Differential serotonin transporter (5 ‐HTT) and 5‐HT2 receptor density in limbic and neocortical areas of adults and children with ASD: implications for SSRI efficacy
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 20, 2019 Category: Neuroscience Authors: Cheryl Brandenburg, Gene J. Blatt Tags: Original Article Source Type: research

The energetic brain ‐ A review from students to students
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 18, 2019 Category: Neuroscience Authors: M.P. Bordone, M.M. Salman, H.E. Titus, E. Amini, J. V. Andersen, B Chakraborti, A.V. Diuba, T. G. Dubouskaya, E. Ehrke, A.E. Freitas, G.B. Freitas, R.A. Gon çalves, D. Gupta, R. Gupta, S.R. Ha, I.A. Hemming, M. Jaggar, E. Jakobsen, P. K Tags: Review Source Type: research

A novel human Cdh1 mutation impairs anaphase promoting complex/cyclosome (APC/C) activity resulting in microcephaly, psychomotor retardation and epilepsy
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 18, 2019 Category: Neuroscience Authors: Cristina Rodr íguez, Irene Sánchez‐Morán, Sara Álvarez, Pilar Tirado, Daniel M Fernández‐Mayoralas, Beatriz Calleja‐Pérez, Ángeles Almeida, Alberto Fernández‐Jaén Tags: Original Article Source Type: research

Crosstalk between Cdk5/p35 and ERK1/2 signalling mediates spinal astrocyte activity via the PPAR γ pathway in a rat model of chronic constriction injury
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 17, 2019 Category: Neuroscience Authors: Yu Zhong, Jialin Chen, Jing Chen, Yanhua Chen, Li Li, Yubo Xie Tags: Original Article Source Type: research

Cordycepin improves behavioral ‐LTP and dendritic structure in hippocampal CA1 area of rats
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 17, 2019 Category: Neuroscience Authors: Yuan ‐Yuan Han, Zhao‐Hui Chen, Ying‐Jie Shang, Wen‐Wen Yan, Bao‐Yan Wu, Chu‐Hua Li Tags: Original Article Source Type: research

PPAR γ participates in the acquisition of brain ischemic tolerance induced by ischemic preconditioning via GLT‐1 in vivo and in vitro
In conclusion, PPARγ participates in regulating GLT‐1 during the acquisition of BIT induced by IPC.This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 17, 2019 Category: Neuroscience Authors: Cong ‐Cong Zhao, Meng‐Yang Jiang, Ling‐Yan Zhang, Yu‐Yan Hu, Zhen‐Jie Hu, Meng‐Yue Zhang, Jie Qi, A‐Chou Su, Nan Lou, Xiao‐Hui Xian, Jing‐Ge Zhang, Wen‐Bin Li, Min Zhang Tags: Original Article Source Type: research

Acid Sphingomyelinase – a Regulator of TRPC6 Channel Activity
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 16, 2019 Category: Neuroscience Authors: Stefanie Zeitler, Lian Ye, Aksana Andreyeva, Fabian Schumacher, Juliana Monti, Bernd N ürnberg, Gabriel Nowak, Burkhard Kleuser, Martin Reichel, Anna Fejtová, Johannes Kornhuber, Cosima Rhein, Kristina Friedland Tags: Original Article Source Type: research

Angiotensin II Mediates the Axonal Trafficking of Tyrosine Hydroxylase and Dopamine β‐Hydroxylase mRNAs and enhances Norepinephrine Synthesis in Primary Sympathetic Neurons
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 15, 2019 Category: Neuroscience Authors: Armaz Aschrafi, Adama Berndt, Jeffrey A Kowalak, Jenna R Gale, Anthony E Gioio, Barry B Kaplan Tags: Original Article Source Type: research

Leucine ‐rich repeat kinase 2 phosphorylation on synapsin I regulates glutamate release at pre‐synaptic sites
Leucine ‐rich repeat kinase 2 (LRRK2) is a multidomain protein extensively studied being mutated in familial Parkinson's disease. Because its kinase activity is a highly promising pharmacological target for the treatment of the disease, the identification of LRRK2 substrates is crucial to understand the c onsequence of LRRK2 kinase inhibition. Here we demonstrated that synapsin I is phosphorylated by LRRK2 at threonine 337 and 339. Functionally, we provided several evidences that LRRK2‐dependent phosphorylation of synapsin I impacts glutamate release and synaptic vesicles dynamics. Since LRRK2 muta tions display increa...
Source: Journal of Neurochemistry - July 10, 2019 Category: Neuroscience Authors: Antonella Marte, Isabella Russo, Claudia Rebosio, Pierluigi Valente, Elisa Belluzzi, Francesca Pischedda, Caterina Montani, Chiara Lavarello, Andrea Petretto, Ernesto Fedele, Pietro Baldelli, Fabio Benfenati, Giovanni Piccoli, Elisa Greggio, Tags: Original Article Source Type: research

Down ‐regulation of interleukin‐33 expression in oligodendrocyte precursor cells impairs oligodendrocyte lineage progression
This article has received a badge for *Open Materials* because it provided all relevant information to reproduce the study in the manuscript. The complete Open Science Disclosure form for this article can be found at the end of the article. More information about the Open Practices badges can be found athttps://cos.io/our-services/open-science-badges/.Open Science: This manuscript was awarded with the Open Materials BadgeFor more information see:https://cos.io/our-services/open-science-badges/ (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 10, 2019 Category: Neuroscience Authors: Hsin ‐Yu Sung, Wei‐Yu Chen, Hui‐Ting Huang, Chih‐Yen Wang, Song‐Bin Chang, Shun‐Fen Tzeng Tags: Original Article Source Type: research

Issue Information
Journal of Neurochemistry, Volume 150, Issue 2, Page 107-112, July 2019. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 10, 2019 Category: Neuroscience Tags: Issue Information Source Type: research

Issue Cover (July 2019)
Front cover:The effects of oligomeric species of α‐synuclein (αSO), neurotoxins of Parkinson's disease (PD), on astrocytes have not been directly addressed. Here, by using an early model of PD, we showed that αSO induced astrocyte reactivity and enhanced the synaptogenic capacity of human and murine astrocytes by increasing the levels of tran sforming growth factor beta 1 (TGF‐β1). Our study describes a new neuroprotective role of astrocytes against the neurotoxicity induced by αSO and sheds light on the cellular and molecular mechanisms of synaptic changes in the early stages of PD.Image c...
Source: Journal of Neurochemistry - July 10, 2019 Category: Neuroscience Tags: Issue Cover Source Type: research

Role of the Endolysosomal System in Parkinson's disease
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 9, 2019 Category: Neuroscience Authors: D.J. Vidyadhara, John E. Lee, Sreeganga S. Chandra Tags: Review Source Type: research

Effects of alpha ‐synuclein post‐translational modifications on metal binding
This article is part of thehttp://onlinelibrary.wiley.com/page/journal/14714159/homepage/virtual_issues.htmSpecial Issue Synuclein. AbstractParkinson ’s disease is the second most common neurodegenerative disorder worldwide. Neurodegeneration in this pathology is characterized by the loss of dopaminergic neurons in the substantia nigra, coupled with cytoplasmic inclusions known as Lewy bodies containing α‐synuclein. The brain is an organ tha t concentrates metal ions, and there is emerging evidence that a break‐down in metal homeostasis may be a critical factor in a variety of neurodegenerative diseases. &a...
Source: Journal of Neurochemistry - July 9, 2019 Category: Neuroscience Authors: Nazareno Gonz ález, Trinidad Arcos‐López, Annekatrin König, Liliana Quintanar, Mauricio Menacho Márquez, Tiago F. Outeiro, Claudio O. Fernández Tags: Review Source Type: research

Linoleic acid ‐derived metabolites constitute the majority of oxylipins in the rat pup brain and stimulate axonal growth in primary rat cortical neuron‐glia co‐cultures in a sex‐dependent manner
This study demonstrates that OXLAMs constitute the majority of oxylipins in the developing rat brain despite low relative abundanc e of their LA precursor, and highlights a novel role of LA and 13‐HODE in differentially influencing neuronal morphogenesis in the developing male and female brain.This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 8, 2019 Category: Neuroscience Authors: Marie Hennebelle, Rhianna K. Morgan, Sunjay Sethi, Zhichao Zhang, Hao Chen, Ana Cristina Grodzki, Pamela J. Lein, Ameer Y. Taha Tags: Original Article Source Type: research

Measurement of CSF α‐synuclein improves early differential diagnosis of mild cognitive impairment due to Alzheimer’s disease
This article has received a badge for *Open Materials* because it provided all relevant information to reproduce the study in the manuscript. The complete Open Science Disclosure form for this article can be found at the end of the article. More information about the Open Practices badges can be found athttps://cos.io/our-services/open-science-badges/. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 8, 2019 Category: Neuroscience Authors: Mar ía‐Salud García‐Ayllón, José‐Antonio Monge‐Argilés, Victoria Monge‐García, Francisco Navarrete, Maria‐Angeles Cortés‐Gómez, José Sánchez‐Payá, Jorge Manzanares, Ruth Gasparini‐Berenguer, Carlos Leiva‐Santana, Ja Tags: Original Article Source Type: research

Altered glucose catabolism in the presynaptic and perisynaptic compartments of SOD1G93A mouse spinal cord and motor cortex indicates that mitochondria are the site of bioenergetic imbalance in ALS
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 8, 2019 Category: Neuroscience Authors: Silvia Ravera, Carola Torazza, Tiziana Bonifacino, Francesca Provenzano, Claudia Rebosio, Marco Milanese, Cesare Usai, Isabella Panfoli, Giambattista Bonanno Tags: Original Article Source Type: research

Microglial ROCK is essential for chronic methylmercury ‐induced neurodegeneration
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 6, 2019 Category: Neuroscience Authors: Youichi Shinozaki, Yosuke Danjo, Schuichi Koizumi Tags: Original Article Source Type: research

Seasonal decrease in thermogenesis and increase in vasoconstriction explain seasonal response to 6N ‐cyclohexyladenosine‐induced hibernation in the Arctic Ground Squirrel (Urocitellus parryii)
This study aims to identify the neuronal mechanism underlying the seasonal difference in response to the adenosine A1 receptor agonist. Arctic ground squirrels were implanted with body temperature transmitters and housed at constant ambient temperature (2 °C) and light cycle (4L:20D). We administered CHA (6N ‐cyclohexyladenosine), an adenosine A1 receptor agonist in euthermic ‐summer phenotype and euthermic‐winter phenotype and used cFos and phenotypic immunoreactivity to identify cell groups affected by season and treatment. We observed lower core and subcutaneous temperature in winter animals and CHA produced a...
Source: Journal of Neurochemistry - July 5, 2019 Category: Neuroscience Authors: C Frare, M. E Jenkins, K. M McClure, K. L Drew Tags: Original Article Source Type: research

Aspirin upregulates Suppressor of Cytokine Signaling 3 in glial cells via PPAR α
This study underlines the importance of aspirin in upregulating SOCS3 in astrocytes and microglia. Aspirin increased the expression ofSocs3mRNA and protein in mouse astrocytes and BV ‐2 microglial cells in both a time‐ and dose‐dependent manner. While investigating mechanism, we found thatSocs3 gene promoter harbors PPRE and that aspirin upregulated SOCS3 in astrocytes isolated from PPAR β (‐/‐), but not PPARα (‐/‐), mice. Accordingly, aspirin increased SOCS3in vivo in the cortex of wild type and PPAR β (‐/‐), but not PPARα (‐/‐), mice. Similarly, aspirin treatment increased astr...
Source: Journal of Neurochemistry - July 5, 2019 Category: Neuroscience Authors: Sudipta Chakrabarti, Avik Roy, Tim Prorok, Dhruv Patel, Sridevi Dasarathi, Kalipada Pahan Tags: Original Article Source Type: research

Adenosine A1 and A2A receptors differently control synaptic plasticity in the mouse dorsal and ventral hippocampus
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 5, 2019 Category: Neuroscience Authors: Sara L. Reis, Henrique B. Silva, Margarida Almeida, Rodrigo A. Cunha, Ana P. Sim ões, Paula M. Canas Tags: Original Article Source Type: research

Drug Testing CMOS Chip Reveals Drug Modulation of Transmitter Release for Potential Therapeutic Applications
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 5, 2019 Category: Neuroscience Authors: Meng Huang, Shailendra S. Rathore, Manfred Lindau Tags: Original Article Source Type: research

Spinal high ‐mobility group box‐1 induces long‐lasting mechanical hypersensitivity through the toll‐like receptor 4 and upregulation of interleukin‐1β in activated astrocytes
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 4, 2019 Category: Neuroscience Authors: Norimitsu Morioka, Kazuki Miyauchi, Keita Miyashita, Takahiro Kochi, Fang Fang Zhang, Yoki Nakamura, Keyue Liu, Hidenori Wake, Kazue Hisaoka ‐Nakashima, Masahiro Nishibori, Yoshihiro Nakata Tags: Original Article Source Type: research

Nicotinamide phosphoribosyltransferase secreted from microglia via exosome during ischemic injury
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 3, 2019 Category: Neuroscience Authors: Yun ‐Bi Lu, Chen‐Xiang Chen, Jing Huang, Yu‐Xin Tian, Xian Xie, Ping Yang, Ming Wu, Chun Tang, Wei‐Ping Zhang Tags: Original Article Source Type: research

The Physiological Role of α‐Synuclein and Its Relationship to Parkinson's Disease
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 3, 2019 Category: Neuroscience Authors: David Sulzer, Robert H. Edwards Tags: Review Source Type: research

Cellular models of alpha ‐synuclein toxicity and aggregation
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 2, 2019 Category: Neuroscience Authors: Marion Delenclos, Jeremy D. Burgess, Agaristi Lamprokostopoulou, Tiago F. Outeiro, Kostas Vekrellis, Pamela J. McLean Tags: Review Source Type: research

Parkinson's Disease Biomarkers based on Alpha ‐synuclein
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 2, 2019 Category: Neuroscience Authors: Muneera Fayyad, Safa Salim, Nour Majbour, Daniel Erskine, Erik Stoops, Brit Mollenhauer, Omar M. A. El ‐Agnaf Tags: Review Source Type: research

Identification of compounds inhibiting prion replication and toxicity by removing PrPC from the cell surface
This study defines a new screening method and novel anti‐prion compounds supporting the notion that removing PrPC from the cell surface could represent a viable therapeutic strategy for prion diseases.This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - July 2, 2019 Category: Neuroscience Authors: Silvia Biggi, Michael Pancher, Claudia Stincardini, Silvia Luotti, Tania Massignan, Andrea Dalle Vedove, Andrea Astolfi, Pamela Gatto, Graziano Lolli, Maria Letizia Barreca, Valentina Bonetto, Valentina Adami, Emiliano Biasini Tags: Original Article Source Type: research

A role for Numb in Protein kinase M (PKM) ‐mediated increase in surface AMPA receptors during facilitation in Aplysia
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - June 29, 2019 Category: Neuroscience Authors: Carole A Farah, Tyler W Dunn, Margaret H Hastings, Larissa Ferguson, Cherry Gao, Katrina Gong, Wayne S Sossin Tags: Original Article Source Type: research

Alpha ‐synuclein oligomers and fibrils: a spectrum of species, a spectrum of toxicities
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - June 29, 2019 Category: Neuroscience Authors: Parvez Alam, Luc Bousset, Ronald Melki, Daniel E. Otzen Tags: Review Source Type: research

Contrasting patterns of ERK activation in the tail of the striatum in response to aversive and rewarding signals
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - June 27, 2019 Category: Neuroscience Authors: Giuseppe Gangarossa, Laia Castell, Liliana Castro, Pauline Tarot, Frederic Veyrunes, Pierre Vincent, Federica Bertaso, Emmanuel Valjent Tags: Original Article Source Type: research

Neuronal Ca2+ ‐dependent activator protein 1 (NCDAP1) induces neuronal cell death by activating p53 pathway following traumatic brain injury
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - June 25, 2019 Category: Neuroscience Authors: Masaaki Arai, Osamu Imamura, Nobuo Kondoh, Minori Dateki, Kunio Takishima Tags: Original Article Source Type: research

Issue Information
Journal of Neurochemistry, Volume 150, Issue 1, Page 1-5, July 2019. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - June 24, 2019 Category: Neuroscience Tags: Issue Information Source Type: research

Issue Cover (July 2019)
Front cover:The expression of human A β42 in the eyes of the animals is toxic and induces a rough eye phenotype. We have developed a small, peptidic inhibitor of Aβ42 (D‐AIP) and have shown that it is able to rescue Aβ42‐induced toxicity in the female animals as pictured. We believe that our D‐AIP peptide provides a novel mecha nism of action to reduce amyloid toxicity, thus providing a promising new prophylactic strategy to delay and/or prevent the onset of AD.Image Content: Representative live confocal images of the compound eye of female A β42 transgenic Drosophila melanogaster at day 5 post‐...
Source: Journal of Neurochemistry - June 24, 2019 Category: Neuroscience Tags: Issue Cover Source Type: research

Astrocyte ‐specific transcriptome analysis using the ALDH1L1 bacTRAP mouse reveals novel biomarkers of astrogliosis in response to neurotoxicity
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - June 21, 2019 Category: Neuroscience Authors: Lindsay T. Michalovicz, Kimberly A. Kelly, Saurabh Vashishtha, Rotem Ben ‐Hamo, Sol Efroni, Julie V. Miller, Alicia R. Locker, Kimberly Sullivan, Gordon Broderick, Diane B. Miller, James P. O'Callaghan Tags: Original Article Source Type: research

Probing activation ‐induced neurochemical changes using optogenetics combined with functional magnetic resonance spectroscopy (o‐fMRS): a feasibility study in the rat primary somatosensory cortex
AbstractKnowledge about biochemical processes is a prerequisite for a better understanding of mechanisms underlying brain activity.1H functional magnetic resonance spectroscopy (1H ‐fMRS) at high magnetic fields allows for the non‐invasive measurement of metabolic changes during brain activation. Optogenetics, on the other hand, has revolutionized the field of neuroscience. It was previously coupled with functional magnetic resonance imaging (fMRI) techniques in rodents en abling population‐specific targeting of cells, investigating brain networks with unprecedented in vivo precision.The coupling of optogenetics and1...
Source: Journal of Neurochemistry - June 21, 2019 Category: Neuroscience Authors: Nathalie Just, Cornelius Faber Tags: Original Article Source Type: research

Shank3 regulates striatal synaptic abundance of Cyld, a deubiquitinase specific for Lys63 ‐linked polyubiquitin chains
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - June 19, 2019 Category: Neuroscience Authors: Chunmei Jin, Shinhyun Kim, Hyojin Kang, Ki Na Yun, Yeunkum Lee, Yinhua Zhang, Yoonhee Kim, Jin Young Kim, Kihoon Han Tags: Original Article Source Type: research

Synaptophysin sustains presynaptic performance by preserving vesicular synaptobrevin ‐II levels
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - June 19, 2019 Category: Neuroscience Authors: Alexandros C. Kokotos, Callista B. Harper, Jamie R. K. Marland, Karen J. Smillie, Michael A. Cousin, Sarah L. Gordon Tags: Original Article Source Type: research

Activation of peroxisome proliferator ‐activated receptor delta suppresses BACE1 expression by up‐regulating SOCS1 in a JAK2/STAT1‐dependent manner
This article has received a badge for *Open Materials* because it provided all relevant information to reproduce the study in the manuscript. The complete Open Science Disclosure form for this article can be found at the end of the article. More information about the Open Practices badges can be found athttps://cos.io/our-services/open-science-badges/Open Science: This manuscript was awarded with the Open Materials BadgeFor more information see:https://cos.io/our-services/open-science-badges/ (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - June 18, 2019 Category: Neuroscience Authors: Won Jin Lee, Sun Ah Ham, Gyeong Hee Lee, Mi ‐Jung Choi, Hyunjin Yoo, Kyung Shin Paek, Dae‐Seog Lim, Kwonho Hong, Jung Seok Hwang, Han Geuk Seo Tags: Original Article Source Type: research

Autophagic degradation of stromal interaction molecule 2 mediates disruption of neuronal dendrites by endoplasmic reticulum stress
This article has received a badge for *Open Materials* because it provided all relevant information to reproduce the study in the manuscript. The complete Open Science Disclosure form for this article can be found at the end of the article. More information about the Open Practices badges can be found athttps://cos.io/our-services/open-science-badges/Open Science: This manuscript was awarded with the Open Materials BadgeFor more information see:https://cos.io/our-services/open-science-badges/ (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - June 18, 2019 Category: Neuroscience Authors: Jing Zhou, Juan Song, Shengzhou Wu Tags: Original Article Source Type: research

Plasma kallikrein ‐kinin system contributes to peripheral inflammation in temporal lobe epilepsy
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - June 17, 2019 Category: Neuroscience Authors: Priscila S. R. Sim ões, Alexia O. Zanelatto, Mirian C. Assis, Pedro Paulo V. Varella, Elza Marcia Yacubian, Henrique Carrete, Ricardo Centeno, Mariana S. Araujo, Esper A. Cavalheiro, Ivarne Luis S. Tersariol, Guacyara Motta, Maria da Graça Na Tags: Original Article Source Type: research

Sex differences in neonatal mouse brain injury after hypoxia ischemia and adaptaquin treatment
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - June 12, 2019 Category: Neuroscience Authors: Kenan Li, Tao Li, Yafeng Wang, Yiran Xu, Shan Zhang, Carsten Culmsee, Xiaoyang Wang, Changlian Zhu Tags: Original Article Source Type: research

Hyaluronan synthesis supports glutamate transporter activity
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - June 12, 2019 Category: Neuroscience Authors: Mariko Kato Hayashi, Tomoki Nishioka, Hideo Shimizu, Kanako Takahashi, Wataru Kakegawa, Tetsuri Mikami, Yuri Hirayama, Schuichi Koizumi, Sachiko Yoshida, Michisuke Yuzaki, Markku Tammi, Yuko Sekino, Kozo Kaibuchi, Yukari Shigemoto ‐Mogami, Tags: Original Article Source Type: research

Label ‐free distribution of anti‐amyloid D‐AIP in Drosophila melanogaster: prevention of Aβ42‐induced toxicity without side effects in transgenic flies
We report that our small synthetic D‐amino acid Aβ42‐oligomer interacting peptide (D‐AIP) was able to rescue the toxic ‘rough eye’ phenotype induced by human Aβ42 expression in a transgen icDrosophila model without obvious side effects (i.e. high dosage of D ‐AIP does not alter overall longevity, structure or function of wildtype flies). Overall, D‐AIP provides a novel mechanism of action to reduce amyloid toxicity, thus providing a promising new prophylactic strategy to delay and/or prevent the onset of AD. AbstractSoluble oligomers of the 42 ‐amino acid amyloid beta (Aβ42) pept...
Source: Journal of Neurochemistry - June 6, 2019 Category: Neuroscience Authors: Yifei Zhong, Adeola Shobo, Mark A. Hancock, Gerhard Multhaup Tags: Original Article Source Type: research

Post ‐ischemic salubrinal administration reduces necroptosis in a rat model of global cerebral ischemia
This study shows that necroptosis in cerebral cortex can be detected after 72 h of the insult and seems to be elicited before 48 h of reperfusion. The type of necroptosis here observed seems to be Tumor Necrosis Factor Receptor 1 (TNFR ‐1) independent. Necroptotic response is less evident in the CA1 hippocampal area than in cerebral cortex. The treatment with salubrinal administered 1 and 24 h after the ischemia, decreased the necroptotic marker levels and reduced the areas of selective neuronal loss, supporting the presence of ischemic‐dependent necroptosis, and the notion that ER stress is involved in the necroptotic...
Source: Journal of Neurochemistry - June 5, 2019 Category: Neuroscience Authors: Enrique Font ‐Belmonte, Irene F Ugidos, María Santos‐Galdiano, Paloma González‐Rodríguez, Berta Anuncibay‐Soto, Diego Pérez‐Rodríguez, Jose Manuel Gonzalo‐Orden, Arsenio Fernández‐López Tags: Original Article Source Type: research

Alpha ‐synuclein at the nexus of genes and environment: the impact of environmental enrichment and stress on brain health and disease
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - June 5, 2019 Category: Neuroscience Authors: Zinah Wassouf, Julia M. Schulze ‐Hentrich Tags: Review Source Type: research

Downregulation of interleukin ‐33 expression in oligodendrocyte precursor cells impairs oligodendrocyte lineage progression
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - June 5, 2019 Category: Neuroscience Authors: Hsin ‐Yu Sung, Wei‐Yu Chen, Hui‐Ting Huang, Chih‐Yen Wang, Song‐Bin Chang, Shun‐Fen Tzeng Tags: Original Article Source Type: research

Spreading of alpha ‐synuclein – relevant or epiphenomenon?
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - June 1, 2019 Category: Neuroscience Authors: Bryan Killinger, Jeffrey H. Kordower Tags: Review Source Type: research

LRRK2 phosphorylation on synapsin I regulates glutamate release at presynaptic sites
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - May 30, 2019 Category: Neuroscience Authors: Antonella Marte, Isabella Russo, Claudia Rebosio, Pierluigi Valente, Elisa Belluzzi, Francesca Pischedda, Caterina Montani, Chiara Lavarello, Andrea Petretto, Ernesto Fedele, Pietro Baldelli, Fabio Benfenati, Giovanni Piccoli, Elisa Greggio, Tags: Original Article Source Type: research

Corrigendum
Journal of Neurochemistry, Volume 149, Issue 5, Page 699-699, June 2019. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - May 29, 2019 Category: Neuroscience Tags: Corrigendum Source Type: research