Ultra-Wide-Field Imaging in Uveitis.
Authors: Cunningham ET, Munk MR, Kiss S, Zierhut M PMID: 31184555 [PubMed - in process] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - June 13, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Differentiation of Underlying Pathologies of Macular Edema Using Spectral Domain Optical Coherence Tomography (SD-OCT).
Conclusions: Macular edema of different origins show characteristic patterns that are often indicative of the underlying cause and pathology. Thus, trained algorithms may in the future be able to automatically differentiate underlying causes and support clinical diagnosis. Knowledge of different appearances support the clinical diagnosis and can lead to improved and more targeted treatment of ME. PMID: 31184556 [PubMed - in process] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - June 13, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Local Cytokine Expression Profiling in Patients with Specific Autoimmune Uveitic Entities.
Conclusions: IL-11-driven immune responses might be more potent in nongranulomatous uveitis, particularly in HLA-B27 uveitis. BAFF and APRIL might contribute to B cell-driven autoimmune response in uveitis. PMID: 31161935 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - June 6, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

The Results of Interferon-Alpha Treatment in Beh çet Uveitis.
Conclusion: IFN-α seems an effective and safe treatment option in the management of refractory BU. PMID: 31161949 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - June 6, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Development of Acute Vogt-Koyanagi-Harada-like Syndrome during the Treatment Course with Vemurafenib for Metastatic Melanoma.
Conclusions: Vemurafenib, a potential adjunct treatment for metastatic melanoma, was complicated by the development of panuveitis, papillitis, and multiple serous detachments. These ocular symptoms were similar to the presentation of acute VKH syndrome. PMID: 31161956 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - June 6, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Presenting Features, Treatment and Clinical Outcomes of Cytomegalovirus Retinitis: Non-HIV Patients Vs HIV Patients.
Conclusion: CMV retinitis can present with different features depending on the cause of immunocompromise. Evidence of intraocular inflammation such as vitritis, retinal arteritis, and vascular occlusions was more common in HIV-negative subjects. PMID: 31166809 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - June 6, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Multiple Granulomas of Ocular Toxocariasis in an Immunocompetent Male.
Authors: Agarwal A, Das P, Kumar A, Sharma S, Aggarwal K, Sehgal S, Gupta V Abstract A 25-year-old male presented with unilateral panuveitis with multiple voluminous elevated retinal lesions along with subretinal fluid and exudation. An extensive laboratory work-up was done, and a clinical suspicion of viral retinitis was considered. The patient was initiated on antiviral therapy and, subsequently, oral corticosteroids. As the corticosteroids were tapered, the patient developed worsening lesions and vitreous inflammation. Pars plana vitrectomy (diagnostic and therapeutic) was performed and cytology sample revealed ...
Source: Ocular Immunology and Inflammation - June 5, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Ultra-Widefield Fundus Autofluorescence in Cytomegalovirus Retinitis.
Conclusion: UWF-FAF is useful in the management of CMV retinitis. PMID: 31136217 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - May 30, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Self-Reported Quality of Life in Patients with Long-Standing Vogt-Koyanagi-Harada Disease.
Conclusions: On HR- and VR-QoL questionnaires difficulties perceived by patients with long-standing VKHD were mainly associated with socio-economic aspects, VA, local treatment and ocular complications. PMID: 31136253 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - May 30, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Intra-silicone Oil Injection of Methotrexate in Retinal Reattachment Surgery for Proliferative Vitreoretinopathy.
Conclusion: The rate of redetachment associated with PVR was lower after intrasilicone injection of MTX at the end of vitrectomy for RRD with severe PVR compared to control group; however, the difference was not statistically significant. PMID: 31136255 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - May 30, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Diagnostic Performance of MALDI-TOF MS Compared to Conventional Microbiological Cultures in Patients with Suspected Endophthalmitis.
Authors: Xu S, Zhou C, Zhang P, Feng C, Zhang T, Sun Z, Zhuang H, Chen H, Chang Q, Jiang R, Li H, Ni Y Abstract Purpose: To evaluate the performance and speed of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) when identifying the pathogenic microorganism of endophthalmitis compared to conventional microbiological culturing. Methods: Forty-four patients with suspected endophthalmitis who had undergone vitrectomy were enrolled. Vitreous specimen was analyzed using either conventional culturing or MALDI-TOF MS. Results: The identification rates of the conventional microbiol...
Source: Ocular Immunology and Inflammation - May 24, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Vogt-Koyanagi-Harada Syndrome in Brazilian Children.
Conclusion Visual outcomes were favorable in half of patients depending on the long-term sequelae. VKH is rarely reported in children and it may be sight-threatening, and requires careful attention, being an important differential diagnosis. PMID: 31120768 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - May 24, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

The Effect of Cytokine-Stimulation and Pharmacologic Intervention on PGE2 Production in Primary Human Conjunctival and Corneal Cells.
Authors: Shimizu E, Yazu H, Satake Y, Fukagawa K, Aketa N, Murat D, Okada N, Fujishima H Abstract We studied the production of PGE2 by human conjunctival and corneal cells in response to inflammation, and reduction of inflammation with non-steroidal anti-inflammatory drugs. Primary cultures of human conjunctival epithelial cells, fibroblasts, corneal epithelial cells, and keratocytes were incubated with IL-4 and TNF-α. PGE2 and COX-2 levels were analyzed. Effects of anti-inflammatory and anti-immune drugs on PGE2 production were also investigated. IL-4 and TNF-α induced the generation of PGE2 and COX-2 ...
Source: Ocular Immunology and Inflammation - May 24, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Interferon Alpha-2a Treatment for Post-Uveitic Refractory Macular Edema.
Authors: De Simone L, Sangiovanni A, Aldigeri R, Mastrofilippo V, Bolletta E, Invernizzi A, Fares L, Pipitone N, Fontana L, Salvarani C, Cimino L Abstract PURPOSE: To assess the efficacy of interferon (IFN) alpha-2a in the treatment of post-uveitic refractory macular edema (ME). METHODS: Retrospective cohort of patients with post-uveitic refractory ME, who received subcutaneous IFN alpha-2a injections for at least 3 months. Baseline central macular thickness (CMT) and best-corrected visual acuity (BCVA) were compared with those at follow-up visits up to 12 months. RESULTS: Thirty-seven patients were include...
Source: Ocular Immunology and Inflammation - May 21, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

In Response To: Lapere S, Mustak H and Steffen J. "Clinical Manifestations and Cerebrospinal Fluid Status in Ocular Syphilis".
In Response To: Lapere S, Mustak H and Steffen J. "Clinical Manifestations and Cerebrospinal Fluid Status in Ocular Syphilis". Ocul Immunol Inflamm. 2019 Apr 25;:1-2 Authors: Smit DP, de Groot-Mijnes JDF PMID: 31020868 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 27, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Pattern of Retinal Vasculitis in an Egyptian Cohort.
CONCLUSION: In our Egyptian cohort, more than half the patients had their retinal vasculitis as part of a serious systemic disease, or as part of an infectious process, as tuberculosis. And in view of the significant potential morbidity of these conditions, the local ophthalmologists need to be aware of these entities when faced with patients presenting with retinal vasculitis. PMID: 31020877 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 27, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Characteristics and Clinical Outcomes of Hypertensive Anterior Uveitis.
CONCLUSION: Viral infection was found in one half of hypertensive anterior uveitis. The complications of PCR-proven infectious case were more severe than PCR-negative case. PMID: 31020885 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 27, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Events Calendar.
Authors: PMID: 31014205 [PubMed - in process] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 26, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Editorial 2019 for Ocular Immunology and Inflammation.
Authors: Zierhut M PMID: 31014206 [PubMed - in process] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 26, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Pattern and Outcome of Uveitis in a Tertiary Military Hospital in Thailand.
The objective of the study is to analyze pattern and outcome of uveitis in Phramongkutklao Hospital. METHODS: This is a retrospective study. RESULTS: Rate of uveitis was 580 cases per 100 000 persons including infectious uveitis (20%), idiopathic (36%), and noninfectious (44%). The male-to-female ratio was 1.2:1. Anterior uveitis was the most common (50%) followed by panuveitis (25.6%), posterior uveitis (12.3%), and intermediate uveitis (7.3%). The three most common causes were Behçet's disease, HLA-B27-associated uveitis, and herpetic iridocyclitis. A total of 62 patients (10.6%) suffered from blindne...
Source: Ocular Immunology and Inflammation - April 24, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Serum Vitamin D Levels in Patients with Keratoconus.
This study included 100 patients with KC and 100 non-atopic healthy controls. Serum vitamin D levels were measured using liquid chromatography-tandem mass spectrometry and compared between the study groups. KC severity was graded as mild (K = 43.1-46.9 D), moderate (K = 47-50 D), and severe (K > 50 D). Vitamin D levels were classified as deficient (≤10 ng/mL), insufficient (11-20 ng/mL), and optimal (>20 ng/mL). RESULTS: The mean serum vitamin D level was significantly lower in the KC group than in the control group (12.18 ± 5.05 ...
Source: Ocular Immunology and Inflammation - April 24, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Intraocular Concentrations of Cytokines and Chemokines in a Unique Case of Nivolumab-Induced Uveitis.
CONCLUSION: This case indicates that nivolumab-induced uveitis might be more severe in eyes with a damaged iris, and that vitrectomy should be effective for vitreous opacity. A cytokine analysis of the ocular fluid indicated that multiple types of cell might be related to the inflammation process. PMID: 31012778 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 24, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Ocular Adverse Events following Use of Immune Checkpoint Inhibitors for Metastatic Malignancies.
CONCLUSION: We found a wide spectrum of ocular irAEs associated with immune checkpoint inhibitors. In most cases, ocular AEs did not limit ongoing cancer treatment. PMID: 31013173 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 24, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Therapeutic Changes in Bilateral Choroidal Metastasis from Non-Small Cell Lung Cancer with Response to Afatinib: A Case Report.
Authors: Zhou HP, Tanaka R, Tsuji H Abstract A 49-year-old male presented with a three-day onset of blurred vision and metamorphopsia in the left eye. Fundoscopy and OCT images identified multiple subretinal masses with associating serous retinal detachment in both eyes. Bilateral choroidal metastasis was suspected, and further evaluation revealed a mass in the lower left lobe of the lung with multiple metastatic loci. Ultimately, the patient was diagnosed with Stage IVB (T2aN2M1c) adenocarcinoma of the lung. Genetic analysis revealed an exon 19 deletion mutation in the epidermal growth factor receptor (EGFR) gene....
Source: Ocular Immunology and Inflammation - April 24, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Long-Term Intravitreal Dexamethasone Implant Outcomes in Uveitis.
CONCLUSIONS: The dexamethasone implant provides favorable VA, CRT, and VHS long-term outcomes in uveitis with a reduced rate of severe adverse events. PMID: 30994370 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 19, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

The Relation of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio with High Axial Myopia.
CONCLUSION: NLR and PLR values in cases with high axial myopia were higher than in the emmetropic group. Higher inflammation in the degenerative myopic group in particular may be related to pathological chorioretinal changes. PMID: 30994377 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 19, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Long-Term Outcome of Punctate Inner Choroidopathy or Multifocal Choroiditis with Active Choroidal Neovascularization Managed with Intravitreal Bevacizumab.
CONCLUSION: Most patients of PIC/MFC complicated with CNV managed with intravitreal bevacizumab had improved BCVA over 4 years. PMID: 30994378 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 19, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Evaluation of the Efficacy and Safety of A Novel 0.05% Cyclosporin A Topical Nanoemulsion in Primary Sj ögren's Syndrome Dry Eye.
Evaluation of the Efficacy and Safety of A Novel 0.05% Cyclosporin A Topical Nanoemulsion in Primary Sjögren's Syndrome Dry Eye. Ocul Immunol Inflamm. 2019 Apr 15;:1-9 Authors: Kang MJ, Kim YH, Chou M, Hwang J, Cheon EJ, Lee HJ, Chung SH Abstract PURPOSE: To evaluate the efficacy and safety of a novel topical cyclosporin A 0.05% nanoemulsion in comparison with a conventional emulsion in primary Sjögren's syndrome dry eyes. METHODS: Prospective, randomized, double-blinded study was conducted. RESULTS: Corneal and conjunctival staining score was improved in both groups, with a faster ch...
Source: Ocular Immunology and Inflammation - April 17, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Resolution of Large Choroidal Tuberculoma following Monotherapy with Intravitreal Ranibizumab.
CONCLUSIONS: Ranibizumab monotherapy may lead in complete regression of vascularized tubercular choroidal granulomas without the need of adjunctive ATT and corticosteroids. After intravitreal injection of ranibizumab, the lesion may be observed for regression over several weeks. PMID: 30986122 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 17, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Interferon Alpha for Refractory Pseudophakic Cystoid Macular Edema (Irvine-Gass Syndrome).
Authors: Dimopoulos S, Deuter CME, Blumenstock G, Zierhut M, Dimopoulou A, Voykov B, Bartz-Schmidt KU, Doycheva D Abstract PURPOSE: To assess the efficacy and safety of systemic interferon alpha-2a (IFN) for refractory pseudophakic cystoid macular edema (PCME). METHODS: Retrospective observational study. The primary outcome was the decrease of central retinal thickness (CRT). Secondary endpoints were the improvement of best-corrected visual acuity (BCVA) and the assessment of IFN-related side effects. RESULTS: Twenty-four eyes of 20 patients were included. The median CRT was 513 µm (range 220-980 &mic...
Source: Ocular Immunology and Inflammation - April 17, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Bilateral Acute Depigmentation of the Iris: Findings in Anterior Segment Swept-Source Optical Coherence Tomography.
CONCLUSIONS: AS-SS OCT findings, not previously described, locate the damage in BADI in the anterior edge and iridian stroma, areas which are rich in melanocytes and permeable to aqueous humor. PMID: 30986124 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 17, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Early Onset Neovascular Inflammatory Vitreoretinopathy Due to a De Novo CAPN5 Mutation: Report of a Case.
This report of vision and hearing loss in a 3 year-old girl describes the youngest documented case of ADNIV due to a de novo pathogenic c.865C>T (p.Arg289Trp) CAPN5 variant, illustrating the early stages of this enigmatic disease process. PMID: 30986125 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 17, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Extended Wear Bandage Contact Lenses Decrease Pain and Preserve Vision in Patients with Epidermolysis Bullosa: Case Series and Review of Literature.
CONCLUSIONS: Continuous and prolonged BCL therapy in patients with EB can be an effective way to immediately alleviate pain, prevent recurrent abrasions, and improve patient quality of life. PMID: 30986129 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 17, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Higher TGF- β2 Level in the Aqueous Humor of the Second Eye Versus the First Eye in the Course of Sequential Cataract Surgery.
CONCLUSION: During bilateral sequential cataract surgery, the AH of the second eye had a higher level of TGF-β2 but not of proinflammatory cytokines or chemokines compared with those in the first eye, implying a protective mechanism preventing the sympathetic immune reaction induced by the first-eye cataract surgery. PMID: 30973281 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 13, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

TIMP-1 Mediates Inflammatory and Immune Response to IL-6 in Adult Orbital Xanthogranulomatous Disease.
CONCLUSION: These data implied that the IL6~JAK2/STAT3-TIMP-1 signalling pathway is activated in AOXGD and that adaptive Th1 and Th17 responses are involved in the development of AOXGD. PMID: 30973282 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 13, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Assessment of Monocyte/HDL Ratio in Branch Retinal Vein Occlusion.
CONCLUSION: The present study showed that elevated MHR is significantly associated with BRVO. Therefore, MHR may be a useful marker for the emergence of BRVO. PMID: 30966842 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 12, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Anti-Inflammatory Effect of Dehydroxymethylepoxyquinomicin, a Nuclear factor- κB Inhibitor, on Endotoxin-Induced Uveitis in Rats In vivo and In vitro.
CONCLUSIONS: The results indicate that DHMEQ has anti-inflammatory effects on EIU and may be a promising agent to treat intraocular inflammation. PMID: 30950670 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - April 7, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

The Uveitis Patient Passport: A Self-Care Tool.
CONCLUSION: The introduction of the first UPP was a success, especially as a self-care tool for supporting patients in managing their uveitis with the potential to improve patient outcomes. PMID: 30821566 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - March 4, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Uveitis in Patients Treated with CTLA-4 and PD-1 Checkpoint Blockade Inhibition.
CONCLUSIONS: Patients on checkpoint inhibitor therapy should be educated to seek care if they develop ocular symptoms, and prompt referral to specialists should be incorporated into oncology protocols. PMID: 30821569 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - March 4, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Epidemiology of Macular Edema in Uveitis.
CONCLUSION: Older age, chronicity of uveitis and intermediate uveitis are risk factors for the development of ME in patients with uveitis. PMID: 30821631 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - March 4, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Ocular Features in Chinese Patients with Blau Syndrome.
CONCLUSIONS: Blau syndrome is a rare autosomal dominant multisystem disease caused by a NOD2 gene defect. Recurrent anterior uveitis and/or panuveitis are the characteristic ocular findings. PMID: 30806112 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - February 28, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Comparisons of Clinical Features in Japanese Patients with Beh çet's Uveitis Treated in the 1990s and the 2000s.
CONCLUSIONS: Milder ocular BD tendency was seen in cases in the 2000s, whereas the incidence of special type of BD might be increasing. PMID: 30806114 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - February 28, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Interstitial Keratitis with Corneal Perforation as the Presenting Sign of Systemic Tuberculosis.
CONCLUSIONS: Although corneal involvement is uncommon in ocular tuberculosis, in patients with interstitial keratitis who respond poorly to conventional therapy, a possibility of systemic tuberculosis should be considered in endemic countries. PMID: 30806115 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - February 28, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Current Practices in Ocular Tuberculosis: A Survey of Brazilian Specialists.
CONCLUSIONS: TST remains the preferred method for TBU diagnosis and prompt treatment by Brazilian specialists, though there is no consensus regarding disease treatment and management. PMID: 30806119 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - February 28, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Revisiting Ocular Allergy: Evaluating Symptoms, Benzalkonium Chloride and Efficacy of Topical Ketotifen 0.025.
Authors: Boboridis KG, Kozeis N, Konstas AG Abstract This interesting study raises a scientific issue for revisiting three important elements on diagnosis, use of preservatives and selection of the appropriate topical treatment. Itchy feeling can be encountered in other ophthalmic conditions misdiagnosed as allergy, benzalkonium chloride is responsible for surface toxicity resulting in reduced efficacy and tolerability of topical allergy medications and it should be avoided on the management of ocular allergy. Unpreserved ketotifen 0,025% has been shown to be the least toxic formulation being the optimum option for...
Source: Ocular Immunology and Inflammation - February 28, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Clinical Features, Treatment, and Visual Outcomes of Japanese Patients with Posterior Scleritis.
Authors: Ando Y, Keino H, Nakayama M, Watanabe T, Okada AA Abstract PURPOSE: The purpose of this study is to describe clinical features and visual outcomes of Japanese patients with posterior scleritis. METHODS: Clinical records of 10 patients (13 eyes) presenting between 2006 and 2016 were retrospectively reviewed. RESULTS: The mean age was 50.1 ± 20.8 years; 50% were women, and three patients had bilateral disease. Associated anterior scleritis (11 eyes, 85%) and serous retinal detachment (8 eyes, 62%) were common at presentation. Treatment consisted of corticosteroids (all patients)...
Source: Ocular Immunology and Inflammation - February 28, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Alterations of Tear Film and Ocular Surface in Children with Type 1 Diabetes Mellitus.
CONCLUSION: Diabetic children without symptoms, signs, and definite diagnosis of dry eye still had lower TBUT and Schirmer test results than controls; however, impression cytology analysis was similar in both groups. PMID: 30806526 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - February 28, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Clinical Evaluation of Intravitreal Injection of Ganciclovir in Refractory Corneal Endotheliitis.
CONCLUSIONS: CMV endotheliitis was the main type of refractory endotheliitis. Despite its invasive nature, intravitreal GCV injection appears to be an effective method for refractory endotheliitis. PMID: 30806530 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - February 28, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Effectiveness of Treatments for Ocular Toxoplasmosis.
CONCLUSIONS: All treatments were effective for active episodes of OT, with few side effects. PMID: 30806556 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - February 28, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Klebsiella Pneumoniae Endogenous Endophthalmitis Mimicking a Choroidal Neovascular Membrane with Subretinal Hemorrhage.
CONCLUSIONS: In patients with coagulopathy due to liver disease, EE may present with submacular hemorrhage mimicking a CNVM. Clinicians must be cognizant of this fact as delay in instituting appropriate antibiotic therapy can lead to loss of the eye. PMID: 30806565 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - February 28, 2019 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research