Potential Applications of Remote Limb Ischemic Conditioning for Chronic Cerebral Circulation Insufficiency

Conclusion Due to its long-term and often invisible course, CCCI has received less attention than acute cerebral ischemic stroke. However, without appropriate intervention, CCCI may lead to a variety of adverse events. Because the pathophysiological changes associated with CCCI are complex, pharmacological research in this area has been disappointing. Recent research suggests that RLIC, which is less invasive and more well-tolerated than drug treatment, can activate endogenous protective mechanisms during CCCI. In the present report, we reviewed studies related to CCCI (Table 1), as well as those related to stroke and stable coronary artery disease. The compiled evidence indicates that RLIC may exert neuroprotective effects during CCCI by attenuating the accumulation of amyloid-β in the CNS, regulating the inflammatory response, reducing glutamate excitotoxicity, attenuating apoptosis, regulating autophagy, improving endothelial cell function, and inducing the production of protective humoral factors. However, further research is required to verify whether these mechanisms contribute to the protective effects of RLIC. TABLE 1 Table 1. Studies related to CCCI. In addition, further studies are required to translate these experimental findings into clinical applications. Clinical studies have confirmed that RLIC can reduce the incidence of ischemic stroke in patients with symptomatic atherosclerotic stenosis (8). However, the impact of RLIC on cognitive im...
Source: Frontiers in Neurology - Category: Neurology Source Type: research

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Authors: Schulte C, Zeller T Abstract Cardiovascular (CV) risk assessment is based on the utilization of risk scores, enabling clinicians to estimate an individual's risk to develop CV pathologies and events. Such risk scores comprise classic CV risk factors such as smoking, diabetes, hypertension, and blood cholesterol levels. Recently, other CV biomarkers such as cardiac troponins have been suggested and evaluated as alternative biomarkers not only in the acute diagnostic setting of myocardial infarction, but also as markers for risk stratification in the general population. In this review, we summarize the curre...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
CONCLUSIONS: This meta-analysis found cardiovascular factors to be the main causes for both 30-day and 1‑year rehospitalization. Heart failure represented the most common cardiovascular event at both short-term and mid-term follow-up. Several baseline characteristics and procedure-related factors were deemed unfavorable predictors of readmission. Importantly, transfemoral access and female gender were associated with a lower risk of readmission. PMID: 31807789 [PubMed - as supplied by publisher]
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
Authors: Ding Y, Ding K, Yu K, Zou D, Yang H, He X, Mo W, Yu X, Ding X Abstract The 2010 American Society of Clinical Oncology guidelines have reduced the immunohistochemistry cut-off value for determining estrogen receptor b positivity from 10 to 1% of stained cells in breast cancer. In clinical practice, low-hormone receptor positive (low HR+) tumors are classified in the luminal subtype, although they exhibit aggressive features and poor prognosis. Information regarding the prognosis of patients with breast cancer following treatment with optimal endocrine therapy and neoadjuvant chemotherapy (NAC) is currently ...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Wang K, Huang R, Wu C, Li G, Zhao Z, Hu H, Liu Y Abstract Glioma is the most common type of malignant brain tumor, and is characterized by invasive growth and chemoradiotherapy resistance. The following Cancer Genome Atlas mutation subtypes were identified in initial high-grade gliomas and recurrent gliomas treated by chemoradiotherapy: Isocitrate dehydrogenase 1/2 (IDH1/2) mutation, epidermal growth factor receptor variant III (EGFRvIII) mutation, tumor protein P53 mutation, PTEN mutation, O6-methylguanine-DNA methyltransferase promoter methylation and telomerase reverse transcriptase (TERT) mutation. The...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
In conclusion, Abdominal DTs were prone to occur in patients with FAP with a history of abdominal surgery. Mutations in the APC, CTNNB1 and MUTYH genes were detected in patients with DTs. To the best of our knowledge, this is the first study of abdominal DT occurrence in patients with MUTYH-associated FAP. The prognosis of DT associated with FAP may be worse compared with that of sporadic DT. PMID: 31807167 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
In conclusion, CTD-2357A8.3 may be considered a promising diagnosis biomarker or a therapeutic target for the treatment of HNSCC. PMID: 31807160 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
CONCLUSIONS: CMV infection was not associated with impaired long-term prognosis after HT. PMID: 31806387 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
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Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 6 December 2019Source: Chinese Chemical LettersAuthor(s): Razium Ali Soomro, Sana Jawaid, Qizhen Zhu, Zaheer Abbas, Bin XuAbstractMXenes have emerged as versatile 2D materials that are already gaining paramount attention in the areas of energy, catalyst, electromagnetic shielding, and sensors. The unique surface chemistry, graphene-like morphology, high hydrophilicity, metal-like conductivity with redox capability identifies MXenes, as an ideal material for surface-related applications. This short review summarizes the most recent reports that discuss the potential application of MXenes a...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Publication date: Available online 6 December 2019Source: Chinese Chemical LettersAuthor(s): Yibo Chen, Jing-Feng Li, Pei-Yu Liao, Ying-Shan Zeng, Zhu Wang, Zhao-Qing LiuAbstractCuWO4, as an n-type oxide semiconductor with a bandgap of 2.2 eV, has stimulated enormous interest as a potential broad-spectrum-active photocatalyst for environmental pollution remediations. However, rapid charge recombination greatly hinders its practical applications. Herein, we present a cascaded electron transition pathway in a ternary heterostructure consisting of CdS quantum dots, carbon dots (CDs) and CuWO4 hollow spheres, which prov...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
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