Outcomes in patients with nontriple antiphospholipid syndrome (APS) anticoagulated with rivaroxaban.
PMID: 33470532 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - January 20, 2021 Category: Hematology Authors: Htut TW, Milne D, Khan MM, Watson HG Tags: Int J Lab Hematol Source Type: research

A novel SLC4A1 splice variant (c.2655+2_2655+3 del) in hereditary spherocytosis.
PMID: 33470548 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - January 20, 2021 Category: Hematology Authors: Kima ED, Mugnaini EN, Nava VE Tags: Int J Lab Hematol Source Type: research

Glutathione S-transferase gene polymorphic sequence variations: Association with risk and response to Imatinib among Chronic Myeloid Leukemia patients of Kashmir.
Abstract INTRODUCTION: Glutathione S-transferase (GST) gene deletion or polymorphic sequence variations lead to decreased enzyme activity that influences susceptibility and response to tyrosine kinase inhibitors in chronic myeloid leukemia (CML). We aimed to analyze relation of different GST gene sequence variants with susceptibility and response to Imatinib in CML. MATERIAL AND METHODS: A total of 150 CML cases and equal number of age and gender matched healthy controls were genotyped for five GST polymorphisms by multiplex-PCR and PCR-RFLP techniques. BCR-ABL1 transcripts were quantified by quantitativ...
Source: International Journal of Laboratory Hematology - January 20, 2021 Category: Hematology Authors: Baba SM, Shah ZA, Pandith AA, Geelani SA, Mir MM, Bhat JR, Gul A, Bhat GM Tags: Int J Lab Hematol Source Type: research

Features of serum complement C3 and C4 levels in autoimmune hemolytic anemia patients.
CONCLUSION: The study findings may be helpful in not only unraveling the mechanism underlying hemolysis in AIHA but also diagnosing AIHA and selecting targeted treatment strategies. PMID: 33459487 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - January 18, 2021 Category: Hematology Authors: Wang Z, Bo L, Xu Y, Liu H, Zhao Y Tags: Int J Lab Hematol Source Type: research

Performance evaluation of coaguchek pro II in comparison with coaguchek XS plus and sta-r Max using a sta-neoplastine CI plus.
CONCLUSION: Pro II INR values are accurate and reliable using both CB and VB; however, they should be confirmed by laboratory analyzers in the supratherapeutic range. PMID: 33460254 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - January 18, 2021 Category: Hematology Authors: Nam M, Hur M, Kim H, Yoon S, Lee S, Shin S, Moon HW, Yun YM Tags: Int J Lab Hematol Source Type: research

Revisiting the effects of spectral interfering substances in optical end-point coagulation assays.
CONCLUSIONS: Verification of the manufacturer's recommended interference thresholds is important since it may avoid inappropriate instrument flagging and/ or sample rejection. PMID: 33455065 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - January 17, 2021 Category: Hematology Authors: Seheult JN, Dalenberg D, Sridharan MR, Stuart M, Moericke K, Cardel L, Heikal N, Chen D, Pruthi RK Tags: Int J Lab Hematol Source Type: research

The relative expression levels of CD148 and CD180 on clonal B cells and CD148/CD180 median fluorescence intensity ratios are useful in the characterization of mature B cell lymphoid neoplasms infiltrating blood and bone marrow - Results from a single centre pilot study.
CONCLUSIONS: The current study shows an excellent utility of CD148MFI, CD180MFI, their ratio and relative expression levels in the subcategorization of immunophenotypically related MBNs. PMID: 33455071 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - January 17, 2021 Category: Hematology Authors: Gautam A, Sreedharanunni S, Sachdeva MUS, Rana S, Kashyap D, Bose P, Bal A, Prakash G, Malhotra P, Das R, Varma N Tags: Int J Lab Hematol Source Type: research

Serum Hevylite ® assay in the differential diagnosis of patients with high suspicion of AL Amyloidosis.
CONCLUSIONS: Hevylite® HLC analysis for Ig isotypes patterns offers an effective non-invasive tool in the evaluation of patients with high suspicion of AL and may assist further explorative decisions for diagnosis. PMID: 33455086 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - January 17, 2021 Category: Hematology Authors: Yogev D, Pick M, Slyusarevsky E, Pogrebijski G, Pickin A, Gatt ME Tags: Int J Lab Hematol Source Type: research

Urine immunofixation negativity is not necessary for complete response in intact immunoglobulin multiple myeloma: Retrospective real-world confirmation.
PMID: 33452712 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - January 16, 2021 Category: Hematology Authors: Radocha J, Jelinek T, Pour L, Spicka I, Minarik J, Popkova T, Jungova A, Pavlicek P, Brozova L, Stork M, Sedlak F, Krhovska P, Maisnar V, Heindorfer A, Sykora M, Wrobel M, Mikula P, Kessler P, Ullrychova J, Hajek R Tags: Int J Lab Hematol Source Type: research

Plasma hemoglobin: A method comparison of six assays for hemoglobin and hemolysis index measurement.
CONCLUSIONS: Plasma Hb and H-index results vary by method. Laboratories should evaluate the performance characteristics of their respective assays when considering adoption of spectrophotometric or chemical methods for plasma Hb assessment. PMID: 33449436 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - January 15, 2021 Category: Hematology Authors: Calvaresi EC, La'ulu SL, Snow TM, Allison TR, Genzen JR Tags: Int J Lab Hematol Source Type: research

Expression of CD304/neuropilin-1 in adult b-cell lymphoblastic leukemia/lymphoma and its utility for the measurable residual disease assessment.
Abstract INTRODUCTION: Many new markers are being evaluated to increase the sensitivity and applicability of multicolor flow cytometry (MFC)-based measurable residual disease (MRD) monitoring. However, most of the studies are limited to childhood B-cell lymphoblastic leukemia/lymphoma (B-ALL), and reports in adult B-ALL are extremely scarce and limited to small cohorts. We studied the expression of CD304/neuropilin-1 in a large cohort of adult B-ALL patients and evaluated its practical utility in MFC-based MRD analysis. METHODS: CD304 was studied in blasts from adult B-ALL patients and normal precursor B cell...
Source: International Journal of Laboratory Hematology - January 12, 2021 Category: Hematology Authors: Chatterjee G, Dudakia V, Ghogale S, Deshpande N, Girase K, Chaturvedi A, Shetty D, Senger M, Jain H, Bagal B, Bonda A, Punatar S, Gokarn A, Khattry N, Patkar NV, Gujral S, Subramanian PG, Tembhare PR Tags: Int J Lab Hematol Source Type: research

Bone marrow phagocytosis of gram-positive cocci in an infant.
PMID: 33433949 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - January 12, 2021 Category: Hematology Authors: Hu S, Sun P, Wen R Tags: Int J Lab Hematol Source Type: research

Relationship between thrombin generation parameters and prothrombin fragment 1  + 2 plasma levels.
Relationship between thrombin generation parameters and prothrombin fragment 1 + 2 plasma levels. Int J Lab Hematol. 2021 Jan 12;: Authors: Capecchi M, Scalambrino E, Griffini S, Grovetti E, Clerici M, Merati G, Chantarangkul V, Cugno M, Peyvandi F, Tripodi A PMID: 33433957 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - January 12, 2021 Category: Hematology Authors: Capecchi M, Scalambrino E, Griffini S, Grovetti E, Clerici M, Merati G, Chantarangkul V, Cugno M, Peyvandi F, Tripodi A Tags: Int J Lab Hematol Source Type: research

How I investigate minimal residual disease in acute lymphoblastic leukemia.
Abstract Minimal Residual Disease (MRD) is the most important independent prognostic factor in acute lymphoblastic leukemia (ALL) and refers to the deep level of measurable disease in cases with complete remission by conventional pathologic analysis, especially by cytomorphology. MRD can be detected by multiparametric flow cytometry, molecular approaches such as quantitative polymerase chain reaction for immunoglobulin and T-cell receptor (IG/TR) gene rearrangements or fusion genes transcript, and high-throughput sequencing for IG/TR. Despite the proven clinical usefulness in detecting MRD, these methods have diff...
Source: International Journal of Laboratory Hematology - January 10, 2021 Category: Hematology Authors: Correia RP, Bento LC, de Sousa FA, Barroso RS, Campregher PV, Bacal NS Tags: Int J Lab Hematol Source Type: research

CD44 enhances adriamycin resistance in chronic myelogenous leukaemia cells K562.
CONCLUSIONS: CD44 might be involved in adriamycin resistance via regulation of P-gp, MMP-2, MMP-9, and Bcl-2/Bax. PMID: 33411349 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - January 7, 2021 Category: Hematology Authors: Li J, Zhang Y, Cui Y, Jin H, Lin Z, Piao Y, Jin J Tags: Int J Lab Hematol Source Type: research

Cell count-based parameters and algorithms for thalassaemia trait screening in the southern Chinese population.
CONCLUSION: The proposed DFs performed well in the detection of TT among participants with microcytic and normocytic parameters and could be utilized in epidemiological study for TT. PMID: 33404202 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - January 6, 2021 Category: Hematology Authors: Xu J, Yang Y, Zhou H, Huang X, Chen B, Chen N, Wu Y Tags: Int J Lab Hematol Source Type: research

Identification of thalassemia gene cluster deletion by long-read whole-genome sequencing (LR-WGS).
CONCLUSION: Our results indicate that long-read WGS will be beneficial to the diagnosis of genetic diseases with pseudogenes or highly duplicated sequences and will enable clinical geneticists to inform high-risk couples and provide prenatal diagnosis. PMID: 33400392 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - January 5, 2021 Category: Hematology Authors: Jiang F, Lyu GZ, Zhang VW, Li DZ Tags: Int J Lab Hematol Source Type: research

High-throughput sequencing of immunoglobulin heavy chain for minimal residual disease detection in B-lymphoblastic leukemia.
CONCLUSION: We have developed a novel approach on high-sensitive assay for MRD detection in B-ALL, which could add clinical value in the management of patients, especially in cases negative for MRD by FC. PMID: 33393719 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - January 4, 2021 Category: Hematology Authors: Correia RP, Puga RD, Muto NH, Lee MLM, Torres DC, Hassan R, Bacal NS, Hamerschlak N, Campregher PV Tags: Int J Lab Hematol Source Type: research

Performance evaluation of the new hematology analyzer UniCel DxH 900.
CONCLUSION: UniCel DxH900 Coulter analyzer provides reliable results and fully comparable to DxH800. DxH900 is an accurate, highly precise analyzer with good analytical performances to be used effectively in high-volume laboratories. PMID: 33389827 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - January 2, 2021 Category: Hematology Authors: Martinez-Iribarren A, Tejedor X, Sala Sanjaume À, Leis A, Doladé Botias M, Morales-Indiano C Tags: Int J Lab Hematol Source Type: research

GATA1 mutation analysis and molecular landscape characterization in acute myeloid leukemia with trisomy 21 in pediatric patients.
CONCLUSIONS: The GATA1 mutations were reliably determined by fragment analysis and/or Sanger sequencing in a single PCR amplicon manner. For patients with extremely low blast counts and/or rare variants, the rapid screening with simple molecular approaches must be complemented with HTS. The JAK/STAT and RAS pathway-activating mutations may represent an extra option of targeted therapy with kinase inhibitors. PMID: 33386779 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - January 2, 2021 Category: Hematology Authors: Panferova A, Gaskova M, Nikitin E, Baryshev P, Timofeeva N, Kazakova A, Matveev V, Mikhailova E, Popov A, Kalinina I, Hachatrian L, Maschan A, Maschan M, Novichkova G, Olshanskaya Y Tags: Int J Lab Hematol Source Type: research

Study of thrombin generation with St Genesia to evaluate xaban pharmacodynamics: Analytical performances over 18  months.
Study of thrombin generation with St Genesia to evaluate xaban pharmacodynamics: Analytical performances over 18 months. Int J Lab Hematol. 2020 Dec 28;: Authors: Foulon-Pinto G, Jourdi G, Perrin J, Abdoul J, Paris G, Gouin-Thibault I, Curis E, Lecompte T, Siguret V Abstract INTRODUCTION: ST Genesia is a new automated system enabling quantitative standardized evaluation of thrombin generation (TG), for example, in patients receiving anti-Xa direct inhibitors (xabans). Data on its analytical performances are scarce. METHODS: Over an 18-month period, repeatability, reproducibility, and accurac...
Source: International Journal of Laboratory Hematology - December 28, 2020 Category: Hematology Authors: Foulon-Pinto G, Jourdi G, Perrin J, Abdoul J, Paris G, Gouin-Thibault I, Curis E, Lecompte T, Siguret V Tags: Int J Lab Hematol Source Type: research

Potential misdiagnosis of von Willebrand disease caused by insufficient mixing after thawing frozen plasma.
CONCLUSION: Thawed plasma should be mixed because of the risk of misdiagnosing vWD. Further education regarding the importance of appropriate mixing is warranted to achieve results comparable to those of freshly centrifuged samples. PMID: 33369143 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - December 27, 2020 Category: Hematology Authors: Jo SY, Kim IS, Kim H Tags: Int J Lab Hematol Source Type: research

CaMKII γ regulates the viability and self-renewal of acute myeloid leukaemia stem-like cells by the Alox5/NF-κB pathway.
In conclusion, our study describes a new role for CaMKIIγ as a stem-like cell marker that is highly regulated by the Alox5/NF-κB pathway in AML stem-like cells. CaMKIIγ can participate in the viability and self-renewal of AML stem-like cells by regulating the Alox5/NF-κB pathway. PMID: 33369192 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - December 25, 2020 Category: Hematology Authors: Cheng JH, Zhang WJ, Zhu JF, Cui D, Song KD, Qiang P, Mei CZ, Nie ZC, Ding BS, Han Z, Ding ZE, Zheng WW Tags: Int J Lab Hematol Source Type: research

The effect of freezing and thawing of samples for anti-factor Xa testing for the determination of enoxaparin activity.
PMID: 33369238 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - December 24, 2020 Category: Hematology Authors: Louw S, Gounden R, Vaughan J, Ntabeni L, Mayne A, Mayne ES Tags: Int J Lab Hematol Source Type: research

Identification and lineage restriction analyses of preleukemia cells in a sporadic biallelic CEBPA mutated acute myeloid leukemia patient.
PMID: 33369101 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - December 23, 2020 Category: Hematology Authors: Chen Y, Liu Q, Shi Z, Zhang G, Wang M, Mi Y, Wei H, Wang J Tags: Int J Lab Hematol Source Type: research

Predicting bacteraemia in maternity patients using full blood count parameters: A supervised machine learning algorithm approach.
CONCLUSION: The NLR should be considered for use in routine clinical practice when assessing the FBC result in patients with suspected bacteraemia during pregnancy or in the post-partum period. PMID: 33347714 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - December 21, 2020 Category: Hematology Authors: Mooney C, Eogan M, Ní Áinle F, Cleary B, Gallagher JJ, O'Loughlin J, Drew RJ Tags: Int J Lab Hematol Source Type: research

Blast size-specific flowcytometric ploidy assessment using FxCycleTM Violet dye and its correlation with conventional cytogenetic ploidy in pediatric precursor B-lineage acute lymphoblastic leukemia patients.
Abstract INTRODUCTION: Numerical chromosomal abnormalities (aneuploidies), present in approximately 30%-50% of pediatric precursor B-lineage acute lymphoblastic leukemia (B-ALL) patients, are commonly identified through a laborious conventional cytogenetic (CG) technique. Flow cytometry (FCM) can identify both physical and fluorescent properties of cells together, and by using fluorescent nucleic-acid-binding dyes, FCM can identify variations in total nucleic-acid content of cells. FxCycleTM Violet dye (FxCV) is a selective DNA-binding dye which permits simultaneous multiparametric immunophenotyping and cell-cycle...
Source: International Journal of Laboratory Hematology - December 20, 2020 Category: Hematology Authors: Bommannan K, Arumugam JR, Koshy T, Radhakrishnan V, Sagar TG, Sundersingh S Tags: Int J Lab Hematol Source Type: research

Purpura fulminans: How varicella zoster can result in acquired protein S deficiency.
PMID: 33342033 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - December 20, 2020 Category: Hematology Authors: Verbeke F, De Wilde B, Willems J, Devreese KMJ Tags: Int J Lab Hematol Source Type: research

How I investigate difficult cells at the optical microscope.
Abstract Blood cell morphological identification on the peripheral blood and bone marrow films remains a cornerstone for the diagnosis of hematological neoplasms to be integrated with immunophenotyping, molecular genetics, and histopathology. Although standardization is still far from being achieved, with high interobserver variability, in recent years, several classification approaches, from the 1976 FAB to the 2016 WHO classification, have provided hematologists with detailed morphological descriptions for a large number of diseases. Counting blasts and detecting dysplastic specimens are two cornerstones of morp...
Source: International Journal of Laboratory Hematology - December 20, 2020 Category: Hematology Authors: Zini G Tags: Int J Lab Hematol Source Type: research

Differential diagnosis of thalassemia and iron deficiency anemia using the CellaVision Advanced Red Blood Cell software.
CONCLUSION: Specific patterns of quantitative changes in RBC shapes were found in thalassemia and IDA patients. As a single parameter, target cell was the best morphological cell type to distinguish thalassemia from IDA, with an area under the curve (AUC) of 0.79, followed by hypochromatic cells with an AUC of 0.70. Combination of target and hypochromatic cells expressed as a ratio of the percentage of target cells to percentage of hypochromatic cells (T/H ratio) presented better differential diagnostic ability with an AUC of 0.88. A cutoff value of 1.755 for T/H ratio showed a sensitivity and specificity of 80.43% and 81....
Source: International Journal of Laboratory Hematology - December 20, 2020 Category: Hematology Authors: Wang F, Wang G, Yang Z, Wang X, Liu D, Wan N, Wu W Tags: Int J Lab Hematol Source Type: research

An assessment of the adequacy of iron deficiency anaemia management in the Namibian private healthcare system.
CONCLUSION: The study concluded that medical practitioners follow different guidelines and reference documents when dealing with patients with suspected IDA. Adherence to a single reference document would enable standardization of clinical practice. Management of IDA in the Namibian private healthcare system could be improved. To ensure adequate IDA management and prompt resolution of iron deficiency anaemia, we recommended the need to review the Namibia Standard Treatment guidelines and to ensure that training on the guidelines is offered. PMID: 33342069 [PubMed - as supplied by publisher] (Source: International Jour...
Source: International Journal of Laboratory Hematology - December 20, 2020 Category: Hematology Authors: Gonzo M, Nendongo A, Ephraim Mugweni K Tags: Int J Lab Hematol Source Type: research

Re: Full blood count reference intervals in the healthy population residing in the Cape Town region, South Africa.
PMID: 33340389 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - December 19, 2020 Category: Hematology Authors: de Koker A, Swart C, Rogerson J, Hilton C, Bird A, Opie J Tags: Int J Lab Hematol Source Type: research

Response to IJLH-07-20-0590. Full blood count reference intervals in the healthy population residing in the CapeTown region, South Africa.
PMID: 33340394 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - December 19, 2020 Category: Hematology Authors: Smit F, Davison GM, Hoffman M, Erasmus R, Davids S, Matsha T Tags: Int J Lab Hematol Source Type: research

A reduced panel of eight genes (ATM, SF3B1, NOTCH1, BIRC3, XPO1, MYD88, TNFAIP3, and TP53) as an estimator of the tumor mutational burden in chronic lymphocytic leukemia.
CONCLUSION: These results suggest that the eight gene estimator, that is easily achievable by high-throughput resequencing, brings robust and valuable information that predicts evolution of untreated patients at diagnosis better than any other parameter. PMID: 33325634 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - December 16, 2020 Category: Hematology Authors: Chauzeix J, Pastoret C, Donaty L, Gachard N, Fest T, Feuillard J, Rizzo D Tags: Int J Lab Hematol Source Type: research

Bilirubin crystals were detected in peripheral blood neutrophils in newborn with sepsis and G6PD deficiency.
PMID: 33314593 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - December 13, 2020 Category: Hematology Authors: Huang D, Tong H Tags: Int J Lab Hematol Source Type: research

U2AF1 expression is a novel and independent prognostic indicator of childhood T-lineage acute lymphoblastic leukemia.
CONCLUSION: Low U2AF1 mRNA level is related to inferior prognosis and can be served as a prognostic indicator for risk stratification in children with T-ALL. PMID: 33314767 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - December 13, 2020 Category: Hematology Authors: Zhang P, Zhang Y, Li X, Ying P, Tang Y Tags: Int J Lab Hematol Source Type: research

Mass-forming neoplastic extramedullary hematopoiesis mimics myeloid sarcoma in a patient with chronic phase chronic myeloid leukemia.
PMID: 33314782 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - December 13, 2020 Category: Hematology Authors: Hu Z, Singhi EK, Apostolidou E, Mai B, Juneja HS, Hu S Tags: Int J Lab Hematol Source Type: research

Downregulation of Lymphoid enhancer-binding factor 1 (LEF-1) expression (by immunohistochemistry and/ flow cytometry) in chronic Lymphocytic Leukemia with atypical immunophenotypic and cytologic features.
In this study, LEF-1 expression was assessed by two different techniques, (immunohistochemistry and flow cytometry), to investigate the expression profile of LEF-1 in cases of CLL/SLL, in comparison with other low-grade B-lymphomas and CLL with atypical features, including atypical immunophenotype and CLL with increased prolymphocytes or morphologically atypical cells. RESULTS: We found that LEF-1 expression is downregulated in CLL with atypical immunophenotype/features compared to classic CLL; Chi-Square P 
Source: International Journal of Laboratory Hematology - December 12, 2020 Category: Hematology Authors: Soliman DS, Al-Kuwari E, Siveen KS, Al-Abdulla R, Chandra P, Yassin M, Nashwan A, Hilmi FA, Taha RY, Nawaz Z, El-Omri H, Mateo JM, Al-Sabbagh A Tags: Int J Lab Hematol Source Type: research

Assessment of acquired activated protein C resistance with the FibWave and comparison with the ETP-based APC resistance.
CONCLUSION: The FibWave is able to differentiate APC resistance levels observed in women on combined oral contraceptive. The FW-Max1 , FW-Max2, and to a lesser degree FW-Min2 were identified as the most sensitive parameters with a similar performance to the ETP-based APC resistance assay. PMID: 33314736 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - December 12, 2020 Category: Hematology Authors: Evrard J, Morimont L, Didembourg M, Haguet H, Siriez R, Dogné JM, Douxfils J Tags: Int J Lab Hematol Source Type: research

Transient increase in blast count following COVID-19 infection mimicking acute leukemia.
PMID: 33314746 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - December 12, 2020 Category: Hematology Authors: Aladily TN, Alnahhal J, Alshorman A, Awidi A Tags: Int J Lab Hematol Source Type: research

Characterization of fibrin/fibrinogen degradation products reagents and their utility in critical care patients with enhanced fibrinolysis.
CONCLUSION: LIASAUTO P-FDP displayed the reactivity towards various fibrin/fibrinogen degradation products, and it might be useful for DIC diagnosis because the fibrinolytic status differed in the DIC types and stages. PMID: 33301236 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - December 10, 2020 Category: Hematology Authors: Kumano O, Ieko M, Komiyama Y, Naito S, Yoshida M, Takahashi N, Ohmura K, Hayakawa M Tags: Int J Lab Hematol Source Type: research

Green neutrophilic inclusions in meningococcal sepsis.
PMID: 33289959 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - December 8, 2020 Category: Hematology Authors: Shackleton L, Melotti D, Leddy C, Glavey S, Thornton P, Quinn J Tags: Int J Lab Hematol Source Type: research

Detection and significance of green inclusions in peripheral blood neutrophils and monocytes.
ipell M, Castro P PMID: 33289963 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - December 8, 2020 Category: Hematology Authors: Merino A, Molina A, Rodríguez-García M, Vicente-Steijn R, Tomé A, Maduell F, Xipell M, Castro P Tags: Int J Lab Hematol Source Type: research

Evaluation of eosinopenia as a diagnostic and prognostic indicator in COVID-19 infection.
CONCLUSIONS: Eosinopenia on admission is a reliable and convenient early diagnostic marker for COVID-19 infection, helping in early identification, triaging and isolation of the patients till nucleic acid test results are available. Role of eosinopenia as a prognostic indicator is insignificant. PMID: 33289964 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - December 8, 2020 Category: Hematology Authors: Soni M Tags: Int J Lab Hematol Source Type: research

Measurements of immature platelet fraction and inflammatory markers in atrial fibrillation patients - Does persistency or ablation affect results?
Abstract PURPOSE: Atrial fibrillation (AF) is associated with platelet hyperactivity and a higher proportion of immature platelets. We aimed to examine whether immature platelet fraction (IPF) and inflammatory markers differ between AF types and whether they are affected by ablation. METHODS: A prospective study included patients with atrial fibrillation/flutter (AFL). We excluded patients with hematologic, inflammatory, or acute coronary states. Blood samples for IPF, white blood cells (WBC), neutrophil-to-lymphocyte ratio (NLR), and C-reactive protein (CRP) were collected at baseline, within one-hour postab...
Source: International Journal of Laboratory Hematology - December 8, 2020 Category: Hematology Authors: Perelshtein Brezinov O, Sevylia Z, Rahkovich M, Kakzanov Y, Yahud E, Fortis L, Kogan Y, Asher E, Lev E, Laish-Farkash A Tags: Int J Lab Hematol Source Type: research

Thrombotic microangiopathy: A rare complication associated with medullar metastasis in solid cancer.
PMID: 33277964 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - December 5, 2020 Category: Hematology Authors: Montes L, Zerbib Y, Boyer T Tags: Int J Lab Hematol Source Type: research

CBFB gene rearrangement due to a novel t(1;16) with deceptive morphology.
PMID: 33275316 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - December 4, 2020 Category: Hematology Authors: Gupta A, Reddy KG Tags: Int J Lab Hematol Source Type: research

The characteristic peripheral blood morphological features of hospitalized patients infected with COVID-19.
PMID: 33270978 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - December 3, 2020 Category: Hematology Authors: Schapkaitz E, De Jager T, Levy B Tags: Int J Lab Hematol Source Type: research

ADAMTS13 activity to von Willebrand factor antigen ratio predicts acute kidney injury in patients with COVID-19: Evidence of SARS-CoV-2 induced secondary thrombotic microangiopathy.
Abstract INTRODUCTION: Severe COVID-19 is often compounded by a prothrombotic state that is associated with poor outcomes. In this investigation, we aimed to evaluate ADAMTS13 activity, von Willebrand factor level (VWF:Ag), and the corresponding ADAMTS13 activity/VWF:Ag ratio, in patients with COVID-19 and for associations with disease progression and acute kidney injury (AKI). METHODS: Patients presenting to the emergency department (ED) with COVID-19 were enrolled in this prospective, observational study. ADAMTS13 activity and VWF:Ag were measured at index ED visit. The primary endpoint was severe AKI defin...
Source: International Journal of Laboratory Hematology - December 3, 2020 Category: Hematology Authors: Henry BM, Benoit SW, de Oliveira MHS, Lippi G, Favaloro EJ, Benoit JL Tags: Int J Lab Hematol Source Type: research

Evaluation and comparison of the new Mindray BC-6200 hematology analyzer with ADVIA 2120i.
CONCLUSION: The new Mindray BC-6200 hematology analyzer provides high measurements precision and good correlation with ADVIA 2120i for most of the morphology and 5-diff parameters. PMID: 33270987 [PubMed - as supplied by publisher] (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - December 3, 2020 Category: Hematology Authors: Kulik K, Kwiecień I, Chełstowska B, Rutkowska E, Rzepecki P Tags: Int J Lab Hematol Source Type: research