CD4+Foxp3+T Regulatory Cells Promote Transplantation Tolerance by Modulating Effector CD4+ T Cells in a Neuropilin-1-Dependent Manner

CD4+Foxp3+T Regulatory Cells Promote Transplantation Tolerance by Modulating Effector CD4+ T Cells in a Neuropilin-1-Dependent Manner Mauricio Campos-Mora1,2, Pamina Contreras-Kallens1, Felipe Gálvez-Jirón1, Masyelly Rojas1, Carolina Rojas3, Aarón Refisch1, Oscar Cerda2,4 and Karina Pino-Lagos1* 1Centro de Investigación Biomédica, Facultad de Medicina, Universidad de los Andes, Las Condes, Chile 2Programa de Biología Celular y Molecular, Facultad de Medicina, Instituto de Ciencias Biomédicas (ICBM), Universidad de Chile, Santiago, Chile 3Facultad de Odontología, Universidad de Chile, Santiago, Chile 4Millennium Nucleus of Ion Channel Associated Diseases (MiNICAD), Universidad de Chile, Santiago, Chile Several mechanisms of immune suppression have been attributed to Foxp3+ T regulatory cells (Treg) including modulation of target cells via inhibition of cell proliferation, alteration of cytokine secretion, and modification of cell phenotype, among others. Neuropilin-1 (Nrp1), a co-receptor protein highly expressed on Treg cells has been involved in tolerance-mediated responses, driving tumor growth and transplant acceptance. Here, we extend our previous findings showing that, despite expressing Foxp3, Nrp1KO Treg cells have deficient suppressive function in vitro in a contact-independent manner. In vivo, the presence of Nrp1 on Treg cells is required for driving long-term transplant tolerance. Interestingly, Nr...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research

Related Links:

Publication date: Available online 30 June 2020Source: Artificial Intelligence in MedicineAuthor(s): Danqing Hu, Shaolei Li, Zhengxing Huang, Nan Wu, Xudong Lu
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research
Authors: Koczwara B PMID: 32596806 [PubMed - as supplied by publisher]
Source: Medical Journal of Australia - Category: General Medicine Tags: Med J Aust Source Type: research
Using laser excitation, expression microdissection (xMD) can selectively heat cancer cells targeted via immunohistochemical staining ...
Source: Applied Optics - Category: Physics Authors: Source Type: research
CONCLUSIONS: The results of this study suggest that diet drinks have no adverse effect on teeth among US children. Additional well-designed longitudinal studies should be conducted to establish the effect of diet drinks on caries when consumed during childhood. PRACTICAL IMPLICATIONS: Although this study did not show an association between caries and diet drinks, dental practitioners should be cautious about recommending these drinks, as they have been linked to systemic diseases. In addition, the American Academy of Pediatrics and National Academy of Medicine do not recommend that children consume these beverages. ...
Source: Journal of the American Dental Association - Category: Dentistry Tags: J Am Dent Assoc Source Type: research
Authors: Stevenson RB PMID: 32593344 [PubMed - in process]
Source: Journal of the American Dental Association - Category: Dentistry Tags: J Am Dent Assoc Source Type: research
CONCLUSION: Traditional techniques, like radiotherapy (RT) show decent results, although they cannot spare 100% the healthy tissues neighboring with the cancer ones. Targeted therapies, such as proton and photodynamic therapy (PT and PDT, respectively) present adequate outcomes, even though each one has its own drawbacks. In order to overcome these limitations, the combination of therapeutic modalities has been proposed and has already been showing promising results. At the same time, the recent advances in nanotechnology in the form of nanoparticles enhance cancer therapy, making multimodal treatments worthy of exploring ...
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
Conclusion: No statistically significant radiation associations were observed among 114,270 nuclear weapons test participants followed for up to 65 y. The 95% confidence limits were narrow and exclude mortality risks per unit dose that are two to four times those reported in other investigations. Significantly elevated SMRs were seen for mesothelioma and asbestosis, attributed to asbestos exposure aboard ships. PMID: 32602389 [PubMed - as supplied by publisher]
Source: International Journal of Radiation Biology - Category: Radiology Tags: Int J Radiat Biol Source Type: research
In this report, we will present the symptoms and manifestations of this disease to reduce late detection and exacerbating factors. The patient was a three-year-old girl from Tehran, Iran who had ascites and hepatomegaly. When she was 9 month-old, she was diagnosed as autoimmune hepatitis after liver biopsy and she was treated with immunosuppressive drugs (Azathioprine, prednisolone, and cyclosporine) for 22 months, but later she suffered from fever, pancytopenia, and hepatosplenomegaly. Then a bone marrow biopsy was done for her. There was a large amount of Leishman body in her bone marrow and treatment for Kala-azar was s...
Source: Iranian Journal of Parasitology - Category: Parasitology Tags: Iran J Parasitol Source Type: research
Conclusion: Performing specialized tests to diagnose toxoplasma infection before starting treatment, in immunodeficiency patients who undergo chemotherapy, is necessary; therefore, these tests should be considered in therapeutic protocols. PMID: 32595708 [PubMed]
Source: Iranian Journal of Parasitology - Category: Parasitology Tags: Iran J Parasitol Source Type: research
CONCLUSION: The participants who received a structured IBT intervention lost significantly more weight after two months, compared to those who received weekly informational emails regarding weight loss. Internet-based behavioral therapy programs may have the potential to serve as a low-cost alternative for obese patients. PMID: 32594478 [PubMed - in process]
Source: Turkish Journal of Psychiatry - Category: Psychiatry Authors: Tags: Turk Psikiyatri Derg Source Type: research
More News: Allergy & Immunology | Arthritis | Autoimmune Disease | Biology | Biotechnology | Bone Graft | Brain | Cancer | Cancer & Oncology | Cardiology | Cardiovascular | Cardiovascular & Thoracic Surgery | Cervical Cancer | Chile Health | Chronic Leukemia | Chronic Lymphocytic Leukemia | Clinical Trials | Cytology | Diabetes | Diabetes Type 1 | Economy | Endocrinology | Environmental Health | Funding | Genetics | Graduation | Grants | Heart | Ireland Health | Kidney Transplant | Kidney Transplantation | Laboratory Medicine | Leukemia | Medical Ethics | Melanoma | Men | Milk | Molecular Biology | Neurology | Neuroscience | Neurosurgery | Orthopaedics | Penicillin | Rheumatology | Science | Skin | Skin Biopsy | Skin Cancer | Skin Graft | Sodium | Statistics | Students | Study | Transplant Surgery | Transplants | Universities & Medical Training | Urology & Nephrology