CAVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT

CONCLUSIONS: Our study identifies unbridled turnover of the potassium channel hERG as a mechanism supporting the interindividual susceptibility underlying diLQT development and demonstrates how this phenomenon is finely tuned by CAVIN1.PMID:38682330 | DOI:10.1161/CIRCULATIONAHA.123.063917

Source: Circulation - April 29, 2024 Category: Cardiology Authors: Zeina R Al Sayed C éline Pereira R émi Le Borgne Christine Viaris de Lesegno Charl ène Jouve Esthel P énard Adeline Mallet Nihar Masurkar Gildas Loussouarn Jean-Marc Verbavatz Christophe Lamaze David-Alexandre Tr égouët Jean-S ébastien Hulot Source Type: research