More about chloroquine and hydroxychloroquine, CEBM
VERDICT: The hypothesis that the 4-aminoquinolines chloroquine and hydroxychloroquine may be beneficial in the treatment of COVID-19 is a weak one, based on poor mechanistic reasoning and inconsistent results of studies in vitro, in laboratory animals, and in humans. It is likely that even if chloroquine and hydroxychloroquine are effective in COVID-19, the beneficial effects will be small. The risks of adverse reactions to these drugs may be increased in patients who are acutely ill with severe COVID-19, in many of whom high doses are being used. Macrolide antibacterial drugs, such as azithromycin, clarithromycin, ery...
Source: Current Awareness Service for Health (CASH) - June 1, 2020 Category: Consumer Health News Source Type: news

RHB-105 Effective for Eradication of Helicobacter pylori in Adults
THURSDAY, May 7, 2020 -- A novel rifabutin-based triple therapy (RHB-105) is effective for eradication of Helicobacter pylori, with eradication rates unaffected by resistance to clarithromycin or metronidazole, according to a study published online... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - May 7, 2020 Category: Pharmaceuticals Source Type: news

Common antibiotics tied to miscarriages may also lead to birth defects
(Reuters Health) - Pregnant women have another reason to avoid taking a class of antibiotics that includes erythromycin, clarithromycin and azithromycin: it may increase their baby's risk of birth defects, a UK study suggests. (Source: Reuters: Health)
Source: Reuters: Health - March 6, 2020 Category: Consumer Health News Tags: healthNews Source Type: news

Common Antibiotics Linked To Increased Risk Of Birth Defects, Study Says
(CNN) — Taking some common antibiotics during the first trimester of pregnancy was linked with higher risk of birth defects, according to a new study. The study, published Wednesday in the medical journal BMJ, found an increased risk of birth defects in the children of women who were prescribed macrolides during the first three months of pregnancy compared to mothers who were prescribed penicillin. Macrolide antibiotics include erythromycin, clarithromycin and azithromycin, and they are used to treat infections, such as pneumonia, bronchitis and urinary, skin and sexually transmitted diseases. They are often prescrib...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - February 20, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN Source Type: news

Macrolide Antibiotics Early in Pregnancy Tied to Birth Defects
Taking antibiotics like erythromycin, clarithromycin or azithromycin early in the course of pregnancy may increase the risk of birth defects. (Source: NYT Health)
Source: NYT Health - February 20, 2020 Category: Consumer Health News Authors: Nicholas Bakalar Tags: Antibiotics Pregnancy and Childbirth Birth Defects Heart Infections Source Type: news

FDA OKs First Rifabutin-Based H Pylori Therapy Talicia FDA OKs First Rifabutin-Based H Pylori Therapy Talicia
Talicia combines omeprazole, amoxicillin, and rifabutin and is designed to address growing bacterial resistance to standard clarithromycin-based H pylori therapy.FDA Approvals (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - November 4, 2019 Category: Intensive Care Tags: Infectious Diseases News Alert Source Type: news

Cancer-causing stomach bug has become TWICE as hard to treat with antibiotics in the last 20 years
Rates of resistance of Helicobacter pylori against clarithromycin jumped from under 10 per cent in 1998 to almost 22 per cent last year, according to French scientists. (Source: the Mail online | Health)
Source: the Mail online | Health - October 21, 2019 Category: Consumer Health News Source Type: news

Featured Review: Adverse events in people taking macrolide antibiotics versus placebo for any indication
The review 'Adverse events in people taking macrolide antibiotics'   asked, “Will people taking a macrolide antibiotic experience more adverse events than those treated with placebo?”Macrolide antibiotics are one of many types of antibiotic. They are commonly used to treat both acute and chronic infections. The four most commonly used macrolides are azithromycin, clarithromycin, erythromycin, and roxithromycin. People taking macrolide antibiotics are at risk of experiencing adverse events such as nausea, diarrhoea or rashes.Lead author of the review Malene Plejdrup Hansen explains, “This review was u...
Source: Cochrane News and Events - December 17, 2018 Category: Information Technology Authors: Katie Abbotts Source Type: news

Lannett Announces Expanded Agreement With Strategic Alliance Partner, HEC Pharm Group, To Distribute Two FDA-Approved Products
Company Has Commenced Launch of Clarithromycin and Expects to Begin Marketing Entacapone In Early Calendar Year 2019 PHILADELPHIA, Nov. 6, 2018 -- (Healthcare Sales & Marketing Network) -- Lannett Company, Inc. (NYSE: LCI) today announced that it has e... Biopharmaceuticals, Licensing, Distribution Lannett Company, Sunshine Lake, HEC Pharm Group, clarithromycin, entacapone (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - November 6, 2018 Category: Pharmaceuticals Source Type: news

March 2, 2018 This Week in Cardiology March 2, 2018 This Week in Cardiology
Vegetarian vs Mediterranean diets, a clarithromycin alert, a new stent, best choice of IV fluid, and early work in prevention Type I diabetes are discussed in this week's podcast.theheart.org on Medscape (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 2, 2018 Category: Consumer Health News Tags: Cardiology Commentary Source Type: news

FDA: Clarithromycin Risky for Patients With Heart Disease
The FDA is warning clinicians about prescribing clarithromycin to patients with heart disease because of the risk for serious cardiac and other complications -- and even death -- that persists years later. (Source: AAFP News)
Source: AAFP News - March 1, 2018 Category: Primary Care Source Type: news

Una revisi ó n de la FDA descubre que datos adicionales respaldan la posibilidad de mayor riesgo a largo plazo del antibi ó tico claritromicina (Biaxin) en pacientes con cardiopat í as
(Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - February 27, 2018 Category: Drugs & Pharmacology Source Type: news

Una revisi ón de la FDA descubre que datos adicionales respaldan la posibilidad de mayor riesgo a largo plazo del antibiótico claritromicina (Biaxin) en pacientes con cardiopatías
(Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - February 27, 2018 Category: Drugs & Pharmacology Source Type: news

FDA Warns Heart Patients About Antibiotic Clarithromycin
Title: FDA Warns Heart Patients About Antibiotic ClarithromycinCategory: Health NewsCreated: 2/23/2018 12:00:00 AMLast Editorial Review: 2/26/2018 12:00:00 AM (Source: MedicineNet Heart General)
Source: MedicineNet Heart General - February 26, 2018 Category: Cardiology Source Type: news

D.C. Week: White House Takes New Poke at ACA
(MedPage Today) -- FDA warns patients of new risks of clarithromycin (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - February 24, 2018 Category: Infectious Diseases Source Type: news

Antibiotic linked to higher death rates heart disease
The FDA has issued a warning that the broad-spectrum antibiotic clarithromycin may raise the risk of death for heart disease patients and is advising sufferers to steer clear of the drug. (Source: the Mail online | Health)
Source: the Mail online | Health - February 23, 2018 Category: Consumer Health News Source Type: news

FDA Warns Heart Patients About Antibiotic Clarithromycin
FRIDAY, Feb. 23, 2018 -- The antibiotic clarithromycin (brand name: Biaxin) may increase the long-term risk of heart problems and death in patients with heart disease, according to U.S. health officials. As a result, the federal Food and Drug... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 23, 2018 Category: General Medicine Source Type: news

FDA Alert: Clarithromycin Risky in Patients With Heart Disease FDA Alert: Clarithromycin Risky in Patients With Heart Disease
The agency adds a new warning about the increased risk for death in patients with heart disease prescribed the antibiotic clarithromycin and recommends considering an alternative when possible.News Alerts (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 22, 2018 Category: Consumer Health News Tags: Cardiology News Alert Source Type: news

FDA Warns Heart Patients Away from Clarithromycin
(MedPage Today) -- Antibiotic appears to raise mortality risk in users with heart disease (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - February 22, 2018 Category: Infectious Diseases Source Type: news

FDA Drug Safety Communication: FDA review finds additional data supports the potential for increased long-term risks with antibiotic clarithromycin (Biaxin) in patients with heart disease
The U.S. Food and Drug Administration (FDA) is advising caution before prescribing the antibiotic clarithromycin (Biaxin) to patients with heart disease because of a potential increased risk of heart problems or death that can occur years later. Our recommendation is based on our review of the results of a 10-year follow-up study1 of patients with coronary heart disease from a large clinical trial2 that first observed this safety issue. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - February 22, 2018 Category: Drugs & Pharmacology Source Type: news

Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection: An Open-label Randomized, Controlled, Phase IIb/III Trial
This study has led to a Practice Changing Update on DynaMed Plus. It found that clarithromycin plus naproxen plus oseltamivir for 2 days followed by oseltamivir for 3 days may reduce mortality compared to oseltamivir alone for 5 days in hospitalized older adults with influenza A (H3N2) and pneumonia (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 29, 2017 Category: Consumer Health News Source Type: news

These 3 Superbugs Pose The Greatest Risk To Human Health
The World Health Organization is issuing a warning about a group of deadly bacteria: Recently, the WHO released its first-ever list of “priority pathogens,” a list of antibiotic-resistant bacteria that the organization says pose the greatest threat to human health. The list is divided into three categories: critical-, high- and medium-priority. Three pathogens made it into the critical-priority group. These bacteria are resistant to multiple antibiotics and pose a high risk to people in hospitals and nursing homes, the WHO says. Multidrug-resistant bacteria, sometimes called “superbugs,” are a ...
Source: Science - The Huffington Post - March 23, 2017 Category: Science Source Type: news

Prevpac (Lansoprazole, Amoxicillin and Clarithromycin) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - November 29, 2016 Category: Drugs & Pharmacology Source Type: news

clarithromycin, Biaxin
Title: clarithromycin, Biaxin Category: Medications Created: 12/31/1997 12:00:00 AM Last Editorial Review: 7/29/2016 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - July 29, 2016 Category: Drugs & Pharmacology Source Type: news

Two Weeks of PAM Triple Therapy for H pylori as Effective as PACTwo Weeks of PAM Triple Therapy for H pylori as Effective as PAC
Triple therapy combining a proton-pump inhibitor (PPI), amoxicillin, and high-dose metronidazole (PAM) given thrice daily for 14 days provides Helicobacter pylori eradication rates similar to those with triple-therapy regimens containing clarithromycin (PAC), according to a new report. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 19, 2016 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

Biaxin, Biaxin XL (Clarithromycin) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - June 28, 2016 Category: Drugs & Pharmacology Source Type: news

New Lyme Disease Study Reveals Strong Reporting Bias
This study is a useful contribution to ongoing investigations of how to treat ongoing Lyme disease symptoms among patients who have received the standard 28-day course of doxycycline and continue to experience severe symptoms commonly associated with Lyme disease. This study is also significant because, unlike the majority of Lyme disease-related studies published in peer-reviewed medical journals, it made international headlines in mainstream news outlets. Some publications that specialize in medical and health-related stories covered the story appropriately, such as Medscape, whose headline reads, "Post-Treatment Ly...
Source: Healthy Living - The Huffington Post - April 8, 2016 Category: Consumer Health News Source Type: news

Cardiovascular outcomes associated with use of clarithromycin: population based study
This research article looks at current clarithromycin use associated with increased risk of myocardial infarction, arrhythmia, and death compared to current amoxicillin use in adults. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 11, 2016 Category: Consumer Health News Source Type: news

Clarithromycin and Short-term Risk of Cardiovascular EventsClarithromycin and Short-term Risk of Cardiovascular Events
Clarithromycin is associated with an increased short-term risk of cardiovascular morbidity, especially in older patients and those with hypertension or diabetes, according to a new population-based study. Reuters Health Information (Source: Medscape Infectious Diseases Headlines)
Source: Medscape Infectious Diseases Headlines - January 22, 2016 Category: Infectious Diseases Tags: Infectious Diseases News Source Type: news

Two commonly used antibiotics OK during pregnancy
Stephen FellerMONTREAL, Oct. 30 (UPI) -- Researchers found that two of the most commonly used antibiotics -- azithromycin and clarithromycin -- are safe for women to take during pregnancy. (Source: Health News - UPI.com)
Source: Health News - UPI.com - October 30, 2015 Category: Consumer Health News Source Type: news

Your NEJM Group Today: Torture at CIA "Black Sites", Half Dose of Clarithromycin for H. pylori, New York EM Opportunities (FREE)
By the Editors NEJM Group offers so many valuable resources for practicing clinicians. Here's what we chose for you today:NEJM Clinical Practice Center: Perspective: According … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - June 15, 2015 Category: Primary Care Source Type: news

'Modest' Elevated Risk With Clarithromycin Plus Some Statins 'Modest' Elevated Risk With Clarithromycin Plus Some Statins
It was seen for the antibiotic with statins not metabolized via cytochrome P450 3A4, researchers say. Though small, the added risk may be important in practice given how often the drugs are combined. Heartwire (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - December 30, 2014 Category: Cardiology Tags: Cardiology News Source Type: news

Combining statin with antibiotic can 'increase risk of adverse events'
Combining the antibiotic clarithromycin with some statins increases the risk of adverse events, which may lead to hospital admission in older patients, according to Canadian researchers. (Source: Nursing Times Breaking News)
Source: Nursing Times Breaking News - December 23, 2014 Category: Nursing Source Type: news

Clarithromycin Plus Certain Statins Associated with Hospitalization Risk in Older Adults (FREE)
By Kelly Young Edited by David G. Fairchild, MD, MPH Clarithromycin — when coprescribed with some statins in older adults — is associated with increased risks for adverse outcomes including mortality, according to an observational study … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - December 23, 2014 Category: Primary Care Source Type: news

Clarithromycin-statin mix can cause drug interactions, requiring hospitalization
The combination of the common antibiotic clarithromycin with some statins increases the risk of adverse events, which may require hospital admission for older people, according to a new study. Statins, used to lower cholesterol, are one of the most widely prescribed drugs, with projections estimated at more than 1 billion people around the globe. Although uncommon, severe adverse events can occur in some patients when certain medications interact with the statin and affect the way it is metabolized. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - December 22, 2014 Category: Science Source Type: news

Certain Antibiotic/Statin Combos May Be Unsafe Mix
Use of clarithromycin along with the cholesterol-lowering meds had higher risk of side effects Source: HealthDay Related MedlinePlus Pages: Antibiotics, Drug Reactions, Statins (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - December 22, 2014 Category: Consumer Health News Source Type: news

Study links common antibiotic to heart deaths
New research has uncovered a correlation between the antibiotic Clarithromycin and an increase in heart deaths. Despite the connection, researchers say the risk is small, and that doctors shouldn't alter the way they administer the drug. CBS News' Michelle Sigona reports. (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - August 21, 2014 Category: Consumer Health News Source Type: news

Increased Heart Risk Linked To Popular Antibiotic
Acute use of the popular macrolide antibiotic clarithromycin has been linked to a small but significant increase in cardiac death. In a report in the BMJ, researchers in Denmark analyzed the effects over a 14-year period of the acute use of penicillin V, roxithromycin, and clarithromycin. (Source: Forbes.com Healthcare News)
Source: Forbes.com Healthcare News - August 20, 2014 Category: Pharmaceuticals Authors: Larry Husten Source Type: news

Clarithromycin May Boost Risk of Cardiac Death (CME/CE)
(MedPage Today) -- The antibiotic clarithromycin was associated with a significantly increased risk for cardiac death, a large Danish study found. (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - August 20, 2014 Category: Primary Care Source Type: news

Common antibiotic linked to 'tiny' rise in heart deaths
Conclusion The conclusion that the risk of cardiac death during the use of clarithromycin is 76% higher than that for penicillin V was based on a small number of cardiac deaths. In fact, it occurred during 0.01% of prescriptions of clarithromycin, compared with 0.005% during prescriptions for penicillin V. A death rate just a bit higher than a very small death rate is still very small. This means that from an individual point of view, the risk of cardiac death from taking either antibiotic is minimal. This study does not prove clarithromycin caused any cardiac deaths. It only showed a very small increa...
Source: NHS News Feed - August 20, 2014 Category: Consumer Health News Tags: Medication Medical practice Source Type: news

Antibiotic Might Raise Heart Risks for Some
People with underlying heart rhythm disorders may want to avoid clarithromycin, study suggests Source: HealthDay Related MedlinePlus Pages: Antibiotics, Arrhythmia (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - August 20, 2014 Category: Consumer Health News Source Type: news

Antibiotic Clarithromycin 'linked to heart deaths'
A British study found clarithromycin, which is widely used for treating common bacterial infections, is linked with a 76 per cent higher risk of heart deaths. (Source: the Mail online | Health)
Source: the Mail online | Health - August 20, 2014 Category: Consumer Health News Source Type: news

Antibiotic Might Raise Heart Risks for Some
People with underlying heart rhythm disorders may want to avoid clarithromycin, study suggests (Source: WebMD Health)
Source: WebMD Health - August 20, 2014 Category: Consumer Health News Source Type: news

Increased Cardiac Risk Linked to Clarithromycin (FREE)
By Larry Husten Edited by Lorenzo Di Francesco, MD, FACP, FHM Acute use of the popular macrolide antibiotic clarithromycin has been linked to a small but significant increase in cardiac death, according to a BMJ study. Using Danish registries, researchers analyzed the effects … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - August 20, 2014 Category: Primary Care Source Type: news

Antibiotic link to higher risk of cardiac death
76% higher risk of cardiac death from clarithromycin than penicillin VRelated items from OnMedicaEarly antibiotic exposure linked to obesity Macrolide antibiotics improve symptoms in bronchiectasisProbiotics don’t seem to stave off diarrhoea linked to antibiotics in elderly Cardiovascular safety of antidiabetes drugs in doubtPainkiller raises risk of irregular heartbeat in older people (Source: OnMedica Latest News)
Source: OnMedica Latest News - August 20, 2014 Category: UK Health Source Type: news

Antibiotics and risk of cardiac death
Commenting on the study published in today’s BMJ, Use of clarithromycin and roxithromycin and risk of cardiac death: cohort study, Dr Kieran Hand (PhD), Consultant Pharmacist Anti-Infectives, University Hospital Sou (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - August 20, 2014 Category: Drugs & Pharmacology Source Type: news

Clarithromycin Tied to Risk of Cardiac Death in Cohort StudyClarithromycin Tied to Risk of Cardiac Death in Cohort Study
Current use of clarithromycin, but not roxithromycin, was tied to a small absolute increased risk of cardiac death, compared with taking penicillin V, in a new study. Heartwire (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 20, 2014 Category: Consumer Health News Tags: Cardiology News Source Type: news

Steep rise in antibiotic use for coughs and colds
ConclusionThis cross-sectional study has found the proportion of people with coughs and colds that are prescribed antibiotics rose from 36% in 1999 to 51% in 2011 – an increase of approximately 40%. This is despite the publication of guidance recommending that GPs do not prescribe antibiotics for coughs and colds. It also found substantial variation between different GP practices, with 10% of practices prescribing antibiotics for less than 32% of cases and 10% of practices prescribing antibiotics for more than 65% of cases, suggesting that substantially lower rates of prescribing could be achieved.The ...
Source: NHS News Feed - August 5, 2014 Category: Consumer Health News Tags: Medical practice Medication Source Type: news

UK says Mylan recalls batches of Polish-made antibiotic
LONDON (Reuters) - U.S. drugmaker Mylan is recalling batches of the injectable antibiotic clarithromycin made in Poland due to possible impurities, Britain's healthcare regulator said on Wednesday. (Source: Reuters: Health)
Source: Reuters: Health - June 19, 2014 Category: Consumer Health News Tags: healthNews Source Type: news

UK says Mylan recalls batches of Indian-made antibiotic
LONDON (Reuters) - U.S. drugmaker Mylan is recalling batches of the injectable antibiotic clarithromycin made in India due to possible impurities, Britain's healthcare regulator said on Wednesday. (Source: Reuters: Health)
Source: Reuters: Health - June 18, 2014 Category: Consumer Health News Tags: healthNews Source Type: news