Phosphate binder pill burden, adherence, and serum phosphorus control among hemodialysis patients converting to sucroferric oxyhydroxide.
We examined changes in phosphate binder pill burden, medication possession ratio (MPR), and phosphorus control among in-center hemodialysis (ICHD) patients converting to SO from another phosphate binder as part of routine care. Materials and methods: Patients included in this retrospective analysis (N=490) were ≥18 years old, received ICHD at a large dialysis organization (LDO), and were enrolled in the LDO's pharmacy service. Patients converting to SO were those who had supply of another phosphate binder, received a first prescription fill for SO, and subsequently did not refill the non-SO phosphate binder. Patient...
Source: International Journal of Nephrology and Renovascular Disease - February 20, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

HO-1 concentrations 24 hours after cardiac surgery are associated with the incidence of acute kidney injury: a prospective cohort study.
Conclusion: The association of the second HO-1 burst 24 hours after CBP might help to distinguish between the causality of AKI in patients undergoing CBP, thus helping to adapt patient stratification and management. PMID: 30774413 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - February 20, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

The potential diagnostic utility of coexpression of Ki-67 and P53 in the renal biopsy in pediatric lupus nephritis.
Authors: Rahbar MH, Rahbar MR, Mardanpour N, Mardanpour S Abstract Background: The proliferative activity as well as apoptosis has been suggested to play a role in the pathogenesis of lupus nephritis (LN). The aim of the study was to investigate the coexpression of Ki-67-triggered marked proliferation and P53-induced apoptosis in renal biopsy of childhood lupus nephritis (cLN) and to compare the coexpression of proliferative and apoptotic indices between different subgroups and clinicopathologic patterns of renal disease. Methods: Renal biopsy specimens of 33 children with lupus nephritis (LN) and 10 healthy su...
Source: International Journal of Nephrology and Renovascular Disease - December 29, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Self-management and associated factors among patients with end-stage renal disease undergoing hemodialysis at health facilities in Addis Ababa, Ethiopia.
Authors: Gela D, Mengistu D Abstract Introduction: Patients with end-stage renal disease (ESRD) face multifaceted problems arising from complications of the disease and dialysis that require consistent and, effective self-management from the patients' side, on top of the management offered by health care professionals. However, little is known about the level of self-management and influencing factors among patients with ESRD undergoing hemodialysis in the study area. Therefore, the aim of this study was to assess self-management and associated factors of patients with ESRD undergoing hemodialysis at health facilit...
Source: International Journal of Nephrology and Renovascular Disease - December 22, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Acute kidney injury among nonagenarians in Jordan: a retrospective case-control study.
Conclusion: AKI is common in nonagenarians. It was associated with increased length of hospital stays and increased risk for mortality. PMID: 30555251 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - December 19, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Evaluation of a protocol for coronary artery disease investigation in asymptomatic elderly hemodialysis patients.
Conclusion: In older patients on renal replacement therapy, the prevalence of CAD was high, but coronary investigation was not useful as a risk stratification tool and also resulted in a rather small proportion of patients eligible for intervention. Therefore, in the elderly, coronary investigation should not be considered routine in asymptomatic patients. PMID: 30532578 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - December 13, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Antineutrophil cytoplasmic antibody-associated vasculitis, update on molecular pathogenesis, diagnosis, and treatment.
Authors: Arman F, Barsoum M, Selamet U, Shakeri H, Wassef O, Mikhail M, Rastogi A, Hanna RM Abstract Circulating antineutrophil cytoplasmic antibodies (ANCAs) are the central pathogenic mechanism for a group of systemic and renal syndromes called the ANCA-associated vasculitis (AAV). The nomenclature has changed from eponymous labeling to granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, and microscopic polyangiitis. These syndromes predominantly affect the pulmonary and renal systems. We also review the molecular pathology behind ANCAs and associated antigens and infections. Various ...
Source: International Journal of Nephrology and Renovascular Disease - December 13, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Successful salvage of allograft dysfunction triggered by transplant renal vein thrombosis immediately after kidney transplantation: a case report.
Conclusion: Although TRVT is induced by multiple factors, an accurate diagnosis is often difficult. Understanding these factors, including obesity, and considering TRVT as a cause of allograft dysfunction are important during the pre-, peri-, and postoperative periods. Knowledge of TRVT can lead to early and accurate diagnosis and intervention, resulting in better outcomes for the patients with allograft dysfunction. PMID: 30538528 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - December 13, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Bartter syndrome: causes, diagnosis, and treatment.
Authors: Cunha TDS, Heilberg IP Abstract Bartter syndrome is an inherited renal tubular disorder caused by a defective salt reabsorption in the thick ascending limb of loop of Henle, resulting in salt wasting, hypokalemia, and metabolic alkalosis. Mutations of several genes encoding the transporters and channels involved in salt reabsorption in the thick ascending limb cause different types of Bartter syndrome. A poor phenotype-genotype relationship due to the interaction with other cotransporters and different degrees of compensation through alternative pathways is currently reported. However, phenotypic identific...
Source: International Journal of Nephrology and Renovascular Disease - December 8, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Nocturnal blood pressure decrease in patients with chronic kidney disease and in healthy controls - significance of obstructive sleep apnea and renal function.
Authors: Hornstrup BG, Gjoerup PH, Wessels J, Lauridsen TG, Pedersen EB, Bech JN Abstract Background: Chronic kidney disease (CKD) is often associated with a blunted nocturnal BP decrease and OSA. However, it is not fully clear whether a relationship exists between reduction in renal function and obstructive sleep apnea (OSA) on the one hand and relative nocturnal BP decrease in CKD patients on the other. The aim of this study was to investigate the association between nocturnal BP decrease and renal function, the degree of OSA, vasoactive hormones, and renal sodium handling in CKD3-4 patients and healthy age-match...
Source: International Journal of Nephrology and Renovascular Disease - December 6, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Renal transplantation in patients with Alport syndrome: patient selection, outcomes, and donor evaluation.
Authors: Kashtan CE Abstract Alport syndrome is an inherited disorder of basement membrane collagen IV that frequently results in end-stage renal disease. Patients with Alport syndrome who undergo renal transplantation have generally excellent outcomes. Posttransplant antiglomerular basement membrane nephritis is a rare complication of renal transplantation for Alport syndrome. Because Alport syndrome is a genetic disorder, potential related donors must be carefully evaluated in order to minimize harm. PMID: 30410383 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - November 11, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Low aquaporin-2 excretion in the nephrotic syndrome: an escape from the vasopressin regulating effect.
Authors: Brovko M, Kozlovskaya L, Pulin A, Moiseev S, Sholomova V, Shchekochikhin D, Gognieva D, Milovanova L, Fomin V Abstract Purpose: Experimental studies suggest that the nephrotic syndrome is associated with "vasopressin escape", characterized by low aquaporin-2 (AQP2) expression in the collecting duct despite high vasopressin secretion. We investigated this phenomenon in patients with the nephrotic syndrome. Patients and methods: We recruited 47 patients with proteinuric kidney disease who were distributed into the following four groups: 1) nephrotic syndrome with kidney dysfunction (n=10); 2) n...
Source: International Journal of Nephrology and Renovascular Disease - November 11, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Serial changes in vessel walls of renal arteries after catheter-based renal artery denervation: insights from volumetric computed tomography analysis.
Conclusion: Change in vessel wall was greater within the segments receiving renal artery denervation. Baseline VWV predicted its substantial increase after the procedure. These observations suggest that atheroma burden within the renal arteries is a potential contributing factor to vascular changes after renal sympathetic denervation. PMID: 30310302 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - October 13, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Clinical value of a serum anti-PLA2R antibody in the diagnosis and monitoring of primary membranous nephropathy in adults.
Authors: Wu X, Liu L, Guo Y, Yang L Abstract Objective: To compare the positive rate of anti-PLA2R antibodies in patients with primary membranous nephropathy (PMN), secondary membranous nephropathy (SMN), and non-membrane nephropathy (non-MN); evaluate serum anti-PLA2R antibodies in the diagnosis of PMN; quantify the serum anti-PLA2R antibody levels during the treatment of PMN patients; and evaluate the clinical value of monitoring changes in serum anti-PLA2R antibody quantification levels. Methods: The kidney tissue was collected by kidney biopsy. The expression of PLA2R in glomeruli was detected by immunofluo...
Source: International Journal of Nephrology and Renovascular Disease - October 7, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Renal replacement therapy in patients with acute respiratory distress syndrome: a single-center retrospective study.
Conclusion: Timing of RRT initiation was not associated with a survival benefit. Prospective study in the utilization and outcomes of RRT in ARDS could assist in optimizing its usage in this population. PMID: 30288081 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - October 7, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Inflammatory milieu in contrast-induced nephropathy: a prospective single-center study.
Conclusion: Serum level of IL-33 was a significant predictor for development of CIN. Good clinical judgment and high serum levels of IL-33 may stratify patients into low and high risk for CIN. PMID: 30147351 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - August 28, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Acute kidney injury in elderly patients: narrative review on incidence, risk factors, and mortality.
Authors: Yokota LG, Sampaio BM, Rocha EP, Balbi AL, Sousa Prado IR, Ponce D Abstract Acute kidney injury (AKI) is characterized by a sudden renal dysfunction with consequent increase of nitrogenous products, hydroelectrolytic and acid-base disorders. Its prevalence is high in hospitalized populations (4.9%-7.2%), especially in intensive care units (ICUs). Despite all the technical and therapeutic advances that have occurred in the last few decades, the overall mortality of AKI patients remains high, reaching 80% in ICU patients. Several conditions predispose a patient to progress with AKI, including age, sepsis, su...
Source: International Journal of Nephrology and Renovascular Disease - August 28, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Takayasu's disease effects on the kidneys: current perspectives.
Authors: Li Cavoli G, Mulè G, Vallone MG, Caputo F Abstract Takayasu arteritis (TA) is a chronic vasculitis disease of unknown etiology. Clinically significant renal disease is relatively common, and renovascular hypertension is the major renal problem. The assessment of TA activity is usually challenging because vascular inflammation may progress to fixed vascular injury without findings of active disease. Until now, the best therapeutic options have not been identified. This review highlights the current perspectives of renal involvement in TA. PMID: 30147353 [PubMed] (Source: International Journal of ...
Source: International Journal of Nephrology and Renovascular Disease - August 28, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Effects of tolvaptan on renal function in chronic kidney disease patients with volume overload.
Authors: Suzuki S, Hanafusa N, Kubota K, Tsuchiya K, Nitta K Abstract Background: Fluid overload in chronic kidney disease (CKD) is generally controlled by diuretics, with potentially harmful effects on renal function. The efficacy of tolvaptan, a vasopressin V2-receptor antagonist and aquaretic, has not been evaluated for fluid control in CKD with reduced renal function. Methods: Each patient from a group of 24 CKD patients on tolvaptan 15 mg/d plus conventional diuretics (T group) was matched by age and sex with a patient from a group of 24 CKD patients on conventional nonaquaretic diuretics alone not associa...
Source: International Journal of Nephrology and Renovascular Disease - August 28, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Relationship of inferior vena cava collapsibility to ultrafiltration volume achieved in critically ill hemodialysis patients.
Authors: Kaptein MJ, Kaptein JS, Oo Z, Kaptein EM Abstract Background: Ultrasound (US) assessment of intravascular volume may improve volume management of dialysis patients. We investigated the relationship of intravascular volume evaluated by inferior vena cava (IVC) US to net volume changes with intermittent hemodialysis (HD) in critically ill patients. Methods: A retrospective cohort of 113 intensive care unit patients in 244 encounters had clinical assessment of intravascular volume followed by US of respiratory/ventilatory variation of IVC diameter, and had HD within 24 h. IVC collapsibility index (IVC CI)...
Source: International Journal of Nephrology and Renovascular Disease - August 10, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Atherosclerotic vascular disease and its correlates in stable black South African kidney transplant recipients.
Authors: Oguntola SO, Hassan MO, Duarte R, Dix-Peek T, Dickens C, Olorunfemi G, Vachiat A, Paget G, Manga P, Naicker S Abstract Background: Despite remarkable improvement in renal function attributable to kidney transplantation, the burden of cardiovascular disease (CVD) among kidney transplant recipients (KTRs) remains high in the post-transplant period. Aggressive use of statins in KTRs may make lipoprotein ratios correlate better with atherosclerotic vascular disease (AsVD) when compared with traditional lipid profile parameters. We therefore evaluated the clinical and echocardiographic correlates of AsVD among ...
Source: International Journal of Nephrology and Renovascular Disease - July 25, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Peritoneal dialysis-related peritonitis: challenges and solutions.
Authors: Salzer WL Abstract Peritoneal dialysis is an effective treatment modality for patients with end-stage renal disease. The relative use of peritoneal dialysis versus hemodialysis varies widely by country. Data from a 2004 survey reports the percentage of patients with end-stage renal disease treated with peritoneal dialysis to be 5%-10% in economically developed regions like the US and Western Europe to as much as 75% in Mexico. This disparity is probably related to the availability and access to hemodialysis, or in some cases patient preference for peritoneal over hemodialysis. Peritoneal dialysis-related p...
Source: International Journal of Nephrology and Renovascular Disease - June 22, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Prevalence of chronic kidney disease in Nigeria: systematic review of population-based studies.
Conclusion: The prevalence of CKD was high but variable in Nigeria, influenced by the equation used to estimate the GFR. MDRD and CKD-EPI results are agreeable. There is a need for more population-based studies, with emphasis on repeating the GFR estimation after 3 months in subjects with GFR
Source: International Journal of Nephrology and Renovascular Disease - June 5, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Smoking and outcomes in kidney transplant recipients: a post hoc survival analysis of the FAVORIT trial.
Authors: Weinrauch LA, Claggett B, Liu J, Finn PV, Weir MR, Weiner DE, D'Elia JA Abstract Background: Tobacco use remains an international health problem with between 10% and 40% of adults currently using tobacco. Given the rising number of patients either awaiting or having received a kidney transplant and the absence of smoking cessation as the criterion for transplantation in guidelines, we explored the association between smoking status and clinical outcomes in kidney transplant recipients. Patients and methods: In this post hoc analysis of the Folic Acid for Vascular Outcome Reduction in Transplant trial, ...
Source: International Journal of Nephrology and Renovascular Disease - May 16, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Prediction of acute kidney injury in cirrhotic patients: a new score combining renal, liver and inflammatory markers.
Authors: Gameiro J, Agapito Fonseca J, Monteiro Dias J, Melo MJ, Jorge S, Velosa J, Lopes JA Abstract Introduction: Acute kidney injury (AKI) is common in hospitalized patients with cirrhosis and is associated with poor prognosis. A risk prediction score combining values easily measured at admission could be valuable to stratify patients for prevention, monitoring and early intervention, ultimately improving patient care and outcomes. The aim of this study was to develop a risk score for AKI in a cohort of cirrhotic patients. Patients and methods: We cross-examined the data from a retrospective analysis of 186 ...
Source: International Journal of Nephrology and Renovascular Disease - May 9, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Primary IgA nephropathy: current challenges and future prospects.
Authors: Penfold RS, Prendecki M, McAdoo S, Tam FW Abstract IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide, exhibiting a variable clinical and pathological course and significantly contributing to the global burden of chronic kidney disease and end-stage renal disease. Current standards of care focus on optimization of antihypertensive and antiproteinuric therapies (typically renin- angiotensin system blockade) to reduce disease progression. Much recent attention has focused on whether additional immunosuppression confers better outcomes than supportive management alone, and ...
Source: International Journal of Nephrology and Renovascular Disease - April 28, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

FGF23 modulates the effects of erythropoietin on gene expression in renal epithelial cells.
Conclusion: Our results suggest cross talk between erythropoietin and FGF23 signaling in the regulation of renal epithelial cells. PMID: 29670389 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - April 21, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Unmet service needs evaluated by case managers among disabled patients on hemodialysis in Japan.
Conclusion: CMs need to monitor unmet needs after coordinating HCBS for DPHD and need to encourage HBCS use among patients with impaired cognitive function and caregivers with heavier caregiving burdens. PMID: 29588610 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - March 30, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Anxiety and depression in patients with end-stage renal disease: impact and management challenges - a narrative review.
Authors: Goh ZS, Griva K Abstract Psychiatric disorders commonly co-exist with the diagnosis of chronic kidney disease (CKD). Research on depression and CKD has increased to a great extent. Multiple studies have demonstrated that depression is more prevalent in CKD and that end-stage renal disease is a robust risk factor for adverse outcomes such as hospitalization and mortality, yet these are often underdiagnosed or untreated. This review provides a selective overview on the prevalence rates of depression and anxiety in patients with CKD and across renal replacement therapies, the factors most consistently associa...
Source: International Journal of Nephrology and Renovascular Disease - March 27, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

BOLD magnetic resonance imaging in nephrology.
Authors: Hall ME, Jordan JH, Juncos LA, Hundley WG, Hall JE Abstract Magnetic resonance (MR) imaging, a non-invasive modality that provides anatomic and physiologic information, is increasingly used for diagnosis of pathophysiologic conditions and for understanding renal physiology in humans. Although functional MR imaging methods were pioneered to investigate the brain, they also offer powerful techniques for investigation of other organ systems such as the kidneys. However, imaging the kidneys provides unique challenges due to potential complications from contrast agents. Therefore, development of non-contrast te...
Source: International Journal of Nephrology and Renovascular Disease - March 27, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

The importance of the thick ascending limb of Henle's loop in renal physiology and pathophysiology.
Authors: Zacchia M, Capolongo G, Rinaldi L, Capasso G Abstract The thick ascending limb (TAL) of Henle's loop is a crucial segment for many tasks of the nephron. Indeed, the TAL is not only a mainstay for reabsorption of sodium (Na+), potassium (K+), and divalent cations such as calcium (Ca2+) and magnesium (Mg2+) from the luminal fluid, but also has an important role in urine concentration, overall acid-base homeostasis, and ammonia cycle. Transcellular Na+ transport along the TAL is a prerequisite for Na+, K+, Ca2+, Mg2+ homeostasis, and water reabsorption, the latter through its contribution in the generation of...
Source: International Journal of Nephrology and Renovascular Disease - March 3, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Is the light at the end of the tunnel nigh? A review of ADPKD focusing on the burden of disease and tolvaptan as a new treatment.
In this report, we present a detailed review of ADPKD, with a particular focus on its major economic, psychological, and social burden in affected patients. Treatment of this disease has been based on prophylactic and supportive measures. However, in recent years, new drugs have emerged as promising agents that may retard the progression of ADPKD, such as tolvaptan. In this report, we provide an in-depth discussion of tolvaptan, which has shown an effect in decreasing annual total kidney volume growth and renal function decline, thus slowing disease progression. The mechanism of action, side effects, and available data on ...
Source: International Journal of Nephrology and Renovascular Disease - February 15, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Managing hyperparathyroidism in hemodialysis: role of etelcalcetide.
Authors: Eidman KE, Wetmore JB Abstract Secondary hyperparathyroidism (SHPT) is common in patients receiving maintenance hemodialysis and is associated with adverse outcomes. Currently, SHPT is managed by reducing circulating levels of phosphate with oral binders and parathyroid hormone (PTH) with vitamin D analogs and/or the calcimimetic cinacalcet. Etelcalcetide, a novel calcimimetic administered intravenously (IV) at the end of a hemodialysis treatment session, effectively reduces PTH in clinical trials when given thrice weekly. Additional clinical effects include reductions in circulating levels of phosphate an...
Source: International Journal of Nephrology and Renovascular Disease - February 15, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Tolvaptan in the treatment of autosomal dominant polycystic kidney disease: patient selection and special considerations.
Authors: Sans-Atxer L, Joly D Abstract Standard of care therapies for autosomal dominant polycystic kidney disease (ADPKD) may limit morbidity and mortality due to disease-related complications, but they do not delay disease progression. Tolvaptan, a selective vasopressin V2 receptor antagonist, delays the increase in kidney volume (a surrogate marker for disease progression), slows the decline in renal function, and reduces pain in ADPKD patients with relatively preserved renal function. The most common adverse events of tolvaptan are linked to its aquaretic effect, and rare cases of idiosyncratic hepatitis were o...
Source: International Journal of Nephrology and Renovascular Disease - February 14, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

The clinicopathological features of patients with membranous nephropathy.
Conclusion: The major clinicopathological characteristics of MN patients are summarized in this study. Male and elder MN cases are likely to have rapid disease progression. Advanced pathological stages and being positive for anti-PLA2R antibodies may be potential indicators for disease activity of MN. PMID: 29403303 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - February 8, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Post-marketing surveillance study of the safety and efficacy of nalfurafine hydrochloride (Remitch ® capsules 2.5 μg) in 3,762 hemodialysis patients with intractable pruritus.
Post-marketing surveillance study of the safety and efficacy of nalfurafine hydrochloride (Remitch® capsules 2.5 μg) in 3,762 hemodialysis patients with intractable pruritus. Int J Nephrol Renovasc Dis. 2018;11:9-24 Authors: Kozono H, Yoshitani H, Nakano R Abstract Background: Intractable pruritus in hemodialysis patients can significantly decrease their quality of life and is also associated with poor vital prognosis. Although combined multiple causes of intractable pruritus in these patients have been identified, no existing treatments are proven to be sufficiently effective. We conducted a po...
Source: International Journal of Nephrology and Renovascular Disease - February 4, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Pulse versus daily oral Alfacalcidol treatment of secondary hyperparathyroidism in hemodialysis patients: a randomized controlled trial.
Conclusion: Switching daily alfacalcidol therapy to thrice-weekly alfacalcidol pulse therapy seems safe and convenient, especially for hemodialysis patients with poor compliance with treatment. This study also highlights the importance of monitoring and preventing malnutrition in hemodialysis patients and maintaining optimal glycemic control in diabetic hemodialysis patients. PMID: 29391823 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - February 4, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Calcium channel blockade and survival in recipients of successful renal transplant: an analysis of the FAVORIT trial results.
Conclusion: Although physiologic reasoning and small series results suggest a benefit for calcium channel blocking agents for allograft protection and sepsis prevention in immunosuppressed patients, we find no clear survival benefit in a large international renal transplant trial. PMID: 29317843 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - January 12, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Nutcracker syndrome associated with celiacomesentric trunk anomaly: case report.
Conclusion: Nutcracker syndrome associated with celiacomesenteric trunk anomaly is extremely uncommon and is a rare cause of hematuria in children. Whether this abnormal anatomy is the cause of nutcracker syndrome or just an association should be investigated. Moreover, awareness of this anatomical variation may help in planning therapeutic options and reducing the chance of surgical iatrogenic injuries. PMID: 29263687 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - December 23, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Urinary protein profiles in ketorolac-associated acute kidney injury in patients undergoing orthopedic day surgery.
CONCLUSION: AKI can ensue even in young adults who have undergone a short course of ketorolac, when they suffered from relative dehydration, abdominal disturbances, flank pain and oliguria after discharge. Urine findings were characterized by a marked nonselective glomerular proteinuria disappearing in 2-3 weeks. PMID: 29075132 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - October 29, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Efficacy and safety of subcutaneous administration of lyophilized powder of alfa-erythropoietin to maintain hemoglobin concentrations among hemodialysis patients.
CONCLUSION: In this study of anemia therapy among patients with end-stage renal disease on hemodialysis therapy, the SC injection of lyophilized powder EPO alfa was well tolerated and effectively maintained hemoglobin levels. Future studies of larger size and longer duration will be required to assess safety profiles. PMID: 29033600 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - October 17, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Role of serum cystatin-C and beta-2 microglobulin as early markers of renal dysfunction in children with beta thalassemia major.
CONCLUSION: Cystatin-C and β-2 microglobulin are specific and sensitive early biomarkers for monitoring glomerular and tubular dysfunction in children with β-TM. PMID: 28979155 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - October 7, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Renal sympathetic denervation increases renal blood volume per cardiac cycle: a serial magnetic resonance imaging study in resistant hypertension.
Authors: Delacroix S, Chokka RG, Nelson AJ, Wong DT, Sidharta S, Pederson SM, Rajwani A, Nimmo J, Teo KS, Worthley SG Abstract AIM: Preclinical studies have demonstrated improvements in renal blood flow after renal sympathetic denervation (RSDN); however, such effects are yet to be confirmed in patients with resistant hypertension. Herein, we assessed the effects of RSDN on renal artery blood flow and diameter at multiple time points post-RSDN. METHODS AND RESULTS: Patients (n=11) with systolic blood pressures ≥160 mmHg despite taking three or more antihypertensive medications at maximum tolerated dose were ...
Source: International Journal of Nephrology and Renovascular Disease - September 20, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Transforming growth factor- β1/Smad3-independent epithelial-mesenchymal transition in type I collagen glomerulopathy.
In this report, we investigate the role of transforming growth factor β1 (TGF-β1) in myofibroblast activation and epithelial-mesenchymal transition (EMT) in this glomerulopathy. Immunohistochemical analyses of glomerular α-sma, desmin, vimentin, and proliferating cell nuclear antigen demonstrated parietal epithelial cell proliferation and EMT in late stages of the glomerulopathy in the Col1a2-deficient mice. Glomerular TGF-β1 RNA and protein were not elevated in 1- and 3-month-old mice as determined by quantitative reverse transcriptase-polymerase chain reaction and protein immunoassay analyses. To inv...
Source: International Journal of Nephrology and Renovascular Disease - September 20, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

The role of novel biomarkers in predicting diabetic nephropathy: a review.
Authors: Uwaezuoke SN Abstract Diabetic nephropathy (DN) is one of the microvascular complications of the kidney arising commonly from type 1 diabetes mellitus (T1DM), and occasionally from type 2 diabetes mellitus (T2DM). Microalbuminuria serves as an early indicator of DN risk and a predictor of its progression as well as cardiovascular disease risk in both T1DM and T2DM. Although microalbuminuria remains the gold standard for early detection of DN, it is not a sufficiently accurate predictor of DN risk due to some limitations. Thus, there is a paradigm shift to novel biomarkers which would help to predict DN ris...
Source: International Journal of Nephrology and Renovascular Disease - September 3, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Does diabetes impact therapeutic immunomodulation therapy decisions for kidney transplant recipients? Data from the Folic Acid for Vascular Outcome Reduction in Transplant (FAVORIT) trial.
Authors: Weinrauch LA, D'Elia JA, Weir MR, Bunnapradist S, Finn P, Liu J, Claggett B, Monaco AP Abstract Although survival has improved for kidney transplant recipients over the past several decades, long-term survival in diabetic cohorts still is significantly less than that of non-diabetic cohorts. We hypothesized that among stable kidney transplant recipients, there might be differences between subgroups with and without diabetes with respect to prevalence of prior cardiovascular events and post-transplant antihypertensive and immunosuppressive therapy. We performed a post hoc analysis of participants in the Fol...
Source: International Journal of Nephrology and Renovascular Disease - September 3, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

The level of urinary semaphorin3A is associated with disease activity in patients with minimal change nephrotic syndrome.
We examined the serum and urinary semaphorin3A levels in 72 patients with renal disease and 5 healthy volunteers. The patients had been diagnosed with thin basement membrane disease (n=4), minimal change nephrotic syndrome (MCNS; n=22), IgA nephritis (n=21), membranous nephropathy (n=16) and focal segmental glomerular sclerosis (n=9). The level of urinary semaphorin3A in MCNS patients tended to be relatively high among all disease groups. We also investigated the urinary semaphorin3A level in 7 patients with MCNS from disease onset to remission during the drug therapy. MCNS patients in pre-remission states had higher urina...
Source: International Journal of Nephrology and Renovascular Disease - August 11, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Assessment of quality of life in patients undergoing hemodialysis using WHOQOL-BREF questionnaire: a multicenter study.
Authors: Joshi U, Subedi R, Poudel P, Ghimire PR, Panta S, Sigdel MR Abstract BACKGROUND: Assessment of quality of life (QOL) of patients with end-stage renal disease has become increasingly important, both in order to evaluate the influence of the disease on patients and the type of renal replacement therapy they require. Therefore, in this study, we aimed to assess QOL in patients undergoing hemodialysis and evaluated the effects of various sociodemographic factors affecting QOL of such patients in Nepal. METHODS: A cross-sectional study was conducted among 150 patients with chronic kidney disease undergoing ...
Source: International Journal of Nephrology and Renovascular Disease - August 11, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Hypertension in pediatric patients with chronic kidney disease: management challenges.
Authors: Gallibois CM, Jawa NA, Noone DG Abstract In contrast to adults where hypertension is a leading cause of chronic kidney disease, in pediatrics, hypertension is predominantly a sequela, however, an important one that, like in adults, is likely associated with a more rapid decline in kidney function or progression of chronic kidney disease to end stage. There is a significant issue with unrecognized, or masked, hypertension in childhood chronic kidney disease. Recent evidence and, therefore, guidelines now suggest targeting a blood pressure of
Source: International Journal of Nephrology and Renovascular Disease - August 11, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Stent tunnel technique to save thrombosed native hemodialysis fistula with extensive venous aneurysm.
CONCLUSION: The "stent tunnel technique" is a feasible, safe and effective alternative to salvage native hemodialysis access, thus extending the function of the venous access with no signs of stent-related complications and a respectable midterm patency. PMID: 28794652 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - August 11, 2017 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research