miRNA-218 Targets Lipin-1 and Glucose Transporter Type 4 Genes in 3T3-L1 Cells Treated With Lopinavir/Ritonavir
Conclusion: 3T3-L1 cells, treated with LPV/RTV, show altered lipid content due to increased miRNA-218 levels, which affects lipin-1 mRNA. Moreover, increased miRNA-218 levels were inversely correlated with changes in GLUT-4 expression, which suggests a role for miRNA-218 in mediating the insulin resistance consequent to cART. Introduction Metabolic syndrome is a serious consequence of combined Antiretroviral Therapy (cART). HIV-associated metabolic syndrome is often accompanied by lipodystrophy (LS), the redistribution of body fat with loss of subcutaneous adipose tissue in face, limbs and buttocks, concomitant with fat accumulation in the trunk and in the intra-abdominal and inter-scapular regions. These morphological alterations are associated with metabolic dysfunctions including (i) insulin-resistance, (ii) hypercholesterolemia, and (iii) hypertriglyceridemia (Reinsch et al., 2012), all of which predispose the individual to increased risks of developing cardiovascular diseases as well as type II diabetes (Costa and Almeida, 2015). The causes of HIV-associated metabolic syndrome and LS are multiple, and poorly understood. HIV itself promotes LS, by generating a local inflammation of adipose tissue (Caron-Debarle et al., 2010). Similarly, the nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs) (Minami et al., 2011; Manente et al., 2012) used in cART, primarily contribute to the development of metabolic dysfunctions by promoting lipohyp...
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Authors: Kosińska B, Grabowski ML Abstract Balneotherapy experiences a sharp increase in popularity during recent years. The present paper gives a perspective on the therapeutic use of mineral baths in the town of Solec-Zdroj in southeastern Poland, an old time spa endowed with rich natural sulfurous water resources. Historical aspects of the formation and development of the spa are presented, along with the contemporary insights into the plausible mechanisms and benefits of sulfide treatment, not only in otherwise hardly treatable chronic skin disorders but also in a variety of disease processes in organ systems....
Authors: Long JD PMID: 31225773 [PubMed - as supplied by publisher]
In this study, we will use a mixed methods multi-center study design. In phase one, we will investigate the mental health literacy of PHC practitioners to identify areas in need of development. Based on the needs identified, we will develop and test a mobile health application to screen for common youth mental health problems in phase two. In phase three, we will implement and evaluate a tiered education and training program in the use of the m-health application. In the final phase, we will evaluate the acceptability and feasibility of the m-health application in PHC centres across South Africa and Zambia. Evidence sugges...
Kids these days are the “cautious generation,” the evidence shows.
Conclusion: In conclusion, GASL1 was downregulated in CHF. GASL1 overexpression may improve CHF by inhibiting cardiomyocyte apoptosis through the inactivation of TGF-β1. PMID: 31223316 [PubMed - in process]
This study summarizes the recent advances in our understanding of the sources, the anticancer mechanism, and the biosynthetic pathway of paclitaxel. With the advancement of biotechnology, improvements in endophytic fungal strains, and the use of recombination techniques and microbial fermentation engineering, the yield of extracted paclitaxel has increased significantly. Recently, paclitaxel has been found to play a large role in tumor immunity, and it has a great potential for use in many cancer treatments. PMID: 31223315 [PubMed - in process]
Our weekly series of diabetes humor at DiabetesMine features a features a cartoon by Jon Carter.
CONCLUSIONS: Extensive change in sexual behaviour occurred across eastern and southern Africa during the period of scale-up of antiretroviral therapy programmes. This includes increasing multiple and non-regular partnerships, but their potential effects on population-level sexual risks were often offset by parallel increases in condom use. Strengthening condom programmes and reintegrating communication about behavioural dimensions into combination prevention programmes could help countries to meet international targets for reductions in HIV incidence. PMID: 31225953 [PubMed - in process]
Conclusions. Patients in AF or SR undergoing CRT demonstrated distinct benefits from device implantation and from HIIT as an adjunctive therapeutic strategy. This suggests that both mainstay and adjunctive therapeutics may need to be managed differently in patients in AF and SR. PMID: 31221002 [PubMed - as supplied by publisher]
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