Delivery of mesenchymal stem cells for tackling systemic disorders.
The objective of this article is to fill this gap by reviewing the current status of research on systemic stem cell delivery, and by presenting the opportunities and challenges for translating systemic stem cell delivery from the laboratory to the clinic. PMID: 33461472 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - January 18, 2021 Category: Stem Cells Authors: Lai WF Tags: Curr Stem Cell Res Ther Source Type: research

Nanomaterials and Cell Biology.
PMID: 33443003 [PubMed - in process] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - January 16, 2021 Category: Stem Cells Authors: Lin Y, Zhou R Tags: Curr Stem Cell Res Ther Source Type: research

Regenerative Medicine Approaches in COVID -19 Pneumonia.
Abstract Regenerative medicine (RM) is an interdisciplinary field that uses different approaches to accelerate the repair and regeneration or replace damaged or diseased human cells or tissues to achieve normal tissue function. These approaches include the stimulation of the body's own repair processes, transplantation of progenitor cells, stem cells, or tissues, as well as the use of cells and exosomes as delivery-vehicles for cytokines, genes, or other therapeutic agents. COVID-19 pneumonia is a specific disease consistent with diffuse alveolar damage resulting in severe hypoxemia. Therefore, the most serious ca...
Source: Current Stem Cell Research and Therapy - January 12, 2021 Category: Stem Cells Authors: Asgharzad S, Alizadeh A, Arab S Tags: Curr Stem Cell Res Ther Source Type: research

Interpreting the mechanisms by which integrins promote the differentiation of mesenchymal stem cells and integrin application prospects.
Abstract Transmembrane integrin receptors represent a major composition of cell- extracellular matrix (ECM) communications that mediate cellular biological activities including proliferation and differentiation. Stem cells, especially mesenchymal stem cells (MSC) have rapidly emerged as promising therapies for various diseases. Dynamic links exist between extracellular and intracellular environments that profoundly influence the cellular activities via integrin receptors, such as cell morphology transformation and differentiation. Interpreting the roles of integrin receptors in the regulation of MSC differentiatio...
Source: Current Stem Cell Research and Therapy - January 6, 2021 Category: Stem Cells Authors: Ying L, Wang C, Shi K, Zhou X, Gong Z, Shu J, Wang J, Xia K, Xiao S, Yu C, Yu W, Huang X, Cheng F, Liang C, Li F, Chen Q Tags: Curr Stem Cell Res Ther Source Type: research

Regenerative potential of stem cells derived from human exfoliated deciduous (SHED) teeth during engineering of human body tissues.
Abstract Current decade witnesses the regenerative potential of stem cells (SCs) based life-saving therapies for the treatment of various disease and conditions. Human teeth act as reservoir for SCs that exist with high abundance in baby, wisdom, and permanent teeth. The collection of stem cells from human exfoliated deciduous teeth (SHED) is considered as a simple process as it offers the convenience of little or no pain. In comparison to the SCs from dental or bone marrow or other tissues, the SHED offers the benefit of higher cellular differentiation and proliferation. Massive in vitro and in vivo studies revea...
Source: Current Stem Cell Research and Therapy - December 31, 2020 Category: Stem Cells Authors: Fuloria S, Jain A, Singh S, Hazarika I, Salile S, Fuloria NK Tags: Curr Stem Cell Res Ther Source Type: research

Stem Cells Derived from Human Exfoliated Deciduous teeth [shed] in Neuronal Disorders: A Review.
Abstract Most conventional treatments for neurodegenerative diseases fail due to their focus on neuroprotection rather than neurorestoration. Stem cell-based therapies are becoming a potential treatment option for neurodegenerative diseases as they can home in, engraft, differentiate and produce factors for CNS recovery. Stem cells derived from human dental pulp tissue differ from other sources of mesenchymal stem cells due to their embryonic neural crest origin and neurotrophic property. These include both dental pulp stem cells [DPSCs] from dental pulp tissues of human permanent teeth and stem cells from human e...
Source: Current Stem Cell Research and Therapy - December 21, 2020 Category: Stem Cells Authors: Anoop M, Datta I Tags: Curr Stem Cell Res Ther Source Type: research

Application of Stem Cells from Human Exfoliated Dental Pulp Stem Cells for Tissue Engineering and Tissue Regeneration.
PMID: 33349221 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - December 21, 2020 Category: Stem Cells Authors: Haque N, Abu Kasim NH Tags: Curr Stem Cell Res Ther Source Type: research

Concise Review; Effects of Antibiotics and Antimycotics on the Biological Properties of Human Pluripotent and Multipotent Stem Cells.
Abstract Human pluripotent stem cells (PSCs) including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) have the remarkable potential to self-renew and develop into various cell lineages. Human mesenchymal stem cells (MSCs) or multipotent stem cells that are present in various organs can self-renew and differentiate into multiple mesenchymal lineages. Both human PSCs and MSCs hold great promise in cell-based therapies, disease modeling, drug discovery, and regenerative medicine. Human stem cells must be cultured under the optimal conditions to use them in transplantology. Therefore, researche...
Source: Current Stem Cell Research and Therapy - December 3, 2020 Category: Stem Cells Authors: Farzaneh M Tags: Curr Stem Cell Res Ther Source Type: research

Various Cell Therapy Approaches for Bone Diseases in the Controlled Clinical Trials: A Systematic Review and Meta-analysis study.
The objective of this review was to answer two critical questions in the cell-based bone defect therapies that were as follows: 1) does cell therapy associate with the increase in the occurrence of adverse events in the patients compared to control groups, 2) does the use of various cell therapy approaches, including more-than minimal manipulation (MMM) and minimal manipulation (MM), affect the occurrence of adverse events?. An electronic literature search was performed in five databases. The controlled clinical trial studies were selected according to the eligibility criteria. Then, they were categorized into MMM and MM a...
Source: Current Stem Cell Research and Therapy - November 30, 2020 Category: Stem Cells Authors: Bouhlouli M, Izadi N, Khojasteh A Tags: Curr Stem Cell Res Ther Source Type: research

Mesenchymal stem Cells as a Treatment Strategy for Coronavirus Disease 2019 (COVID-19): Need for Authority Regulations and Clinical Guidelines.
Abstract The cause of coronavirus disease 2019 (COVID-19) known as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, formerly designated 2019-nCoV) was first discovered in December 2019 in Wuhan, China. It then spread rapidly worldwide. Investigation for discovery of drugs to cure this disease continues. The currently accepted treatments are supportive but there is no specific disease curing intervention found yet. Since mid-February, therapies involving mesenchymal stem/stromal cells (MSCs) have been proposed for the treatment of patients with COVID-19. In light of these recent developments this re...
Source: Current Stem Cell Research and Therapy - November 24, 2020 Category: Stem Cells Authors: Tufan AC Tags: Curr Stem Cell Res Ther Source Type: research

Applications of Umbilical Cord Derived Mesenchymal Stem Cells in Autoimmune and Immunological Disorders: From Literature to Clinical Practice.
Abstract Mesenchymal stem cells (MSCs) enable a novel approach in stem cell therapy. Bone marrow (BM) was the first source used in MSCs therapy. However, BM has a number of key limitations as a source of MSCs, such as existence of only a small number of MSCs in the tissue, the painful, ethically problematic, and invasive nature of the associated collection process, and decrease in MSC specifications as age of donors increases. As a result, there has been increasing scholarly attention in identifying alternative sources for MSCs. In specific, Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) has been identified as a ...
Source: Current Stem Cell Research and Therapy - November 24, 2020 Category: Stem Cells Authors: Abbaspanah B, Reyhani S, Mousavi SH Tags: Curr Stem Cell Res Ther Source Type: research

Hepatocyte Growth Factor and Insulin-like Growth Factor-1 based Cellular Therapies for Oxidative Stress Injury.
Abstract Imbalance between free radicals and antioxidants causes oxidative stress by the accumulation of reactive oxygen species (ROS) in the tissues and organs. Oxidative stress occurs in many damage conditions, and the increase of ROS and reduction of antioxidants enhances inflammation, apoptosis, fibrosis and may worsen the pathology leading to organ failure. The potential therapies aim to increase antioxidants and decrease ROS. Mesenchymal stem cells (MSCs) isolated from the stroma of various tissues are multipotent cells and have beneficial effects on several diseases with their immunomodulation and regenerat...
Source: Current Stem Cell Research and Therapy - November 24, 2020 Category: Stem Cells Authors: Sahan OB, Gunel-Ozcan A Tags: Curr Stem Cell Res Ther Source Type: research

Open Challenges and New Perspectives in Cardiac Regenerative Medicine.
PMID: 33213311 [PubMed - in process] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - November 21, 2020 Category: Stem Cells Authors: Pagano F, Chimenti I Tags: Curr Stem Cell Res Ther Source Type: research

From Endodontic Therapy to Regenerative Endodontics: New Wine in Old Bottles.
Abstract The concept of regenerative endodontics wherein one can replace damaged pulp structures and recuperate the functionality in erstwhile necrotic and infected root canal systems has been a cutting-edge technology. Though the notion started as early as the 1960s even before the discovery of stem cells and regenerative medicine, it was in the 2000s, this procedure gained momentum. Ever since then, researchers continue to discover its essential benefit to immature teeth and its ability to overcome the caveats of endodontic therapy which is commonly known as root canal treatment. Further, through this therapy, o...
Source: Current Stem Cell Research and Therapy - November 16, 2020 Category: Stem Cells Authors: Lim GS, Wey MC, Azami NH, Mohd Noor NS, Lau MN, Haque N, Govindasamy V, Abu Kasim NH Tags: Curr Stem Cell Res Ther Source Type: research

Potential of combination of bone marrow nucleated and mesenchymal stem cells in complete spinal cord injury.
CONCLUSION: A combination of these two cell types, BMMNC and MSC has been proven to be advantageous than applying them separately. Therefore, a thorough evaluation including rationale and potential implications of applying these two therapies has been presented here and we hypothesize that such a combination is likely to improvise the outcome of a wholesome approach to spinal cord regeneration after SCI. PMID: 33121414 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - October 29, 2020 Category: Stem Cells Authors: Katoh S, Dedeepiya VD, Kuroda S, Iwasaki M, Senthilkumar R, Preethy S, Abraham SJ Tags: Curr Stem Cell Res Ther Source Type: research

The Role of Cytokines in Interactions of Mesenchymal Stem Cells and Breast Cancer Cells.
Abstract Mesenchymal stem cells because of its high proliferation, differentiation, regenerative capacity, and ease of availability have been a popular choice in cytotherapy. Mesenchymal Stem Cells (MSCs) have a natural tendency to home in a tumor microenvironment and acts against it, owing to the similarity of the latter to an injured tissue environment. Several studies have confirmed the recruitment of MSCs by tumor through various cytokine signaling that brings about phenotypic changes to cancer cells, thereby promoting migration, invasion, and adhesion of cancer cells. The contrasting results on MSCs as a tool...
Source: Current Stem Cell Research and Therapy - October 22, 2020 Category: Stem Cells Authors: Jayaraman H, Ghone NV, Kumaran R R, Dashora H Tags: Curr Stem Cell Res Ther Source Type: research

Current Study and Novel Understanding for Macrophages.
PMID: 33070768 [PubMed - in process] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - October 21, 2020 Category: Stem Cells Authors: Kong L Tags: Curr Stem Cell Res Ther Source Type: research

Corrigendum: Stem Cells in Rotator Cuff Injuries and Reconstructions: A Systematic Review and Meta-Analysis.
Abstract Current Stem Cell Research & Therapy, 2019, 14(8): 683-697 Heyong Yin's affiliation should be: Department of Orthopaedics, Beijing Friendship Hospital, Capital Medical University, Beijing China; Zexing Yan's affiliation should be: Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong University, No.324, Road Jing Wu Wei Qi, Jinan 250021, Shandong, China. The Original Paragraph Provided is Mentioned Below: Fanxiao Liu1, Qingqi Meng2, Heyong Yin3,* and Zexing Yan3,* 1Department of Orthopaedics, Shandong Provincial Hospital Affiliated to Shandong University, No.324, Road Jing Wu...
Source: Current Stem Cell Research and Therapy - October 21, 2020 Category: Stem Cells Authors: Liu F, Meng Q, Yin H, Yan Z Tags: Curr Stem Cell Res Ther Source Type: research

Applications of Poly (caprolactone)-Based Nanofibre Electrospun Scaffolds in Tissue Engineering and Regenerative Medicine.
Abstract Diseases, trauma, and injuries are highly prevalent conditions that lead to many critical tissue defects. Tissue engineering has great potentials to develop functional scaffolds that mimic natural tissue structures to improve or replace biological functions. In many kinds of technologies, electrospinning has received widespread attention for its outstanding functions, which is capable of producing nanofibre structures similar to the natural extracellular matrix. Amongst, the electrospinning of available biopolymers, poly (caprolactone) (PCL), has shown favorable outcomes for tissue regeneration applicatio...
Source: Current Stem Cell Research and Therapy - October 14, 2020 Category: Stem Cells Authors: Zhang W, Weng T, Li Q, Jin R, You C, Wu P, Shao J, Xia S, Yang M, Han C, Wang X Tags: Curr Stem Cell Res Ther Source Type: research

Stem Cell Therapy: A Promising Approach in Treatment of COVID 19.
This study reviews the characteristics of stem cells and clinical trials which uses stem cells in treating COVID-19. PMID: 33045970 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - October 12, 2020 Category: Stem Cells Authors: Abbaspanah B, Abroun S, Zarrabi M, Mozdgir A, Mollanouri M Tags: Curr Stem Cell Res Ther Source Type: research

Targeted Drug Delivery to Cancer Stem Cells through Nanotechnological Approaches.
Abstract Cancer stem cells (CSCs) are responsible for tumor development, invasion and metastasis and for resistance to chemotherapy and radiotherapy. Therefore, treatment strategies have turned to targeting CSCs, and utilizing nanotechnological approaches to target CSCs has become increasingly fascinating. Functionalized nanoparticles (NPs), such as metallic NPs, liposomes, polymeric NPs, albumin microspheres and nanomicelles, can easily cross the cytoplasmic membrane and accumulate at their targets to continuously release therapeutic agents in response to the characteristics of the tumor microenvironment. Differe...
Source: Current Stem Cell Research and Therapy - October 1, 2020 Category: Stem Cells Authors: Suna W, Chen G, Du F, Li X Tags: Curr Stem Cell Res Ther Source Type: research

Guiding Lineage Specific Differentiation of SHED for Target Tissue/Organ Regeneration.
Abstract Stem cells from human exfoliated deciduous teeth (SHED) are considered one of the most attractive cell sources for tissue engineering due to their easy acquisition with no donor morbidity, ready availability, ability to selfrenew with high proliferation, capacity for multilineage differentiation and immunomodulatory functions. To date, SHED have been shown to be able to differentiate into odonto-/osteoblasts, neuronal cells, endothelial cells, hepatocyte-like cells, chondrocytes, epidermal cells among many other cell types. Accordingly, SHED possess a promising potential to be used in the cell-based thera...
Source: Current Stem Cell Research and Therapy - September 28, 2020 Category: Stem Cells Authors: Han Y, Zhang L, Zhang C, Dissanayaka WL Tags: Curr Stem Cell Res Ther Source Type: research

Comparison of Isolation, Expansion and Cryopreservation Techniques to Produce Stem Cells from Human Exfoliated Deciduous teeth (SHED) with better Regenerative Potential.
Abstract Mesenchymal stem cells (MSCs) are adult stem cells that are gaining worldwide attention for its multi-potential use in tissue engineering-based regenerative medicine. They can be obtained from numerous sources and one of the excellent source is from the dental tissue, such as stem cells that are extracted from the human exfoliated deciduous teeth (SHEDs). SHEDs are considered ideal due to its inherent characteristics, including the capability to proliferate quickly with minimal oncogenesis risk, multipotency capacity and its ability to suppress the immune system. On top of these positive cell traits, SHED...
Source: Current Stem Cell Research and Therapy - September 27, 2020 Category: Stem Cells Authors: Lee SH, Looi CY, Chong PP, Foo JB, Looi QH, Ng CX, Ibrahim Z Tags: Curr Stem Cell Res Ther Source Type: research

Different Aspects of Head and Neck Squamous Cell Carcinoma: Cancer Stem Cells, Their Niche and Targeted Therapy.
Çelebi-Saltik B Abstract Head and Neck Squamous Cell Carcinoma (HNSCC) is categorized as the sixth most common cancer worldwide, with an incidence of more than 830,000 cases per year and a mortality rate of 50%. Tobacco use, alcohol consumption, and Human Papillomavirus infection are the prominent risks for HNSCC. Despite significant developments in the treatment of HNSCC, a high rate of recurrences makes the clinical situation worse and results in poor survival rates. Recent perspectives demonstrate that whereas epithelial transformation plays a crucial role in cancer development, tumor surrounding microe...
Source: Current Stem Cell Research and Therapy - September 20, 2020 Category: Stem Cells Authors: Küçükgüven MB, Çelebi-Saltik B Tags: Curr Stem Cell Res Ther Source Type: research

Extracellular Vesicles Isolated from Mesenchymal Stromal Cells Primed with Hypoxia: Novel strategy in Regenerative Medicine.
Abstract Mesenchymal stromal cells (MSCs) regulate other cell types through a strong paracrine component called the secretome, comprising of several bioactive entities. The composition of the MSCs' secretome is dependent upon the microenvironment in which they thrive, and hence, it could be altered by pre-conditioning the MSCs during in vitro culture. The primary aim of this review is to discuss various strategies that are being used for pre-conditioning of MSCs, also known as "priming of MSCs", in the context of improving their therapeutic potential. Several studies have underscored the importance of ex...
Source: Current Stem Cell Research and Therapy - September 17, 2020 Category: Stem Cells Authors: Pendse S, Kale V, Vaidya A Tags: Curr Stem Cell Res Ther Source Type: research

Potential of Photobiomodulation to Induce Differentiation of AdiposeDerived Mesenchymal Stem Cells into Neural Cells.
CONCLUSION: PBM shows promise as an avenue for effective ADMSCs differentiation into neural cells and their proliferation. Applying PBM with optimized biological factors and chemical inducers may prove to be an effective tool for clinical application. PMID: 32957891 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - September 16, 2020 Category: Stem Cells Authors: Van Rensburg MJ, Abrahamse H, Crous A Tags: Curr Stem Cell Res Ther Source Type: research

Human Exfoliated Deciduous Teeth Stem Cells: Features and Therapeutic Effects on Neurogenerative and Hepatobiliary-Pancreatic Diseases.
Abstract Stem cells can multiply into more cells with similar types in an undifferentiated form and differentiate into other types of cells. The great success and key essence of stem cell technology is the isolation of high-quality mesenchymal stem cells (MSCs) with high potency, either with multipotent or pluripotent property. In this line, stem cells from human exfoliated deciduous teeth (SHEDs) are highly proliferative stem cells from dental pulp and have multipoint differentiation capacity. These cells play a pivotal role in regenerative medicine, such as cell repair associated with neurodegenerative, hepatobi...
Source: Current Stem Cell Research and Therapy - September 16, 2020 Category: Stem Cells Authors: Abdul Wahab NW, Guad RM, Subramaniyan V, Fareez IM, Choy KW, Bonam SR, Selvaraju C, Sim MS, Gopinath SCB, Wu YS Tags: Curr Stem Cell Res Ther Source Type: research

Therapeutic applications of mesenchymal stem cells: A comprehensive review.
Abstract Mesenchymal stem cells (MSCs) are one of the most common types of adult stem cells. While MSCs are traditionally isolated from bone marrow, over the last few years, they have also been found in many other adult tissues such as liver, cord blood, placenta, dental pulp and adipose tissue. They have been investigated as a marvelous cell source for tissue regeneration and suggested as a therapy in non-autologous application, because of lack of MHC class II expression. For the past several decades, furthermore, MSCs show promise as a therapeutic strategy in medicine. Many advantages such as self-renewal, in vi...
Source: Current Stem Cell Research and Therapy - September 13, 2020 Category: Stem Cells Authors: Samadi P, Saki S, Khoshinani HM, Sheykhhasan M Tags: Curr Stem Cell Res Ther Source Type: research

Mini-review; deriving avian stem cells by small molecules.
Abstract Avian embryos and related cell lines have found wide applications in basic and applied sciences. The embryonated egg is a great host for monoclonal antibodies and recombinant proteins. Avian celllines derived from embryonated eggs have been used for the product ion of transgenic birds and virusinoculationin order tovaccine preparation. Hitherto, many efforts have been invested to develop efficient avian stem cell culture. Under the conventional conditions, there are various challenges such as the type of feeder layers, conditioned medium,serum, and growth factors. Researchers have investigated different c...
Source: Current Stem Cell Research and Therapy - August 30, 2020 Category: Stem Cells Authors: Farzaneh M Tags: Curr Stem Cell Res Ther Source Type: research

Stem Cells: In Sickness and in Health.
Abstract Stem cells are undifferentiated cells with the ability to proliferate and convert to different types of differentiated cells that make up the various tissues and organs in the body. They exist both in embryos as pluripotent stem cells that can differentiate into the three germ layers and as multipotent or unipotent stem cells in adult tissues to aid in repair and homeostasis. Perturbations in these cells' normal functions can give rise to a wide variety of diseases. In this review, we discuss the origin of different stem cell types, their properties and characteristics, their role in tissue homeostasis, c...
Source: Current Stem Cell Research and Therapy - August 30, 2020 Category: Stem Cells Authors: Bahmada HF, Elajami MK, Daouk R, Jalloul H, Darwish B, Chalhoub RM, Assi S, Chamaa F, Abou-Kheir W Tags: Curr Stem Cell Res Ther Source Type: research

A Systematic Review and Meta-analysis : Safety and Efficacy of Mesenchymal stem Cells Therapy for Heart Failure.
This study aimed to assess the safety and efficacy of MSCs therapy compared to the placebo in heart failure patients. METHODS: We searched PubMed, Embase, Cochrane library systematically, with no language restrictions. Randomized controlled trials(RCTs) assessing the influence of MSCs treatment function controlled with placebo in heart failure were included in this analysis. We included RCTs with data on safety and efficacy in patients with heart failure after mesenchymal stem cell transplantation. Two investigators independently searched the articles, extracted data, and assessed the quality of the included studies. ...
Source: Current Stem Cell Research and Therapy - August 19, 2020 Category: Stem Cells Authors: Shen T, Xia L, Dong W, Wang J, Su F, Niu S, Wang Q, Fang Y Tags: Curr Stem Cell Res Ther Source Type: research

A Promising Strategy for Non-Arteritic Anterior Ischemic Optic Neuropathy: Intravitreal Mesenchymal Stem Cell Exosome.
Abstract Non-arteritic anterior ischemic optic neuropathy (NAION) is a leading cause of optic nerve-related permanent visual impairment among individuals of over 50 years of age after glaucoma. Because of perplexing disorder regarding its pathogenesis, there is still no widely accepted and established treatment plan. Mesenchymal stem cells (MSCs) are one of the rare stem cell types that therapeutic agents for immunomodulation and ischemic tissue repair in clinical practice. However, there are certain disadvantages in using MSCs, such as potential tumorigenicity, need for autologous collection, and short survival t...
Source: Current Stem Cell Research and Therapy - August 13, 2020 Category: Stem Cells Authors: Li D, Gong Y Tags: Curr Stem Cell Res Ther Source Type: research

Current Trends on Haemopoietic Stem Cells.
Abstract Advances in single cell technology and genetic mouse models have resulted in the identification of new types of haemopoietic stem cells(HSC) , resulting in baffling observations, suggesting a reconsideration of the long-held notion that all hematopoietic cells in the adult are derived from HSCs. The existence of long-lived HSC-independent hematopoiesis has led to the conclusion that despite the single hierarchical differentiation route that generates functional blood types, other differenciation routes exist invivo. Heterogeneity in the HSC population and the evolving knowledge around HSC has translated t...
Source: Current Stem Cell Research and Therapy - July 28, 2020 Category: Stem Cells Authors: Okeke C, Silas U, Okeke C, Chikwendu C Tags: Curr Stem Cell Res Ther Source Type: research

The Promise of Mesenchymal stem cells therapy for acute Respiratory Distress Syndrome Caused by COVID-19.
Abstract The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) since Dec 2019, known as COVID-19 or 19-nCoV, has led to a major concern of the potential for not only an epidemic but a pandemic in China and now it seems to be a public health problem all over the world. The general mortality rate of the COVID-19 was about 3%. However, the mortality risk seems to be a significant increase in elderly and cases with chronic disease, who are more likely to develop into acute respiratory distress syndrome (ARDS). There still lacks effective methods for ARDS of COVID-19 patients and the prognosis wa...
Source: Current Stem Cell Research and Therapy - July 28, 2020 Category: Stem Cells Authors: Gu J, Zhao Q, Han Z, Han Z Tags: Curr Stem Cell Res Ther Source Type: research

Challenges in the Management of Pregnancy and Lactation Associated Osteoporosis: Literature Review and Retrospective Study.
Abstract Pregnancy and lactation associated osteoporosis [PLO] is a rare and special form of osteoporosis, which is poorly known with regard to its etiology, pathophysiology and therapy. However, PLO can cause vertebral compression fractures [VCFs] and height loss, which could cause the further kyphosis of the spine. Therefore PLO should be taken into account in the differential diagnosis when a woman presents with severe back pain during or after pregnancy.In our current study, we reviewed the novel literatures that demonstrate the current understanding of and treatment for PLO. In addition, we retrospectively st...
Source: Current Stem Cell Research and Therapy - July 28, 2020 Category: Stem Cells Authors: Yang B, Kong L, Hao D Tags: Curr Stem Cell Res Ther Source Type: research

Mesenchymal Stem Cell Therapy for Oral Inflammatory Diseases: Research Progress and Future Perspectives.
Abstract Mesenchymal stem cell (MSC) therapy for clinical diseases associated with inflammation and tissue damage has become a progressive treatment strategy. MSCs have unique biological functions, such as homing, immune regulation, and differentiation capabilities, which provide the prerequisites for treatment of clinical diseases. Oral diseases are often associated with abnormal immune regulation and epithelial tissue damage. In this review, we summarize previous studies that use MSC therapy to treat various oral inflammatory diseases, including oral ulceration, allergic diseases, chemo/radiotherapy-induced oral...
Source: Current Stem Cell Research and Therapy - July 25, 2020 Category: Stem Cells Authors: Gong W, Wang F, He Y, Heath B, Zeng X, Zhang D, Chen Q Tags: Curr Stem Cell Res Ther Source Type: research

Application of Physical Stimulation in Stem Cell-based Tissue Engineering.
PMID: 32698756 [PubMed - in process] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - July 24, 2020 Category: Stem Cells Authors: Lv Y Tags: Curr Stem Cell Res Ther Source Type: research

Regenerative medicine under control of 3D scaffolds: Current state and progress of tissue scaffolds.
Abstract Currently, combining stem cells [SCs] with biomaterial scaffolds provides a promising strategy for the future of biomedicine and regenerative medicine [RG]. The cells need similar substrates of extra cellular matrix [ECM] for normal tissue development that signifies the importance of three dimensional [3D] scaffolds to determine cell fate. Herein, we present the great importance and also positive contributions of corresponding 3D scaffolds on cell functions including cell interactions, cell migrations, and nutrient delivery. Further on, the synthesis techniques which are recruited to fabricate the 3D scaf...
Source: Current Stem Cell Research and Therapy - July 18, 2020 Category: Stem Cells Authors: Golchin A, Farzaneh S, Porjabbar B, Sadegian F, Estaji M, Ranjbarvan P, Kanafimahbob M, Ranjbari J, Salehi-Nik N, Hosseinzadeh S Tags: Curr Stem Cell Res Ther Source Type: research

From Embryo to Adult: One Carbon Metabolism in Stem Cells.
-Saltik B Abstract Stem cells are undifferentiated cells with self-renewal property with varying differentiation potential that allow the regeneration of tissue cells of an organism throughout adult life beginning with embryonic development. Through the asymmetric cell divisions, each stem cell replicates itself and produces an offspring identical with the mother cell, and a daughter cell that posses the characteristics of a progenitor cell and commits to a specific lineage to differentiate into tissue cells to maintain homeostasis. To maintain a pool of stem cells to ensure tissue regeneration and homeostasis, it...
Source: Current Stem Cell Research and Therapy - July 11, 2020 Category: Stem Cells Authors: Altundag Ö, Çelebi-Saltik B Tags: Curr Stem Cell Res Ther Source Type: research

The regulation of E3 ubiquitin ligases Cbl and its cross talking in bone homeostasis.
Abstract The E3 ubiquitin ligases Cbl has been found play an important role in regulating cellular proliferation and migration. Whereas the excessive differentiation of osteoclast and/or its over expressing of resorptive functions could lead the pathological bone homeostasis by overly bone matrix degradation. Since the first time of the important role of Cbl in the regulating osteoclast differentiation (also named osteoclastogenesis) has been reported in decades ago. The extensively studies have been conducted for in-depth exploring the Cbl's definite role during osteoclastogenesis, as well as its cross talking wi...
Source: Current Stem Cell Research and Therapy - July 11, 2020 Category: Stem Cells Authors: Yang X, Hao D, He B Tags: Curr Stem Cell Res Ther Source Type: research

Recent approaches for isolating and culturing mouse bone marrow-derived mesenchymal stromal stem cells.
Abstract The isolation and culture of murine bone marrow-derived mesenchymal stromal stem cells (mBMSCs) have attracted great interest in terms of the pre-clinical applications of stem cells in tissue engineering and regenerative medicine. In addition, culturing mBMSCs is important for studying the molecular mechanisms of bone remodelling using relevant transgenic mice. Several factors have created challenges in the isolation and high-yield expansion of homogenous mBMSCs; these factors include low frequencies of bone marrow-derived mesenchymal stromal stem cells (BMSCs) in bone marrow, variation among inbred mouse...
Source: Current Stem Cell Research and Therapy - July 7, 2020 Category: Stem Cells Authors: Abdallah BM, Khattab HM Tags: Curr Stem Cell Res Ther Source Type: research

Elucidating the Pivotal Role of Immune Players in the Management of COVID-19: Focus on Mesenchymal Stem Cells and Inflammation.
Abstract The world is currently engulfed with a viral disease with no cure. So, far, millions of people are infected with the virus across the length and breadth of world with thousand losing their lives each passing day. The WHO is February 2020 classified the virus as a coronavirus and the name Coronavirus-19 (CoV-19) was offered to the virus. The disease caused by the virus was termed coronavirus disease-19 (COVID-19). The pathogenesis of COVID-19 is associated with elevation of several immune plays as well as inflammatory factors which contributes to cytokine storms. Currently, the detection of CoV-19 RNA is t...
Source: Current Stem Cell Research and Therapy - July 4, 2020 Category: Stem Cells Authors: Richard SA, Kampo S, Sackey M, Hechavarria ME, Buunaaim ADB, Kuugbee ED, Anabah TW Tags: Curr Stem Cell Res Ther Source Type: research

Differentiation of Human Induced Pluripotent Stem Cells Into Male Germ Cells.
Abstract Infertility is defined as not being able to become pregnant or to conceive a child after one year or longer of regular unprotected intercourse. Male infertility refers to a male's inability to cause pregnancy that can result from deficiencies in semen quality, sperm concentration, or abnormal sperm function. Till now, there are few effective methods for the treatment of a couple with male infertility. In the past few years, stem cell-based therapy as a promising strategy has emerged for the treatment of male infertility. Human pluripotent stem cells (hPSCs) can self-renew and differentiate into any type o...
Source: Current Stem Cell Research and Therapy - July 4, 2020 Category: Stem Cells Authors: Zhao N, Sheng M, Wang X, Li Y, Farzaneh M Tags: Curr Stem Cell Res Ther Source Type: research

Transplantation of Stem Cells as a Potential Therapeutic Strategy in Neurodegenerative Disorders.
Abstract Stem cells are considered to have significant capacity to differentiate into various cell types in humans or animals. Unlike specialized cells, these cells can proliferate several times to produce millions of cells. Nowadays, pluripotent stem cells are important candidates to provide a renewable source for replacement of cells in tissues of interest. The damage to neurons and glial cells in the brain or spinal cord is present in neurological disorders such as Amyotrophic lateral sclerosis, stroke, Parkinson's disease, multiple sclerosis, Alzheimer's disease, Huntington's disease, spinal cord injury, lysos...
Source: Current Stem Cell Research and Therapy - June 27, 2020 Category: Stem Cells Authors: Ebrahimi T, Abasi M, Seifar F, Eyvazi S, Hejazi MS, Tarhriz V, Montazersaheb S Tags: Curr Stem Cell Res Ther Source Type: research

The role of ginsenoside Rb1 in bone homeostasis.
Abstract Panax ginseng,as a well-known medical plant with economic value,has a long history of use for treating various diseases in Asian. Accumulating clinical and experimental evidences suggest that ginsenoside Rb1,which is the major bioactive components of the plant, have a variety of biological effects on treating aging related diseases such as: cardiovascular disease (CVD), central nervous system disease (CNSD), and osteoporosis (OP). Recently, considerable attentions have been focused on ginsenoside Rb1 as an anti-osteoporosis agent. It has been reported that ginsenoside Rb1 could promote osteoblast di...
Source: Current Stem Cell Research and Therapy - June 27, 2020 Category: Stem Cells Authors: Yang B, Zhao S, Yan L Tags: Curr Stem Cell Res Ther Source Type: research

Can Functionally Mature Islet β-Cells Be Derived from Pluripotent Stem Cells? - A Step Towards Ready-To-Use β-Cells in Type 1 Diabetes.
Can Functionally Mature Islet β-Cells Be Derived from Pluripotent Stem Cells? - A Step Towards Ready-To-Use β-Cells in Type 1 Diabetes. Curr Stem Cell Res Ther. 2020 Jun 21;: Authors: Khand BK, Bhonde RR Abstract Pluripotent Stem Cells [PSCs] are emerging as an excellent cellular source for treatment of many degenerative diseases such as diabetes, ischemic heart failure, Alzheimer's disease. PSC-derived pancreatic islet β-cells appear to be as a promising therapy for type 1 diabetes patients with impaired β-cell function. Several protocols have been developed to derive β-cells...
Source: Current Stem Cell Research and Therapy - June 20, 2020 Category: Stem Cells Authors: Khand BK, Bhonde RR Tags: Curr Stem Cell Res Ther Source Type: research

Advances in small molecules in cellular reprogramming: effects, structures, and mechanisms.
Abstract The method of cellular reprogramming using small molecules involves manipulation of somatic cells to generate desired cell types under chemically limited conditions, thus avoiding the ethical controversy of embryonic stem cells and the potential hazards of gene manipulation. The combinations of small molecules and their effects on mouse and human somatic cells are similar. Several small molecules, including CHIR99021, 616452, A83-01, SB431542, forskolin, tranylcypromine and valproic acid [VPA], have been frequently used in reprogramming of mouse and human somatic cells. This indicated that the reprogrammi...
Source: Current Stem Cell Research and Therapy - June 20, 2020 Category: Stem Cells Authors: Zeng J, Li Y, Ma Z, Hu M Tags: Curr Stem Cell Res Ther Source Type: research

The Role of MicroRNAs in the Induction of Pancreatic Differentiation.
Abstract Stem cell-based therapy is one of the therapeutic options with promising results in the treatment of diabetes. Stem cells from various sources are expanded and induced to generate the cells capable of secreting insulin. These insulinproducing cells [IPCs] could be used as an alternative to islets in the treatment of patients with diabetes. Soluble growth factors, small molecules, gene-encoding transcription factors, and microRNAs [miRNAs] are commonly used for the induction of stem cell differentiation. MiRNAs are small non-coding RNAs with 21-23 nucleotides that are involved in the regulation of gene exp...
Source: Current Stem Cell Research and Therapy - June 20, 2020 Category: Stem Cells Authors: Sabouri E, Rajabzaseh A, Enderami SE, Saburi E, Soleimanifar F, Barati G, Rahmati M, Khamisipour G, Enderami SE Tags: Curr Stem Cell Res Ther Source Type: research

Mesenchymal Stem Cell-based Therapy for COVID-19: Possibility and Potential.
In this study, we summarized the clinical outcomes of MSCs for ARDS patients in some preclinical and clinical studies, and discussed the application of MSCs for patients with COVID-19 in China and the related important issues with MSCs use during the outbreak. PMID: 32479246 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - May 31, 2020 Category: Stem Cells Authors: Xiong J, Bao L, Qi H, Feng Z, Shi Y Tags: Curr Stem Cell Res Ther Source Type: research

Nanomaterials-based Cell Osteogenic Differentiation and Bone Regeneration.
Abstract With the rapid development of nanotechnology, various nanomaterials have been applied to bone repair and regeneration. Due to the unique chemical, physical and mechanical properties, nanomaterials could promote stem cells osteogenic differentiation, which has great potentials in bone tissue engineering and exploiting nanomaterials-based bone regeneration strategies. In this review, we summary current nanomaterials with osteo-induction ability, which could be potentially applied to bone tissue engineering. Meanwhile, the unique properties of these nanomaterials and their effects on stem cell osteogenic dif...
Source: Current Stem Cell Research and Therapy - May 19, 2020 Category: Stem Cells Authors: Zhang T, Gao Y, Cui W, Li Y, Xiao D, Zhou R Tags: Curr Stem Cell Res Ther Source Type: research