Pharmacological evaluation of new generation OXIZID synthetic cannabinoid receptor agonists
Eur J Pharmacol. 2024 Mar 30:176549. doi: 10.1016/j.ejphar.2024.176549. Online ahead of print.ABSTRACTSynthetic cannabinoid receptor agonists (SCRAs) remain one the largest classes of new psychoactive substances, and are increasingly associated with severe adverse effects and death compared to the phytocannabinoid Δ9-tetrahydrocannabinol (THC). In the attempt to circumvent the rapid emergence of novel SCRAs, several nations have implemented 'generic' legislations, or 'class-wide' bans based on common structural scaffolds. However, this has only encouraged the incorporation of new chemical entities, including distinct core...
Source: European Journal of Pharmacology - April 1, 2024 Category: Drugs & Pharmacology Authors: Monica Patel Xiaoxi Zheng Luli R Akinfiresoye Cassandra Prioleau Teneille D Walker Michelle Glass Julie A Marusich Source Type: research
A signaling cascade mediating fruit trait development via phosphorylation-modulated nuclear accumulation of JAZ repressor
J Integr Plant Biol. 2024 Apr 1. doi: 10.1111/jipb.13654. Online ahead of print.ABSTRACTIt is generally accepted that jasmonate-ZIM domain (JAZ) repressors act to mediate jasmonate (JA) signaling via CORONATINE-INSENSITIVE1 (COI1)-mediated degradation. Here, we report a cryptic signaling cascade where a JAZ repressor, FvJAZ12, mediates multiple signaling inputs via phosphorylation-modulated subcellular translocation rather than the COI1-mediated degradation mechanism in strawberry (Fragaria vesca). FvJAZ12 acts to regulate flavor metabolism and defense response, and was found to be the target of FvMPK6, a mitogen-activated...
Source: Journal of Integrative Plant Biology - April 1, 2024 Category: Biology Authors: Wei Wang Jinyao Ouyang Yating Li Changsheng Zhai Bing He Huahan Si Kunsong Chen Jocelyn K C Rose Wensuo Jia Source Type: research
CRISPR/Cas9n-mediated ELANE promoter editing for gene therapy of severe congenital neutropenia
Mol Ther. 2024 Mar 30:S1525-0016(24)00215-6. doi: 10.1016/j.ymthe.2024.03.037. Online ahead of print.ABSTRACTSevere congenital neutropenia (CN) is an inherited pre-leukemia bone marrow failure syndrome commonly caused by autosomal-dominant ELANE mutations (ELANE-CN). ELANE-CN patients are treated with daily injections of recombinant human granulocyte colony-stimulating factor (rhG-CSF). However, some patients do not respond to rhG-CSF, and approximately 15% of ELANE-CN patients develop myelodysplasia or acute myeloid leukemia. Here, we report the development of a curative therapy for ELANE-CN through inhibition of ELANE mR...
Source: Molecular Medicine - April 1, 2024 Category: Molecular Biology Authors: Masoud Nasri Malte Ritter Perihan Mir Benjamin Dannenmann Masako M Kaufmann Patricia Arreba-Tutusaus Yun Xu Natalia Borbaran-Bravo Maksim Klimiankou Claudia Lengerke Cornelia Zeidler Toni Cathomen Karl Welte Julia Skokowa Source Type: research
Pharmacological evaluation of new generation OXIZID synthetic cannabinoid receptor agonists
Eur J Pharmacol. 2024 Mar 30:176549. doi: 10.1016/j.ejphar.2024.176549. Online ahead of print.ABSTRACTSynthetic cannabinoid receptor agonists (SCRAs) remain one the largest classes of new psychoactive substances, and are increasingly associated with severe adverse effects and death compared to the phytocannabinoid Δ9-tetrahydrocannabinol (THC). In the attempt to circumvent the rapid emergence of novel SCRAs, several nations have implemented 'generic' legislations, or 'class-wide' bans based on common structural scaffolds. However, this has only encouraged the incorporation of new chemical entities, including distinct core...
Source: European Journal of Pharmacology - April 1, 2024 Category: Drugs & Pharmacology Authors: Monica Patel Xiaoxi Zheng Luli R Akinfiresoye Cassandra Prioleau Teneille D Walker Michelle Glass Julie A Marusich Source Type: research
A signaling cascade mediating fruit trait development via phosphorylation-modulated nuclear accumulation of JAZ repressor
J Integr Plant Biol. 2024 Apr 1. doi: 10.1111/jipb.13654. Online ahead of print.ABSTRACTIt is generally accepted that jasmonate-ZIM domain (JAZ) repressors act to mediate jasmonate (JA) signaling via CORONATINE-INSENSITIVE1 (COI1)-mediated degradation. Here, we report a cryptic signaling cascade where a JAZ repressor, FvJAZ12, mediates multiple signaling inputs via phosphorylation-modulated subcellular translocation rather than the COI1-mediated degradation mechanism in strawberry (Fragaria vesca). FvJAZ12 acts to regulate flavor metabolism and defense response, and was found to be the target of FvMPK6, a mitogen-activated...
Source: Journal of Integrative Plant Biology - April 1, 2024 Category: Biology Authors: Wei Wang Jinyao Ouyang Yating Li Changsheng Zhai Bing He Huahan Si Kunsong Chen Jocelyn K C Rose Wensuo Jia Source Type: research
A signaling cascade mediating fruit trait development via phosphorylation-modulated nuclear accumulation of JAZ repressor
J Integr Plant Biol. 2024 Apr 1. doi: 10.1111/jipb.13654. Online ahead of print.ABSTRACTIt is generally accepted that jasmonate-ZIM domain (JAZ) repressors act to mediate jasmonate (JA) signaling via CORONATINE-INSENSITIVE1 (COI1)-mediated degradation. Here, we report a cryptic signaling cascade where a JAZ repressor, FvJAZ12, mediates multiple signaling inputs via phosphorylation-modulated subcellular translocation rather than the COI1-mediated degradation mechanism in strawberry (Fragaria vesca). FvJAZ12 acts to regulate flavor metabolism and defense response, and was found to be the target of FvMPK6, a mitogen-activated...
Source: Journal of Integrative Plant Biology - April 1, 2024 Category: Biology Authors: Wei Wang Jinyao Ouyang Yating Li Changsheng Zhai Bing He Huahan Si Kunsong Chen Jocelyn K C Rose Wensuo Jia Source Type: research
MAPK15 controls cellular responses to oxidative stress by regulating NRF2 activity and expression of its downstream target genes
Redox Biol. 2024 Mar 28;72:103131. doi: 10.1016/j.redox.2024.103131. Online ahead of print.ABSTRACTOxidation processes in mitochondria and different environmental insults contribute to unwarranted accumulation of reactive oxygen species (ROS). These, in turn, rapidly damage intracellular lipids, proteins, and DNA, ultimately causing aging and several human diseases. Cells have developed different and very effective systems to control ROS levels. Among these, removal of excessive amounts is guaranteed by upregulated expression of various antioxidant enzymes, through activation of the NF-E2-Related Factor 2 (NRF2) protein. H...
Source: Cancer Control - March 31, 2024 Category: Cancer & Oncology Authors: Lorenzo Franci Giulia Vallini Franca Maria Bertolino Vittoria Cicaloni Giovanni Inzalaco Mattia Cicogni Laura Tinti Laura Calabrese Virginia Barone Laura Salvini Pietro Rubegni Federico Galvagni Mario Chiariello Source Type: research
Chrysin inhibits ferroptosis of cerebral ischemia/reperfusion injury via regulating HIF-1 α/CP loop
Biomed Pharmacother. 2024 Mar 30;174:116500. doi: 10.1016/j.biopha.2024.116500. Online ahead of print.ABSTRACTChrysin is a natural flavonoid with powerful neuroprotective capacity. Cerebral ischemia/reperfusion injury (CIRI) is associated with oxidative stress and ferroptosis. Hypoxia-inducible factor 1α (HIF-1α) and ceruloplasmin (CP) are the critical targets for oxidation reactions and iron transport. But the regulatory mechanism between them is still unclear. Transient middle cerebral artery occlusion (tMCAO) model in rats and oxygen and glucose deprivation/re-oxygenation (OGD/R) model in PC12 cells were applied. Path...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 31, 2024 Category: Drugs & Pharmacology Authors: Jinfeng Shang Jiakang Jiao Jingyi Wang Mingxue Yan Qiannan Li Lizha Shabuerjiang Guijinfeng Huang Qi Song Yinlian Wen Xiaolu Zhang Kai Wu Yiran Cui Xin Liu Source Type: research
Integrated In-Silico and In Vitro Analysis to Decipher the Contribution of Bisphenol-A in Cervical Cancer
Toxicology. 2024 Mar 29:153791. doi: 10.1016/j.tox.2024.153791. Online ahead of print.ABSTRACTBisphenol A (BPA) is a synthetic chemical widely used as a monomer for producing polycarbonate plastics. The present investigation employed an in-silico approach to identify BPA-responsive genes and comprehend the biological functions affected using in vitro studies. A Comparative Toxicogenomics Database search identified 29 BPA-responsive genes in cervical cancer (CC). Twenty-nine genes were screened using published datasets, and thirteen of those showed differential expression between normal and CC samples. Protein-Protein Inter...
Source: Toxicology - March 31, 2024 Category: Toxicology Authors: Nadeem Khan Ghani Divya Adiga Padmalatha Satwadi Rai Shama Prasada Kabekkodu Source Type: research
Knockdown of lncRNA NEAT1 suppresses streptococcus pneumoniae-induced ferroptosis in alveolar epithelial cells by regulating the Nrf2-GPX4 pathway
CONCLUSIONS: LncRNA NEAT1 knockdown suppressed SP-induced HPAEpiC ferroptosis by activating Nrf2-GPX4 pathway, thereby alleviating cell injury and inflammatory response.PMID:38556062 | DOI:10.1016/j.toxicon.2024.107705 (Source: Toxicon)
Source: Toxicon - March 31, 2024 Category: Toxicology Authors: Lin Xu Lu Zhang Yang Xiang Xiangyan Zhang Source Type: research
The decreased interface tension increased the transmembrane transport of soy hull polysaccharide-derived SCFAs in the Caco-2 cells
This study lays the theoretical foundation for understanding the structure-activity relationship of soy hull polysaccharides in the intestine.PMID:38556231 | DOI:10.1016/j.ijbiomac.2024.131261 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - March 31, 2024 Category: Biochemistry Authors: Li Li Mingjie Xia Lina Yang Yutang He He Liu Mengxi Xie Miao Yu Source Type: research
USP7 interacts with and destabilizes oncoprotein SET
Biochem Biophys Res Commun. 2024 Mar 27;709:149818. doi: 10.1016/j.bbrc.2024.149818. Online ahead of print.ABSTRACTOncoprotein SE translocation (SET) is frequently overexpressed in different types of tumors and correlated with poor prognosis of cancer patients. Targeting SET has been considered a promising strategy for cancer intervention. However, the mechanisms by which SET is regulated under cellular conditions are largely unknown. Here, by performing a tandem affinity purification-mass spectrometry (TAP-MS), we identify that the ubiquitin-specific protease 7 (USP7) forms a stable protein complex with SET in cancer cell...
Source: Biochemical and Biophysical Research communications - March 31, 2024 Category: Biochemistry Authors: Jianyuan Chen Zishan Jiao Yajing Liu Meng Zhang Donglai Wang Source Type: research
Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2
Exp Mol Med. 2024 Apr 1. doi: 10.1038/s12276-024-01203-4. Online ahead of print.ABSTRACTAcute liver injury is the basis of the pathogenesis of diverse liver diseases. However, the mechanism underlying liver injury is complex and not completely understood. In our study, we revealed that CERK, which phosphorylates ceramide to produce ceramide-1-phosphate (C1P), was the sphingolipid pathway-related protein that had the most significantly upregulated expression during acute liver injury. A functional study confirmed that CERK and C1P attenuate hepatic injury both in vitro and in vivo through antioxidant effects. Mechanistic st...
Source: Molecular Medicine - March 31, 2024 Category: Molecular Biology Authors: Wei Dong Qing Li Xing Lu Jianfeng Lan Zhidong Qiu Xuehong Wang Junnan Wang Xiaojiao Zheng Sifan Chen Chong Zhang Junfei Jin Source Type: research
Chrysin inhibits ferroptosis of cerebral ischemia/reperfusion injury via regulating HIF-1 α/CP loop
Biomed Pharmacother. 2024 Mar 30;174:116500. doi: 10.1016/j.biopha.2024.116500. Online ahead of print.ABSTRACTChrysin is a natural flavonoid with powerful neuroprotective capacity. Cerebral ischemia/reperfusion injury (CIRI) is associated with oxidative stress and ferroptosis. Hypoxia-inducible factor 1α (HIF-1α) and ceruloplasmin (CP) are the critical targets for oxidation reactions and iron transport. But the regulatory mechanism between them is still unclear. Transient middle cerebral artery occlusion (tMCAO) model in rats and oxygen and glucose deprivation/re-oxygenation (OGD/R) model in PC12 cells were applied. Path...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 31, 2024 Category: Drugs & Pharmacology Authors: Jinfeng Shang Jiakang Jiao Jingyi Wang Mingxue Yan Qiannan Li Lizha Shabuerjiang Guijinfeng Huang Qi Song Yinlian Wen Xiaolu Zhang Kai Wu Yiran Cui Xin Liu Source Type: research
Integrated In-Silico and In Vitro Analysis to Decipher the Contribution of Bisphenol-A in Cervical Cancer
Toxicology. 2024 Mar 29:153791. doi: 10.1016/j.tox.2024.153791. Online ahead of print.ABSTRACTBisphenol A (BPA) is a synthetic chemical widely used as a monomer for producing polycarbonate plastics. The present investigation employed an in-silico approach to identify BPA-responsive genes and comprehend the biological functions affected using in vitro studies. A Comparative Toxicogenomics Database search identified 29 BPA-responsive genes in cervical cancer (CC). Twenty-nine genes were screened using published datasets, and thirteen of those showed differential expression between normal and CC samples. Protein-Protein Inter...
Source: Toxicology - March 31, 2024 Category: Toxicology Authors: Nadeem Khan Ghani Divya Adiga Padmalatha Satwadi Rai Shama Prasada Kabekkodu Source Type: research
