Clin EEG Neurosci Source Type: research

EEG Findings in Posterior Reversible Encephalopathy Syndrome.
Conclusion. EEG findings in PRES are diverse, with no specific or even predominant pattern, based on this small sample size. PMID: 31215229 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - June 19, 2019 Category: Neuroscience Authors: Murray K, Amin U, Maciver S, Benbadis SR Tags: Clin EEG Neurosci Source Type: research

Evaluation of Neurofeedback for Posttraumatic Stress Disorder Related to Refugee Experiences Using Self-Report and Cognitive ERP Measures.
CONCLUSIONS: These preliminary observations are consistent with a possible benefit of neurofeedback for remediating PTSD. This may be achieved at least partially by an improvement in cognitive control. Further confirmation of the effectiveness of the treatment now requires a randomized controlled trial that considers issues such as placebo response, nonspecific therapist effects, and duration of treatment. PMID: 31132893 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - May 27, 2019 Category: Neuroscience Authors: Askovic M, Watters AJ, Coello M, Aroche J, Harris AWF, Kropotov J Tags: Clin EEG Neurosci Source Type: research

Resting State EEG Characteristics During Sedation With Midazolam or Propofol in Older Subjects.
CONCLUSION: Despite the different levels of light sedation with midazolam and propofol, similar changes in power were found. Functional connectivity and network topology showed differences between midazolam and propofol sedation. Future research should establish if these differences are caused by the different levels of sedation or the mechanism of action of these agents. PMID: 31106583 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - May 20, 2019 Category: Neuroscience Authors: Numan T, van Dellen E, Vleggaar FP, van Vlieberghe P, Stam CJ, Slooter AJC Tags: Clin EEG Neurosci Source Type: research

Event-Related Potential Analysis of ADHD and Control Adults During a Sustained Attention Task.
CONCLUSIONS: The differences in texture features obtained from t-f images of ERPs point toward altered information processing in adults with ADHD during a cognitive task. Findings of reduction in N1, N2, and P3 components highlight deficits of early sensory processing, stimulus categorization, and attentional resources, respectively, in adults with ADHD. PMID: 30997836 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - April 18, 2019 Category: Neuroscience Authors: Kaur S, Singh S, Arun P, Kaur D, Bajaj M Tags: Clin EEG Neurosci Source Type: research

Visual P300 Mind-Speller Brain-Computer Interfaces: A Walk Through the Recent Developments With Special Focus on Classification Algorithms.
This article is organized with a brief introduction to P300, concepts of visual P300 mind-spellers, the survey of literature with special focus on classification algorithms, followed by the discussion of various challenges and future directions. PMID: 30997842 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - April 18, 2019 Category: Neuroscience Authors: Philip JT, George ST Tags: Clin EEG Neurosci Source Type: research

Treatment of Medial Medullary Infarction Using a Novel iNems Training: A Case Report and Literature Review.
CONCLUSIONS: The newly developed iNems could prove a novel, useful tool for neurorehabilitation considering that both behavioral and neurophysiological changes were observed in our case. PMID: 30955363 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - April 7, 2019 Category: Neuroscience Authors: Kodama T, Katayama O, Nakano H, Ueda T, Murata S Tags: Clin EEG Neurosci Source Type: research

Continuous Electroencephalogram as a Biomarker of Disease Progression and Severity in Herpes Simplex Virus-1 Encephalitis.
We report the case of a patient with HSE who was monitored on CEEG and propose that CEEG can be used as a marker for progression of disease and thus may prompt escalation in therapy. While imaging studies may confirm spread of disease, using CEEG may prevent the delay of treatment and lead to more rapid therapy in cases of refractory HSE. PMID: 30873853 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - March 15, 2019 Category: Neuroscience Authors: Baten A, Desai M, Melo-Bicchi M, Gutierrez C Tags: Clin EEG Neurosci Source Type: research

Sex as a Moderating Factor in the Relationship Between Hippocampal Volume and Sensory Gating in Patients With Schizophrenia.
Abstract Building on the knowledge of sex differences in auditory sensory gating in schizophrenia and hippocampal involvement in sensory gating, this study aimed to investigate sex as a potential moderator of the association between hippocampal volume and P50 in schizophrenia. Auditory P50 gating and hippocampal volume were measured in 16 male and 15 female patients with schizophrenia. The correlations between hippocampal volume and P50 were analyzed in males and females separately, corrected for potential confounders, including age, duration of illness, and antipsychotic medication. Different associative patterns...
Source: Clinical EEG and Neuroscience - March 12, 2019 Category: Neuroscience Authors: Huang WL, Liu CY, Liu HM, Liu CM, Hsieh MH Tags: Clin EEG Neurosci Source Type: research

Atypical SREDA During Wakefulness, NREM and REM Sleep in a Young Teenager: A Diagnostic Challenge.
We report a case of atypical SREDA in a child that may have occurred in wakefulness, non-rapid eye movement (NREM) sleep, and REM sleep. This finding was initially misdiagnosed as epilepsy. Inpatient video-EEG demonstrated that during periods of SREDA in quiet wakefulness the patient did not have any signs or symptoms with the SREDA pattern; SREDA abated whenever the patient was alerted or if he spontaneously initiated some activities. SREDA with same morphology was noted in NREM and REM sleep. The patient had no true epileptogenic abnormalities and hence antiepileptic medication was discontinued and stopped uneventfully. ...
Source: Clinical EEG and Neuroscience - January 23, 2019 Category: Neuroscience Authors: Gil L, Moosa A, Gupta A Tags: Clin EEG Neurosci Source Type: research

Abnormalities of Alpha Activity in Frontocentral Region of the Brain as a Biomarker to Diagnose Adolescents With Bipolar Disorder.
CONCLUSION: Based on BD symptoms, especially inattention, increased alpha power is a rational finding which is associated with thalamus dysfunction. Thus, it seems that EEG alpha oscillation is the main source of abnormality in BD. Furthermore, EEG slowing in the depressive episode is related to inhibition of electrical activity and reduced cognitive functions. PMID: 30642197 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - January 14, 2019 Category: Neuroscience Authors: Khaleghi A, Mohammadi MR, Moeini M, Zarafshan H, Fadaei Fooladi M Tags: Clin EEG Neurosci Source Type: research

The Three Nociceptive Responses of the Orbicularis Oculi Reflex in Alzheimer's Disease: State of the Evidence and Meta-analysis.
Abstract There is an emerging belief that electrically elicited blink reflexes (BR) may distinguish Alzheimer's disease (AD) from other disorders characterized by memory dysfunction. To qualitatively and quantitatively distinguish the effects that electrical stimulation has over the blink reflex (eBR) recorded from patients with AD and healthy controls (HCs), we did a systematic review of the literature, and conducted a meta-analysis. Following our selected criteria, 94 AD patients and 97 HCs were identified from articles published in English between 1950 and 2017. Although the 3 responses (R1, R2 and R3) of the e...
Source: Clinical EEG and Neuroscience - January 14, 2019 Category: Neuroscience Authors: Leon-Ariza JS, Prada DG, Leon-Ariza DS, Castillo C, Leon-Sarmiento FE Tags: Clin EEG Neurosci Source Type: research

Binomial Logistic Regression and Artificial Neural Network Methods to Classify Opioid-Dependent Subjects and Control Group Using Quantitative EEG Power Measures.
In this study, we introduce the 2 aforementioned approaches in order to generate a model dichotomizing 75 opioid-dependent patients and 59 control subjects from each other. Quantitative electroencephalography (QEEG) absolute power value of each electrode were calculated for 4 consecutive frequency bands namely delta, theta, alpha, and beta with the frequencies, 0.5 to 4, 4 to 8, 8 to 12, and 12 to 20 Hz, respectively. Significant independent variables contributing to the classification were underlined in LR while a feature selection (FS) method, genetic algorithm, is being applied to the ANN model to reveal more informativ...
Source: Clinical EEG and Neuroscience - January 14, 2019 Category: Neuroscience Authors: Erguzel TT, Noyan CO, Eryilmaz G, Ünsalver BÖ, Cebi M, Tas C, Dilbaz N, Tarhan N Tags: Clin EEG Neurosci Source Type: research

Measuring Treatment Response in Pharmacological and Lifestyle Interventions Using Electroencephalography in ADHD: A Review.
Abstract Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity, and/or impulsivity with associations to short- and long-term aversive life events. The exact etiology of the disorder is still unknown. ADHD is heterogeneous in symptomology and a single consistent, reliable biomarker has not been found. Quantitative electroencephalography (EEG) has been proposed as a potential way to differentiate those with ADHD from typically developing controls; however, the data on the diagnostic utility of this approach have been variable. Quantitative EEG ha...
Source: Clinical EEG and Neuroscience - January 9, 2019 Category: Neuroscience Authors: Kirkland AE, Holton KF Tags: Clin EEG Neurosci Source Type: research

Entropy-Based Quantitative Electroencephalogram Analysis for Diagnosing Attention-Deficit Hyperactivity Disorder in Girls.
This study detailed the development of a method based on approximate entropy (ApEn) analysis of EEG to compare ADHD and control groups. Differences between ADHD presentation in boys and girls indicate the necessity of separate investigations. This study enrolled 30 girls with ADHD and 30 age-matched controls. The results revealed significantly higher ApEn values in most brain areas in the control group than in the ADHD group. Compared with TBR-related feature descriptors, ApEn-related feature descriptors can produce the higher average true positive rate (0.846), average true negative rate (0.814), average accuracy (0.817),...
Source: Clinical EEG and Neuroscience - November 29, 2018 Category: Neuroscience Authors: Chow JC, Ouyang CS, Tsai CL, Chiang CT, Yang RC, Wu RC, Wu HC, Lin LC Tags: Clin EEG Neurosci Source Type: research

Multifeature Mismatch Negativity in Patients With Posttraumatic Stress Disorder.
CONCLUSIONS: Choice of the stimulus protocol might be an important factor to explain inconsistent results in previous research. Differences in the auditory context between stimulus protocols and deficits in the formation of larger (auditory) contexts in PTSD might account for the results. SIGNIFICANCE: This study adds to the small number of studies on PTSD and MMN and revealed valuable information to guide future, related studies. PMID: 30497295 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - November 29, 2018 Category: Neuroscience Authors: Löw A, Frey JD, Gorzka R, Engers A, Wendt M, Höllmer H, Jacobsen T Tags: Clin EEG Neurosci Source Type: research

Event-Related Potentials Are Associated With Unexpected Gain and Loss: Using a Gambling Paradigm.
CONCLUSION: These results indicate that the paradigm is suitable to evoke specific patterns of reward-related electrophysiological responses. The wavelet analysis showed that electroencephalography frequency variations depended on the amount of gains/losses. SIGNIFICANCE: This gambling paradigm is appropriate to measure aspects of feedback processing and could help analyze disease-specific alterations of the reward system in patients. PMID: 30477341 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - November 27, 2018 Category: Neuroscience Authors: Krause D, Jobst A, Langemak SM, Keeser D, Chrobok AI, Langgartner S, Adorjan K, Gertzen M, Pogarell O, Karch S Tags: Clin EEG Neurosci Source Type: research

Auditory P300 as a Neurophysiological Correlate of Symptomatic Improvement by Transcranial Direct Current Stimulation in Patients With Schizophrenia: A Pilot Study.
CONCLUSIONS: Although this pilot study is limited by the small sample size and lack of a sham control, the results suggest that auditory P300 may be a putative marker reflecting the effect of tDCS on the positive and negative symptoms of schizophrenia. PMID: 30474393 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - November 25, 2018 Category: Neuroscience Authors: Kim M, Lee TH, Hwang WJ, Lee TY, Kwon JS Tags: Clin EEG Neurosci Source Type: research

EEG Neurofeedback Training in Children With Attention Deficit/Hyperactivity Disorder: A Cognitive and Behavioral Outcome Study.
CONCLUSION: The present study suggests that NFT is an effective method to enhance cognitive deficits and helps reduce ADHD symptoms and behavior problems. Consequently, academic performance was found to be improved in children with ADHD. Improvement in ADHD symptoms induced by NFT were maintained at 6-month follow-up in children with ADHD. PMID: 30453757 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - November 20, 2018 Category: Neuroscience Authors: Shereena EA, Gupta RK, Bennett CN, Sagar KJV, Rajeswaran J Tags: Clin EEG Neurosci Source Type: research

Association Between Positive Occipital Sharp Transients of Sleep and Lambda Waves.
Abstract Positive occipital sharp transients of sleep (POSTS) and lambda waves have similar morphology and location. We studied a possible association between these 2 normal EEG patterns. We reviewed a series of consecutive unselected ambulatory EEGs during a 3-month period (October 16, 2017 to January 19, 2018) and identified records with POSTS and records with lambda waves. Statistical analysis was performed using a chi-square test. A total of 140 ambulatory EEGs were reviewed. Duration of EEGs ranged from 24 to 168 hours (mean 76 hours). The population was 34% males, with ages ranging from 3 to 93 years (mean 4...
Source: Clinical EEG and Neuroscience - November 14, 2018 Category: Neuroscience Authors: Amin U, Sullivan L, Trudeau P, Benbadis SR Tags: Clin EEG Neurosci Source Type: research

EEG Resting-State Networks Responsible for Gait Disturbance Features in Idiopathic Normal Pressure Hydrocephalus.
In this study, using exact low-resolution brain electromagnetic tomography-independent component analysis (eLORETA-ICA) with electroencephalography (EEG) data, we assessed activities of five EEG resting-state networks (EEG-RSNs) in 58 iNPH patients before and after drainage of CSF by lumbar puncture (CSF tapping). In addition, we assessed correlations of changes in these five EEG-RSNs activities with CSF tapping-induced changes in iNPH symptoms. The results reveal that compared with 80 healthy controls, iNPH patients had significantly decreased activities in the occipital alpha rhythm, visual perception network, and self-r...
Source: Clinical EEG and Neuroscience - November 11, 2018 Category: Neuroscience Authors: Aoki Y, Kazui H, Pascual-Marqui RD, Ishii R, Yoshiyama K, Kanemoto H, Suzuki Y, Sato S, Azuma S, Suehiro T, Matsumoto T, Hata M, Canuet L, Iwase M, Ikeda M Tags: Clin EEG Neurosci Source Type: research

Quantitative and Qualitative Comparison of EEG-Based Neural Network Organization in Two Schizophrenia Groups Differing in the Duration of Illness and Disease Burden: Graph Analysis With Application of the Minimum Spanning Tree.
Abstract The aim of this study was to compare neural network topology of 30 patients with first episode schizophrenia (FES) and 30 multiepisode schizophrenia (mean number of psychotic relapses =4 years, duration of illness>5 years) patients, who were assessed with graph theory methods. This comparison was designed to identify network differences, which might be assigned to the burden of a mental disease. To estimate functional connectivity, we applied the phase lag index algorithm and the minimum spanning tree (MST) for the characterization of network topology. Group comparison revealed significant between-grou...
Source: Clinical EEG and Neuroscience - October 16, 2018 Category: Neuroscience Authors: Jonak K, Krukow P, Jonak KE, Grochowski C, Karakuła-Juchnowicz H Tags: Clin EEG Neurosci Source Type: research

Amplitude Instability of Somatosensory Evoked Potentials as an Indicator of Delayed Cerebral Ischemia in a Case of Subarachnoid Hemorrhage.
We describe a 55-year-old male patient with a subarachnoid hemorrhage (SAH) as a result of left middle cerebral artery (MCA) aneurysm rupture, who underwent continuous electroencephalogram (EEG) and somatosensory evoked potential (cEEG-SEP) monitoring that showed an unusual SEP trend pattern. EEG was continuously recorded, and SEPs following stimulation of median nerves were recorded every 50 minutes, with the amplitude and latency of the cortical components automatically trended. An increase in intracranial pressure required a left decompressive craniectomy. cEEG-SEP monitoring was started on day 7, which showed a prolong...
Source: Clinical EEG and Neuroscience - October 3, 2018 Category: Neuroscience Authors: Spalletti M, Orzalesi V, Carrai R, Bucciardini L, Cossu C, Scarpino M, Fainardi E, Marinoni M, Grippo A, Amantini A Tags: Clin EEG Neurosci Source Type: research

Altered Functional Connectivity of Alpha Rhythm in Obsessive-Compulsive Disorder During Rest.
Abstract Obsessive-compulsive disorder (OCD) is a common inheritable psychiatric disorder characteristic of repetitive thinking, imagination (obsession), and stereotyped behaviors (compulsive). To explore whether there is an alteration of brain functional connectivity (BFC) in patients with OCD during rest, electroencephalogram (EEG) data of healthy controls (HCs) and patients with OCD were collected during rest in both eyes-closed and eyes-open states. Synchronization likelihood and graph theory were applied to construct and analyze brain functional networks of patients with OCD and HCs. Patients with OCD showed ...
Source: Clinical EEG and Neuroscience - October 3, 2018 Category: Neuroscience Authors: Tan B, Liu Q, Wan C, Jin Z, Yang Y, Li L Tags: Clin EEG Neurosci Source Type: research

Analysis of Relation Between Electroclinical Features and Cerebrospinal Fluid Antibody Titers in Patients With anti-NMDAR Encephalitis.
CONCLUSION: The electroclinical features of patients with anti-NMDAR encephalitis were associated with gender and CSF antibody titers. PMID: 30246558 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - September 24, 2018 Category: Neuroscience Authors: Miao A, Du M, Wang L, Ge J, Lu H, Xu H, Liu H, Yu C, Wu C, Gao Y, Sun J, Shi Q, Wang X Tags: Clin EEG Neurosci Source Type: research

A Meta-Analysis of the Effect of Multisession Transcranial Direct Current Stimulation on Cognition in Dementia and Mild Cognitive Impairment.
Abstract There have been increasing efforts to investigate the effects of neuromodulation techniques, such as transcranial direct current stimulation (tDCS), on cognitive impairment in dementia and related conditions. In this systematic review and meta-analysis, we assessed the efficacy of multisession anodal tDCS compared with sham stimulation for improving global cognition and specific cognitive domains in both Alzheimer's disease and mild cognitive impairment. Eight articles meeting the criteria for inclusion in the meta-analysis were selected. Five studies used the Mini-Mental State Examination to examine mild...
Source: Clinical EEG and Neuroscience - September 19, 2018 Category: Neuroscience Authors: Inagawa T, Narita Z, Sugawara N, Maruo K, Stickley A, Yokoi Y, Sumiyoshi T Tags: Clin EEG Neurosci Source Type: research

Correlations Between Cognitive Aspects and Quantitative EEG in Adults With Epilepsy.
This study assessed cognition and its correlations with quantitative EEG coherence (QEEG) of patients with epilepsy. METHOD: Eighty PWE seen consecutively in the clinic and 40 normal subjects (NC) were assessed by neurological evaluation, Mini Mental State Examination, immediate and delayed recall of 10 simple figures, phonemic verbal fluency (FAS), category fluency test (VF animals), clock drawing, and QEEG. The mean global inter- and intrahemispheric coherences for the delta, theta, alpha, and beta bands were calculated. Cognitive functions and QEEG coherence of the PWE and the NC were compared, and logistic regress...
Source: Clinical EEG and Neuroscience - September 10, 2018 Category: Neuroscience Authors: Tedrus GM, Negreiros LM, Ballarim RS, Marques TA, Fonseca LC Tags: Clin EEG Neurosci Source Type: research

Resting EEG Measures of Brain Arousal in a Multisite Study of Major Depression.
GE Abstract Several studies have found upregulated brain arousal during 15-minute EEG recordings at rest in depressed patients. However, studies based on shorter EEG recording intervals are lacking. Here we aimed to compare measures of brain arousal obtained from 2-minute EEGs at rest under eyes-closed condition in depressed patients and healthy controls in a multisite project-Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC). We expected that depressed patients would show stable and elevated brain arousal relative to controls. Eighty-seven depressed patients and 36 h...
Source: Clinical EEG and Neuroscience - September 5, 2018 Category: Neuroscience Authors: Ulke C, Tenke CE, Kayser J, Sander C, Böttger D, Wong LYX, Alvarenga JE, Fava M, McGrath PJ, Deldin PJ, Mcinnis MG, Trivedi MH, Weissman MM, Pizzagalli DA, Hegerl U, Bruder GE Tags: Clin EEG Neurosci Source Type: research

Evoked Potentials Investigations of Deficit Versus Nondeficit Schizophrenia: EEG-MEG Preliminary Data.
This study investigated the evoked responses and the evoked magnetic fields to identify the neurophysiological deviations associated with the DS. Ten subjects were recruited for each group (Control, DS, and Nondeficit schizophrenia [NDS]). Subjects underwent magnetoencephalography (MEG) and electroencephalography (EEG) testing while listening to an oddball paradigm to generate the P300 as well as a paired click paradigm to generate the mid-latency auditory-evoked responses (MLAER) in a sensory gating paradigm. MEG-coherence source imaging (CSI) during P300 task revealed a significantly higher average coherence value in DS ...
Source: Clinical EEG and Neuroscience - September 3, 2018 Category: Neuroscience Authors: Boutros NN, Gjini K, Wang F, Bowyer SM Tags: Clin EEG Neurosci Source Type: research

Mesial Temporal Sclerosis in SCN1A-Related Epilepsy: Two Long-Term EEG Case Studies.
In conclusion, both patients suffered from a dual pathology syndrome with ( a) TLE related to MTS resulting most likely from recurrent febrile status in early childhood and ( b) Dravet syndrome, which is most likely the cause of the febrile convulsions leading to the MTS in these 2 patients. PMID: 30117335 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - August 17, 2018 Category: Neuroscience Authors: Tiefes AM, Hartlieb T, Tacke M, von Stülpnagel-Steinbeis C, Larsen LHG, Hao Q, Dahl HA, Neubauer BA, Gerstl L, Kudernatsch M, Kluger GJ, Borggraefe I Tags: Clin EEG Neurosci Source Type: research

Senile-Onset Subacute Sclerosing Panencephalitis, Presenting With Peculiar Findings.
In conclusion, we believe that neurologists for adults should consider SSPE in differential diagnosis, even in older patients with atypical presentations. PMID: 30099908 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - August 13, 2018 Category: Neuroscience Authors: Elmali AD, Simsekoglu R, Sahin E, Duman Ilki C, Uygun O, Coban O, Gurses C Tags: Clin EEG Neurosci Source Type: research

Reactivating the Dormant Motor Cortex After Spinal Cord Injury With EEG Neurofeedback: A Case Study With a Chronic, Complete C4 Patient.
uez J Abstract Chronic spinal cord injury (SCI) patients present poor motor cortex activation during movement attempts. The reactivation of this brain region can be beneficial for them, for instance, allowing them to use brain-machine interfaces for motor rehabilitation or restoration. These brain-machine interfacess generally use electroencephalography (EEG) to measure the cortical activation during the attempts of movement, quantifying it as the event-related desynchronization (ERD) of the alpha/mu rhythm. Based on previous evidence showing that higher tonic EEG alpha power is associated with higher ERD, we hypo...
Source: Clinical EEG and Neuroscience - August 7, 2018 Category: Neuroscience Authors: López-Larraz E, Escolano C, Montesano L, Minguez J Tags: Clin EEG Neurosci Source Type: research

Preliminary Evidence for Limbic-Frontal Hyperexcitability in Psychogenic Nonepileptic Seizure Patients.
CONCLUSIONS: The above findings are consistent with a disbalance between frontotemporal and posterior brain regions in this population with possible increased excitability in the FTRs. The data support the need for further investigations of the pathophysiology of PNES. The identification of a biomarker for PNES would not only provide for more informed therapeutic approaches, but it could also eliminate the stigma associated with the diagnosis of PNES. PMID: 30073861 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - August 3, 2018 Category: Neuroscience Authors: Boutros N, Kang SS, Uysal U, Urfy M, Thomas Z, Bowyer SM, Gustafson K Tags: Clin EEG Neurosci Source Type: research

P300 and Heart Rate Variability Recorded Simultaneously in Meditation.
Abstract Sympathetic activation is required for attention. Separate studies have shown that meditation ( a) improves attention and ( b) reduces sympathetic activity. The present study assessed attention with the P300 and sympathetic activity with heart rate variability (HRV). Forty-seven male subjects (group mean age ± SD, 21.6 ± 3.4 years) were assessed in 4 mental states: ( a) random thinking, ( b) nonmeditative focusing, ( c) meditative focusing, and ( d) defocused meditation. These were recorded on 4 consecutive days. HRV, respiration, and P300 event-related potentials (ERPs) were recorded before...
Source: Clinical EEG and Neuroscience - July 30, 2018 Category: Neuroscience Authors: Telles S, Singh D, Naveen KV, Pailoor S, Singh N, Pathak S Tags: Clin EEG Neurosci Source Type: research

Acute EEG Patterns Associated With Transient Ischemic Attack.
CONCLUSIONS: TIA, ischemic stroke, and healthy aging are each associated with distinct electrophysiological profiles. These preliminary findings suggest that acute EEG may be helpful in elucidating the pathophysiology and reversibility of TIA symptoms, and further exploration of the value of this unique functional brain data is encouraged. PMID: 30045636 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - July 25, 2018 Category: Neuroscience Authors: Rogers JM, Bechara J, Middleton S, Johnstone SJ Tags: Clin EEG Neurosci Source Type: research

High Frequencies in QEEG Are Related to the Level of Insight in Patients With Schizophrenia.
This study aimed to determine the correlation between resting state beta and gamma power in 23 patients with schizophrenia and insight. It was observed that as beta and gamma power measured via qualitative electroencephalography (qEEG) increased the level of insight decreased. Negative correlation was found in F3, C3, Cz for gamma activity and in F3 and C3 for beta activity. This finding indicates that resting state qEEG could be used to evaluate the level of insight in patients with schizophrenia. PMID: 29984595 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - July 1, 2018 Category: Neuroscience Authors: Arikan MK, Metin B, Metin SZ, Tülay EE, Tarhan N Tags: Clin EEG Neurosci Source Type: research

Early Intervention With Adrenocorticotropin for Acute Encephalopathy-Associated Epileptic Spasms: Report of Two Cases.
CONCLUSION: This report illustrates the potential efficacy of ACTH for a group of children with epileptic spasms after AESD. PMID: 29984606 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - July 1, 2018 Category: Neuroscience Authors: Yonemoto K, Ichimiya Y, Sanefuji M, Kaku N, Sakata A, Baba R, Yamashita F, Akamine S, Torio M, Ishizaki Y, Maehara Y, Sakai Y, Ohga S Tags: Clin EEG Neurosci Source Type: research

Predicting Clinical Gains and Side Effects of Stimulant Medication in Pediatric Attention-Deficit/Hyperactivity Disorder by Combining Measures From qEEG and ERPs in a Cued GO/NOGO Task.
CONCLUSION: Gains and side effects of stimulants in pediatric ADHD can be predicted with high accuracy by combining EEG spectra, ERPs, and behavior from baseline and single-dose tests. ClinicalTrials.gov identifier: NCT02695355. PMID: 29940782 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - June 1, 2018 Category: Neuroscience Authors: Ogrim G, Kropotov JD Tags: Clin EEG Neurosci Source Type: research

Multimodal Neuroimaging: Basic Concepts and Classification of Neuropsychiatric Diseases.
Abstract Neuroimaging techniques are widely used in neuroscience to visualize neural activity, to improve our understanding of brain mechanisms, and to identify biomarkers-especially for psychiatric diseases; however, each neuroimaging technique has several limitations. These limitations led to the development of multimodal neuroimaging (MN), which combines data obtained from multiple neuroimaging techniques, such as electroencephalography, functional magnetic resonance imaging, and yields more detailed information about brain dynamics. There are several types of MN, including visual inspection, data integration, ...
Source: Clinical EEG and Neuroscience - June 1, 2018 Category: Neuroscience Authors: Tulay EE, Metin B, Tarhan N, Arıkan MK Tags: Clin EEG Neurosci Source Type: research