Dispersion of ventricular repolarization: Temporal and spatial.
Abstract Repolarization heterogeneity (RH) is an intrinsic property of ventricular myocardium and the reason for T-wave formation on electrocardiogram (ECG). Exceeding the physiologically based RH level is associated with appearance of life-threatening ventricular arrhythmias and sudden cardiac death. In this regard, an accurate and comprehensive evaluation of the degree of RH parameters is of importance for assessment of heart state and arrhythmic risk. This review is devoted to comprehensive consideration of RH phenomena in terms of electrophysiological processes underlying RH, cardiac electric field formation d...
Source: World Journal of Cardiology - September 26, 2020 Category: Cardiology Authors: Arteyeva NV Tags: World J Cardiol Source Type: research

Clinical significance of prolonged chest pain in vasospastic angina.
This study included 167 patients with VSA diagnosed by spasm provocation tests (SPTs) using acetylcholine, which recorded the frequencies of positive reactions to a low dose of acetylcholine (L-ACh), total occlusion due to spasm (TOC), focal spasm, and the unavoidable use of nitroglycerin (unavoidable-NTG) during SPTs. The patients underwent a medical interview that investigated the maximum duration and frequency of chest symptoms as well as the frequencies of variant angina and other serious symptoms. The patients were divided into two groups based on the maximal duration: The short-duration group (
Source: World Journal of Cardiology - September 26, 2020 Category: Cardiology Authors: Teragawa H, Oshita C, Orita Y Tags: World J Cardiol Source Type: research

Pericardial effusion with tamponade - an uncommon presentation leading to the diagnosis of eosinophilic granulomatosis polyangiitis: A case report.
CONCLUSION: This case highlights that when isolated pericardial involvement occurs in EGPA, diagnosis is recognized by performing pericardial biopsy demonstrating histopathologic evidence of eosinophilic infiltration. PMID: 33014293 [PubMed] (Source: World Journal of Cardiology)
Source: World Journal of Cardiology - September 26, 2020 Category: Cardiology Authors: Alam L, Lasam G, Fishberg R Tags: World J Cardiol Source Type: research

Diffuse coronary artery vasospasm in a patient with subarachnoid hemorrhage: A case report.
CONCLUSION: This case highlights a unique etiology of acute myocardial infarction in a patient with SAH leading to ST elevations, diffuse triple vessel CAV and apical scar. PMID: 33014294 [PubMed] (Source: World Journal of Cardiology)
Source: World Journal of Cardiology - September 26, 2020 Category: Cardiology Authors: Grewal D, Mohammad A, Swamy P, Abudayyeh I, Mamas MA, Parwani P Tags: World J Cardiol Source Type: research

Oliver Wendell Holmes' 1836 doctorate dissertation and his journey in medicine.
Abstract Oliver Wendell Holmes' 1836 hand written doctorate dissertation on acute pericarditis was discovered in the archives of the Boston Medical Library 101 years after it was successfully defended. It was then printed as an unabridged monograph with an explanation of its provenance. The dissertation has received little scrutiny since then. Holmes gathered materials for the scholarly work while he was a third and fourth year student at Ecole de Medecine in Paris. His mentor, Pierre-Charles-Alexandre- Louis insisted on the meticulous gathering and recording of every patient's history and findings. Each category ...
Source: World Journal of Cardiology - August 26, 2020 Category: Cardiology Authors: Cohen SI Tags: World J Cardiol Source Type: research

Classic Ehlers-Danlos syndrome and cardiac transplantation - Is there a connection?
Abstract Ehlers-Danlos syndrome (EDS) is a heterogeneous group of connective tissue disorders comprised of several types. Classic EDS is an autosomal dominant disorder with stretchable skin, delayed wound healing with poor scarring, joint hypermobility with subluxations or dislocations, easy bruisability, hernias, aneurysms and cardiac abnormalities. Advances in genomics technology using next-generation sequencing has led to the discovery of causative genes for connective tissue disorders, hereditary cardiomyopathies and cardiovascular diseases including several genes for connective tissue disorders. A 55 year-old...
Source: World Journal of Cardiology - August 26, 2020 Category: Cardiology Authors: Butler MG Tags: World J Cardiol Source Type: research

Sympathetic nervous system activation and heart failure: Current state of evidence and the pathophysiology in the light of novel biomarkers.
Abstract Heart failure (HF) is a complex clinical syndrome characterized by the activation of at least several neurohumoral pathways that have a common role in maintaining cardiac output and adequate perfusion pressure of target organs and tissues. The sympathetic nervous system (SNS) is upregulated in HF as evident in dysfunctional baroreceptor and chemoreceptor reflexes, circulating and neuronal catecholamine spillover, attenuated parasympathetic response, and augmented sympathetic outflow to the heart, kidneys and skeletal muscles. When these sympathoexcitatory effects on the cardiovascular system are sustained...
Source: World Journal of Cardiology - August 26, 2020 Category: Cardiology Authors: Borovac JA, D'Amario D, Bozic J, Glavas D Tags: World J Cardiol Source Type: research

Forensic interrogation of diabetic endothelitis in cardiovascular diseases and clinical translation in heart failure.
Abstract Diabetic heart disease (DHD) can be classified as a primary consequence from several pathophysiological manifestation of diabetes mellitus (DM) on cardiac tissues or secondarily in extracardiac tissues and is encountered as either primary or secondary complications of DM. Endothelitis is inflammation of the vascular endothelium and is likely to be seen in the majority of patients who start to manifest an end organ complication of DM in this case DHD. Diabetes is a leading cause for many cardiovascular syndromes and diseases including congestive heart failure (CHF) however much remains unknown about the tr...
Source: World Journal of Cardiology - August 26, 2020 Category: Cardiology Authors: Thomas MC, Iyngkaran P Tags: World J Cardiol Source Type: research

Impact of cardiologist intervention on guideline-directed use of statin therapy.
Abstract BACKGROUND: Statins have an important and well-established role in the prevention of atherosclerotic cardiovascular disease (ASCVD). However, several studies have reported widespread underuse of statins in various practice settings and populations. Review of relevant literature reveals opportunities for improvement in the implementation of guideline-directed statin therapy (GDST). AIM: To examine the impact of cardiologist intervention on the use of GDST in the ambulatory setting. METHODS: Patients with at least one encounter at the adult Internal Medicine Clinic (IMC) and/or Cardiology Clinic (...
Source: World Journal of Cardiology - August 26, 2020 Category: Cardiology Authors: Cassagnol M, Hai O, Sherali SA, D'Angelo K, Bass D, Zeltser R, Makaryus AN Tags: World J Cardiol Source Type: research

Systematic review and meta-analysis of outcomes of anatomic repair in congenitally corrected transposition of great arteries.
CONCLUSION: Operative mortality with anatomic repair strategy for cc-TGA is high. Despite that, transplant free survival after anatomic repair for cc-TGA patients is highly favorable. Majority of patients maintain NYHA I/II functional class. However, monitoring for burden of re-interventions specific for operation type is very essential. PMID: 32879705 [PubMed] (Source: World Journal of Cardiology)
Source: World Journal of Cardiology - August 26, 2020 Category: Cardiology Authors: Chatterjee A, Miller NJ, Cribbs MG, Mukherjee A, Law MA Tags: World J Cardiol Source Type: research

MicroRNA sequences modulating inflammation and lipid accumulation in macrophage "foam" cells: Implications for atherosclerosis.
MicroRNA sequences modulating inflammation and lipid accumulation in macrophage "foam" cells: Implications for atherosclerosis. World J Cardiol. 2020 Jul 26;12(7):303-333 Authors: Lightbody RJ, Taylor JMW, Dempsie Y, Graham A Abstract Accumulation of macrophage "foam" cells, laden with cholesterol and cholesteryl ester, within the intima of large arteries, is a hallmark of early "fatty streak" lesions which can progress to complex, multicellular atheromatous plaques, involving lipoproteins from the bloodstream and cells of the innate and adaptive immune response. Sterol a...
Source: World Journal of Cardiology - July 26, 2020 Category: Cardiology Authors: Lightbody RJ, Taylor JMW, Dempsie Y, Graham A Tags: World J Cardiol Source Type: research

Comprehensive review of hemolysis in ventricular assist devices.
Abstract Ventricular assist devices (VADs) have played an important role in altering the natural history of end-stage heart failure. Low-grade hemolysis has been traditionally described in patients with VADs, indicating effective device functionality. However, clinically significant hemolysis could be crucial in terms of prognosis, calling for prompt therapeutic actions. The absence of solid and widely approved diagnostic criteria for clinically significant hemolysis, render the utilization of hemolysis laboratory markers challenging. Hemolysis incidence varies (5%-18%) depending on definition and among different ...
Source: World Journal of Cardiology - July 26, 2020 Category: Cardiology Authors: Papanastasiou CA, Kyriakoulis KG, Theochari CA, Kokkinidis DG, Karamitsos TD, Palaiodimos L Tags: World J Cardiol Source Type: research

Mortality and morbidity in patients with atrial fibrillation and liver cirrhosis.
In this study, we examined morbidity and mortality of patients with concomitant AF and liver cirrhosis from the National Inpatient Sample database, the largest publicly available inpatient healthcare database in the United States. RESULTS: A total of 696937 patients with liver cirrhosis were included, 45745 of whom had concomitant AF (6.6%). Liver cirrhosis patients with AF had higher rates of in-hospital mortality (12.6% vs 10.3%, P
Source: World Journal of Cardiology - July 26, 2020 Category: Cardiology Authors: Darrat YH, Smer A, Elayi CS, Morales GX, Alqahtani F, Alkhouli M, Catanzaro J, Shah J, Salih M Tags: World J Cardiol Source Type: research

Sonographic muscle mass assessment in patients after cardiac surgery.
Abstract BACKGROUND: Patients undergoing cardiac surgery particularly those with comorbidities and frailty, experience frequently higher rates of post-operative morbidity, mortality and prolonged hospital length of stay. Muscle mass wasting seems to play important role in prolonged mechanical ventilation (MV) and consequently in intensive care unit (ICU) and hospital stay. AIM: To investigate the clinical value of skeletal muscle mass assessed by ultrasound early after cardiac surgery in terms of duration of MV and ICU length of stay. METHODS: In this observational study, we enrolled consecutively all pa...
Source: World Journal of Cardiology - July 26, 2020 Category: Cardiology Authors: Dimopoulos S, Raidou V, Elaiopoulos D, Chatzivasiloglou F, Markantonaki D, Lyberopoulou E, Vasileiadis I, Marathias K, Nanas S, Karabinis A Tags: World J Cardiol Source Type: research

Autonomic neurocardiogenic syndrome is stonewalled by the universal definition of myocardial infarction.
Abstract Myocardial infarction (MI) is defined as myocardial cell death due to prolonged myocardial ischemia. Clinically, troponin rise and/or fall have become the "defining feature of MI" according to the universal definition of MI (UD-MI). Takotsubo syndrome (TS) and TS-related disease conditions also cause troponin elevation with typical rise and/or fall pattern but through a mechanism other than coronary ischemia. By strict application of the clinical diagnostic criteria for type-1 MI, type-2 MI, type-3 MI, and MI with non-obstructive coronary arteries according to the UD-MI including the fourth one ...
Source: World Journal of Cardiology - June 26, 2020 Category: Cardiology Authors: Y-Hassan S Tags: World J Cardiol Source Type: research

Cardiovascular magnetic resonance in myocardial infarction with non-obstructive coronary arteries patients: A review.
Abstract The diagnosis of myocardial infarction with non-obstructive coronary arteries (MINOCA) necessitates documentation of an acute myocardial infarction (AMI), non-obstructive coronary arteries, using invasive coronary angiography or coronary computed tomography angiography and no clinically overt cause for AMI. Historically patients with MINOCA represent a clinical dilemma with subsequent uncertain clinical management. Differential diagnosis is crucial to choose the best therapeutic option for ischemic and non-ischemic MINOCA patients. Cardiovascular magnetic resonance (CMR) is able to analyze cardiac structu...
Source: World Journal of Cardiology - June 26, 2020 Category: Cardiology Authors: Gatti M, Carisio A, D'Angelo T, Darvizeh F, Dell'Aversana S, Tore D, Centonze M, Faletti R Tags: World J Cardiol Source Type: research

Diagnostic and treatment utility of echocardiography in the management of the cardiac patient.
CONCLUSION: The majority of physicians surveyed report the echocardiogram had only a mild effect on management with only 27.5% reporting a significant effect. However, the majority of physicians (83.3%) perceived an echocardiogram to be somewhat or entirely essential for management. Only 9.8% reported the echo led to further imaging. These insights into ordering physician reasoning should help guide better definition of the optimal and ideal use of echocardiography. PMID: 32774778 [PubMed] (Source: World Journal of Cardiology)
Source: World Journal of Cardiology - June 26, 2020 Category: Cardiology Authors: Khalili A, Drummond J, Ramjattan N, Zeltser R, Makaryus AN Tags: World J Cardiol Source Type: research

Intra-procedural arrhythmia during cardiac catheterization: A systematic review of literature.
Abstract BACKGROUND: Cardiac catheterization is among the most performed medical procedures in the modern era. There were sporadic reports indicating that cardiac arrhythmias are common during cardiac catheterization, and there are risks of developing serious and potentially life-threatening arrhythmias, such as sustained ventricular tachycardia (VT), ventricular fibrillation (VF) and high-grade conduction disturbances such as complete heart block (CHB), requiring immediate interventions. However, there is lack of systematic overview of these conditions. AIM: To systematically review existing literature and g...
Source: World Journal of Cardiology - June 26, 2020 Category: Cardiology Authors: Shaik FA, Slotwiner DJ, Gustafson GM, Dai X Tags: World J Cardiol Source Type: research

Tale of fat and fib - cardiac lipoma managed with radiofrequency ablation: A case report.
CONCLUSION: Benign fatty lesions in heart include solitary lipoma, lipomatous infiltration and lipomatous hypertrophy of interatrial septum. Although transvenous biopsy provides a definitive diagnosis, Cardiac MRI is superior to computed tomography and aids in differentiating benign from malignant lesions. Surgical excision of cardiac lipoma along with capsule and pedicle removal generally prevents recurrence, but with our patient's unusual tumor features and comorbidities proscribed a surgical approach. Symptom management with antiarrhythmics and ablation techniques were successfully utilized. PMID: 32774780 [PubMed]...
Source: World Journal of Cardiology - June 26, 2020 Category: Cardiology Authors: Nalluru SS, Nadadur S, Trivedi N, Trivedi S, Goyal S Tags: World J Cardiol Source Type: research

Exercise-induced torsades de pointes as an unusual presentation of cardiac sarcoidosis: A case report and review of literature.
CONCLUSION: Along an extensive review of the literature, this unusual case report highlights the importance of early detection of cardiac involvement of sarcoidosis, in order to avoid potential complications and increase survival. PMID: 32774781 [PubMed] (Source: World Journal of Cardiology)
Source: World Journal of Cardiology - June 26, 2020 Category: Cardiology Authors: Ghafari C, Vandergheynst F, Parent E, Tanaka K, Carlier S Tags: World J Cardiol Source Type: research

New guidelines for the diagnosis and management of pulmonary embolism: Key changes.
Abstract Pulmonary embolism (PE) is an important public health problem. In August 2019, the European Society of Cardiology in collaboration with the European Respiratory Society released new guidelines for the diagnosis and management of PE. We discuss the basic changes between these recent guidelines and the previous guidelines that were published in 2014. Regarding diagnosis, the new guidelines propose the use of an age-adjusted cut-off level of D-dimers instead of a fixed cut-off value. A D-dimer test adapted to clinical possibility should also be considered instead of fixed cut-off level of D-dimer. Detailed r...
Source: World Journal of Cardiology - May 26, 2020 Category: Cardiology Authors: Erythropoulou-Kaltsidou A, Alkagiet S, Tziomalos K Tags: World J Cardiol Source Type: research

Management of adults with coarctation of aorta.
Abstract Coarctation of the aorta (CoA) is a relatively common congenital cardiac defect often causing few symptoms and therefore can be challenging to diagnose. The hallmark finding on physical examination is upper extremity hypertension, and for this reason, CoA should be considered in any young hypertensive patient, justifying measurement of lower extremity blood pressure at least once in these individuals. The presence of a significant pressure gradient between the arms and legs is highly suggestive of the diagnosis. Early diagnosis and treatment are important as long-term data consistently demonstrate that pa...
Source: World Journal of Cardiology - May 26, 2020 Category: Cardiology Authors: Agasthi P, Pujari SH, Tseng A, Graziano JN, Marcotte F, Majdalany D, Mookadam F, Hagler DJ, Arsanjani R Tags: World J Cardiol Source Type: research

Nicotine-induced adrenal beta-arrestin1 upregulation mediates tobacco-related hyperaldosteronism leading to cardiac dysfunction.
CONCLUSION: Adrenal βarrestin1 upregulation is one of the mechanisms by which tobacco compounds, like nicotine, promote cardio-toxic hyperaldosteronism in vitro and in vivo. Thus, adrenal βarrestin1 represents a novel therapeutic target for tobacco-related heart disease prevention or mitigation. PMID: 32547713 [PubMed] (Source: World Journal of Cardiology)
Source: World Journal of Cardiology - May 26, 2020 Category: Cardiology Authors: Cora N, Ghandour J, Pollard CM, Desimine VL, Ferraino KE, Pereyra JM, Valiente R, Lymperopoulos A Tags: World J Cardiol Source Type: research

Access to smart devices and utilization of online health resources among older cardiac rehabilitation participants.
CONCLUSION: Among an older group of subjects attending CR, most have access to smart devices and do not perceive significant barriers to Internet use. Nonetheless, there was low utilization of health-related resources suggesting a need for targeted education in this patient population. PMID: 32547714 [PubMed] (Source: World Journal of Cardiology)
Source: World Journal of Cardiology - May 26, 2020 Category: Cardiology Authors: Saadi A, Kanmanthareddy A, Anantha-Narayanan M, Hardy K, Williams M, Alla VM Tags: World J Cardiol Source Type: research

Preoperative nuclear stress testing in the very old patient population.
Abstract BACKGROUND: Elderly patients awaiting moderate to high-risk surgery may undergo nuclear stress testing (NST) in order to evaluate their cardiovascular risk. The prognostic utility of such testing in the very elderly (≥ 85 years) has yet to be fully evaluated. Octogenarians and nonogenarians frequently have a number of concurrent conditions including a high rate of coronary disease, and therefore the prognostic value of NST for their preoperative risk assessment has been questioned. Our evaluation assesses the ability of nuclear stress testing to predict peri-operative cardiac outcomes in this patient p...
Source: World Journal of Cardiology - May 26, 2020 Category: Cardiology Authors: Makaryus AN, Makaryus JN, Diamond JA Tags: World J Cardiol Source Type: research

Incidental discovery of right ventricular lipoma in a young female associated with ventricular hyperexcitability: An imaging multimodality approach.
CONCLUSION: Multimodal cardiac imaging and histopathological examination are required for a definitive diagnosis. The therapeutic approach depends on clinical presentation. PMID: 32547716 [PubMed] (Source: World Journal of Cardiology)
Source: World Journal of Cardiology - May 26, 2020 Category: Cardiology Authors: Elenizi K, Matta A, Alharthi R, Campelo-Parada F, Lhermusier T, Bouisset F, Elbaz M, Carrié D, Roncalli J Tags: World J Cardiol Source Type: research

Management of hypertension in COVID-19.
Abstract The ACE2 receptor plays a central role in severe acute respiratory syndrome coronavirus 2 host cell entry and propagation. It has therefore been postulated that angiotensin converting enzyme inhibitors and angiotensin receptor blockers may upregulate ACE2 expression and thus increase susceptibility to infection. We suggest that alternative anti-hypertensive agents should be preferred among individuals who may be exposed to this increasingly common and potentially lethal virus. PMID: 32547717 [PubMed] (Source: World Journal of Cardiology)
Source: World Journal of Cardiology - May 26, 2020 Category: Cardiology Authors: Antwi-Amoabeng D, Beutler BD, Moody AE, Kanji Z, Gullapalli N, Rowan CJ Tags: World J Cardiol Source Type: research

Role of gut microbiota in cardiovascular diseases.
This article reviews the normal function and composition of the gut microbiome, mechanisms leading to the leaky gut syndrome, its mechanistic link to CVD and potential novel therapeutic approaches aimed towards restoring gut microbiome and CVD prevention. As CVD is the leading cause of deaths globally, investigating the gut microbiota as a locus of intervention presents a novel and clinically relevant avenue for future research. PMID: 32431782 [PubMed] (Source: World Journal of Cardiology)
Source: World Journal of Cardiology - April 26, 2020 Category: Cardiology Authors: Novakovic M, Rout A, Kingsley T, Kirchoff R, Singh A, Verma V, Kant R, Chaudhary R Tags: World J Cardiol Source Type: research

Do age-associated changes of voltage-gated sodium channel isoforms expressed in the mammalian heart predispose the elderly to atrial fibrillation?
Abstract Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide. The prevalence of the disease increases with age, strongly implying an age-related process underlying the pathology. At a time when people are living longer than ever before, an exponential increase in disease prevalence is predicted worldwide. Hence unraveling the underlying mechanics of the disease is paramount for the development of innovative treatment and prevention strategies. The role of voltage-gated sodium channels is fundamental in cardiac electrophysiology and may provide novel insights into the arrhythmogenesis of AF. Na...
Source: World Journal of Cardiology - April 26, 2020 Category: Cardiology Authors: Isaac E, Cooper SM, Jones SA, Loubani M Tags: World J Cardiol Source Type: research

Comparative assessment of clinical profile and outcomes after primary percutaneous coronary intervention in young patients with single vs multivessel disease.
Abstract BACKGROUND: Even though percutaneous coronary intervention (PCI) improved the survival of patients with acute myocardial infarction, still multivessel coronary artery disease remains an important factor burdening prognosis and it is being associated with a worse prognosis compared to single-vessel disease (SVD). AIM: To compare the clinical profile and outcomes after the primary PCI in young patients with SVD vs multivessel disease (MVD). METHODS: The retrospective cohort of patients were divided into two groups: SVD and MVD group. The study population consisted of both male and female young (&l...
Source: World Journal of Cardiology - April 26, 2020 Category: Cardiology Authors: Muhammad AS, Ashraf T, Mir A, Alishan S, Farooq F, Ammar A, Karim M, Rizvi SNH, Saghir T, Sial JA, Khan NU Tags: World J Cardiol Source Type: research

Autonomic laterality in caloric vestibular stimulation.
Abstract BACKGROUND: Caloric stimulation of the vestibular system is associated with autonomic response. The lateralization in the nervous system activities also involves the autonomic nervous system. AIM: To compare the effect of the right and left ear caloric test on the cardiac sympathovagal tone in healthy persons. METHODS: This self-control study was conducted on 12 healthy male volunteers. The minimal ice water caloric test was applied for vestibular stimulation. This was done by irrigating 1 milliliter of 4 ± 2 °C ice water into the external ear canal in 1 s. In each experiment, only on...
Source: World Journal of Cardiology - April 26, 2020 Category: Cardiology Authors: Aghababaei Ziarati M, Taziki MH, Hosseini SM Tags: World J Cardiol Source Type: research

Subclavian Impella 5.0 to the rescue in a non-ST elevation myocardial infarction patient requiring unprotected left main rotablation: A case report.
CONCLUSION: This case highlights the need for cross-specialty collaborations in such high-risk cases were alternative access is needed for insertion of large bore mechanical circulatory support devices. PMID: 32431786 [PubMed] (Source: World Journal of Cardiology)
Source: World Journal of Cardiology - April 26, 2020 Category: Cardiology Authors: Panoulas V, Monteagudo-Vela M, Kalogeras K, Simon A Tags: World J Cardiol Source Type: research

Cardiovascular surgery in Turner syndrome - early outcome and long-term follow-up.
CONCLUSION: Cardiovascular surgery is associated with 8% early mortality given the medical complexity of TS patients. Those who survive to dismissal have good survival. Later cardiovascular reoperations are not rare. PMID: 32280428 [PubMed] (Source: World Journal of Cardiology)
Source: World Journal of Cardiology - March 26, 2020 Category: Cardiology Authors: Fuchs MM, Attenhofer Jost CH, Said SM, Hagler DJ, Connolly HM, Dearani JA, Egbe AC Tags: World J Cardiol Source Type: research

Demystifying airline syncope.
Abstract Syncope forms a major part of medical in-flight emergencies contributing one-in-four in-flight medical events accounting to 70% of flight diversions. In such patients, it is important to elucidate the pathophysiology of syncope prior to diversion. Postural hypotension is the most common etiology of in-flight syncopal events. However, individuals without any underlying autonomic dysfunction can still experience syncope from hypoxia also known as airline syncope. Initial steps in managing such patients include positioning followed by the airway, breathing and circulation of resuscitation. These intervention...
Source: World Journal of Cardiology - March 26, 2020 Category: Cardiology Authors: Kingsley T, Kirchoff R, Newman JS, Chaudhary R Tags: World J Cardiol Source Type: research

Carbon dioxide-angiography for patients with peripheral arterial disease at risk of contrast-induced nephropathy.
Abstract Patients with peripheral arterial disease (PAD) and critical limb ischemia are at risk for limb amputation and require urgent management to restore blood flow. Patients with PAD often have several comorbidities, including chronic kidney disease, diabetes mellitus, and hypertension. Diagnostic and interventional angiography using iodinated contrast agents provides excellent image resolution but can be associated with contrast-induced nephropathy (CIN). The use of carbon dioxide (CO2) as a contrast agent reduces the volume of iodine contrast required for angiography and reduces the incidence of CIN. However...
Source: World Journal of Cardiology - February 26, 2020 Category: Cardiology Authors: Gupta A, Dosekun AK, Kumar V Tags: World J Cardiol Source Type: research

Plaque herniation after stenting the culprit lesion with myocardial bridging in ST elevation myocardial infarction: A case report.
CONCLUSION: Plaque herniation or prolapse after stenting a MB segment in STEMI is a potential etiology for acute stent failure. PMID: 32184977 [PubMed] (Source: World Journal of Cardiology)
Source: World Journal of Cardiology - February 26, 2020 Category: Cardiology Authors: Ma J, Gustafson GM, Dai X Tags: World J Cardiol Source Type: research

Is there a role for ischemia detection after an acute myocardial infarction?
Abstract Coronary angiography and eventual revascularization have become the most common approaches for patients with acute coronary syndromes. Ischemia detection in this scenario is usually regarded as unnecessary for most of the patients. In fact, current guidelines recommend complete revascularization for patients with multivessel disease in the context of ST-elevation myocardial infarction, although it is in contrast with previous recommendations. However, some recent data suggested that ischemia could have a role for the decision of revascularization in these patients. The CROSS-AMI study randomized patients ...
Source: World Journal of Cardiology - January 26, 2020 Category: Cardiology Authors: Peteiro J, Bouzas-Mosquera A Tags: World J Cardiol Source Type: research

Diagnosis and treatment of heart failure with preserved left ventricular ejection fraction.
Abstract Nearly six million people in United States have heart failure. Fifty percent of these people have normal left ventricular (LV) systolic heart function but abnormal diastolic function due to increased LV myocardial stiffness. Most commonly, these patients are elderly women with hypertension, ischemic heart disease, atrial fibrillation, obesity, diabetes mellitus, renal disease, or obstructive lung disease. The annual mortality rate of these patients is 8%-12% per year. The diagnosis is based on the history, physical examination, laboratory data, echocardiography, and, when necessary, by cardiac catheteriza...
Source: World Journal of Cardiology - January 26, 2020 Category: Cardiology Authors: Henning RJ Tags: World J Cardiol Source Type: research

Radial artery access site complications during cardiac procedures, clinical implications and potential solutions: The role of nitric oxide.
Abstract Percutaneous coronary intervention for the treatment of coronary artery disease is most commonly performed in the UK through the radial artery, as this is safer than the femoral approach. However, despite improvements in technology and techniques, complications can occur. The most common complication, arterial spasm, can cause intense pain and, in some cases, procedural failure. The incidence of spasm is dependent on several variables, including operator experience, artery size, and equipment used. An anti-spasmolytic cocktail can be applied to reduce spasm, which usually includes an exogenous nitric oxid...
Source: World Journal of Cardiology - January 26, 2020 Category: Cardiology Authors: Coghill EM, Johnson T, Morris RE, Megson IL, Leslie SJ Tags: World J Cardiol Source Type: research

Impact of training specificity on exercise-induced cardiac troponin elevation in professional athletes: A pilot study.
CONCLUSION: In professional athletes adapted to high-intensity intermittent exercise, hs-cTnT was significantly elevated after intermittent but not continuous exercise. This principle of specificity training should be considered when designing future studies to avoid misinterpretation of hs-cTnT elevation. PMID: 31984126 [PubMed] (Source: World Journal of Cardiology)
Source: World Journal of Cardiology - January 26, 2020 Category: Cardiology Authors: Wedin JO, Nyberg NS, Henriksson AE Tags: World J Cardiol Source Type: research

Prognostic impact of body mass index on in-hospital bleeding complications after ST-segment elevation myocardial infarction.
;re L Abstract BACKGROUND: ST-elevation myocardial infarction (STEMI) remains a major cause of mortality despite early revascularization and optimal medical therapy. Tailoring individual management by considering patients' specificities may help in improving post-STEMI survival. AIM: To evaluate whether in-hospital bleeding complications may be involved in post STEMI prognosis among overweight patients. METHODS: We prospectively included 2070 patients with a STEMI between January 2005 and December 2012 in the French observational cohort, "Registre d'Infarctus Maine-Anjou". Bleeding Academic Res...
Source: World Journal of Cardiology - January 26, 2020 Category: Cardiology Authors: Ingremeau D, Grall S, Valliet F, Desprets L, Prunier F, Furber A, Bière L Tags: World J Cardiol Source Type: research

Phrenic nerve displacement by intrapericardial balloon inflation during epicardial ablation of ventricular tachycardia: Four case reports.
CONCLUSION: PN injury can occur as one of the complications following epicardial VT ablation procedures, and may prevent successful ablation of these arrhythmias. PN displacement by using large balloon catheters into the epicardial space seems to be feasible and reproducible, avoid procedure-related morbidity, and improve ablation success when performed in selected centers and by experienced operators. PMID: 31984128 [PubMed] (Source: World Journal of Cardiology)
Source: World Journal of Cardiology - January 26, 2020 Category: Cardiology Authors: Conti S, Bonomo V, Taormina A, Giordano U, Sgarito G Tags: World J Cardiol Source Type: research

Salmonella typhimurium myopericarditis: A case report and review of literature.
CONCLUSION: Myopericarditis is a rare, but potentially serious complication of NTS infection, associated with an increased morbidity and mortality. PMID: 31984129 [PubMed] (Source: World Journal of Cardiology)
Source: World Journal of Cardiology - January 26, 2020 Category: Cardiology Authors: Jin D, Kao CY, Darby J, Palmer S Tags: World J Cardiol Source Type: research

Pericardial decompression syndrome: A comprehensive review.
Abstract Pericardial decompression syndrome (PDS) is an infrequent, life-threatening complication following pericardial drainage for cardiac tamponade physiology. PDS usually develops after initial clinical improvement following pericardiocentesis and is significantly underreported and may be overlooked in the clinical practice. Although the precise mechanisms resulting in PDS are not well understood, this seems to be highly associated with patients who have some underlying ventricular dysfunction. Physicians performing pericardial drainage should be mindful of the risk factors associated with the procedure includ...
Source: World Journal of Cardiology - December 26, 2019 Category: Cardiology Authors: Prabhakar Y, Goyal A, Khalid N, Sharma N, Nayyar R, Spodick DH, Chhabra L Tags: World J Cardiol Source Type: research

Red blood cell distribution width: A marker of anisocytosis potentially associated with atrial fibrillation.
Abstract The incorporation of biomarkers in the actually used risk scores seem to be helpful for early identifying atrial fibrillation (AF) patients at higher risk. The aim of this critical review of the scientific literature is to investigate the potential clinical significance of red blood cell distribution width (RDW) in AF. A systematic electronic search was carried out to identify all articles describing an epidemiological association between RDW and AF in adult human populations. Data abstraction was conducted on a final number of 35 articles (13 cross-sectional, 12 prospective and 10 retrospective studies)....
Source: World Journal of Cardiology - December 26, 2019 Category: Cardiology Authors: Lippi G, Cervellin G, Sanchis-Gomar F Tags: World J Cardiol Source Type: research

Myocardial infarction with non-obstructive coronary arteries: A comprehensive review and future research directions.
ey JR Abstract Acute coronary syndromes constitute a variety of myocardial injury presentations that include a subset of patients presenting with myocardial infarction with non-obstructive coronary arteries (MINOCA). This acute coronary syndrome differs from type 1 myocardial infarction (MI) regarding patient characteristics, presentation, physiopathology, management, treatment, and prognosis. Two-thirds of MINOCA subjects present ST-segment elevation; MINOCA patients are younger, are more often female and tend to have fewer cardiovascular risk factors. Moreover, MINOCA is a working diagnosis, and defining the aet...
Source: World Journal of Cardiology - December 26, 2019 Category: Cardiology Authors: Vidal-Perez R, Abou Jokh Casas C, Agra-Bermejo RM, Alvarez-Alvarez B, Grapsa J, Fontes-Carvalho R, Rigueiro Veloso P, Garcia Acuña JM, Gonzalez-Juanatey JR Tags: World J Cardiol Source Type: research

Left recurrent laryngeal nerve palsy following aortic arch stenting: A case report.
CONCLUSION: Left recurrent laryngeal nerve palsy is a rare complication of aortic arch stenting not previously reported. PMID: 31908731 [PubMed] (Source: World Journal of Cardiology)
Source: World Journal of Cardiology - December 26, 2019 Category: Cardiology Authors: Fürniss HE, Hummel J, Stiller B, Grohmann J Tags: World J Cardiol Source Type: research

Novel lipid-modifying therapies addressing unmet needs in cardiovascular disease.
Abstract Cardiovascular disease (CVD) remains a major cause of morbidity and mortality worldwide. Currently, it is well established that dyslipidemia is one of the major risk factors leading to the development of atherosclerosis and CVD. Statins remain the standard-of-care in the treatment of hypercholesterolemia and their use has significantly reduced cardiovascular morbidity and mortality. In addition, recent advances in lipid-modifying therapies, such as the development of proprotein convertase subtilisin/kexin type 9 inhibitors, have further improved cardiovascular outcomes in patients with hypercholesterolemi...
Source: World Journal of Cardiology - November 26, 2019 Category: Cardiology Authors: Kosmas CE, Sourlas A, Silverio D, Montan PD, Guzman E Tags: World J Cardiol Source Type: research

Multi-modality imaging in transthyretin amyloid cardiomyopathy.
Abstract Transthyretin amyloid (TTR) cardiomyopathy is a disease of insidious onset, which is often accompanied by debilitating neurological and/or cardiac complications. The true prevalence is not fully known due to its elusive presentation, being often under-recognized and usually diagnosed only late in its natural history and in older patients. Because of this, effective treatment options are usually precluded by multiple comorbidities and frailty associated with such patients. Therefore, high clinical suspicion with earlier and better detection of this disease is needed. In this review, the novel applications ...
Source: World Journal of Cardiology - November 26, 2019 Category: Cardiology Authors: Traynor BP, Shamsi A, Voon V Tags: World J Cardiol Source Type: research

Management of atherosclerotic plaque in left internal mammary artery graft five years after angiographic patency: A case report.
CONCLUSION: This case highlights the rapid and late development of atherosclerosis in a graft 5 years after documented patency and the importance for consideration of expectant thrombus management. PMID: 31798794 [PubMed] (Source: World Journal of Cardiology)
Source: World Journal of Cardiology - November 26, 2019 Category: Cardiology Authors: Nandal S, Narayan O, Barlis P, Ponnuthurai FA Tags: World J Cardiol Source Type: research