The role of pericytes in brain disorders: from the periphery to the brain
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - May 20, 2019 Category: Neuroscience Authors: Chanawee Hirunpattarasilp, David Attwell, Felipe Freitas Tags: Review Source Type: research

Alterations in Synaptic Function and Plasticity in Huntington Disease
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - May 16, 2019 Category: Neuroscience Authors: Amy I. Smith ‐Dijak, Marja D. Sepers, Lynn A. Raymond Tags: Review Source Type: research

Current status and potential role of circular RNAs in neurological disorders
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - May 16, 2019 Category: Neuroscience Authors: Shanshan Lu, Xue Yang, Chudong Wang, Siqi Chen, Shuang Lu, Weitao Yan, Kun Xiong, Fengxia Liu, Jie Yan Tags: Review Source Type: research

Effects of alpha ‐synuclein posttranslational modifications on metal binding
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - May 16, 2019 Category: Neuroscience Authors: Nazareno Gonz ález, Trinidad Arcos‐López, Annekatrin König, Liliana Quintanar, Mauricio Menacho Márquez, Tiago F. Outeiro, Claudio O. Fernández Tags: Review Source Type: research

Amyloid beta25 ‐35 impairs docosahexaenoic acid efflux by down‐regulating fatty acid transport protein 1 (FATP1/SLC27A1) protein expression in human brain capillary endothelial cells
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - May 15, 2019 Category: Neuroscience Authors: Yusuke Ochiai, Yasuo Uchida, Masanori Tachikawa, Pierre ‐Olivier Couraud, Tetsuya Terasaki Tags: Original Article Source Type: research

Screening the expression of several miRNAs from TaqMan Low Density Array in traumatic brain injury: miR ‐219a‐5p regulates neuronal apoptosis by modulating CCNA2 and CACUL1
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - May 11, 2019 Category: Neuroscience Authors: Jing Yan, Xiaomin Bu, Zhuoling Li, Jia Wu, Cheng Wang, Dandan Li, Jiaxi Song, Junjun Wang Tags: Original Article Source Type: research

Label ‐free distribution of anti‐amyloid D‐AIP in Drosophila melanogaster: prevention of Ab42‐induced toxicity without side effects in transgenic flies
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - May 11, 2019 Category: Neuroscience Authors: Yifei Zhong, Adeola Shobo, Mark A. Hancock, Gerhard Multhaup Tags: Original Article Source Type: research

Measurement of CSF ∝‐synuclein improves early differential diagnosis of mild cognitive impairment due to Alzheimer's disease
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - May 11, 2019 Category: Neuroscience Authors: M.S. Garc ía‐Ayllón, J.A. Monge‐Argilés, V. Monge‐García, F. Navarrete, M.A. Cortés‐Gómez, J. Sánchez‐Payá, J. Manzanares, R. Gasparini‐Berenguer, C. Leiva‐Santana, J. Sáez‐Valero Tags: Original Article Source Type: research

News & ISN April 2019
ObituaryWe are very sad that the ISN lost its President Kazuhiro Ikenaka, Professor and Chairman at National Institute for Physiological Sciences (NIPS), Director of Okazaki Institute of Integrative Biology. JNeurochem published an Obituary to value his outstanding achievements: Akio Wanaka et  al. (2019) OBITUARY Kazuhiro Ikenaka (1952‐2018).https://doi.org/10.1111/jnc.14679 (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - May 9, 2019 Category: Neuroscience Tags: News & ISN April 2019 Source Type: research

Synthetic testosterone derivatives modulate rat P2X2 and P2X4 receptor channel gating
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - May 9, 2019 Category: Neuroscience Authors: Sonja Sivcev, Barbora Slavikova, Marian Rupert, Milorad Ivetic, Michaela Nekardova, Eva Kudova, Hana Zemkova Tags: Original Article Source Type: research

Release parameters during progressive degeneration of dopamine neurons in a mouse model reveal earlier impairment of spontaneous than forced behaviors
We asked how the ability to release dopamine (DA) relates to the ability to carry out spontaneous, versus forced motor activities, taking advantage of a neurotoxin ‐free transgenic mouse model with degeneration specifically of the DA system. Usingex  vivo fast ‐scan cyclic voltammetry of brain slices, we find that impairment of open field locomotion and rearing began already at 10 weeks, in parallel with a modest decline of evoked DA release while rotarod performance was not impaired until mice were 16 weeks old, when evoked DA release in striatum had decreased to 40% of wild‐type levels. We conclude t...
Source: Journal of Neurochemistry - May 9, 2019 Category: Neuroscience Authors: Yuan ‐Hao Chen, Tsung‐Hsun Hsieh, Tung‐Tai Kuo, Jen‐Hsin Kao, Kuo‐Hsing Ma, Eagle Yi‐Kung Huang, Yu‐Ching Chou, Lars Olson, Barry J. Hoffer Tags: Original Article Source Type: research

How is alpha ‐synuclein cleared from the cell?
This article is part of the Special Issue “Synuclein”. AbstractThe levels and conformers of alpha ‐synuclein are critical in the pathogenesis of Parkinson's Disease and related synucleinopathies. Homeostatic mechanisms in protein degradation and secretion have been identified as regulators of alpha‐synuclein at different stages of its intracellular trafficking and transcellular propagation. Here we review pathways involved in the removal of various forms of alpha‐synuclein from both the intracellular and extracellular environment. Proteasomes and lysosomes are likely to play complementary roles in the rem...
Source: Journal of Neurochemistry - May 8, 2019 Category: Neuroscience Authors: Leonidas Stefanis, Evangelia Emmanouilidou, Marina Pantazopoulou, Deniz Kirik, Kostas Vekrellis, George K. Tofaris Tags: Review Source Type: research

Activation of PPAR δ suppresses BACE1 expression by upregulating SOCS1 in a JAK2/STAT1‐dependent manner
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - May 7, 2019 Category: Neuroscience Authors: Won Jin Lee, Sun Ah Ham, Gyeong Hee Lee, Mi ‐Jung Choi, Hyunjin Yoo, Kyung Shin Paek, Dae‐Seog Lim, Kwonho Hong, Jung Seok Hwang, Han Geuk Seo Tags: Original Article Source Type: research

Copper and zinc ions govern the trans ‐directed dimerization of APP family members in multiple ways
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - May 7, 2019 Category: Neuroscience Authors: Alexander August, Nadine Schmidt, Johannes Klingler, Frederik Baumk ötter, Marius Lechner, Jessica Klement, Simone Eggert, Carolyn Vargas, Klemens Wild, Sandro Keller, Stefan Kins Tags: Original Article Source Type: research

What is the extracellular calcium concentration within brain synapses?
Calcium (Ca2+) is essential for the normal functioning of the brain and Ca2+ influx depends on the gradient for this ion across the plasma membrane, and slight fluctuations of extracellular Ca2+ concentration have significant impact on axonal excitability, synaptic transmission, and plasticity. This Editorial highlights the work by Forsberget  al. who report a concentration of physiologically active Ca2+ in human cerebrospinal fluid (CSF) that is half of that normally used in artificial CSF in electrophysiological brain slice experiments. We now discuss these new findings in the context of the spatial organization of ...
Source: Journal of Neurochemistry - May 6, 2019 Category: Neuroscience Authors: Jo ão Pedro Lopes, Rodrigo A. Cunha Tags: Editorial Highlight Source Type: research

Antibodies against alpha ‐synuclein: tools and therapies
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - May 4, 2019 Category: Neuroscience Authors: Nishant N. Vaikath, Issam Hmila, Vijay Gupta, Daniel Erskine, Martin Ingelsson, Omar M. A. El ‐Agnaf Tags: Review Source Type: research

Autophagic degradation of STIM2 mediates disruption of neuronal dendrites by ER stress
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 30, 2019 Category: Neuroscience Authors: Jing Zhou, Juan Song, Shengzhou Wu Tags: Original Article Source Type: research

Metabolic constraints of swelling ‐activated glutamate release in astrocytes and their implication for ischemic tissue damage
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 29, 2019 Category: Neuroscience Authors: Corinne S. Wilson, Martin D. Bach, Zahra Ashkavand, Kenneth R. Norman, Nina Martino, Alejandro P. Adam, Alexander A. Mongin Tags: Original Article Source Type: research

Corrigendum
Journal of Neurochemistry, Volume 149, Issue 3, Page 427-427, May 2019. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 25, 2019 Category: Neuroscience Tags: Corrigendum Source Type: research

Issue Information
Journal of Neurochemistry, Volume 149, Issue 3, Page 311-316, May 2019. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 25, 2019 Category: Neuroscience Tags: Issue Information Source Type: research

Issue Cover (May 2019)
Front cover:Amyloid precursor protein (APP) is processed to form the amyloid ‐β (Aβ) which is a key component in the initiation of Alzheimer‘s disease. Aβ is preferentially produced from the 695 isoform of APP indicating that the different isoforms are differentially processed and may have different interactomes that regulate their processing. Stable isotope labelling of amino acids in cell culture (SILAC) and quantitative proteomics identified different interactomes for the 695 and 751 isoforms of APP. These data identify new proteins that may be important in regulating Aβ production.Image cont...
Source: Journal of Neurochemistry - April 25, 2019 Category: Neuroscience Tags: Issue Cover Source Type: research

Proteomics; applications in familial Parkinson's disease
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 25, 2019 Category: Neuroscience Authors: Yan Li, Mark R Cookson Tags: Review Source Type: research

α‐synuclein oligomers enhance astrocyte‐induced synapse formation through TGF‐β1 signaling in a Parkinson's disease model
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 22, 2019 Category: Neuroscience Authors: Luan Pereira Diniz, Isadora Matias, Ana Paula B érgamo Araujo, Matheus N. Garcia, Fernanda Barros Aragão, Soniza Vieira Alves‐Leon, Jorge Marcondes de Souza, Débora Foguel, Cláudia P. Figueiredo, Carolina Braga, Luciana Romão, Flávia Ca Tags: Original Article Source Type: research

Increasing carbohydrate availability in the hindgut promotes hypothalamic neurotransmitter synthesis: aromatic amino acids linking the microbiota ‐brain axis
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 21, 2019 Category: Neuroscience Authors: Kan Gao, Yu Pi, Chun ‐Long Mu, Aitak Farzi, Zhuang Liu, Wei‐Yun Zhu Tags: Original Article Source Type: research

In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategies
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 20, 2019 Category: Neuroscience Authors: Amir Tayaranian Marvian, David J. Koss, Farhang Aliakbari, Dina Morshedi, Tiago Fleming Outeiro Tags: Review Source Type: research

Differential regulation of phasic dopamine release in the forebrain by the VTA noradrenergic receptor signaling
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 18, 2019 Category: Neuroscience Authors: Micha ł Kiełbiński, Joanna Bernacka, Wojciech B. Solecki Tags: Original Article Source Type: research

Mitochondria ‐coupled glucose phosphorylation develops after birth to modulate H2O2 release and calcium handling in rat brain
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 18, 2019 Category: Neuroscience Authors: E. de ‐Souza‐Ferreira, I. M Rios‐Neto, E. L Martins, A. Galina Tags: Original Article Source Type: research

Issue Information
Journal of Neurochemistry, Volume 149, Issue 2, Page 161-167, April 2019. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 14, 2019 Category: Neuroscience Tags: Issue Information Source Type: research

Issue Cover (April 2019)
Front cover:Reductions in the sensitivity of the brain insulin receptor (IR) have been linked to the appearance of cognitive dysfunctions. This relationship has been demonstrated both by preclinical and clinical data and has been labelled as Type 3 Diabetes. It is believed to be the previous step to the appearance of sporadic or late ‐onset Alzheimer’s disease. The c‐Jun N‐terminal Kinases (JNK) are one of the many regulator of the IR. In order to investigate this mechanism, Mapk9 gene knock‐out transgenic mice (JNK2 knock‐out) together with a palmitic acid‐enriched diet (high‐fat diet; HFD) were used. ...
Source: Journal of Neurochemistry - April 14, 2019 Category: Neuroscience Tags: Issue Cover Source Type: research

Can we turn mice into men?
AbstractThe pressure to develop pharmacological therapeutic interventions in the field of the rapidly progressing, fatal disease amyotrophic lateral sclerosis (ALS) is traditionally high. Cannabinoids have been discussed for decades as potential neuroprotective agents for ALS because of their antiexcitatory, anti ‐inflammatory, antiapoptotic and anticatabolic properties. This Editorial highlights a study by Urbi et al in the current issue of the Journal of Neurochemistry, in which the authors performed a Systematic Review and come to the conclusion that cannabinoids seem to have a small, but consistent eff ect on surviva...
Source: Journal of Neurochemistry - April 14, 2019 Category: Neuroscience Authors: Albert C. Ludolph Tags: Editorial Highlight Source Type: research

Novel regulatory systems for acetylcholine release in rat striatum and anti ‐Alzheimer's disease drugs
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 10, 2019 Category: Neuroscience Authors: Ikunobu Muramatsu, Junsuke Uwada, Hatsumi Yoshiki, Kiyonao Sada, Kung ‐Shing Lee, Takashi Yazawa, Takanobu Taniguchi, Matomo Nishio, Takaharu Ishibashi, Takayoshi Masuoka Tags: Original Article Source Type: research

Extracellular and intracellular sphingosine ‐1‐phosphate distinctly regulates exocytosis in chromaffin cells
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 9, 2019 Category: Neuroscience Authors: Zhong ‐Jiao Jiang, Taylor L. Delaney, Mark P Zanin, Rainer V Haberberger, Stuart M Pitson, Jian Huang, Simon Alford, Stephanie Cologna, Damien J Keating, Liang‐Wei Gong Tags: Original Article Source Type: research

Release parameters during progressive degeneration of dopamine neurons in mouse model reveal earlier impairment of spontaneous than forced behaviors
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - April 1, 2019 Category: Neuroscience Authors: Yuan ‐Hao Chen, Tsung‐Hsun Hsieh, Tung‐Tai Kuo, Jen‐Hsin Kao, Kuo‐Hsing Ma, Eagle Yi‐Kung Huang, Yu‐Ching Chou, Lars Olson, Barry J. Hoffer Tags: Original Article Source Type: research

Neuroprotective effects of an engineered commensal bacterium in the 1 ‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine Parkinson disease mouse model via producing glucagon‐like peptide‐1
In this study, we developed a MG1363 ‐pMG36e‐GLP‐1 strain to continuously express GLP‐1, and found this strain had effectively alleviated the decrease in motor function and reduced the α‐Syn expression in mice brain caused by MPTP via increasing tyrosine hydroxylase (TH)‐positive neurons, suppressing microglia andastrocyte s activation, down‐regulating inflammatory factors expression, and regulating gut microbiota composition. Therefore, this strain can be served as a safe and effective agent for PD treatment. AbstractWhile glucagon ‐like peptide‐1 (GLP‐1) was reported to have a positive impact on...
Source: Journal of Neurochemistry - April 1, 2019 Category: Neuroscience Authors: Xin Fang, Puyuan Tian, Xiaoxiao Zhao, Chunling Jiang, Tingtao Chen Tags: Original Article Source Type: research

MicroRNA ‐135a‐5p reduces P2X7‐dependent rise in intracellular calcium and protects against excitotoxicity
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - March 29, 2019 Category: Neuroscience Authors: David Reigada, Andr és Ángel Calderón‐García, Manuel Soto‐Catalán, Manuel Nieto‐Díaz, Teresa Muñoz‐Galdeano, Ángela del Águila, Rodrigo M. Maza Tags: Original Article Source Type: research

l ‐3,4‐dihydroxyphenylalanine (l‐DOPA) modulates brain iron, dopaminergic neurodegeneration and motor dysfunction in iron overload and mutant alpha‐synuclein mouse models of Parkinson's disease
We examined the effects ofl‐DOPA in three murine models of parkinsonian neurodegeneration: early‐life Fe overexposure in wild‐type mice, transgenic human (h)A53T mutant α‐synuclein (α‐syn) over‐expression, and a combined ‘multi‐hit’ model of Fe‐overload in hA53T mice. We found thatl‐DOPA was neuroprotective and prevented age‐related Fe accumulation in the substantia nigra pars compacta (SNc), similar to the mild‐affinity Fe chelator clioquinol. Chronicl‐DOPA treatment showed no evidence of increased oxidative stress in wild‐type midbrain and normalized motor performance, wh...
Source: Journal of Neurochemistry - March 28, 2019 Category: Neuroscience Authors: Jessica L. Billings, Sarah L. Gordon, Tristan Rawling, Philip A. Doble, Ashley I. Bush, Paul A. Adlard, David I. Finkelstein, Dominic J. Hare Tags: Original Article Source Type: research

Issue Information
Journal of Neurochemistry, Volume 149, Issue 1, Page 1-8, April 2019. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - March 28, 2019 Category: Neuroscience Tags: Issue Information Source Type: research

Issue Cover (April 2019)
Front cover:The HIV ‐1 Tat (transactivator of transcription) protein causes rapid and significantly increased [Ca2+]i in oligodendrocytes (OLs). The increased [Ca2+]i injures/kills relatively immature OLs; mature OLs remain healthy. This discrepancy may relate to maturational differences in CaMKII β and GSK3β levels and interactions. Tat preferentially activated GSK3β in immature OLs, whose lower levels of CaMKIIβ were insufficient to limit the pro‐apoptotic signaling by GSK3β. Results suggest that increasing CaMKIIβ activity might limit OL/myelin injury associated with HIV infection.Image...
Source: Journal of Neurochemistry - March 28, 2019 Category: Neuroscience Tags: Issue Cover Source Type: research

Differential responses to increasing numbers of mild traumatic brain injury in a rodent closed ‐head injury model
This article has received a badge for *Open Materials* because it provided all relevant information to reproduce the study in the manuscript. The complete Open Science Disclosure form for this article can be found at the end of the article. More information about the Open Practices badges can be found athttps://cos.io/our-services/open-science-badges/.Open Science: This manuscript was awarded with the Open Materials BadgeFor more information see:https://cos.io/our-services/open-science-badges/ (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - March 27, 2019 Category: Neuroscience Authors: Brooke Fehily, Carole A. Bartlett, Stephen Lydiard, Michael Archer, Hannah Milbourn, Maimuna Majimbi, Jan M. Hemmi, Sarah A. Dunlop, Nathanael J. Yates, Melinda Fitzgerald Tags: Original Article Source Type: research

Role of brain c ‐Jun N‐terminal kinase 2 in the control of the insulin receptor and its relationship with cognitive performance in a high‐fat diet pre‐clinical model
In conclusion, HFD and JNK2 absence cause alterations in normal cognitive activity by altering the signalling of the IR. These af fectations are related to the appearance of endoplasmic reticulum stress and an increase in the levels of inhibitory proteins like PTP1B and suppressor of cytokine signalling 3 protein. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - March 27, 2019 Category: Neuroscience Authors: Oriol Busquets, Àuria Eritja, Blanca M. López, Miren Ettcheto, Patricia R. Manzine, Rubén D. Castro‐Torres, Ester Verdaguer, Jordi Olloquequi, Manuel Vázquez‐Carrera, Carme Auladell, Jaume Folch, Antoni Camins Tags: Original Article Source Type: research

Endogenous transient receptor potential ankyrin 1 and vanilloid 1 activity potentiates glutamatergic input to spinal lamina I neurons in inflammatory pain
This article has received a badge for *Open Materials* because it provided all relevant information to reproduce the study in the manuscript. The complete Open Science Disclosure form for this article can be found at the end of the article. More information about the Open Practices badges can be found athttps://cos.io/our-services/open-science-badges/.Open Science: This manuscript was awarded with the Open Materials BadgeFor more information see:https://cos.io/our-services/open-science-badges/ (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - March 26, 2019 Category: Neuroscience Authors: Yuying Huang, Shao ‐Rui Chen, Hong Chen, Hui‐Lin Pan Tags: Original Article Source Type: research

Tyrosine hydroxylase phosphorylation in  vivo
Tyrosine hydroxylase (TH) is the rate ‐limiting enzyme in catecholamine synthesis. Its activity is controlled by protein phosphorylation. This review summarises: The methods used to investigate TH phosphorylation and TH activationin  vivo. Thein  vivo evidence for: Which protein kinases phosphorylate TH? Which protein phosphatases dephosphorylate TH? What is the stoichiometry of pTH? What proteins bind to pTH? Where is pTH localised? What is the nature of TH regulation in different catecholaminergic cells? The time course of TH phosphorylationin  vivo in response to stressors activating major c...
Source: Journal of Neurochemistry - March 20, 2019 Category: Neuroscience Authors: Peter R. Dunkley, Phillip W. Dickson Tags: Review Source Type: research

Clinical and neuropathological differences between Parkinson's disease, Parkinson's disease dementia, and dementia with Lewy bodies – current issues and future directions
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - March 20, 2019 Category: Neuroscience Authors: Lauren Walker, Leonidas Stefanis, Johannes Attems Tags: Review Source Type: research

Regulation of T ‐type Ca2+ channel expression by interleukin‐6 in sensory‐like ND7/23 cells post herpes simplex virus (HSV‐1) infection
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - March 19, 2019 Category: Neuroscience Authors: Qiaojuan Zhang, Shao ‐Chung Hsia, Miguel Martin‐Caraballo Tags: Original Article Source Type: research

Understanding depression: the hippocampus might hold the answer in a CREB ‐regulated transcription coactivator
Schematic of the key findings reported by Niet  al. 2018. Breuillaudet  al. (2012) initially reported that deletion ofCrtc1 results in both decreased BDNF expression in the brain, and behavioral deficits, including depressive ‐like behaviors. Niet  al. (2018) manipulated CRTC1 expression specifically in the hippocampus via knockdown and over ‐expression approaches, and demonstrated the importance of hippocampal CRTC1 in LPS‐induced neuroinflammation and depressive‐like behaviors. This investigation revealed that CRTC1‐mediated increases in the expression of the neuropeptides BDNF and VGF in the hip...
Source: Journal of Neurochemistry - March 15, 2019 Category: Neuroscience Authors: Randall L. Davis Tags: Editorial Highlight Source Type: research

Effects of HIV ‐1 Tat on oligodendrocyte viability are mediated by CaMKIIβ–GSK3β interactions
The HIV ‐1 protein Tat (transactivator of transcription) is documented to cause significant neurotoxicity. We have reported that immature oligodendrocytes (OLs) are also quite vulnerable to toxic effects of HIV‐1 Tat, through Ca2+‐mediated mechanisms. More mature OLs experience similarly elevated [Ca2+]i but display significantly less cytotoxicity. Based on the findings presented here, we propose that this differential toxicity may reflect changes in the relative levels of GSK3 β versus CaMKIIβ as OLs mature. HIV‐1 Tat‐dependent increases in [Ca2+]i can activate both GSK3 β and CaMKIIβ. In mat...
Source: Journal of Neurochemistry - March 15, 2019 Category: Neuroscience Authors: Shiping Zou, Joyce M. Balinang, Jason J. Paris, Kurt F. Hauser, Babette Fuss, Pamela E. Knapp Tags: Original Article Source Type: research

Issue Information
Journal of Neurochemistry, Volume 148, Issue 6, Page 691-697, March 2019. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - March 12, 2019 Category: Neuroscience Tags: Issue Information Source Type: research

Issue Cover (March 2019)
Front cover:Venlafaxine is a serotonin and norepinephrine reuptake inhibitor that is commonly prescribed for individuals who suffer from major depressive disorder. A full understanding of how venlafaxine improves function in responsive individuals is unknown. In the present study, we tested the possibility that venlafaxine could attenuate perineuronal net (PNN) integrity and concomitantly increase the power of hippocampal gamma oscillations in ex vivo slices. The PNN is thought to facilitate the activity of parvalbumin ‐expressing, GABA‐releasing interneurons. We therefore posit that in the background of PNN diminution...
Source: Journal of Neurochemistry - March 12, 2019 Category: Neuroscience Tags: Issue Cover Source Type: research

Acknowledgement of Reviewers
Journal of Neurochemistry, Volume 148, Issue 6, Page 837-838, March 2019. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - March 12, 2019 Category: Neuroscience Tags: Acknowledgement of Reviewers Source Type: research

Ionized calcium in human cerebrospinal fluid and its influence on intrinsic and synaptic excitability of hippocampal pyramidal neurons in the rat
In conclusion, an increase from the physiological 1.2 mM to 2 mM calcium in the aCSF has striking effects on neuronal excitability, synaptic transmission and the induction of LTP.This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - March 9, 2019 Category: Neuroscience Authors: My Forsberg, Henrik Seth, Andreas Bj örefeldt, Tim Lyckenvik, Mats Andersson, Pontus Wasling, Henrik Zetterberg, Eric Hanse Tags: Original Article Source Type: research