Endometrial Tumor Microenvironment Alters Human NK Cell Recruitment, and Resident NK Cell Phenotype and Function

Endometrial Tumor Microenvironment Alters Human NK Cell Recruitment, and Resident NK Cell Phenotype and Function Clara Degos1, Mellie Heinemann2, Julien Barrou2, Nicolas Boucherit1, Eric Lambaudie2, Ariel Savina3†, Laurent Gorvel1* and Daniel Olive1* 1Tumor Immunology Team, IBISA Immunomonitoring Platform, Cancer Research Center of Marseillle, INSERM U1068, CNRS U7258, Institut Paoli-Calmettes, Aix-Marseille University, Marseille, France 2Department of Surgical Oncology 2, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Aix-Marseille University, Marseille, France 3Institut Roche, Boulogne Billancourt, France Endometrial Cancer is the most common cancer in the female genital tract in developed countries, and with its increasing incidence due to risk factors such as aging and obesity tends to become a public health issue. However, its immune environment has been less characterized than in other tumors such as breast cancers. NK cells are cytotoxic innate lymphoid cells that are considered as a major anti-tumoral effector cell type which function is drastically altered in tumors which participates to tumor progression. Here we characterize tumor NK cells both phenotypically and functionally in the tumor microenvironment of endometrial cancer. For that, we gathered endometrial tumors, tumor adjacent healthy tissue, blood from matching patients and healthy donor blood to perform comparative analysis of NK cells. First we found that NK cells were impoverished in the...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

Related Links:

A prospective study of a urine and plasma biomarker test for the prediction of gleason ≥3 + 4 prostate cancer in a mixed cohort. Scand J Urol. 2020 Jul 01;:1-5 Authors: Poulsen MH, Feddersen S, Albitar M, Poulsen CA, Lund M, Pedersen TB, Mortensen MA, Lund L Abstract Purpose: Definitive diagnosis of prostate cancer is based on biopsies, a procedure associated with side-effects. The use of biomarkers in blood and urine could potentially help clinicians select patients for whom biopsies are needed. The aim of the study was to test a new urine and plasma biomarker test in detecting medium...
Source: Scandinavian Journal of Urology - Category: Urology & Nephrology Tags: Scand J Urol Source Type: research
Conclusions: In this study, the conversion of maintenance immunosuppression from calcineurin inhibitors to mTOR inhibitors for clinical indications did appear to reduce the incidence of NMSC in kidney and liver transplant recipients. PMID: 32605413 [PubMed - in process]
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Publication date: Available online 1 July 2020Source: Journal of EthnopharmacologyAuthor(s): Huan Zhou, Li-xiang Fu, Li Li, Yan-yan Chen, Hong-qing Zhu, Jin-ling Zhou, Mei-xian Lv, Ri-zhi Gan, Xuan-xuan Zhang, Gang Liang
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusions: There was a high prevalence of pain and intense pain in individuals with severe obesity and an association with clinical variables, the degree of obesity, and sedentary lifestyle. PMID: 32606269 [PubMed]
Source: Korean Journal of Pain - Category: Anesthesiology Tags: Korean J Pain Source Type: research
This article reviews the brief history, efficacy, and safety of the two vaccines and discusses the advantage of RZV over LZV based on the available literature. PMID: 32606264 [PubMed]
Source: Korean Journal of Pain - Category: Anesthesiology Tags: Korean J Pain Source Type: research
Response to comment on: Parental opinions towards the "No Jab, No Pay" policy in Australia. Vaccine. 2020 Jul 14;38(33):5090 Authors: Trent MJ, MacIntyre CR PMID: 32605725 [PubMed - in process]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
PMID: 32605724 [PubMed - in process]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Gamma linolenic acid suppresses hypoxia-induced gastric cancer cell growth and epithelial-mesenchymal transition by inhibiting the Wnt/β-catenin signaling pathway. Folia Histochem Cytobiol. 2020 Jul 01;: Authors: Wang Y, Shi J, Gong L Abstract INTRODUCTION: Gastric cancer is one of the most common malignancies in China and the fifth most common cancer in the world. Gamma linolenic acid (GLA) was reported to have anti-inflammatory and anti-cancer effects. The purpose of this research was to investigate the effect and mechanism of GLA on gastric cancer cell growth under hypoxic conditions. MATER...
Source: Folia Histochemica et Cytobiologica - Category: Cytology Tags: Folia Histochem Cytobiol Source Type: research
In this study, we describe a three-generation Italian family showing the segregation of an interrupted DMPK allele within the premutation range. TP-PCR with primers complementary to CCG repetitions and direct sequencing allow us to identify a hetero-triplet (CTG)6(CCGCTG)15(CTG)5 repeat structure. The haplotype analysis demonstrated that this variant allele is associated with the European founder DM1 haplotype. The pyrosequencing analysis of the CpG islands contained in the flanking regions of the CTG array, did not show the presence of a cis effect of the CCG interruptions on the methylation profile of the DM1 locus. The ...
Source: Acta Myologica - Category: Neurology Tags: Acta Myol Source Type: research
Conclusion. This evaluation shows improvements in socioeconomic and health economic parameters on GLM treatment. PMID: 32609555 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
More News: Academia | Adenocarcinoma | Allergy & Immunology | Arthritis | AstraZeneca | Biology | Breast Cancer | Breast Carcinoma | Cancer | Cancer & Oncology | Cancer of the Uterus | Cancer Vaccines | Carcinoma | Carcinosarcoma | Cervical Cancer | Chemistry | Chemotherapy | Clear Cell Carcinoma | Clinical Trials | Colon Cancer | Colorectal Cancer | CT Scan | Eating Disorders & Weight Management | Endometrial Cancer | Endometrioid Carcinoma | Environmental Health | Epidemiology | Erbitux | Eye Cancers | France Health | Funding | Gastric (Stomach) Cancer | Gastroenterology | Genetics | Grants | Hepatocellular Carcinoma | Hormones | Huntington's Disease | Immunotherapy | International Medicine & Public Health | Italy Health | Liver | Liver Cancer | Lung Cancer | Medical Ethics | Melanoma | Men | Myocarditis | Obesity | OBGYN | Opthalmology | Ovarian Cancer | Ovaries | Pathology | Penicillin | PET Scan | Pharmaceuticals | Prostate Cancer | Reproduction Medicine | Rheumatology | Salaries | Serous Carcinoma | Skin Cancer | Spain Health | Statistics | Study | Urology & Nephrology | Uveal Melanoma | Vaccines