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Unlocking the Potential of Induced Pluripotent Stem Cells in Revolutionizing Cancer Therapy
This article highlights the potential of iPSC- based NK cells and dendritic cells for immunotherapy and delves into the role of iPSC-based mesenchymal cells in targeted therapy. The potential of iPSC-derived organoids as a vital tool for disease modeling and drug discovery has been showcased, and the importance of iPSC-based cancer vaccines is also emphasized. The ongoing clinical trials of iPSC-based cancer treatment have also been highlighted. Though much work remains to be done to implicate these iPSC-based therapeutic options from research labs to clinics and hospitals, ongoing studies and clinical/translational follow...
Source: Current Stem Cell Research and Therapy - April 17, 2024 Category: Stem Cells Authors: Amrita Mondal Ankita Talukdar Rizwanul Haque Source Type: research

Outcomes of Patients with Heavily Pretreated Relapsed/Refractory Multiple Myeloma Receiving Salvage Cytotoxic Therapy with Supportive Stem Cell Boost
CONCLUSION: This data allow clinicians to appropriately implement and inform patients of the therapeutic uses and clinical outcomes of stem cell boost in patients with multiply relapsed/refractory MM.PMID:38584546 | DOI:10.2174/011574888X287532240325041249 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - April 8, 2024 Category: Stem Cells Authors: Ayrton Bangolo Samir Oza Ronit Slotky Aimee Chappell David Siegel Harsh Parmar Noa Biran David H Vesole Pooja Phull Source Type: research

The Renoprotective and Anti-Inflammatory Effects of Human Urine-Derived Stem Cells on Acute Kidney Injury Animals
CONCLUSION: In summary, our results highlighted the effectiveness of USCs in protecting from PTC injury and impeding macrophage polarization, as well as the secretion of pro-inflammatory interleukins, suggesting the potential of USCs as a novel cell therapy in AKI.PMID:38571344 | DOI:10.2174/011574888X296559240326063705 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - April 4, 2024 Category: Stem Cells Authors: Yuanyuan Kuang Chenyu Fan Xiaojun Long Jiajia Zheng Yunsi Zeng Yuhui Wei Jiasheng Zhang Shuangjin Yu Tong Chen Hehuan Ruan Yi Wang Ning Na Yiming Zhou Jiang Qiu Source Type: research

Construction of a Cancer Stem Cell related Histone Acetylation Regulatory Genes Prognostic Model for Hepatocellular Carcinoma via Bioinformatics Analysis: Implications for Tumor Chemotherapy and Immunity
CONCLUSION: This study constructed a mRNAsi and HAGs-related prognostic model, which has implications for potential immunotherapy and drug treatment of LIHC.PMID:38561604 | DOI:10.2174/011574888X305642240327041753 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - April 1, 2024 Category: Stem Cells Authors: Qian Dai Jie Zhu Jing Yang Chun-Yan Zhang Wen-Jing Yang Bai-Shen Pan Xin-Rong Yang Wei Guo Bei-Li Wang Source Type: research

Comparative Outcomes of Intravenous, Intranasal, and Intracerebroventricular Transplantation of Human Neural Stem Cells in Mice Model of Ischemic Stroke
CONCLUSION: IV and IN delivery is suitable for repeated administration of hNSCs to achieve improved prognosis. Comparatively, ICV transplantation provides long-term efficacy at lower doses and fewer administration times.PMID:38529606 | DOI:10.2174/011574888X290104240320041613 (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - March 26, 2024 Category: Stem Cells Authors: Mengze Zhang Yaying Song Chong Xie Yangtai Guan Source Type: research