Klotho Levels are Decreased and Associated with Enhanced Oxidative Stress and Inflammation in the Aqueous Humor in Patients with Exudative Age-related Macular Degeneration.
CONCLUSION: Klotho levels in the aqueous humor are decreased and associated with oxidative stress and inflammation in patients with exudative AMD. PMID: 33048602 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - October 15, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Paraneoplastic Pemphigus Associated with Bilateral Corneal Perforations in Follicular Dendritic Cell Sarcoma.
CONCLUSIONS: Ocular manifestations of PNP can rarely present with spontaneous corneal perforations. This is the first case of FDCS-associated PNP with corneal involvement. Such cases should be diagnosed expediently and managed with aggressive systemic immunosuppressive therapy. PMID: 33048604 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - October 15, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Endophthalmitis in Eyes with Osteo-odonto Keratoprosthesis.
Conclusion: Endophthalmitis portends a grave prognosis for eyes with OOKP. The most important risk factors are SJS (75%) and lamina resorption (88%). PMID: 33026270 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - October 9, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Does Pharmaceutical Compounding of Vascular Endothelial Growth Factor Inhibitors for Intravitreal Use Alter the Risk of Post-injection Endophthalmitis?
CONCLUSION: Use of compounded anti-VEGF drugs in a large clinical setting was not associated with an altered risk of PIE. The finding adds to the evidence that splitting of vials into prefilled syringes for intravitreal injections is safe, provided that an appropriate pharmaceutical compounding procedure is strictly followed. PMID: 33026900 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - October 9, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Dysregulation of the NLRP3 Inflammasome in Diabetic Retinopathy and Potential Therapeutic Targets.
Authors: Raman KS, Matsubara JA Abstract Diabetic Retinopathy (DR) is an insidious neurovascular disorder secondary to chronic glycemic dysregulation in elderly diabetic patients. In the later stages of DR, the disease manifests as fluid infiltrating the macula, culminating in the leading cause of irreversible visual impairment in working age adults. With the current mainstay treatments preoccupied with slowing down the progression of DR, this presents an unsustainable solution from both an economic and quality of life perspective. Although the exact mechanisms by which hyperglycemia leads to retinal tissue insult ...
Source: Ocular Immunology and Inflammation - October 9, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Enhanced Ectasia Screening in Patients with Uveitis and Isolated Systemic Inflammatory Disease.
Authors: Toprak I, Cetin EN, Akbulut S, Pekel G, Yuksel S, Cobankara V Abstract PURPOSE: To investigate corneal topographic alterations in patients with uveitis and isolated systemic inflammatory disease (SID). METHODS: This retrospective cross-sectional study included 44 patients with uveitis with anterior chamber inflammation (uveitis group), 39 subjects with isolated SID, and 91 healthy controls (control group). Topographic images were classified as "normal," "keratoconus (KC) suspect" and "KC" based on maps of axial curvature, corneal thickness, front and back elevation in comb...
Source: Ocular Immunology and Inflammation - October 9, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Correlation between Subfoveal Choroidal Thickness and Anterior Segment Inflammation in Patients with Chronic Stage of Vogt-Koyanagi-Harada Disease.
Authors: Ormaechea MS, Hassan M, Mahajan S, Nguyen QD, Couto C, Schlaen A Abstract PURPOSE: To correlate changes in subfoveal choroidal thickness (SCT) with the degree of anterior inflammatory activity in chronic Vogt-Koyanagi-Harada (VKH) disease. METHODS: Anterior segment inflammation was assessed using SUN anterior chamber cell grading criteria, and SCT was measured using EDI-OCT in patients with VKH at multiple visits. ANOVA was used to compare the mean SCT for each anterior chamber cell grade. Regression analysis was used to correlate the anterior segment cell grade and the SCT. RESULTS: 14 patients we...
Source: Ocular Immunology and Inflammation - October 7, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Risk factors for subretinal fibrosis in patients with Vogt Koyanagi Harada syndrome.
Conclusion: Patients with VKH syndrome who develop a bullous retinal detachment have an 8 times higher risk of developing SRF in the long term. PMID: 33021860 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - October 7, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Challenges in Post-cataract Surgery Nocardia Endophthalmitis: Management Strategies and Clinical Outcomes.
CONCLUSIONS: We did not find any significant association between functional outcome and time of surgery or presenting VA. Additional amikacin may be considered if there is a strong suspicion of nocardia endophthalmitis, as it may help in achieving better anatomical outcomes. PMID: 33021862 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - October 7, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

HIV/AIDS and the Eye.
Authors: Cunningham ET, Zierhut M PMID: 32997584 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - October 1, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Efficacy of B Cell Depletion Therapy with Rituximab in Refractory Chronic Recurrent Uveitis Associated with Vogt-Koyanagi-Harada Disease.
Authors: Abu El-Asrar AM, Dheyab A, Khatib D, Struyf S, Van Damme J, Opdenakker G Abstract PURPOSE: To evaluate the efficacy of B cell depletion therapy with the chimeric mouse/human anti-CD20 monoclonal antibody rituximab for refractory chronic recurrent granulomatous uveitis associated with Vogt-Koyanagi-Harada (VKH) disease. METHODS: Retrospective study of 9 patients (18 eyes) who failed to respond to conventional combination immunosuppressive therapy. RESULTS: All the patients received 3 rituximab infusions. The follow-up period after initiation of rituximab therapy ranged from 9 to 36 months (mean...
Source: Ocular Immunology and Inflammation - September 30, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Increased Systemic Immune-Inflammation Index Levels in Patients with Dry Eye Disease.
Authors: Ozarslan Ozcan D, Kurtul BE, Ozcan SC, Elbeyli A Abstract PURPOSE: To evaluate the systemic immune-inflammation index (SII) levels, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in patients with dry eye disease (DED) and to compare with control subjects. METHODS: This prospective study included 47 DED patients and 47 age- and sex-matched healthy controls. Ophthalmological examination, diagnostic DED tests, and routine complete blood cell count parameters were analyzed. The SII value was calculated as follows: platelet count × (neutrophil/lymphocyte). RESULTS: Th...
Source: Ocular Immunology and Inflammation - September 30, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Ocular Gnathostomiasis Presenting as Branch Retinal Artery Occlusion.
CONCLUSION: Branched retinal artery occlusion with intraretinal and vitreous hemorrhage, panuveitis, and multiple iris holes may suggest the presence of an intraocular parasite. PMID: 32990490 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 30, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Extensive Dynamics of Aneurysms and Long-term Prognosis in IRVAN Syndrome: A Case Series.
CONCLUSION: IRVAN syndrome is a rare condition that may progress rapidly and cause severe vision loss without treatment. The photocoagulation is beneficial and should be performed in the early phase. The aneurysms presented extensive dynamic changes through multimodal imaging which suggested a migratory inflammatory process involving retinal arterioles. PMID: 32990491 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 30, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Floral Pattern of Keratic Precipitates in Vitreoretinal Lymphoma on In Vivo Confocal Microscopy.
CONCLUSION: In addition to the routinely used clinical and imaging markers like the visual acuity, presence of lymphomatous cells in the vitreous and optical coherence tomography findings, the presence and appearance of KPs on IVCM can also be considered as a useful, diagnostic and treatment monitoring marker in VRL. PMID: 32990493 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 30, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Visual Recovery with Iloprost Added to Corticosteroids in a Case of Giant Cell Arteritis.
CONCLUSION: This case highlights the potential role of vasodilatator agents in giant cell arteritis with ocular involvement. PMID: 32976035 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 27, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Management of Juvenile Idiopathic Arthritis-associated Uveitis during the COVID-19 Pandemic in a Pediatric Referral Center in Lombardy.
Authors: Miserocchi E, Giuffrè C, Modorati GM, Cimaz R Abstract Italy was the first European country to be affected by the SARS-CoV-2 pandemic. In this scenario, we had to face a new clinical approach in our Pediatric Rheumatology Unit for the management of patients affected by juvenile idiopathic arthritis (JIA)-associated uveitis. During the lockdown (phase 1), the weekly outpatient clinic was discontinued and telephone consultations were set up. A toll-free telephone number was instituted for emergencies. None of our children with JIA-associated uveitis was advised to stop the ongoing immunosuppressant sy...
Source: Ocular Immunology and Inflammation - September 27, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Subretinal Hemorrhage Complicating Retinal Angiomatous Proliferation in Tubercular Retinal Vasculitis.
CONCLUSION: This case highlights that rare vascular alterations such as RAP can develop in subjects with ocular tuberculosis. PMID: 32976040 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 27, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Anterior Segment Inflammation in Pediatric Uveitis Is Associated with Reduced Retinal Vascular Density as Quantified by Optical Coherence Tomography Angiography.
Authors: Qu Y, Zhao C, Pei M, Liang A, Gao F, Zhang M Abstract PURPOSE: To analyze the retinal capillary vascular density (VD) as quantified by optical coherence tomography angiography (OCTA) in patients with pediatric uveitis. METHODS: OCTA images of 32 pediatric uveitis patients and 30 normal controls (NC) were obtained retrospectively. The foveal avascular zone (FAZ) area, VDs in the superficial capillary plexus (SCP) and deep capillary plexus (DCP), the central macular thickness (CMT), and subfoveal choroidal thickness (SFCT) were analyzed and compared between active and quiescent uveitic eyes, contralatera...
Source: Ocular Immunology and Inflammation - September 27, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Ocular Toxoplasmosis in Africa: A Narrative Review of the Literature.
CONCLUSION: As Toxoplasma gondii has more virulent strains in the Southern hemisphere, it is relevant to determine African strain types and the correlation between the infecting strains and the clinical manifestations. PMID: 32976046 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 27, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Orchestrating Collaborative Research and Clinical Trials during COVID-19 Pandemic - A New Normal.
Authors: Agrawal R PMID: 32976047 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 27, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Reply: Anterior Uveitis Due to Intracameral Moxifloxacin: A Case Report.
Authors: Muñoz-Ortiz J, Reyes-Guanes J, de-la-Torre A PMID: 32976052 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 27, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Impending Central Retinal Vein Occlusion in a Patient with Coronavirus Disease 2019 (COVID-19).
CONCLUSIONS: Retinal circulation should be considered as a potential site for thromboembolic complications from COVID-19. PMID: 32976055 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 27, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Unilateral Acute Iris Transillumination-like Syndrome following Intracameral Moxifloxacin Injection.
CONCLUSION: BAIT-like syndrome may be a rare side effect of intracameral moxifloxacin. PMID: 32976059 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 27, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Ocular Disease in Mice Inoculated with Pork Heart Samples Infected with Toxoplasma gondii.
Conclusion: Our findings have shown that pork eat from southern Brazil may contain live T. gondii that could be associated with toxoplasmosis. PMID: 32976068 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 27, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Imaging in Tubercular Choroiditis: Current Concepts.
CONCLUSIONS: Fundus imaging plays a vital role in the diagnosis and management of patients with posterior uveitis due to tuberculosis. Fundus imaging may have a useful role in defining clinical endpoints for ocular tuberculosis in the future. PMID: 32976732 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 27, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Optic Nerve Infiltration in Systemic Metastatic Retinal Lymphoma (SMRL): Multimodal Imaging and Challenges in Diagnosis.
CONCLUSION: Optic nerve infiltration in systemic metastatic retinal lymphoma may have initial occult signs but with profound visual loss. Ocular infections like CMV retinitis and tuberculosis may mask and delay the diagnosis in immunocompromised patients. PMID: 32967510 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 26, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

HLA-DRB1*04:05 and HLA-DQB1*04:01: Alleles Potentially Associated with Vogt-Koyanagi-Harada in Northern Thai Patients.
Conclusion HLA-DRB1*04:05 and HLA-DQB1*04:01 could be potential genetic markers for VKH. PMID: 32965138 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 24, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Uveal Infiltration in an Acute Myeloid Leukemia Case.
CONCLUSION: Severe extramedullary relapse in the eye might occur during chemotherapy intermission. PMID: 32965139 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 24, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Multidisciplinary Diagnostic Approach in Intraocular Lymphoma Featuring Pseudo-hypopyon: Case Series and Literature Review.
CONCLUSION: Pseudo-hypopyon is a rare feature of IOL, more commonly seen in secondary IOL, which can be accompanied by hyphema and high intraocular pressure. Supplementary diagnostic tools such as flow cytometric immunophenotyping, interleukin analysis, and immunogloblin H gene rearrangement analysis are useful for supporting the diagnosis of IOL with pseudo-hypopyon. PMID: 32965144 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 24, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Tocilizumab versus Rituximab in Patients with Moderate to Severe Steroid-resistant Graves' Orbitopathy.
CONCLUSION: We showed a significant improvement in the CAS, visual acuity, diplopia, and proptosis with both tocilizumab and rituximab. PMID: 32965148 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 24, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Chalazia, A Late Manifestation of Primary Immunodeficiency Disorders.
Authors: Bargir UA, Madkaikar M Abstract PURPOSE: To call attention to the central clues for primary immunodeficiency in the cases reported by María Nieves-Moreno et. al where chalazia in the reported cases is undoubtedly an important clue but is a late clinical manifestation. PMID: 32965149 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 24, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Klebsiella Cluster Endophthalmitis following Intravitreal Bevacizumab: Role of Early Detection, Pars Plana Vitrectomy, and Intracameral Moxifloxacin.
CONCLUSION: Early detection and prompt PPV were effectual for achieving good functional outcomes in our cluster of post-IVB Klebsiella endophthalmitis. Intracameral moxifloxacin was protective in cases undergoing combined cataract surgery with IVB. PMID: 32965152 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 24, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Diagnostic and Prognostic Roles of Serum Interleukin-6 Levels in Patients with Uveitis.
Authors: Maleki A, Gomez S, Asgari S, Bosenberg Z, Manhapra A, Walsh M, Weng A, Tseng C, He C, Anesi SD, Foster CS Abstract PURPOSE: To examine the diagnostic and prognostic roles of serum interleukin-6 levels in patients with uveitis. METHODS: This was a retrospective observational case series. Demographic and clinical characteristics were compared between Group One (sixty patients) with normal serum IL-6 levels and Group Two (twenty patients) with high serum interleukin-6 levels. RESULTS: Mean IL-6 level was 1.77 ± 0.97 pg/ml and 10.2 ± 9.7 pg/ml in Group One an...
Source: Ocular Immunology and Inflammation - September 24, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Serial Detection of MYD88 L265P Mutation in the Aqueous Humor of a Patient with Vitreoretinal Lymphoma for Disease Monitoring.
CONCLUSION: We present a case that demonstrates the possible utilization of serial testing for the MYD88 L265P mutation as a tool for monitoring disease course in vitreoretinal lymphoma. PMID: 32965155 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 24, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Adalimumab-associated Acquired Hemophilia in a Patient with Scleritis.
We present this case as an example of a rare, but potentially life-threatening, complication of adalimumab. PMID: 32966141 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 24, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

HIV-induced Retinitis.
CONCLUSION: Targeted antiviral treatment and secondary recurrence prophylaxis prevent vision loss of the retina prior to immune recovery. PMID: 32966142 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 24, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Clostridium Septicum Endogenous Endophthalmitis as the Initial Manifestation of Colorectal Carcinoma: Clinical Case Report and Literature Review.
CONCLUSIONS: iSystemic C. septicum infection without a traumatic cause has been associated with malignancy, although an initial presentation of endophthalmitis has rarely been reported. In cases of clostridial endogenous endophthalmitis, investigation for colorectal carcinoma is indicated. PMID: 32966149 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 24, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Effect of Fundus Fluorescein Angiography on Semiautomated Aqueous Flare Measurements.
CONCLUSIONS: Administration of fluorescein dye does not increase LFP values. The decrease in the LFP measurement following FFA may be attributed to dilation drops. PMID: 32966150 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 24, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Quantitative Analysis of the Iris Surface Smoothness by Anterior Segment Optical Coherence Tomography in Fuchs Uveitis.
CONCLUSION: Iris "smoothness index" can be used to quantitatively assess iris surface smoothness and may facilitate the diagnosis of subtle iris atrophic changes in eyes affected by FU especially in the absence of heterochromia. PMID: 32966151 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 24, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Bacillary Layer Detachment in Hyper-acute Stage of Acute Posterior Multifocal Placoid Pigment Epitheliopathy: A Case Series.
CONCLUSION: BLD appears in the acute stage of APMPPE and resolves rapidly within a week. PMID: 32966152 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 24, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Role of Prophylactic Vitrectomy in Acute Retinal Necrosis in Preventing Rhegmatogenous Retinal Detachment: Systematic Review and Meta-analysis.
Authors: Fan S, Lin D, Wang Y Abstract PURPOSE: To evaluate the effects of prophylactic vitrectomy for rhegmatogenous retinal detachment (RRD) risk and visual outcome in acute retinal necrosis (ARN). METHODS: A systematic search of online databases was performed for articles published between 1994 June and 2020 March. The main outcomes that were assessed by a fixed effects model were RRD risk and visual outcome during a follow up period. RESULTS: A total of 7 trials involving 265 eyes (121 prophylactic vitrectomy eyes vs 144 routine antiviral treatment eyes) were analyzed in this study. RRD risk significant...
Source: Ocular Immunology and Inflammation - September 24, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Letter to the Editor: Reply to Manuscript "Role of Ultra-widefield Imaging in Eales' Disease: A Case Series".
Letter to the Editor: Reply to Manuscript "Role of Ultra-widefield Imaging in Eales' Disease: A Case Series". Ocul Immunol Inflamm. 2020 Sep 23;:1 Authors: Banerjee M, Kumar V Abstract We read with interest the article "Role of Ultra-widefield Imaging in Eales' Disease: A Case Series" by Agarwal et al. We would like to congratulate the authors for their nice work and make few observations. We noted few discrepancies between the results and conclusions. Results revealed disease activity in 10/57 (17.5%), 20/57 (35%), and 29/57 (50.9%) patient visits with clinical examination, UWF Opt...
Source: Ocular Immunology and Inflammation - September 24, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Relapsing Thrombotic Thrombocytopenic Purpura (TTP) in a Patient Treated with Infliximab for Chronic Uveitis.
CONCLUSION: Relapsing thrombotic thrombocytopenic purpura can be a rare complication associated with infliximab. To our knowledge, it has not been reported in the literature to date. PMID: 32945712 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 20, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Clinical Characteristics, Management, and Factors Associated with Poor Visual Prognosis of Acute Retinal Necrosis.
Conclusions: The present study identified clinical characteristics and factors associated with poor visual prognosis of ARN. PMID: 32945715 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 20, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Ocular Tuberculosis: More than 'Of Mice and Men'.
Authors: Mitchell JL, Ganis L, Blacklock BT, Petrushkin H, Hope JC, Gunn-Moore DA Abstract Tuberculosis (TB), caused by infection with members of the Mycobacterium tuberculosis-complex, is one of the oldest known infectious disease entities, resulting in the death of millions of humans each year. It also results in a substantial degree of morbidity and mortality in animal species. Extrapulmonary TB is well recognized in humans, and the eye is one site that can be affected. Studies seeking to understand ocular TB have often relied on animal models; however, these have their limitations and may not truly reflect what...
Source: Ocular Immunology and Inflammation - September 20, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

SARS-CoV-2 Targeting the Retina: Host-virus Interaction and Possible Mechanisms of Viral Tropism.
CONCLUSIONS: Determining how SARS-CoV-2 can affect the retinal tissue is essential for the development of new therapeutic strategies and preventive measures, as well as for understanding the possible relationship between COVID-19 damage to the retina and to the brain. PMID: 32946292 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 20, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Creating a Health Utility Value for Birdshot Chorioretinopathy.
CONCLUSIONS: Of 28 patients with BCR, 11 would trade remaining life (mean 5.4 years), and 6 would take a risk of immediate death (mean 28% risk), in return for perfect vision in both eyes for the rest of their life. PMID: 32946293 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 20, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Choroidal Vascularity Index as a Potential Inflammatory Biomarker for Obsessive Compulsive Disorder.
CONCLUSION: Our findings suggest that systemic inflammation may play a role in the pathogenesis of OCD. PMID: 32946294 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 20, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Delayed-onset Bilateral Peripheral Posterior Interstitial Keratitis Associated with Epstein-Barr Virus-Induced Infectious Mononucleosis.
CONCLUSION: EBV-induced IM can cause bilateral peripheral interstitial keratitis with delayed onset. Progressive relapsing course of the keratitis can be observed. PMID: 32946296 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
Source: Ocular Immunology and Inflammation - September 20, 2020 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research