Dietary Thiamine Has J-Shaped Association With Cognitive Decline
WEDNESDAY, Feb. 21, 2024 -- For older individuals, dietary thiamine intake has a J-shaped association with cognitive decline, with an inflection point of 0.68 mg/day, according to a study published online Feb. 20 in General Psychiatry. Chengzhang... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - February 21, 2024 Category: Pharmaceuticals Source Type: news

Dietary Thiamine Linked With Cognition
(MedPage Today) -- Dietary thiamine (vitamin B1) intake was linked with cognition in older adults, a longitudinal analysis in China suggested. Over a median follow-up of 5.9 years, cognitive decline risk was minimal at dietary thiamine intake... (Source: MedPage Today Psychiatry)
Source: MedPage Today Psychiatry - February 21, 2024 Category: Psychiatry Source Type: news

Just one bowl of cereal a day may raise risk of DEMENTIA - as study links cognitive decline to vitamin also in rice and oatmeal
A study published in General Psychiatry found a link between thiamine, which is commonly found in cereals, and cognitive decline in otherwise healthy people as they age. (Source: the Mail online | Health)
Source: the Mail online | Health - February 20, 2024 Category: Consumer Health News Source Type: news

Thiamine Offers Renal Protection in Septic Shock Thiamine Offers Renal Protection in Septic Shock
A post hoc analysis suggested that thiamine supplementation improved renal replacement therapy-free survival in patients with septic shock.Medscape Medical News (Source: Medscape Emergency Medicine Headlines)
Source: Medscape Emergency Medicine Headlines - February 19, 2024 Category: Emergency Medicine Tags: Emergency Medicine Source Type: news

When do Korsakoff patients justify immoral behaviors? The influence of premorbid delinquency and self-other perspectives in moral decision-making and moral reasoning - Vlot N, Postma A, Oudman E.
Korsakoff's syndrome (KS) is a chronic neuropsychiatric disorder caused by a vitamin B1 deficiency. KS is characterized by profound amnesia and often accompanied by poor executive functioning, decreased social-cognitive abilities, and difficulties in behav... (Source: SafetyLit)
Source: SafetyLit - October 16, 2023 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Pharma major Lupin launches injection to cure thiamine deficiency in US
Pharmaceutical company Lupin on Monday announced that it has launched its generic Thiamine Hydrochloride injection 200 mg/2 mL (100 mg/mL) multiple-dose vials used for treatment of thiamine deficiency in the US. The launch follows alliance partner Caplin Steriles receiving an approval for its ANDA (Abbreviated New Drug Application) from the US Food and Drug Administration (USFDA). (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - June 19, 2023 Category: Pharmaceuticals Source Type: news

Thiamine pharmaconutrition in sepsis: Monotherapy, combined therapy, or neither? Current evidence on safety and efficacy
Sepsis is a life-threatening condition characterized by multiorgan dysfunction due to an exaggerated host response to infection associated with a homeostatic failure. In sepsis, different interventions, aimed at improving clinical outcomes, have been tested over the past decades. Among these most recent strategies, intravenous high-dose micronutrients (vitamins and/or trace elements) have been investigated. According to current knowledge, sepsis is characterized by low thiamine levels, which are associated with illness severity, hyperlactatemia, and poor clinical outcomes. However, caution is needed about the clinical inte...
Source: Current Awareness Service for Health (CASH) - May 9, 2023 Category: Consumer Health News Source Type: news

Hydrocortisone, Vitamin C, and Thiamine in Septic Shock Hydrocortisone, Vitamin C, and Thiamine in Septic Shock
Does this early combination therapy prove to be a safe and effective treatment option for septic shock?Critical Care (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 28, 2022 Category: Consumer Health News Tags: Critical Care Journal Article Source Type: news

Vitamin C-based regimens for sepsis and septic shock: Systematic review and meta-analysis of randomized clinical trials
Conclusion: Further RCTs with higher methodological quality, an increased number of participants and assessing clinically relevant outcomes are needed to provide better decision-making guidance. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 27, 2022 Category: Consumer Health News Source Type: news

Unanswered questions on the use of hydrocortisone, ascorbic acid, and thiamine therapy in sepsis and septic shock
Conclusion: The utilization of HAT therapy for the management of sepsis and septic shock remains controversial. Hemodynamic benefits have been shown to be most pronounced when HAT therapy is initiated earlier. Future studies directed at earlier initiation may be necessary to confirm this theory. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 27, 2022 Category: Consumer Health News Source Type: news

Update on vitamin C administration in critical illness
Purpose of review: Several studies have recently explored the effects of intravenous vitamin C in sepsis. We aimed to summarize their findings to provide perspectives for future research. Recent findings: Sepsis trials examined 6 g/day of intravenous vitamin C with or without the thiamine and/or hydrocortisone compared with placebo or hydrocortisone. Network meta-analysis reported that intravenous vitamin C, thiamine, hydrocortisone, or combinations of these drugs was not proven to reduce long-term mortality. However, the component network meta-analysis suggested an association of high-dose (>6 g/day) and very-high dose v...
Source: Current Awareness Service for Health (CASH) - September 9, 2022 Category: Consumer Health News Source Type: news

Update on vitamin C administration in critical illness
Purpose of review: Several studies have recently explored the effects of intravenous vitamin C in sepsis. We aimed to summarize their findings to provide perspectives for future research. Recent findings: Sepsis trials examined 6 g/day of intravenous vitamin C with or without the thiamine and/or hydrocortisone compared with placebo or hydrocortisone. Network meta-analysis reported that intravenous vitamin C, thiamine, hydrocortisone, or combinations of these drugs was not proven to reduce long-term mortality. However, the component network meta-analysis suggested an association of high-dose (>6 g/day) and very-high dose vi...
Source: Current Awareness Service for Health (CASH) - August 15, 2022 Category: Consumer Health News Source Type: news

How Grief Upsets Your Gut Health
After the death of Caroline Rustigian’s mother earlier this year, her physical health took a tumble. “I stopped eating and couldn’t keep food down,” says Rustigian, a public relations consultant and podcaster in Laguna Beach, Calif. Desperate to feel better, Rustigian went to urgent care, where she was told that acid reflux was one cause of her tummy troubles. The doctor recommended medication, which eased her discomfort. However, the mother of two still didn’t feel like her old energetic self. “I was fatigued and just trying to get through each day,” she recalls. Finally, Rustigia...
Source: TIME: Health - July 1, 2022 Category: Consumer Health News Authors: Connie Chang and Juli Fraga Tags: Uncategorized freelance Gut health healthscienceclimate Source Type: news

Thiamine Hydrochloride (Thiamine Hydrochloride) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - April 27, 2022 Category: Drugs & Pharmacology Source Type: news

Vitamin C for   5 days is associated with decreased hospital mortality in sepsis subgroups: a nationwide cohort study
Background: Previous randomized trials of vitamin C, hydrocortisone, and thiamine on sepsis were limited by short-term vitamin C administration, heterogeneous populations, and the failure to evaluate each component ' s effect. The purpose of this study was to determine whether vitamin C alone for ≥ 5 days or in combination with corticosteroids and/or thiamine was associated with decreased mortality across the sepsis population and subpopulation.; Methods: Nationwide population-based study conducted using the Korean National Health Insurance Service database. A total of 384,282 adult patien ts with sepsis who were admitte...
Source: Current Awareness Service for Health (CASH) - February 10, 2022 Category: Consumer Health News Source Type: news