Use of EEG for Predicting Treatment Response to Transcranial Magnetic Stimulation in Obsessive Compulsive Disorder.
In this study we assessed the predictive power of quantitative EEG (qEEG) for the treatment response to right frontal transcranial magnetic stimulation (TMS) in obsessive compulsive disorder (OCD) using a machine learning approach. Method. The study included 50 OCD patients (35 responsive to TMS, 15 nonresponsive) who were treated with right frontal low frequency stimulation and identified retrospectively from Uskudar Unversity, NPIstanbul Brain Hospital outpatient clinic. All patients were diagnosed with OCD according to the DSM-IV-TR and DSM-5 criteria. We first extracted pretreatment band powers for patients. To explore...
Source: Clinical EEG and Neuroscience - October 4, 2019 Category: Neuroscience Authors: Metin SZ, Balli Altuglu T, Metin B, Erguzel TT, Yigit S, Arıkan MK, Tarhan KN Tags: Clin EEG Neurosci Source Type: research

Individualized Neurofeedback Training May Help Achieve Long-Term Improvement of Working Memory in Children With ADHD.
Abstract Background. Children with attention deficit hyperactivity disorder (ADHD) may suffer from working memory deficits, which can adversely affect their academic performance. Neurofeedback training may enhance working memory and provide a solution to this problem. Aim. To investigate the effect of frequency-neurofeedback on working memory in children with ADHD and to check if the effect is long-lasting. Method. Forty-eight children with ADHD (aged 6-12 years) were randomly assigned either to a neurofeedback with training parameters chosen to take into account each child's peak alpha frequency (PAF) or to a wai...
Source: Clinical EEG and Neuroscience - October 3, 2019 Category: Neuroscience Authors: Dobrakowski P, Łebecka G Tags: Clin EEG Neurosci Source Type: research

Impact on Clinical Decision Making of Next-Generation Sequencing in Pediatric Epilepsy in a Tertiary Epilepsy Referral Center.
Conclusion. NGS epilepsy panels contribute to the diagnosis of pediatric epilepsy patients and may change their clinical management with regard to both preventing unnecessary and potentially harmful diagnostic procedures and management. Thus, the present data support the early implementation in order to adopt clinical management in selected cases and prevent further invasive investigations. Given the relatively small sample size and heterogeneous panels a larger prospective study with more homogeneous panels would be helpful to further determine the impact of NGS on clinical decision making. PMID: 31554424 [PubMed - a...
Source: Clinical EEG and Neuroscience - September 25, 2019 Category: Neuroscience Authors: Hoelz H, Herdl C, Gerstl L, Tacke M, Vill K, von Stuelpnagel C, Rost I, Hoertnagel K, Abicht A, Hollizeck S, Larsen LHG, Borggraefe I Tags: Clin EEG Neurosci Source Type: research

Brainwaves Oscillations as a Potential Biomarker for Major Depression Disorder Risk.
E, Manuel Olivares J, Spuch C Abstract Major depressive disorder (MDD) is a multidimensional disorder that is characterized by the presence of alterations in mood, cognitive capacity, sensorimotor, and homeostatic functions. Given that about half of the patients diagnosed with MDD do not respond to the various current treatments, new techniques are being sought to predict not only the course of the disease but also the characteristics that differentiate responders from non-responders. Using the electroencephalogram, a noninvasive and inexpensive tool, most studies have proposed that patients with MDD have some lat...
Source: Clinical EEG and Neuroscience - September 20, 2019 Category: Neuroscience Authors: Fernández-Palleiro P, Rivera-Baltanás T, Rodrigues-Amorim D, Fernández-Gil S, Del Carmen Vallejo-Curto M, Álvarez-Ariza M, López M, Rodriguez-Jamardo C, Luis Benavente J, de Las Heras E, Manuel Olivares J, Spuch C Tags: Clin EEG Neurosci Source Type: research

Phase Space Reconstruction of EEG Signals for Classification of ADHD and Control Adults.
This study focused on the utility of phase space reconstruction of brain signals to discriminate between ADHD and control adults. PMID: 31533446 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - September 19, 2019 Category: Neuroscience Authors: Kaur S, Singh S, Arun P, Kaur D, Bajaj M Tags: Clin EEG Neurosci Source Type: research

Time to Detection of the First Seizure in Patients With Nonconvulsive Status Epilepticus in the Neurological Intensive Care Unit.
In this study, we investigated the time required to record the first ictal event, and whether it could be correlated with some clinical or EEG parameters. Video-EEG recordings of patients who were followed up in our neurological intensive care unit were evaluated retrospectively. The EEG recordings of patients with NCSE were reviewed to determine the timing of the first seizure occurrence. Demographic data and EEG findings were obtained from patient charts and EEG reports. Possible correlations between the presence of periodic discharges (PD), Glasgow Coma Scale (GCS) score and early seizure detection (defined as a seizure...
Source: Clinical EEG and Neuroscience - September 19, 2019 Category: Neuroscience Authors: Dericioglu N, Arsava EM, Topcuoglu MA Tags: Clin EEG Neurosci Source Type: research

Quantitative and Qualitative EEG as a Prediction Tool for Outcome and Complications in Acute Stroke Patients.
Abstract Currently, the relevance of EEG measurements in acute stroke patients is considered low in clinical practice. However, recent studies on the predictive value of EEG measurements after stroke for various outcomes may increase the role of EEG in patients with stroke. We aimed to review the current literature on the utility of EEG measurements after stroke as a tool to predict outcome and complications, focusing on studies in which the EEG measurement was performed in the acute phase after the event and in which long-term outcome measures were reported. In our literature review, we identified 4 different out...
Source: Clinical EEG and Neuroscience - September 19, 2019 Category: Neuroscience Authors: Doerrfuss JI, Kilic T, Ahmadi M, Holtkamp M, Weber JE Tags: Clin EEG Neurosci Source Type: research

The Morphology of Somatosensory Evoked Potentials During Middle Cerebral Artery Aneurysm Clipping (MoSAC): A Pilot Study.
Abstract Somatosensory evoked potential (SEP) monitoring is a standard tool during clipping of aneurysms of the middle cerebral artery (MCA), and the parameter used to detect a state of cortical ischemia is amplitude. We think that the sensitivity of SEP can however be improved by using other parameters. Our study moves in this direction via SEP morphology. In this pilot preliminary study, involving a small sample without postoperative neurological deficit, we aimed at investigating the value of SEP morphology (in the 15- to 35-ms time frame), in comparison with SEP amplitude (N20 peak-to-peak), as a measure of se...
Source: Clinical EEG and Neuroscience - September 12, 2019 Category: Neuroscience Authors: Tecchio F, Cecconi F, Colamartino E, Padalino M, Valci L, Reinert M Tags: Clin EEG Neurosci Source Type: research

Standardization and Personalized Medicine Using Quantitative EEG in Clinical Settings.
Abstract Two major trends have been dominant in health care in recent years. First, there is a growing consensus that standardization of health care procedures and methods can result in improved effectiveness and safety of treatments. Second, there is increased interest in "personalized medicine," which refers to the tailoring of treatments to individual patients. Here I discuss how these trends apply to the field of quantitative EEG (qEEG), where de-artifacted resting state EEGs of individuals are compared with a normative database in order to assess clinically meaningful deviations, which can be used f...
Source: Clinical EEG and Neuroscience - September 11, 2019 Category: Neuroscience Authors: Keizer AW Tags: Clin EEG Neurosci Source Type: research

Electroencephalogram and Clinical Characteristics and Correlations in Patients With Anti-N-Methyl-d-Aspartate Receptor Encephalitis.
Abstract Objective. Electroencephalogram (EEG) is a sensitive method for evaluation of anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis. The aim was to investigate the EEG and clinical features and correlations in patients with anti-NMDAR encephalitis. Methods. Anti-NMDAR encephalitis patients (n = 98) with at least 1 EEG recording in our hospital were recruited between January 2012 and October 2017. We reviewed and analyzed the EEG and clinical data. Results. In our cohorts, 79 patients underwent EEG in the disease acute stage, and 39 in the recovery stage. Of the 79 patients, 70 (88.6%) EEG recording...
Source: Clinical EEG and Neuroscience - August 26, 2019 Category: Neuroscience Authors: Lin N, Huang Y, Jin L, Lu Q, Liu Q, Zhou X, Guan H Tags: Clin EEG Neurosci Source Type: research

Serious Games as Potential Therapies: A Validation Study of a Neurofeedback Game.
In conclusion, we found only marginal evidence for the proposed claims stated in the manual of the game. Our research emphasizes that it is crucial to validate the claims that serious games make, especially before implementing them in the clinic or as therapeutic devices. PMID: 31423818 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - August 18, 2019 Category: Neuroscience Authors: Coenen F, Scheepers FE, Palmen SJM, de Jonge MV, Oranje B Tags: Clin EEG Neurosci Source Type: research

Gamma-Band Auditory Steady-State Response as a Neurophysiological Marker for Excitation and Inhibition Balance: A Review for Understanding Schizophrenia and Other Neuropsychiatric Disorders.
Abstract Altered gamma oscillations have attracted considerable attention as an index of the excitation/inhibition (E/I) imbalance in schizophrenia and other neuropsychiatric disorders. The auditory steady-state response (ASSR) has been the most robust probe of abnormal gamma oscillatory dynamics in schizophrenia. Here, we review recent ASSR studies in patients with schizophrenia and other neuropsychiatric disorders. Preclinical ASSR research, which has contributed to the elucidation of the underlying pathophysiology of these diseases, is also discussed. The developmental trajectory of the ASSR has been explored a...
Source: Clinical EEG and Neuroscience - August 12, 2019 Category: Neuroscience Authors: Tada M, Kirihara K, Koshiyama D, Fujioka M, Usui K, Uka T, Komatsu M, Kunii N, Araki T, Kasai K Tags: Clin EEG Neurosci Source Type: research

Deficit Effect Sizes and Correlations of Auditory Event-Related Potentials at First Hospitalization in the Schizophrenia Spectrum.
We examined effect sizes of, and correlations between, N1, P2, P3, and MMN in 106 FESz and 114 matched psychiatrically well controls to determine which ERPs maximally differentiated groups, and whether late sensory/perceptual deficits (N1, P2) affected preattentive memory (MMN) and conscious attention (P3). Furthermore, we compared hallucinators and nonhallucinators within FESz. Participants completed 1 of 3 oddball tasks, silently counting target tones among standard tones. Sixty-seven FESz and 72 matched participants also completed pitch-deviant MMN testing. Measures were z-scored from task appropriate controls before me...
Source: Clinical EEG and Neuroscience - August 7, 2019 Category: Neuroscience Authors: Salisbury DF, Kohler J, Shenton ME, McCarley RW Tags: Clin EEG Neurosci Source Type: research

Deficit Versus Nondeficit Schizophrenia: An MEG-EEG Investigation of Resting State and Source Coherence-Preliminary Data.
This study investigated the magneto- and electroencephalography (MEG and EEG, respectively) resting state to identify the deviations closely associated with the deficit syndrome (DS) in schizophrenia patients. Ten subjects in each group (control, DS, and nondeficit schizophrenia [NDS]) were included. Subjects underwent MEG-EEG recordings during a resting state condition. MEG coherence source imaging (CSI) in source space and spectral analysis in sensor space were performed. Significant differences were found between the 2 patient groups: (1) MEG and EEG spectral analysis showed significantly higher power at low frequencies...
Source: Clinical EEG and Neuroscience - August 4, 2019 Category: Neuroscience Authors: Gjini K, Bowyer SM, Wang F, Boutros NN Tags: Clin EEG Neurosci Source Type: research

Electroencephalogram Characteristics in Critical Ill Patients Before Cardiac Arrest: A Case Series.
Abstract Background/Objectives. To illustrate characteristic electroencephalogram (EEG) features in patients prior to their first cardiac arrest. Methods. We identified 15 patients who suffered cardiac arrest during continuous EEG at our institution from June 2016 to June 2019. Eight patients were excluded due to co-administration of intravenous anesthetics (which may confound EEG) or if they had a previous prolonged cardiac arrest (>5 minutes) during the same hospitalization. We collected background information, analyzed the time span and vital signs between the initial background change and cardiac arrest. Re...
Source: Clinical EEG and Neuroscience - July 29, 2019 Category: Neuroscience Authors: Xu J, Mohamed W, Basha MM, Zutshi D Tags: Clin EEG Neurosci Source Type: research

A New Method of Diagnosing Attention-Deficit Hyperactivity Disorder in Male Patients by Quantitative EEG Analysis.
In this study, we attempted to develop a new method for differentiating between male with and without ADHD by analyzing EEG features. Thirty boys with ADHD combined type (aged 8 years 5 months ± 1 year 11 months) and 30 age-matched controls (aged 8 years 5 months ± 1 year 8 months) were enrolled in this study. A classification analysis-based approach comprising training and classification phases was developed for classifying each subject's EEG features as ADHD or non-ADHD. Eight crucial feature descriptors were selected and ranked based on the t test. Compared with TBR in our study, the developed method had a...
Source: Clinical EEG and Neuroscience - July 19, 2019 Category: Neuroscience Authors: Chang MY, Ouyang CS, Chiang CT, Yang RC, Wu RC, Wu HC, Lin LC Tags: Clin EEG Neurosci Source Type: research

Probing the "Default Network Interference Hypothesis" With EEG: An RDoC Approach Focused on Attention.
Probing the "Default Network Interference Hypothesis" With EEG: An RDoC Approach Focused on Attention. Clin EEG Neurosci. 2019 Jul 19;:1550059419864461 Authors: Gerrits B, Vollebregt MA, Olbrich S, van Dijk H, Palmer D, Gordon E, Pascual-Marqui R, Kessels RPC, Arns M Abstract Studies have shown that specific networks (default mode network [DMN] and task positive network [TPN]) activate in an anticorrelated manner when sustaining attention. Related EEG studies are scarce and often lack behavioral validation. We performed independent component analysis (ICA) across different frequencies (sourc...
Source: Clinical EEG and Neuroscience - July 19, 2019 Category: Neuroscience Authors: Gerrits B, Vollebregt MA, Olbrich S, van Dijk H, Palmer D, Gordon E, Pascual-Marqui R, Kessels RPC, Arns M Tags: Clin EEG Neurosci Source Type: research

Transcranial Direct Current Stimulation for Treatment-Resistant Major Depression: A Double-Blind Randomized Sham-Controlled Trial.
Abstract In the current study, we tried to evaluate the effect of transcranial direct current stimulation (tDCS) on treatment-resistant major depression. We carried out a double-blind randomized sham-controlled trial was conducted in University Hospitals. Individuals with less than 50% decrease in the intensity of depression after 8 weeks of treatment with selective serotonin reuptake inhibitors were recruited. Thirty patients (16 women) with a mean (SD) age of 47.2 (12.0) years were randomly allocated to 2 groups. For the active group we administered 2-mA stimulation 20 minutes for each session, with 30 seconds r...
Source: Clinical EEG and Neuroscience - July 15, 2019 Category: Neuroscience Authors: Sharafi E, Taghva A, Arbabi M, Dadarkhah A, Ghaderi J Tags: Clin EEG Neurosci Source Type: research

Predictive Value of Slow and Fast EEG Oscillations for Methylphenidate Response in ADHD.
Abstract Attention-deficit/hyperactivity disorder (ADHD) is the most common neurodevelopmental disorder and is characterized by symptoms of inattention and/or hyperactivity and impulsivity. In the current study, we obtained quantitative EEG (QEEG) recordings of 51 children aged between 6 and 12 years before the initiation of methylphenidate treatment. The relationship between changes in the scores of ADHD symptoms and initial QEEG features (power/power ratios values) were assessed. In addition, the children were classified as responder and nonresponder according to the ratio of their response to the medication (&g...
Source: Clinical EEG and Neuroscience - July 15, 2019 Category: Neuroscience Authors: Sari Gokten E, Tulay EE, Beser B, Elagoz Yuksel M, Arikan K, Tarhan N, Metin B Tags: Clin EEG Neurosci Source Type: research

The "MS-ROM/IFAST" Model, a Novel Parallel Nonlinear EEG Analysis Technique, Distinguishes ASD Subjects From Children Affected With Other Neuropsychiatric Disorders With High Degree of Accuracy.
Conclusions. These results confirm the possibility of an early automatic autism detection based on standard EEG. PMID: 31296052 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - July 11, 2019 Category: Neuroscience Authors: Grossi E, Buscema M, Della Torre F, Swatzyna RJ Tags: Clin EEG Neurosci Source Type: research

Borderline Personality and Bipolar Disorders Cannot Be Differentiated Electrophysiologically.
Conclusion. The findings suggested that these 2 clinical entities are biologically similar; however, further research should be performed to explain the basis clinical differences between the 2 disorders. PMID: 31282204 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - July 8, 2019 Category: Neuroscience Authors: Arikan MK, Metin B, Gunver MG, Tarhan N Tags: Clin EEG Neurosci Source Type: research

Investigation of Generalized EEG Paroxysms Accompanying Focal Epilepsies.
kan B Abstract Interictal focal EEG features were frequently observed in generalized, epilepsies, but there is limited information about interictal, epileptiform/nonepileptiform generalized paroxysms in focal epilepsies. We aimed to report the frequency and associated factors of generalized EEG discharges in focal epilepsy with unknown cause (FEUC) and mesial, temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). A total of 200 patients (FEUC in 90 patients; MTLE-HS in 110 patients) were included. Generalized epileptiform (spike/sharp waves simultaneously in all regions) and nonspecific generalized discharg...
Source: Clinical EEG and Neuroscience - June 28, 2019 Category: Neuroscience Authors: Atalar AÇ, Vanlı-Yavuz EN, Yılmaz E, Bebek N, Baykan B Tags: Clin EEG Neurosci Source Type: research

Relationship of Metacognition and Insight to Neural Synchronization and Cognitive Function in Early Phase Psychosis.
Abstract Metacognition is the process of thinking about one's own mental states. It involves a range of faculties that allow an individual to integrate information and form understanding of self and others, and use this understanding to respond to life challenges. Clinical insight is the awareness of one's mental illness, its consequences, and the need for treatment. Persons with psychotic disorders show impaired metacognition and insight, but the neurobiological bases for these impairments are not well characterized. We hypothesized that metacognition and insight may depend on capacity of neural circuits to synch...
Source: Clinical EEG and Neuroscience - June 26, 2019 Category: Neuroscience Authors: Leonhardt BL, Vohs JL, Bartolomeo LA, Visco A, Hetrick WP, Bolbecker AR, Breier A, Lysaker PH, O'Donnell BF Tags: Clin EEG Neurosci Source Type: research

EEG Findings in Posterior Reversible Encephalopathy Syndrome.
Conclusion. EEG findings in PRES are diverse, with no specific or even predominant pattern, based on this small sample size. PMID: 31215229 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - June 19, 2019 Category: Neuroscience Authors: Murray K, Amin U, Maciver S, Benbadis SR Tags: Clin EEG Neurosci Source Type: research

Evaluation of Neurofeedback for Posttraumatic Stress Disorder Related to Refugee Experiences Using Self-Report and Cognitive ERP Measures.
CONCLUSIONS: These preliminary observations are consistent with a possible benefit of neurofeedback for remediating PTSD. This may be achieved at least partially by an improvement in cognitive control. Further confirmation of the effectiveness of the treatment now requires a randomized controlled trial that considers issues such as placebo response, nonspecific therapist effects, and duration of treatment. PMID: 31132893 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - May 27, 2019 Category: Neuroscience Authors: Askovic M, Watters AJ, Coello M, Aroche J, Harris AWF, Kropotov J Tags: Clin EEG Neurosci Source Type: research

Resting State EEG Characteristics During Sedation With Midazolam or Propofol in Older Subjects.
CONCLUSION: Despite the different levels of light sedation with midazolam and propofol, similar changes in power were found. Functional connectivity and network topology showed differences between midazolam and propofol sedation. Future research should establish if these differences are caused by the different levels of sedation or the mechanism of action of these agents. PMID: 31106583 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - May 20, 2019 Category: Neuroscience Authors: Numan T, van Dellen E, Vleggaar FP, van Vlieberghe P, Stam CJ, Slooter AJC Tags: Clin EEG Neurosci Source Type: research

Event-Related Potential Analysis of ADHD and Control Adults During a Sustained Attention Task.
CONCLUSIONS: The differences in texture features obtained from t-f images of ERPs point toward altered information processing in adults with ADHD during a cognitive task. Findings of reduction in N1, N2, and P3 components highlight deficits of early sensory processing, stimulus categorization, and attentional resources, respectively, in adults with ADHD. PMID: 30997836 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - April 18, 2019 Category: Neuroscience Authors: Kaur S, Singh S, Arun P, Kaur D, Bajaj M Tags: Clin EEG Neurosci Source Type: research

Visual P300 Mind-Speller Brain-Computer Interfaces: A Walk Through the Recent Developments With Special Focus on Classification Algorithms.
This article is organized with a brief introduction to P300, concepts of visual P300 mind-spellers, the survey of literature with special focus on classification algorithms, followed by the discussion of various challenges and future directions. PMID: 30997842 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - April 18, 2019 Category: Neuroscience Authors: Philip JT, George ST Tags: Clin EEG Neurosci Source Type: research

Treatment of Medial Medullary Infarction Using a Novel iNems Training: A Case Report and Literature Review.
CONCLUSIONS: The newly developed iNems could prove a novel, useful tool for neurorehabilitation considering that both behavioral and neurophysiological changes were observed in our case. PMID: 30955363 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - April 7, 2019 Category: Neuroscience Authors: Kodama T, Katayama O, Nakano H, Ueda T, Murata S Tags: Clin EEG Neurosci Source Type: research

Continuous Electroencephalogram as a Biomarker of Disease Progression and Severity in Herpes Simplex Virus-1 Encephalitis.
We report the case of a patient with HSE who was monitored on CEEG and propose that CEEG can be used as a marker for progression of disease and thus may prompt escalation in therapy. While imaging studies may confirm spread of disease, using CEEG may prevent the delay of treatment and lead to more rapid therapy in cases of refractory HSE. PMID: 30873853 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - March 15, 2019 Category: Neuroscience Authors: Baten A, Desai M, Melo-Bicchi M, Gutierrez C Tags: Clin EEG Neurosci Source Type: research

Sex as a Moderating Factor in the Relationship Between Hippocampal Volume and Sensory Gating in Patients With Schizophrenia.
Abstract Building on the knowledge of sex differences in auditory sensory gating in schizophrenia and hippocampal involvement in sensory gating, this study aimed to investigate sex as a potential moderator of the association between hippocampal volume and P50 in schizophrenia. Auditory P50 gating and hippocampal volume were measured in 16 male and 15 female patients with schizophrenia. The correlations between hippocampal volume and P50 were analyzed in males and females separately, corrected for potential confounders, including age, duration of illness, and antipsychotic medication. Different associative patterns...
Source: Clinical EEG and Neuroscience - March 12, 2019 Category: Neuroscience Authors: Huang WL, Liu CY, Liu HM, Liu CM, Hsieh MH Tags: Clin EEG Neurosci Source Type: research

Atypical SREDA During Wakefulness, NREM and REM Sleep in a Young Teenager: A Diagnostic Challenge.
We report a case of atypical SREDA in a child that may have occurred in wakefulness, non-rapid eye movement (NREM) sleep, and REM sleep. This finding was initially misdiagnosed as epilepsy. Inpatient video-EEG demonstrated that during periods of SREDA in quiet wakefulness the patient did not have any signs or symptoms with the SREDA pattern; SREDA abated whenever the patient was alerted or if he spontaneously initiated some activities. SREDA with same morphology was noted in NREM and REM sleep. The patient had no true epileptogenic abnormalities and hence antiepileptic medication was discontinued and stopped uneventfully. ...
Source: Clinical EEG and Neuroscience - January 23, 2019 Category: Neuroscience Authors: Gil L, Moosa A, Gupta A Tags: Clin EEG Neurosci Source Type: research

Abnormalities of Alpha Activity in Frontocentral Region of the Brain as a Biomarker to Diagnose Adolescents With Bipolar Disorder.
CONCLUSION: Based on BD symptoms, especially inattention, increased alpha power is a rational finding which is associated with thalamus dysfunction. Thus, it seems that EEG alpha oscillation is the main source of abnormality in BD. Furthermore, EEG slowing in the depressive episode is related to inhibition of electrical activity and reduced cognitive functions. PMID: 30642197 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - January 14, 2019 Category: Neuroscience Authors: Khaleghi A, Mohammadi MR, Moeini M, Zarafshan H, Fadaei Fooladi M Tags: Clin EEG Neurosci Source Type: research

The Three Nociceptive Responses of the Orbicularis Oculi Reflex in Alzheimer's Disease: State of the Evidence and Meta-analysis.
Abstract There is an emerging belief that electrically elicited blink reflexes (BR) may distinguish Alzheimer's disease (AD) from other disorders characterized by memory dysfunction. To qualitatively and quantitatively distinguish the effects that electrical stimulation has over the blink reflex (eBR) recorded from patients with AD and healthy controls (HCs), we did a systematic review of the literature, and conducted a meta-analysis. Following our selected criteria, 94 AD patients and 97 HCs were identified from articles published in English between 1950 and 2017. Although the 3 responses (R1, R2 and R3) of the e...
Source: Clinical EEG and Neuroscience - January 14, 2019 Category: Neuroscience Authors: Leon-Ariza JS, Prada DG, Leon-Ariza DS, Castillo C, Leon-Sarmiento FE Tags: Clin EEG Neurosci Source Type: research

Binomial Logistic Regression and Artificial Neural Network Methods to Classify Opioid-Dependent Subjects and Control Group Using Quantitative EEG Power Measures.
In this study, we introduce the 2 aforementioned approaches in order to generate a model dichotomizing 75 opioid-dependent patients and 59 control subjects from each other. Quantitative electroencephalography (QEEG) absolute power value of each electrode were calculated for 4 consecutive frequency bands namely delta, theta, alpha, and beta with the frequencies, 0.5 to 4, 4 to 8, 8 to 12, and 12 to 20 Hz, respectively. Significant independent variables contributing to the classification were underlined in LR while a feature selection (FS) method, genetic algorithm, is being applied to the ANN model to reveal more informativ...
Source: Clinical EEG and Neuroscience - January 14, 2019 Category: Neuroscience Authors: Erguzel TT, Noyan CO, Eryilmaz G, Ünsalver BÖ, Cebi M, Tas C, Dilbaz N, Tarhan N Tags: Clin EEG Neurosci Source Type: research

Measuring Treatment Response in Pharmacological and Lifestyle Interventions Using Electroencephalography in ADHD: A Review.
Abstract Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity, and/or impulsivity with associations to short- and long-term aversive life events. The exact etiology of the disorder is still unknown. ADHD is heterogeneous in symptomology and a single consistent, reliable biomarker has not been found. Quantitative electroencephalography (EEG) has been proposed as a potential way to differentiate those with ADHD from typically developing controls; however, the data on the diagnostic utility of this approach have been variable. Quantitative EEG ha...
Source: Clinical EEG and Neuroscience - January 9, 2019 Category: Neuroscience Authors: Kirkland AE, Holton KF Tags: Clin EEG Neurosci Source Type: research

Entropy-Based Quantitative Electroencephalogram Analysis for Diagnosing Attention-Deficit Hyperactivity Disorder in Girls.
This study detailed the development of a method based on approximate entropy (ApEn) analysis of EEG to compare ADHD and control groups. Differences between ADHD presentation in boys and girls indicate the necessity of separate investigations. This study enrolled 30 girls with ADHD and 30 age-matched controls. The results revealed significantly higher ApEn values in most brain areas in the control group than in the ADHD group. Compared with TBR-related feature descriptors, ApEn-related feature descriptors can produce the higher average true positive rate (0.846), average true negative rate (0.814), average accuracy (0.817),...
Source: Clinical EEG and Neuroscience - November 29, 2018 Category: Neuroscience Authors: Chow JC, Ouyang CS, Tsai CL, Chiang CT, Yang RC, Wu RC, Wu HC, Lin LC Tags: Clin EEG Neurosci Source Type: research

Multifeature Mismatch Negativity in Patients With Posttraumatic Stress Disorder.
CONCLUSIONS: Choice of the stimulus protocol might be an important factor to explain inconsistent results in previous research. Differences in the auditory context between stimulus protocols and deficits in the formation of larger (auditory) contexts in PTSD might account for the results. SIGNIFICANCE: This study adds to the small number of studies on PTSD and MMN and revealed valuable information to guide future, related studies. PMID: 30497295 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - November 29, 2018 Category: Neuroscience Authors: Löw A, Frey JD, Gorzka R, Engers A, Wendt M, Höllmer H, Jacobsen T Tags: Clin EEG Neurosci Source Type: research

Event-Related Potentials Are Associated With Unexpected Gain and Loss: Using a Gambling Paradigm.
CONCLUSION: These results indicate that the paradigm is suitable to evoke specific patterns of reward-related electrophysiological responses. The wavelet analysis showed that electroencephalography frequency variations depended on the amount of gains/losses. SIGNIFICANCE: This gambling paradigm is appropriate to measure aspects of feedback processing and could help analyze disease-specific alterations of the reward system in patients. PMID: 30477341 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - November 27, 2018 Category: Neuroscience Authors: Krause D, Jobst A, Langemak SM, Keeser D, Chrobok AI, Langgartner S, Adorjan K, Gertzen M, Pogarell O, Karch S Tags: Clin EEG Neurosci Source Type: research

Auditory P300 as a Neurophysiological Correlate of Symptomatic Improvement by Transcranial Direct Current Stimulation in Patients With Schizophrenia: A Pilot Study.
CONCLUSIONS: Although this pilot study is limited by the small sample size and lack of a sham control, the results suggest that auditory P300 may be a putative marker reflecting the effect of tDCS on the positive and negative symptoms of schizophrenia. PMID: 30474393 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - November 25, 2018 Category: Neuroscience Authors: Kim M, Lee TH, Hwang WJ, Lee TY, Kwon JS Tags: Clin EEG Neurosci Source Type: research

EEG Neurofeedback Training in Children With Attention Deficit/Hyperactivity Disorder: A Cognitive and Behavioral Outcome Study.
CONCLUSION: The present study suggests that NFT is an effective method to enhance cognitive deficits and helps reduce ADHD symptoms and behavior problems. Consequently, academic performance was found to be improved in children with ADHD. Improvement in ADHD symptoms induced by NFT were maintained at 6-month follow-up in children with ADHD. PMID: 30453757 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - November 20, 2018 Category: Neuroscience Authors: Shereena EA, Gupta RK, Bennett CN, Sagar KJV, Rajeswaran J Tags: Clin EEG Neurosci Source Type: research

Association Between Positive Occipital Sharp Transients of Sleep and Lambda Waves.
Abstract Positive occipital sharp transients of sleep (POSTS) and lambda waves have similar morphology and location. We studied a possible association between these 2 normal EEG patterns. We reviewed a series of consecutive unselected ambulatory EEGs during a 3-month period (October 16, 2017 to January 19, 2018) and identified records with POSTS and records with lambda waves. Statistical analysis was performed using a chi-square test. A total of 140 ambulatory EEGs were reviewed. Duration of EEGs ranged from 24 to 168 hours (mean 76 hours). The population was 34% males, with ages ranging from 3 to 93 years (mean 4...
Source: Clinical EEG and Neuroscience - November 14, 2018 Category: Neuroscience Authors: Amin U, Sullivan L, Trudeau P, Benbadis SR Tags: Clin EEG Neurosci Source Type: research

EEG Resting-State Networks Responsible for Gait Disturbance Features in Idiopathic Normal Pressure Hydrocephalus.
In this study, using exact low-resolution brain electromagnetic tomography-independent component analysis (eLORETA-ICA) with electroencephalography (EEG) data, we assessed activities of five EEG resting-state networks (EEG-RSNs) in 58 iNPH patients before and after drainage of CSF by lumbar puncture (CSF tapping). In addition, we assessed correlations of changes in these five EEG-RSNs activities with CSF tapping-induced changes in iNPH symptoms. The results reveal that compared with 80 healthy controls, iNPH patients had significantly decreased activities in the occipital alpha rhythm, visual perception network, and self-r...
Source: Clinical EEG and Neuroscience - November 11, 2018 Category: Neuroscience Authors: Aoki Y, Kazui H, Pascual-Marqui RD, Ishii R, Yoshiyama K, Kanemoto H, Suzuki Y, Sato S, Azuma S, Suehiro T, Matsumoto T, Hata M, Canuet L, Iwase M, Ikeda M Tags: Clin EEG Neurosci Source Type: research

Quantitative and Qualitative Comparison of EEG-Based Neural Network Organization in Two Schizophrenia Groups Differing in the Duration of Illness and Disease Burden: Graph Analysis With Application of the Minimum Spanning Tree.
Abstract The aim of this study was to compare neural network topology of 30 patients with first episode schizophrenia (FES) and 30 multiepisode schizophrenia (mean number of psychotic relapses =4 years, duration of illness>5 years) patients, who were assessed with graph theory methods. This comparison was designed to identify network differences, which might be assigned to the burden of a mental disease. To estimate functional connectivity, we applied the phase lag index algorithm and the minimum spanning tree (MST) for the characterization of network topology. Group comparison revealed significant between-grou...
Source: Clinical EEG and Neuroscience - October 16, 2018 Category: Neuroscience Authors: Jonak K, Krukow P, Jonak KE, Grochowski C, Karakuła-Juchnowicz H Tags: Clin EEG Neurosci Source Type: research

Amplitude Instability of Somatosensory Evoked Potentials as an Indicator of Delayed Cerebral Ischemia in a Case of Subarachnoid Hemorrhage.
We describe a 55-year-old male patient with a subarachnoid hemorrhage (SAH) as a result of left middle cerebral artery (MCA) aneurysm rupture, who underwent continuous electroencephalogram (EEG) and somatosensory evoked potential (cEEG-SEP) monitoring that showed an unusual SEP trend pattern. EEG was continuously recorded, and SEPs following stimulation of median nerves were recorded every 50 minutes, with the amplitude and latency of the cortical components automatically trended. An increase in intracranial pressure required a left decompressive craniectomy. cEEG-SEP monitoring was started on day 7, which showed a prolong...
Source: Clinical EEG and Neuroscience - October 3, 2018 Category: Neuroscience Authors: Spalletti M, Orzalesi V, Carrai R, Bucciardini L, Cossu C, Scarpino M, Fainardi E, Marinoni M, Grippo A, Amantini A Tags: Clin EEG Neurosci Source Type: research

Altered Functional Connectivity of Alpha Rhythm in Obsessive-Compulsive Disorder During Rest.
Abstract Obsessive-compulsive disorder (OCD) is a common inheritable psychiatric disorder characteristic of repetitive thinking, imagination (obsession), and stereotyped behaviors (compulsive). To explore whether there is an alteration of brain functional connectivity (BFC) in patients with OCD during rest, electroencephalogram (EEG) data of healthy controls (HCs) and patients with OCD were collected during rest in both eyes-closed and eyes-open states. Synchronization likelihood and graph theory were applied to construct and analyze brain functional networks of patients with OCD and HCs. Patients with OCD showed ...
Source: Clinical EEG and Neuroscience - October 3, 2018 Category: Neuroscience Authors: Tan B, Liu Q, Wan C, Jin Z, Yang Y, Li L Tags: Clin EEG Neurosci Source Type: research

Analysis of Relation Between Electroclinical Features and Cerebrospinal Fluid Antibody Titers in Patients With anti-NMDAR Encephalitis.
CONCLUSION: The electroclinical features of patients with anti-NMDAR encephalitis were associated with gender and CSF antibody titers. PMID: 30246558 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - September 24, 2018 Category: Neuroscience Authors: Miao A, Du M, Wang L, Ge J, Lu H, Xu H, Liu H, Yu C, Wu C, Gao Y, Sun J, Shi Q, Wang X Tags: Clin EEG Neurosci Source Type: research

A Meta-Analysis of the Effect of Multisession Transcranial Direct Current Stimulation on Cognition in Dementia and Mild Cognitive Impairment.
Abstract There have been increasing efforts to investigate the effects of neuromodulation techniques, such as transcranial direct current stimulation (tDCS), on cognitive impairment in dementia and related conditions. In this systematic review and meta-analysis, we assessed the efficacy of multisession anodal tDCS compared with sham stimulation for improving global cognition and specific cognitive domains in both Alzheimer's disease and mild cognitive impairment. Eight articles meeting the criteria for inclusion in the meta-analysis were selected. Five studies used the Mini-Mental State Examination to examine mild...
Source: Clinical EEG and Neuroscience - September 19, 2018 Category: Neuroscience Authors: Inagawa T, Narita Z, Sugawara N, Maruo K, Stickley A, Yokoi Y, Sumiyoshi T Tags: Clin EEG Neurosci Source Type: research

Correlations Between Cognitive Aspects and Quantitative EEG in Adults With Epilepsy.
This study assessed cognition and its correlations with quantitative EEG coherence (QEEG) of patients with epilepsy. METHOD: Eighty PWE seen consecutively in the clinic and 40 normal subjects (NC) were assessed by neurological evaluation, Mini Mental State Examination, immediate and delayed recall of 10 simple figures, phonemic verbal fluency (FAS), category fluency test (VF animals), clock drawing, and QEEG. The mean global inter- and intrahemispheric coherences for the delta, theta, alpha, and beta bands were calculated. Cognitive functions and QEEG coherence of the PWE and the NC were compared, and logistic regress...
Source: Clinical EEG and Neuroscience - September 10, 2018 Category: Neuroscience Authors: Tedrus GM, Negreiros LM, Ballarim RS, Marques TA, Fonseca LC Tags: Clin EEG Neurosci Source Type: research

Resting EEG Measures of Brain Arousal in a Multisite Study of Major Depression.
GE Abstract Several studies have found upregulated brain arousal during 15-minute EEG recordings at rest in depressed patients. However, studies based on shorter EEG recording intervals are lacking. Here we aimed to compare measures of brain arousal obtained from 2-minute EEGs at rest under eyes-closed condition in depressed patients and healthy controls in a multisite project-Establishing Moderators and Biosignatures of Antidepressant Response for Clinical Care (EMBARC). We expected that depressed patients would show stable and elevated brain arousal relative to controls. Eighty-seven depressed patients and 36 h...
Source: Clinical EEG and Neuroscience - September 5, 2018 Category: Neuroscience Authors: Ulke C, Tenke CE, Kayser J, Sander C, Böttger D, Wong LYX, Alvarenga JE, Fava M, McGrath PJ, Deldin PJ, Mcinnis MG, Trivedi MH, Weissman MM, Pizzagalli DA, Hegerl U, Bruder GE Tags: Clin EEG Neurosci Source Type: research