Exposure to Traffic-Related Air Pollution and Serum Inflammatory Cytokines in Children

Author Affiliations open 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden 2European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL, Université de Lyon, Lyon, France 3Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden 4Department of Paediatrics, Sachs’ Children’s Hospital, Stockholm, Sweden 5Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, Sweden PDF Version (136 KB) Abstract About This Article Supplemental Material Background: Long-term exposure to ambient air pollution can lead to adverse health effects in children; however, underlying biological mechanisms are not fully understood. Objectives: We evaluated the effect of air pollution exposure during different time periods on mRNA expression as well as circulating levels of inflammatory cytokines in children. Methods: We measured a panel of 10 inflammatory markers in peripheral blood samples from 670 8-y-old children in the Barn/Child, Allergy, Milieu, Stockholm, Epidemiology (BAMSE) birth cohort. Outdoor concentrations of nitrogen dioxide (NO2) and particulate matter (PM) with aerodynamic diameter 75th percentile of the exposure range in the cohort) and lower current exposure level at 8 y of age (PM10
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research

Related Links:

The American Congress of Rehabilitation Medicine (ACRM) offers an opportunity for members to be the guest editor of a Supplement to its journal, the Archives of Physical Medicine and Rehabilitation (Archives). The goal of the ACRM supplements is to publish high quality scientific manuscripts, which are thematically organized and of interest to ACRM members and to the general readership of the Archives. We are interested in proposals in all fields of rehabilitation, but especially those of interest to the ACRM membership as indicated by the existence of special interest and networking groups for brain injury, spinal cord in...
Source: Archives of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Organization news Source Type: research
Healthy women age 75 and older may not benefit from continued breast cancer...Read more on AuntMinnie.comRelated Reading: Is breast screening beneficial for sickly older women? ACP pushes breast cancer screening start from 40 to 50 DBT screening mammography benefits women over 65 Screening mammography still good for older women Age, not density, predicts interval breast cancer result
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
[Capital FM] Nairobi -The Kenya Film Classification Board has appealed to media and entertainment stakeholders to ensure that children are protected from inappropriate content in their programs.
Source: AllAfrica News: Pregnancy and Childbirth - Category: OBGYN Source Type: news
Basel, 25 February 2020 – Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the US Food and Drug Administration (FDA) has accepted the company’s Biologics License Application (BLA) for the fixed-dose combination (FDC) of Perjeta® (pertuzumab) and Herceptin® (trastuzumab) with hyaluronidase, administered by subc utaneous (SC) injection in combination with intravenous (IV) chemotherapy, for the treatment of eligible patients with HER2-positive breast cancer. The BLA for the FDC is based on results from the phase III FeDeriCa study, which demonstrated non-inferior levels of Perjeta in the blood (phar...
Source: Roche Investor Update - Category: Pharmaceuticals Source Type: news
Publication date: Available online 23 February 2020Source: Microbial PathogenesisAuthor(s): Ali Taghipour, Ali Rostami, Mahdi Sepidarkish, Fatemeh GhaffarifarAbstractThere are numerous epidemiological and experimental evidences to suggest that Ascaris lumbricoides infection is a neglected risk factor for development of asthma. For this purpose, we conducted a systematic review and meta-analysis for better understanding of this relationship. Systematic searching (PubMed, Scopus, Web of Science and Google Scholar) was done, up to September 30, 2019 to identify the relevant studies. We applied random-effects meta-analysis mod...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
ConclusionMetabolic biomarkers were affected by blood sample timing and underlying metabolic disease. The JECS will clarify the influences of metabolic status during pregnancy on the health and development of the offspring in future studies.
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionsThere is a rich traditional knowledge regarding the ethnomedicinal uses of Hypericum species in China. Through phytochemical and pharmacological studies, several medicinal Hypericum from China have yielded many bioactive phytochemicals, possessing antitumor, anti-inflammatory, antimicrobial, and neuroprotective properties. Hypericum species from China are potential sources of drugs to fight cancer and other chronic diseases. Remarkably, nearly half of Hypericum species in China have rarely been studied, and their ethnomedicinal potential have not been scientifically evaluated. Thus, in vitro mechanistic studies,...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsThe FAVOR III China study will be the first randomized trial to examine the effectiveness and cost-effectiveness of a QFR-guided versus an angiography-guided PCI strategy in CAD patients.
Source: American Heart Journal - Category: Cardiology Source Type: research
ConclusionsEV ‐miR‐21 in pleural lavage fluid is important as a diagnostic and prognostic factor. Moreover, EV‐miR‐21 induces the MMT, which can form premetastatic niches of dissemination in the pleural cavity.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
ConclusionsOral maintenance chemotherapy with S1 or capecitabine can improve OS in mNPC. Posttreatment EBV ‐DNA was not only an independent prognosis factor for mNPC but also can screen out beneficiaries of maintenance chemotherapy.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
More News: Allergy | Allergy & Immunology | Arthritis | Asthma | Biology | Borderline Tumor | Boys | Bronchial Tumour | Bulgaria Health | Cancer | Cancer & Oncology | Cancer in Adolescents | Cardiology | Cardiovascular | Cervical Cancer | Chemistry | Child Development | Childhood Cancer | Children | Chronic Obstructive Pulmonary | Databases & Libraries | Disability | Eczema | Education | Environmental Health | Epidemiology | Epithelial Cancer | Gastric (Stomach) Cancer | Gastroenterology | Genetics | Girls | Grants | Heart | Heart Attack | International Medicine & Public Health | Laboratory Medicine | Medical Ethics | Molecular Biology | Nutrition | Occupational Health | Pediatrics | Pregnancy | Residencies | Respiratory Medicine | Rheumatology | Smokers | Statistics | Study | Toxicology | Translocation | Universities & Medical Training | Women