Endometrial Tumor Microenvironment Alters Human NK Cell Recruitment, and Resident NK Cell Phenotype and Function

Endometrial Tumor Microenvironment Alters Human NK Cell Recruitment, and Resident NK Cell Phenotype and Function Clara Degos1, Mellie Heinemann2, Julien Barrou2, Nicolas Boucherit1, Eric Lambaudie2, Ariel Savina3†, Laurent Gorvel1* and Daniel Olive1* 1Tumor Immunology Team, IBISA Immunomonitoring Platform, Cancer Research Center of Marseillle, INSERM U1068, CNRS U7258, Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France 2Department of Surgical Oncology 2, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Aix-Marseille University, Marseille, France 3Institut Roche, Boulogne Billancourt, France Endometrial Cancer is the most common cancer in the female genital tract in developed countries, and with its increasing incidence due to risk factors such as aging and obesity tends to become a public health issue. However, its immune environment has been less characterized than in other tumors such as breast cancers. NK cells are cytotoxic innate lymphoid cells that are considered as a major anti-tumoral effector cell type which function is drastically altered in tumors which participates to tumor progression. Here we characterize tumor NK cells both phenotypically and functionally in the tumor microenvironment of endometrial cancer. For that, we gathered endometrial tumors, tumor adjacent healthy tissue, blood from matching patients and healthy donor blood to perform comparative analysis of NK cells. First we found that NK cells were impoverished in the...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

Related Links:

From the European Congress of Virology in Rotterdam, Vincent and local co-host Ben Berkhout speak with Ron Fouchier, Rosina Girones, and Marie-Paule Kieny about their careers and their work on influenza virus, environmental virology, and developing an Ebola virus vaccine during an epidemic. Click arrow to play Download TWiV 557 (41 MB .mp3, 67 min) Subscribe (free): iTunes, Google […]
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology antigenic drift ebola virus environmental virology epidemic global health H2N2 influenza virus pandemic vaccine viral viruses viruses in water Source Type: blogs
CONCLUSION: This study confirmed published results that labour progresses more slowly as maternal BMI increases. The study was performed in a centre with a specialized BMI pregnancy clinic; thus weight gain adherence, awareness of labour differences, and patient counselling may have contributed to low Caesarean section rates. Obstetric care providers should consider differences in maternal BMI in labour progression before undertaking a potentially premature Caesarean birth, especially in primiparas. PMID: 31324481 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
Publication date: December 2019Source: Protein Expression and Purification, Volume 164Author(s): Elisabeth Graeber, Volodymyr M. KorkhovAbstractThe translocator protein TSPO is in an important diagnostic and therapeutic target in a range of pathologies, including neuroinflammation and cancer. Despite the availability of several structures of TSPO homologues, our understanding of the molecular determinants that govern high-affinity interactions of TSPO with its ligands is incomplete. Here, in order to decipher the key structural elements of TSPO responsible for interactions with its ligands, we designed a panel of chimeric ...
Source: Protein Expression and Purification - Category: Biochemistry Source Type: research
This is a guest post from one of our patients. She is 32 and recently froze her eggs at Malpani Infertility ClinicOur 20 ’s and early 30's may be theeasiest time to have a baby but it's not always the best time - for a lot of good reasons. We are at the top of our career and want to grow professionally; we want to prepare emotionally and financially to be parents ; and we are unwilling to settle for Mr. RightNow instead of Mr. Right.The problem is that the biological clock is ticking on - and we can hear it loud and clear ! The good news is that with a little medical help , we can freeze time , to plan for the future...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
ConclusionLicensed drivers with ASD were found to allocate visual attention differently compared to licensed drivers without ASD. Poor scanning patterns with an over-focus on the road ahead and less scanning of the road side and periphery may possibly result in unsafe driving. However, risk-taking behaviour was not prevalent in these drivers. Effective visual scanning strategies could be incorporated in the driver training of individuals with ASD.
Source: Journal of Transport and Health - Category: Occupational Health Source Type: research
Publication date: Available online 21 July 2019Source: European UrologyAuthor(s): Marshall Strother, Alexander Kutikov
Source: European Urology - Category: Urology & Nephrology Source Type: research
I’ve scanned through and haven’t found a post that seems to fully answer my question. I have about $150,00 in student loans left, all of which are federal. When I first graduated I picked the 25 year extended payment plan. I decided not to do IBR because the payments were about the same and I assumed my income would increase. Since this will now be year 3 without a raise or bonus, does it make sense to backtrack and sign up for IBR? I picked the plan I did with the intent to pay extra and... IBR? Loan advice?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pharmacy Source Type: forums
Source: ClinicoEconomics and Outcomes Research - Category: Health Management Tags: ClinicoEconomics and Outcomes Research Source Type: research
Source: ClinicoEconomics and Outcomes Research - Category: Health Management Tags: ClinicoEconomics and Outcomes Research Source Type: research
young female, known to have a metastatic breast cancer, since 5 years. In 2017, she developed secondary lesions in the brain with positive CSF. She receives 30Gy/10 fr whole brain radiation, with intra-thecal chemotherapy. A month ago, she developed gait disturbances with blurred speech an hemifacial paresia. Brain MRI showed a solitary secondary lesion, 1.5 cm involving the left middle cerebral peduncle with extensive edema. No signs of meningeal disease. Pet CT : NED outside the brain... SRS for BS lesion: what dose?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Radiation Oncology Source Type: forums
More News: Academia | Adenocarcinoma | Allergy & Immunology | Arthritis | AstraZeneca | Biology | Breast Cancer | Breast Carcinoma | Cancer | Cancer & Oncology | Cancer of the Uterus | Cancer Vaccines | Carcinoma | Carcinosarcoma | Cervical Cancer | Chemistry | Chemotherapy | Clear Cell Carcinoma | Clinical Trials | Colon Cancer | Colorectal Cancer | CT Scan | Eating Disorders & Weight Management | Endometrial Cancer | Endometrioid Carcinoma | Environmental Health | Epidemiology | Erbitux | Eye Cancers | France Health | Funding | Gastric (Stomach) Cancer | Gastroenterology | Genetics | Grants | Hepatocellular Carcinoma | Hormones | Huntington's Disease | Immunotherapy | International Medicine & Public Health | Italy Health | Liver | Liver Cancer | Lung Cancer | Medical Ethics | Melanoma | Men | Myocarditis | Obesity | OBGYN | Opthalmology | Ovarian Cancer | Ovaries | Pathology | Penicillin | PET Scan | Pharmaceuticals | Prostate Cancer | Reproduction Medicine | Rheumatology | Salaries | Serous Carcinoma | Skin Cancer | Spain Health | Statistics | Study | Urology & Nephrology | Uveal Melanoma | Vaccines