Vitamin C for   5 days is associated with decreased hospital mortality in sepsis subgroups: a nationwide cohort study
Background: Previous randomized trials of vitamin C, hydrocortisone, and thiamine on sepsis were limited by short-term vitamin C administration, heterogeneous populations, and the failure to evaluate each component ' s effect. The purpose of this study was to determine whether vitamin C alone for ≥ 5 days or in combination with corticosteroids and/or thiamine was associated with decreased mortality across the sepsis population and subpopulation.; Methods: Nationwide population-based study conducted using the Korean National Health Insurance Service database. A total of 384,282 adult patien ts with sepsis who were admitte...
Source: Current Awareness Service for Health (CASH) - February 10, 2022 Category: Consumer Health News Source Type: news

Beyond the bundle: Clinical controversies in the management of sepsis in emergency medicine patients
Sepsis is a condition characterized by life-threatening organ dysfunction caused by a dysregulated host response to infection. The emergency department (ED) serves as a crucial entry point for patients presenting with sepsis. Given the heterogeneous presentation and high mortality rate associated with sepsis and septic shock, several clinical controversies have emerged in the management of sepsis. These include the use of novel therapeutic agents like angiotensin II, hydrocortisone, ascorbic acid, thiamine ( " HAT " ) therapy, and levosimendan, Additionally, controversies with current treatments in vasopressor dosing, and ...
Source: Current Awareness Service for Health (CASH) - January 11, 2022 Category: Consumer Health News Source Type: news

Adjunctive Thiamine in Critically Ill COVID-19 Patients Adjunctive Thiamine in Critically Ill COVID-19 Patients
What benefits might adjunctive thiamine therapy offer in the management of critically ill patients with COVID-19?Critical Care (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 5, 2021 Category: Consumer Health News Tags: Critical Care Journal Article Source Type: news

Thiamine combined with vitamin C in sepsis or septic shock: a systematic review and meta-analysis
Conclusions: Despite widespread enthusiasm for thiamine combined with vitamin C for sepsis and septic shock, we only found an association with reduced SOFA score and time of vasopressor use. There was no association with in-hospital mortality. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 9, 2021 Category: Consumer Health News Source Type: news

What Was Antarctic Explorer Ernest Shackleton's Mystery Illness?
THURSDAY, May 6, 2021 -- Famed Antarctic explorer Ernest Shackleton may have suffered from a deficiency of the nutrient thiamine, a condition known as beriberi, say researchers who claim they have cracked this nearly 120-year-old... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - May 6, 2021 Category: General Medicine Source Type: news

More Disappointing Results for Vitamin C, Thiamine and Hydrocortisone in Sepsis More Disappointing Results for Vitamin C, Thiamine and Hydrocortisone in Sepsis
Among critically ill patients with sepsis, treatment with hydrocortisone, vitamin C (ascorbic acid) and thiamine (HAT) did not improve outcome in the randomized controlled VICTAS trial.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - February 25, 2021 Category: Intensive Care Tags: Critical Care News Source Type: news

Effect of vitamin C, thiamine, and hydrocortisone on ventilator- and vasopressor-free Days in patients with sepsis
RCT (n=501) found no significant increase of ventilator- and vasopressor-free days with vitamin C, thiamine and hydrocortisone treatment vs placebo in critically ill patients with sepsis. Trial terminated early for administrative reasons and may have been underpowered. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 25, 2021 Category: Consumer Health News Source Type: news

The Campylobacter jejuni chemoreceptor Tlp10 has a bimodal ligand-binding domain and specificity for multiple classes of chemoeffectors
Campylobacter jejuni is a bacterial pathogen that is a common cause of enteritis in humans. We identified a previously uncharacterized type of sensory domain in the periplasmic region of the C. jejuni chemoreceptor Tlp10, termed the DAHL domain, that is predicted to have a bimodular helical architecture. Through two independent ligand-binding sites in this domain, Tlp10 responded to molecular aspartate, isoleucine, fumarate, malate, fucose, and mannose as attractants and to arginine, galactose, and thiamine as repellents. Tlp10 also recognized glycan ligands when present as terminal and intermediate residues of complex str...
Source: Signal Transduction Knowledge Environment - January 5, 2021 Category: Science Authors: Elgamoudi, B. A., Andrianova, E. P., Shewell, L. K., Day, C. J., King, R. M., Taha, , Rahman, H., Hartley-Tassell, L. E., Zhulin, I. B., Korolik, V. Tags: STKE Research Articles Source Type: news

Vitamin B1 Deficiency a Key Driver of Alcohol-Related Dementia? Vitamin B1 Deficiency a Key Driver of Alcohol-Related Dementia?
Individuals with alcohol use disorder have higher rates of dementia, and new research suggests that thiamine deficiency might play a role.Medscape Medical News (Source: Medscape Psychiatry Headlines)
Source: Medscape Psychiatry Headlines - September 17, 2020 Category: Psychiatry Tags: Psychiatry News Source Type: news

Vitamin B1 Deficiency a Key Driver of Dementia
Vitamin B1 Deficiency a Key Driver of Alcohol-Related Dementia? (Source: eMedicineHealth.com)
Source: eMedicineHealth.com - September 17, 2020 Category: General Medicine Source Type: news

Vitamin C and thiamine are associated with lower mortality in sepsis
BACKGROUND The efficacy of vitamin C (VitC) and thiamine (THMN) in patients admitted to the intensive care unit (ICU) with sepsis is unclear. The purpose of this study was to evaluate the effect of VitC and THMN on mortality and lactate clearance in ICU patients. We hypothesized that survival and lactate clearance would be improved when treated with thiamine and/or VitC. METHODS The Philips eICU database version 2.0 was queried for patients admitted to the ICU in 2014 to 2015 for 48 hours or longer and patients with sepsis and an elevated lactate of 2.0 mmol/L or greater. Subjects were categorized according to the receipt ...
Source: Current Awareness Service for Health (CASH) - September 3, 2020 Category: Consumer Health News Source Type: news

Your Body ’s First Responders
B vitamins aren’t glamourous… With the exception of vitamin B12, you may not be familiar with what the other B vitamins do. That can be a problem. B vitamins are critical nutrients for your immune system. And you may think you’re getting enough when you’re not. If you read ingredient labels, you often see B vitamins listed. The packaging may even say, “fortified with B vitamins.” But these are not really vitamins at all. They are “chemical copies” that have no real nutritional value. Today, I’ll show you how B vitamins help you beat infections and how to get the best s...
Source: Al Sears, MD Natural Remedies - May 6, 2020 Category: Complementary Medicine Authors: Dr.A.Sears Tags: Health Source Type: news

Treating sepsis with vitamin C, thiamine, and hydrocortisone: Exploring the quest for the magic elixir
The administration of ascorbic acid (vitamin C) alone or in combination with thiamine (vitamin B1) and corticosteroids (VCTS) has recently been hypothesized to improve hemodynamics, end-organ function, and may even increase survival in critically ill patients. This review aims to explore the current evidence and potential benefits and adverse effects of the VCTS regimen for the treatment of sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 26, 2020 Category: Consumer Health News Source Type: news

Amid Coronavirus outbreak, India mulls export ban on 12 essential drugs
An eight-member expert committee constituted by the government to assess availability of medicines in the country has suggested imposing export restrictions on 12 drugs including antibiotics like chloramphenicol, neomycin, metronidazole, azythromicin, clindamycin; vitamin B1, B2 and B6; as well as hormones like progesterone used during pregnancy and in menstrual related problems. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - February 16, 2020 Category: Pharmaceuticals Source Type: news

Pulses for a Sustainable Future
By Zoltán KálmánROME, Feb 10 2020 (IPS) Reducing poverty and inequalities, eliminating hunger and all forms of malnutrition and achieve food insecurity for all – these are some of the most important objectives of the Sustainable Development Goals. Still, the rate of poverty and inequalities is increasing and over 820 million people are going hungry. In addition, 2 billion people in the world are food insecure with great risk of malnutrition and poor health. This alarming situation is further aggravated by current trends such as the rate of population growth, impacts of climate change, loss of biodiversity, soil degrad...
Source: IPS Inter Press Service - Health - February 10, 2020 Category: International Medicine & Public Health Authors: Zoltan Kalman Tags: Climate Change Development & Aid Economy & Trade Environment Featured Food & Agriculture Global Headlines Health Human Rights Humanitarian Emergencies Inequity Natural Resources Poverty & SDGs TerraViva United Nations Source Type: news