Activation of angiogenin expression in macrophages by lipopolysaccharide via the TLR4/NF- κB pathway in colitis
Acta Biochim Biophys Sin (Shanghai). 2024 Apr 3. doi: 10.3724/abbs.2024013. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD) is a debilitating condition that can lead to life-threatening complications. Macrophages are crucial in IBD management because they secrete various cytokines and regulate tissue repair. Macrophage-derived angiogenin (ANG) has been shown to be essential for limiting colonic inflammation, but its upstream regulatory pathway and role in macrophages remain unclear. Here we show that ANG expression is up-regulated in macrophages during colitis treatment or upon lipopolysaccharides (LPS) trea...
Source: Acta Biochimica et Biophysica Sinica - April 3, 2024 Category: Biochemistry Authors: Zhengrong Yao Rongpan Bai Wei Liu Yaxing Liu Wei Zhou Zhengping Xu Jinghao Sheng Source Type: research
Dysregulated NUB1 and neddylation enhances rheumatoid arthritis fibroblast ‐like synoviocyte inflammatory responses
ConclusionCUL1 neddylation andNUB1 induction is dysregulated in RA, which increases FLS activation. Inhibition of neddylation is an effective therapy in an animal model of arthritis. These data suggest that neddylation system contributes to the pathogenesis of RA and that regulation of neddylation could be a novel therapeutic approach. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - April 3, 2024 Category: Rheumatology Authors: Sho Sendo,
Camilla R. L. Machado,
David L Boyle,
Robert J. Benschop,
Narayanan B. Perumal,
Eunice Choi,
Wei Wang,
Gary S Firestein Tags: Full Length Source Type: research
GSE253091 The Small Extracellular Vesicle-Mediated Intercellular Transformation of CXCR1Low to CXCR1High Tumor Cells Promotes the Progression of Head and Neck Squamous Cell Carcinoma
Contributors : Qiaoshi Xu ; Zhien Feng ; Zhengxue HanSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe heterogeneity of tumor cells enables cancers to dynamically adapt to microenvironmental stresses during progression. However, the mechanism underlying the transformation and intercellular communication between heterogeneous tumor cells has remained elusive. Here, we report a “contagion model” that mediates intercellular transformation between heterogeneous tumor cells which facilitates tumor progression. Initially identifying heterogeneous expression of CXCR1, a receptor for...
Source: GEO: Gene Expression Omnibus - April 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Molecules, Vol. 29, Pages 1605: The Lipophilic Extract from Ginkgo biloba L. Leaves Promotes Glucose Uptake and Alleviates Palmitate-Induced Insulin Resistance in C2C12 Myotubes
In conclusion, GL enhances basal glucose uptake in C2C12 myotubes and improves insulin sensitivity in palmitate-induced insulin resistant myotubes through the AMPK pathway. (Source: Molecules)
Source: Molecules - April 3, 2024 Category: Chemistry Authors: Tiantian Li Quanhe Lv Chunhui Liu Chunfei Li Xiaomin Xie Wen Zhang Tags: Article Source Type: research
The potential influence of genome-wide adaptive divergence on conservation translocation outcome in an isolated greater sage-grouse population
Conserv Biol. 2024 Apr 2:e14254. doi: 10.1111/cobi.14254. Online ahead of print.ABSTRACTConservation translocations are an important conservation tool commonly employed to augment declining or reestablish extirpated populations. One goal of augmentation is to increase genetic diversity and reduce the risk of inbreeding depression (i.e., genetic rescue). However, introducing individuals from significantly diverged populations risks disrupting coadapted traits and reducing local fitness (i.e., outbreeding depression). Genetic data are increasingly more accessible for wildlife species and can provide unique insight regarding ...
Source: Conservation Biology - April 2, 2024 Category: Biology Authors: Shawna J Zimmerman Cameron L Aldridge Michael A Schroeder Jennifer A Fike Robert Scott Cornman Sara J Oyler-McCance Source Type: research
Cordycepin alleviates hepatic fibrosis in association with the inhibition of glutaminolysis to promote hepatic stellate cell senescence
Int Immunopharmacol. 2024 Apr 1;132:111981. doi: 10.1016/j.intimp.2024.111981. Online ahead of print.ABSTRACTCordycepin (CRD) is an active component derived from Cordyceps militaris, which possesses multiple biological activities and uses in liver disease. However, whether CRD improves liver fibrosis by regulating hepatic stellate cell (HSC) activation has remained unknown. The study aims further to clarify the activities of CRD on liver fibrosis and elucidate the possible mechanism. Our results demonstrated that CRD significantly relieved hepatocyte injury and inhibited HSC activation, alleviating hepatic fibrogenesis in ...
Source: International Immunopharmacology - April 2, 2024 Category: Allergy & Immunology Authors: Zhu Liang Keyan Zhang Hongli Guo Xujiao Tang Mingzhu Chen Jinsong Shi Jing Yang Source Type: research
The potential influence of genome-wide adaptive divergence on conservation translocation outcome in an isolated greater sage-grouse population
Conserv Biol. 2024 Apr 2:e14254. doi: 10.1111/cobi.14254. Online ahead of print.ABSTRACTConservation translocations are an important conservation tool commonly employed to augment declining or reestablish extirpated populations. One goal of augmentation is to increase genetic diversity and reduce the risk of inbreeding depression (i.e., genetic rescue). However, introducing individuals from significantly diverged populations risks disrupting coadapted traits and reducing local fitness (i.e., outbreeding depression). Genetic data are increasingly more accessible for wildlife species and can provide unique insight regarding ...
Source: Conservation Biology - April 2, 2024 Category: Biology Authors: Shawna J Zimmerman Cameron L Aldridge Michael A Schroeder Jennifer A Fike Robert Scott Cornman Sara J Oyler-McCance Source Type: research
Cordycepin alleviates hepatic fibrosis in association with the inhibition of glutaminolysis to promote hepatic stellate cell senescence
Int Immunopharmacol. 2024 Apr 1;132:111981. doi: 10.1016/j.intimp.2024.111981. Online ahead of print.ABSTRACTCordycepin (CRD) is an active component derived from Cordyceps militaris, which possesses multiple biological activities and uses in liver disease. However, whether CRD improves liver fibrosis by regulating hepatic stellate cell (HSC) activation has remained unknown. The study aims further to clarify the activities of CRD on liver fibrosis and elucidate the possible mechanism. Our results demonstrated that CRD significantly relieved hepatocyte injury and inhibited HSC activation, alleviating hepatic fibrogenesis in ...
Source: International Immunopharmacology - April 2, 2024 Category: Allergy & Immunology Authors: Zhu Liang Keyan Zhang Hongli Guo Xujiao Tang Mingzhu Chen Jinsong Shi Jing Yang Source Type: research
GSE262667 SRSF7-mediated Alternative Splicing of USO1 Promotes Hepatocellular Carcinoma by Activating the MAPK/ERK1-ELK1 Pathway
Contributors : Gangqiao Zhou ; Pengbo Cao ; Qian Jin ; Hongbo Luo ; Shizhou LiSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensWe conducted a transcriptome-wide survey to identify novel hepatocellular carcinoma (HCC)-associated genes that have undergone aberrant alternative splicing. We revealed that the vesicle transport factor (USO1) is a major alternatively spliced target in HCC, mainly composed of a long wild-type isoform (USO1-L) and a short truncated isoform lacking exons 5 and 15 (USO1-S). A markedly increased isoform switching from USO1-L to USO1-S occurs in approximately ...
Source: GEO: Gene Expression Omnibus - April 2, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GLUT4 localisation with the plasma membrane is unaffected by an increase in plasma free fatty acid availability
Insulin-stimulated glucose uptake into skeletal muscle occurs via translocation of GLUT4 from intracellular storage vesicles to the plasma membrane. Elevated free fatty acid (FFA) availability via a lipid infu... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - April 2, 2024 Category: Lipidology Authors: J. S. Barrett, J. A. Strauss, L. S. Chow, S. O. Shepherd, A. J. M. Wagenmakers and Y. Wang Tags: Research Source Type: research
Comparative genomics incorporating translocation renal cell carcinoma mouse model reveals molecular mechanisms of tumorigenesis
Translocation renal cell carcinoma (tRCC) most commonly involves an ASPSCR1-TFE3 fusion, but molecular mechanisms remain elusive and animal models are lacking. Here, we show that human ASPSCR1-TFE3 driven by Pax8-Cre (a credentialed clear cell RCC driver) disrupted nephrogenesis and glomerular development, causing neonatal death, while the clear cell RCC failed driver, Sglt2-Cre, induced aggressive tRCC (as well as alveolar soft part sarcoma) with complete penetrance and short latency. However, in both contexts, ASPSCR1-TFE3 led to characteristic morphological cellular changes, loss of epithelial markers, and an epithelial...
Source: Journal of Clinical Investigation - April 1, 2024 Category: Biomedical Science Authors: Gopinath Prakasam, Akhilesh Mishra, Alana Christie, Jeffrey Miyata, Deyssy Carrillo, Vanina T. Tcheuyap, Hui Ye, Quyen N. Do, Yunguan Wang, Oscar Reig Torras, Ramesh Butti, Hua Zhong, Jeffrey Gagan, Kevin B. Jones, Thomas J. Carroll, Zora Modrusan, Steffe Source Type: research
A signaling cascade mediating fruit trait development via phosphorylation-modulated nuclear accumulation of JAZ repressor
J Integr Plant Biol. 2024 Apr 1. doi: 10.1111/jipb.13654. Online ahead of print.ABSTRACTIt is generally accepted that jasmonate-ZIM domain (JAZ) repressors act to mediate jasmonate (JA) signaling via CORONATINE-INSENSITIVE1 (COI1)-mediated degradation. Here, we report a cryptic signaling cascade where a JAZ repressor, FvJAZ12, mediates multiple signaling inputs via phosphorylation-modulated subcellular translocation rather than the COI1-mediated degradation mechanism in strawberry (Fragaria vesca). FvJAZ12 acts to regulate flavor metabolism and defense response, and was found to be the target of FvMPK6, a mitogen-activated...
Source: Journal of Integrative Plant Biology - April 1, 2024 Category: Biology Authors: Wei Wang Jinyao Ouyang Yating Li Changsheng Zhai Bing He Huahan Si Kunsong Chen Jocelyn K C Rose Wensuo Jia Source Type: research
CRISPR/Cas9n-mediated ELANE promoter editing for gene therapy of severe congenital neutropenia
Mol Ther. 2024 Mar 30:S1525-0016(24)00215-6. doi: 10.1016/j.ymthe.2024.03.037. Online ahead of print.ABSTRACTSevere congenital neutropenia (CN) is an inherited pre-leukemia bone marrow failure syndrome commonly caused by autosomal-dominant ELANE mutations (ELANE-CN). ELANE-CN patients are treated with daily injections of recombinant human granulocyte colony-stimulating factor (rhG-CSF). However, some patients do not respond to rhG-CSF, and approximately 15% of ELANE-CN patients develop myelodysplasia or acute myeloid leukemia. Here, we report the development of a curative therapy for ELANE-CN through inhibition of ELANE mR...
Source: Molecular Medicine - April 1, 2024 Category: Molecular Biology Authors: Masoud Nasri Malte Ritter Perihan Mir Benjamin Dannenmann Masako M Kaufmann Patricia Arreba-Tutusaus Yun Xu Natalia Borbaran-Bravo Maksim Klimiankou Claudia Lengerke Cornelia Zeidler Toni Cathomen Karl Welte Julia Skokowa Source Type: research
Chronic adolescent stress alters GR-FKBP5 interactions in the hippocampus of adult female rats
Stress. 2024 Jan;27(1):2312467. doi: 10.1080/10253890.2024.2312467. Epub 2024 Apr 1.ABSTRACTChronic stress exposure during development can have lasting behavioral consequences that differ in males and females. More specifically, increased depressive behaviors in females, but not males, are observed in both humans and rodent models of chronic stress. Despite these known stress-induced outcomes, the molecular consequences of chronic adolescent stress in the adult brain are less clear. The stress hormone corticosterone activates the glucocorticoid receptor, and activity of the receptor is regulated through interactions with c...
Source: Stress - April 1, 2024 Category: Research Authors: Sydney Rowson Mandakh Bekhbat Sean Kelly Molly M Hyer Samya Dyer David Weinshenker Gretchen Neigh Source Type: research
