OLFACTORY tract/BULB metal CONCENTRATION in Manganese-EXPOSED mineWORKErs
CONCLUSIONS: Our findings suggest that Mn-exposed mineworkers might have higher olfactory tract/bulb tissue Mn concentrations than non-Mn exposed mineworkers, and that concentrations might depend more on cumulative dose than recency of exposure.PMID:38582332 | DOI:10.1016/j.neuro.2024.04.001 (Source: Neurotoxicology)
Source: Neurotoxicology - April 6, 2024 Category: Neurology Authors: Luis F Gonzalez-Cuyar Gill Nelson Susan Searles Nielsen Wendy W Dlamini Amelia Keyser-Gibson C Dirk Keene Michael Paulsen Susan R Criswell Natalie Senini Lianne Sheppard Shar Samy Christopher D Simpson Marissa G Baker Brad A Racette Source Type: research
Commercial compost amendments inhibit the bioavailability and plant uptake of per- and polyfluoroalkyl substances in soil-porewater-lettuce systems
This study examined how compost affects the bioavailability and uptake of eight PFAS (two ethers, three fluorotelomer sulfonates, and three perfluorosulfonates) by lettuce (Lactuca sativa) grown in commercial organic compost-amended, PFAS spiked soils. After 50 days of greenhouse experiment, PFAS uptake by lettuce decreased (by up to 90.5 %) with the increasing compost amendment ratios (0-20 %, w/w), consistent with their decreased porewater concentrations (by 30.7-86.3 %) in compost-amended soils. Decreased bioavailability of PFAS was evidenced by the increased in-situ soil-porewater distribution coefficients (Kd) (by fac...
Source: Environment International - April 6, 2024 Category: Environmental Health Authors: Yuanbo Li Yue Zhi Rebecca Weed Stephen W Broome Detlef R U Knappe Owen W Duckworth Source Type: research
OLFACTORY tract/BULB metal CONCENTRATION in Manganese-EXPOSED mineWORKErs
CONCLUSIONS: Our findings suggest that Mn-exposed mineworkers might have higher olfactory tract/bulb tissue Mn concentrations than non-Mn exposed mineworkers, and that concentrations might depend more on cumulative dose than recency of exposure.PMID:38582332 | DOI:10.1016/j.neuro.2024.04.001 (Source: Neurotoxicology)
Source: Neurotoxicology - April 6, 2024 Category: Neurology Authors: Luis F Gonzalez-Cuyar Gill Nelson Susan Searles Nielsen Wendy W Dlamini Amelia Keyser-Gibson C Dirk Keene Michael Paulsen Susan R Criswell Natalie Senini Lianne Sheppard Shar Samy Christopher D Simpson Marissa G Baker Brad A Racette Source Type: research
OLFACTORY tract/BULB metal CONCENTRATION in Manganese-EXPOSED mineWORKErs
CONCLUSIONS: Our findings suggest that Mn-exposed mineworkers might have higher olfactory tract/bulb tissue Mn concentrations than non-Mn exposed mineworkers, and that concentrations might depend more on cumulative dose than recency of exposure.PMID:38582332 | DOI:10.1016/j.neuro.2024.04.001 (Source: Neurotoxicology)
Source: Neurotoxicology - April 6, 2024 Category: Neurology Authors: Luis F Gonzalez-Cuyar Gill Nelson Susan Searles Nielsen Wendy W Dlamini Amelia Keyser-Gibson C Dirk Keene Michael Paulsen Susan R Criswell Natalie Senini Lianne Sheppard Shar Samy Christopher D Simpson Marissa G Baker Brad A Racette Source Type: research
Altered TFEB subcellular localization in nigral neurons of subjects with incidental, sporadic and GBA-related Lewy body diseases
AbstractTranscription factor EB (TFEB) is a master regulator of genes involved in the maintenance of autophagic and lysosomal homeostasis, processes which have been implicated in the pathogenesis ofGBA-related and sporadic Parkinson ’s disease (PD), and dementia with Lewy bodies (DLB). TFEB activation results in its translocation from the cytosol to the nucleus. Here, we investigated TFEB subcellular localization and its relation to intracellular alpha-synuclein (aSyn) accumulation inpost-mortem human brain of individuals with either incidental Lewy body disease (iLBD),GBA-related PD/DLB (GBA-PD/DLB) or sporadic PD/DLB...
Source: Acta Neuropathologica - April 6, 2024 Category: Neurology Source Type: research
Insights into growth stages and genotypes in airborne Pb accumulation in Oryza sativa L. grains: Utilizing isotope fingerprinting alongside a model study
In this study, source contributions of soil, early atmospheric exposure, and late atmospheric exposure, along with their bioaccumulation ratios were examined both in the pot and field experiments using stable Pb isotope fingerprinting technology combined with a three-compartment accumulation model. Furthermore, genotype differences in airborne Pb accumulation among four field-grown rice cultivars were investigated using the partial least squares path model (PLS-PM) linking rice Pb accumulation to agronomic traits. The findings revealed that during the late growth period, the air-foliar-grain transfer of Pb was crucial for ...
Source: Chemosphere - April 5, 2024 Category: Chemistry Authors: Qi Lin Ming-Jin Zhuang Wei Dai Jing Fang Bao-Feng Zhang Jing-Dong Mao Li-Ping Lou Source Type: research
Light Induced Proton Coupled Charge Transfer Triggers Counterion Directional Translocation
Angew Chem Int Ed Engl. 2024 Apr 5:e202403317. doi: 10.1002/anie.202403317. Online ahead of print.ABSTRACTWe demonstrate directed translocation of ClO4- anions from cationic to neutral binding site along the synthetized BPym-OH dye molecule that exhibits coupled excited-state intramolecular proton-transfer (ESIPT) and charge-transfer (CT) reaction (PCCT). The results of steady-state and time-resolved spectroscopy together with computer simulation and modeling show that in low polar toluene the excited-state redistribution of electronic charge enhanced by ESIPT generates the driving force, which is much stronger than by CT ...
Source: Angewandte Chemie - April 5, 2024 Category: Chemistry Authors: Kai-Hsin Chang Yu-Hsuan Yang Kuan-Hsuan Su Yi Chen Ta-Chun Lin Jian-Liang Li Zong-Ying Liu Jing-Han Shi Tzu-Fang Wang Yi-Tyng Chang Alexander P Demchenko Hsiao-Ching Yang Pi-Tai Chou Source Type: research
Insights into growth stages and genotypes in airborne Pb accumulation in Oryza sativa L. grains: Utilizing isotope fingerprinting alongside a model study
In this study, source contributions of soil, early atmospheric exposure, and late atmospheric exposure, along with their bioaccumulation ratios were examined both in the pot and field experiments using stable Pb isotope fingerprinting technology combined with a three-compartment accumulation model. Furthermore, genotype differences in airborne Pb accumulation among four field-grown rice cultivars were investigated using the partial least squares path model (PLS-PM) linking rice Pb accumulation to agronomic traits. The findings revealed that during the late growth period, the air-foliar-grain transfer of Pb was crucial for ...
Source: Chemosphere - April 5, 2024 Category: Chemistry Authors: Qi Lin Ming-Jin Zhuang Wei Dai Jing Fang Bao-Feng Zhang Jing-Dong Mao Li-Ping Lou Source Type: research
Indomethacin restrains cytoplasmic nucleic acid-stimulated immune responses by inhibiting the nuclear translocation of IRF3
J Mol Cell Biol. 2024 Apr 5:mjae015. doi: 10.1093/jmcb/mjae015. Online ahead of print.ABSTRACTThe recognition of cytosolic nucleic acid triggers the DNA/RNA sensor-IRF3 axis-mediated production of type I interferons (IFNs), which are essential for antiviral immune responses. However, the inappropriate activation of these signaling pathways is implicated in autoimmune conditions. Here, we report that indomethacin, a widely used nonsteroidal anti-inflammatory drug, inhibits nucleic acid-triggered IFN production. We found that both DNA- and RNA-stimulated IFN expression can be effectively blocked by indomethacin. Interestingl...
Source: Mol Biol Cell - April 5, 2024 Category: Molecular Biology Authors: Miao Wang Xiao-Wei Li Sen-Chao Yuan Jie Pan Zeng-Lin Guo Li-Ming Sun Shao-Zhen Jiang Ming Zhao Wen Xue Hong Cai Lin Gu Dan Luo Ling Chen Xue-Qing Zhou Qiu-Ying Han Jin Li Tao Zhou Tian Xia Tao Li Source Type: research
Autophagic-lysosomal damage induced by swainsonine is protected by trehalose through activation of TFEB-regulated pathway in renal tubular epithelial cells
In this study, we investigate the mechanism of protective effects of trehalose using renal tubular epithelial cells. The results showed that SW induced an increase in the expression level of microtubule-associated protein light chain 3-II and p62 proteins and a decrease in the expression level of ATPase H+ transporting V1 Subunit A, Cathepsin B, Cathepsin D, lysosome-associated membrane protein 2 and TFEB proteins in renal tubular epithelial cells in a time and dose-dependent manner suggesting TFEB-regulated lysosomal pathway is adversely affected by SW. Conversely, treatment with trehalose, a known activator of TFEB promo...
Source: Chemico-Biological Interactions - April 5, 2024 Category: Molecular Biology Authors: Shuhang Zhang Hai Yin Yiqingqing Zhang Yanli Zhu Xueyao Zhu Wenting Zhu Lihui Tang Yiling Liu Kexin Wu Baoyu Zhao Yanan Tian Hao Lu Source Type: research
Kidney-tonifying blood-activating decoction delays ventricular remodeling in rats with chronic heart failure by regulating gut microbiota and metabolites and p38 mitogen-activated protein kinase/p65 nuclear factor kappa-B/aquaporin-4 signaling pathway
CONCLUSIONS: KTBA decoction manipulates the expression of several key proteins in the p38MAPK/p65NF-κB/AQP4 signaling pathway, modulates gut microbiota and metabolites toward a more favorable profile, improves gut barrier function, delays cardiomyocyte hypertrophy and fibrosis,and improves cardiac function.PMID:38580189 | DOI:10.1016/j.jep.2024.118110 (Source: Cancer Control)
Source: Cancer Control - April 5, 2024 Category: Cancer & Oncology Authors: Rui Xu Yanping Bi Xiaoteng He Yan Zhang Xin Zhao Source Type: research
Targeted mutagenesis of negatively charged amino acids outlining the substrate translocation path within the human organic cation transporter 3
Biochem Pharmacol. 2024 Apr 3:116188. doi: 10.1016/j.bcp.2024.116188. Online ahead of print.ABSTRACTRecently published cryo-EM structures of human organic cation transporters of the SLC22 family revealed seven, sequentially arranged glutamic and aspartic acid residues, which may be relevant for interactions with positively charged substrates. We analyzed the functional consequences of removing those negative charges by creating D155N, E232Q, D382N, E390Q, E451Q, E459Q, and D478N mutants of OCT3. E232Q, E459Q, and D478N resulted in a lack of localization in the outer cell membrane and no relevant uptake activity. However, D...
Source: Biochemical Pharmacology - April 5, 2024 Category: Drugs & Pharmacology Authors: Kyra-Elisa Maria Redeker Sophie Schr öder Christof D ücker J ürgen Brockmöller Lukas Gebauer Source Type: research
Insights into growth stages and genotypes in airborne Pb accumulation in Oryza sativa L. grains: Utilizing isotope fingerprinting alongside a model study
In this study, source contributions of soil, early atmospheric exposure, and late atmospheric exposure, along with their bioaccumulation ratios were examined both in the pot and field experiments using stable Pb isotope fingerprinting technology combined with a three-compartment accumulation model. Furthermore, genotype differences in airborne Pb accumulation among four field-grown rice cultivars were investigated using the partial least squares path model (PLS-PM) linking rice Pb accumulation to agronomic traits. The findings revealed that during the late growth period, the air-foliar-grain transfer of Pb was crucial for ...
Source: Chemosphere - April 5, 2024 Category: Chemistry Authors: Qi Lin Ming-Jin Zhuang Wei Dai Jing Fang Bao-Feng Zhang Jing-Dong Mao Li-Ping Lou Source Type: research
Light Induced Proton Coupled Charge Transfer Triggers Counterion Directional Translocation
Angew Chem Int Ed Engl. 2024 Apr 5:e202403317. doi: 10.1002/anie.202403317. Online ahead of print.ABSTRACTWe demonstrate directed translocation of ClO4- anions from cationic to neutral binding site along the synthetized BPym-OH dye molecule that exhibits coupled excited-state intramolecular proton-transfer (ESIPT) and charge-transfer (CT) reaction (PCCT). The results of steady-state and time-resolved spectroscopy together with computer simulation and modeling show that in low polar toluene the excited-state redistribution of electronic charge enhanced by ESIPT generates the driving force, which is much stronger than by CT ...
Source: Angewandte Chemie - April 5, 2024 Category: Chemistry Authors: Kai-Hsin Chang Yu-Hsuan Yang Kuan-Hsuan Su Yi Chen Ta-Chun Lin Jian-Liang Li Zong-Ying Liu Jing-Han Shi Tzu-Fang Wang Yi-Tyng Chang Alexander P Demchenko Hsiao-Ching Yang Pi-Tai Chou Source Type: research
Insights into growth stages and genotypes in airborne Pb accumulation in Oryza sativa L. grains: Utilizing isotope fingerprinting alongside a model study
In this study, source contributions of soil, early atmospheric exposure, and late atmospheric exposure, along with their bioaccumulation ratios were examined both in the pot and field experiments using stable Pb isotope fingerprinting technology combined with a three-compartment accumulation model. Furthermore, genotype differences in airborne Pb accumulation among four field-grown rice cultivars were investigated using the partial least squares path model (PLS-PM) linking rice Pb accumulation to agronomic traits. The findings revealed that during the late growth period, the air-foliar-grain transfer of Pb was crucial for ...
Source: Chemosphere - April 5, 2024 Category: Chemistry Authors: Qi Lin Ming-Jin Zhuang Wei Dai Jing Fang Bao-Feng Zhang Jing-Dong Mao Li-Ping Lou Source Type: research
