Hydrocortisone, Vitamin C, and Thiamine in Septic Shock Hydrocortisone, Vitamin C, and Thiamine in Septic Shock
Does this early combination therapy prove to be a safe and effective treatment option for septic shock?Critical Care (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 28, 2022 Category: Consumer Health News Tags: Critical Care Journal Article Source Type: news

Vitamin C-based regimens for sepsis and septic shock: Systematic review and meta-analysis of randomized clinical trials
Conclusion: Further RCTs with higher methodological quality, an increased number of participants and assessing clinically relevant outcomes are needed to provide better decision-making guidance. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 27, 2022 Category: Consumer Health News Source Type: news

Unanswered questions on the use of hydrocortisone, ascorbic acid, and thiamine therapy in sepsis and septic shock
Conclusion: The utilization of HAT therapy for the management of sepsis and septic shock remains controversial. Hemodynamic benefits have been shown to be most pronounced when HAT therapy is initiated earlier. Future studies directed at earlier initiation may be necessary to confirm this theory. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 27, 2022 Category: Consumer Health News Source Type: news

Update on vitamin C administration in critical illness
Purpose of review: Several studies have recently explored the effects of intravenous vitamin C in sepsis. We aimed to summarize their findings to provide perspectives for future research. Recent findings: Sepsis trials examined 6 g/day of intravenous vitamin C with or without the thiamine and/or hydrocortisone compared with placebo or hydrocortisone. Network meta-analysis reported that intravenous vitamin C, thiamine, hydrocortisone, or combinations of these drugs was not proven to reduce long-term mortality. However, the component network meta-analysis suggested an association of high-dose (>6 g/day) and very-high dose v...
Source: Current Awareness Service for Health (CASH) - September 9, 2022 Category: Consumer Health News Source Type: news

Update on vitamin C administration in critical illness
Purpose of review: Several studies have recently explored the effects of intravenous vitamin C in sepsis. We aimed to summarize their findings to provide perspectives for future research. Recent findings: Sepsis trials examined 6 g/day of intravenous vitamin C with or without the thiamine and/or hydrocortisone compared with placebo or hydrocortisone. Network meta-analysis reported that intravenous vitamin C, thiamine, hydrocortisone, or combinations of these drugs was not proven to reduce long-term mortality. However, the component network meta-analysis suggested an association of high-dose (>6 g/day) and very-high dose vi...
Source: Current Awareness Service for Health (CASH) - August 15, 2022 Category: Consumer Health News Source Type: news

How Grief Upsets Your Gut Health
After the death of Caroline Rustigian’s mother earlier this year, her physical health took a tumble. “I stopped eating and couldn’t keep food down,” says Rustigian, a public relations consultant and podcaster in Laguna Beach, Calif. Desperate to feel better, Rustigian went to urgent care, where she was told that acid reflux was one cause of her tummy troubles. The doctor recommended medication, which eased her discomfort. However, the mother of two still didn’t feel like her old energetic self. “I was fatigued and just trying to get through each day,” she recalls. Finally, Rustigia...
Source: TIME: Health - July 1, 2022 Category: Consumer Health News Authors: Connie Chang and Juli Fraga Tags: Uncategorized freelance Gut health healthscienceclimate Source Type: news

Thiamine Hydrochloride (Thiamine Hydrochloride) - new on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - April 27, 2022 Category: Drugs & Pharmacology Source Type: news

Vitamin C for   5 days is associated with decreased hospital mortality in sepsis subgroups: a nationwide cohort study
Background: Previous randomized trials of vitamin C, hydrocortisone, and thiamine on sepsis were limited by short-term vitamin C administration, heterogeneous populations, and the failure to evaluate each component ' s effect. The purpose of this study was to determine whether vitamin C alone for ≥ 5 days or in combination with corticosteroids and/or thiamine was associated with decreased mortality across the sepsis population and subpopulation.; Methods: Nationwide population-based study conducted using the Korean National Health Insurance Service database. A total of 384,282 adult patien ts with sepsis who were admitte...
Source: Current Awareness Service for Health (CASH) - February 10, 2022 Category: Consumer Health News Source Type: news

Beyond the bundle: Clinical controversies in the management of sepsis in emergency medicine patients
Sepsis is a condition characterized by life-threatening organ dysfunction caused by a dysregulated host response to infection. The emergency department (ED) serves as a crucial entry point for patients presenting with sepsis. Given the heterogeneous presentation and high mortality rate associated with sepsis and septic shock, several clinical controversies have emerged in the management of sepsis. These include the use of novel therapeutic agents like angiotensin II, hydrocortisone, ascorbic acid, thiamine ( " HAT " ) therapy, and levosimendan, Additionally, controversies with current treatments in vasopressor dosing, and ...
Source: Current Awareness Service for Health (CASH) - January 11, 2022 Category: Consumer Health News Source Type: news

Adjunctive Thiamine in Critically Ill COVID-19 Patients Adjunctive Thiamine in Critically Ill COVID-19 Patients
What benefits might adjunctive thiamine therapy offer in the management of critically ill patients with COVID-19?Critical Care (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 5, 2021 Category: Consumer Health News Tags: Critical Care Journal Article Source Type: news

Thiamine combined with vitamin C in sepsis or septic shock: a systematic review and meta-analysis
Conclusions: Despite widespread enthusiasm for thiamine combined with vitamin C for sepsis and septic shock, we only found an association with reduced SOFA score and time of vasopressor use. There was no association with in-hospital mortality. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 9, 2021 Category: Consumer Health News Source Type: news

What Was Antarctic Explorer Ernest Shackleton's Mystery Illness?
THURSDAY, May 6, 2021 -- Famed Antarctic explorer Ernest Shackleton may have suffered from a deficiency of the nutrient thiamine, a condition known as beriberi, say researchers who claim they have cracked this nearly 120-year-old... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - May 6, 2021 Category: General Medicine Source Type: news

More Disappointing Results for Vitamin C, Thiamine and Hydrocortisone in Sepsis More Disappointing Results for Vitamin C, Thiamine and Hydrocortisone in Sepsis
Among critically ill patients with sepsis, treatment with hydrocortisone, vitamin C (ascorbic acid) and thiamine (HAT) did not improve outcome in the randomized controlled VICTAS trial.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - February 25, 2021 Category: Intensive Care Tags: Critical Care News Source Type: news

Effect of vitamin C, thiamine, and hydrocortisone on ventilator- and vasopressor-free Days in patients with sepsis
RCT (n=501) found no significant increase of ventilator- and vasopressor-free days with vitamin C, thiamine and hydrocortisone treatment vs placebo in critically ill patients with sepsis. Trial terminated early for administrative reasons and may have been underpowered. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 25, 2021 Category: Consumer Health News Source Type: news

The Campylobacter jejuni chemoreceptor Tlp10 has a bimodal ligand-binding domain and specificity for multiple classes of chemoeffectors
Campylobacter jejuni is a bacterial pathogen that is a common cause of enteritis in humans. We identified a previously uncharacterized type of sensory domain in the periplasmic region of the C. jejuni chemoreceptor Tlp10, termed the DAHL domain, that is predicted to have a bimodular helical architecture. Through two independent ligand-binding sites in this domain, Tlp10 responded to molecular aspartate, isoleucine, fumarate, malate, fucose, and mannose as attractants and to arginine, galactose, and thiamine as repellents. Tlp10 also recognized glycan ligands when present as terminal and intermediate residues of complex str...
Source: Signal Transduction Knowledge Environment - January 5, 2021 Category: Science Authors: Elgamoudi, B. A., Andrianova, E. P., Shewell, L. K., Day, C. J., King, R. M., Taha, , Rahman, H., Hartley-Tassell, L. E., Zhulin, I. B., Korolik, V. Tags: STKE Research Articles Source Type: news