An Evaluation of the Channel Effect on Detecting the Preictal Stage in Patients With Epilepsy.
This study is an evaluation of the performances of EEG signals, obtained from different channels in the detection processes of epileptic stages, in epileptic individuals. In particular, it aimed to analyze the separation levels of preictal periods from other periods and to evaluate the effects of the electrode selection on seizure prediction studies. The EEG signals belong to 14 epileptic patients. A feature set was formed for each patient using 20 features widely used in epilepsy studies. The number of features was decreased to 8 using principal component analysis. The reduced feature set was divided into testing and trai...
Source: Clinical EEG and Neuroscience - October 21, 2020 Category: Neuroscience Authors: Bergil E, Bozkurt MR, Oral C Tags: Clin EEG Neurosci Source Type: research

Alterations of Resting EEG in Hallucinating and Nonhallucinating Schizophrenia Patients.
This study assessed changes in frequency bands (delta, theta, alpha, beta) of resting EEG taken from hallucinating patients (n = 12), nonhallucinating patients (n = 11), and healthy controls (n = 12). Delta and theta activity were unaffected by AHs but differed between patients with schizophrenia and healthy controls. Alpha activity was affected by AHs: nonhallucinators had more alpha activity than hallucinators and healthy controls. Additionally, beta activity was inversely related to trait measures of AHs. These findings contribute to the literature of resting eyes closed EEG recordings of schizophrenia and AHs, and indi...
Source: Clinical EEG and Neuroscience - October 19, 2020 Category: Neuroscience Authors: Arora M, Knott VJ, Labelle A, Fisher DJ Tags: Clin EEG Neurosci Source Type: research

The First Unprovoked Seizure in Typically Developing Children: A Real-Life Setting in Southern Brazil.
Abstract AIM: To describe the first unprovoked seizure in typically developing children, its clinical characteristics, recurrence rate, and possible risk factors in a real-life setting in Southern Brazil. METHOD: In this retrospective cohort study, medical records of typically developing children aged 28 days to 14 years who had a first unprovoked seizure in a single tertiary care center were reviewed, in a 10-year period (2006-2016). RESULTS: Seventy-four children were included, 41 males and 33 females. The most frequent age group of the first seizure was 5 to 10 years and seizure main type was focal (5...
Source: Clinical EEG and Neuroscience - October 13, 2020 Category: Neuroscience Authors: de Rezende Machado M, Bruck I, de Paola L, Cat MNL, Antoniuk SA, Silvado CES Tags: Clin EEG Neurosci Source Type: research

Prediction of Depression Severity Scores Based on Functional Connectivity and Complexity of the EEG Signal.
This study aims to specify whether functional connectivity and complexity of brain activity can predict the severity of depression (Beck Depression Inventory-II scores). METHODS: Resting-state, eyes-closed EEG data were recorded from 60 depressed patients. A phase synchronization measure was used to estimate functional connectivity between all pairs of the EEG channels in the delta (1-4 Hz), theta (4-8 Hz), alpha (8-13 Hz), and beta (13-30 Hz) frequency bands. To quantify the local value of functional connectivity, 2 graph theory metrics, degree, and clustering coefficient (CC), were measured. Moreover, Lempel-Ziv com...
Source: Clinical EEG and Neuroscience - October 11, 2020 Category: Neuroscience Authors: Mohammadi Y, Moradi MH Tags: Clin EEG Neurosci Source Type: research

Quantitative EEG in Childhood Attention Deficit Hyperactivity Disorder and Learning Disabilities.
Abstract The clinical use of the quantitative EEG (QEEG) from the pioneering work of John has received a new impetus thanks to new neuroimaging techniques and the possibility of using a number of normative databases both of normal subjects and of subjects with definite pathologies. In this direction, the term personalized medicine is becoming more and more common, a medical procedure that separates patients into different groups based on their predicted response to the quantitative EEG. This has allowed the study of single subjects and to customize health care, with decisions and treatments tailored to each indivi...
Source: Clinical EEG and Neuroscience - October 4, 2020 Category: Neuroscience Authors: Chiarenza GA Tags: Clin EEG Neurosci Source Type: research

Special Report on the Impact of the COVID-19 Pandemic on Clinical EEG and Research and Consensus Recommendations for the Safe Use of EEG.
CONCLUSIONS: The COVID-19 pandemic interfered with the use of EEG recordings in clinical practice and even more in clinical research. We suggest updated best practices to allow safe EEG recordings in both research and clinical settings. The continued use of EEG is important in those with psychiatric diseases, particularly in times of social alarm such as the COVID-19 pandemic. PMID: 32975150 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - September 24, 2020 Category: Neuroscience Authors: Campanella S, Arikan K, Babiloni C, Balconi M, Bertollo M, Betti V, Bianchi L, Brunovsky M, Buttinelli C, Comani S, Di Lorenzo G, Dumalin D, Escera C, Fallgatter A, Fisher D, Giordano GM, Guntekin B, Imperatori C, Ishii R, Kajosch H, Kiang M, López-Caned Tags: Clin EEG Neurosci Source Type: research

A Systematic Review of Altered P300 Event-Related Potential in Apolipoprotein E4 (APOE4) Carriers.
CONCLUSION: Evidence shows that APOE4 negatively influences cortical activities related to cognitive functions, as indicated by P300. PMID: 32945192 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - September 17, 2020 Category: Neuroscience Authors: Pedroso RV, Fraga FJ, Pavarini SCI, Nascimento CMC, Ayán C, Cominetti MR Tags: Clin EEG Neurosci Source Type: research

Interhemispheric Connectivity in Idiopathic Cervical Dystonia and Spinocerebellar Ataxias: A Transcranial Magnetic Stimulation Study.
Abstract BACKGROUND AND RATIONALE: Hyperkinetic movement disorders represent a heterogeneous group of diseases, different from a genetic and clinical perspective. In the past, neurophysiological approaches provided different, sometimes contradictory findings, pointing to an impaired cortical inhibition as a common electrophysiological marker. Our aim was to evaluate changes in interhemispheric communication in patients with idiopathic cervical dystonia (ICD) and spinocerebellar ataxias (SCAs). MATERIALS AND METHODS: Eleven patients with ICD, 7 with genetically confirmed SCA2 or SCA3, and 10 healthy volunteers...
Source: Clinical EEG and Neuroscience - September 16, 2020 Category: Neuroscience Authors: Bocci T, Baloscio D, Ferrucci R, Briscese L, Priori A, Sartucci F Tags: Clin EEG Neurosci Source Type: research

Transcranial Direct Current Stimulation Combined With Cognitive Training Induces Response Inhibition Facilitation Through Distinct Neural Responses According to the Stimulation Site: A Follow-up Event-Related Potentials Study.
CONCLUSION: CRP combined with active tDCS over the rDLPFC appears to be optimal for boosting long-term (one week) inhibitory skills as it induced specific and robust neural changes. PMID: 32924586 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - September 13, 2020 Category: Neuroscience Authors: Dousset C, Ingels A, Schröder E, Angioletti L, Balconi M, Kornreich C, Campanella S Tags: Clin EEG Neurosci Source Type: research

Electroclinical Phenotype-Genotype Homogeneity in Drug-Resistant "Generalized" Tonic-Clonic Seizures of Early Childhood.
CONCLUSIONS: These cases suggest that children with early-onset drug-resistant "generalized" epilepsy are likely to have a genetic basis although the presentation may not be typical of Dravet syndrome. Hence, genetic testing for SCN1A variants is recommended in children with drug-resistant MRI negative focal-onset/generalized-onset bilateral tonic-clonic seizures before subjecting them to exhaustive presurgical workup and to guide appropriate treatment and prognostication. PMID: 32880473 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - September 2, 2020 Category: Neuroscience Authors: Jukkarwala A, Menon RN, Sunesh ER, Radhakrishnan A Tags: Clin EEG Neurosci Source Type: research

The Yield of Ambulatory EEG-Video Monitoring.
CONCLUSION: Ambulatory EEG-video monitoring may be a useful alternative to inpatient epilepsy monitoring unit, particularly with high clinical suspicion for nonepileptic events. PMID: 32808544 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - August 17, 2020 Category: Neuroscience Authors: Primiani CT, Rivera-Cruz A, Trudeau P, Sullivan L, MacIver S, Benbadis SR Tags: Clin EEG Neurosci Source Type: research

Perampanel Increases Cortical EEG Fast Activity in Child and Adult Patients Affected by Epilepsy: A Quantitative EEG Study.
CONCLUSIONS: This qEEG study documented the relative increase of cortical EEG fast activity in both children and adult patients affected by epilepsy and treated by PER. This result may suggest a potential less negative impact of PER on cognition in patients affected by epilepsy, other than demonstrating effectiveness of the drug when used as first add-on treatment in both children and adult patients. PMID: 32762352 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - August 6, 2020 Category: Neuroscience Authors: Liguori C, Spanetta M, Izzi F, Russo A, Guerra A, Mercuri NB, Placidi F Tags: Clin EEG Neurosci Source Type: research

Efficacy and Safety of Ketamine in Refractory/Super-refractory Nonconvulsive Status Epilepticus: Single-Center Experience.
Abstract Refractory/super-refractory nonconvulsive status epilepticus (r/srNCSE) is an acute life-threatening neurocritical entity with significant morbidity. Failure to control SE in its earlier stages leads to multiple molecular alterations in the brain such as downregulation of GABA-A and upregulation of NMDA receptors. Recently ketamine, an NMDA receptor antagonist, has gained increased attention as a therapeutic choice in controlling refractory/super-refractory SE. We aimed to analyze the efficacy and safety profile of ketamine in our center. We retrospectively identified all the patients with nonconvulsive S...
Source: Clinical EEG and Neuroscience - August 4, 2020 Category: Neuroscience Authors: Dericioglu N, Arslan D, Arsava EM, Topcuoglu MA Tags: Clin EEG Neurosci Source Type: research

Development of Frontal EEG Differences Between Eyes-Closed and Eyes-Open Resting Conditions in Children: Data From a Single-Channel Dry-Sensor Portable Device.
Abstract Changes in EEG when moving from an eyes-closed to an eyes-open resting condition result from bottom-up sensory processing and have been referred to as activation. In children, activation is characterized by a global reduction in alpha, frontally present reductions for delta and theta, and a frontal increase for beta. The present study aimed to replicate frontal EEG activation effects using single-channel, dry-sensor EEG, and to extend current understanding by examining developmental change in children. Frontal EEG was recorded using a single-channel, dry-sensor EEG device while 182 children aged 7 to 12 y...
Source: Clinical EEG and Neuroscience - July 30, 2020 Category: Neuroscience Authors: Johnstone SJ, Jiang H, Sun L, Rogers JM, Valderrama J, Zhang D Tags: Clin EEG Neurosci Source Type: research

EEG Markers in Emotionally Unstable Personality Disorder-A Possible Outcome Measure for Neurofeedback: A Narrative Review.
Conclusions. The findings heterogeneity may be due to the disorder complexity and the variable EEG related parameters studied. An alternative explanation may be that there are a number of different neuromarkers, which could be clustered together with clinical symptomatology, to give new subdomains. Quantitative EEGs in particular may be helpful to identify more specific abnormalities. EEG standardization of neurofeedback protocols based on specific EEG abnormalities detected may facilitate targeted use of neurofeedback as an intervention in EUPD. PMID: 32635758 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - July 7, 2020 Category: Neuroscience Authors: Boland C, Jalihal V, Organ C, Oak K, McLean B, Laugharne R, Woldman W, Beck R, Shankar R Tags: Clin EEG Neurosci Source Type: research

Robert W McCarley's Multimodal Imaging Group Genealogy.
PMID: 32628086 [PubMed - in process] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - June 30, 2020 Category: Neuroscience Authors: Salisbury DF Tags: Clin EEG Neurosci Source Type: research

Localizing the Primary Motor Cortex of the Hand by the 10-5 and 10-20 Systems for Neurostimulation: An MRI Study.
Conclusion. The C3h/C4h and C1/C2 points were more accurate when compared with the C3 and C4 points in locating the M1-Hand correspondence on the scalp. PMID: 32611200 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - June 30, 2020 Category: Neuroscience Authors: Silva LM, Silva KMS, Lira-Bandeira WG, Costa-Ribeiro AC, Araújo-Neto SA Tags: Clin EEG Neurosci Source Type: research

Enhanced Descending Corticomuscular Coupling During Hand Grip With Static Force Compared With Enhancing Force.
Abstract The interaction between cortex and muscles under hand motor with different force states has not been quantitatively investigated yet, which to some extent places the optimized movement tasks design for brain-computer interface (BCI) applications in hand motor rehabilitation under uncertainty. Converging evidence has suggested that both the descending corticospinal pathway and ascending sensory feedback pathway are involved in the generation of corticomuscular coupling. The present study aimed to explore the corticomuscular coupling during hand motor task with enhancing force and steady-state force. Twenty...
Source: Clinical EEG and Neuroscience - June 30, 2020 Category: Neuroscience Authors: Gao L, Wu H, Cheng W, Lan B, Ren H, Zhang L, Wang L Tags: Clin EEG Neurosci Source Type: research

Active and Passive Attentional Processing in Adolescent Suicide Attempters: An Event-Related Potential Study.
CONCLUSIONS: This is the first study to explore both passive and controlled aspects of attention using ERPs in adolescents with acute suicidal behavior. Although there were no significant ERP group differences, this is an important step in identifying objective markers of suicide risk among adolescents. PMID: 32579028 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - June 23, 2020 Category: Neuroscience Authors: Tavakoli P, Boafo A, Jerome E, Campbell K Tags: Clin EEG Neurosci Source Type: research

Frontal Beta Activity in the Meta-Intention of Children With Attention Deficit Hyperactivity Disorder.
Abstract Children with attention deficit hyperactivity disorder (ADHD) have high theta and low beta activity in the frontal lobe. The higher the theta/beta ratio, the lower the level of central nervous system (CNS) cortical arousal. However, there is seldom evidence between electroencephalograms (EEGs) and the patient's intentionality to regulate the cortical activity of executive attention tasks. We investigated whether children with ADHD intended to improve their performance in executive attention tasks and whether that increased their brain activity. Fifty-one children with ADHD (ADHD) and 51 typical developing...
Source: Clinical EEG and Neuroscience - June 21, 2020 Category: Neuroscience Authors: Liao YC, Guo NW, Su BY, Chen SJ, Tsai HF, Lee KY Tags: Clin EEG Neurosci Source Type: research

The Investigation of Simultaneous EEG and Eye Tracking Characteristics During Fixation Task in Mild Alzheimer's Disease.
This study provides evidence for the simultaneously EEG and eye-tracking changes in the areas, which are involved in the control of the fixational eye movements. PMID: 32539459 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - June 15, 2020 Category: Neuroscience Authors: Moghadami M, Moghimi S, Moghimi A, Malekzadeh GR, Fadardi JS Tags: Clin EEG Neurosci Source Type: research

Propofol-Bispectral Index (BIS) Electroencephalography (EEG) Pharmacokinetic-Pharmacodynamic Model in Patients With Post-Cerebral Hemorrhage Hydrocephalus.
Conclusions. Using BIS as surrogate marker of propofol hypnotic effect, BIS monitoring in patients with post-cerebral hemorrhage hydrocephaly showed a pattern of change and trend that was similar albeit 39% significantly lower than subjects without. PMID: 32527157 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - June 10, 2020 Category: Neuroscience Authors: Dahaba AA, Lin H, Ye XF, Zhang N, Wang K, Reibnegger G, Lian QQ Tags: Clin EEG Neurosci Source Type: research

An Observational Retrospective Study Investigating Changes in Seizure Adequacy Parameters of Electroconvulsive Therapy and Their Relationships to Clinical Outcome in Schizophrenia and Schizoaffective Disorder.
T Abstract The aim of the current study was to investigate a possible relationship between electroconvulsive therapy (ECT) seizure adequacy parameters and clinical outcome as well as differences between ECT responders and nonresponders in terms of ECT seizure parameters in patients diagnosed with schizophrenia and schizoaffective disorder. First and last ECT records data, sociodemographic variables, and baseline and post ECT Positive and Negative Syndrome Scale scores were obtained. Maximum sustained power was higher in last ECT in favor of responders while peak heart rate was higher in ECT nonresponders than re...
Source: Clinical EEG and Neuroscience - June 10, 2020 Category: Neuroscience Authors: Durmaz O, Öcek Baş T Tags: Clin EEG Neurosci Source Type: research

Major Depressive Disorder Classification Based on Different Convolutional Neural Network Models: Deep Learning Approach.
n N Abstract The human brain is characterized by complex structural, functional connections that integrate unique cognitive characteristics. There is a fundamental hurdle for the evaluation of both structural and functional connections of the brain and the effects in the diagnosis and treatment of neurodegenerative diseases. Currently, there is no clinically specific diagnostic biomarker capable of confirming the diagnosis of major depressive disorder (MDD). Therefore, exploring translational biomarkers of mood disorders based on deep learning (DL) has valuable potential with its recently underlined promising outc...
Source: Clinical EEG and Neuroscience - June 2, 2020 Category: Neuroscience Authors: Uyulan C, Ergüzel TT, Unubol H, Cebi M, Sayar GH, Nezhadasad M, Tarhan N Tags: Clin EEG Neurosci Source Type: research

Electroencephalographic Grading of Neuronal Dysfunction in Various Etiologies of Encephalopathy.
CONCLUSION: EEG is being conducted routinely to determine the course and severity of various forms of encephalopathy. However, the clinical implications of EEG grading for neuronal dysfunction are largely dependent on underlying etiology and other clinical parameters, such as age and GCS score. Further larger prospective cohort studies involving other important prognostic parameters and continuous EEG monitoring are thus needed. PMID: 32483980 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - June 1, 2020 Category: Neuroscience Authors: Alkhamis F, Nazish S Tags: Clin EEG Neurosci Source Type: research

Effects of Transcranial Direct Current Stimulation on Visual Neuroplasticity in Schizophrenia.
Abstract People with schizophrenia (SZ) exhibit visual processing abnormalities that affect their daily functioning and remediating these deficits might help to improve functioning. Transcranial direct current stimulation (tDCS) is a potential tool for perceptual enhancement for this purpose, though there are no reports of tDCS applied to visual cortex in SZ. In a within-subject, crossover design, we evaluated the effects of tDCS on visual processing in 27 SZ. All patients received anodal, cathodal, or sham stimulation over the central occipital region in 3 visits separated by 1 week. In each visit, a backward mas...
Source: Clinical EEG and Neuroscience - May 27, 2020 Category: Neuroscience Authors: Jahshan C, Wynn JK, Roach BJ, Mathalon DH, Green MF Tags: Clin EEG Neurosci Source Type: research

Evidence From Meta-Analysis Supports Ictal Magnetoencephalographic Source Imaging as an Accurate Method in Presurgery Evaluation of Patients With Drug-Resistant Epilepsy.
CONCLUSION.: The meta-analysis supports that iMSI is an accurate method, achieving similar sensitivity and higher specificity than icEEG. However, at present the use of the method is limited by short recording times. A limitation that might be overcome in the future using technical advances. PMID: 32437218 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - May 20, 2020 Category: Neuroscience Authors: Brændholt M, Jensen M Tags: Clin EEG Neurosci Source Type: research

Habituation of P300 in the Use of P300-based Brain-Computer Interface Spellers: Individuals With Amyotrophic Lateral Sclerosis Versus Age-Matched Controls.
Abstract The P300-based brain-computer interface speller can provide motor independent communication to individuals with amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disorder that affects the motor system. P300 amplitude stability is critical for operation of the P300 speller. The P300 has good long-term stability, but to our knowledge, short-term habituation in the P300 speller has not been studied. In the current study, 15 participants: 8 ALS patients and 7 age-matched healthy volunteers (HVs), used 2 versions of P300 spellers, Face speller and Flash speller, each for 30 minutes. The ALS ...
Source: Clinical EEG and Neuroscience - May 17, 2020 Category: Neuroscience Authors: Yu X, da Silva-Sauer L, Donchin E Tags: Clin EEG Neurosci Source Type: research

Congruence and Discrepancy of Interictal and Ictal EEG With MRI Lesions in Pediatric Epilepsies.
Conclusions. MRI lesions and EEG findings are rarely fully congruent. Congruence of MRI lesions and ESPs was highest in children with frontal lesions. This is in contrast to adults, in whom temporal lesions showed the highest congruency with the EEG localization of ESP. Lesional pediatric patients should be acknowledged as surgical candidates despite incongruent findings of interictal and ictal surface EEG. PMID: 32420750 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - May 17, 2020 Category: Neuroscience Authors: Rémi J, Shen S, Tacke M, Probst P, Gerstl L, Peraud A, Kunz M, Vollmar C, Noachtar S, Borggraefe I Tags: Clin EEG Neurosci Source Type: research

Clinical Correlates of Frontal Intermittent Rhythmic Delta Activity Without Structural Brain Lesion.
Abstract Frontal intermittent rhythmic delta activity (FIRDA), rhythmic slow wave pattern lasting several seconds over the anterior leads of electroencephalography (EEG), has been reported in a wide variety of clinical conditions. We investigated the clinical significance of FIRDA without structural brain lesions. We reviewed 7689 EEGs between October 2017 and September 2019 at a university hospital. Patients (age>18 years) who were confirmed to have "nonsignificant neuroimaging" were examined. Clinical data were retrospectively collected, and the estimated cause was carefully decided. We found 83 FIR...
Source: Clinical EEG and Neuroscience - May 14, 2020 Category: Neuroscience Authors: Kim KT, Roh YN, Cho NH, Jeon JC Tags: Clin EEG Neurosci Source Type: research

A Longitudinal, Prospective Study to Evaluate the Effects of Treatment on the Inhibitory Control Function After Transsphenoidal Surgery for Pituitary Adenomas.
CONCLUSIONS: These results indicated that presurgery patients showed the dysfunction of inhibition, due to the nerve tissue damage or brain structure alteration caused by the presurgery physical pressure from tumor and abnormal hormone levels. Postsurgery patients showed a tendency toward recovery, but there was no obvious improvement in the inhibitory control function after successful treatments. PMID: 32412816 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - May 14, 2020 Category: Neuroscience Authors: Cao C, Song J, Lin P, Yan D, Yao S, Yue J, Liu B, Lu Y, Xu G Tags: Clin EEG Neurosci Source Type: research

Generalized Periodic Discharges With Triphasic Morphology in the Setting of Aztreonam Neurotoxicity.
Abstract Generalized periodic discharges with triphasic morphology (GPDs + TWm) have been reported with multiple metabolic and drug toxicities. Beta-lactam antibiotics in some cases can cause neurotoxicity with GPDs + TWm on EEG. There are no reports in the literature of aztreonam causing neurotoxicity and GPDs + TWm. Here we describe GPDs + TWm and encephalopathy developing in a patient with underlying dementia and acute kidney injury who was started on aztreonam for cystitis. Neurotoxic effects of beta-lactam antibiotics have been well studied at this point, likely related to GABA receptor antagonism by the beta...
Source: Clinical EEG and Neuroscience - May 12, 2020 Category: Neuroscience Authors: Billnitzer A, Kaplan PW Tags: Clin EEG Neurosci Source Type: research

QEEG as a Useful Tool for the Evaluation of Early Cognitive Changes in Dementia and Traumatic Brain Injury.
Abstract Quantitative electroencephalography (QEEG)-electrical neuroimaging has been underutilized in general neurology practice. Recent advances in computer technology have made this electrophysiological testing relatively inexpensive as well as precise in identifying brain areas with electrical dysfunction related to either traumatic injury or neurodegenerative process. In this article, the author presents 2 cases that can be frequently encountered in every general neurological practice: case of early dementia and traumatic brain injury. The clinical usefulness of QEEG is demonstrated by showing evidence of elec...
Source: Clinical EEG and Neuroscience - May 10, 2020 Category: Neuroscience Authors: Koberda JL Tags: Clin EEG Neurosci Source Type: research

Brain Activation Imaging in Emotional Decision Making and Mental Health: A Review-Part 1.
Abstract In part 1 of this article, we describe an approach and methodology that bridges 2 worlds: the internal, subjective experience of emotions and thoughts, and the external world of brain electrical activity. Using a novel event-related brain activation imaging method, we demonstrate that within single trials, short-term mental processes, on the order of 100 ms, can be clearly related to observed brain activation in controlled experiments. We use an ipsative assessment validation process that combines self-report with real-time EEG recordings to provide a combined picture of both the mental and the brain acti...
Source: Clinical EEG and Neuroscience - May 6, 2020 Category: Neuroscience Authors: Bonnstetter RJ, Collura TF Tags: Clin EEG Neurosci Source Type: research

Quantitative EEG Findings in Patients With Psychogenic Nonepileptic Seizures.
Conclusion. Our findings show that PNES correlate with high-frequency oscillations on central motor and somatosensory cortices. PMID: 32362136 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - May 3, 2020 Category: Neuroscience Authors: Arıkan K, Öksüz Ö, Metin B, Günver G, Laçin Çetin H, Esmeray T, Tarhan N Tags: Clin EEG Neurosci Source Type: research

Brain Activation Imaging in Emotional Decision Making and Mental Health: A Review-Part 2.
In this report, we integrate the principles described in part 1 and describe an operational model for emotional decision making that incorporates brain activation data along with subjective experience correlates. This model takes the form of a state machine that carries out transitions between a finite set of 16 possible states of emotional and decision-making response. By considering a 4 × 4 grid of possible states based on left and right activation, in primary (sensation) and secondary (perception/comprehension) response, the range of responses is completely specified. The transition probabilities within this reper...
Source: Clinical EEG and Neuroscience - May 2, 2020 Category: Neuroscience Authors: Collura TF, Bonnstetter RJ Tags: Clin EEG Neurosci Source Type: research

Sex Differences in QEEG in Psychopath Offenders.
dés-Sosa M Abstract Introduction. Functional brain differences related to sex in psychopathic behavior represent an important field of neuroscience research; there are few studies on this area, mainly in offender samples. Objective. The aim of this study was to investigate the presence of electrophysiological differences between male and female psychopath offenders; specifically, we wanted to assess whether the results in quantitative EEG, low-resolution electromagnetic tomography (LORETA), and changes in synchronous brain activity could be related to sex influence. Sample and Methods. The study included 31...
Source: Clinical EEG and Neuroscience - April 5, 2020 Category: Neuroscience Authors: Calzada-Reyes A, Alvarez-Amador A, Galán-García L, Valdés-Sosa M Tags: Clin EEG Neurosci Source Type: research

Pitch and Duration Mismatch Negativity and Heschl's Gyrus Volume in First-Episode Schizophrenia-Spectrum Individuals.
Conclusions. pMMN and dMMN index gray matter reduction in left hemisphere auditory cortex early in psychosis, with dMMN also marginally indexing right HG volumes. This suggest conjoint functional and structural pathology that affects the automatic detection of novelty with varying degrees of penetrance prior to psychosis. These brainwaves are sensitive biomarkers of pathology early in the psychotic disease course, and may serve as biomarkers of disease progression and as therapeutic outcome measures. PMID: 32241184 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - April 2, 2020 Category: Neuroscience Authors: Salisbury DF, Shafer AR, Murphy TK, Haigh SM, Coffman BA Tags: Clin EEG Neurosci Source Type: research

Auditory Cortex Volume and Gamma Oscillation Abnormalities in Schizophrenia.
Abstract We investigated whether the gray matter volume of primary auditory cortex (Heschl's gyrus [HG]) was associated with abnormal patterns of auditory γ activity in schizophrenia, namely impaired γ synchronization in the 40-Hz auditory steady-state response (ASSR) and increased spontaneous broadband γ power. (The γ data were previously reported in Hirano et al, JAMA Psychiatry, 2015;72:813-821). Participants were 24 healthy controls (HC) and 23 individuals with chronic schizophrenia (SZ). The ASSR was obtained from the electroencephalogram to click train stimulation at 20, 30, and 40 Hz...
Source: Clinical EEG and Neuroscience - March 22, 2020 Category: Neuroscience Authors: Hirano Y, Oribe N, Onitsuka T, Kanba S, Nestor PG, Hosokawa T, Levin M, Shenton ME, McCarley RW, Spencer KM Tags: Clin EEG Neurosci Source Type: research

Serum Neurosteroid Levels Are Associated With Cortical Thickness in Individuals Diagnosed With Posttraumatic Stress Disorder and History of Mild Traumatic Brain Injury.
This study included 141 individuals divided into the following groups: (a) mTBI group (n = 32 [10 female, 22 male] veterans with a history of mTBI); (b) PTSD + mTBI group (n = 41 [6 female, 35 male] veterans with current PTSD with a history of mTBI); and (c) control group (n = 68 [35 female, 33 male] control participants), which were acquired through the Injury and Traumatic Stress (INTRuST) Clinical Consortium. Subjects underwent clinical assessment, magnetic resonance imaging at 3 T, and serum neurosteroid quantifications of allopregnanolone (ALLO) and pregnenolone (PREGN). Group differences in cortical thickness and ass...
Source: Clinical EEG and Neuroscience - March 17, 2020 Category: Neuroscience Authors: Kinzel P, Marx CE, Sollmann N, Hartl E, Guenette JP, Kaufmann D, Bouix S, Pasternak O, Rathi Y, Coleman MJ, van der Kouwe A, Helmer K, Kilts JD, Naylor JC, Morey RA, Shutter L, Andaluz N, Coimbra R, Lang AJ, George MS, McAllister TW, Zafonte R, Stein MB, Tags: Clin EEG Neurosci Source Type: research

Studying the Effect of Maternal Pregestational Diabetes on Fetal Neurodevelopment Using Magnetoencephalography.
In this study, we aimed to explore the effect of maternal pregestational diabetes on the fetal brain activity using magnetoencephalography (MEG). Methods. Forty participants were included in an observational study with 9 type 1 and 19 type 2 diabetic pregnant women compared with data from 12 nondiabetic participants. Spontaneous fetal MEG signals were recorded and power spectral density was computed in 4 standard frequency bands. Group differences were investigated using analysis of covariance. Results. Our results showed that type 1 group was significantly different (P
Source: Clinical EEG and Neuroscience - March 10, 2020 Category: Neuroscience Authors: Avci R, Whittington JR, Blossom SJ, Escalona-Vargas D, Siegel ER, Preissl HT, Eswaran H Tags: Clin EEG Neurosci Source Type: research

Clinical and Radiological Correlates of Different Electroencephalographic Pattern in Hospitalized Patients.
Conclusion. At present, certain EEG patterns cannot be precisely correlated with imaging findings, suggesting that intercurrent metabolic, infectious, and/or toxic contributors could be the confounding factors. Nonetheless, when EEG patterns are examined alongside magnetic resonance imaging findings and other clinically relevant data, these might be indicative of a group of diseases in some pertinent situations. Thus, further larger prospective clinical studies that incorporate continuous EEG monitoring, advanced radiology techniques, and laboratory analyses would be beneficial to elucidate their interplay for better firm ...
Source: Clinical EEG and Neuroscience - March 5, 2020 Category: Neuroscience Authors: Nazish S Tags: Clin EEG Neurosci Source Type: research

Clinical and Genetic Profile of Autism Spectrum Disorder-Epilepsy (ASD-E) Phenotype: Two Sides of the Same Coin!
Abstract The clinical phenotype of autism spectrum disorder and epilepsy (ASD-E) is a common neurological presentation in various genetic disorders, irrespective of the underlying pathophysiological mechanisms. Here we describe the demographic and clinical profiles, coexistent neurological conditions, type of seizures, epilepsy syndrome, and EEG findings in 11 patients with ASD-E phenotype with proven genetic etiology. The commonest genetic abnormality noted was CDKL5 mutation (3), MECP2 mutation (2), and 1p36 deletion (2). The median age of onset of clinical seizures was 6 months (range, 10 days to 11 years). The...
Source: Clinical EEG and Neuroscience - March 1, 2020 Category: Neuroscience Authors: Karunakaran S, Menon RN, Nair SS, Santhakumar S, Nair M, Sundaram S Tags: Clin EEG Neurosci Source Type: research

Entropy: A Promising EEG Biomarker Dichotomizing Subjects With Opioid Use Disorder and Healthy Controls.
Abstract Electroencephalography (EEG) signals are known to be nonstationary and often multicomponential signals containing information about the condition of the brain. Since the EEG signal has complex, nonlinear, nonstationary, and highly random behaviour, numerous linear feature extraction methods related to the short-time windowing technique do not satisfy higher classification accuracy. Since biosignals are highly subjective, the symptoms may appear at random in the time scale and very small variations in EEG signals may depict a definite type of brain abnormality it is valuable and vital to extract and analyz...
Source: Clinical EEG and Neuroscience - February 10, 2020 Category: Neuroscience Authors: Erguzel TT, Uyulan C, Unsalver B, Evrensel A, Cebi M, Noyan CO, Metin B, Eryilmaz G, Sayar GH, Tarhan N Tags: Clin EEG Neurosci Source Type: research

Orbitofrontal Sulcogyral Pattern as a Transdiagnostic Trait Marker of Early Neurodevelopment in the Social Brain.
Conclusions. The present review of the orbitofrontal sulcogyral pattern indicated that type I expression might reflect a neurodevelopmental protective marker, and type II and III expressions, as well as fewer numbers of IOS and POS, might reflect neurodevelopmental risk markers. These trait markers may be transdiagnostic among socially disabling diseases. PMID: 32028799 [PubMed - as supplied by publisher] (Source: Clinical EEG and Neuroscience)
Source: Clinical EEG and Neuroscience - February 5, 2020 Category: Neuroscience Authors: Nakamura M, Nestor PG, Shenton ME Tags: Clin EEG Neurosci Source Type: research

Delay Maturation in Occipital Lobe in Girls With Inattention Subtype of Attention-Deficit Hyperactivity Disorder.
Abstract Attention-deficit hyperactivity disorder (ADHD) is a common childhood neuropsychiatric disorder. Differences in the presentations of ADHD between boys and girls have been well established. Three subtypes of ADHD exist. In addition to sex difference, different mechanisms may underlie different subtypes. The present study enrolled 30 girls with the inattentive subtype of ADHD and 30 age-matched controls. Low-resolution electromagnetic tomography (LORETA) and instantaneous frequency were used to analyze electroencephalography (EEG) for investigating the brain area and EEG bands involved in girls with inatten...
Source: Clinical EEG and Neuroscience - January 13, 2020 Category: Neuroscience Authors: Chang TM, Yang RC, Chiang CT, Ouyang CS, Wu RC, Yu S, Lin LC Tags: Clin EEG Neurosci Source Type: research

P50, N100, and P200 Sensory Gating in Panic Disorder.
Plag J Abstract Panic disorder (PD) has been linked to abnormalities in information processing. However, only little evidence has been published for sensory gating in PD. Sensory gating describes the brain's ability to exclude stimuli of low relevance from higher level information processing, thereby sustaining efficient cognitive processing. Deficits in sensory gating have been associated with various psychiatric conditions, most prominently schizophrenia. In this case-control event-related potential study, we tested 32 patients with PD and 39 healthy controls in a double click paradigm. Both groups were compare...
Source: Clinical EEG and Neuroscience - January 8, 2020 Category: Neuroscience Authors: Thoma L, Rentzsch J, Gaudlitz K, Tänzer N, Gallinat J, Kathmann N, Ströhle A, Plag J Tags: Clin EEG Neurosci Source Type: research

Ipsilateral Corticospinal Tract Excitability Contributes to the Severity of Mirror Movements in Unilateral Cerebral Palsy: A Case Series.
Abstract Mirror movements (MM) can be a clinical manifestation of unilateral cerebral palsy (UCP) causing involuntary movements when attempting to use either hand for functional activities. Atypical development of the corticospinal tract (CST) contributes to impairments in observed motor movements and functional activities. However, little is known about the underlying neurophysiology and contribution of the CST to MM. The current case study characterizes MM in 13 children and young adults with UCP ranging in age from 7 to 19 years and includes clinical and neurophysiologic variables. Clinical profiles included MM...
Source: Clinical EEG and Neuroscience - January 7, 2020 Category: Neuroscience Authors: Rich TL, Nemanich S, Chen CY, Sutter EN, Feyma T, Krach LE, Gillick BT Tags: Clin EEG Neurosci Source Type: research

Autism, Epilepsy, and Neuroregression: Photosensitivity on Electroencephalography Solved the Riddle.
Abstract Autistic epileptiform regression is an uncommon but extensively described malady in children. The clinico-etiological spectrum of this entity ranges from electrical status epilepticus in sleep to various neurogenetic and neurodegenerative disorders. Identification of these disorders is crucial considering their therapeutic and prognostic implications. Simple investigations such as neuroimaging and electroencephalography with activation procedures can provide valuable diagnostic clues in resource-limited settings; facilitating targeted genetic/metabolic testing. Here we report a 3.5-year-old girl with auti...
Source: Clinical EEG and Neuroscience - January 5, 2020 Category: Neuroscience Authors: Madaan P, Jauhari P, Luhar ZM, Chakrabarty B, Gulati S Tags: Clin EEG Neurosci Source Type: research

Altered P3a Modulations to Emotional Faces in Male Patients With Chronic Schizophrenia.
Abstract Existing evidence suggests that patients with schizophrenia may have a deficit in processing facial expressions. However, the neural basis of this processing deficit remains unclear. A total of 20 men diagnosed with chronic schizophrenia and 13 age- and sex-matched controls participated in the study. We investigated visual N170 and P3a components evoked in response to fearful, happy, and sad faces during an emotion discrimination task. Compared with control subjects, patients showed significantly smaller N170 amplitudes bilaterally (P = .04). We found no significant main effect of emotion of the presented...
Source: Clinical EEG and Neuroscience - January 1, 2020 Category: Neuroscience Authors: Onitsuka T, Spencer KM, Nakamura I, Hirano Y, Hirano S, McCarley RW, Shenton ME, Niznikiewicz MA Tags: Clin EEG Neurosci Source Type: research