The complexity of extracellular vesicles: Bridging the gap between cellular communication and neuropathology
In this report, we review the roles that extracellular vesicles can play in biological processes and cellular dysfunction and pathobiology, particularly neurodegenerative diseases. We also examine the potential translational impacts of extracellular vesicles in diagnostics and therapeutic development. ER: endoplasmic reticulum; ROS: reactive oxygen species. AbstractBrain-derived extracellular vesicles (EVs) serve a prominent role in maintaining homeostasis and contributing to pathology in health and disease. This review establishes a crucial link between physiological processes leading to EV biogenesis and their impacts on...
Source: Journal of Neurochemistry - April 23, 2024 Category: Neuroscience Authors: Stephanie Tam,
Darcy Wear,
Christopher D. Morrone,
Wai Haung Yu Tags: SYSTEMATIC REVIEW Source Type: research
Variant ‐specific effects of GBA1 mutations on dopaminergic neuron proteostasis
Glucocerenrosidase1 (GBA1) mutations cause disruptions in endoplasmic reticulum (ER) and lysosome-related proteostasis pathways in induced pluripotent stem cell (iPSC)-derived dopaminergic neurons. SevereGBA1 mutations lead to increased ER stress (increased binding immunoglobulin protein (BiP) and protein disulfide isomerase (PDI) levels), total ubiquitination rates, and unfolded protein response (UPR). Defective chaperone-mediated autophagy (decreased heat-shock cognate protein 70 (HSC70) levels and decreased co-localization of lysosomal-associated membrane protein 2A (LAMP2A) and HSC70) is observed in iPSC-derived dopami...
Source: Journal of Neurochemistry - April 20, 2024 Category: Neuroscience Authors: G. Onal,
G. Yal çın‐Çakmaklı,
C. E. Özçelik,
I. Boussaad,
U. Ö. Ş. Şeker,
Hugo J. R. Fernandes,
H. Demir,
R. Krüger,
B. Elibol,
S. Dökmeci,
M. M. Salman Tags: ORIGINAL ARTICLE Source Type: research
Preface: Special issue: 14th International Conference on Brain Energy Metabolism: Energy substrates and microbiome govern brain bioenergetics and cognitive function with aging
This special issue, entitled “Energetics and cognition in aging brain: Impact of substrates and microbiome”, contains manuscripts from attendees at the 14th International Conference on Brain Energy Metabolism (ICBEM) held in Santa Fe, New Mexico, USA, October 24–27, 2022. Major topics include neuronal and mitochondrial en ergetics, higher brain functions involving astrocyte-neuron interactions, unique roles for glycogen, glycolytic upregulation during activation, determination of metabolite levels with genetically-encoded biosensors, dietary intervention in aging, gut-brain signaling, spreading depolarization and fun...
Source: Journal of Neurochemistry - April 13, 2024 Category: Neuroscience Authors: Mary C. McKenna,
In ‐Young Choi,
Arne Schousboe Tags: REVIEW Source Type: research
The following article for this Special Issue was previously published and can be found in its respective issue online: “How can I measure brain acetylcholine levels in vivo? Advantages and caveats of commonly used approaches”
Abstract:How can I measure brain acetylcholine levels in vivo? Advantages and caveats of commonly used approaches (Published in JNC 167.1 issue)https://onlinelibrary.wiley.com/doi/10.1111/jnc.15943 (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 12, 2024 Category: Neuroscience Tags: REVIEW Source Type: research
Issue Information
Front coverThis special issue related to the17th Symposium on Cholinergic Mechanisms (ISCM2022) highlights the progress in the molecular, neurochemical, pharmacological, toxicological, and clinical studies of the cholinergic system, underlining its complexity and impact on health and disease. The most recent ISCM2022 was organized in a hybrid format, allowing flexibility due to travel restrictions caused by the COVID pandemics.Image contentThe figure highlights the conference logo, with acetylcholine in Dubrovnik's common ornament carved in stone. Designed by Grafokor, Croatia.Read the full article‘Recent advances in cho...
Source: Journal of Neurochemistry - April 12, 2024 Category: Neuroscience Tags: ISSUE INFORMATION Source Type: research
The following article for this Special Issue was previously published and can be found in its respective issue online: “Whole‐brain neural connectivity to cholinergic neurons in the nucleus basalis of Meynert”
Abstract:Whole-brain neural connectivity to cholinergic neurons in the nucleus basalis of Meynert (Published
in JNC 166.2 issue)https://onlinelibrary.wiley.com/doi/10.1111/jnc.15873 (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 12, 2024 Category: Neuroscience Tags: ORIGINAL ARTICLE Source Type: research
The following article for this Special Issue was previously published and can be found in its respective issue online: “Acetylcholine release from striatal cholinergic interneurons is controlled differently depending on the firing pattern”
Abstract:Acetylcholine release from striatal cholinergic interneurons is controlled differently depending on the firing pattern (Published in JNC 167.1 issue)https://onlinelibrary.wiley.com/doi/10.1111/jnc.15950 (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 12, 2024 Category: Neuroscience Tags: ORIGINAL ARTICLE Source Type: research
The following article for this Special Issue was previously published and can be found in its respective issue online: “Long‐term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical neurons and BDNF levels without affecting the NGF synthesis”
Abstract:Long-term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical
neurons and BDNF levels without affecting the NGF synthesis (Published in JNC 163.2 issue)https://onlinelibrary.wiley.com/doi/10.1111/jnc.15683 (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 12, 2024 Category: Neuroscience Tags: ORIGINAL ARTICLE Source Type: research
The following article for this Special Issue was previously published and can be found in its respective issue online: “Detection of early Alzheimer’s disease‐like molecular alterations in a mouse model expressing human ApoE4”
Abstract:Detection of early Alzheimer ’s disease-like molecular alterations in a mouse model expressing human ApoE4 (Published in JNC 166.3 issue)https://onlinelibrary.wiley.com/doi/10.1111/jnc.15904 (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 12, 2024 Category: Neuroscience Tags: ORIGINAL ARTICLE Source Type: research
Correction to tumor necrosis factor receptor ‐associated factor 6 participates in early brain injury after subarachnoid hemorrhage in rats through inhibiting autophagy and promoting oxidative stress
(Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 10, 2024 Category: Neuroscience Tags: CORRECTION Source Type: research
Infiltration of immune cells to the brain and its relation to the pathogenesis of Alzheimer's and Parkinson's diseases
The disruption of the neurovascular unit and the infiltration of the peripheral immune cells into the central nervous system are hallmarks of neurodegenerative diseases. However, so far, the participation of infiltrating cells in the progression of these diseases has not been completely defined. In this work, we gather the evidence that exists until now which proposes the key events involved in the pathogenesis of the two main neurodegenerative diseases: Alzheimer's and Parkinson's diseases. We detail the alterations in the components that typically keep the neurovascular unit semi-permeable to the cellular interactions th...
Source: Journal of Neurochemistry - March 29, 2024 Category: Neuroscience Authors: Citlalli Netzahualcoyotzi,
Juan Jair Santill án‐Cigales,
Laura Virginia Adalid‐Peralta,
Iván Velasco Tags: REVIEW Source Type: research
Variant ‐specific in vitro neuronal network phenotypes and drug sensitivity in SCN2A developmental and epileptic encephalopathy
This study aims to assess the impact of GoF and LoFSCN2A variants on cultured neuronal network activity and explore their modulation by selected antiseizure medications (ASM). To this end, primary cortical cultures were generated from two knock-in mouse lines carrying variants corresponding to human GoFSCN2A p.R1882Q and LoF p.R853Q DEE variant. In vitro neuronal network activity and responses to ASM were analyzed using multielectrode array (MEA) between 2 and 4 weeks in culture. TheSCN2A p.R1882Q neuronal cultures showed significantly greater mean firing and burst firing. Their network synchronicity was also higher. I...
Source: Journal of Neurochemistry - March 28, 2024 Category: Neuroscience Authors: Linghan Jia,
Melody Li,
Svenja Pachernegg,
Alicia Sedo,
Nikola Jancovski,
Lisseth Estefania Burbano,
Kelley Dalby,
Alex Nemiroff,
Christopher Reid,
Snezana Maljevic,
Steven Petrou Tags: ORIGINAL ARTICLE Source Type: research
Amyloid pathology mediates the associations between plasma fibrinogen and cognition in non ‐demented adults
The current study aimed to comprehensively examine the interrelationships of fibrinogen, cognitive decline, and cerebrospinal fluid Alzheimer's disease biomarkers in non-demented individuals. Our findings were as follows: (1) Increased fibrinogen levels were associated with cognitive decline. (2) Increased fibrinogen levels were associated with A β pathology. (3) The impact of fibrinogen on cognition could be mediated by Aβ pathology. AbstractThough previous studies revealed the potential associations of elevated levels of plasma fibrinogen with dementia, there is still limited understanding regarding the influence of Al...
Source: Journal of Neurochemistry - March 27, 2024 Category: Neuroscience Authors: Li ‐Yun Ma,
Jing‐Hui Song,
Pei‐Yang Gao,
Ya‐Nan Ou,
Yan Fu,
Liang‐Yu Huang,
Zuo‐Teng Wang,
Dan‐Dan Zhang,
Rui‐Ping Cui,
Yin‐Chu Mi,
Lan Tan,
for the Alzheimer's Disease Neuroimaging Initiative Tags: ORIGINAL ARTICLE Source Type: research
Where alcohol use disorder meets interoception: A meta ‐analytic view on structural and functional neuroimaging data
We examined the results of two meta-analyses of gray matter reduction in alcohol use disorders (AUD) and functional representations of interoception (INT) for spatial convergence. No overlap was found (A). However, the AUD clusters are located in regions of the salience and sensorimotor networks that are strongly associated with the interoception clusters, as determined by coactivation (MACM; B, C) and resting-state analyses (D). Weak salience mapping may account for Interoceptive deficits in AUD that may be influenced by sensory stimulation. AbstractAlcohol use disorder (AUD) has been associated with changes in the proces...
Source: Journal of Neurochemistry - March 26, 2024 Category: Neuroscience Authors: Markus Muehlhan,
Carolin Spindler,
Sandra Nowaczynski,
Claudius Buchner,
Maximilian Fascher,
Sebastian Trautmann Tags: ORIGINAL ARTICLE Source Type: research
Dual effects of TGF ‐β inhibitor in ALS ‐ inhibit contracture and neurodegeneration
We found that halofuginone inhibits contracture and neurodegeneration by blocking the TGF- β/Smad signaling in amyotrophic lateral sclerosis (ALS). Halofuginone inhibits fibrosis in fibroblasts derived from SOD1 G93A mice. In SOD1 G93A mice, excessive TGF-β-induced fibrosis of the peripheral neuromuscular system causes joint contracture and muscle degeneration, resulting in motor dysfun ction, which is suppressed by halofuginone. Halofuginone also reduces glial cell-induced neuroinflammation and neuronal apoptosis. These dual therapeutic effects on both the neuromuscular and the central nervous systems with halofuginone ...
Source: Journal of Neurochemistry - March 22, 2024 Category: Neuroscience Authors: Do ‐Yeon Lee,
Young Nam Kwon,
Kwangkook Lee,
Sang Jeong Kim,
Jung‐Joon Sung Tags: ORIGINAL ARTICLE Source Type: research
