Is Aberrant Reno-Renal Reflex Control of Blood Pressure a Contributor to Chronic Intermittent Hypoxia-Induced Hypertension?

Is Aberrant Reno-Renal Reflex Control of Blood Pressure a Contributor to Chronic Intermittent Hypoxia-Induced Hypertension? Sara AlMarabeh, Mohammed H. Abdulla and Ken D. O'Halloran* Department of Physiology, School of Medicine, College of Medicine and Health, University College Cork, Cork, Ireland Renal sensory nerves are important in the regulation of body fluid and electrolyte homeostasis, and blood pressure. Activation of renal mechanoreceptor afferents triggers a negative feedback reno-renal reflex that leads to the inhibition of sympathetic nervous outflow. Conversely, activation of renal chemoreceptor afferents elicits reflex sympathoexcitation. Dysregulation of reno-renal reflexes by suppression of the inhibitory reflex and/or activation of the excitatory reflex impairs blood pressure control, predisposing to hypertension. Obstructive sleep apnoea syndrome (OSAS) is causally related to hypertension. Renal denervation in patients with OSAS or in experimental models of chronic intermittent hypoxia (CIH), a cardinal feature of OSAS due to recurrent apnoeas (pauses in breathing), results in a decrease in circulating norepinephrine levels and attenuation of hypertension. The mechanism of the beneficial effect of renal denervation on blood pressure control in models of CIH and OSAS is not fully understood, since renal denervation interrupts renal afferent signaling to the brain and sympathetic efferent signals to the kidneys. Herein, we consider the current...
Source: Frontiers in Physiology - Category: Physiology Source Type: research

Related Links:

Publication date: Available online 28 March 2020Source: Materials Today: ProceedingsAuthor(s): S. Godwin Barnabas, S. Valai Ganesh, V. Sivakumar, P. Muthukumar, A. Dhinesh Raja, K. Hariharan
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Publication date: Available online 28 March 2020Source: Materials Today: ProceedingsAuthor(s): Rasmita Biswal, Vineeta Shukla, S. Janakiraman, Sudipto Ghosh, Venimadhav Adyam
Source: Materials Today: Proceedings - Category: Materials Science Source Type: research
Publication date: Available online 28 March 2020Source: Journal of Clinical NeuroscienceAuthor(s): Akemi Hioka, Yoshiteru Tada, Keiko Kitazato, Naoki Akazawa, Yasushi Takagi, Shinji Nagahiro
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Authors: Su Y, Pu Y, Zhao Z, Yang X Abstract Effects of combined epidural anesthesia on the cognitive function, inflammation and stress response in the elderly liver cancer patients undergoing surgery were explored. Elderly liver cancer patients (n=100) undergoing surgery in the Second Affiliated Hospital of Dalian Medical University from January 2015 to December 2018 were enrolled and randomly divided into observation group (n=50) and control group (n=50). In control group only conventional anesthesia was performed using 2 µg/kg fentanyl, 1.5 mg/kg propofol and 0.2 mg/kg atracurium, in addition to the proced...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Interferon-β sensitizes human glioblastoma cells to the cyclin-dependent kinase inhibitor, TG02. Oncol Lett. 2020 Apr;19(4):2649-2656 Authors: Lohmann B, Rhun EL, Silginer M, Epskamp M, Weller M Abstract Novel treatments for glioblastoma, the most common malignant primary brain tumor, are urgently required. Type I interferons (IFN) are natural cytokines primarily involved in the defense against viral infections, which may also serve a role in the control of cancer, notably in the suppression of the cancer stem cell phenotype. TG02 is a novel orally available cyclin-dependent kinase 9 inhibitor whi...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
PMID: 32213150 [PubMed - in process]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
Conclusions: The intraoperative use of antihypertensives such as hydralazine and sedatives such as propofol or dexmedetomidine leads to increased risk of HBEs during shoulder arthroscopic surgery under ISB in the sitting position. PMID: 32213804 [PubMed - as supplied by publisher]
Source: Korean Journal of Anesthesiology - Category: Anesthesiology Tags: Korean J Anesthesiol Source Type: research
Publication date: Available online 29 March 2020Source: Meat ScienceAuthor(s): Vladana Grabe┼ż, Bjørg Egelandsdal, Nils Petter Kjos, Ingrid Marie Håkenåsen, Liv Torunn Mydland, Jon Olav Vik, Elin Hallenstvedt, Hanne Devle, Margareth Øverland
Source: Meat Science - Category: Food Science Source Type: research
In this study, we determined the relationships between serum sclerostin and all-cause mortality, the prevalence of cardiovascular events (CVEs), and coronary artery calcifications (CACs) in dialysis patients.Methods: A total of 165 dialysis patients (84 hemodialysis [HD] and 81 peritoneal dialysis [PD]) were enrolled in this study. We performed multivariable linear regression analysis to test the relationships between serum sclerostin levels and demographics and clinical parameters. We also performed Cox proportional hazard regression analysis to determine independent predictors of overall survival and CVEs.Results: The me...
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
Authors: Kawada T PMID: 32216510 [PubMed - as supplied by publisher]
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
More News: Acetadote | Acetylcysteine | Anesthesia | Anesthesiology | Antidoxidants | Arrhythmia | Brain | Brain Cancers | Carbon Monoxide Poisoning | Cardiology | Cardiovascular | Cardiovascular & Thoracic Surgery | Chronic Kidney Disease | Clinical Trials | Congestive Heart Failure | Cozaar | Depression | Diets | Eating Disorders & Weight Management | Ganglions | Genetics | Guinea Health | Heart | Heart Disease | Heart Failure | High Fat | Hormones | Hyperactivity | Hypertension | Inderal | Ireland Health | Ischemic Stroke | Lidoderm | Losartan | Men | Neurology | Neurosurgery | Nutrition | Obesity | Obstructive Sleep Apnea | Perfusion | Physiology | Reflex Sympathetic Dystrophy | Renal Failure | Respiratory Medicine | Sleep Disorders | Sleep Medicine | Sodium | Spironolactone | Stroke | Study | Ureter and Renal Pelvis Cancer | Urology & Nephrology | Wheat