Anti-factor Xa as the preferred assay to monitor heparin for the treatment of pulmonary embolism
CONCLUSION: We observed a low incidence of recurrent thromboembolism or PE-associated mortality utilizing an antiXa titrated UFH protocol. The use of an antiXa based heparin assay to guide heparin dosing and monitoring allows for timely and sustained therapeutic anticoagulation for treatment of PE.PMID:37989523 | DOI:10.1111/ijlh.14207 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - November 21, 2023 Category: Hematology Authors: Eric Zhu Eugene Yuriditsky Veronica Raco Alyson Katz John Papadopoulos James Horowitz Thomas Maldonado Tania Ahuja Source Type: research

Anti-factor Xa as the preferred assay to monitor heparin for the treatment of pulmonary embolism
CONCLUSION: We observed a low incidence of recurrent thromboembolism or PE-associated mortality utilizing an antiXa titrated UFH protocol. The use of an antiXa based heparin assay to guide heparin dosing and monitoring allows for timely and sustained therapeutic anticoagulation for treatment of PE.PMID:37989523 | DOI:10.1111/ijlh.14207 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - November 21, 2023 Category: Hematology Authors: Eric Zhu Eugene Yuriditsky Veronica Raco Alyson Katz John Papadopoulos James Horowitz Thomas Maldonado Tania Ahuja Source Type: research

Anti-factor Xa as the preferred assay to monitor heparin for the treatment of pulmonary embolism
CONCLUSION: We observed a low incidence of recurrent thromboembolism or PE-associated mortality utilizing an antiXa titrated UFH protocol. The use of an antiXa based heparin assay to guide heparin dosing and monitoring allows for timely and sustained therapeutic anticoagulation for treatment of PE.PMID:37989523 | DOI:10.1111/ijlh.14207 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - November 21, 2023 Category: Hematology Authors: Eric Zhu Eugene Yuriditsky Veronica Raco Alyson Katz John Papadopoulos James Horowitz Thomas Maldonado Tania Ahuja Source Type: research

Anti-factor Xa as the preferred assay to monitor heparin for the treatment of pulmonary embolism
CONCLUSION: We observed a low incidence of recurrent thromboembolism or PE-associated mortality utilizing an antiXa titrated UFH protocol. The use of an antiXa based heparin assay to guide heparin dosing and monitoring allows for timely and sustained therapeutic anticoagulation for treatment of PE.PMID:37989523 | DOI:10.1111/ijlh.14207 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - November 21, 2023 Category: Hematology Authors: Eric Zhu Eugene Yuriditsky Veronica Raco Alyson Katz John Papadopoulos James Horowitz Thomas Maldonado Tania Ahuja Source Type: research

Anti-factor Xa as the preferred assay to monitor heparin for the treatment of pulmonary embolism
CONCLUSION: We observed a low incidence of recurrent thromboembolism or PE-associated mortality utilizing an antiXa titrated UFH protocol. The use of an antiXa based heparin assay to guide heparin dosing and monitoring allows for timely and sustained therapeutic anticoagulation for treatment of PE.PMID:37989523 | DOI:10.1111/ijlh.14207 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - November 21, 2023 Category: Hematology Authors: Eric Zhu Eugene Yuriditsky Veronica Raco Alyson Katz John Papadopoulos James Horowitz Thomas Maldonado Tania Ahuja Source Type: research

Anti-factor Xa as the preferred assay to monitor heparin for the treatment of pulmonary embolism
CONCLUSION: We observed a low incidence of recurrent thromboembolism or PE-associated mortality utilizing an antiXa titrated UFH protocol. The use of an antiXa based heparin assay to guide heparin dosing and monitoring allows for timely and sustained therapeutic anticoagulation for treatment of PE.PMID:37989523 | DOI:10.1111/ijlh.14207 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - November 21, 2023 Category: Hematology Authors: Eric Zhu Eugene Yuriditsky Veronica Raco Alyson Katz John Papadopoulos James Horowitz Thomas Maldonado Tania Ahuja Source Type: research

Anti-factor Xa as the preferred assay to monitor heparin for the treatment of pulmonary embolism
CONCLUSION: We observed a low incidence of recurrent thromboembolism or PE-associated mortality utilizing an antiXa titrated UFH protocol. The use of an antiXa based heparin assay to guide heparin dosing and monitoring allows for timely and sustained therapeutic anticoagulation for treatment of PE.PMID:37989523 | DOI:10.1111/ijlh.14207 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - November 21, 2023 Category: Hematology Authors: Eric Zhu Eugene Yuriditsky Veronica Raco Alyson Katz John Papadopoulos James Horowitz Thomas Maldonado Tania Ahuja Source Type: research

Anti-factor Xa as the preferred assay to monitor heparin for the treatment of pulmonary embolism
CONCLUSION: We observed a low incidence of recurrent thromboembolism or PE-associated mortality utilizing an antiXa titrated UFH protocol. The use of an antiXa based heparin assay to guide heparin dosing and monitoring allows for timely and sustained therapeutic anticoagulation for treatment of PE.PMID:37989523 | DOI:10.1111/ijlh.14207 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - November 21, 2023 Category: Hematology Authors: Eric Zhu Eugene Yuriditsky Veronica Raco Alyson Katz John Papadopoulos James Horowitz Thomas Maldonado Tania Ahuja Source Type: research

International council for standardisation in haematology recommendations on fibrinogen assays, thrombin clotting time and related tests in the investigation of bleeding disorders
Int J Lab Hematol. 2023 Nov 20. doi: 10.1111/ijlh.14201. Online ahead of print.ABSTRACTThis guidance was prepared on behalf of the International Council for Standardisation in Haematology (ICSH) by an international working group of clinicians and scientists. The document focuses on tests and assays used for the assessment of fibrinogen function, particularly in the scenario of bleeding disorders. Thrombin clotting time (TT) is used as a screening test in some laboratories and also has some utility when direct anticoagulants are in use. The Clauss fibrinogen assay remains the method of choice for the assessment of fibrinoge...
Source: International Journal of Laboratory Hematology - November 20, 2023 Category: Hematology Authors: Ian Mackie Alessandro Casini Marlien Pieters Rajiv Pruthi Chris Reilly-Stitt Atsuo Suzuki Source Type: research

Reference intervals and biological variation in parameters of the thrombin generation test in healthy individuals
CONCLUSION: For TGT on PPP and PRP the RIs developed on our population for Peak and ETP parameters can be used. Time parameters: Lagtime and ttPeak, min with II < 0.6, require monitoring over time with RCV calculation.PMID:37985000 | DOI:10.1111/ijlh.14205 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - November 20, 2023 Category: Hematology Authors: Melnichnikova Olga Zhilenkova Yuliya Lukinov Vitaly Zolotova Ekaterina Pishchulov Konstantin Evgina Svetlana Simakova Maria Vavilova Tatyana Source Type: research

Neutrophil Reactivity Intensity and misclassification of immature granulocytes
CONCLUSION: Both NEUT-RI and the internal Sysmex flag "Abnormal WBC Scattergram" work well to identify cases of IG% misclassification. However, in our setting NEUT-RI ≥56 FI had no meaningful additional predictive capacity to identify misclassifications beyond our current smear rules.PMID:37985128 | DOI:10.1111/ijlh.14204 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - November 20, 2023 Category: Hematology Authors: Elias Frost Wiwe Isabella Katarina Kofoed Muriel Julie Falk Dufr échou Jens Peter Philipsen Birthe Lemvig Katrine Laura Rasmussen Julie Smith Thore Hillig Source Type: research

Platelet indices and angiogenesis markers in hypertensive disorders of pregnancy
CONCLUSION: Platelet indices can be potentially applied as additional tools for the diagnosis and management of HDP. Activated platelets may act as an extra source of sFlt-1 in PE.PMID:37953406 | DOI:10.1111/ijlh.14202 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - November 12, 2023 Category: Hematology Authors: Laura Mattana Dionisio Giovani Marino Favero Source Type: research

Erythrophagocytosis by dysplastic neutrophils and their precursors
Int J Lab Hematol. 2023 Nov 12. doi: 10.1111/ijlh.14203. Online ahead of print.NO ABSTRACTPMID:37953407 | DOI:10.1111/ijlh.14203 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - November 12, 2023 Category: Hematology Authors: Yue Zhao Sophie Parks Imran Siddiqi Endi Wang Source Type: research

Diagnosing familial platelet disorder with predisposition to myeloid malignancy: Lessons learned from a germline whole-gene deletion of RUNX1
Int J Lab Hematol. 2023 Nov 12. doi: 10.1111/ijlh.14199. Online ahead of print.NO ABSTRACTPMID:37953439 | DOI:10.1111/ijlh.14199 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - November 12, 2023 Category: Hematology Authors: John A Cliburn Jann C Uy Sharon Swift Jane L Liesveld M Anwar Iqbal Audrey N Jajosky Michael W Becker Source Type: research

Platelet indices and angiogenesis markers in hypertensive disorders of pregnancy
CONCLUSION: Platelet indices can be potentially applied as additional tools for the diagnosis and management of HDP. Activated platelets may act as an extra source of sFlt-1 in PE.PMID:37953406 | DOI:10.1111/ijlh.14202 (Source: International Journal of Laboratory Hematology)
Source: International Journal of Laboratory Hematology - November 12, 2023 Category: Hematology Authors: Laura Mattana Dionisio Giovani Marino Favero Source Type: research