Corrigendum.
Authors: PMID: 31508898 [PubMed - in process] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - September 13, 2019 Category: Hematology Tags: Int J Lab Hematol Source Type: research

Semi-automated von Willebrand factor multimer assay for von Willebrand disease: Further validation, benefits and limitations.
CONCLUSION: This easy to use, standardised, semi-automated multimer analysis system can demonstrate the multimer profile of VWD patients, thus representing an additional laboratory tool for improved diagnosis, thereby facilitating appropriate patient management. PMID: 31508897 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - September 11, 2019 Category: Hematology Authors: Oliver S, Vanniasinkam T, Mohammed S, Vong R, Favaloro EJ Tags: Int J Lab Hematol Source Type: research

Interference of lipemia in samples for routine coagulation testing using a Sysmex CS-5100 coagulometer.
CONCLUSIONS: For PT and antithrombin activity a mean percentual difference between the two determinations lower than within-subject biologic variation and one of the Fraser's quality specifications can be considered as a confounding 'noise' factor that is neither analytically nor clinically relevant. If the instrument determines a result on the first run, for PT, aPTT, D-dimer concentration and antithrombin activity tests, the double plasma high-speed centrifugation is unnecessary. It is instead necessary if fibrinogen>2 g/L or if the instrument cannot determine a result on the first run. PMID: 31508901 [PubMe...
Source: International Journal of Laboratory Hematology - September 11, 2019 Category: Hematology Authors: Negrini D, Bernardi D, Antonelli G, Plebani M Tags: Int J Lab Hematol Source Type: research

Machine learning applications in the diagnosis of leukemia: Current trends and future directions.
Abstract Machine learning (ML) offers opportunities to advance pathological diagnosis, especially with increasing trends in digitalizing microscopic images. Diagnosing leukemia is time-consuming and challenging in many areas globally and there is a growing trend in utilizing ML techniques for its diagnosis. In this review, we aimed to describe the literature of ML utilization in the diagnosis of the four common types of leukemia: acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), acute myeloid leukemia (AML), and chronic myelogenous leukemia (CML). Using a strict selection criterion, utilizing M...
Source: International Journal of Laboratory Hematology - September 9, 2019 Category: Hematology Authors: Salah HT, Muhsen IN, Salama ME, Owaidah T, Hashmi SK Tags: Int J Lab Hematol Source Type: research

Performance evaluation of a new Stago ® automated haemostasis analyser: The STA R Max® 2.
CONCLUSION: According to our methods validation's recommendations, the results demonstrated a good technical and analytical performance of the STA R Max® 2 analysers for the tests assessed. PMID: 31487100 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - September 5, 2019 Category: Hematology Authors: Cupaiolo R, Govaerts D, Blauwaert M, Cauchie P Tags: Int J Lab Hematol Source Type: research

Lupus anticoagulant diagnosis in patients receiving direct oral FXa inhibitors at trough levels: A real-life study.
Abstract INTRODUCTION: Direct oral factor Xa inhibitors (xabans) induce false positive results for lupus anticoagulant (LA) diagnosis. Consequently, it is suggested not to perform LA testing in xabans patients although it may be useful in selected patients. In this monocentric study, we evaluated xabans impact at trough levels (ie, just before the next intake) on LA diagnosis in treated patients using dilute Russell viper venom time (dRVVT) and two LA sensitive activated partial thromboplastin time (aPTT). METHODS: Sixty patients receiving rivaroxaban (30) or apixaban (30) were included. Plasma concentrations...
Source: International Journal of Laboratory Hematology - September 5, 2019 Category: Hematology Authors: Gay J, Duchemin J, Imarazene M, Fontenay M, Jourdi G Tags: Int J Lab Hematol Source Type: research

A novel SERPINC1 frameshift mutation in two antithrombin deficiency families.
PMID: 31441586 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - August 23, 2019 Category: Hematology Authors: Zhang D, Sun B, Zhang X, Li H, Lin Y, Qin L, Chen L, Zhang L, Ru K, Yang R Tags: Int J Lab Hematol Source Type: research

A novel JAK2 R564* variant in a patient with thrombocytosis.
PMID: 31441587 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - August 23, 2019 Category: Hematology Authors: Villanueva A, Poon KS, Gallardo CA, Chai CN, Chiu L, Yan B, Ding CSL, Yong KJ, Zhou J, Lee J, Tan K, Ong KH Tags: Int J Lab Hematol Source Type: research

Low neutrophil side scatter in chronic kidney disease: An Indian study.
PMID: 31441597 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - August 23, 2019 Category: Hematology Authors: Shekhar R, Pai S Tags: Int J Lab Hematol Source Type: research

Low expression of TET2 gene in pediatric acute lymphoblastic leukemia is associated with poor clinical outcome.
CONCLUSION: Low expression of TET2 in children with ALL is associated with poor prognosis and can be used as a molecular prognostic marker for risk group stratification. PMID: 31441600 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - August 23, 2019 Category: Hematology Authors: Zhang P, Weng WW, Chen P, Zhang Y, Ruan JF, Ba DD, Xu WQ, Tang YM Tags: Int J Lab Hematol Source Type: research

Establishment of reference intervals for complete blood count parameters in venous blood for children in the Xiamen area, China.
CONCLUSIONS: There are dynamic variations in the values reported for measurements of most CBC parameters in children. Hence, such results should always be interpreted according to the child's age. Thus establishing appropriate RIs for different age groups in paediatrics is essential. PMID: 31424150 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - August 19, 2019 Category: Hematology Authors: Li J, Zhang H, Huang X, Zhang J, Wu X Tags: Int J Lab Hematol Source Type: research

Paediatric reference intervals for common coagulation assays in Chinese children as performed on the STA-R coagulation analyzer.
In this study, a total of 34 234 apparently healthy children and adolescents aged 0-15 years were chosen as reference individuals. PT, TT, aPTT and Fg were performed on the STA-R coagulation analyzer. Outliers were eliminated using the Dixon D/R ratio rule. Partitioning by age was achieved using Harris and Boyd's standard normal deviate test. The lower (2.5th percentiles) and upper (97.5 percentiles) reference intervals were established using the nonparametric method. RESULTS: Compared with the adult group, the median time of PT was significantly different in the groups consisting of children aged 0-15 ...
Source: International Journal of Laboratory Hematology - August 19, 2019 Category: Hematology Authors: Liu J, Dai Y, Yuan E, Li Y, Wang Q, Wang L, Su Y Tags: Int J Lab Hematol Source Type: research

Harlequin cell: Ubiquitous or pathognomic?
PMID: 31424608 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - August 19, 2019 Category: Hematology Authors: Jain G, Kumar C, Chopra A Tags: Int J Lab Hematol Source Type: research

How I investigate bone marrow necrosis.
Abstract Hematopathologists encounter bone marrow biopsy specimens with marrow necrosis relatively infrequently; when necrosis is seen, determining the clinical significance can be challenging. While bone marrow necrosis is not uncommon in site-directed biopsy specimens or autopsy material, substantial necrosis is much less common in nondirected bone marrow biopsy specimens. Retrospective review showed the prevalence of bone marrow necrosis to vary between 0.3% and 2% antemortem, depending on the patient population. Numerous causes of bone marrow necrosis have been identified, including malignancy, radiation/chemo...
Source: International Journal of Laboratory Hematology - August 19, 2019 Category: Hematology Authors: Deucher A, Wool GD Tags: Int J Lab Hematol Source Type: research

A cost-effective approach to factor assay calibration using a truncated live calibration curve.
CONCLUSION: To the best of our knowledge, this is the first study that demonstrates that the use of a live truncated calibration curve will improve precision and accuracy. PMID: 31421012 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - August 17, 2019 Category: Hematology Authors: Guy S, Sermon-Cadd AM, Shepherd FM, Kitchen S, Bowyer AE Tags: Int J Lab Hematol Source Type: research

The hypercoagulable state in multiple myeloma: The contribution of thrombin generation test.
CONCLUSION: Thrombin generation appears to be higher in patients with myeloma compared with controls, especially in high-risk patients, and does not change significantly after treatment completion. PMID: 31421013 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - August 17, 2019 Category: Hematology Authors: Baccouche H, Hadhri M, Aissi W, Chakroun A, Bahri D, Mahjoub S, Ben Romdhane N Tags: Int J Lab Hematol Source Type: research

Relationship of thromboelastography and conventional clotting test values with severe bleeding in critically ill patients with coagulopathy: A prospective study.
CONCLUSIONS: Both conventional clotting tests and TEG values were poorly associated with bleeding in this critically ill cohort of patients with coagulopathy. PMID: 31403249 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - August 12, 2019 Category: Hematology Authors: Casado-Méndez M, Fernandez-Pacheco J, Arellano-Orden V, Rodríguez-Martorell FJ, Díaz-Martín A, Pastor de Las Heras Á, Dusseck-Brutus R, Pérez-Torres I, Leal-Noval SR Tags: Int J Lab Hematol Source Type: research

Characterization of myeloid malignancies with TP53 mutations and comparison to P53 expression by immunohistochemical staining methods.
PMID: 31390152 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - August 7, 2019 Category: Hematology Authors: Karner KH, Kohan JL, Tripp SR, Salama ME Tags: Int J Lab Hematol Source Type: research

Performance evaluation of the prototype Abbott Alinity hq  hematology analyzer.
Performance evaluation of the prototype Abbott Alinity hq hematology analyzer. Int J Lab Hematol. 2019 Aug;41(4):448-455 Authors: Van der Beken Y, Van Dalem A, Van Moer G, Segers E, Damiaens S, Hoffmann J, Lakos G, Jochmans K Abstract INTRODUCTION: The analytical and clinical performance as well as the workflow efficiency of the novel, prototype Alinity hq hematology analyzer was evaluated in the clinical laboratory of Universitair Ziekenhuis Brussel, Department of Hematology, Brussels, Belgium. METHODS: Within-run and within-laboratory imprecision, linearity, and carryover were assessed usi...
Source: International Journal of Laboratory Hematology - July 17, 2019 Category: Hematology Authors: Van der Beken Y, Van Dalem A, Van Moer G, Segers E, Damiaens S, Hoffmann J, Lakos G, Jochmans K Tags: Int J Lab Hematol Source Type: research

The role of immature platelet fraction (IPF%) in full-term and preterm infants: Italian data of a promising clinical biomarker in neonates.
PMID: 31298786 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - July 12, 2019 Category: Hematology Authors: Garofoli F, Ciardelli L, Angelini M, Gentile R, Mazzucchelli I, Tinelli C, Bollani L, Tzialla C Tags: Int J Lab Hematol Source Type: research

Interlaboratory validation of apixaban levels in ex vivo patient samples using a chromogenic anti-factor Xa assay.
PMID: 31286666 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - July 9, 2019 Category: Hematology Authors: Singh J, Ong DM, Ling V, Lim MS, Malan E, Servadei P, Wallis A, Kelsey G, Chunilal S, Tran H Tags: Int J Lab Hematol Source Type: research

Clinical performance evaluation of the new hematology analyzer Mindray BC-6000.
Abstract INTRODUCTION: With the progression of blood analysis technology, hematology analyzers become more complex and diverse. How to choose a superb instrument is a challenge for the laboratories. In the essay, we studied whether the newest BC-6000 hematology analyzer meets the needs of a clinical hematology laboratory. METHODS: Methods comparison was performed using 350 blood samples from patients between different measurement procedures; the basic analytical performance was also tested, including the throughput, carryover, precision, and linearity in different modes. The flagging performances for blasts, ...
Source: International Journal of Laboratory Hematology - July 9, 2019 Category: Hematology Authors: Shen Y, Cao J, Zhou Z, Wang Y, Shen Y, He J Tags: Int J Lab Hematol Source Type: research

Newborn hereditary elliptocytosis confirmed by familial genetic testing.
PMID: 31286676 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - July 9, 2019 Category: Hematology Authors: Liu C, Eun HS, Nah H, Lee ST, Choi JR, Kim HO Tags: Int J Lab Hematol Source Type: research

Development and implementation of an expert rule set for automated reflex testing and validation of routine coagulation tests in a large pathology network.
CONCLUSION: The process was generally well received and generally beneficial to most laboratories in the network. PMID: 31271498 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - July 4, 2019 Category: Hematology Authors: Mohammed S, Ule Priebbenow V, Pasalic L, Favaloro EJ Tags: Int J Lab Hematol Source Type: research

Full blood count and white cell differential count reference ranges obtained from a healthy urban South African population residing in the Western Cape of South Africa.
Abstract BACKGROUND: Research has suggested that individuals of African descent have lower white cell and neutrophil counts than Caucasians. These differences could lead to incorrect clinical decisions, and therefore, ethnic-specific reference ranges are required. The Western Cape region of South Africa is uniquely diverse, comprising Caucasian, Mixed Ancestry and those of African descent. The aim of this study was to compare the full blood count and differential counts across the three major ethnic groups residing in this area and to propose appropriate RIs. METHODS: The study formed part of the internationa...
Source: International Journal of Laboratory Hematology - July 4, 2019 Category: Hematology Authors: Smit FC, Davison GM, Hoffmann M, Erasmus RT, Davids S, Matsha TE Tags: Int J Lab Hematol Source Type: research

Molecular prevalence of thalassemia and hemoglobinopathies among the Lao Loum Group in the Lao People's Democratic Republic.
CONCLUSION: Our data show that thalassemias and hemoglobinopathies have become health problems imposing a serious burden in the Lao PDR. Prevention programs aimed at decreasing the incidence of severe thalassemia diseases should be designed and initiated. PMID: 31271507 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - July 4, 2019 Category: Hematology Authors: Phanmany S, Chanprasert S, Munkongdee T, Svasti S, Leecharoenkiat K Tags: Int J Lab Hematol Source Type: research

Performance evaluation of Revohem ™ FVIII chromogenic and Revohem™ FIX chromogenic in the CS-5100 autoanalyser.
In this study, we evaluated the performance of these reagents in the CS-5100 automated coagulation analyser. METHODS: We assessed within-run and between-day imprecision, on-board stability and frozen-storage stability of Revohem FVIII and FIX. Sensitivity to lupus anticoagulant (LA) was examined using LA-positive patient plasma. Correlations were analysed using plasma samples from normal individuals and patients with haemophilia A (HA) or B (HB) or von Willebrand disease (VWD). RESULTS: Imprecision was
Source: International Journal of Laboratory Hematology - July 4, 2019 Category: Hematology Authors: Suzuki A, Suzuki N, Kanematsu T, Shinohara S, Arai N, Kikuchi R, Matsushita T Tags: Int J Lab Hematol Source Type: research

Performance evaluation of new Abbott Alinity hq hematology analyzer.
CONCLUSION: We performed initial validation studies and confirmed performance specifications on specimen stability, precision, linearity, carry-over, and method comparison. The Abbott Alinity hq analyzer showed good analytical performance for all standard CBC parameters. PMID: 31271528 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - July 4, 2019 Category: Hematology Authors: Woo KS, Jeong IH, An GD, Lim HH, Han JY Tags: Int J Lab Hematol Source Type: research

A case of reactive erythrocytosis with CD34/CD61 dual positive megakaryocytes.
PMID: 31241857 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - June 26, 2019 Category: Hematology Authors: Kim HN, Hur M, Kim H, Moon HW, Yun YM, Lee MH Tags: Int J Lab Hematol Source Type: research

Red blood cell distribution width has higher diagnostic performance in microcytic anemia when expressed in "absolute" units.
Red blood cell distribution width has higher diagnostic performance in microcytic anemia when expressed in "absolute" units. Int J Lab Hematol. 2019 Jun 21;: Authors: Hoffmann JJML, Urrechaga E PMID: 31225697 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - June 21, 2019 Category: Hematology Authors: Hoffmann JJML, Urrechaga E Tags: Int J Lab Hematol Source Type: research

Digital droplet PCR-based chimerism analysis for monitoring of hematopoietic engraftment after allogeneic stem cell transplantation.
CONCLUSION: According to our data, chimerism analysis by ddPCR has an excellent correlation with STR-based analyses. Due to its fast and easy applicability, the ddPCR technique is suitable for chimerism monitoring in clinical practice. PMID: 31225701 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - June 21, 2019 Category: Hematology Authors: Mika T, Baraniskin A, Ladigan S, Wulf G, Dierks S, Haase D, Schork K, Turewicz M, Eisenacher M, Schmiegel W, Schroers R, Klein-Scory S Tags: Int J Lab Hematol Source Type: research

Combined deficiency of factors V and VIII in a Chinese family due to a novel nonsense mutation in lectin mannose binding protein 1.
PMID: 31162802 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - June 4, 2019 Category: Hematology Authors: Deng J, Li D, Mei H, Tang L, Wang HF, Hu Y Tags: Int J Lab Hematol Source Type: research

Blast flagging of the Sysmex XN-10 hematology analyzer with supervised cell image analysis: Impact on quality parameters.
Abstract INTRODUCTION: The Sysmex XN-10 automated hematology analyzer (Sysmex Corporation) is routinely used in hematology laboratories to perform complete blood cell count with differential (CBC w/ diff). The sensitivity of this system for blast detection is unclear, since many prior studies evaluating the blast flagging capabilities of Sysmex XN series used the white precursor cell (WPC) channel, which is not cleared for use in the United States. METHODS: We assessed the blast flagging capabilities of the Sysmex XN-10 compared with CellaVision (a cell image analyzer)-assisted visual hematology results. We e...
Source: International Journal of Laboratory Hematology - June 4, 2019 Category: Hematology Authors: Petrone J, Jackups R, Eby CS, Shimer G, Anderson J, Frater JL Tags: Int J Lab Hematol Source Type: research

The applicability of multiparameter flow cytometry for the detection of minimal residual disease using different-from-normal panels to predict relapse in patients with acute myeloid leukemia after allogeneic transplantation.
Abstract BACKGROUND: The MRD status detected using multiparameter flow cytometry (MFC) before allogeneic hematopoietic stem cell transplantation (allo-HSCT) has crucial prognostic value for patients with acute myeloid leukemia (AML) in morphologic complete remission (CR). We designed a novel panel of antibodies to identify aberrant differentiation/maturation profiles of residual leukemia cells in patients who were not diagnosed at our institution, relapsed with an antigenic shift, or lack leukemia-associated immunophenotypes. METHODS: We compared the MRD status detected using MFC and real-time quantitative po...
Source: International Journal of Laboratory Hematology - June 4, 2019 Category: Hematology Authors: Wang Z, Guo M, Zhang Y, Xu S, Cheng H, Wu J, Zhang W, Hu X, Yang J, Wang J, Tang G Tags: Int J Lab Hematol Source Type: research

Polymorphisms in MAPK9 (rs4147385) and CSF1R (rs17725712) are associated with the development of inhibitors in patients with haemophilia A in North China.
CONCLUSION: We confirmed an association of CSF1R rs17725712 and MAPK9 rs4147385 with inhibitor development in haemophilia A patients in North China. PMID: 31149782 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - May 31, 2019 Category: Hematology Authors: Zhao M, Zhang Y, Liu Y, Sun G, Tian H, Hong L Tags: Int J Lab Hematol Source Type: research

Investigation of screening method for DNMT3A mutations by high-resolution melting analysis in acute myeloid leukemia.
CONCLUSION: High-resolution melting analysis has sufficient performance for the detection of DNMT3A mutations in AML. This approach can facilitate rapid AML genotyping at diagnosis in clinical settings. PMID: 31149783 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - May 31, 2019 Category: Hematology Authors: Mizuta S, Yamane N, Komai T, Koba Y, Kawata T, Ukyo N, Tamekane A, Watanabe M Tags: Int J Lab Hematol Source Type: research

Factor XIII Deficiency in Western Afghanistan due to a Novel F13A Gene Mutation.
PMID: 31136071 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - May 28, 2019 Category: Hematology Authors: Mousavi SH, Zeinali S, Mesbah-Namin SA, Shams M, Dorgalaleh A Tags: Int J Lab Hematol Source Type: research

Concurrent hematoma and venous thrombosis in a patient with autoimmune acquired factor XIII deficiency.
PMID: 31132215 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - May 27, 2019 Category: Hematology Authors: Tang N, Li D, Wang X, Yang J Tags: Int J Lab Hematol Source Type: research

Bone marrow findings in metastatic melanoma, including role of BRAF immunohistochemistry.
CONCLUSIONS: Features including cytopenias (typically anemia), leukoerythroblastosis, and morphology of cohesive, large atypical cells in aspirate and biopsy, and immunohistochemical expression for S100, Melan A, and HMB45 were present in patients with metastatic melanoma. BRAF V600E immunohistochemistry is useful as a surrogate marker of molecular results. Regardless of clinical history, at the time of the bone marrow biopsies, hematologic malignancies are in the main differential diagnosis and very rarely included metastatic melanoma, likely due to the under-recognized metastatic potential of melanoma to the bone marrow....
Source: International Journal of Laboratory Hematology - May 21, 2019 Category: Hematology Authors: Corean JLE, George TI, Patel JL, Li KD Tags: Int J Lab Hematol Source Type: research

Chromosomal microarray analysis is superior in identifying cryptic aberrations in patients with acute lymphoblastic leukemia at diagnosis/relapse as a single assay.
CONCLUSION: Incorporation of CMA as a routine clinical test at the time of diagnosis/relapse, in conjunction with CC and/or FISH, is highly recommended. PMID: 31112375 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - May 21, 2019 Category: Hematology Authors: Chen C, Heng EYH, Lim AST, Lau LC, Lim TH, Wong GC, Tien SL Tags: Int J Lab Hematol Source Type: research

"Bone marrow aspirate automated counts on hematology analyzers: formulating a scoring system based on hematology parameters, to discriminate reactive versus myelodysplastic syndrome-related bone marrows".
CONCLUSION: Automated BM counts on hematology analyzers contributed to the formulation of a SS for the screening discrimination between reactive and MDS BM fluids, which seems to be applicable and informative, regardless of the analyzer used. PMID: 31102331 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - May 18, 2019 Category: Hematology Authors: Tsagarakis NJ, Paterakis G, Papadhimitriou SI, Kritikou-Griva E, Goumakou E, Oudatzis G, Theodorakos I, Vasileiou P Tags: Int J Lab Hematol Source Type: research

Cytogenetics and associated mutation profile in patients with acute monocytic leukemia.
CONCLUSION: There was a significantly different mutation profile between KMT2Ar-patients and NK patients. Our research provided new insight into the molecular characteristics of AML-M5. PMID: 31099482 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - May 17, 2019 Category: Hematology Authors: Xing S, Wang B, Gao Y, Li M, Wang T, Sun Y, Shen Y, Chao H Tags: Int J Lab Hematol Source Type: research

Erythrocyte indices in a large cohort of β-thalassemia carrier: Implication for population screening in an area with high prevalence and heterogeneity of thalassemia.
Erythrocyte indices in a large cohort of β-thalassemia carrier: Implication for population screening in an area with high prevalence and heterogeneity of thalassemia. Int J Lab Hematol. 2019 May 17;: Authors: Singha K, Taweenan W, Fucharoen G, Fucharoen S Abstract INTRODUCTION: Most β-thalassemia carriers have hypochromic microcytosis with mean corpuscular volume (MCV) 
Source: International Journal of Laboratory Hematology - May 17, 2019 Category: Hematology Authors: Singha K, Taweenan W, Fucharoen G, Fucharoen S Tags: Int J Lab Hematol Source Type: research

Consistency and reproducibility in the platelet-rich plasma preparation method: Mexican experience.
-Almaguer D PMID: 31095867 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - May 16, 2019 Category: Hematology Authors: Ancer-Arellano J, Villarreal-Martinez L, Vazquez-Martínez O, Villarreal-Martinez A, Rodriguez-Mosqueda NL, Yamallel-Ortega LA, López-Olmos PA, Chavez-Alvarez S, Villarreal-Villarreal CD, Ocampo-Candiani J, Salazar-Riojas R, Gomez-Almaguer D Tags: Int J Lab Hematol Source Type: research

Flow cytometry "Ogata score" for the diagnosis of myelodysplastic syndromes in a real-life setting. A Latin American experience.
CONCLUSIONS: The diagnostic power found in this study was similar to the reported by Della-Porta et al. Also in LA, the analysis was made in modern equipment with acquisition of at least 100 000 events which permits a good reproducibility of the results. PMID: 31066993 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - May 8, 2019 Category: Hematology Authors: Grille Montauban S, Hernandez-Perez CR, Velloso EDRP, Novoa V, Lorand-Metze I, Gonzalez J, Solari L, Cismondi V, Serrano JC, Burgnini A, Rabelo-Carrasco LJ, Bacal N, Trias N, Guevara R, Rico Vido J, Crisp R, Enrico A, Boada M, Pereira Cunha FG, Fanessi V, Tags: Int J Lab Hematol Source Type: research

Monosomal karyotypes apart from complex karyotypes independently predict the outcome of myelodysplastic syndrome patients using a fluorescence in situ hybridization panel and conventional cytogenetics.
Abstract INTRODUCTION: The aim of the study was to analyze monosomal karyotype (MK) occurrence and the relationship between MKs and complex karyotypes (CKs) and to determine the prognostic significance of MKs in MDS patients based on conventional cytogenetic (CC) and fluorescence in situ hybridization (FISH) analyses. METHODS: CC and FISH analyses were conducted for 216 primary MDS patients. Follow-ups and statistical analysis were conducted. RESULTS: A total of 25 (11.6%) patients with MKs were identified by FISH and CC analyses, and 23 (92%) of these MKs were also CKs. Only 19 patients (8.8%) with MKs ...
Source: International Journal of Laboratory Hematology - May 8, 2019 Category: Hematology Authors: Wang N, Xu H, Li Q, Liu J, Sui X, Jiang Y, Fang X, Zhen C, Ding M, Yuan D, Zhang L, Wang X Tags: Int J Lab Hematol Source Type: research

Establishing a reference range for thromboelastograph parameters in the neonatal period.
CONCLUSION: This study preliminarily establishes a reference range for TEG parameters during the neonatal period. The age of a newborn had a large influence on TEG parameters. Additionally, we demonstrated a correlation between laboratory tests and TEG parameters for this age period. The reference values provided herein are meaningful for future studies. PMID: 31062936 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - May 7, 2019 Category: Hematology Authors: Liu Q, Xu C, Chen X, Wang J, Ke Z, Hu H Tags: Int J Lab Hematol Source Type: research

Do we still need morphologic evaluation in new era of advanced minimal residual disease analyses?
PMID: 31050862 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - May 3, 2019 Category: Hematology Authors: Yoon S, Kim H, Hur M, Han SH, Chung HJ, Moon HW, Yun YM, Lee MH Tags: Int J Lab Hematol Source Type: research

Comparison of real-time PCR vs PCR with fragment length analysis for the detection of CALR mutations in suspected myeloproliferative neoplasms.
PMID: 31050873 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - May 3, 2019 Category: Hematology Authors: Doyle LJ, Betz BL, Weigelin HC, Procop GW, Cook JR Tags: Int J Lab Hematol Source Type: research

Timeline of heparin-induced thrombocytopenia seroconversion in serial plasma samples tested using an automated latex immunoturbidimetric assay.
CONCLUSION: The LIA detects HIT antibodies at the beginning of the HIT-associated platelet count fall. The LIA was also positive in a patient with SRA-negative HIT. PMID: 31050876 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - May 3, 2019 Category: Hematology Authors: Warkentin TE, Sheppard JI, Smith JW, Arnold DM, Nazy I Tags: Int J Lab Hematol Source Type: research