Xanthogranulomatous Pyelonephritis: A Narrative Review with Current Perspectives on Diagnostic Imaging and Management, Including Interventional Radiology Techniques
Int J Nephrol Renovasc Dis. 2021 Sep 7;14:359-369. doi: 10.2147/IJNRD.S236552. eCollection 2021.ABSTRACTXanthogranulomatous Pyelonephritis (XGP) is a rare, chronic granulomatous inflammatory condition thought to arise secondary to a combination of obstruction, recurrent bacterial infection and an incomplete immune response resulting in focal or diffuse renal destruction. This destruction may be profound with the potential to infiltrate surrounding tissues and viscera. The imaging features of XGP can be ambiguous, mimicking malignancy, tuberculosis (TB) and malakoplakia earning the title of "the great imitator". C...
Source: International Journal of Nephrology and Renovascular Disease - September 15, 2021 Category: Urology & Nephrology Authors: Mark Paul Bolger Jennifer Hennebry Caoimhe Byrne Laura Greene Andreea Stroiescu Joan Heneghan Anthony Gerard Ryan Source Type: research

Integrating Monitoring of Volume Status and Blood Volume-Controlled Ultrafiltration into Extracorporeal Kidney Replacement Therapy
CONCLUSION: This study demonstrates that a clinical approach to kidney replacement therapy that tracks volume status and manages intradialytic fluid removal by blood volume-controlled UF delivers adequate dialysis without compromising fluid removal. It maintains volume status and ensures low incidence of IMEs.PMID:34511978 | PMC:PMC8416185 | DOI:10.2147/IJNRD.S319911 (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - September 13, 2021 Category: Urology & Nephrology Authors: Sebastian Zsch ätzsch Manuela Stauss-Grabo Adelheid Gauly Jennifer Braun Source Type: research

Accelerated Atherosclerosis in Systemic Lupus Erythematosus: Role of Fibroblast Growth Factor 23- Phosphate Axis
CONCLUSION: FGF23-phosphate axis has a key role in accelerated ACVD in SLE patients. Serum phosphorus and iFGF23 should be included in ACVD risk profile assessment of these patients. Prospective studies shall define the role of dietary and/or pharmacologic control of hyperphosphatemia and proteinuria in reducing circulating iFGF23 and ACVD in them.PMID:34475774 | PMC:PMC8407679 | DOI:10.2147/IJNRD.S326399 (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - September 3, 2021 Category: Urology & Nephrology Authors: Yaser Ammar Amira Mohamed Gihane Khalil Dalia Maharem Source Type: research

Acute Kidney Injury and Extracorporeal Membrane Oxygenation: Review on Multiple Organ Support Options
Int J Nephrol Renovasc Dis. 2021 Aug 13;14:321-329. doi: 10.2147/IJNRD.S292893. eCollection 2021.ABSTRACTExtracorporeal membrane oxygenation (ECMO) is a temporary life support system used to assist patients with life-threatening severe cardiac and/or respiratory insufficiency. Patients requiring ECMO can be considered the sickest patients admitted to the intensive care unit (ICU). Acute kidney injury (AKI) represents a frequent complication during ECMO, affecting up to 70% of patients, with multifactorial pathophysiology and an independent risk factor for mortality. Severe AKI requiring Continuous Renal Replacement Therapy...
Source: International Journal of Nephrology and Renovascular Disease - August 20, 2021 Category: Urology & Nephrology Authors: Lorenzo Foti Gianluca Villa Stefano Romagnoli Zaccaria Ricci Source Type: research

Multidisciplinary Perspectives of Current Approaches and Clinical Gaps in the Management of Hyperphosphatemia
Int J Nephrol Renovasc Dis. 2021 Aug 6;14:301-311. doi: 10.2147/IJNRD.S318593. eCollection 2021.ABSTRACTPopulation-based studies have shown that most patients with advanced chronic kidney disease (CKD) do not have optimal phosphate levels. Meta-analyses suggest that there is a morbidity and mortality benefit associated with the lowering of serum phosphate levels. However, to date there is no conclusive evidence from randomized controlled trials (RCTs) that lowering serum phosphate levels reduces the risk of morbidity and mortality. However, hyperphosphatemia may pose a risk to patients and treatment should be considered. W...
Source: International Journal of Nephrology and Renovascular Disease - August 16, 2021 Category: Urology & Nephrology Authors: Michel Vall ée Jordan Weinstein Marisa Battistella Roxanne Papineau Dianne Moseley Gordon Wong Source Type: research

Efficacy of Lactulose versus Senna Plus Ispaghula Husk Among Patients with Pre-Dialysis Chronic Kidney Disease and Constipation: A Randomized Controlled Trial
Int J Nephrol Renovasc Dis. 2021 Aug 7;14:313-319. doi: 10.2147/IJNRD.S328208. eCollection 2021.ABSTRACTBACKGROUND: Constipation is a common problem among patients with advanced chronic kidney disease (CKD), leading to a loss of quality of life. Pharmacologic treatments are in common use, but whether lactulose and senna plus ispaghula husk is effecive to treat constipation among patients with pre-dialysis CKD remains unknown.OBJECTIVE: The aim of the study was to compare efficacy of lactulose and senna plus ispaghula husk to treat constipation among patients with pre-dialysis CKD.METHODS: A study was conducted among patien...
Source: International Journal of Nephrology and Renovascular Disease - August 16, 2021 Category: Urology & Nephrology Authors: Naowanit Nata Supaporn Suebsiripong Bancha Satirapoj Ouppatham Supasyndh Amnart Chaiprasert Source Type: research

Multidisciplinary Perspectives of Current Approaches and Clinical Gaps in the Management of Hyperphosphatemia
Int J Nephrol Renovasc Dis. 2021 Aug 6;14:301-311. doi: 10.2147/IJNRD.S318593. eCollection 2021.ABSTRACTPopulation-based studies have shown that most patients with advanced chronic kidney disease (CKD) do not have optimal phosphate levels. Meta-analyses suggest that there is a morbidity and mortality benefit associated with the lowering of serum phosphate levels. However, to date there is no conclusive evidence from randomized controlled trials (RCTs) that lowering serum phosphate levels reduces the risk of morbidity and mortality. However, hyperphosphatemia may pose a risk to patients and treatment should be considered. W...
Source: International Journal of Nephrology and Renovascular Disease - August 16, 2021 Category: Urology & Nephrology Authors: Michel Vall ée Jordan Weinstein Marisa Battistella Roxanne Papineau Dianne Moseley Gordon Wong Source Type: research

Efficacy of Lactulose versus Senna Plus Ispaghula Husk Among Patients with Pre-Dialysis Chronic Kidney Disease and Constipation: A Randomized Controlled Trial
Int J Nephrol Renovasc Dis. 2021 Aug 7;14:313-319. doi: 10.2147/IJNRD.S328208. eCollection 2021.ABSTRACTBACKGROUND: Constipation is a common problem among patients with advanced chronic kidney disease (CKD), leading to a loss of quality of life. Pharmacologic treatments are in common use, but whether lactulose and senna plus ispaghula husk is effecive to treat constipation among patients with pre-dialysis CKD remains unknown.OBJECTIVE: The aim of the study was to compare efficacy of lactulose and senna plus ispaghula husk to treat constipation among patients with pre-dialysis CKD.METHODS: A study was conducted among patien...
Source: International Journal of Nephrology and Renovascular Disease - August 16, 2021 Category: Urology & Nephrology Authors: Naowanit Nata Supaporn Suebsiripong Bancha Satirapoj Ouppatham Supasyndh Amnart Chaiprasert Source Type: research

Multidisciplinary Perspectives of Current Approaches and Clinical Gaps in the Management of Hyperphosphatemia
Int J Nephrol Renovasc Dis. 2021 Aug 6;14:301-311. doi: 10.2147/IJNRD.S318593. eCollection 2021.ABSTRACTPopulation-based studies have shown that most patients with advanced chronic kidney disease (CKD) do not have optimal phosphate levels. Meta-analyses suggest that there is a morbidity and mortality benefit associated with the lowering of serum phosphate levels. However, to date there is no conclusive evidence from randomized controlled trials (RCTs) that lowering serum phosphate levels reduces the risk of morbidity and mortality. However, hyperphosphatemia may pose a risk to patients and treatment should be considered. W...
Source: International Journal of Nephrology and Renovascular Disease - August 16, 2021 Category: Urology & Nephrology Authors: Michel Vall ée Jordan Weinstein Marisa Battistella Roxanne Papineau Dianne Moseley Gordon Wong Source Type: research

Efficacy of Lactulose versus Senna Plus Ispaghula Husk Among Patients with Pre-Dialysis Chronic Kidney Disease and Constipation: A Randomized Controlled Trial
Int J Nephrol Renovasc Dis. 2021 Aug 7;14:313-319. doi: 10.2147/IJNRD.S328208. eCollection 2021.ABSTRACTBACKGROUND: Constipation is a common problem among patients with advanced chronic kidney disease (CKD), leading to a loss of quality of life. Pharmacologic treatments are in common use, but whether lactulose and senna plus ispaghula husk is effecive to treat constipation among patients with pre-dialysis CKD remains unknown.OBJECTIVE: The aim of the study was to compare efficacy of lactulose and senna plus ispaghula husk to treat constipation among patients with pre-dialysis CKD.METHODS: A study was conducted among patien...
Source: International Journal of Nephrology and Renovascular Disease - August 16, 2021 Category: Urology & Nephrology Authors: Naowanit Nata Supaporn Suebsiripong Bancha Satirapoj Ouppatham Supasyndh Amnart Chaiprasert Source Type: research

Musculoskeletal Disorders and Associated Factors Among Patients with Chronic Kidney Disease Attending at Saint Paul Hospital, Addis Ababa, Ethiopia
Int J Nephrol Renovasc Dis. 2021 Aug 4;14:291-300. doi: 10.2147/IJNRD.S319991. eCollection 2021.ABSTRACTBACKGROUND: Musculoskeletal disorders contributed from chronic kidney disease are increasing worldwide. Musculoskeletal disorders had a significant health burden and are leading causes of co-morbidities, disability and low productivity, which potentially affect individual's functional status and quality of life.PURPOSE: The aim of this study was to assess the prevalence of musculoskeletal disorders and its associated factors among patients with chronic kidney attending in Saint Paul Hospital, Addis Ababa, Ethiopia.PATIEN...
Source: International Journal of Nephrology and Renovascular Disease - August 11, 2021 Category: Urology & Nephrology Authors: Sisay Deme Berihu Fisseha Gebreslassie Kahsay Haimanot Melese Abayneh Alamer Sileshi Ayhualem Source Type: research

Renal Involvement in Retroperitoneal Fibrosis: Prevalence, Impact and Management Challenges
Int J Nephrol Renovasc Dis. 2021 Jul 29;14:279-289. doi: 10.2147/IJNRD.S239160. eCollection 2021.ABSTRACTRetroperitoneal fibrosis (RPF) is a rare disorder consisting of idiopathic and various secondary forms and characterized by chronic inflammatory infiltrates and marked fibrosis in the retroperitoneal space. In idiopathic RPF (IRPF), 35-60% of cases have been reported to be IgG4-related RPF, the retroperitoneal lesions of IgG4-related disease (IgG4-RD). IRPF can frequently lead to renal insufficiency mediated by urinary tract obstruction and hydronephrosis irrespective of being IgG4-related or not. Clinical pictures, lab...
Source: International Journal of Nephrology and Renovascular Disease - August 5, 2021 Category: Urology & Nephrology Authors: Ichiro Mizushima Mitsuhiro Kawano Source Type: research

Noninfectious, Severe Cryoglobulinemic Vasculitis with Renal Involvement - Safety and Efficacy of Long-Term Treatment with Rituximab
CONCLUSION: Data from our observation show the efficacy of rituximab in the refractory, nonviral cryoglobulinemic vasculitis with a severe course of the disease. However, the therapy is associated with the risk of SAEs, especially in elderly patients with kidney failure and significant immunologic alterations.PMID:34295176 | PMC:PMC8291846 | DOI:10.2147/IJNRD.S315388 (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - July 23, 2021 Category: Urology & Nephrology Authors: Ksymena Le śniak Aleksandra Rymarz Arkadiusz Lubas Stanis ław Niemczyk Source Type: research

Low-Intensity Shockwave Therapy (LI-ESWT) in Diabetic Kidney Disease: Results from an Open-Label Interventional Clinical Trial
CONCLUSION: LI-ESWT treatment did not significantly improve kidney function and albumin excretion. It is concluded that LI-ESWT is not harmful. A randomized blinded study should be performed to clarify whether adjunctive treatment with LI-ESWT is superior to standard treatment of DKD.PMID:34285548 | PMC:PMC8286109 | DOI:10.2147/IJNRD.S315143 (Source: International Journal of Nephrology and Renovascular Disease)
Source: International Journal of Nephrology and Renovascular Disease - July 21, 2021 Category: Urology & Nephrology Authors: Sune Moeller Skov-Jeppesen Knud Bonnet Yderstraede Boye L Jensen Claus Bistrup Milad Hanna Lars Lund Source Type: research

Role of Urinary Beta 2 Microglobulin and Kidney Injury Molecule-1 in Predicting Kidney Function at One Year Following Acute Kidney Injury
Int J Nephrol Renovasc Dis. 2021 Jul 5;14:225-234. doi: 10.2147/IJNRD.S319933. eCollection 2021.ABSTRACTBACKGROUND: There is only limited information on the utility of urinary biomarkers in predicting long-term kidney function following acute kidney injury (AKI). The current study assessed whether urinary beta 2 microglobulin/creatinine (B2M/creat) and kidney injury molecule-1/creatinine (KIM-1/creat) ratios, measured in the early recovery phase of AKI, are predictive of kidney function at one year.METHODS: This is a prospective study done in a tertiary care centre in South India, from March 2017 to December 2018. Adult pa...
Source: International Journal of Nephrology and Renovascular Disease - July 16, 2021 Category: Urology & Nephrology Authors: Dhanin Puthiyottil P S Priyamvada Mattewada Naveen Kumar Anand Chellappan Bobby Zachariah Sreejith Parameswaran Source Type: research

Malaria-Associated Acute Kidney Injury in African Children: Prevalence, Pathophysiology, Impact, and Management Challenges
Int J Nephrol Renovasc Dis. 2021 Jul 8;14:235-253. doi: 10.2147/IJNRD.S239157. eCollection 2021.ABSTRACTAcute kidney injury (AKI) is emerging as a complication of increasing clinical importance associated with substantial morbidity and mortality in African children with severe malaria. Using the Kidney Disease: Improving Global Outcomes (KDIGO) criteria to define AKI, an estimated 24-59% of African children with severe malaria have AKI with most AKI community-acquired. AKI is a risk factor for mortality in pediatric severe malaria with a stepwise increase in mortality across AKI stages. AKI is also a risk factor for post-d...
Source: International Journal of Nephrology and Renovascular Disease - July 16, 2021 Category: Urology & Nephrology Authors: Anthony Batte Zachary Berrens Kristin Murphy Ivan Mufumba Maithri L Sarangam Michael T Hawkes Andrea L Conroy Source Type: research

Role of Urinary Beta 2 Microglobulin and Kidney Injury Molecule-1 in Predicting Kidney Function at One Year Following Acute Kidney Injury
Int J Nephrol Renovasc Dis. 2021 Jul 5;14:225-234. doi: 10.2147/IJNRD.S319933. eCollection 2021.ABSTRACTBACKGROUND: There is only limited information on the utility of urinary biomarkers in predicting long-term kidney function following acute kidney injury (AKI). The current study assessed whether urinary beta 2 microglobulin/creatinine (B2M/creat) and kidney injury molecule-1/creatinine (KIM-1/creat) ratios, measured in the early recovery phase of AKI, are predictive of kidney function at one year.METHODS: This is a prospective study done in a tertiary care centre in South India, from March 2017 to December 2018. Adult pa...
Source: International Journal of Nephrology and Renovascular Disease - July 16, 2021 Category: Urology & Nephrology Authors: Dhanin Puthiyottil P S Priyamvada Mattewada Naveen Kumar Anand Chellappan Bobby Zachariah Sreejith Parameswaran Source Type: research

Malaria-Associated Acute Kidney Injury in African Children: Prevalence, Pathophysiology, Impact, and Management Challenges
Int J Nephrol Renovasc Dis. 2021 Jul 8;14:235-253. doi: 10.2147/IJNRD.S239157. eCollection 2021.ABSTRACTAcute kidney injury (AKI) is emerging as a complication of increasing clinical importance associated with substantial morbidity and mortality in African children with severe malaria. Using the Kidney Disease: Improving Global Outcomes (KDIGO) criteria to define AKI, an estimated 24-59% of African children with severe malaria have AKI with most AKI community-acquired. AKI is a risk factor for mortality in pediatric severe malaria with a stepwise increase in mortality across AKI stages. AKI is also a risk factor for post-d...
Source: International Journal of Nephrology and Renovascular Disease - July 16, 2021 Category: Urology & Nephrology Authors: Anthony Batte Zachary Berrens Kristin Murphy Ivan Mufumba Maithri L Sarangam Michael T Hawkes Andrea L Conroy Source Type: research