Factors Associated with Uremic Pruritus in Patients Undergoing Peritoneal Dialysis.
Conclusion: Uremic pruritus intensity was greater in the nighttime than in the daytime in PD patients. Male sex was associated with higher uremic pruritus intensity in the daytime, whereas PD vintage and topical medicine use were associated with higher uremic pruritus intensity in the nighttime. PMID: 32021382 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - February 7, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD): Current Perspectives.
Authors: Waziri B, Duarte R, Naicker S Abstract Despite the availability of global and regional guidelines to curtail the adverse clinical outcomes associated with chronic kidney disease-mineral and bone disorder (CKD-MBD), most CKD patients are still affected by the consequences of abnormalities of CKD-MBD. This important clinical complication of CKD continues to be studied, in order to improve the understanding and management of CKD-MBD. Some notable discoveries include the role of fibroblast growth factor 23 (FGF23) in the pathogenesis of CKD-MBD, leading to a shift from the previous well-established classic tra...
Source: International Journal of Nephrology and Renovascular Disease - January 12, 2020 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Clinical Significance Of Linc00342 Expression In The Peripheral Blood Lymphocytes Of Patients With Chronic Kidney Disease.
Authors: Liu C, Xu Y, Wu X, Zou Q Abstract Objective: To investigate the expression of Linc00342 in peripheral blood lymphocytes in patients with chronic kidney disease (CKD) and healthy people and to identify Linc00342 as a biomarker of chronic kidney disease. Methods: Peripheral blood samples were collected from 30 patients with chronic kidney disease and 10 healthy volunteers at the First Affiliated Hospital of Bengbu Medical College, China. According to CKD classification, the patients were divided into three CKD groups (the CKD1/2 group, CKD3/4 group and CKD5 group) and a healthy volunteer group (the H gro...
Source: International Journal of Nephrology and Renovascular Disease - December 20, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

The Importance of Tubular Function in Chronic Kidney Disease.
In conclusion, tubular function has an important role for endogenous organic cations, anions and drug excretion in CKD patients, and a deeper understanding of its multiple mechanisms could provide new therapeutic alternatives in this population. PMID: 31849512 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - December 20, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Frailty Screening in Chronic Kidney Disease: Current Perspectives.
Authors: Worthen G, Tennankore K Abstract Frailty has been defined as a state of increased vulnerability as a consequence of deficit accumulation. Frailty screening has not yet been widely implemented into routine nephrology care. Patients with chronic kidney disease (CKD) are at high risk of being frail, and frailty has been associated with worse outcomes in this population. Standard management of CKD, including initiation of renal replacement therapies, may have decreased benefit or potentially cause harm in the presence of frailty, and a variety of interventions for modifying frailty in the CKD population have b...
Source: International Journal of Nephrology and Renovascular Disease - December 13, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Effectiveness of Native Vitamin D Therapy in Patients with Chronic Kidney Disease Stage 3 and Hypovitaminosis D in Colombia, South America.
Conclusion: Cholecalciferol with adjustment in its dose, and obtaining normal serum levels is an excellent therapeutic alternative for the treatment of patients with CKD stage 3, and hypovitaminosis D. In the group of patients with GFR close to 30 mL/min, or lower values (stage 4), and with the presence of secondary hyperparathyroidism, the use of active form of vitamin D (calcitriol, paricalcitol) is recommended as the first therapeutic alternative. PMID: 31827333 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - December 13, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Prevalence Of Anemia And Its Associated Factors Among Chronic Kidney Disease Patients At University Of Gondar Hospital, Northwest Ethiopia: A Hospital-Based Cross Sectional Study.
This study aimed to determine the prevalence of anemia and its associated factors among CKD patients at the University of Gondar hospital, Northwest Ethiopia. Methods: A hospital-based cross-sectional study was conducted from May 1, to September 30, 2018. Consecutive sampling was used to recruit 251 study subjects. Patients were interviewed to obtain demographic data, and the patients' medical records were reviewed to obtain information on relevant medical history and laboratory parameters. Data was analyzed using SPSS version 20. Bivariate and multivariate logistic regression analyses were used to identify independent...
Source: International Journal of Nephrology and Renovascular Disease - November 7, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Medullary Sponge Kidney: Current Perspectives.
Authors: Imam TH, Patail H, Patail H Abstract Medullary Sponge Kidney (MSK) disease is a rare congenital malformation of the distal nephron where cystic dilatation is appreciable in the collecting ducts and renal papillae. Most cases of the malformation are thought to arise from a malfunction within neurotrophic factor and tyrosine kinase interactions. Presentation and prognosis are usually indolent; however, they include urinary tract infections (UTI), nephrolithiasis and nephrocalcinosis, distal renal tubular acidosis (dRTA) and hypocitraturia. With an insidious and asymptomatic onset, MSK is a difficult renal ma...
Source: International Journal of Nephrology and Renovascular Disease - October 4, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Chronic Kidney Disease And Associated Risk Factors Among Cardiovascular Patients.
In this study, CKD, defined as estimated GFR (eGFR)
Source: International Journal of Nephrology and Renovascular Disease - October 3, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Optimal management of atypical hemolytic uremic disease: challenges and solutions.
Authors: Raina R, Grewal MK, Radhakrishnan Y, Tatineni V, DeCoy M, Burke LL, Bagga A Abstract Atypical hemolytic uremic syndrome (aHUS) is a chronic life threatening condition that arises from genetic abnormalities resulting in uncontrolled complement amplifying activity. The introduction of eculizumab, the humanized monoclonal antibody, has brought about a paradigm shift in the management of aHUS. However, there are many knowledge gaps, diagnostic issues, access and cost issues, and patient or physician challenges associated with the use of this agent. Limited data on the natural history of aHUS along with the und...
Source: International Journal of Nephrology and Renovascular Disease - October 1, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

NSAID associated bilateral renal infarctions: a case report.
Authors: Jeon Y, Lis JB, Chang WG Abstract Renal infarctions (RIs) are caused by interruptions in the renal arterial blood flow. RIs are generally considered to be rare, however we present the case of a 37 year old woman whose renal infarction was likely due to the vasoconstrictive effects of non-steroidal anti-inflammatory drugs. Although high-dose non-steroidal anti-inflammatory drugs (NSAIDs) are known to cause a decrease in renal perfusion, they have not been accepted as causative agents in renal infarction. Theoretically, patients in prostaglandin dependent states should be more vulnerable to renovascular...
Source: International Journal of Nephrology and Renovascular Disease - August 28, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Prevalence rates of histopathologic subtypes associated with steroid resistance in childhood nephrotic syndrome in Sub-Saharan Africa: a systematic review.
Conclusion: The prevalence of FSGS is currently high in childhood nephrotic syndrome in SSA. This histopathologic subtype remains the commonest lesion associated with SRNS in this part of the globe. PMID: 31372025 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - August 4, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Report of health checkup system for chronic kidney disease in general population in Okayama city: effect of health guidance intervention on chronic kidney disease outcome.
In this study, we aimed to evaluate the effect of 2 years' CKD-follow-up project regarding renal function and CKD risks. Patients and methods: Those who received a health checkup by the national health insurance in Okayama city in 2011 were recruited. The patients with lifestyle-related diseases or metabolic syndrome were excluded. Subjects who had an estimated glomerular filtration rate
Source: International Journal of Nephrology and Renovascular Disease - July 18, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Acute kidney injury after cardiac surgery: prevalence, impact and management challenges.
Authors: Vives M, Hernandez A, Parramon F, Estanyol N, Pardina B, Muñoz A, Alvarez P, Hernandez C Abstract Acute kidney injury (AKI) is a major medical problem that is of particular concern after cardiac surgery. Perioperative AKI is independently associated with an increase in short-term morbidity, costs of treatment, and long-term mortality. In this review, we explore the definition of cardiac surgery-associated acute kidney injury (CSA-AKI) and identify diverse mechanisms and risk factors contributing to the renal insult. Current theories of the pathophysiology of CSA-AKI and description of its clinical c...
Source: International Journal of Nephrology and Renovascular Disease - July 16, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Evaluation of discriminative capacity of two formulas of CKD-EPI to predict complications after the first episode of heart failure with preserved ejection fraction.
Authors: Shchekochikhin D, Nikiforova T, Shilova A, Nesterov A, Baturina O, Gognieva D, Kozlovskaya N, Syrkin A, Kopylov P Abstract Background: Determining the prognosis of heart failure with preserved ejection fraction (HFpEF) is problematic, as the ejection fraction cannot be used. Formulae that estimate glomerular filtration rate (eGFR) may be potential prognosticators for this condition, since renal dysfunction is a well-known predictor of poor outcomes of all forms of heart failure. Methods: A prospective observational study of 117 HFpEF patients (average age 71.6±9.1 years; 65.8% women) who had eGFR de...
Source: International Journal of Nephrology and Renovascular Disease - June 15, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Prospects of genetic testing for steroid-resistant nephrotic syndrome in Nigerian children: a narrative review of challenges and opportunities.
This article describes the genetics of NS/SRNS in childhood and also gives a narrative review of the challenges and opportunities for molecular testing among children with SRNS in Nigeria. For these children to benefit from genetic diagnosis, Nigeria must aspire to have and develop the manpower and infrastructure required for medical genetics and genomic medicine, leveraging on her existing experiences in genomic medicine. Concerted efforts can be put in place to increase the number of enrollees in Nigeria's National Health Insurance Scheme (NHIS). The scope of the NHIS can be expanded to cater for the expensive bill of ge...
Source: International Journal of Nephrology and Renovascular Disease - June 15, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Tivozanib for the treatment of renal cell carcinoma: patient selection and perspectives.
Authors: Rodenburg RJ, Eskens F Abstract Tivozanib is an oral selective vascular endothelial growth factors receptor (VEGFR) tyrosine kinase inhibitor that is recently approved by the European Medicines Agency for the treatment of previously untreated patients with metastatic renal cell carcinoma (mRCC) as well as for those patients with disease progression during or after cytokine therapy. Nowadays, in first-line and second-line treatment of mRCC, there is an abundance of options, mainly consisting of VEGFR-directed tyrosinekinase inhibitors. This review focusses on the role of tivozanib with respect to patient se...
Source: International Journal of Nephrology and Renovascular Disease - June 15, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Butyrate production in patients with end-stage renal disease.
Conclusions: Patients with ESRD do not have a decreased amount of the most abundant butyrate-producing species nor a decreased butyrate-producing capacity. PMID: 31123416 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - May 29, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Dialysis disequilibrium syndrome prevention and management.
Authors: Mistry K Abstract The dialysis disequilibrium syndrome (DDS) is a clinical constellation of neurologic symptoms and signs occurring during or shortly following dialysis, especially when dialysis is first initiated. It is a diagnosis of exclusion occurring in those that are uremic and hyperosmolar, in whom rapid correction with renal replacement therapy leads to cerebral edema and raised intracranial pressure with resultant clinical neurologic manifestations. DDS is most commonly described in association with hemodialysis but can occur in patients with acute kidney injury requiring continuous renal replacem...
Source: International Journal of Nephrology and Renovascular Disease - May 25, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Hypertensive retinopathy and associated factors among nondiabetic chronic kidney disease patients seen at a tertiary hospital in Tanzania: a cross-sectional study.
Authors: Chillo P, Ismail A, Sanyiwa A, Ruggajo P, Kamuhabwa A Abstract Background: Hypertensive retinopathy is a known marker of cardiovascular disease, and among unselected patients with chronic kidney disease (CKD) more severe retinopathy has been associated with lower estimated glomerular filtration rate (eGFR). This association has, however, not been widely studied among nondiabetic hypertensive patients with CKD, especially in sub-Saharan Africa. We aimed to determine the prevalence and severity of hypertensive retinopathy and its relationship with eGFR among nondiabetic CKD patients seen at Muhimbili Nationa...
Source: International Journal of Nephrology and Renovascular Disease - May 25, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Patient engagement activities with health care professionals in continuous ambulatory peritoneal dialysis therapy: an exploratory pilot study.
Conclusion: Patients engagement activities played an important role in CAPD therapy. The engagement activities covered the cognitive, emotional, and behavioral dimensions. Obtaining initial knowledge as well as developing knowledge and skills are essential engagement activities before patients perform CAPD therapy. PMID: 31118739 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - May 25, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Nocturnal hemodialysis: improved quality of life and patient outcomes.
Authors: Koh TJK Abstract Conventional hemodialysis is associated with high morbidity and mortality rates, as well as a reduced quality of life. There is a growing interest in the provision of more intensive hemodialysis, due to associated benefits in terms of reduced cardiovascular morbidity, better regulation of mineral metabolism, as well as its impact on quality of life measures, fertility, and sleep. Nocturnal hemodialysis, both in center and at home, allows the delivery of more intensive hemodialysis. This review discusses the benefits of nocturnal hemodialysis and evaluates the evidence based on available li...
Source: International Journal of Nephrology and Renovascular Disease - May 3, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Prediction of cardiovascular outcomes with machine learning techniques: application to the Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL) study.
Conclusion: Prediction of a composite cardiovascular outcome was difficult in the CORAL population, even when employing machine learning methods. Assignment to either the stenting or best medical therapy group did not serve as an important predictor of composite outcome. Clinical Trial Registration: ClinicalTrials.gov, NCT00081731. PMID: 30962703 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - April 10, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Interactive and potentially independent roles of renin-angiotensin-aldosterone system blockade and the development of cardiorenal syndrome type 1 on in-hospital mortality among elderly patients admitted with acute decompensated congestive heart failure.
Conclusion: Our data suggest that development of CRS1 and lack of ACEI/A2RB usage are statistically independent predictors of in-hospital mortality for elderly ADCHF patients, with CRS1 being the stronger of the two risk factors. While it remains unclear whether lack of ACEI/ A2RB usage is causally related to increased mortality or reflects another risk factor inducing physicians to forego ACEIs/A2RBs, our findings nevertheless indicate the need to address this issue in future prospective studies. PMID: 30936736 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - April 3, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Ethnic prevalence of anemia and predictors of anemia among chronic kidney disease patients at a tertiary hospital in Johannesburg, South Africa.
Conclusion: Almost half of the CKD participants were anemic, and the odds of anemia did not increase linearly with increasing severity of CKD. There was a marked ethnic disparity in anemia prevalence. Our study highlights the need for risk-based management of anemia among CKD patients. PMID: 30858723 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - March 14, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Phosphate binder pill burden, adherence, and serum phosphorus control among hemodialysis patients converting to sucroferric oxyhydroxide.
We examined changes in phosphate binder pill burden, medication possession ratio (MPR), and phosphorus control among in-center hemodialysis (ICHD) patients converting to SO from another phosphate binder as part of routine care. Materials and methods: Patients included in this retrospective analysis (N=490) were ≥18 years old, received ICHD at a large dialysis organization (LDO), and were enrolled in the LDO's pharmacy service. Patients converting to SO were those who had supply of another phosphate binder, received a first prescription fill for SO, and subsequently did not refill the non-SO phosphate binder. Patient...
Source: International Journal of Nephrology and Renovascular Disease - February 20, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

HO-1 concentrations 24 hours after cardiac surgery are associated with the incidence of acute kidney injury: a prospective cohort study.
Conclusion: The association of the second HO-1 burst 24 hours after CBP might help to distinguish between the causality of AKI in patients undergoing CBP, thus helping to adapt patient stratification and management. PMID: 30774413 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - February 20, 2019 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

The potential diagnostic utility of coexpression of Ki-67 and P53 in the renal biopsy in pediatric lupus nephritis.
Authors: Rahbar MH, Rahbar MR, Mardanpour N, Mardanpour S Abstract Background: The proliferative activity as well as apoptosis has been suggested to play a role in the pathogenesis of lupus nephritis (LN). The aim of the study was to investigate the coexpression of Ki-67-triggered marked proliferation and P53-induced apoptosis in renal biopsy of childhood lupus nephritis (cLN) and to compare the coexpression of proliferative and apoptotic indices between different subgroups and clinicopathologic patterns of renal disease. Methods: Renal biopsy specimens of 33 children with lupus nephritis (LN) and 10 healthy su...
Source: International Journal of Nephrology and Renovascular Disease - December 29, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Self-management and associated factors among patients with end-stage renal disease undergoing hemodialysis at health facilities in Addis Ababa, Ethiopia.
Authors: Gela D, Mengistu D Abstract Introduction: Patients with end-stage renal disease (ESRD) face multifaceted problems arising from complications of the disease and dialysis that require consistent and, effective self-management from the patients' side, on top of the management offered by health care professionals. However, little is known about the level of self-management and influencing factors among patients with ESRD undergoing hemodialysis in the study area. Therefore, the aim of this study was to assess self-management and associated factors of patients with ESRD undergoing hemodialysis at health facilit...
Source: International Journal of Nephrology and Renovascular Disease - December 22, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Acute kidney injury among nonagenarians in Jordan: a retrospective case-control study.
Conclusion: AKI is common in nonagenarians. It was associated with increased length of hospital stays and increased risk for mortality. PMID: 30555251 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - December 19, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Evaluation of a protocol for coronary artery disease investigation in asymptomatic elderly hemodialysis patients.
Conclusion: In older patients on renal replacement therapy, the prevalence of CAD was high, but coronary investigation was not useful as a risk stratification tool and also resulted in a rather small proportion of patients eligible for intervention. Therefore, in the elderly, coronary investigation should not be considered routine in asymptomatic patients. PMID: 30532578 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - December 13, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Antineutrophil cytoplasmic antibody-associated vasculitis, update on molecular pathogenesis, diagnosis, and treatment.
Authors: Arman F, Barsoum M, Selamet U, Shakeri H, Wassef O, Mikhail M, Rastogi A, Hanna RM Abstract Circulating antineutrophil cytoplasmic antibodies (ANCAs) are the central pathogenic mechanism for a group of systemic and renal syndromes called the ANCA-associated vasculitis (AAV). The nomenclature has changed from eponymous labeling to granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis, and microscopic polyangiitis. These syndromes predominantly affect the pulmonary and renal systems. We also review the molecular pathology behind ANCAs and associated antigens and infections. Various ...
Source: International Journal of Nephrology and Renovascular Disease - December 13, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Successful salvage of allograft dysfunction triggered by transplant renal vein thrombosis immediately after kidney transplantation: a case report.
Conclusion: Although TRVT is induced by multiple factors, an accurate diagnosis is often difficult. Understanding these factors, including obesity, and considering TRVT as a cause of allograft dysfunction are important during the pre-, peri-, and postoperative periods. Knowledge of TRVT can lead to early and accurate diagnosis and intervention, resulting in better outcomes for the patients with allograft dysfunction. PMID: 30538528 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - December 13, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Bartter syndrome: causes, diagnosis, and treatment.
Authors: Cunha TDS, Heilberg IP Abstract Bartter syndrome is an inherited renal tubular disorder caused by a defective salt reabsorption in the thick ascending limb of loop of Henle, resulting in salt wasting, hypokalemia, and metabolic alkalosis. Mutations of several genes encoding the transporters and channels involved in salt reabsorption in the thick ascending limb cause different types of Bartter syndrome. A poor phenotype-genotype relationship due to the interaction with other cotransporters and different degrees of compensation through alternative pathways is currently reported. However, phenotypic identific...
Source: International Journal of Nephrology and Renovascular Disease - December 8, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Nocturnal blood pressure decrease in patients with chronic kidney disease and in healthy controls - significance of obstructive sleep apnea and renal function.
Authors: Hornstrup BG, Gjoerup PH, Wessels J, Lauridsen TG, Pedersen EB, Bech JN Abstract Background: Chronic kidney disease (CKD) is often associated with a blunted nocturnal BP decrease and OSA. However, it is not fully clear whether a relationship exists between reduction in renal function and obstructive sleep apnea (OSA) on the one hand and relative nocturnal BP decrease in CKD patients on the other. The aim of this study was to investigate the association between nocturnal BP decrease and renal function, the degree of OSA, vasoactive hormones, and renal sodium handling in CKD3-4 patients and healthy age-match...
Source: International Journal of Nephrology and Renovascular Disease - December 6, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Renal transplantation in patients with Alport syndrome: patient selection, outcomes, and donor evaluation.
Authors: Kashtan CE Abstract Alport syndrome is an inherited disorder of basement membrane collagen IV that frequently results in end-stage renal disease. Patients with Alport syndrome who undergo renal transplantation have generally excellent outcomes. Posttransplant antiglomerular basement membrane nephritis is a rare complication of renal transplantation for Alport syndrome. Because Alport syndrome is a genetic disorder, potential related donors must be carefully evaluated in order to minimize harm. PMID: 30410383 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - November 11, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Low aquaporin-2 excretion in the nephrotic syndrome: an escape from the vasopressin regulating effect.
Authors: Brovko M, Kozlovskaya L, Pulin A, Moiseev S, Sholomova V, Shchekochikhin D, Gognieva D, Milovanova L, Fomin V Abstract Purpose: Experimental studies suggest that the nephrotic syndrome is associated with "vasopressin escape", characterized by low aquaporin-2 (AQP2) expression in the collecting duct despite high vasopressin secretion. We investigated this phenomenon in patients with the nephrotic syndrome. Patients and methods: We recruited 47 patients with proteinuric kidney disease who were distributed into the following four groups: 1) nephrotic syndrome with kidney dysfunction (n=10); 2) n...
Source: International Journal of Nephrology and Renovascular Disease - November 11, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Serial changes in vessel walls of renal arteries after catheter-based renal artery denervation: insights from volumetric computed tomography analysis.
Conclusion: Change in vessel wall was greater within the segments receiving renal artery denervation. Baseline VWV predicted its substantial increase after the procedure. These observations suggest that atheroma burden within the renal arteries is a potential contributing factor to vascular changes after renal sympathetic denervation. PMID: 30310302 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - October 13, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Clinical value of a serum anti-PLA2R antibody in the diagnosis and monitoring of primary membranous nephropathy in adults.
Authors: Wu X, Liu L, Guo Y, Yang L Abstract Objective: To compare the positive rate of anti-PLA2R antibodies in patients with primary membranous nephropathy (PMN), secondary membranous nephropathy (SMN), and non-membrane nephropathy (non-MN); evaluate serum anti-PLA2R antibodies in the diagnosis of PMN; quantify the serum anti-PLA2R antibody levels during the treatment of PMN patients; and evaluate the clinical value of monitoring changes in serum anti-PLA2R antibody quantification levels. Methods: The kidney tissue was collected by kidney biopsy. The expression of PLA2R in glomeruli was detected by immunofluo...
Source: International Journal of Nephrology and Renovascular Disease - October 7, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Renal replacement therapy in patients with acute respiratory distress syndrome: a single-center retrospective study.
Conclusion: Timing of RRT initiation was not associated with a survival benefit. Prospective study in the utilization and outcomes of RRT in ARDS could assist in optimizing its usage in this population. PMID: 30288081 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - October 7, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Inflammatory milieu in contrast-induced nephropathy: a prospective single-center study.
Conclusion: Serum level of IL-33 was a significant predictor for development of CIN. Good clinical judgment and high serum levels of IL-33 may stratify patients into low and high risk for CIN. PMID: 30147351 [PubMed] (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - August 28, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Acute kidney injury in elderly patients: narrative review on incidence, risk factors, and mortality.
Authors: Yokota LG, Sampaio BM, Rocha EP, Balbi AL, Sousa Prado IR, Ponce D Abstract Acute kidney injury (AKI) is characterized by a sudden renal dysfunction with consequent increase of nitrogenous products, hydroelectrolytic and acid-base disorders. Its prevalence is high in hospitalized populations (4.9%-7.2%), especially in intensive care units (ICUs). Despite all the technical and therapeutic advances that have occurred in the last few decades, the overall mortality of AKI patients remains high, reaching 80% in ICU patients. Several conditions predispose a patient to progress with AKI, including age, sepsis, su...
Source: International Journal of Nephrology and Renovascular Disease - August 28, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Takayasu's disease effects on the kidneys: current perspectives.
Authors: Li Cavoli G, Mulè G, Vallone MG, Caputo F Abstract Takayasu arteritis (TA) is a chronic vasculitis disease of unknown etiology. Clinically significant renal disease is relatively common, and renovascular hypertension is the major renal problem. The assessment of TA activity is usually challenging because vascular inflammation may progress to fixed vascular injury without findings of active disease. Until now, the best therapeutic options have not been identified. This review highlights the current perspectives of renal involvement in TA. PMID: 30147353 [PubMed] (Source: International Journal of ...
Source: International Journal of Nephrology and Renovascular Disease - August 28, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Effects of tolvaptan on renal function in chronic kidney disease patients with volume overload.
Authors: Suzuki S, Hanafusa N, Kubota K, Tsuchiya K, Nitta K Abstract Background: Fluid overload in chronic kidney disease (CKD) is generally controlled by diuretics, with potentially harmful effects on renal function. The efficacy of tolvaptan, a vasopressin V2-receptor antagonist and aquaretic, has not been evaluated for fluid control in CKD with reduced renal function. Methods: Each patient from a group of 24 CKD patients on tolvaptan 15 mg/d plus conventional diuretics (T group) was matched by age and sex with a patient from a group of 24 CKD patients on conventional nonaquaretic diuretics alone not associa...
Source: International Journal of Nephrology and Renovascular Disease - August 28, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Relationship of inferior vena cava collapsibility to ultrafiltration volume achieved in critically ill hemodialysis patients.
Authors: Kaptein MJ, Kaptein JS, Oo Z, Kaptein EM Abstract Background: Ultrasound (US) assessment of intravascular volume may improve volume management of dialysis patients. We investigated the relationship of intravascular volume evaluated by inferior vena cava (IVC) US to net volume changes with intermittent hemodialysis (HD) in critically ill patients. Methods: A retrospective cohort of 113 intensive care unit patients in 244 encounters had clinical assessment of intravascular volume followed by US of respiratory/ventilatory variation of IVC diameter, and had HD within 24 h. IVC collapsibility index (IVC CI)...
Source: International Journal of Nephrology and Renovascular Disease - August 10, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Atherosclerotic vascular disease and its correlates in stable black South African kidney transplant recipients.
Authors: Oguntola SO, Hassan MO, Duarte R, Dix-Peek T, Dickens C, Olorunfemi G, Vachiat A, Paget G, Manga P, Naicker S Abstract Background: Despite remarkable improvement in renal function attributable to kidney transplantation, the burden of cardiovascular disease (CVD) among kidney transplant recipients (KTRs) remains high in the post-transplant period. Aggressive use of statins in KTRs may make lipoprotein ratios correlate better with atherosclerotic vascular disease (AsVD) when compared with traditional lipid profile parameters. We therefore evaluated the clinical and echocardiographic correlates of AsVD among ...
Source: International Journal of Nephrology and Renovascular Disease - July 25, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Peritoneal dialysis-related peritonitis: challenges and solutions.
Authors: Salzer WL Abstract Peritoneal dialysis is an effective treatment modality for patients with end-stage renal disease. The relative use of peritoneal dialysis versus hemodialysis varies widely by country. Data from a 2004 survey reports the percentage of patients with end-stage renal disease treated with peritoneal dialysis to be 5%-10% in economically developed regions like the US and Western Europe to as much as 75% in Mexico. This disparity is probably related to the availability and access to hemodialysis, or in some cases patient preference for peritoneal over hemodialysis. Peritoneal dialysis-related p...
Source: International Journal of Nephrology and Renovascular Disease - June 22, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Prevalence of chronic kidney disease in Nigeria: systematic review of population-based studies.
Conclusion: The prevalence of CKD was high but variable in Nigeria, influenced by the equation used to estimate the GFR. MDRD and CKD-EPI results are agreeable. There is a need for more population-based studies, with emphasis on repeating the GFR estimation after 3 months in subjects with GFR
Source: International Journal of Nephrology and Renovascular Disease - June 5, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Smoking and outcomes in kidney transplant recipients: a post hoc survival analysis of the FAVORIT trial.
Authors: Weinrauch LA, Claggett B, Liu J, Finn PV, Weir MR, Weiner DE, D'Elia JA Abstract Background: Tobacco use remains an international health problem with between 10% and 40% of adults currently using tobacco. Given the rising number of patients either awaiting or having received a kidney transplant and the absence of smoking cessation as the criterion for transplantation in guidelines, we explored the association between smoking status and clinical outcomes in kidney transplant recipients. Patients and methods: In this post hoc analysis of the Folic Acid for Vascular Outcome Reduction in Transplant trial, ...
Source: International Journal of Nephrology and Renovascular Disease - May 16, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research

Prediction of acute kidney injury in cirrhotic patients: a new score combining renal, liver and inflammatory markers.
Authors: Gameiro J, Agapito Fonseca J, Monteiro Dias J, Melo MJ, Jorge S, Velosa J, Lopes JA Abstract Introduction: Acute kidney injury (AKI) is common in hospitalized patients with cirrhosis and is associated with poor prognosis. A risk prediction score combining values easily measured at admission could be valuable to stratify patients for prevention, monitoring and early intervention, ultimately improving patient care and outcomes. The aim of this study was to develop a risk score for AKI in a cohort of cirrhotic patients. Patients and methods: We cross-examined the data from a retrospective analysis of 186 ...
Source: International Journal of Nephrology and Renovascular Disease - May 9, 2018 Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research