Notes from the Rejuvenation Startup Summit, Held in Berlin in October 2022

We presented recent results showing reversal of liver inflammation and fibrosis in NASH model mice, and noted that we're raising funds to start our clinical development program leading to human trials. Therapies to reverse atherosclerosis progression will follow shortly on the heels of this work on NASH. Robin Mansukhani of Deciduous Therapeutics discussed their approach to immune system modulation via small molecules, training invariant natural killer cells to attack senescent cells. The point was made that engaging the immune system may be a way to work around many of the present unknowns regarding senescent cell status, biomarkers, and subtypes. Interestingly, a one-time treatment via their approach rouses immune cells for at least months thereafter, consistently clearing senescent cells over that time. Mike Kope of Cyclarity presented on their approach. Cyclarity is the renamed Underdog Pharmaceuticals, a spinout from the SENS Research Foundation that employs engineered cyclodextrins to bind 7-ketocholesterol. This is essentially a test of the degree to which 7-ketocholesterol is a meaningful cause of pathology in human atherosclerosis and other conditions. They have great cell data, showing that they can reverse the foam cell state that arises from 7-ketocholesterol exposure, and they also test in human plaques obtained from cadavers and surgical procedures. Despite a lack of animal models for 7-ketocholesterol presence in atherosclerotic disease, Clarity h...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs