Is it SAFE to be grain-free?

Listen to critics of the Wheat Belly lifestyle and you’d think that, by banishing all things wheat and grains from your life, you will be excommunicated from your church, tossed out of your club, ostracized by friends and family, and suffer dire health consequences like heart disease and colon cancer. After all, they say that you are eliminating an entire food group and will be crippled by lack of fiber and nutrients. Worse, our focus on increasing our intake of fats and oils will get you a heart attack, three stents, or bypass surgery and you’ll be obliged to take Lipitor and Repatha for a lifetime. First of all, I challenge the notion that we are eliminating a food group. Recall that wheat and grains were added relatively recently (speaking anthropologically), around 12,000 years ago as einkorn wheat in the Fertile Crescent, millet in sub-Saharan Africa, rice from the swamps of Asia, and maize in Central America. I’ve previously discussed what happened to human health in each of those locales upon the consumption of these seeds of grasses: explosive tooth decay, a doubling of arthritis, iron deficiency, and other health effects. It means that we did NOT consume any seed of a grass plant for the preceding 3.5 million years. In other words, we have consumed wheat and grains for about 0.3% of our time on this planet and flourished. Just as we paid the price of acquiring zoonoses like tuberculosis and influenza upon the domestication of herbivorous ruminants, ...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle grain-free Weight Loss Source Type: blogs

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Publication date: Available online 21 August 2019Source: Journal of Ginseng ResearchAuthor(s): Moon Young Park, Se Jik Han, Donggerami Moon, Sangwoo Kwon, Jin-Woo Lee, Kyung Sook KimAbstractBackgroundRed ginseng contains components that can be used in skincare to delay the aging process, including microelements, vitamins, essential oils, and fatty acids. We investigated the effects of red ginseng treatment on skin elasticity by assessing cellular stiffness and measuring collagen protein synthesis.MethodsHuman dermal fibroblasts were treated with red ginseng, and the resulting changes in stiffness were investigated using at...
Source: Journal of Ginseng Research - Category: Complementary Medicine Source Type: research
ConclusionDifferentially expressed in tumors, PLA2G4A, PRKCB, PIK3R1, KDR, PLA2G1B and PTGS2 are potential therapeutic targets of Yupingfengsan in the treatment of LAD, and MAPK, VEGF and ErbB signaling pathways are involved.
Source: European Journal of Integrative Medicine - Category: Complementary Medicine Source Type: research
Publication date: Available online 22 August 2019Source: Journal of Cardiology CasesAuthor(s): Shohei Kataoka, Ken Kato, Hiroyuki Tanaka, Tamotsu TejimaAbstractIt is challenging to perform ablation of ventricular tachycardia (VT) from the left ventricle (LV) in patients without catheter access to the LV. A 50-year-old man was referred to our hospital for VT. He underwent mechanical aortic and mitral valve replacement for infective endocarditis and embolic myocardial infarction in the left ventricular inferior wall during a surgery. Anti-arrhythmia drugs (AADs) such as sotalol and bisoprolol were initiated and implantable c...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
Publication date: Available online 22 August 2019Source: Canadian Journal of CardiologyAuthor(s): Andrew S. Mackie, Anne Fournier, Lorna Swan, Ariane J. Marelli, Adrienne H. KovacsAbstractDramatic increases in survival to adulthood for individuals born with congenital heart disease (CHD) have led rise to a corresponding need to provide age- and developmentally-appropriate care across the lifespan. Healthcare transition is a multidimensional process that ideally begins in early adolescence in the pediatric setting and continues through young adulthood with input from both pediatric and adult CHD providers. Transition prepar...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 21 August 2019Source: Canadian Journal of CardiologyAuthor(s): Hajir Zohourian, Alexey V. Sorokin, Julia M. Ladna, Faraaz MushtaqAbstractBordetella hinzii’s route of transmission to human hosts and its pathogenicity remains unclear. Only a few cases have established this species as an opportunistic zoonotic disease. We introduce the first reported case of native aortic valve endocarditis presenting with fulminant aortic valve insufficiency which responded to conventional medical and surgical treatment. The patient did not have predisposing factors to this unusual infection. This cas...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 21 August 2019Source: Seminars in Cancer BiologyAuthor(s): Btissame El Hassouni, Carlotta Granchi, Andrea Vallés-Martí, I Gede Putu Supadmanaba, Giulia Bononi, Tiziano Tuccinardi, Niccola Funel, Connie R. Jimenez, Godefridus J. Peters, Elisa Giovannetti, Filippo MinutoloAbstractCancer metastasis to distant organs is initiated by tumor cells that disseminate from primary heterogeneous tumors. The subsequent growth and survival of tumor metastases depend on different metabolic changes, which constitute one of the enigmatic properties of tumor cells. Aerobic glycolysis, ‘...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 21 August 2019Source: Seminars in Cancer BiologyAuthor(s): Yue Zhao, Jiahui Li, Dai Li, Zhefang Wang, Jiangang Zhao, Xiaolin Wu, Qiye Sun, Peter Ping Lin, Patrick Plum, Menglong Zhou, Zhen Zhang, Hans Schlösser, Peter J. Nelson, Christiane J. BrunsAbstractMore than 70% of gastrointestinal (GI) cancers are diagnosed with metastases, leading to poor prognosis. For some cancer patients with limited sites of metastatic tumors, the term oligometastatic disease (OMD) has been coined as opposed to systemic polymetastasis (PMD) disease. Stephan Paget first described an organ-specific pattern...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 21 August 2019Source: Seminars in Cancer BiologyAuthor(s): Francesco Spagnolo, Andrea Boutros, Enrica Tanda, Paola QueiroloAbstractThe past 5 years have witnessed the results of many practice-changing studies that have dramatically improved the landscape of adjuvant therapy in patients with resected, high-risk melanoma. After a 20-year era of adjuvant interferon, the anti-CTLA-4 and anti-PD-1 immune-checkpoint inhibitors, and MAPK-directed targeted therapy brought a revolution into the adjuvant treatment of melanoma. These results came along with the practice-changing results of two large...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 21 August 2019Source: Seminars in Cancer BiologyAuthor(s): Carlos S. MorenoAbstractSOX4 is an essential developmental transcription factor that regulates stemness, differentiation, progenitor development, and multiple developmental pathways including PI3K, Wnt, and TGFβ signaling. The SOX4 gene is frequently amplified and overexpressed in over 20 types of malignancies, and multiple lines of evidence support that notion that SOX4 is an oncogene. Its overexpression is due to both gene amplification and to activation of PI3K, Wnt, and TGFβ pathways that SOX4 regulates. SOX4 interac...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
This article reviews endogenous- and exogenous-based stimulus-responsive drug delivery systems designed to overcome the limitations of conventional therapies. The article also summarizes the study of nanomaterials, including polymeric, gold, silver, magnetic, and quantum dot nanoparticles. Though an array of drug delivery systems has so far been proposed, there remain many challenges and concerns that should be addressed in order to fill the gaps in the field. Prominence is given to drug delivery systems that employ external- and internal-based stimuli and that are emerging as promising tools for cancer therapeutics in clinical settings.
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
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