A review on stem cell therapy for neuropathic pain.
In conclusion, this review suggests that stem cell therapy can be a novel approach for the treatment of neuropathic pain. PMID: 32056531 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - February 13, 2020 Category: Stem Cells Authors: Asgharzade S, Talaei A, Farkhondeh T, Forouzanfar F Tags: Curr Stem Cell Res Ther Source Type: research

Stem cell aging in lifespan and disease: A state-of-the-art review.
Abstract Aging considered as inevitable changes at different levels of genome, cell, and organism. From the accumulation of DNA damages to imperfect protein homeostasis, altered cellular communication and exhaustion of stem cells, aging is a major risk factor for many prevalent diseases, such as cancer, cardiovascular disease, pulmonary disease, diabetes, and neurological disorders. The cells are dynamic systems which through a cycle of processes such as replication, growth, and death could replenish the bodies' organs and tissues, keeping an entire organism in optimal working order. In many different tissues, adu...
Source: Current Stem Cell Research and Therapy - February 12, 2020 Category: Stem Cells Authors: Sameri S, Samadi P, Dehghan R, Salem E, Fayazi N, Amini R Tags: Curr Stem Cell Res Ther Source Type: research

Application of Nanomaterials in the Treatment and Diagnosis of Ophthalmology Diseases.
Abstract Eye diseases often lead to impaired vision and seriously affect the daily life of patients. Local administration of ophthalmic drugs is one of the most important approaches for the treatment of ophthalmic diseases. However, due to the special biochemical environment of the ocular tissue and the existence of many barriers, the bioavailability of conventional ophthalmic preparations in the eye is very low. Nanomaterials can be utilized as carriers of drugs, which can improve the absorption, distribution, metabolism and bioavailability of drugs in eyes. Nanomaterials also have the advantages of small size, s...
Source: Current Stem Cell Research and Therapy - February 9, 2020 Category: Stem Cells Authors: Liu N, Wu Q, Liu Y, Li J, Fu G, Ji P Tags: Curr Stem Cell Res Ther Source Type: research

The cell engraftment hypothesis of cardiac repair.
Abstract Heart failure is a significant source of morbidity and mortality around the world. Recently, cell therapy has garnered much attention as a means of improving cardiac function after injury. Despite years of study, a growing list of failed efficacy trials has led many to question the translatability of preclinical work. In this review, we critically evaluate the evidence supporting the need for transplanted cells to engraft and persist in the injured heart (the cell engraftment hypothesis). We explore how the complex interplay between cell retention, persistence and paracrine potency explain many of the rec...
Source: Current Stem Cell Research and Therapy - February 5, 2020 Category: Stem Cells Authors: Davis DR Tags: Curr Stem Cell Res Ther Source Type: research

Stem-cell derived exosomes for treatment of osteoarthritis.
This article summarizes the current advances and challenges in exosomes for OA, which may provide reference for further research. PMID: 32026786 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - February 5, 2020 Category: Stem Cells Authors: Ke Z, Zhu J Tags: Curr Stem Cell Res Ther Source Type: research

Biological Responses of Stem Cells to Photobiomodulation Therapy.
CONCLUSION: The findings of this review suggest that PBMT -based regenerative medicine could be a useful tool for future advances in tissue engineering and cell therapy. PMID: 32013851 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - February 4, 2020 Category: Stem Cells Authors: Khorsandi K, Hosseinzadeh R, Abrahamse H, Fekrazad R Tags: Curr Stem Cell Res Ther Source Type: research

Roles of hematopoietic stem and progenitor cells in ischemic cardiovascular disease.
Abstract Macrophage proliferation and skewed myelopoiesis-induced monocytosis, as well as neutrophils, enhance the generation of atherogenic inflammatory cells in a lesion area, leading to plaque formation and cardiovascular disease (CVD). Among all risk factors, accumulated data have shown that hyperlipidemia activates hematopoietic stem/progenitor cells (HSPCs) in the bone marrow (BM) niche. Recently, proliferation of granulocyte-monocyte progenitors (GMPs) has been demonstrated to drive skewed myelopoiesis, while HSPCs remain quiescent. In this review, we discuss how HSPCs and GMPs participate in atherosclerosi...
Source: Current Stem Cell Research and Therapy - January 29, 2020 Category: Stem Cells Authors: Yan C, Li YZ, Luo XM, Quan XJ, Feng YM Tags: Curr Stem Cell Res Ther Source Type: research

A Concise Review on Mesenchymal Stem Cells for Tissue Engineering with a Perspective on Ocular Surface Regeneration.
Abstract Organ and tissue transplantation are limited by scarcity of donated organs or tissue sources. The success of transplantation is limited by the risk of disease transmission and the immunological-related rejection. There is a need for new strategies and innovative solutions to make transplantation readily available, safer and with less complications to increase the success rates. Accelerating progress in stem cell biology and biomaterials development have pushed tissue and organ engineering to a higher level. Among stem cells repertoire, mesenchymal stem cells (MSC) are gaining interest and recognized as a ...
Source: Current Stem Cell Research and Therapy - January 29, 2020 Category: Stem Cells Authors: Salih M, Shaharuddin B, Abdelrazeg S Tags: Curr Stem Cell Res Ther Source Type: research

'Effects of electrical stimulation on stem cells'.
Abstract Recent interest in developing new regenerative medicine- and tissue engineering-based treatments has motivated researchers to develop strategies for manipulating stem cells to optimize outcomes in these potentially, game-changing treatments. Cells communicate with each other, and with their surrounding tissues and organs via electrochemical signals. These signals originate from ions passing back and forth through cell membranes and play a key role in regulating cell function during embryonic development, healing, and regeneration. To study the effects of electrical signals on cell function investigators h...
Source: Current Stem Cell Research and Therapy - January 29, 2020 Category: Stem Cells Authors: Heng W, Bhavsar M, Zhihua H, Barker JH Tags: Curr Stem Cell Res Ther Source Type: research

Importance of stem cell migration and angiogenesis study for regenerative cell-based therapy: A review.
Abstract Stem cells play an essential role in maintaining homeostasis, as well as participating in new tissue regeneration. Over the past 20 years, a great deal of effort has been made to investigate the behaviour of stem cells to enable their potential use in regenerative medicine. However, a variety of biological characteristics is known to exist among the different type of stem cells due to variations in methodological approach, formulation of cell culture medium, isolation protocol and cellular niches, as well as species variation. In recent years, cell-based therapy emerges as one of the advanced techniques a...
Source: Current Stem Cell Research and Therapy - January 27, 2020 Category: Stem Cells Authors: Aziz NS, Yusop N, Ahmad A Tags: Curr Stem Cell Res Ther Source Type: research

A review of Evaluating of Hematopoietic Stem Cells Derived from Umbilical Cord Blood ׳s Expansion and Homing.
A review of Evaluating of Hematopoietic Stem Cells Derived from Umbilical Cord Blood׳s Expansion and Homing. Curr Stem Cell Res Ther. 2020 Jan 23;: Authors: Islami M, Soleimanifar F Abstract Transplantation of hematopoietic stem cells (HSCs) derived from umbilical cord blood (UCB) has been taken into account as a therapeutic approach in patients with hematologic malignancies. Unfortunately, there are limitations concerning HSC transplantation (HSCT) including (a) low contents of UCB-HSCs in a single unit of UCB and (b) defects in UCB-HSC homing to their niche. Therefore, delays are observed in hemato...
Source: Current Stem Cell Research and Therapy - January 23, 2020 Category: Stem Cells Authors: Islami M, Soleimanifar F Tags: Curr Stem Cell Res Ther Source Type: research

The non-coding side of cardiac differentiation and regeneration.
Abstract Large scale projects such as FANTOM and ENCODE, led to a revolution in our comprehension of the mammalian transcriptomes by revealing that ~53% of the produced RNAs do not encode for proteins. These transcripts, defined as noncoding RNAs (ncRNAs), constitute a heterogeneous group of molecules which can be categorized in two main classes, namely small and long, according to their length. In animals, the first class includes Piwi-interacting RNAs (piRNAs), small interfering RNAs (siRNAs) and microRNAs (miRNAs). Among them, the best characterized subgroup is represented by miRNAs, which are known to regulate...
Source: Current Stem Cell Research and Therapy - January 23, 2020 Category: Stem Cells Authors: Pagano F, Calicchio A, Picchio V, Ballarino M Tags: Curr Stem Cell Res Ther Source Type: research

Salinomycin suppresses tumorigenicity of liver cancer stem cells and Wnt/beta-catenin signaling.
CONCLUSION: Salinomycin could suppress stemness properties and induce differentiation of LCSCs through the Wnt/β-catenin signaling pathway, which provides evidence that salinomycin may serve as a potential drug for liver cancer therapy targeting LCSCs in the clinic. PMID: 31971116 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - January 23, 2020 Category: Stem Cells Authors: Liu Q, Sun J, Luo Q, Ju Y, Song G Tags: Curr Stem Cell Res Ther Source Type: research

Mini review; differentiation of human pluripotent stem cells into oocytes.
Abstract Primary ovarian insufficiency (POI) is one of the main diseases causing female infertility that happens in about 1% of women between 30-40 years old. There are few effective methods for the treatment of women with POI. In the past few years, stem cell-based therapy as one of the most highly investigated new therapies has emerged as a promising strategy for the treatment of POI. Human pluripotent stem cells (hPSCs) can self-renew indefinitely and differentiate into any type of cell. Human embryonic stem cells (hESCs) as a type of pluripotent stem cells are the most powerful candidate for the treatment of P...
Source: Current Stem Cell Research and Therapy - January 15, 2020 Category: Stem Cells Authors: Wang G, Farzaneh M Tags: Curr Stem Cell Res Ther Source Type: research

Cell Senescence in Cardiac Repair and Failure.
Abstract Although the lack of a robust cardiomyocyte proliferative response has been considered to be a crucial determinant of cardiac pathology and Heart Failure in adult mammalians, the emerging picture is that myocardial regeneration is a complex phenotype involving many actors, including acute cellular senescence and inflammation. However, three major and interconnected events occur in response to tissue injury: loss of protein homeostasis, accumulation of dysfunctional mitochondria and chronic inflammation. These events blunt the reparative response of the heart, are associated with the accumulation of chroni...
Source: Current Stem Cell Research and Therapy - January 6, 2020 Category: Stem Cells Authors: Rolle IG, Crivellari I, Caragnano A, Cervellin C, Aleksova A, Cesselli D, Beltrami AP Tags: Curr Stem Cell Res Ther Source Type: research

A brief analysis of mesenchymal stem cells as biological drugs for the treatment of acute-on-chronic liver failure (ACLF): safety and potency.
Abstract Acute-on-chronic liver failure (ACLF) is characterized by acute exacerbation of chronic hepatitis, organ failure, high mortality, and poor prognosis. At present, the clinical methods of treatment include comprehensive treatment with medicines, artificial liver system, and orthotopic liver transplantation (OLT), and of these, OLT is considered the most effective treatment for ACLF. However, it is difficult for ACLF patients to benefit from OLT due to the shortage of liver donors, high cost, unpredictable postoperative complications, and long-term use of immunosuppressive drugs; therefore, it is important t...
Source: Current Stem Cell Research and Therapy - January 1, 2020 Category: Stem Cells Authors: Feng Y, Wang AT, Jia HH, Zhao M, Yu H Tags: Curr Stem Cell Res Ther Source Type: research

Preparation and Application of Magnetic Responsive Materials in Bone Tissue Engineering.
Abstract At present, many kinds of materials are used for bone tissue engineerings, such as polymer materials, metals, etc., which in general have good biocompatibility and mechanical properties. However, these materials cannot be controlled artificially after implantation, which may result in poor repair performance. The appearance of the magnetic response material enables the scaffolds to have the corresponding ability to the external magnetic field. Within the magnetic field, the magnetic response material can achieve the targeted release of the drug, improve the performance of the scaffold, and further have a ...
Source: Current Stem Cell Research and Therapy - January 1, 2020 Category: Stem Cells Authors: Li S, Wei C, Lv Y Tags: Curr Stem Cell Res Ther Source Type: research

Mini review: Recent advances in the cell-based therapies for cardiac regeneration.
Abstract Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality globally, and traditional pharmaceutical and surgical interventions delay the progression of CVDs. Recently, stem cell therapy has emerged as a promising candidate for treating and preventing heart failure. Increasing efforts have been devoted towards the exploration and identification of potential cell types to repair the injured heart, such as skeletal myoblasts, embryonic, induced pluripotent, bone marrow-derived, mesenchymal, and resident cardiac stem cells. In addition, the direct reprogramming of cardiac fibroblasts into...
Source: Current Stem Cell Research and Therapy - January 1, 2020 Category: Stem Cells Authors: Luo L, Li TS Tags: Curr Stem Cell Res Ther Source Type: research

The Role of lncRNAs in osteogenic differentiation of bone marrow mesenchymal stem cells.
Abstract Bone marrow mesenchymal stem cells (BMSCs) are one of the earliest cells found in the bone marrow, and they can differentiate into osteoblasts, chondrocytes, adipocytes and even myoblasts, and are therefore considered pluripotent cells. Because of their multipotential differentiation, self-renewal, immunomodulation and other potential, BMSCs have become an important source of seed cells for gene therapy, tissue engineering, cell replacement therapy and regenerative medicine. Long non-coding RNA (lncRNA) is an RNA molecule greater than 200 nucleotides in length that is expressed in a variety of species, in...
Source: Current Stem Cell Research and Therapy - December 26, 2019 Category: Stem Cells Authors: Wang J, Liu S, Shi J, Liu H, Li J, Zhao S, Yi Z Tags: Curr Stem Cell Res Ther Source Type: research

Kidney Regeneration: Stem Cells as a New Trend.
Abstract Renal disease is a major worldwide public health problem that affects one in ten people. Renal failure is caused by irreversible loss of the structural and functional units of kidney (nephrons) due to acute and chronic injuries. In humans, new nephrons (nephrogenesis) are generated until the 36th week of gestation and no new nephron develop after birth. However, in rodents, nephrogenesis persists until the immediate postnatal period. The postnatal mammalian kidney can partly repair their nephrons. The kidney uses intrarenal and extra-renal cell sources for maintenance and repair. Currently, it is believed...
Source: Current Stem Cell Research and Therapy - December 17, 2019 Category: Stem Cells Authors: Ahmadi A, Rad NK, Ezzatizadeh V, Moghadasali R Tags: Curr Stem Cell Res Ther Source Type: research

Advancing a stem cell therapy for age-related macular degeneration.
Abstract The retinal pigment epithelium [RPE] is a multifunctional monolayer located at the back of the eye required for the survival and function of the light-sensing photoreceptors. In Age-related Macular Degeneration [AMD], the loss of RPE cells leads to photoreceptor death and permanent blindness. RPE cell transplantation aims to halt or reverse vision loss by preventing the death of photoreceptor cells and is considered one of the most viable applications of stem cell therapy in the field of regenerative medicine. Proof-of-concept of RPE cell transplantation for treating retinal degenerative disease, such as ...
Source: Current Stem Cell Research and Therapy - December 17, 2019 Category: Stem Cells Authors: O'Neill HC, Limnios LJ, Barnett NL Tags: Curr Stem Cell Res Ther Source Type: research

Applicability of Low-Intensity Vibrations as a Regulatory Factor on Stem and Progenitor Cell Populations.
Abstract Persistent and transient mechanical loads can act as biological signals on all levels of an organism. It is therefore not surprising that most cell types can sense and respond to mechanical loads, similar to their interaction with biochemical and electrical signals. Presence or absence of mechanical forces can be an important determinant of form, function and health of many tissue types. Along with naturally occurring mechanical loads, it is possible to manipulate and apply external physical loads on tissues in biomedical sciences, either for prevention or treatment of catabolism related to many factors, ...
Source: Current Stem Cell Research and Therapy - December 12, 2019 Category: Stem Cells Authors: Baskan O, Karadas O, Mese G, Ozcivici E Tags: Curr Stem Cell Res Ther Source Type: research

Will tissue-engineering strategies bring new hope for the reconstruction of nasal septal cartilage?.
Abstract The nasal septal cartilage plays an important role during the growth of midface and as a vertical strut preventing the collapse of the nasal bones. The repair of nasal cartilage defects remains a major challenge in reconstructive surgery. The tissue engineering strategy in the development of tissue has opened a new perspective to generate functional tissue for transplantation. Given the poor regenerative properties of cartilage and a limited amount of autologous cartilage availability, intense interest has evoked for tissue engineering approaches for cartilage development to provide better outcomes for pa...
Source: Current Stem Cell Research and Therapy - December 12, 2019 Category: Stem Cells Authors: Bagher Z, Asgari N, Bozorgmehr P, Kamrava SK, Alizadeh R, Seifalian A Tags: Curr Stem Cell Res Ther Source Type: research

Novel Therapeutics Against Breast Cancer Stem Cells by Targeting Surface Markers and Signaling Pathways.
CONCLUSION: BCSCs involved in cancer pathogenesis, therapy resistance and cancer recurrence. Thus, it is suggested that a multi-dimensional therapeutic approach by targeting surface markers and aberrantly activated signaling pathways of BCSCs alone or in combination with each other could really be worthwhile in the treatment of breast cancer. PMID: 31808385 [PubMed - in process] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - December 8, 2019 Category: Stem Cells Authors: Das PK, Rakib MA, Khanam JA, Pillai S, Islam F Tags: Curr Stem Cell Res Ther Source Type: research

Nanocarrier mediated siRNA delivery targeting stem cell differentiation.
Abstract Stem cell based regenerative medicine holds exceptional therapeutic potential and hence the development of efficient techniques to enhance control over the rate of differentiation has been the focus of active research. One of the strategies to achieve this involves delivering siRNA into stem cells and exploiting the RNA interference (RNAi) mechanism. Transport of siRNA across the cell membrane is a challenge due to its anionic property, especially in primary human cells and stem cells. Moreover, naked siRNA incites immune responses, may cause off-target effects, exhibits low stability and is easily degrad...
Source: Current Stem Cell Research and Therapy - December 1, 2019 Category: Stem Cells Authors: Fernandes F, Kotharkar P, Chakravorty A, Kowshik M, Talukdar I Tags: Curr Stem Cell Res Ther Source Type: research

Effectiveness of Stem Cell Therapy in Treatment of Ovarian Disorders and Female Infertility: A Systematic Review.
CONCLUSION: The evidence suggests that stem cell-based therapies could be considered as an alternative modality to deal with women undergoing POI. PMID: 31746298 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - November 19, 2019 Category: Stem Cells Authors: Ahmadian S, Mahdipour M, Pazhang M, Sheshpari S, Mobarak H, Bedate AM, Rahbarghazi R, Nouri M Tags: Curr Stem Cell Res Ther Source Type: research

Current Research and Use of Mesenchymal Stem Cells in the Therapy of Autoimmune Diseases.
Abstract Mesenchymal Stem Cells (MSCs) represent a heterogeneous group of self-renewal, multipotent non-hematopoietic stem cells, which display profound immunomodulatory functions and promising therapeutic effects. Autoimmune diseases, which result from an aberrant immune response to selfantigens, can be detrimental to nearly all body tissues. With the advance in developing a novel treatment, including biological agents, it is still impossible to cure autoimmune disorders. Recent studies demonstrate the remarkable therapeutic effectiveness of MSCs towards a wide array of autoimmune diseases. In this review, the im...
Source: Current Stem Cell Research and Therapy - November 16, 2019 Category: Stem Cells Authors: Chen Y, Yu Q, Hu Y, Shi Y Tags: Curr Stem Cell Res Ther Source Type: research

Notch Signaling in Mammalian Intestinal Stem Cells: Determining Cell Fate and Maintaining Homeostasis.
Abstract The intestine serves mainly as a place for digestion and absorption and functions as an immune and endocrine organ. Intestinal stem cells (ISCs) play critical roles in the maintenance of intestinal homeostasis and regeneration, and a complex of signaling pathways is involved in these processes. The Notch signaling pathway is induced via distinct cell-to-cell connections, which are activated through the binding of the Notch ligand on the surface of niche cells to the Notch receptor on ISCs. Numerous studies have shown the central importance of Notch signaling in the proliferation and differentiation of ISC...
Source: Current Stem Cell Research and Therapy - November 16, 2019 Category: Stem Cells Authors: Liang SJ, Li XG, Wang XQ Tags: Curr Stem Cell Res Ther Source Type: research

Breast milk stem cells survive in the neonate's gut, enter into the neonate circulation and are adapted into the body.
Abstract The stem cell exchange during pregnancy is thought to remain chimeras for life. Few studies recently revealed that maternal transfer of viable stem cells to the offspring continues even after birth during breastfeeding. Some of these stem cells are likely to integrate into different organs (brain, blood, kidneys, and pancreas), including neurons and insulin-producing cells in the pancreas to become functional cells. This finding opens a new avenue for research on therapeutic uses of breast milk-derived stem cells. Recently Dr. Foteini Hassiotou used glowing mice, which were genetically modified to express...
Source: Current Stem Cell Research and Therapy - November 6, 2019 Category: Stem Cells Authors: Ghosh A Tags: Curr Stem Cell Res Ther Source Type: research

Gingiva-derived Mesenchymal Stem Cells and Their Potential Applications in Oral and Maxillofacial Diseases.
CONCLUSION: GMSCs are easily harvestable adult stem cells with outstanding proliferation, differentiation, and immunomodulation characteristics. A growing body of evidence indicates that GMSCs have strong potential use in accelerating wound healing and promoting the regeneration of bone defects, periodontium, oral neoplasms, salivary glands, peri-implantitis, and nerves. Moreover, alginate, polylactic acid, and polycaprolactone can be used as biodegradable scaffolds for GMSC encapsulation. Various growth factors can be applied to the corresponding scaffolds to obtain the desired GMSC differentiation and phenotypes. Three-d...
Source: Current Stem Cell Research and Therapy - November 6, 2019 Category: Stem Cells Authors: Gao X, Cao Z Tags: Curr Stem Cell Res Ther Source Type: research

Phospholipase C γ signaling in bone marrow stem cell and relevant natural compounds therapy.
Phospholipase Cγ signaling in bone marrow stem cell and relevant natural compounds therapy. Curr Stem Cell Res Ther. 2019 Nov 06;: Authors: Liu C, He Y, Xu X, He B Abstract Excessive bone resorption has been recognized as a major role in the development of bone-related diseases such as osteoporosis, rheumatoid arthritis, Paget's disease of bone, and cancer metastasis to bone. Phospholipase Cγ (PLCγ) family members PLCγ1 and PLCγ2 are critical regulators of signaling pathways downstream of growth factor receptors, integrins, and immune complexes and play a crucial role in ...
Source: Current Stem Cell Research and Therapy - November 6, 2019 Category: Stem Cells Authors: Liu C, He Y, Xu X, He B Tags: Curr Stem Cell Res Ther Source Type: research

Recent Approaches for Angiogenesis in Search of Successful Tissue Engineering and Regeneration.
Abstract Angiogenesis plays a central role in human physiology from reproduction and fetal development to wound healing and tissue repair/regeneration. Clinically relevant therapies are needed for promoting angiogenesis in order to supply oxygen and nutrients after transplantation, thus relieving the symptoms of ischemia. Increase in angiogenesis can lead to restoration of damaged tissues, thereby leading the way for successful tissue regeneration. Tissue regeneration is a broad field that has shown the convergence of various interdisciplinary fields, wherein living cells in conjugation with biomaterials have been...
Source: Current Stem Cell Research and Therapy - November 4, 2019 Category: Stem Cells Authors: Reddy LVK, Murugan D, Mullick M, Begum M ET, Sen D Tags: Curr Stem Cell Res Ther Source Type: research

Co-culture and mechanical stimulation on mesenchymal stem cells and chondrocytes for cartilage tissue engineering.
Abstract Defects in articular cartilage injury and the chronic osteoarthritis are very widespread and common, and the ability of injured cartilage to repair itself is limited. Stem cell-based cartilage tissue engineering provides a promising therapeutic option for articular cartilage damage. However, the application of the technique is limited by the number, source, proliferation and differentiation of stem cells. Co-culture of mesenchymal stem cells and chondrocytes is available for cartilage tissue engineering, and mechanical stimulation is an important factor that should not be ignored. A combination of these t...
Source: Current Stem Cell Research and Therapy - October 28, 2019 Category: Stem Cells Authors: Chen Y, Ouyang X, Wu Y, Guo S, Xie Y, Wang G Tags: Curr Stem Cell Res Ther Source Type: research

Stem Cells from Human Exfoliated Deciduous Teeth: A Concise Review.
Abstract Stem cells from human exfoliated deciduous teeth (SHED) originate from the embryonic neural crest as ectodermal mesenchymal stem cells and are isolated from human deciduous teeth.SHED expresses the same cell markers as embryonic stem cells (ESCs), such as OCT4 and NANOG, which make SHED have a significant impact on clinical applications. SHED possess higher rates of proliferation, higher telomerase activity, increased cell population doubling,form sphere-like clusters, and possess immature and multi-differentiation capacity; such high plasticity make SHED is one ofthe most popular source of stem cells for...
Source: Current Stem Cell Research and Therapy - October 18, 2019 Category: Stem Cells Authors: Ko CS, Chen JH, Su WT Tags: Curr Stem Cell Res Ther Source Type: research

Human Pluripotent Stem Cells for Spinal Cord Injury.
Abstract Spinal cord injury (SCI) as a serious public health issue and neurological insult is one of the most causes of long-term disability. To date, a variety of techniques have been widely developed to treat central nervous system injury. Currently, clinical treatments are limited to surgical decompression and pharmacotherapy. Because of their negative effects and inefficiency, novel therapeutic approaches in the management of SCI are required. Improvement and innovation of stem cell-based therapies have allowed a huge potential for biological and future clinical applications. Human pluripotent stem cells (hPSC...
Source: Current Stem Cell Research and Therapy - October 18, 2019 Category: Stem Cells Authors: Forouzesh M, Hosseini M, Farzaneh M, Azarshab M, Anbiyaiee A, Khoshnam SE Tags: Curr Stem Cell Res Ther Source Type: research

The Application of Mesenchymal Stem Cells and Their Exosomes in Chronic Pain Animals and Patients: A Brief Review.
Abstract Chronic pain is a common condition that seriously affects the quality of human life with variable etiology and complicated symptoms; people who suffer from chronic pain may experience anxiety, depression, insomnia, and other harmful emotions. Currently, chronic pain treatments are nonsteroidal anti-inflammatory drugs and opioids; these drugs are demonstrated to be insufficient and cause severe side effects. Therefore, research into new therapeutic strategies for chronic pain is a top priority. In recent years, stem cell transplantation has been demonstrated to be a potent alternative for the treatment of ...
Source: Current Stem Cell Research and Therapy - September 12, 2019 Category: Stem Cells Authors: Ren J, Liu N, Sun N, Zhang K, Yu L Tags: Curr Stem Cell Res Ther Source Type: research

Stem Cell Senescence: The Obstacle of the Treatment of Degenerative Disk Disease.
Abstract Intervertebral disc (IVD) has a pivotal role in the maintenance of flexible motion. IVD degeneration is one of the primary causes of low back pain and disability, which seriously influences patients' health, and increases the family and social economic burden. Recently stem cell therapy has been proven to be more effective on IVD degeneration disease. However, stem cell senescence is the limiting factor in the IVD degeneration treatment. Senescent stem cells have a negative effect on the self-repair on IVD degeneration. In this review, we delineate that the factors such as telomerase shortening, DNA damag...
Source: Current Stem Cell Research and Therapy - September 6, 2019 Category: Stem Cells Authors: Chen Y, Tang L Tags: Curr Stem Cell Res Ther Source Type: research

Effect of the Histone Deacetylases Inhibitors on the Differentiation of Stem Cells in Bone Damage Repairing and Regeneration.
Abstract Tissue damage repairing and regeneration is a research hot topic. Tissue engineering arises at the historic moment which is a defect repair compound composed of seed cells, tissue engineering scaffolds, and inducing factors. Stem cells have a limited growth period in vitro culture, and they have a pattern of replicating ageing, and these disadvantages are limiting the applications of stem cells in basic research and clinical treatment. The enhancement of stem cell differentiation ability is a difficult problem to overcome, and it is possible to enhance the differentiation ability of stem cells through his...
Source: Current Stem Cell Research and Therapy - September 5, 2019 Category: Stem Cells Authors: Zhao Q, Ji K, Wang T, Li G, Lu W, Ji J Tags: Curr Stem Cell Res Ther Source Type: research

New Progress of Adipose-derived Stem Cells in the Therapy of Hypertrophic Scars.
Abstract Burns are a global public health issue of great concern. The formation of scars after burns and physical dysfunction of patients remain major challenges in the treatment of scars. Regenerative medicine based on cell therapy has become a hot topic in this century. Adipose-derived stem cells (ADSCs) play an important role in cell therapy and have become a promising source of regenerative medicine and wound repair transplantation. However, the anti-scarring mechanism of ADSCs is still unclear yet. With the widespread application of ADSCs in medical, we firmly believe that it will bring great benefits to pati...
Source: Current Stem Cell Research and Therapy - September 4, 2019 Category: Stem Cells Authors: He X, Zhang J, Bai X, Shi J, Hu D Tags: Curr Stem Cell Res Ther Source Type: research

Harnessing Stem Cell Potential for the Treatment of Erectile Function with Diabetes Mellitus: From Preclinical/Clinical Perspectives to Penile Tissue Engineering.
CONCLUSION: This review examines the progress and remaining challenges in diabetes-related SC research regarding ED. Moving forward, it is only with a combined effort of basic biology and translational work that the potential of SC-based therapies in diabetes can be realized. PMID: 31456525 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - August 28, 2019 Category: Stem Cells Authors: Gur S, Hellstrom WJG Tags: Curr Stem Cell Res Ther Source Type: research

Human Pluripotent Stem Cells in Neurodegenerative Diseases: Potentials, Advances, and Limitations.
Abstract Neurodegenerative diseases are progressive and uncontrolled gradual loss of motor neurons function or death of neuron cells in the central nervous system (CNS) and the mechanisms underlying their progressive nature remain elusive. There is urgent need to investigate therapeutic strategies and novel treatments for neural regeneration in disorders like Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). Currently, the development and identification of pluripotent stem cells enabling the acquisition of a large number of neural cells ...
Source: Current Stem Cell Research and Therapy - August 23, 2019 Category: Stem Cells Authors: Kolagar TA, Farzaneh M, Nikkar N, Anbiyaiee A, Heydari E, Khoshnam SE Tags: Curr Stem Cell Res Ther Source Type: research

Stem cell transplantation: A promising therapy for spinal cord injury.
Abstract Spinal cord injury (SCI) causes irreversible functional loss of the affected population. The incidence of SCI keeps increasing, resulting in huge burden on the society. The pathogenesis of SCI involves neuron death and exotic reaction, which could impede neuron regeneration. In clinic, the limited regenerative capacity of endogenous cells after SCI is a major problem. Recent studies have demonstrated that a variety of stem cells such as induced pluripotent stem cells (iPSCs), embryonic stem cells (ESCs), mesenchymal stem cells (MSCs) and neural progenitor cells (NPCs) /neural stem cells (NSCs) have therap...
Source: Current Stem Cell Research and Therapy - August 23, 2019 Category: Stem Cells Authors: Gong Z, Xia K, Xu A, Yu C, Wang C, Zhu J, Huang X, Chen Q, Li F, Liang C Tags: Curr Stem Cell Res Ther Source Type: research

Effects of hypoxia on differentiation of mesenchymal stem cells.
Abstract Mesenchymal stem cells (MSCs) are distributed in many parts of the human body, including the bone marrow, placenta, umbilical cord, fat, and nasal mucosa. One of the unique features of MSCs is their multidirectional differentiation potential, including the ability to undergo osteogenesis, adipogenesis, and chondrogenesis, and to produce neurons, endothelial cells, Schwann cells, medullary nucleus cells, cardiomyocytes, and alveolar epithelial cells. MSCs have thus become a hot research topic in recent years. Numerous studies have investigated the differentiation of MSCs into various types of cells in vitr...
Source: Current Stem Cell Research and Therapy - August 23, 2019 Category: Stem Cells Authors: Chen W, Zhuo Y, Duan D, Lu M Tags: Curr Stem Cell Res Ther Source Type: research

Cancer Stem Cells in Solid Tumors.
hez E Abstract PMID: 31309875 [PubMed - in process] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - July 18, 2019 Category: Stem Cells Authors: Ortiz-Sánchez E Tags: Curr Stem Cell Res Ther Source Type: research

Overview of molecular mechanisms involved in herbal compounds for inhibiting osteoclastogenesis from macrophage linage RAW264.7.
Abstract Differentiation from RAW264.7 cells to osteoclasts rely on many signaling pathways, such as NF-κB, MAPK, Akt and others. However, the specific underlying mechanisms are not clear. Recently, much works have focused on the inhibitory effects of plant derived compounds in the differentiation from RAW264.7 to osteoclasts. However, the specific mechanisms remain unclear. In this paper, we summarize a lot of plant derived compounds which exert blocking effect on the progression of differentiation via signaling pathways. PMID: 31269885 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - July 3, 2019 Category: Stem Cells Authors: He G, Ma R Tags: Curr Stem Cell Res Ther Source Type: research

Puerarin for OVX-induced postmenopausal osteoporosis in murine model: systematic review and meta-analysis.
Abstract AIMS/BACKGROUND: Ovariectomy (OVX)-induced murine model are widely used for post-menopausal osteoporosis study. Our current study was conducted to systematically review and critically assess the bone mass improved effect of puerarin for treating OVX-induced postmenopausal osteoporosis in murine model. METHODS: Literatures from PUBMED, EMBASE, and CNKI were searched from their inception date to January 9th, 2019. Two reviewers independently selected animal studies that evaluated the bone mass improved effect of puerarin compared with control in OVX-induced rats. Extracted data were analyzed by RevMan ...
Source: Current Stem Cell Research and Therapy - July 3, 2019 Category: Stem Cells Authors: Yang X, Zheng H, Liu Y, Hao D, He B, Kong L Tags: Curr Stem Cell Res Ther Source Type: research

Stem cells-based and molecular-based approaches in regenerative dentistry: A topical review.
CONCLUSIONS: This topical review has been focused on the main, the most promising and the most innovative strategies for achieving the regeneration of dental pulp or dental tissues. The main and surprising "take-home message" is related to the great interest towards the dental-derived stem cells, characterized by a high angiogenic and neurogenic commitment. Future challenges will be focused on the development of biological-friendly regenerative strategies: the new approaches should overcome the current biological limitations, to promote the combined cellular and molecular-based treatments, able to ensure a predic...
Source: Current Stem Cell Research and Therapy - June 26, 2019 Category: Stem Cells Authors: Tatullo M, Codispoti B, Makeeva I, Scacco S, Cocco T Tags: Curr Stem Cell Res Ther Source Type: research

Epigenetic Regulator Signatures in Regenerative Capacity.
CONCLUSION: An improved understanding of the regeneration process and the epigenetic regulation thereof through the study of regeneration in highly regenerative species will help in the field of regenerative medicine in future. PMID: 31244431 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - June 18, 2019 Category: Stem Cells Authors: Albogami S Tags: Curr Stem Cell Res Ther Source Type: research

Stem cells in rotator cuff injuries and reconstructions: A systematic review and meta-analysis.
CONCLUSIONS: This meta-analysis confirms that stem cell improved the rehabilitation of the rotator cuff disorders. However, larger-scale studies are needed to further support these findings. PMID: 31244430 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - June 17, 2019 Category: Stem Cells Authors: Liu F, Meng Q, Yin H, Yan Z Tags: Curr Stem Cell Res Ther Source Type: research

Coreceptor-Based Hematopoietic Stem Cell Gene Therapy for HIV Disease.
Abstract Combination antiretroviral therapy (cART) has significantly reduced the mortality rate and morbidity, and has increased life expectancy of human immunodeficiency virus (HIV) infected patients. However, current cART is incapable of eradicating viruses from the human body, and HIV remains one of the most notorious viruses mankind has ever faced. HIV-1 enters target cells through the binding of gp120 viral protein to a CD4 receptor and then to a coreceptor, C-C chemokine receptor 5 (CCR5) or C-X-C chemokine receptor type 4 (CXCR4). Individuals homozygous for a 32-bp deletion in the CCR5 allele, CCR5Δ32...
Source: Current Stem Cell Research and Therapy - May 22, 2019 Category: Stem Cells Authors: Hu JT, Feng YW, Ma P, Lai Y Tags: Curr Stem Cell Res Ther Source Type: research