Human Adipose-Derived Stem Cells with great Therapeutic Potential.
Abstract The potential use of stem cell-based therapies for the repair and regeneration of various tissues and organs offers a paradigm shift in regenerative medicine. The use of either embryonic stem cells (ESC) or induced pluripotent stem cells (iPSC) in clinical situations is limited because of regulations and ethical considerations even though these cells are theoretically highly beneficial. While clinically, adipose-derived stem cells (ADSCs) are one of the most widely used types of stem cells used more than five years in clinically setting. It has many advantages including; yields a high number of ADSCs per ...
Source: Current Stem Cell Research and Therapy - April 11, 2019 Category: Stem Cells Authors: Sheykhhasan M, Wong JKL, Seifalian AM Tags: Curr Stem Cell Res Ther Source Type: research

Exploring and Exploiting Tissue Engineering Through the Design of Multifunctional Therapeutic Systems.
This article presents a special issue of "Current Stem Cell Research & Therapy" devoted to exploring and exploiting tissue engineering through the design of multifunctional therapeutic systems. This lead article draws from twelve contributed articles to discuss the most recent advancements in this emerging field. The common theme in the contributed articles is the emerging therapeutic strategies, and a special appeal is made for collaboration between engineers and biologists for the development of multifunctional therapeutic systems for tissue engineering and regenerative medicine. PMID: 30957721 [PubMed...
Source: Current Stem Cell Research and Therapy - April 9, 2019 Category: Stem Cells Authors: Mozafari M Tags: Curr Stem Cell Res Ther Source Type: research

Overview of cellular mechanisms and signaling pathways of Piceatannol.
Abstract Stilbenoids are a group of naturally occurring phenolic compounds found in various plant species. They share a common backbone structure known as stilbene. However, differs in the nature and position of substituents have make it possible to produce many derivatives. Piceatannol [PT], a hydroxylated derivative from resveratrol, exerts various biological activities ranging from cancer prevention, cardio-protection, neuro-protection, anti-diabetic, depigmentation and so on. Although positive results were obtained in most cell culture and animal studies, the relevant cellular and molecular mechanisms cytokine...
Source: Current Stem Cell Research and Therapy - April 1, 2019 Category: Stem Cells Authors: Cao Y, Smith W, Yan L, Kong L Tags: Curr Stem Cell Res Ther Source Type: research

The application of neural stem/progenitor cells for regenerative therapy of spinal cord injury.
Abstract Spinal cord injury (SCI) is a devastating event, and there are still no effective therapies currently available. Neural stem cells (NSCs) have gained increasing attention as promising regenerative therapy of SCI. NSCs based therapies of various neural diseases in animal models and clinical trials have been widely investigated. In this review we aim to summarize the development and recent progress in the application of NSCs in cell transplantation therapy for SCI. After brief introduction on sequential genetic steps regulating spinal cord development in vivo, we describe current experimental approaches for...
Source: Current Stem Cell Research and Therapy - March 28, 2019 Category: Stem Cells Authors: Yu C, Xia K, Gong Z, Ying L, Shu J, Zhang F, Chen Q, Li F, Liang C Tags: Curr Stem Cell Res Ther Source Type: research

Current status of used protocols for mesenchymal stem cell differentiation: a focus on insulin producing, osteoblast-like and neural cells.
Abstract Mesenchymal stem cells (MSCs) are attracted a great deal of interest in the field of regenerative medicine because of their differentiation ability into mesodermal derivatives and even other germ layers. The main requirement for better differentiation of MSCs into desired cell lineage is relied on pure population of these cells. During the past years, significant progresses have been developed for identification of MSCs by introducing new markers or different combination of markers. Currently, direct in vitro differentiation protocols using standard media supplemented with specific growth factors generati...
Source: Current Stem Cell Research and Therapy - March 17, 2019 Category: Stem Cells Authors: Rajabi H, Hosseini V, Rahimzadeh S, Seyfizadeh N, Aslani S, Abhari A Tags: Curr Stem Cell Res Ther Source Type: research

The roles of different stem cells on premature ovarian failure.
Abstract Premature ovarian failure (POF) is characterized by amenorrhea, hypergonadotropism and hypoestrogenism before the age of 40, which affects 1% of women in the general population. POF is complex and heterogeneous due to the pathogenetic mechanisms. And it is one of the significant causes for female infertility. Although many treatments are available for POF, the therapies are lower efficient and cause many side effects. Therefore, it is still urgent to found the effective therapeutics for POF. Stem cells have self-renewal and regeneration potential, and are effective for the treatment of ovarian failure and...
Source: Current Stem Cell Research and Therapy - March 14, 2019 Category: Stem Cells Authors: Zhang C Tags: Curr Stem Cell Res Ther Source Type: research

Suppression of TGF- β and ERK signaling pathways as a new strategy to provide rodent and non-rodent pluripotent stem cells.
Suppression of TGF-β and ERK signaling pathways as a new strategy to provide rodent and non-rodent pluripotent stem cells. Curr Stem Cell Res Ther. 2019 Mar 13;: Authors: Farzaneh M, Derakhshan Z, Hallajzadeh J, Sarani NH, Nejabatdoust A, Khoshnam SE Abstract Stem cells are unspecialized cells and excellent model in developmental biology and a promising approach to the treatment of disease and injury. In the last 30 years, pluripotent embryonic stem (ES) cells were established from murine and primate sources, and display indefinite replicative potential and the ability to differentiate to all thr...
Source: Current Stem Cell Research and Therapy - March 13, 2019 Category: Stem Cells Authors: Farzaneh M, Derakhshan Z, Hallajzadeh J, Sarani NH, Nejabatdoust A, Khoshnam SE Tags: Curr Stem Cell Res Ther Source Type: research

Effects of Extracellular Vesicles Derived from Mesenchymal Stem/stromal Cells on Liver Diseases.
Abstract Therapeutic effects of mesenchymal stem/stromal cells (MSCs) transplantation have been observed in various disease models. However, it is thought that MSCs-mediated effects largely depend on the paracrine manner of secreting cytokines, growth factors, and extracellular vesicles (EVs). Similarly, MSCs-derived EVs also showed therapeutic benefits in various liver diseases through alleviating fibrosis, improving regeneration of hepatocytes, and regulating immune activity. This review provides an overview of the MSCs, their EVs, and their therapeutic potential in treating various liver diseases including live...
Source: Current Stem Cell Research and Therapy - March 8, 2019 Category: Stem Cells Authors: Zheng W, Yang Y, Sequeira RC, Bishop CE, Atala A, Gu Z, Zhao W Tags: Curr Stem Cell Res Ther Source Type: research

The Prognostic Value of Circulating Tumor Cells in Primary Breast Cancer Prior to any Systematic Therapy: A Systematic Review.
CONCLUSION: Results of this meta-analysis allude CTCs as potent prognostic marker in primary breast cancers prior to any systemic therapy especially when it is studied via CellSearch ® administration, considering that the more the CTCs, the greater the death and relapse rates. PMID: 30843493 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - March 5, 2019 Category: Stem Cells Authors: Mansouri S, Hesari PM, Naghavi-Al-Hosseini F, Majidzadeh-A K, Farahmand L Tags: Curr Stem Cell Res Ther Source Type: research

The study of cellular mechanism of triptolide in the treatment of cancer, bone loss and cardiovascular disease and triptolide's toxicity.
Abstract Triptolide (TPL), the active component of Tripterygium wilfordii Hook F (Twhf) has been used to treat cancer and bone loss conditions for over two hundred years in traditional Chinese medicine (TCM). In this paper, we reviewed the specific molecular mechanisms in the treatment of cancer, bone loss and cardiovascular disease. In addition, we analyze the toxicity of TPL and collect some optimized derivatives extracted from TPL. Although positive results were obtained in most cell culture and animal studies, further studies are needed to substantiate the beneficial effects of TPL. PMID: 30834841 [PubMed...
Source: Current Stem Cell Research and Therapy - March 1, 2019 Category: Stem Cells Authors: Wang Y, Wang B, Yang X Tags: Curr Stem Cell Res Ther Source Type: research

Harnessing stem cells and neurotrophic factors with novel technologies in the treatment of Parkinson's disease.
Abstract Parkinson's disease (PD) is characterized by loss of dopaminergic neurons, oxidative stress and neuroinflammation. The classical therapeutic approach with L-DOPA is not able to control motor symptoms in the long term, thus new disease-modifying or neuroprotective treatments are urgently required in order to match such yet unmet clinical need. Success in cell-based therapy has been accomplished at a clinical level with human fetal mesencephalic tissue, but ethical issues and shortage of organs clearly underline the need for novel sources of dopaminergic neurons. Mesenchymal stem cells (MSCs) can be obtaine...
Source: Current Stem Cell Research and Therapy - March 1, 2019 Category: Stem Cells Authors: Conese M, Cassano R, Gavini E, Trapani G, Rassu G, Sanna E, Di Gioia S, Trapani A Tags: Curr Stem Cell Res Ther Source Type: research

Emerging Role of Mesenchymal Stem Cell-derived Exosomes in Regenerative Medicine.
CONCLUSION: This review summarizes the most recent knowledge of therapeutic potential of MSC-Ex in liver, heart, kidney, bone, brain diseases and cancer, as well as their associated challenges and opportunities. PMID: 30819086 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - February 27, 2019 Category: Stem Cells Authors: Zhao T, Sun F, Liu J, Ding T, She J, Mao F, Xu W, Qian H, Yan Y Tags: Curr Stem Cell Res Ther Source Type: research

Approaches to Targeting Cancer Stem Cells in Solid Tumors.
Abstract CSCs are a population of self-renewing and tumor repopulating cells that have been observed in hematologic and solid tumors and their presence contributes to the development of drug resistance. The failure to eliminate CSCs with conventional therapy is one of major obstacles in the successful treatment of cancer. Several mechanisms have been described to contribute to CSCs chemoresistance properties that include the adoption of drug-efflux pumps, drug detoxification pathways, changes in metabolism, improved DNA repair mechanisms, and deregulated survival and pro-apoptotic pathways. Thus, CSCs are therefor...
Source: Current Stem Cell Research and Therapy - February 22, 2019 Category: Stem Cells Authors: Caldas-Lopes E, Gomez-Arteaga A, Guzman ML Tags: Curr Stem Cell Res Ther Source Type: research

Therapeutic potential of amniotic fluid derived mesenchymal stem cells based on their differentiation capacity and immunomodulatory properties.
CONCLUSION: Considering the fact that amniotic fluid is obtained through routine prenatal diagnosis, with minimal invasive procedure and without ethical concerns, AF-MSCs represents a valuable source for cell-based therapy of organ-specific or systemic degenerative and inflammatory diseases. PMID: 30806325 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - February 22, 2019 Category: Stem Cells Authors: Harrell CR, Gazdic M, Fellabaum C, Jovicic N, Djonov V, Arsenijevic N, Volarevic V Tags: Curr Stem Cell Res Ther Source Type: research

What Will Become of the Taxpayer Investment in Public Cord Blood Stem Cell Banking?
Abstract Cord blood (CB) is a unique and readily available source of hematopoietic stem cells for transplantation. CB also contains other types of stem cells, including endothelial stem cells and mesenchymal stem cells, that may prove useful in non-traditional clinical uses. Genetic and molecular analyses have demonstrated that CB stem cells lie somewhere between mature stem cells like those found in bone marrow (BM), and fetal stem cells. After 25 years of clinical experience CB is now used in the same fashion as BM for all typical malignant and genetic diseases treated by bone marrow transplant. Due to the estab...
Source: Current Stem Cell Research and Therapy - February 22, 2019 Category: Stem Cells Authors: Harris DT, Israel S Tags: Curr Stem Cell Res Ther Source Type: research

Therapeutic Potential of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood.
Abstract Endothelial progenitor cells (EPCs) are implicated in mutiple biologic processes such as vascular homeostasis, neovascularization and tissue regeneration, and tumor angiogenesis. A subtype of EPCs is referred to as endothelial colony-forming cells (ECFCs), which display robust clonal proliferative potential and can form durable and functional blood vessels in animal models. In this review, we provide a brief overview of EPCs' characteristics, classification and origins, a summary of the progress in preclinical studies as regard to the therapeutic potential of human umbilical cord blood derived ECFCs (CB-E...
Source: Current Stem Cell Research and Therapy - February 14, 2019 Category: Stem Cells Authors: Jia J, Ma B, Wang S, Feng L Tags: Curr Stem Cell Res Ther Source Type: research

Macrophages on Bone Homeostasis.
Abstract Aberrant or prolonged immune responding has been proved involved in bone homeostasis. As a component of the innate immune system, macrophages play a critical role in bone homeostasis. Conventionally, according to response to various panel of stimuli, macrophages can be plastically classified as two major phenotypes: M1 and M2. M1 macrophages are generally pro-inflammatory, whereas M2 are anti-inflammatory. Although studies demonstrated both M1 and M2 phenotypes have been implicated in various inflammatory bone diseases, their direct role in bone homeostasis remains exploring. Thus, in this review we brief...
Source: Current Stem Cell Research and Therapy - February 14, 2019 Category: Stem Cells Authors: Kong L, Wang Y, Smith W, Hao D Tags: Curr Stem Cell Res Ther Source Type: research

Endometrial Regeneration in Asherman's Syndrome: Clinical and Translational evidence of Stem Cell Therapies.
Abstract Asherman's Syndrome or Intrauterine adhesions is an acquired uterine condition where fibrous scarring forms within the uterine cavity, resulting in reduced menstrual flow, pelvic pain and infertility. Until recently, the molecular mechanisms leading to the formation of fibrosis were poorly understood, and the treatment of Asherman's syndrome has largely focused on hysteroscopic resection of adhesions, hormonal therapy, and physical barriers. Numerous studies have begun exploring the molecular mechanisms behind the fibrotic process underlying Asherman's Syndrome as well as the role of stem cells in the reg...
Source: Current Stem Cell Research and Therapy - February 12, 2019 Category: Stem Cells Authors: Hou X, Liu Y, Streuli I, Dallenback P, Dubuisson J, Ansaldi Y, Pluchino N Tags: Curr Stem Cell Res Ther Source Type: research

Preface.
Abstract PMID: 30684320 [PubMed - in process] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - January 28, 2019 Category: Stem Cells Authors: Yoo JJ Tags: Curr Stem Cell Res Ther Source Type: research

Towards Standardized Stem Cell Therapy in Type 2 Diabetes Mellitus: A Systematic Review.
Abstract PMID: 30684321 [PubMed - in process] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - January 28, 2019 Category: Stem Cells Authors: Sheykhhasan M Tags: Curr Stem Cell Res Ther Source Type: research

A Consideration of the Non-Pregnant Human Uterus as a Stem Cell Source for Medical Therapy.
Abstract PMID: 30684322 [PubMed - in process] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - January 28, 2019 Category: Stem Cells Authors: Eisenberg CA, Eisenberg LM Tags: Curr Stem Cell Res Ther Source Type: research

The expression and functional roles of miRNAs in embryonic and lineage-specific stem cells.
Abstract The discovery of small non-coding RNAs opened an interesting era in cellular and molecular biology. To date, miRNAs are the best recognized non-coding RNAs for maintenance and differentiation of pluripotent stem cells including embryonic stem cells (ES), induced pluripotent stem cells (iPSC), and cancer stem cells. ES cells are defined by their ability to self-renew, teratoma formation, and to produce numerous types of differentiated cells. Dual capacity of ES cells for self-renewal and differentiation is controlled by specific interaction with the neighboring cells and intrinsic signaling pathways from t...
Source: Current Stem Cell Research and Therapy - January 23, 2019 Category: Stem Cells Authors: Farzaneh M, Alishahi M, Derakhshan Z, Sarani NH, Attari F, Khoshnam SE Tags: Curr Stem Cell Res Ther Source Type: research

Bone Marrow Niches for Skeletal Progenitor Cells and their Inhabitants in Health and Disease.
Abstract The bone marrow hosts skeletal progenitor cells which have most widely been referred to as mesenchymal stem or stromal cells (MSCs), a heterogeneous population of adult stem cells possessing potential for self-renewal and multilineage differentiation. A consensus agreement on minimal criteria has been suggested to define MSCs in vitro, including adhesion to plastic, expression of typical surface markers and the ability to differentiate towards the adipogenic, osteogenic and chondrogenic lineages but they are critically discussed since the differentiation capability of cells could not always be confirmed b...
Source: Current Stem Cell Research and Therapy - January 23, 2019 Category: Stem Cells Authors: Herrmann M, Jakob F Tags: Curr Stem Cell Res Ther Source Type: research

The Role of Exosomes in Diseases Related to Infertility.
This article reviews the latest progress of researches on exosomes in diseases lead to infertility. PMID: 30674267 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - January 23, 2019 Category: Stem Cells Authors: Huang J, Gao Y Tags: Curr Stem Cell Res Ther Source Type: research

Bioreactors Design, Types, Influencing Factors and Potential Application in Dentistry. A Literature Review.
CONCLUSIONS: Bioreactors provide a sterile simulated environment to support cellular differentiation for oro-dental regenerative applications. Also bioreactors like, customize bioreactors for cyclic loading, biofilm reactors (CDC & drip-flow), and micro-bioreactor, can assess biological responses of dental biomaterials by simultaneously supporting cellular or biofilm growth and application of cyclic stresses. PMID: 30636614 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - January 10, 2019 Category: Stem Cells Authors: Malhotra N Tags: Curr Stem Cell Res Ther Source Type: research

Inflammatory cytokines and biodegradable scaffolds in dental mesenchymal stem cells priming.
Abstract Mesenchymal stem cells (MSC) are multipotent stem cells with wide-ranging clinical applications due to their ability to regenerate tissue from mesenchymal origin and their capability of suppressing immune responses, thus reducing the likelihood of graft versus host disease after transplantation. MSCs can be isolated from a variety of sources including bone marrow, adipose tissue, umbilical cord blood, and immature teeth. Dental stem cells (DSC) possess progenitor and immunomodulatory abilities as the other MSC types and because they can be easily isolated, are considered as attractive therapeutic agents i...
Source: Current Stem Cell Research and Therapy - January 3, 2019 Category: Stem Cells Authors: Kanjevac T, Gustafson C, Ivanovska A, Ravanetti F, Cacchioli A, Bosnakovski D Tags: Curr Stem Cell Res Ther Source Type: research

The effect of physical cues on the stem cell differentiation.
Abstract Development of multicellular organisms is a very complex and organized process during which cells respond to various factors and features in extracellular environments. It has been demonstrated that during embryonic evolvement, under certain physiological or experimental conditions, unspecialized cells or stem cells can be induced to become tissue or organ-specific cells with special functions. Considering the importance of physical cues in stem cell fate, the present study reviews the role of physical factors in stem cells differentiation and discusses the molecular mechanisms associated with these facto...
Source: Current Stem Cell Research and Therapy - December 27, 2018 Category: Stem Cells Authors: Moghaddam MM, Bonakdar S, Shariatpanahi MR, Shokrgozar MA, Faghihi S Tags: Curr Stem Cell Res Ther Source Type: research

Mini-review:Functions and Action Mechanisms of PQQ in Osteoporosis and Neuro Injury.
This article mainly discusses the derivatives, distribution of PQQ, in vitro models of osteoporosis and neuro injury, and the research progress of its mechanism of action. It provides new ideas in the study of osteoporosis and neuro injury. PMID: 30526470 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - December 10, 2018 Category: Stem Cells Authors: Wen H, He Y, Zhang K, Yang X, Hao D, He B Tags: Curr Stem Cell Res Ther Source Type: research

Stimulators and relevant signaling cascades for NFATc1 in bone cell homeostasis: friend or foe?
Abstract Bone homeostasis is strictly regulated by balanced activity of bone-forming osteoblasts and bone-resorbing osteoclasts.Disruption of the balance of activity between osteoblasts and osteoclasts leads to various metabolic bone diseases.Osteoclasts are cells of hematopoietic origin that they are large, multinucleated cells formed by the fusion of precursor cells of monocyte/macrophage lineage,they are unique cells that degrade the bone matrix. activation of transcription factors nuclear factor-activated T cells c1 (NFATc1) is required for sufficient osteoclast differentiation and it plays the role of a maste...
Source: Current Stem Cell Research and Therapy - December 5, 2018 Category: Stem Cells Authors: Zhang Z, Wen H, Yang X, Zhang K, He B, Zhang X, Kong L Tags: Curr Stem Cell Res Ther Source Type: research

Biomaterials and gene therapy: a smart combination for MSC musculoskeletal engineering.
cute; Abstract Musculoskeletal pathologies, especially those affecting bones and joints, remain a challenge for regenerative medicine. The main difficulties affecting bone tissue engineering are the size of the defects, the need for blood vessels and the synthesis of appropriate matrix elements in the engineered tissue. Indeed, the cartilage is an avascular tissue and consequently has limited regenerative abilities. Thanks to their self-renewal, plasticity and immunomodulatory properties, mesenchymal stem cells (MSCs) became a central player in tissue engineering, and have already been shown to be able to differen...
Source: Current Stem Cell Research and Therapy - December 5, 2018 Category: Stem Cells Authors: Mesure B, Menu P, Venkatesan JK, Cucchiarini M, Velot É Tags: Curr Stem Cell Res Ther Source Type: research

Stem cells and endometrial regeneration: from basic research to clinical trial.
ing L Abstract Monthly changes in the endometrial cycle indicate the presence of endometrial stem cells. In recent years, various stem cells that exist in the endometrium have been identified and characterized. Additionally, many studies have shown that bone marrow mesenchymal stem cells (BM-MSCs) provide an alternative source for regenerating the endometrium and repairing endometrial injury. This review discusses the origin of endometrial stem cells, the characteristics and main biomarkers among five types of putative endometrial stem cells, applications of endometrium-derived stem cells and menstrual blood-deriv...
Source: Current Stem Cell Research and Therapy - December 5, 2018 Category: Stem Cells Authors: Zhu X, Péault B, Yan G, Sun H, Hu Y, Ding L Tags: Curr Stem Cell Res Ther Source Type: research

Immunomodulatory properties of mesenchymal stromal cells: still unresolved "Yin and Yang".
Immunomodulatory properties of mesenchymal stromal cells: still unresolved "Yin and Yang". Curr Stem Cell Res Ther. 2018 Dec 04;: Authors: Poggi A, Zocchi MR Abstract Mesenchymal stromal cells (MSC) are mesodermal elements characterized by the ability to differentiate into several types of cells present mainly in connective tissues. They play a key function in tissue homeostasis and repair. Furthermore, they exert a strong effect on both innate and adaptive immune response. The main current of thought considers MSC as strong inhibitors of the immune system. Indeed, the first description of M...
Source: Current Stem Cell Research and Therapy - December 4, 2018 Category: Stem Cells Authors: Poggi A, Zocchi MR Tags: Curr Stem Cell Res Ther Source Type: research

Long Noncoding RNA :Function and Mechanism on Differentiation of Mesenchymal Stem Cells and Embryonic Stem Cells.
CONCLUSION: LncRNAs are involved in the differentiation process of mesenchymal stem cells and embryonic stem cells, and they could become promising indicator, biomarker and therapeutic targets in the physiologic and pathologic process. However, the mechanisms of the role of lncRNAs still require further investigation. PMID: 30479219 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - November 27, 2018 Category: Stem Cells Authors: Zhu J, Wang Y, Yu W, Xia K, Huang Y, Wang J, Liu B, Li F, Liang C, Tao H Tags: Curr Stem Cell Res Ther Source Type: research

Biological effects study of Myricitrin and relevant molecular mechanisms.
Abstract In humans, oxidative stress is thought to be involved in the development of Parkinson' s disease, Alzheimer's disease, atherosclerosis, heart failure, myocardial infarction, depression. Myricitrin, a botanical flavone, is abundantly distributed in the root bark of Myrica cerifera, Myrica esculenta, Ampelopsis grossedentata, Nymphaea lotus, Chrysobalanus icaco, and other plants. Considering the abundance of its natural sources, myricitrin is relatively easy to extract and purify. Myricitrin reportedly possesses effective anti-oxidative, anti-inflammatory, and anti-nociceptive activities, and can protect a ...
Source: Current Stem Cell Research and Therapy - November 25, 2018 Category: Stem Cells Authors: Zhang X, Zhang K, Wang Y, Ma R Tags: Curr Stem Cell Res Ther Source Type: research

Application of Cell Therapy for Anti-Aging Facial Skin.
Abstract The human skin undergoes the complex process of aging which is prompted by the interplay of intrinsic mechanisms and extrinsic influences. Aging is unavoidable but can be somewhat delayed. Numerous approaches have been developed to slow down or improve on facial skin aging process as it is of interest to stake holders in the beauty and fashion world as well as to plastic surgeons. Adipose-derived stem cell [ADSC] and mesenchymal stem cell [MSC] as potential anti-ageing agents to some extent has provided a promising and effective alternative in managing skin and facial skin ageing. Furthermore, bone marrow...
Source: Current Stem Cell Research and Therapy - November 12, 2018 Category: Stem Cells Authors: Zarei F, Abbaszadeh A Tags: Curr Stem Cell Res Ther Source Type: research

Stem cell-mediated angiogenesis in tissue engineering constructs.
Abstract Angiogenesis has always been a concern in the field of tissue engineering. Poor vascularization of engineered constructs is a problem for clinical success of these structures. Among the various methods employed to induce angiogenesis, stem cells provide a promising tool for future. The present review aims to present the application of stem cells in the induction of angiogenesis. Additionally, it summarizes recent advancements in stem cell-mediated angiogenesis of different tissue engineering constructs. PMID: 30394215 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - November 5, 2018 Category: Stem Cells Authors: Kiaie N, Aghdam RM, Tafti SHA, Gorabi AM Tags: Curr Stem Cell Res Ther Source Type: research

Transplantation of Adipose-derived Cells for Periodontal Regeneration: A Systematic Review.
Abstract This systematic review evaluated the transplantation of cells derived from adipose tissue for applications in dentistry. SCOPUS, PUBMED and LILACS databases were searched for in vitro studies and pre-clinical animal model studies using the keywords "ADIPOSE", "CELLS", and "PERIODONTAL", with the Boolean operator "AND". A total of 160 titles and abstracts were identified, and 29 publications met the inclusion criteria, 14 in vitro and 15 in vivo studies. In vitro studies demonstrated that adipose-derived cells stimulate neovascularization, have osteogenic and odontog...
Source: Current Stem Cell Research and Therapy - November 5, 2018 Category: Stem Cells Authors: Dziedzic DSM, Mogharbel BF, Ferreira PE, Irioda AC, de Carvalho KAT Tags: Curr Stem Cell Res Ther Source Type: research

New advances in stem cell therapy for osteonecrosis of the femoral head.
This article summarizes the current advances in stem cell therapy for ONFH, as well as the problems and challenges, which may provide reference for further research. PMID: 30360727 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - October 25, 2018 Category: Stem Cells Authors: Zhou W, Qu M, Lv Y, Zhu J Tags: Curr Stem Cell Res Ther Source Type: research

Molecular Docking In Formulation And Development.
This article reviews the studies evaluating the effects of the nanofibrous scaffold and stem cells in diabetes treatment. Furthermore, various studies have pointed out that the use of biomaterials, processed by the electrospinning technique, has gained considerable interest for TE applications. PMID: 30338744 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - October 18, 2018 Category: Stem Cells Authors: Hoveizi E, Tavakol S, Shirian S, Sanamiri K Tags: Curr Stem Cell Res Ther Source Type: research

The Potential Roles of Tendon Stem/Progenitor Cells in Tendon Ageing.
Abstract Ageing is a key dangerous factor for the occurrence and severity of tendon injury, but the exact cognition of the relationship is elusive at present. More previous studies suggest age-related changes occur at tendon mechanical properties, structure and composition, but the pathological alternations may be overlooked, which might be causes for the structure and function variations, and even speed up the progress of age-related disorders. Recently, the presence of tendon stem/progenitor cells (TSPCs) would provide new insights for pathogenesis of tendon ageing. In this review, the tendon mechanical properti...
Source: Current Stem Cell Research and Therapy - October 17, 2018 Category: Stem Cells Authors: Li Y, Dai G, Shi L, Lin Y, Chen M, Li G, Rui Y Tags: Curr Stem Cell Res Ther Source Type: research

Integrin α6 (CD49f), the microenvironment and cancer stem cells.
Integrin α6 (CD49f), the microenvironment and cancer stem cells. Curr Stem Cell Res Ther. 2018 Oct 02;: Authors: Bigoni-Ordonez GD, Czarnowski D, Parsons T, Madlambayan GJ, Villa-Diaz LG Abstract Cancer is a highly prevalent and potentially terminal disease that affects millions of individuals worldwide. Here, we review the literature exploring the intricacies of stem cells bearing tumorigenic characteristics and collect evidence demonstrating the importance of integrin α6 (ITGA6, also known as CD49f) in cancer stem cell (CSC) activity. ITGA6 is commonly used to identify CSC population...
Source: Current Stem Cell Research and Therapy - October 2, 2018 Category: Stem Cells Authors: Bigoni-Ordonez GD, Czarnowski D, Parsons T, Madlambayan GJ, Villa-Diaz LG Tags: Curr Stem Cell Res Ther Source Type: research

Recent biomedical applications on stem cell therapy: A brief overview.
Abstract The unique self-renewal and differentiation ability of stem cells drag the attention of many scientists and researchers towards the clinical application of stem cells. Stem cells are basically the normal living cells of multicellular organisms with some special ability to proliferate and transform into any kind of the body cells with their characteristic feature. Talking about human stem cells, it is originated from various sources like embryonic stem cells, somatic stem cells, hematopoietic stem cells, bone marrow stem cells, neural stem cells etc. which differs in their differentiation potency. On the b...
Source: Current Stem Cell Research and Therapy - October 2, 2018 Category: Stem Cells Authors: Agrawal M, Alexander A, Saraf S, Saraf S, Khan J, Giri TK, Ajazuddin, Patel RJ Tags: Curr Stem Cell Res Ther Source Type: research

Stem cell-based therapies: A New ray of hope for diabetic patients.
Abstract Diabetes and its complications are a significant health concern throughout the globe. There are physiological differences in the mechanism of type-I and type-II diabetes and the conventional drug therapy as well as insulin administration seem insufficient to address the problem at large successfully. Hypoglycemic swings, frequent dose adjustments and resistance to the drug are major problems associated with drug therapy. Cellular approaches through stem cell based therapeutic interventions offer a promising solution to the problem. The need for pancreatic transplants in case of Type-I diabetes can also be...
Source: Current Stem Cell Research and Therapy - October 2, 2018 Category: Stem Cells Authors: Khan J, Alexander A, Agrawal M, Ajazuddin, Dubey SK, Siddique S, Saraf S, Saraf S Tags: Curr Stem Cell Res Ther Source Type: research

Theranostic platforms proposed for cancerous stem cells: A review.
Abstract It is a near-to-impossible not to accept that cancer takes position as the main cause of global burden of disease, for it is hard to ignore the outnumbered people dying from cancer. Looking at the statistics proves that progress in cancer therapy is always beyond cancer in a race of pessimism about the future; for various kinds of cancers yearly cause death in the world, whereas the conventional and even modern therapies often exhibit lack of reliability in treatment of cancer. In principal, various reasons are identified for cancer resistance and recurrence. Recognizing the cells/tissue from which cancer...
Source: Current Stem Cell Research and Therapy - October 2, 2018 Category: Stem Cells Authors: Zarrintaj P, Mostafapoor F, Milan PB, Saeb MR Tags: Curr Stem Cell Res Ther Source Type: research

Differentiation of pluripotent stem cells into nucleus pulposus progenitor cells for intervertebral disc regeneration.
Abstract Low back pain (LBP) is one of the world's most common musculoskeletal diseases, and is frequently associated with intervertebral disc degeneration (IDD). While the main cause of IDD is commonly attributed to a reduced number of nucleus pulposus (NP) cells, current treatment strategies (both surgical and more conservative) fail to replenish NP cells or reverse the pathology. Cell replacement therapies are an attractive alternative for treating IDD. However, injecting intervertebral disc (IVD) cells, chondrocytes, or mesenchymal stem cells into various animal models of IDD indicate that transplanted cells g...
Source: Current Stem Cell Research and Therapy - September 17, 2018 Category: Stem Cells Authors: Xia K, Gong Z, Zhu J, Yu W, Wang Y, Wang J, Xu A, Zhou X, Tao H, Li F, Liang C Tags: Curr Stem Cell Res Ther Source Type: research

Ductal cell reprogramming to insulin-producing beta-like cells as a potential beta cell replacement source for chronic pancreatitis.
Abstract Islet cell auto-transplantation is a novel strategy for maintaining blood glucose levels and improving the quality of life in patients with chronic pancreatitis (CP). Despite the many recent advances associated with this therapy, obtaining a good yield of islet infusate still remains a pressing challenge. Reprogramming technology, by making use of the pancreatic exocrine compartment, can open the possibility of generating novel insulin-producing cells. Several lineage-tracing studies present evidence that exocrine cells undergo dedifferentiation into a progenitor-like state from which they can be manipula...
Source: Current Stem Cell Research and Therapy - September 17, 2018 Category: Stem Cells Authors: Jawahar AP, Narayanan S, Loganathan G, Pradeep J, Vitale GC, Hughes MG, Williams SK, Balamurugan AN Tags: Curr Stem Cell Res Ther Source Type: research

Neuroprotective Effects of Trolox, Human Chorionic Gonadotropin, and Carnosic Acid on Hippocampal Neurodegeneration After Ischemia-reperfusion Injury.
CONCLUSION: Findings indicate the beneficial effects of HCG and Trolox on the improvement of memory and the number of healthy cells in the hippocampal region. It is worth noting that the amount of apoptosis in the hippocampus was significantly reduced by Trolox, HCG and Carnosic acid. PMID: 30227824 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - September 17, 2018 Category: Stem Cells Authors: Babahajian A, Sarveazad A, Golab F, Vahabzadeh G, Alizadeh A, Rasoolijazi H, Amini N, Entezari M, Soleimani M, Katebi M Tags: Curr Stem Cell Res Ther Source Type: research

The clinical trials of mesenchymal stem cell therapy in skin diseases: an update and concise review.
In this study, we review the clinical trials using MSCs in skin diseases. A remarkable number of clinical trial studies are in progress in this field, however, some have had early benefits to patients. We discuss here relevant papers and ongoing clinical trials that address MSC's therapeutic goals for various skin disorders, while this review can be very useful for both dermatologists and basic skin researchers, with the aim of contributing to stem cell-based therapeutic research in the area of skin disorders. PMID: 30210006 [PubMed - as supplied by publisher] (Source: Current Stem Cell Research and Therapy)
Source: Current Stem Cell Research and Therapy - September 13, 2018 Category: Stem Cells Authors: Golchin A, Farahany TZ, Khojasteh A, Ardeshirylajimi A Tags: Curr Stem Cell Res Ther Source Type: research

A mini-review: the therapeutic potential of mesenchymal stem cells and relevant signaling factors.
Abstract Mesenchymal stem cells (MSCs), with its capacity of multi-directional differentiation, low immunogenicity and high portability, which made BMSCs serve as ideal "seed cells" in ophthalmological disease therapy. Therefore, in this mini-review we examined recent literature concerning the potential application of MSCs for the treatment of ophthalmological disease, which including : activity of transplanted cells, migration and homing of MSCs, immuno-modulatory and anti-inflammatory effects of MSCs and signaling involved. Each aspect is complementary to the others and together these aspects promoted ...
Source: Current Stem Cell Research and Therapy - September 12, 2018 Category: Stem Cells Authors: Yang W, Ma B Tags: Curr Stem Cell Res Ther Source Type: research

CellSaic, a Cell Aggregate-like Technology Using Recombinant Peptide Pieces for MSC Transplantation.
Abstract In the field of stem cell therapy, research on the application of mesenchymal stem cells (MSCs) has flourished because of the various functions. On the other hand, research on the method of cell transplantation has developed from the administration of cell suspensions to cell-sheet engineering and 3D technology. In the trend, a cell transplantation platform named CellSaic, which is a combination of xeno-free recombinant scaffolds in a cell aggregate-like shape, was developed. CellSaic is the cell transplantation platform that can prevent the central necrosis within cell aggregates by arranging the cells a...
Source: Current Stem Cell Research and Therapy - September 12, 2018 Category: Stem Cells Authors: Nakamura K Tags: Curr Stem Cell Res Ther Source Type: research