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The many faces of vascular cognitive impairment
This article is part of the Special Issue “Vascular Dementia”. This Preface introduces the articles of the special issue on “Vascular Dementia” in which several recognized experts provide an overview of this research field. The brain is a highly vascularized organ and consequently, vascular dysfunction and related pathways affect cognitive performance and memory. Vascular dementia or vascular cognitive impairment is the second most common type of dementia after Alzheimer's disease, and both disorders often occur in parallel. With this special issue, we hope to provide insight and a stimulating dis...
Source: Journal of Neurochemistry - February 11, 2018 Category: Neurology Authors: H élène Girouard, Lisa M. Munter Tags: Preface Source Type: research

Early CALP2 expression and microglial activation are potential inducers of spinal IL ‐6 upregulation and bilateral pain following motor nerve injury
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - February 9, 2018 Category: Neuroscience Authors: Shao ‐Xia Chen, Shao‐Kun Wang, Pei‐Wen Yao, Guang‐Jie Liao, Xiao‐Dong Na, Yong‐Yong Li, Wei‐an Zeng, Xian‐Guo Liu, Ying Zang Tags: Original Article Source Type: research

Mitochondrial dysfunction in human skeletal muscle biopsies of lipid storage disorder
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - February 9, 2018 Category: Neuroscience Authors: B. Debashree, Manish Kumar, T.S. Keshava Prasad, Archana Natarajan, Rita Christopher, A. Nalini, P.S. Bindu, N. Gayathri, M.M. Srinivas Bharath Tags: Original Article Source Type: research

Stress ‐induced tRNA cleavage and tiRNA generation in rat neuronal PC12 cells
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - February 1, 2018 Category: Neurology Authors: Elkordy Alaa, Eikan Mishima, Kuniyasu Niizuma, Yasutoshi Akiyama, Miki Fujimura, Teiji Tominaga, Takaaki Abe Tags: Original Article Source Type: research

Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - February 1, 2018 Category: Neuroscience Authors: S E McKee, S Zhang, L Chen, J D Rabinowitz, T M Reyes Tags: Original Article Source Type: research

Elemental fingerprint as a cerebrospinal fluid biomarker for the diagnosis of Parkinson's disease
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - February 1, 2018 Category: Neurology Authors: Fabian Maass, Bernhard Michalke, Andreas Leha, Matthias Boerger, Inga Zerr, Jan ‐Christoph Koch, Lars Tönges, Mathias Bähr, Paul Lingor Tags: Original Article Source Type: research

Purinergic signaling in oligodendrocyte development and function
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 28, 2018 Category: Neuroscience Authors: Taylor G. Welsh, Sarah Kucenas Tags: Review Source Type: research

Reviewer selection biases editorial decisions on manuscripts
Abstract Many journals, including the Journal of Neurochemistry, enable authors to list peer reviewers as “preferred” or “opposed” suggestions to the editor. At the Journal of Neurochemistry, the handling editor (HE) may follow recommendations or select non‐author‐suggested reviewers (non‐ASRs). We investigated whether selection of author‐suggested reviewers (ASRs) influenced decisions on a paper, and whether differences might be related to a reviewers’, editor's or manuscript's geographical location. In this retrospective analysis, we compared original research articles submitted to t...
Source: Journal of Neurochemistry - January 27, 2018 Category: Neuroscience Authors: Laura Hausmann, Barbara Schweitzer, Frank A. Middleton, J örg B. Schulz Tags: Original Article Source Type: research

Sphingosine 1 ‐phosphate receptors regulate TLR4‐induced CXCL5 release from astrocytes and microglia
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 27, 2018 Category: Neuroscience Authors: Sinead A. O'Sullivan, Catherine O'Sullivan, Luke M. Healy, Kumlesh K. Dev, Graham K. Sheridan Tags: Original Article Source Type: research

Wnt is here! Could Wnt signalling be promoted to protect against Alzheimer disease?
Abstract This Editorial highlights an article in the current issue by Tapia‐Rojas and Inestrosa suggesting that attenuation of Wnt signalling may be a triggering factor for the pathogenesis of Alzheimer disease (AD) in the J20 mouse model of AD. Their study utilises Wnt signalling inhibitors that operate at different points in the signalling pathway. The molecular changes of several key Wnt signaling components are examined, along with a thorough analysis of both the amyloid and tau based pathologies in the mouse brain. Studies focusing on inhibition of Wnt signalling in AD mice have the potential to provide much needed ...
Source: Journal of Neurochemistry - January 26, 2018 Category: Neuroscience Authors: Brett Garner, Lezanne Ooi Tags: Editorial Highlight Source Type: research

Cerebrovascular and Alzheimer disease: fellow travelers or partners in crime?
This article is part of the Special Issue “Vascular Dementia”. Dementia in elderly individuals is often associated with multiple pathologies. In this review, we focus on findings from a meta‐analyses of longitudinal studies that suggest that a quarter of elderly have Alzheimer pathology without cognitive impairment, another quarter have asymptomatic cerebrovascular pathology without cognitive impairment, but that the combination doubles the chances that the individual will develop dementia. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 25, 2018 Category: Neurology Authors: Antonia Nucera, Vladimir Hachinski Tags: Review Source Type: research

Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 24, 2018 Category: Neuroscience Authors: R. Michelle Sar é, Tianjian Huang, Tom Burlin, Inna Loutaev, Carolyn Beebe Smith Tags: Original Article Source Type: research

Iron promotes α‐synuclein aggregation and transmission by inhibiting TFEB‐mediated autophagosome‐lysosome fusion
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 24, 2018 Category: Neuroscience Authors: Yousheng Xiao, Xiang Chen, Shuxuan Huang, Guihua Li, Mingshu Mo, Li Zhang, Chaojun Chen, Wenyuan Guo, Miaomiao Zhou, Zhuohua Wu, Luan Cen, Simei Long, Shaomin Li, Xinling Yang, Shaogang Qu, Zhong Pei, Pingyi Xu Tags: Original Article Source Type: research

Corticotropin ‐releasing hormone‐binding protein is upregulated by brain‐derived neurotrophic factor and is secreted in an activity‐dependent manner in rat cerebral cortical neurons
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 22, 2018 Category: Neuroscience Authors: Naoki Adachi, Shingo Suzuki, Hidetada Matsuoka, Satoko Fushimi, Junichiro Ono, Ken ‐ichi Ohta, Yohei Hirai, Takanori Miki, Hisatsugu Koshimizu Tags: Original Article Source Type: research

An emerging role of astrocytes in vascular contributions to cognitive impairment and dementia
This article is part of the Special Issue “Vascular Dementia”. We propose that hyperhomocysteinemia (HHcy) results in a pro‐inflammatory response at the vasculature, which activates the matrix metalloproteinase MMP9. MMP9 subsequently cleaves the a‐b dystroglycan complex, leading to disruption of the astrocytic connection with the vasculature. MMP9 also degrades the dystrophin Dp71 anchoring complex, resulting in the down‐regulation of astrocytic end‐foot channels. The end result of the end‐foot disruption is impaired potassium homeostasis in the brain and impaired neurovascular coupling. (Sour...
Source: Journal of Neurochemistry - January 22, 2018 Category: Neuroscience Authors: Brittani R. Price, Christopher M. Norris, Pradoldej Sompol, Donna M. Wilcock Tags: Review Source Type: research

Complex neuroprotective and neurotoxic effects of histone deacetylases
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 22, 2018 Category: Neuroscience Authors: Elizabeth A. Thomas, Santosh R. D'Mello Tags: Review Source Type: research

Issue Information
(Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 19, 2018 Category: Neuroscience Tags: Issue Information Source Type: research

Issue Cover (February 2018)
Front cover: The expression of p75 neurotrophin receptor is elevated in the brain of Alzheimer’s disease patients, suggesting its involvement in this disease. We propose a novel mechanism by which amyloid beta (Aβ) through p75 receptor contributes to a vicious cycle of amyloidogenesis. We found that Aβ can enhance amyloid precursor protein (APP) and beta‐site amyloid precursor protein cleaving enzyme‐1 (BACE1) phosphorylation, and their association and inclusion in endosomes through a p75‐dependent mechanism, leading to further Aβ generation. Cortical neurons were isolated from mouse expressing p...
Source: Journal of Neurochemistry - January 19, 2018 Category: Neuroscience Tags: Issue Cover Source Type: research

Alterations in mGlu5 receptor expression and function in the striatum in a rat depression model
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 16, 2018 Category: Neuroscience Authors: Li ‐Min Mao, John Q. Wang Tags: Original Article Source Type: research

Loss of STI1 ‐mediated neuronal survival and differentiation in disease‐associated mutations of prion protein
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 16, 2018 Category: Neuroscience Authors: M.C Landemberger, G.P Oliveira, C.F Machado, K.J Gollob, V.R Martins Tags: Original Article Source Type: research

Genetic Removal of eIF2 α Kinase PERK in Mice Enables Hippocampal L‐LTP Independent of mTORC1 Activity
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 16, 2018 Category: Neuroscience Authors: Helena R. Zimmermann, Wenzhong Yang, Brenna C. Beckelman, Nicole P. Kasica, Xueyan Zhou, Lucas Galli, Alexey G. Ryazanov, Tao Ma Tags: Original Article Source Type: research

Issue Information
(Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 9, 2018 Category: Neuroscience Tags: Issue Information Source Type: research

Issue Cover (January 2018)
Front cover: Sphingolipids, and particularly the versatile signalling molecule sphingosine‐1‐phosphate (S1P) are potent mediators regulating vascular functions such as endothelial barrier integrity. We analyzed changes of the sphingolipid metabolism after LPS injection as a model for septic encephalopathy and brain edema and found profound alterations both systemically with a drop in serum S1P as well as at the level of the blood‐brain barrier. Our findings point towards a therapeutic potential of drugs interfering with this pathway as novel approach for the detrimental overwhelming immune response in sepsis. Astrocy...
Source: Journal of Neurochemistry - January 9, 2018 Category: Neuroscience Tags: Issue Cover Source Type: research

Faim2 contributes to neuroprotection by erythropoietin in transient brain ischemia
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 8, 2018 Category: Neurology Authors: Daniel Komnig, Karen Gertz, Pardes Habib, Kay W. Nolte, Tareq Meyer, Marc A. Brockmann, Matthias Endres, Birgit Rathkolb, Martin Hrab ě de Angelis, Jörg B. Schulz, Björn H. Falkenburger, Arno Reich Tags: Original Article Source Type: research

Parkinson disease ‐related DJ‐1 modulates the expression of uncoupling protein 4 against oxidative stress
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 8, 2018 Category: Neurology Authors: Shaoqing Xu, Xiaodong Yang, Yiwei Qian, Qin Xiao Tags: Original Article Source Type: research

HFE Genotype Restricts the Response to Paraquat in a Mouse Model of Neurotoxicity
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 8, 2018 Category: Neurology Authors: Anne M. Nixon, Mark D. Meadowcroft, Elizabeth B. Neely, Amanda M. Snyder, Carson J. Purnell, Justin Wright, Regina Lamendella, Wint Nandar, Xuemei Huang, James R. Connor Tags: Original Article Source Type: research

The Role of Glutamate Signaling in Incentive Salience: Second ‐by‐second Glutamate Recordings in Awake Sprague Dawley Rats
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 8, 2018 Category: Neurology Authors: Seth R. Batten, Francois Pomerleau, Jorge Quintero, Greg A. Gerhardt, Joshua S. Beckmann Tags: Original Article Source Type: research

Bidirectional variation in glutamate efflux in the medial prefrontal cortex induced by selective positive and negative allosteric mGluR5 modulators
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 6, 2018 Category: Neuroscience Authors: Sarah N. Isherwood, Trevor W. Robbins, Jeffrey W. Dalley, Anton Pekcec Tags: Original Article Source Type: research

Kinetic modeling of [18F]VAT, a novel radioligand for PET imaging vesicular acetylcholine transporter (VAChT) in nonhuman primate brain
In this study, kinetics modeling methods were applied and compared for quantifying regional brain uptake of the VAChT‐specific PET radiotracer, ((‐)‐(1‐(‐8‐(2‐fluoroethoxy)‐3‐hydroxy‐1,2,3,4‐tetrahydronaphthalen‐2‐yl)piperidin‐4‐yl)(4‐fluorophenyl)‐methanone) ([18F]VAT) in macaques. Total volume distribution (VT) estimates were compared for one‐tissue compartment model (1TCM), two‐tissue compartment model (2TCM), Logan graphic analysis (LoganAIF) and multiple linear analysis (MA1) with arterial blood input function using data from three macaques. Using the cerebellum‐hemispheres as t...
Source: Journal of Neurochemistry - January 6, 2018 Category: Neuroscience Authors: Hongjun Jin, Xuyi Yue, Hui Liu, Junbin Han, Hubert Flores, Yi Su, Stanley M. Parsons, Joel S. Perlmutter, Zhude Tu Tags: Original Article Source Type: research

The APPswe/PS1A246E mutations in an astrocytic cell line leads to increased vulnerability to oxygen and glucose deprivation, Ca2+ dysregulation and mitochondrial abnormalities
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 6, 2018 Category: Neuroscience Authors: Mar ía Dolores Martin‐de‐Saavedra, Elisa Navarro, Ana J. Moreno‐Ortega, Mauricio P. Cunha, Izaskun Buendia, Pablo Hernansanz‐Agustín, Rafael León, María F. Cano‐Abad, Antonio Martínez‐Ruiz, Ricardo Martínez‐Murillo, Michael R. Duchen, Tags: Original Article Source Type: research

Palmitate induced C/EBP homologous protein activation leads to NF ‐κB ‐mediated increase in BACE1 activity and Amyloid beta genesis
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 6, 2018 Category: Neuroscience Authors: Gurdeep Marwarha, Jared Schommer, Jonah Lund, Trevor Schommer, Othman Ghribi Tags: Original Article Source Type: research

Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson's disease
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 1, 2018 Category: Neurology Authors: Jianhua Zhang, M Lillian Culp, Jason G Craver, Victor Darley ‐Usmar Tags: Review Source Type: research

Expression of the purine biosynthetic enzyme phosphoribosyl formylglycinamidine synthase (FGAMS) in neurons
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 1, 2018 Category: Neuroscience Authors: Colleen A. Mangold, Pamela J. Yao, Mei Du, Willard M. Freeman, Stephen J. Benkovic, Moriah L. Szpara Tags: Original Article Source Type: research

A dual role for Integrin α6β4 in modulating Hereditary Neuropathy with liability to Pressure Palsies
This study demonstrates that indirect interactions between an extracellular matrix receptor and a myelin protein influence the stability and function of myelinated fibers. This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 1, 2018 Category: Neurology Authors: Yannick Poitelon, Vittoria Matafora, Nicholas Silvestri, Desir ée Zambroni, Claire McGarry, Nora Serghany, Thomas Rush, Domenica Vizzuso, Felipe A. Court, Angela Bachi, Lawrence Wrabetz, Maria Laura Feltri Tags: Original Article Source Type: research

Ndrg2 deficiency ameliorates neurodegeneration in experimental autoimmune encephalomyelitis
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 1, 2018 Category: Neuroscience Authors: Thuong Manh Le, Mika Takarada ‐Iemata, Hieu Minh Ta, Jureepon Roboon, Hiroshi Ishii, Takashi Tamatani, Yasuko Kitao, Tsuyoshi Hattori, Osamu Hori Tags: Original Article Source Type: research

CART peptide in the nucleus accumbens shell inhibits cocaine ‐induced locomotor sensitization to transient overexpression of α‐Ca2+/Calmodulin‐dependent Protein Kinase II
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 1, 2018 Category: Neurology Authors: Lixia Xiong, Qing Meng, Xi Sun, Xiangtong Lu, Qiang Fu, Qinghua Peng, Jianhua Yang, Ki ‐Wan Oh, Zhen Zhen Hu Tags: Original Article Source Type: research

Validated multi ‐step approach for in vivo recording and analysis of optogenetically‐evoked glutamate in the mouse globus pallidus
This study advances the field of in vivo glutamate detection with combined optogenetics and amperometric recordings by providing a validated analysis framework for application in a wide variety of glutamate‐based approaches in neuroscience. This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - January 1, 2018 Category: Neuroscience Authors: Thomas Viereckel, Åsa Konradsson‐Geuken, Åsa Wallén‐Mackenzie Tags: Original Article Source Type: research

Repair gene O6 ‐methylguanine‐DNA methyltransferase is controlled by SP1 and up‐regulated by glucocorticoids, but not by temozolomide and radiation
Abstract Therapy of malignant glioma relies on treatment with the O6‐methylating agent temozolomide (TMZ) concomitant with ionizing radiation followed by adjuvant TMZ. For the treatment of recurrences, DNA chloroethylating drugs are also used. The main killing lesion induced by these drugs is O6‐alkylguanine. Since this damage is repaired by O6‐methylguanine‐DNA methyltransferase (MGMT), the repair enzyme represents a most important factor of drug resistance, limiting the therapy of malignant high‐grade gliomas. Although MGMT has been shown to be transcriptionally up‐regulated in rodents following genotoxic str...
Source: Journal of Neurochemistry - January 1, 2018 Category: Neurology Authors: Dorthe Aasland, Thomas R. Reich, Maja T. Tomicic, Olivier J. Switzeny, Bernd Kaina, Markus Christmann Tags: Original Article Source Type: research

Protein components of post ‐synaptic density lattice, a backbone structure for type I excitatory synapses
Abstract It is essential to study the molecular architecture of post‐synaptic density (PSD) to understand the molecular mechanism underlying the dynamic nature of PSD, one of the bases of synaptic plasticity. A well‐known model for the architecture of PSD of type I excitatory synapses basically comprises of several scaffolding proteins (scaffold protein model). On the contrary, ‘PSD lattice’ observed through electron microscopy has been considered a basic backbone of type I PSDs. However, major constituents of the PSD lattice and the relationship between the PSD lattice and the scaffold protein model, remai...
Source: Journal of Neurochemistry - December 29, 2017 Category: Neurology Authors: Tatsuo Suzuki, Kiyokazu Kametani, Weiheng Guo, Weidong Li Tags: Original Article Source Type: research

Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1 ‐linked amyotrophic lateral sclerosis mice
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - December 28, 2017 Category: Neuroscience Authors: Seiji Watanabe, Okiru Komine, Fumito Endo, Keisuke Wakasugi, Koji Yamanaka Tags: Original Article Source Type: research

Endotoxemia rocks sphingolipid metabolism at the blood –brain barrier
In this issue of the Journal of Neurochemistry, Vutukuri et al. evaluate the impact of endotoxemia‐induced encephalopathy on the sphingosine‐1‐phosphate (S1P) signaling pathway at the blood–brain barrier (BBB). Four hours after intraperitoneal administration of lipopolysaccharides (LPS, 4 mg/kg) to mice, they first demonstrate BBB dysfunction and then evaluate changes in sphingolipid metabolites in serum, isolated brain microvessels (MBMV), and whole brain. In parallel, they investigate the fate of indicated S1P generating and metabolizing enzymes and S1P receptors in brain and MBMV. S1P levels decrea...
Source: Journal of Neurochemistry - December 28, 2017 Category: Neurology Authors: Eric Camerer Tags: Editorial Highlight Source Type: research

G5G2.5 core ‐shell tecto‐dendrimer specifically targets reactive glia in brain ischemia
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - December 27, 2017 Category: Neuroscience Authors: Veronica Murta, Priscila Schilrreff, Gerardo Rosciszewski, Maria Jose Morrilla, Alberto Javier Ramos Tags: Original Article Source Type: research

Fibroblast growth factor 2 regulates activity and gene expression of human post ‐mitotic excitatory neurons
Abstract Many neuropsychiatric disorders are thought to result from subtle changes in neural circuit formation. We used human embryonic stem cells and induced pluripotent stem cells (hiPSCs) to model mature, post‐mitotic excitatory neurons and examine effects of fibroblast growth factor 2 (FGF2). FGF2 gene expression is known to be altered in brain regions of major depressive disorder (MDD) patients and FGF2 has anti‐depressive effects in animal models of depression. We generated stable inducible neurons (siNeurons) conditionally expressing human neurogenin‐2 (NEUROG2) to generate a homogenous population of post‐mi...
Source: Journal of Neurochemistry - December 27, 2017 Category: Neuroscience Authors: Shweta Gupta, Tanya M ‐Redmond, Fan Meng, Andrew Tidball, Huda Akil, Stanley Watson, Jack M. Parent, Michael Uhler Tags: Original Article Source Type: research

Microglia modulation through external vagus nerve stimulation in a murine model of Alzheimer's disease
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - December 21, 2017 Category: Neuroscience Authors: Robert Kaczmarczyk, Dario Tejera, Bruce J. Simon, Michael T. Heneka Tags: Original Article Source Type: research

Cerebrovascular and alzheimer disease: fellow travellers or partners in crime?
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - December 21, 2017 Category: Neuroscience Authors: Antonia Nucera, Vladimir Hachinski Tags: Review Source Type: research

Defective trafficking of Kv2.1 channels in MPTP ‐induced nigrostriatal degeneration
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - December 19, 2017 Category: Neuroscience Authors: Ru ‐Yi Chao, Chia‐Hui Cheng, Sheng‐Nan Wu, Pei‐Chun Chen Tags: Original Article Source Type: research

The non ‐peptidic δ‐opioid receptor agonist Tan‐67 mediates neuroprotection post‐ischemically and is associated with altered amyloid precursor protein expression, maturation and processing in mice
In this study, we examined whether post‐ischemic administration of Tan‐67 in stroke mice is also neuroprotective and whether the treatment affects expression, maturation and processing of the amyloid precursor protein (APP). A focal cerebral I/R model in mice was induced by middle cerebral artery occlusion for 1 h and Tan‐67 (1.5, 3 or 4.5 mg/kg) was administered via the tail vein at 1 h after reperfusion. Alternatively, naltrindole, a selective DOR antagonist (5 mg/kg), was administered 1 h before Tan‐67 treatment. Our results showed that post‐ischemic administration of Tan‐67 (3&...
Source: Journal of Neurochemistry - December 19, 2017 Category: Neurology Authors: Jia ‐Wei Min, Yanying Liu, David Wang, Fangfang Qiao, Hongmin Wang Tags: Original Article Source Type: research

Mechanisms of neuroprotection against ischemic insult by stress ‐inducible phosphoprotein‐1/prion protein complex
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - December 18, 2017 Category: Neurology Authors: Flavio H. Beraldo, Valeriy G. Ostapchenko, Jason Z. Xu, Gianni M. Di Guglielmo, Jue Fan, Peter J. Nicholls, Marc G. Caron, Vania F. Prado, Marco A. M. Prado Tags: Original Article Source Type: research

Reduced blood ‐brain barrier expression of fatty acid‐binding protein 5 is associated with increased vulnerability of APP/PS1 mice to cognitive deficits from low omega‐3 fatty acid diets
This study reports a 42.1 ± 12.6% decrease in the BBB transport of 14C‐DHA in 8‐month‐old AD transgenic mice (APPswe,PSEN1∆E9) relative to wild‐type mice, associated with a 34.5 ± 6.7% reduction in FABP5 expression in isolated brain capillaries of AD mice. Furthermore, short‐term spatial and recognition memory deficits were observed in AD mice on a 6‐month n‐3 fatty acid‐depleted diet, but not in AD mice on control diet. This intervention led to a dramatic reduction (41.5 ± 11.9%) of brain DHA levels in AD mice. This study demonstrates FABP5 deficiency an...
Source: Journal of Neurochemistry - December 18, 2017 Category: Neurology Authors: Yijun Pan, Kwok H. C. Choy, Philip J. Marriott, Siew Y. Chai, Martin J. Scanlon, Christopher J. H. Porter, Jennifer L. Short, Joseph A. Nicolazzo Tags: Original Article Source Type: research

Issue Information
(Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - December 18, 2017 Category: Neurology Tags: Issue Information Source Type: research