Exploring new frontiers: cell surface vimentin as an emerging marker for circulating tumor cells and a promising therapeutic target in advanced gastric Cancer
CONCLUSION: In summary, leveraging CSV as a universal CTCs marker represents a significant breakthrough in advancing personalized medicine for patients with advanced GC. This research not only paves the way for tailored therapeutic strategies but also underscores the pivotal role of CSV in enhancing GC management, opening new frontiers for precision medicine.PMID:38685125 | DOI:10.1186/s13046-024-03043-6 (Source: Cell Research)
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Heming Li Yang-Zhuangzhuang Zhu Lu Xu Tao Han Jiasi Luan Xin Li Yuting Liu Zhi Wang Qiuge Liu Xiangyu Kong Chunpu Zou Lin Su Yifei Hou Xiao Chen Lujun Chen Ruoyu Wang Zihang Xu Mingfang Zhao Source Type: research
Exploring new frontiers: cell surface vimentin as an emerging marker for circulating tumor cells and a promising therapeutic target in advanced gastric Cancer
CONCLUSION: In summary, leveraging CSV as a universal CTCs marker represents a significant breakthrough in advancing personalized medicine for patients with advanced GC. This research not only paves the way for tailored therapeutic strategies but also underscores the pivotal role of CSV in enhancing GC management, opening new frontiers for precision medicine.PMID:38685125 | DOI:10.1186/s13046-024-03043-6 (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - April 29, 2024 Category: Cancer & Oncology Authors: Heming Li Yang-Zhuangzhuang Zhu Lu Xu Tao Han Jiasi Luan Xin Li Yuting Liu Zhi Wang Qiuge Liu Xiangyu Kong Chunpu Zou Lin Su Yifei Hou Xiao Chen Lujun Chen Ruoyu Wang Zihang Xu Mingfang Zhao Source Type: research
CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT
CONCLUSIONS: Our study identifies unbridled turnover of the potassium channel hERG as a mechanism supporting the interindividual susceptibility underlying diLQT development and demonstrates how this phenomenon is finely tuned by CAVIN1.PMID:38682330 | DOI:10.1161/CIRCULATIONAHA.123.063917 (Source: Circulation)
Source: Circulation - April 29, 2024 Category: Cardiology Authors: Zeina R Al Sayed C éline Pereira R émi Le Borgne Christine Viaris de Lesegno Charl ène Jouve Esthel P énard Adeline Mallet Nihar Masurkar Gildas Loussouarn Jean-Marc Verbavatz Christophe Lamaze David-Alexandre Tr égouët Jean-S ébastien Hulot Source Type: research
Asciminib for third-line treatment of chronic myeloid leukemia: Cost-effectiveness analysis based on treatment-free remission approach
CONCLUSION: Asciminib broadens therapeutic choices for patient's refractory or intolerant to 2 prior lines of treatment in a cost-effectiveness manner. The costs of drugs significantly impact the overall cost of the disease, emphasizing the importance of the selected discount rates for each drug. Given the relatively low incidence of CML, the introduction of asciminib has a limited budgetary impact, warranting individualized decisions based on patient`s clinical characteristics.PMID:38679535 | DOI:10.1016/j.farma.2024.03.008 (Source: Farmacia Hospitalaria)
Source: Farmacia Hospitalaria - April 28, 2024 Category: Drugs & Pharmacology Authors: Antonio Garcia Molina Source Type: research
Biochanin A: Disrupting the Inflammatory Vicious Cycle for Dry Eye Disease
This study investigated BCA's therapeutic potential for DED. Human corneal epithelial cells were cultured under hyperosmotic conditions to mimic DED. BCA treatment increased cell viability and decreased apoptosis and inflammatory cytokine expression. A DED mouse model was developed using female C57BL/6 mice in a controlled low-humidity environment combined with scopolamine injections. Mice received eye drops containing phosphate-buffered saline, low-dose BCA, or high-dose BCA. The effectiveness was evaluated by measuring tear volume, fluorescein staining, eye-closing ratio, corneal sensitivity and PAS staining. The levels ...
Source: European Journal of Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Taige Chen Nan Zhou Qi Liang Qi Li Boda Li Yiran Chu Di Zhang Zeying Chen Jia-Ruei Tsao Xuebing Feng Kai Hu Source Type: research
DNA methyltransferases-associated long non-coding RNA PRKCQ-AS1 regulate DNA methylation in myelodysplastic syndrome
CONCLUSION: DNMT-associated DE-lncRNA PRKCQ-AS1 may affects DNA methylation levels by regulating MTR and TET1.PMID:38679027 | DOI:10.1111/ijlh.14297 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - April 28, 2024 Category: Hematology Authors: Jian Wen Yongbin Wu Quanfang Luo Source Type: research
Asciminib for third-line treatment of chronic myeloid leukemia: Cost-effectiveness analysis based on treatment-free remission approach
CONCLUSION: Asciminib broadens therapeutic choices for patient's refractory or intolerant to 2 prior lines of treatment in a cost-effectiveness manner. The costs of drugs significantly impact the overall cost of the disease, emphasizing the importance of the selected discount rates for each drug. Given the relatively low incidence of CML, the introduction of asciminib has a limited budgetary impact, warranting individualized decisions based on patient`s clinical characteristics.PMID:38679535 | DOI:10.1016/j.farma.2024.03.008 (Source: Farmacia Hospitalaria)
Source: Farmacia Hospitalaria - April 28, 2024 Category: Drugs & Pharmacology Authors: Antonio Garcia Molina Source Type: research
Biochanin A: Disrupting the Inflammatory Vicious Cycle for Dry Eye Disease
This study investigated BCA's therapeutic potential for DED. Human corneal epithelial cells were cultured under hyperosmotic conditions to mimic DED. BCA treatment increased cell viability and decreased apoptosis and inflammatory cytokine expression. A DED mouse model was developed using female C57BL/6 mice in a controlled low-humidity environment combined with scopolamine injections. Mice received eye drops containing phosphate-buffered saline, low-dose BCA, or high-dose BCA. The effectiveness was evaluated by measuring tear volume, fluorescein staining, eye-closing ratio, corneal sensitivity and PAS staining. The levels ...
Source: European Journal of Pharmacology - April 28, 2024 Category: Drugs & Pharmacology Authors: Taige Chen Nan Zhou Qi Liang Qi Li Boda Li Yiran Chu Di Zhang Zeying Chen Jia-Ruei Tsao Xuebing Feng Kai Hu Source Type: research
FAM83B regulates mitochondrial metabolism and anti-apoptotic activity in pulmonary adenocarcinoma
This study aims to understand how increased FAM83B expression impacts mitochondrial activity, cell apoptosis, and chemotherapy effectiveness in LUAD. Multiple assays, such as CCK8, wound healing, EdU, and transwell assays, were employed to confirm the augmented chemotherapy resistance, heightened cell proliferation, migration, and invasion caused by FAM83B overexpression in LUAD cells. Furthermore, MIMP, MTG, and ATP assays were utilized to quantify changes in mitochondrial metabolism. In vitro functional assays were performed to evaluate the influence of FAM83B overexpression on the malignant progression and resistance me...
Source: Apoptosis - April 28, 2024 Category: Molecular Biology Source Type: research
Genes, Vol. 15, Pages 567: Distribution of BCR::ABL1 Transcripts in the Different Clinical Phases of Chronic Myeloid Leukemia: Effect on Hematological Parameters and Patient Survival
This study therefore aimed to determine the distribution of BCR::ABL1 mRNA variants in different clinical phases of CML and their effect on hematological parameters and patient survival. This study included 33 patients, whose demographic, clinical, and molecular data on BCR::ABL1 mRNA variants and hematological parameters were collected to identify potential associations. A total of 84.8% (n = 28) of patients had BCR::ABL1 translocation and increased platelet and basophil counts. The most frequent mRNA variant was b3a2 (64.3%), followed by b2a2 (28.6%) and e1a2 (3.6%). Concerning the clinical phases of CML, 75.8% (n = 25),...
Source: Genes - April 28, 2024 Category: Genetics & Stem Cells Authors: Pablo Romero-Morelos Ana Lilia Gonz ález-Yebra Anaid Herrer ías-García Francisco Arath Ru íz-Velázquez Luis Jonathan Bueno-Rosario Beatr íz González-Yebra Tags: Article Source Type: research
Acute Infectious Purpura Fulminans Complicated by Bacterial Translocation after Rectal Cancer Surgery: A Case Report
Medicina (Kaunas). 2024 Apr 17;60(4):644. doi: 10.3390/medicina60040644.ABSTRACTThe patient was a man in his 80s who had undergone laparoscopic anterior resection for rectal cancer. Bowel obstruction occurred on the third postoperative day but improved with a decompression tube by the fifth postoperative day. A high fever (in the 38 °C range) was also observed. Blood culture tests detected two sets of the gram-negative bacilli Klebsiella aerogenes within 24 h of collection. On the seventh postoperative day, the patient subsequently went into septic shock with disseminated intravascular coagulation (DIC). On the eighth pos...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Ryo Nakanishi Heita Ozawa Naoyuki Toyota Minori Mise Ritsuto Akutsu Shin Fujita Source Type: research
Acute Infectious Purpura Fulminans Complicated by Bacterial Translocation after Rectal Cancer Surgery: A Case Report
Medicina (Kaunas). 2024 Apr 17;60(4):644. doi: 10.3390/medicina60040644.ABSTRACTThe patient was a man in his 80s who had undergone laparoscopic anterior resection for rectal cancer. Bowel obstruction occurred on the third postoperative day but improved with a decompression tube by the fifth postoperative day. A high fever (in the 38 °C range) was also observed. Blood culture tests detected two sets of the gram-negative bacilli Klebsiella aerogenes within 24 h of collection. On the seventh postoperative day, the patient subsequently went into septic shock with disseminated intravascular coagulation (DIC). On the eighth pos...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Ryo Nakanishi Heita Ozawa Naoyuki Toyota Minori Mise Ritsuto Akutsu Shin Fujita Source Type: research
Noradrenaline enhances Na ‐K ATPase subunit expression by HuR‐induced mRNA stabilization and their transportation to the cell surface through PLC and PKC mediated pathway: Implications with REMS‐loss associated disorders
Rapid eye movement sleep deprivation associated elevated noradrenaline (NA) increases nucleus-to-cytoplasmic translocation of HuR. The latter then decreases degradation of the Na-K ATPase mRNA, resulting in stability of its mRNA, which in turn increased its translation without increasing the transcription. The increased Na-K ATPase subunit are then translocated to the neuronal membrane. Our findings not only explain a fundamental molecular mechanism of Na-K ATPase subunit expression, but it may also be exploited to ameliorate REMS-loss associated symptoms and disorders. AbstractRapid eye movement sleep (REMS) maintains bra...
Source: Journal of Neurochemistry - April 27, 2024 Category: Neuroscience Authors: Manjeet Kaur,
Rachna Mehta,
Rohini Muthuswami,
Birendra Nath Mallick Tags: ORIGINAL ARTICLE Source Type: research
Genes, Vol. 15, Pages 558: Genetic Mechanisms Driving Uterine Leiomyoma Pathobiology, Epidemiology, and Treatment
Borahay
Uterine leiomyomas (ULs) are the most common benign tumor of the uterus. They can be associated with symptoms including abnormal uterine bleeding, pelvic pain, urinary frequency, and pregnancy complications. Despite the high prevalence of UL, its underlying pathophysiology mechanisms have historically been poorly understood. Several mechanisms of pathogenesis have been suggested, implicating various genes, growth factors, cytokines, chemokines, and microRNA aberrations. The purpose of this study is to summarize the current research on the relationship of genetics with UL. Specifically, we performed a literature...
Source: Genes - April 27, 2024 Category: Genetics & Stem Cells Authors: Malini S. Ramaiyer Eslam Saad Irem Kurt Mostafa A. Borahay Tags: Review Source Type: research
Roles of AhR/CYP1s Signal Pathway Mediated ROS Production in Uremic Cardiomyopathy
CONCLUSION: This study provides evidence that the AhR/CYP1s pathway is activated in UCM rats, and this activation is correlated with the uremic toxin IS. In vitro studies indicate that IS can stimulate the AhR translocation in cardiomyocyte, triggering to the production of intracellular ROS via CYP1s. This process leads to prolonged oxidative stress stimulation and thus contributes to the progression of uremic toxin-mediated cardiomyopathy.PMID:38670245 | DOI:10.1016/j.toxlet.2024.04.005 (Source: Toxicology Letters)
Source: Toxicology Letters - April 26, 2024 Category: Toxicology Authors: Wei Lu Shi Cheng Jiarui Xu Zilong Xiao Yong Yu Qiwen Xie Yi Fang Ruizhen Chen Bo Shen Yeqing Xie Xiaoqiang Ding Source Type: research
