Flow cytometric analysis of platelet function to detect high on-treatment residual platelet reactivity in patients on dual antiplatelet therapy
Int J Lab Hematol. 2021 Oct 21. doi: 10.1111/ijlh.13744. Online ahead of print.NO ABSTRACTPMID:34672087 | DOI:10.1111/ijlh.13744 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 21, 2021 Category: Hematology Authors: Li Li Dana Huskens Lisa Florin Bas de Laat Mark Roest Katrien M J Devreese Source Type: research

Flow cytometric analysis of platelet function to detect high on-treatment residual platelet reactivity in patients on dual antiplatelet therapy
Int J Lab Hematol. 2021 Oct 21. doi: 10.1111/ijlh.13744. Online ahead of print.NO ABSTRACTPMID:34672087 | DOI:10.1111/ijlh.13744 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 21, 2021 Category: Hematology Authors: Li Li Dana Huskens Lisa Florin Bas de Laat Mark Roest Katrien M J Devreese Source Type: research

Flow cytometric analysis of platelet function to detect high on-treatment residual platelet reactivity in patients on dual antiplatelet therapy
Int J Lab Hematol. 2021 Oct 21. doi: 10.1111/ijlh.13744. Online ahead of print.NO ABSTRACTPMID:34672087 | DOI:10.1111/ijlh.13744 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 21, 2021 Category: Hematology Authors: Li Li Dana Huskens Lisa Florin Bas de Laat Mark Roest Katrien M J Devreese Source Type: research

A comprehensive analysis of cytopenias and bone marrow morphology in patients with a history of bariatric and metabolic surgery
Int J Lab Hematol. 2021 Oct 20. doi: 10.1111/ijlh.13738. Online ahead of print.ABSTRACTINTRODUCTION: Following bariatric and metabolic surgery (BMS), patients may develop persistent cytopenia(s) despite adequate micronutrient levels. A comprehensive analysis of laboratory and hematopathologic findings in BMS patients with unexplained cytopenia(s) has not been previously described.METHODS: We reviewed the clinical and laboratory data, bone marrow histology, and used ancillary testing to characterize patients with a history of BMS who had subsequent bone marrow biopsies due to unexplained cytopenia(s).RESULTS: All patients h...
Source: International Journal of Laboratory Hematology - October 20, 2021 Category: Hematology Authors: Frido K Bruehl David S Bosler W Scott Butsch Daniel H Farkas Sarah L Ondrejka Source Type: research

Detection of Southern Asian Ovalocytosis with Sysmex XN-10: A complement to the decision tree previously described
Int J Lab Hematol. 2021 Oct 18. doi: 10.1111/ijlh.13733. Online ahead of print.NO ABSTRACTPMID:34664395 | DOI:10.1111/ijlh.13733 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 19, 2021 Category: Hematology Authors: Vanessa Nivaggioni Edwin Van Mirre Julie Brousseau Marie Loosveld Source Type: research

Detection of Southern Asian Ovalocytosis with Sysmex XN-10: A complement to the decision tree previously described
Int J Lab Hematol. 2021 Oct 18. doi: 10.1111/ijlh.13733. Online ahead of print.NO ABSTRACTPMID:34664395 | DOI:10.1111/ijlh.13733 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 19, 2021 Category: Hematology Authors: Vanessa Nivaggioni Edwin Van Mirre Julie Brousseau Marie Loosveld Source Type: research

Incidence of SARS-COV-2 infection in sickle cell patients presenting with a painful crisis: A 12-month prospective cohort study
Int J Lab Hematol. 2021 Oct 15. doi: 10.1111/ijlh.13739. Online ahead of print.NO ABSTRACTPMID:34651455 | DOI:10.1111/ijlh.13739 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 15, 2021 Category: Hematology Authors: Kad ère Konté Erfan Nur Man Wai Tang Jarom Heijmans Charlotte F J van Tuijn Bart J Biemond Source Type: research

Incidence of SARS-COV-2 infection in sickle cell patients presenting with a painful crisis: A 12-month prospective cohort study
Int J Lab Hematol. 2021 Oct 15. doi: 10.1111/ijlh.13739. Online ahead of print.NO ABSTRACTPMID:34651455 | DOI:10.1111/ijlh.13739 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 15, 2021 Category: Hematology Authors: Kad ère Konté Erfan Nur Man Wai Tang Jarom Heijmans Charlotte F J van Tuijn Bart J Biemond Source Type: research

Incidence of SARS-COV-2 infection in sickle cell patients presenting with a painful crisis: A 12-month prospective cohort study
Int J Lab Hematol. 2021 Oct 15. doi: 10.1111/ijlh.13739. Online ahead of print.NO ABSTRACTPMID:34651455 | DOI:10.1111/ijlh.13739 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 15, 2021 Category: Hematology Authors: Kad ère Konté Erfan Nur Man Wai Tang Jarom Heijmans Charlotte F J van Tuijn Bart J Biemond Source Type: research

Incidence of SARS-COV-2 infection in sickle cell patients presenting with a painful crisis: A 12-month prospective cohort study
Int J Lab Hematol. 2021 Oct 15. doi: 10.1111/ijlh.13739. Online ahead of print.NO ABSTRACTPMID:34651455 | DOI:10.1111/ijlh.13739 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 15, 2021 Category: Hematology Authors: Kad ère Konté Erfan Nur Man Wai Tang Jarom Heijmans Charlotte F J van Tuijn Bart J Biemond Source Type: research

Lineage switch from acute myeloid leukemia with KMT2A-PTD to mixed phenotype acute leukemia with t(v;11q23)
Int J Lab Hematol. 2021 Oct 12. doi: 10.1111/ijlh.13734. Online ahead of print.NO ABSTRACTPMID:34643033 | DOI:10.1111/ijlh.13734 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 13, 2021 Category: Hematology Authors: Ting Li Man Chen Minjing Fu Aixian Wang Hui Wang Source Type: research

The modification of the thrombin generation assay for the clinical assessment of hypercoagulability in patients receiving heparin therapy
CONCLUSION: Polybrene, P2Rho, and heparinase HEP-TEM effectively neutralized heparin at prophylactic and therapeutical doses of both low molecular weight and unfractionated heparin. The advantages and limits of each molecule and the most favorable combinations of TG-trigger and antagonist are discussed.PMID:34643035 | DOI:10.1111/ijlh.13735 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 13, 2021 Category: Hematology Authors: Remi Benoit Christophe Nougier Helene Desmurs-Clavel Marie Simon Yesim Dargaud Source Type: research

Alectinib-induced red cell morphological changes in a patient with underlying α-thalassaemia trait
Int J Lab Hematol. 2021 Oct 13. doi: 10.1111/ijlh.13730. Online ahead of print.NO ABSTRACTPMID:34644447 | DOI:10.1111/ijlh.13730 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 13, 2021 Category: Hematology Authors: Ting Hon Stanford Li Yin Kwan Jeannie Chik Wai Shan Wong Source Type: research

Lineage switch from acute myeloid leukemia with KMT2A-PTD to mixed phenotype acute leukemia with t(v;11q23)
Int J Lab Hematol. 2021 Oct 12. doi: 10.1111/ijlh.13734. Online ahead of print.NO ABSTRACTPMID:34643033 | DOI:10.1111/ijlh.13734 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 13, 2021 Category: Hematology Authors: Ting Li Man Chen Minjing Fu Aixian Wang Hui Wang Source Type: research

The modification of the thrombin generation assay for the clinical assessment of hypercoagulability in patients receiving heparin therapy
CONCLUSION: Polybrene, P2Rho, and heparinase HEP-TEM effectively neutralized heparin at prophylactic and therapeutical doses of both low molecular weight and unfractionated heparin. The advantages and limits of each molecule and the most favorable combinations of TG-trigger and antagonist are discussed.PMID:34643035 | DOI:10.1111/ijlh.13735 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 13, 2021 Category: Hematology Authors: Remi Benoit Christophe Nougier Helene Desmurs-Clavel Marie Simon Yesim Dargaud Source Type: research

Alectinib-induced red cell morphological changes in a patient with underlying α-thalassaemia trait
Int J Lab Hematol. 2021 Oct 13. doi: 10.1111/ijlh.13730. Online ahead of print.NO ABSTRACTPMID:34644447 | DOI:10.1111/ijlh.13730 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 13, 2021 Category: Hematology Authors: Ting Hon Stanford Li Yin Kwan Jeannie Chik Wai Shan Wong Source Type: research

The success rate of interphase fluorescence in situ hybridization in plasma cell disorders can be improved using unconventional sources of plasma cells
Int J Lab Hematol. 2021 Oct 11. doi: 10.1111/ijlh.13731. Online ahead of print.ABSTRACTBACKGROUND: Immunomagnetic cell sorting (IMCS) is a preferred technique for the enrichment of plasma cells (PC) before fluorescence in situ hybridization (FISH). Here, we share our real-world experience regarding the success rate of IMCS, its limitations, and the utility of alternate sources to obtain a successful FISH in various PC disorders.MATERIALS AND METHODS: A retrospective analysis was performed in patients with a PC neoplasm, who underwent bone marrow (BM) examination, and FISH testing over 30 months. In all cases with an unsucc...
Source: International Journal of Laboratory Hematology - October 12, 2021 Category: Hematology Authors: Vandana Panakkal Sonia Rana Shailja Rathore Anshu Anshu Anand Balakrishnan Charanpreet Singh Aditya Jandial Man Updesh Singh Sachdeva Neelam Varma Deepesh Lad Pankaj Malhotra Sreejesh Sreedharanunni Source Type: research

Impact of centrifugation time and pneumatic tube transport on plasma concentrations of direct oral anticoagulants
Int J Lab Hematol. 2021 Oct 12. doi: 10.1111/ijlh.13729. Online ahead of print.ABSTRACTINTRODUCTION: Rapid results are needed when plasma concentrations of direct oral anticoagulants (DOACs) are required in acute clinical settings. We evaluated the impact of centrifugation time and pneumatic tube transport on DOAC plasma concentrations with the overall aim of reducing turnaround time.METHODS: Blood samples were spiked with rivaroxaban, apixaban or dabigatran in a low and a high concentration prior to centrifugation for 25 minutes (3163 g) or 5 minutes (3000 g) (n = 20 for each DOAC). Both samples spiked with DOACs (n = 20 ...
Source: International Journal of Laboratory Hematology - October 12, 2021 Category: Hematology Authors: Emma Roginski Peter H Nissen Johanne Andersen Hojbjerg Erik Lerkevang Grove Anne-Mette Hvas Source Type: research

The success rate of interphase fluorescence in situ hybridization in plasma cell disorders can be improved using unconventional sources of plasma cells
Int J Lab Hematol. 2021 Oct 11. doi: 10.1111/ijlh.13731. Online ahead of print.ABSTRACTBACKGROUND: Immunomagnetic cell sorting (IMCS) is a preferred technique for the enrichment of plasma cells (PC) before fluorescence in situ hybridization (FISH). Here, we share our real-world experience regarding the success rate of IMCS, its limitations, and the utility of alternate sources to obtain a successful FISH in various PC disorders.MATERIALS AND METHODS: A retrospective analysis was performed in patients with a PC neoplasm, who underwent bone marrow (BM) examination, and FISH testing over 30 months. In all cases with an unsucc...
Source: International Journal of Laboratory Hematology - October 12, 2021 Category: Hematology Authors: Vandana Panakkal Sonia Rana Shailja Rathore Anshu Anshu Anand Balakrishnan Charanpreet Singh Aditya Jandial Man Updesh Singh Sachdeva Neelam Varma Deepesh Lad Pankaj Malhotra Sreejesh Sreedharanunni Source Type: research

Impact of centrifugation time and pneumatic tube transport on plasma concentrations of direct oral anticoagulants
Int J Lab Hematol. 2021 Oct 12. doi: 10.1111/ijlh.13729. Online ahead of print.ABSTRACTINTRODUCTION: Rapid results are needed when plasma concentrations of direct oral anticoagulants (DOACs) are required in acute clinical settings. We evaluated the impact of centrifugation time and pneumatic tube transport on DOAC plasma concentrations with the overall aim of reducing turnaround time.METHODS: Blood samples were spiked with rivaroxaban, apixaban or dabigatran in a low and a high concentration prior to centrifugation for 25 minutes (3163 g) or 5 minutes (3000 g) (n = 20 for each DOAC). Both samples spiked with DOACs (n = 20 ...
Source: International Journal of Laboratory Hematology - October 12, 2021 Category: Hematology Authors: Emma Roginski Peter H Nissen Johanne Andersen Hojbjerg Erik Lerkevang Grove Anne-Mette Hvas Source Type: research

Reflex factor coagulation testing in patients with an unexplained prolonged aPTT: An institutional retrospective review
CONCLUSION: Reflex coagulation investigations benefited patients presenting with unexplained bleeding as this expedited the diagnosis and management of clinically significant bleeding disorders. RCI for preoperative evaluation infrequently led to additional hemostatic support/referral to hematology. The lack of additional workup for an abnormal factor activity level suggests laboratory alert fatigue as a potential contributory factor.PMID:34623751 | DOI:10.1111/ijlh.13724 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 8, 2021 Category: Hematology Authors: Eman M Mansory Fadi Bahodi Chai W Phua Source Type: research

New insights into genetic characteristics between multiple myeloma and COVID-19: An integrative bioinformatics analysis of gene expression omnibus microarray and the cancer genome atlas data
CONCLUSIONS: The NOD2 and COX6C genes might be used as prognostic biomarkers in MM. The two genes might be associated with the development of COVID-19 infection.PMID:34623759 | DOI:10.1111/ijlh.13717 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 8, 2021 Category: Hematology Authors: Fei Wang Ran Liu Jie Yang Baoan Chen Source Type: research

Diagnostic value of white blood cell parameters for COVID-19: Is there a role for HFLC and IG?
CONCLUSION: Lymphopenia is not useful in screening patients with COVID-19. HFLC is a good diagnostic marker for mild and serious disease either as a single marker or combined with WBC whereas IG is a good indicator of progression to critical disease.PMID:34623763 | DOI:10.1111/ijlh.13728 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 8, 2021 Category: Hematology Authors: Alexandra Myari Evangelia Papapetrou Christina Tsaousi Source Type: research

Reflex factor coagulation testing in patients with an unexplained prolonged aPTT: An institutional retrospective review
CONCLUSION: Reflex coagulation investigations benefited patients presenting with unexplained bleeding as this expedited the diagnosis and management of clinically significant bleeding disorders. RCI for preoperative evaluation infrequently led to additional hemostatic support/referral to hematology. The lack of additional workup for an abnormal factor activity level suggests laboratory alert fatigue as a potential contributory factor.PMID:34623751 | DOI:10.1111/ijlh.13724 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 8, 2021 Category: Hematology Authors: Eman M Mansory Fadi Bahodi Chai W Phua Source Type: research

New insights into genetic characteristics between multiple myeloma and COVID-19: An integrative bioinformatics analysis of gene expression omnibus microarray and the cancer genome atlas data
CONCLUSIONS: The NOD2 and COX6C genes might be used as prognostic biomarkers in MM. The two genes might be associated with the development of COVID-19 infection.PMID:34623759 | DOI:10.1111/ijlh.13717 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 8, 2021 Category: Hematology Authors: Fei Wang Ran Liu Jie Yang Baoan Chen Source Type: research

Diagnostic value of white blood cell parameters for COVID-19: Is there a role for HFLC and IG?
CONCLUSION: Lymphopenia is not useful in screening patients with COVID-19. HFLC is a good diagnostic marker for mild and serious disease either as a single marker or combined with WBC whereas IG is a good indicator of progression to critical disease.PMID:34623763 | DOI:10.1111/ijlh.13728 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 8, 2021 Category: Hematology Authors: Alexandra Myari Evangelia Papapetrou Christina Tsaousi Source Type: research

Reflex factor coagulation testing in patients with an unexplained prolonged aPTT: An institutional retrospective review
CONCLUSION: Reflex coagulation investigations benefited patients presenting with unexplained bleeding as this expedited the diagnosis and management of clinically significant bleeding disorders. RCI for preoperative evaluation infrequently led to additional hemostatic support/referral to hematology. The lack of additional workup for an abnormal factor activity level suggests laboratory alert fatigue as a potential contributory factor.PMID:34623751 | DOI:10.1111/ijlh.13724 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 8, 2021 Category: Hematology Authors: Eman M Mansory Fadi Bahodi Chai W Phua Source Type: research

New insights into genetic characteristics between multiple myeloma and COVID-19: An integrative bioinformatics analysis of gene expression omnibus microarray and the cancer genome atlas data
CONCLUSIONS: The NOD2 and COX6C genes might be used as prognostic biomarkers in MM. The two genes might be associated with the development of COVID-19 infection.PMID:34623759 | DOI:10.1111/ijlh.13717 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 8, 2021 Category: Hematology Authors: Fei Wang Ran Liu Jie Yang Baoan Chen Source Type: research

Diagnostic value of white blood cell parameters for COVID-19: Is there a role for HFLC and IG?
CONCLUSION: Lymphopenia is not useful in screening patients with COVID-19. HFLC is a good diagnostic marker for mild and serious disease either as a single marker or combined with WBC whereas IG is a good indicator of progression to critical disease.PMID:34623763 | DOI:10.1111/ijlh.13728 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 8, 2021 Category: Hematology Authors: Alexandra Myari Evangelia Papapetrou Christina Tsaousi Source Type: research

Reflex factor coagulation testing in patients with an unexplained prolonged aPTT: An institutional retrospective review
CONCLUSION: Reflex coagulation investigations benefited patients presenting with unexplained bleeding as this expedited the diagnosis and management of clinically significant bleeding disorders. RCI for preoperative evaluation infrequently led to additional hemostatic support/referral to hematology. The lack of additional workup for an abnormal factor activity level suggests laboratory alert fatigue as a potential contributory factor.PMID:34623751 | DOI:10.1111/ijlh.13724 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 8, 2021 Category: Hematology Authors: Eman M Mansory Fadi Bahodi Chai W Phua Source Type: research

New insights into genetic characteristics between multiple myeloma and COVID-19: An integrative bioinformatics analysis of gene expression omnibus microarray and the cancer genome atlas data
CONCLUSIONS: The NOD2 and COX6C genes might be used as prognostic biomarkers in MM. The two genes might be associated with the development of COVID-19 infection.PMID:34623759 | DOI:10.1111/ijlh.13717 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 8, 2021 Category: Hematology Authors: Fei Wang Ran Liu Jie Yang Baoan Chen Source Type: research

Diagnostic value of white blood cell parameters for COVID-19: Is there a role for HFLC and IG?
CONCLUSION: Lymphopenia is not useful in screening patients with COVID-19. HFLC is a good diagnostic marker for mild and serious disease either as a single marker or combined with WBC whereas IG is a good indicator of progression to critical disease.PMID:34623763 | DOI:10.1111/ijlh.13728 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 8, 2021 Category: Hematology Authors: Alexandra Myari Evangelia Papapetrou Christina Tsaousi Source Type: research

Leucoagglutination resolved by warming to 37 °C
Int J Lab Hematol. 2021 Oct 5. doi: 10.1111/ijlh.13726. Online ahead of print.NO ABSTRACTPMID:34611992 | DOI:10.1111/ijlh.13726 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 6, 2021 Category: Hematology Authors: Rebecca Gazelle Julia Darmanin Gaby Roche Edward Chew Source Type: research

A single-institution retrospective study of causes of prolonged prothrombin time and activated partial thromboplastin time in the outpatient setting
CONCLUSION: Prolonged PT/aPTT have a wide range of causes, including artifactual prolongation or abnormalities in secondary hemostasis due to both inherited and acquired conditions.PMID:34612006 | DOI:10.1111/ijlh.13727 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 6, 2021 Category: Hematology Authors: Antonious Z Hazim Gordon J Ruan Ryan B Khodadadi Joshua P Slusser Ariela L Marshall Rajiv K Pruthi Source Type: research

Simultaneous assessment of DOACs effect on clot formation and fibrinolysis with the FibWave
Int J Lab Hematol. 2021 Oct 5. doi: 10.1111/ijlh.13723. Online ahead of print.NO ABSTRACTPMID:34613661 | DOI:10.1111/ijlh.13723 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 6, 2021 Category: Hematology Authors: Jonathan Evrard Vincent Maloteau Jean-Michel Dogn é Jonathan Douxfils Source Type: research

Leucoagglutination resolved by warming to 37 °C
Int J Lab Hematol. 2021 Oct 5. doi: 10.1111/ijlh.13726. Online ahead of print.NO ABSTRACTPMID:34611992 | DOI:10.1111/ijlh.13726 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 6, 2021 Category: Hematology Authors: Rebecca Gazelle Julia Darmanin Gaby Roche Edward Chew Source Type: research

A single-institution retrospective study of causes of prolonged prothrombin time and activated partial thromboplastin time in the outpatient setting
CONCLUSION: Prolonged PT/aPTT have a wide range of causes, including artifactual prolongation or abnormalities in secondary hemostasis due to both inherited and acquired conditions.PMID:34612006 | DOI:10.1111/ijlh.13727 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 6, 2021 Category: Hematology Authors: Antonious Z Hazim Gordon J Ruan Ryan B Khodadadi Joshua P Slusser Ariela L Marshall Rajiv K Pruthi Source Type: research

Simultaneous assessment of DOACs effect on clot formation and fibrinolysis with the FibWave
Int J Lab Hematol. 2021 Oct 5. doi: 10.1111/ijlh.13723. Online ahead of print.NO ABSTRACTPMID:34613661 | DOI:10.1111/ijlh.13723 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 6, 2021 Category: Hematology Authors: Jonathan Evrard Vincent Maloteau Jean-Michel Dogn é Jonathan Douxfils Source Type: research

Quantification and optimization of clot retraction in washed human platelets by Sonoclot coagulation analysis
In this study, we demonstrate the novelty of this instrument in the quantitative evaluation of clot retraction in washed platelets and attempted to optimize the reference range of Sonoclot parameters including ACT - 87.3 ± 20.997, CR - 16.23 ± 3.538 and PF - 3.57 ± 0.629, (n = 10).DISCUSSION: Sonoclot analysis provides a simple and quantitative method to better understand in vitro clot retraction and its modulation by retraction components including platelet count, fibrinogen and platelet-fibrin interaction compared with existing conventional methods. Sonoclot may prove to be a valuable tool in thrombu...
Source: International Journal of Laboratory Hematology - October 5, 2021 Category: Hematology Authors: Pooja Yadav Samir K Beura Abhishek R Panigrahi Sunil K Singh Source Type: research

CBC with differential blood test as a clue to hemorrhagic fever with renal syndrome
Int J Lab Hematol. 2021 Oct 5. doi: 10.1111/ijlh.13725. Online ahead of print.NO ABSTRACTPMID:34610650 | DOI:10.1111/ijlh.13725 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 5, 2021 Category: Hematology Authors: Yiting Zhang Lixia Zhang Source Type: research

Quantification and optimization of clot retraction in washed human platelets by Sonoclot coagulation analysis
In this study, we demonstrate the novelty of this instrument in the quantitative evaluation of clot retraction in washed platelets and attempted to optimize the reference range of Sonoclot parameters including ACT - 87.3 ± 20.997, CR - 16.23 ± 3.538 and PF - 3.57 ± 0.629, (n = 10).DISCUSSION: Sonoclot analysis provides a simple and quantitative method to better understand in vitro clot retraction and its modulation by retraction components including platelet count, fibrinogen and platelet-fibrin interaction compared with existing conventional methods. Sonoclot may prove to be a valuable tool in thrombu...
Source: International Journal of Laboratory Hematology - October 5, 2021 Category: Hematology Authors: Pooja Yadav Samir K Beura Abhishek R Panigrahi Sunil K Singh Source Type: research

CBC with differential blood test as a clue to hemorrhagic fever with renal syndrome
Int J Lab Hematol. 2021 Oct 5. doi: 10.1111/ijlh.13725. Online ahead of print.NO ABSTRACTPMID:34610650 | DOI:10.1111/ijlh.13725 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - October 5, 2021 Category: Hematology Authors: Yiting Zhang Lixia Zhang Source Type: research

Changes in peripheral blood in SARS CoV-2 patients and its clinico-pathological correlation: A prospective cross-sectional study
Int J Lab Hematol. 2021 Oct 1. doi: 10.1111/ijlh.13720. Online ahead of print.ABSTRACTINTRODUCTION: Coronavirus disease 2019 (COVID-19) caused by SARS-CoV2 can present from mild flu-like symptoms to acute respiratory distress syndrome. There is multi-organ involvement; particularly, hematopoietic system can be associated with morphological changes in blood cells of COVID-19 patients.METHOD: We conducted a cross-sectional study on a cohort of 50 COVID-19 patients, confirmed on RT-PCR with documented cycle threshold (Ct) value. Peripheral blood sample of these patients was collected and examined for complete blood counts (CB...
Source: International Journal of Laboratory Hematology - October 1, 2021 Category: Hematology Authors: Shalini Bahadur Tushar Kalonia Kanchan Kamini Bhumika Gupta Shivani Kalhan Mansi Jain Source Type: research

Changes in peripheral blood in SARS CoV-2 patients and its clinico-pathological correlation: A prospective cross-sectional study
Int J Lab Hematol. 2021 Oct 1. doi: 10.1111/ijlh.13720. Online ahead of print.ABSTRACTINTRODUCTION: Coronavirus disease 2019 (COVID-19) caused by SARS-CoV2 can present from mild flu-like symptoms to acute respiratory distress syndrome. There is multi-organ involvement; particularly, hematopoietic system can be associated with morphological changes in blood cells of COVID-19 patients.METHOD: We conducted a cross-sectional study on a cohort of 50 COVID-19 patients, confirmed on RT-PCR with documented cycle threshold (Ct) value. Peripheral blood sample of these patients was collected and examined for complete blood counts (CB...
Source: International Journal of Laboratory Hematology - October 1, 2021 Category: Hematology Authors: Shalini Bahadur Tushar Kalonia Kanchan Kamini Bhumika Gupta Shivani Kalhan Mansi Jain Source Type: research

Changes in peripheral blood in SARS CoV-2 patients and its clinico-pathological correlation: A prospective cross-sectional study
Int J Lab Hematol. 2021 Oct 1. doi: 10.1111/ijlh.13720. Online ahead of print.ABSTRACTINTRODUCTION: Coronavirus disease 2019 (COVID-19) caused by SARS-CoV2 can present from mild flu-like symptoms to acute respiratory distress syndrome. There is multi-organ involvement; particularly, hematopoietic system can be associated with morphological changes in blood cells of COVID-19 patients.METHOD: We conducted a cross-sectional study on a cohort of 50 COVID-19 patients, confirmed on RT-PCR with documented cycle threshold (Ct) value. Peripheral blood sample of these patients was collected and examined for complete blood counts (CB...
Source: International Journal of Laboratory Hematology - October 1, 2021 Category: Hematology Authors: Shalini Bahadur Tushar Kalonia Kanchan Kamini Bhumika Gupta Shivani Kalhan Mansi Jain Source Type: research

Changes in peripheral blood in SARS CoV-2 patients and its clinico-pathological correlation: A prospective cross-sectional study
Int J Lab Hematol. 2021 Oct 1. doi: 10.1111/ijlh.13720. Online ahead of print.ABSTRACTINTRODUCTION: Coronavirus disease 2019 (COVID-19) caused by SARS-CoV2 can present from mild flu-like symptoms to acute respiratory distress syndrome. There is multi-organ involvement; particularly, hematopoietic system can be associated with morphological changes in blood cells of COVID-19 patients.METHOD: We conducted a cross-sectional study on a cohort of 50 COVID-19 patients, confirmed on RT-PCR with documented cycle threshold (Ct) value. Peripheral blood sample of these patients was collected and examined for complete blood counts (CB...
Source: International Journal of Laboratory Hematology - October 1, 2021 Category: Hematology Authors: Shalini Bahadur Tushar Kalonia Kanchan Kamini Bhumika Gupta Shivani Kalhan Mansi Jain Source Type: research

Molecular analysis of severe hemophilia B in Indian families: Identification of mutational hotspot and novel variants
CONCLUSIONS: This study provides a comprehensive mutational spectrum and mutation screening strategy by Sanger sequencing of F9 gene in severe hemophilia B patients, in a resource-constraint setting.PMID:34590426 | DOI:10.1111/ijlh.13715 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - September 30, 2021 Category: Hematology Authors: Neha Agrawal Ravi Kumar Suzena Masih Priyanka Srivastava Parshw Singh Sushil Kumar Jaiswal Amita Moirangthem Deepti Saxena Shubha R Phadke Kausik Mandal Source Type: research

Monocyte distribution width adds prognostic value in detection of COVID-19 respiratory failure
Int J Lab Hematol. 2021 Sep 29. doi: 10.1111/ijlh.13712. Online ahead of print.NO ABSTRACTPMID:34590430 | DOI:10.1111/ijlh.13712 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - September 30, 2021 Category: Hematology Authors: Rubayet Hossain Salman Ayub Yasir Tarabichi Source Type: research

Comparison of flow cytometry and next-generation sequencing in minimal residual disease monitoring of acute myeloid leukemia: One institute's practical clinical experience
CONCLUSION: Our findings show that flow cytometry has its advantages with comparable sensitivity in detecting minimal/measurable residual disease. Next-generation sequencing could be used in an increased and more regular capacity in conjunction with flow cytometry to achieve a more comprehensive surveillance of these patients, resulting in improved outcomes.PMID:34585519 | DOI:10.1111/ijlh.13711 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - September 29, 2021 Category: Hematology Authors: Paul F McGowan Stephen D Hyter Wei Cui Regina M Plummer Andrew K Godwin Da Zhang Source Type: research

Quantification of atypical BCR-ABL1 fusion transcripts in patients with chronic myeloid leukemia: Which approach for harmonization?
Int J Lab Hematol. 2021 Sep 29. doi: 10.1111/ijlh.13714. Online ahead of print.NO ABSTRACTPMID:34585520 | DOI:10.1111/ijlh.13714 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - September 29, 2021 Category: Hematology Authors: Úna Bhreathnach Stephen E Langabeer Source Type: research