miR-30a-5p mediates ferroptosis of hippocampal neurons in chronic cerebral hypoperfusion-induced cognitive dysfunction by modulating the SIRT1/NRF2 pathway
CONCLUSION: miR-30a-5p induces hippocampal neuronal ferroptosis and exacerbates post-CCH cognitive dysfunction by targeting SIRT1 and reducing NRF2 nuclear translocation.PMID:38636610 | DOI:10.1016/j.brainresbull.2024.110953 (Source: Cell Research)
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Lihua Wang Mingjie Li Bing Liu Ruihan Zheng Xinyi Zhang Shuoyi Yu Source Type: research
Ivermectin ameliorates acute myocarditis via the inhibition of importin-mediated nuclear translocation of NF- κB/p65
CONCLUSIONS: Ivermectin inhibits the nuclear translocation of NF-κB/p65 and the expression of major pro-inflammatory cytokines in myocarditis. The therapeutic effects of IVM on viral and non-viral myocarditis models suggest its potential application in the treatment of acute myocarditis.PMID:38636372 | DOI:10.1016/j.intimp.2024.112073 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 18, 2024 Category: Allergy & Immunology Authors: Xu Gao Yunling Xuan Zhou Zhou Chen Chen Dao Wen Wang Zheng Wen Source Type: research
miR-30a-5p mediates ferroptosis of hippocampal neurons in chronic cerebral hypoperfusion-induced cognitive dysfunction by modulating the SIRT1/NRF2 pathway
CONCLUSION: miR-30a-5p induces hippocampal neuronal ferroptosis and exacerbates post-CCH cognitive dysfunction by targeting SIRT1 and reducing NRF2 nuclear translocation.PMID:38636610 | DOI:10.1016/j.brainresbull.2024.110953 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - April 18, 2024 Category: Neurology Authors: Lihua Wang Mingjie Li Bing Liu Ruihan Zheng Xinyi Zhang Shuoyi Yu Source Type: research
miR-30a-5p mediates ferroptosis of hippocampal neurons in chronic cerebral hypoperfusion-induced cognitive dysfunction by modulating the SIRT1/NRF2 pathway
CONCLUSION: miR-30a-5p induces hippocampal neuronal ferroptosis and exacerbates post-CCH cognitive dysfunction by targeting SIRT1 and reducing NRF2 nuclear translocation.PMID:38636610 | DOI:10.1016/j.brainresbull.2024.110953 (Source: Brain Research)
Source: Brain Research - April 18, 2024 Category: Neurology Authors: Lihua Wang Mingjie Li Bing Liu Ruihan Zheng Xinyi Zhang Shuoyi Yu Source Type: research
Impact of MG132 induced-proteotoxic stress on αB-crystallin and desmin phosphorylation and O-GlcNAcylation and their partition towards cytoskeleton
Biochimie. 2024 Apr 16:S0300-9084(24)00079-8. doi: 10.1016/j.biochi.2024.04.004. Online ahead of print.ABSTRACTSmall Heat Shock Proteins are considered as the first line of defense when proteostasis fails. Among them, αB-crystallin is expressed in striated muscles in which it interacts with desmin intermediate filaments to stabilize them, maintaining cytoskeleton's integrity and muscular functionalities. Desmin is a key actor for muscle health; its targeting by αB-crystallin is thus crucial, especially in stress conditions. αB-crystallin is phosphorylated and O-GlcNAcylated. Its phosphorylation increases consecutively t...
Source: Biochimie - April 18, 2024 Category: Biochemistry Authors: Nathan Bulangalire Charlotte Claeyssen Onnik Agbulut Caroline Cieniewski-Bernard Source Type: research
Rare myxoid pleomorphic liposarcoma: a case report and literature review
We report a case of a middle-aged woman with a rapidly growing abdominal mass that was diagnosed as myxoid pleomorphic liposarcoma, a recently recognised, rare and aggressive subtype of liposarcoma. The tumour exhibits a combination of histological features from both myxoid liposarcoma and pleomorphic liposarcoma. Genetic analysis revealed mutations in TP53 and RB1, along with widespread loss of heterozygosity. However, no DDIT3 gene translocation or MDM2/CDK4 gene amplification was detected. These genetic characteristics can be used to distinguish this type of liposarcoma from others. Two unusual gene fusion/rearrangement...
Source: Journal of Clinical Pathology - April 18, 2024 Category: Pathology Authors: Shen, Y., Zhao, L., Li, A., Peng, Q., Liu, Q., Wang, L., Liu, Z. Tags: Short report Source Type: research
STMND1 is A Phylogenetically Ancient Stathmin which Localizes to Motile Cilia and Exhibits Nuclear Translocation that Is Inhibited When Soluble Tubulin Concentration Increases
Mol Biol Cell. 2024 Apr 17:mbcE23120514. doi: 10.1091/mbc.E23-12-0514. Online ahead of print.ABSTRACTStathmins are small, unstructured proteins that bind tubulin dimers and are implicated in several human diseases, but whose function remains unknown. We characterized a new stathmin, STMND1 (Stathmin Domain Containing 1) as the human representative of an ancient sub-family. STMND1 features a N-terminal myristoylated and palmitoylated motif which directs it to membranes and a tubulin-binding stathmin-like domain (SLD) that contains an internal nuclear localization signal. Biochemistry and proximity labeling showed that STMND...
Source: Mol Biol Cell - April 17, 2024 Category: Molecular Biology Authors: Xiang Deng Bryan O Seguinot Gary Bradshaw Jong Suk Lee Shannon Coy Marian Kalocsay Sandro Santagata Timothy Mitchison Source Type: research
TLR Engagement Induces an Alternate Pathway for BCR Signaling that Results in PKC δ Phosphorylation
J Immunol. 2024 Apr 17:ji2300784. doi: 10.4049/jimmunol.2300784. Online ahead of print.ABSTRACTRecently, we reported that preexposure of B cells to IL-4 induced an alternate, signalosome-independent BCR signaling pathway leading to protein kinase C (PKC)δ phosphorylation (pTyr311), which occurs in the membrane compartment. This is considered to represent a form of receptor crosstalk and signal integration. Unlike the classical BCR signaling pathway, Lyn kinase is indispensable for BCR-induced downstream events in the alternate pathway. Our previous report that alternate BCR signaling leading to ERK phosphorylation is trig...
Source: Journal of Immunology - April 17, 2024 Category: Allergy & Immunology Authors: Naeem Khan Yongmei Hu Clifford A Lowell Thomas L Rothstein Source Type: research
New insights into the structure and dynamics of the TOM complex in mitochondria
Biochem Soc Trans. 2024 Apr 17:BST20231236. doi: 10.1042/BST20231236. Online ahead of print.ABSTRACTTo date, there is no general physical model of the mechanism by which unfolded polypeptide chains with different properties are imported into the mitochondria. At the molecular level, it is still unclear how transit polypeptides approach, are captured by the protein translocation machinery in the outer mitochondrial membrane, and how they subsequently cross the entropic barrier of a protein translocation pore to enter the intermembrane space. This deficiency has been due to the lack of detailed structural and dynamic informa...
Source: Biochemical Society Transactions - April 17, 2024 Category: Biochemistry Authors: Stephan Nussberger Robin Ghosh Shuo Wang Source Type: research
High phosphate and calcium induce osteoblastic phenotype switching and calcification of corneal epithelial cells in a Runx2-dependent and synergistic manner; a possible mechanism of chronic kidney disease-associated corneal calcification
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15:167171. doi: 10.1016/j.bbadis.2024.167171. Online ahead of print.ABSTRACTPatients with advanced chronic kidney disease (CKD) have elevated circulating calcium × phosphate product levels and exhibit soft tissue calcification. Besides the cardiovascular system, calcification is commonly observed in the cornea in CKD patients on hemodialysis. Cardiovascular calcification is a cell-mediated, highly regulated process, and we hypothesized that a similar regulatory mechanism is implicated in corneal calcification with the involvement of corneal epithelial cells (CECs). We establish...
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Haneen Ababneh Andrea T óth Gr éta Lente Enik ő Balogh D ávid Máté Csiki B éla Nagy Árpád Szöőr Vikt ória Jeney Source Type: research
STMND1 is A Phylogenetically Ancient Stathmin which Localizes to Motile Cilia and Exhibits Nuclear Translocation that Is Inhibited When Soluble Tubulin Concentration Increases
Mol Biol Cell. 2024 Apr 17:mbcE23120514. doi: 10.1091/mbc.E23-12-0514. Online ahead of print.ABSTRACTStathmins are small, unstructured proteins that bind tubulin dimers and are implicated in several human diseases, but whose function remains unknown. We characterized a new stathmin, STMND1 (Stathmin Domain Containing 1) as the human representative of an ancient sub-family. STMND1 features a N-terminal myristoylated and palmitoylated motif which directs it to membranes and a tubulin-binding stathmin-like domain (SLD) that contains an internal nuclear localization signal. Biochemistry and proximity labeling showed that STMND...
Source: Mol Biol Cell - April 17, 2024 Category: Molecular Biology Authors: Xiang Deng Bryan O Seguinot Gary Bradshaw Jong Suk Lee Shannon Coy Marian Kalocsay Sandro Santagata Timothy Mitchison Source Type: research
High phosphate and calcium induce osteoblastic phenotype switching and calcification of corneal epithelial cells in a Runx2-dependent and synergistic manner; a possible mechanism of chronic kidney disease-associated corneal calcification
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15:167171. doi: 10.1016/j.bbadis.2024.167171. Online ahead of print.ABSTRACTPatients with advanced chronic kidney disease (CKD) have elevated circulating calcium × phosphate product levels and exhibit soft tissue calcification. Besides the cardiovascular system, calcification is commonly observed in the cornea in CKD patients on hemodialysis. Cardiovascular calcification is a cell-mediated, highly regulated process, and we hypothesized that a similar regulatory mechanism is implicated in corneal calcification with the involvement of corneal epithelial cells (CECs). We establish...
Source: Molecular Medicine - April 17, 2024 Category: Molecular Biology Authors: Haneen Ababneh Andrea T óth Gr éta Lente Enik ő Balogh D ávid Máté Csiki B éla Nagy Árpád Szöőr Vikt ória Jeney Source Type: research
TLR Engagement Induces an Alternate Pathway for BCR Signaling that Results in PKC δ Phosphorylation
J Immunol. 2024 Apr 17:ji2300784. doi: 10.4049/jimmunol.2300784. Online ahead of print.ABSTRACTRecently, we reported that preexposure of B cells to IL-4 induced an alternate, signalosome-independent BCR signaling pathway leading to protein kinase C (PKC)δ phosphorylation (pTyr311), which occurs in the membrane compartment. This is considered to represent a form of receptor crosstalk and signal integration. Unlike the classical BCR signaling pathway, Lyn kinase is indispensable for BCR-induced downstream events in the alternate pathway. Our previous report that alternate BCR signaling leading to ERK phosphorylation is trig...
Source: Journal of Immunology - April 17, 2024 Category: Allergy & Immunology Authors: Naeem Khan Yongmei Hu Clifford A Lowell Thomas L Rothstein Source Type: research
New insights into the structure and dynamics of the TOM complex in mitochondria
Biochem Soc Trans. 2024 Apr 17:BST20231236. doi: 10.1042/BST20231236. Online ahead of print.ABSTRACTTo date, there is no general physical model of the mechanism by which unfolded polypeptide chains with different properties are imported into the mitochondria. At the molecular level, it is still unclear how transit polypeptides approach, are captured by the protein translocation machinery in the outer mitochondrial membrane, and how they subsequently cross the entropic barrier of a protein translocation pore to enter the intermembrane space. This deficiency has been due to the lack of detailed structural and dynamic informa...
Source: Biochemical Society Transactions - April 17, 2024 Category: Biochemistry Authors: Stephan Nussberger Robin Ghosh Shuo Wang Source Type: research
High phosphate and calcium induce osteoblastic phenotype switching and calcification of corneal epithelial cells in a Runx2-dependent and synergistic manner; a possible mechanism of chronic kidney disease-associated corneal calcification
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 15:167171. doi: 10.1016/j.bbadis.2024.167171. Online ahead of print.ABSTRACTPatients with advanced chronic kidney disease (CKD) have elevated circulating calcium × phosphate product levels and exhibit soft tissue calcification. Besides the cardiovascular system, calcification is commonly observed in the cornea in CKD patients on hemodialysis. Cardiovascular calcification is a cell-mediated, highly regulated process, and we hypothesized that a similar regulatory mechanism is implicated in corneal calcification with the involvement of corneal epithelial cells (CECs). We establish...
Source: Biochimica et Biophysica Acta - April 17, 2024 Category: Biochemistry Authors: Haneen Ababneh Andrea T óth Gr éta Lente Enik ő Balogh D ávid Máté Csiki B éla Nagy Árpád Szöőr Vikt ória Jeney Source Type: research
