Transcriptome and proteome analyses reveal that upregulation of GSTM2 by allisartan improves cardiac remodeling and dysfunction in hypertensive rats
In conclusion, the present study demonstrated that allisartan can effectively control blood pressure in SHRs, and improves cardiac remodeling and cardiac dysfunction. Allisartan may also upregulate the expression levels of GSTM2 in the hearts of SHRs and significantly affect glutathione metabolism, as determined by transcriptome and proteome analyses. The cardioprotective effect of allisartan may be mediated through activation of the PI3K-AKT-Nrf2 signaling pathway, upregulation of GSTM2 expression and reduction of cardiomyocyte apoptosis in SHRs.PMID:38590561 | PMC:PMC11000455 | DOI:10.3892/etm.2024.12508 (Source: Experim...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Hao Wu Yajun Zhai Jing Yu Liping Wei Xin Qi Source Type: research
The twin-arginine translocation (Tat) system
Curr Biol. 2024 Apr 8;34(7):R267-R268. doi: 10.1016/j.cub.2024.02.039.ABSTRACTIn this Quick guide, Palmer and Berks introduce the twin-arginine translocation (Tat) systems. Tats are found in a variety of microbes and microbe-derived organelles, and are known to translocate folded substrate proteins across biological membranes.PMID:38593766 | DOI:10.1016/j.cub.2024.02.039 (Source: Current Biology)
Source: Current Biology - April 9, 2024 Category: Biology Authors: Tracy Palmer Ben C Berks Source Type: research
BMP7-induced osteoblast differentiation requires hedgehog signaling and involves nuclear mechanisms of gene expression control
In conclusion, this study highlights the positive impact of epigenetic control on the expression of genes related to hedgehog signaling during the morphogenetic changes induced by BMP7 signaling in osteoblasts.PMID:38591759 | DOI:10.1002/cbin.12161 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Georgia da Silva Feltran Amanda Fantini de Andrade C élio Jr da C Fernandes Rodrigo A Foganholi da Silva Willian F Zambuzzi Source Type: research
Matrix mechanics regulates muscle regeneration by modulating kinesin-1 activity
Biomaterials. 2024 Mar 29;308:122551. doi: 10.1016/j.biomaterials.2024.122551. Online ahead of print.ABSTRACTSarcopenia, a prevalent muscle disease characterized by muscle mass and strength reduction, is associated with impaired skeletal muscle regeneration. However, the influence of the biomechanical properties of sarcopenic skeletal muscle on the efficiency of the myogenic program remains unclear. Herein, we established a mouse model of sarcopenia and observed a reduction in stiffness within the sarcopenic skeletal muscle in vivo. To investigate whether the biomechanical properties of skeletal muscle directly impact the ...
Source: Biomaterials - April 9, 2024 Category: Materials Science Authors: Wan-Yu Chiang Helen Wenshin Yu Ming-Chung Wu Yi-Man Huang Yin-Quan Chen Jong-Wei Lin Yen-Wenn Liu Li-Ru You Arthur Chiou Jean-Cheng Kuo Source Type: research
U2AF2-SNORA68 promotes triple-negative breast cancer stemness through the translocation of RPL23 from nucleoplasm to nucleolus and c-Myc expression
CONCLUSION: U2AF2-SNORA68 promotes TNBC stemness by retaining RPL23 in the nucleolus and increasing c-Myc expression, which provides new insight into the regulatory mechanism of stemness.PMID:38594783 | DOI:10.1186/s13058-024-01817-6 (Source: Cell Research)
Source: Cell Research - April 9, 2024 Category: Cytology Authors: Wenrong Zhang Xinyue Song Zining Jin Yiqi Zhang Shan Li Feng Jin Ang Zheng Source Type: research
Total ginsenosides decrease A β production through activating PPARγ
CONCLUSIONS: TG treatment reduced the production of Aβ both in vivo and in vitro. Activating PPARγ might be a potential therapeutic target of TG in facilitating Aβ clearance and ameliorating cognitive deficiency in APP/PS1 mice.PMID:38593704 | DOI:10.1016/j.biopha.2024.116577 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 9, 2024 Category: Drugs & Pharmacology Authors: Shan He Junhe Shi Lina Ma Hui Pei Ping Zhang Dazhuo Shi Hao Li Source Type: research
The twin-arginine translocation (Tat) system
Curr Biol. 2024 Apr 8;34(7):R267-R268. doi: 10.1016/j.cub.2024.02.039.ABSTRACTIn this Quick guide, Palmer and Berks introduce the twin-arginine translocation (Tat) systems. Tats are found in a variety of microbes and microbe-derived organelles, and are known to translocate folded substrate proteins across biological membranes.PMID:38593766 | DOI:10.1016/j.cub.2024.02.039 (Source: Current Biology)
Source: Current Biology - April 9, 2024 Category: Biology Authors: Tracy Palmer Ben C Berks Source Type: research
BMP7-induced osteoblast differentiation requires hedgehog signaling and involves nuclear mechanisms of gene expression control
In conclusion, this study highlights the positive impact of epigenetic control on the expression of genes related to hedgehog signaling during the morphogenetic changes induced by BMP7 signaling in osteoblasts.PMID:38591759 | DOI:10.1002/cbin.12161 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Georgia da Silva Feltran Amanda Fantini de Andrade C élio Jr da C Fernandes Rodrigo A Foganholi da Silva Willian F Zambuzzi Source Type: research
Matrix mechanics regulates muscle regeneration by modulating kinesin-1 activity
Biomaterials. 2024 Mar 29;308:122551. doi: 10.1016/j.biomaterials.2024.122551. Online ahead of print.ABSTRACTSarcopenia, a prevalent muscle disease characterized by muscle mass and strength reduction, is associated with impaired skeletal muscle regeneration. However, the influence of the biomechanical properties of sarcopenic skeletal muscle on the efficiency of the myogenic program remains unclear. Herein, we established a mouse model of sarcopenia and observed a reduction in stiffness within the sarcopenic skeletal muscle in vivo. To investigate whether the biomechanical properties of skeletal muscle directly impact the ...
Source: Biomaterials - April 9, 2024 Category: Materials Science Authors: Wan-Yu Chiang Helen Wenshin Yu Ming-Chung Wu Yi-Man Huang Yin-Quan Chen Jong-Wei Lin Yen-Wenn Liu Li-Ru You Arthur Chiou Jean-Cheng Kuo Source Type: research
BMP7-induced osteoblast differentiation requires hedgehog signaling and involves nuclear mechanisms of gene expression control
In conclusion, this study highlights the positive impact of epigenetic control on the expression of genes related to hedgehog signaling during the morphogenetic changes induced by BMP7 signaling in osteoblasts.PMID:38591759 | DOI:10.1002/cbin.12161 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Georgia da Silva Feltran Amanda Fantini de Andrade C élio Jr da C Fernandes Rodrigo A Foganholi da Silva Willian F Zambuzzi Source Type: research
BMP7-induced osteoblast differentiation requires hedgehog signaling and involves nuclear mechanisms of gene expression control
In conclusion, this study highlights the positive impact of epigenetic control on the expression of genes related to hedgehog signaling during the morphogenetic changes induced by BMP7 signaling in osteoblasts.PMID:38591759 | DOI:10.1002/cbin.12161 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Georgia da Silva Feltran Amanda Fantini de Andrade C élio Jr da C Fernandes Rodrigo A Foganholi da Silva Willian F Zambuzzi Source Type: research
BMP7-induced osteoblast differentiation requires hedgehog signaling and involves nuclear mechanisms of gene expression control
In conclusion, this study highlights the positive impact of epigenetic control on the expression of genes related to hedgehog signaling during the morphogenetic changes induced by BMP7 signaling in osteoblasts.PMID:38591759 | DOI:10.1002/cbin.12161 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Georgia da Silva Feltran Amanda Fantini de Andrade C élio Jr da C Fernandes Rodrigo A Foganholi da Silva Willian F Zambuzzi Source Type: research
BMP7-induced osteoblast differentiation requires hedgehog signaling and involves nuclear mechanisms of gene expression control
In conclusion, this study highlights the positive impact of epigenetic control on the expression of genes related to hedgehog signaling during the morphogenetic changes induced by BMP7 signaling in osteoblasts.PMID:38591759 | DOI:10.1002/cbin.12161 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Georgia da Silva Feltran Amanda Fantini de Andrade C élio Jr da C Fernandes Rodrigo A Foganholi da Silva Willian F Zambuzzi Source Type: research
BMP7-induced osteoblast differentiation requires hedgehog signaling and involves nuclear mechanisms of gene expression control
In conclusion, this study highlights the positive impact of epigenetic control on the expression of genes related to hedgehog signaling during the morphogenetic changes induced by BMP7 signaling in osteoblasts.PMID:38591759 | DOI:10.1002/cbin.12161 (Source: Cell Biology International)
Source: Cell Biology International - April 9, 2024 Category: Cytology Authors: Georgia da Silva Feltran Amanda Fantini de Andrade C élio Jr da C Fernandes Rodrigo A Foganholi da Silva Willian F Zambuzzi Source Type: research
A novel mutation in the NR3C1 gene associated with reversible glucocorticoid resistance
CONCLUSION: This is the first description of a reversible glucocorticoid resistance syndrome with effective negative feedback on corticotroph cells regarding increased plasma cortisol concentrations due to the development of mild autonomous cortisol secretion.PMID:38584335 | DOI:10.1093/ejendo/lvae031 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 8, 2024 Category: Endocrinology Authors: Margaux Laulh é Emmanuelle Kuhn J érôme Bouligand Larbi Amazit Julie Perrot Elise Lebigot Peter Kamenick ỷ Marc Lomb ès J érôme Fagart Say Viengchareun Laetitia Martinerie Source Type: research
