The Profile of Immunophenotype and Genotype Aberrations in Subsets of Pediatric T-Cell Acute Lymphoblastic Leukemia

The Profile of Immunophenotype and Genotype Aberrations in Subsets of Pediatric T-Cell Acute Lymphoblastic Leukemia Elda Pereira Noronha1†, Luísa Vieira Codeço Marques1†, Francianne Gomes Andrade1, Luiz Claudio Santos Thuler2, Eugênia Terra-Granado1, Maria S. Pombo-de-Oliveira1*† and the Brazilian Collaborative Study Group of Acute Leukemia‡ 1Pediatric Hematology-Oncology Program, Research Center, Instituto Nacional de Câncer, Rio de Janeiro, Brazil 2Clinical Research Division, Research Center, Instituto Nacional de Câncer, Rio de Janeiro, Brazil T-cell acute lymphoblastic leukemia (T-ALL) is a biologically heterogeneous malignancy, which reflects distinctive stages of T-cell differentiation arrest. We have revisited a cohort of pediatric T-ALL, in order to test if immunophenotypes associated with molecular alterations would predict the patient's outcome. Genetic mutations, translocations and copy number alterations were identified through Sanger sequencing, RT-PCR, FISH and multiplex ligation-dependent probe amplification (MLPA). We defined 8 immunophenotypic T-ALL subtypes through multiparametric flow cytometry: early T-cell precursor (ETP, n = 27), immature (n = 38), early cortical (n = 15), cortical (n = 50), late cortical (n = 53), CD4/CD8 double negative mature (n = 31), double positive mature (n = 35) and simple positive mature (n = 31) T-ALL. Deletions (del) or amplifications (amp) in at lea...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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Publication date: April 2020Source: Fish &Shellfish Immunology, Volume 99Author(s): José María García Beltrán, Daniel González Silvera, Cristóbal Espinosa Ruiz, Vittorio Campo, Latifeh Chupani, Caterina Faggio, María Ángeles EstebanAbstractOriganum sp. is a very common genus of aromatic plants worldwide distributed around the Mediterranean area and O. vulgare (oregano) is the most important species of this genus throughout the world. Due the known medicinal properties of oregano, the effect of diets enriched with 0% (control), 0.5% and 1% oregano leaves powder was...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: April 2020Source: Fish &Shellfish Immunology, Volume 99Author(s): Shujing Liu, Weilin Wang, Wenjing Ge, Xiaojing Lv, Zirong Han, Yinan Li, Lingling Wang, Linsheng SongAbstractThe homeostasis of immune cells during immune response is vital for hosts to defend against invaders. Activating transcription factor 6 (ATF6) is an important transcription factor in the unfolded protein response (UPR) to maintaining cellular homeostasis. In the present study, one ATF6 homologue was identified from Pacific oyster Crassostrea gigas (designated as CgATF6β). The full length cDNA of CgATF6β was of 2645 bp w...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
In this study, we have identified and compared the expression pattern of European sea bass and gilthead seabream NKL and evaluated its transcription in different tissues and its regulation in head-kidney leucocyte (HKLs) stimulated in vitro with different immunostimulants, under CMC response and upon an in vivo infection with NNV. Our results showed that nkl transcription is highly expressed in spleen, thymus and skin with species-specific differences. Interestingly, the expression pattern in both species was very different upon treatment. While sea bass nkl transcription was increased in HKLs by the T mitogen phytohemaggl...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Dalton Trans., 2020, Accepted Manuscript DOI: 10.1039/D0DT00180E, PaperWei-Wei Qin, Zheng-Yin Pan, Daihong Cai, Yi Li, Liang He The combination of chemotherapy and photodynamic therapy in an iridium-based molecular compound is less reported. Herein, two iridium complexes (IrC1 and IrC2) with -carboline alkaloid ligands were designed and synthesized.... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - Category: Chemistry Authors: Source Type: research
AbstractThree BODIPY ‐peptide conjugates designed to target the epidermal growth factor receptor (EGFR) at the extracellular domain were synthesized and their specificity for binding to EGFR was investigated. Peptide sequences containing seven amino acids, GLARLLT (2) and KLARLLT (3), and 13 amino acids, GYHWYGYTPQNVI (4), were conjugated to carboxyl BODIPY dye (1) by amide bond formation in up to 73% yields. The BODIPY ‐peptide conjugates and their “parent” peptides were determined to bind to EGFR experimentally using SPR analysis, and were further investigated using computational methods (AUTODOCK). Resul...
Source: Photochemistry and Photobiology - Category: Science Authors: Tags: SPECIAL ISSUE RESEARCH ARTICLE Source Type: research
Publication date: August 2020Source: Journal of Neurolinguistics, Volume 55Author(s): Evelyn Bosma, Leticia PablosAbstractWhile switching costs in production have been explained in terms of top-down cognitive control, researchers do not agree whether switching costs in comprehension should be interpreted in the same way. Within the BIA + model, it has been claimed that the comprehension of code-switches can be explained sufficiently in terms of bottom-up activation of lexical representations. In the current electrophysiological study, L1 speakers of Dutch with high proficiency in L2 English (n = 63) com...
Source: Journal of Neurolinguistics - Category: Speech-Language Pathology Source Type: research
AbstractWe study interdependent risks in security, and shed light on the economic and policy implications of increasing security interdependence in presence of reactive attackers. We investigate the impact of potential public policy arrangements on the security of a group of interdependent organizations, namely, airports. Focusing on security expenditures and costs to society, as assessed by a social planner, to individual airports and to attackers, we first develop a game ‐theoretic framework, and derive explicit Nash equilibrium and socially optimal solutions in the airports network. We then conduct numerical experimen...
Source: Risk Analysis - Category: International Medicine & Public Health Authors: Tags: Original Research Article Source Type: research
Publication date: February 2020Source: Learning and Individual Differences, Volume 78Author(s): Catherine Gunzenhauser, Henrik SaalbachAbstractSelf-regulation is crucial for acquiring mathematical competencies in elementary school. The present longitudinal study aimed at investigating determinants and consequences of domain-specific self-regulation with regard to the mathematics domain.Participants were N = 257 third graders (MAge = 8.59 years, SD = 0.57 years; 51% girls) from East Germany as well as children's mathematics teachers. The project included two time points (6-month interval). Children's self-re...
Source: Learning and Individual Differences - Category: Psychiatry & Psychology Source Type: research
Manchester City ’s fortunes changed dramatically with the takeover by Sheikh Mansour of Abu Dhabi. But after years of success, Europe’s governing body has banned the club from its most prestigious tournament, the Champions League. David Conn explains why. Plus: Alok Jha on the ethics of gene editingIt was deep into injury time in the final match of the 2011-12 season and Manchester City needed a goal to win the Premier League with just seconds remaining. The Argentinian striker Sergio Ag üero jinked past a QPR defender and smashed the ball into the net, sending the crowd into raptures and securing the club...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Manchester City Football UK news Gene editing Genetics Science Source Type: news
Contributors : Samuel Jacques ; Almer M van der Sloot ; Caroline Huard ; Jasmin Coulombe-Huntington ; Sarah Tsao ; Sylvain Tollis ; Thierry Bertomeu ; Elizabeth J Culp ; Daniel Pallant ; Michael A Cook ; Eric Bonneil ; Pierre Thibault ; Gerard D Wright ; Michael TyersSeries Type : OtherOrganism : Homo sapiensSystematic genetic interaction profiles can reveal the mechanism-of-action of bioactivecompounds. The imipridone ONC201, which is currently in cancer clinical trials, has beenascribed a variety of different targets. To investigate the genetic dependencies of imipridoneaction, we screened a genome-wide CRISPR knockout l...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
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