Should You Take Aspirin Every Day? Here ’s What the Science Says

Aspirin is best known as an over-the-counter painkiller. But acetylsalicylic acid, as it’s called chemically, has many other health benefits, as well as side effects, in the body that have only become clear in recent years. Here’s what the latest science says about the health benefits and side effects of aspirin, as well as which conditions it may treat and those it doesn’t appear to improve. (If you are taking aspirin for any reason other than for periodic pain relief, it’s best to consult with your doctor to confirm whether the benefits outweigh the risks in your particular case.) How aspirin affects heart health Aspirin’s second-best known effect is its ability to protect the heart. In people with heart disease who have already had a heart attack, it has been shown to lower the risk of having another. Studies consistently show that people who have had heart attacks or strokes and who take a low-dose aspirin (also known as baby aspirin, which at 81 mg is about a quarter of the dose of regular-strength aspirin) a day can significantly reduce their risk of having another event. Its protective benefits come from aspirin’s ability to lower inflammation, a condition that can attract clot-building factors within blood vessel walls. These can rupture, plugging up tiny vessels in the heart and blocking blood flow. Doctors now believe that taking a daily low-dose aspirin is also a cheap and easy way for people who do not yet have heart disease &m...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Drugs healthytime Source Type: news

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Authors: Perez BA, Slover J, Edusei E, Horan A, Anoushiravani A, Kamath AF, Nelson CL Abstract BACKGROUND: Total joint arthroplasty is one of the most common surgeries performed in the United States with total knee arthroplasty (TKA) being one of the most successful surgeries for restoring function and diminishing pain. Even with the demonstrated success of TKA and a higher prevalence of arthritis and arthritis related disability among minorities, racial and gender disparity remains a constant issue in providing care for the adult reconstruction patient. AIM: To assess the role of demographics and expectations ...
Source: World Journal of Orthopaedics - Category: Orthopaedics Tags: World J Orthop Source Type: research
Publication date: Available online 1 June 2020Source: MethodsAuthor(s): Reyhaneh Manafi-Farid, Najme Karamzade-Ziarati, Reza Vali, Felix M. Mottaghy, Mohsen Beheshti
Source: Methods - Category: Molecular Biology Source Type: research
Publication date: 15 August 2020Source: Journal of Molecular Liquids, Volume 312Author(s): Yanqing Wang, Qianqian Han, Hongmei Zhang, Yuanyuan Yan
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Publication date: Available online 2 June 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Dipanwita Das Mukherjee, N. Maruthi Kumar, Mukund P. Tantak, Satabdi Datta, Debabrata Ghosh Dastidar, Dalip Kumar, Gopal Chakrabarti
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
Authors: Huang JM, Pang ZY, Qi GB, Wang Z, Lv ZT Abstract OBJECTIVE: Currently published papers regarding the relationship between integrin alpha V (ITGAV) gene polymorphisms and rheumatoid arthritis (RA) are contradictory. The aim of this meta-analysis was to evaluate the associations between the ITGAV gene polymorphisms and RA risk. METHODS: Comprehensive literature search based on four electronic databases was applied to retrieve all related data. Two independent reviewers screened each article for eligibility according to the predetermined inclusion criteria. Pooled odds ratios (ORs) and 95% confidence inte...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
Publication date: Available online 1 June 2020Source: Saudi Journal of Biological SciencesAuthor(s): Zhenlong Qin, Lei Wang, Guoyan Li, Xuwen Qian, Jie Zhang, Ying Guo, Guokai Liu
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Publication date: 1 August 2020Source: Life Sciences, Volume 254Author(s): Manar Hamed Arafa, Nanies Sameeh Mohammad, Hebatallah Husseini Atteia
Source: Life Sciences - Category: Biology Source Type: research
Germinal center (GC) responses require B cells to respond to a dynamic set of intercellular and microenvironmental signals that instruct B cell positioning, differentiation, and metabolic reprogramming. RHO-associated coiled-coil–containing protein kinase 2 (ROCK2), a serine-threonine kinase that can be therapeutically targeted by ROCK inhibitors or statins, is a key downstream effector of RHOA GTPases. Although RHOA-mediated pathways are emerging as critical regulators of GC responses, the role of ROCK2 in B cells is unknown. Here, we found that ROCK2 was activated in response to key T cell signals like CD40 and IL-...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Th17 cells (producing IL-17) and Th9 cells (producing IL-9) exhibit functional plasticity, and their role in tumorigenicity is controversial. Th17/IL-17 and Th9/IL-9 exhibit critical, but often opposing, roles in tumor progression. In this issue of the JCI, Salazar et al. show that while IL-17 and IL-9 induced distinct but complementary molecular pathways, both cytokines also induced epithelial-mesenchymal transition (EMT) in lung cancer cells and promoted metastatic spreading. A key question before us now is whether IL-9 and IL-17 contribute to tumor progression in a sequential and stage-specific manner within the tumor microenvironment.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
The baroreceptor reflex is a powerful neural feedback that regulates arterial pressure (AP). Mechanosensitive channels transduce pulsatile AP to electrical signals in baroreceptors. Here we show that tentonin 3 (TTN3/TMEM150C), a cation channel activated by mechanical strokes, is essential for detecting AP changes in the aortic arch. TTN3 was expressed in nerve terminals in the aortic arch and nodose ganglion (NG) neurons. Genetic ablation of Ttn3 induced ambient hypertension, tachycardia, AP fluctuations, and impaired baroreflex sensitivity. Chemogenetic silencing or activation of Ttn3+ neurons in the NG resulted in an in...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
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