Dietary Vitamin D3 Deficiency Increases Resistance to Leishmania (Leishmania) amazonensis Infection in Mice

Conclusion Altogether, our results indicate that dietary VitD deficiency is able to decrease lesion growth and provide an increase in Th1 response in C57BL/6 and BALB/c mice upon L. (L.) amazonensis infection, although it does not decrease parasite burden in either of the murine models used. Thus, VitD may contribute to host susceptibility to murine tegumentary leishmaniasis. Further studies on the influence of immunonutrition in the leishmaniases are needed to better understand the immunobiology of these diseases. Author Contributions HdMG conceived and designed the experiments. GO-S, DB, MM, JEP, JCP, TR, AdF-M, and LF-C performed the experiments. GO-S, MM, LF-C, TR, and AdF-M analyzed data. IB, GO-S, DG, BR-B, and HdMG scientific discussion. HdMG, BR-B, and AV contributed reagents, materials and analysis tools. IB and HdMG wrote the paper. Funding We received financial support from Programa Jovem Cientista do Nosso Estado (Faperj – E-26/203.215/2015); Productivity Fellowships from Conselho Nacional de Desenvolvimento Científico e Tecnológico (304712/2016-7) and Agency for Support and Evaluation of Graduate Education (CAPES) Finance code 001. Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be found online at: https://w...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research