A novel mutation in the NR3C1 gene associated with reversible glucocorticoid resistance
CONCLUSION: This is the first description of a reversible glucocorticoid resistance syndrome with effective negative feedback on corticotroph cells regarding increased plasma cortisol concentrations due to the development of mild autonomous cortisol secretion.PMID:38584335 | DOI:10.1093/ejendo/lvae031 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 8, 2024 Category: Endocrinology Authors: Margaux Laulh é Emmanuelle Kuhn J érôme Bouligand Larbi Amazit Julie Perrot Elise Lebigot Peter Kamenick ỷ Marc Lomb ès J érôme Fagart Say Viengchareun Laetitia Martinerie Source Type: research
A novel mutation in the NR3C1 gene associated with reversible glucocorticoid resistance
CONCLUSION: This is the first description of a reversible glucocorticoid resistance syndrome with effective negative feedback on corticotroph cells regarding increased plasma cortisol concentrations due to the development of mild autonomous cortisol secretion.PMID:38584335 | DOI:10.1093/ejendo/lvae031 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 8, 2024 Category: Endocrinology Authors: Margaux Laulh é Emmanuelle Kuhn J érôme Bouligand Larbi Amazit Julie Perrot Elise Lebigot Peter Kamenick ỷ Marc Lomb ès J érôme Fagart Say Viengchareun Laetitia Martinerie Source Type: research
A novel mutation in the NR3C1 gene associated with reversible glucocorticoid resistance
CONCLUSION: This is the first description of a reversible glucocorticoid resistance syndrome with effective negative feedback on corticotroph cells regarding increased plasma cortisol concentrations due to the development of mild autonomous cortisol secretion.PMID:38584335 | DOI:10.1093/ejendo/lvae031 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 8, 2024 Category: Endocrinology Authors: Margaux Laulh é Emmanuelle Kuhn J érôme Bouligand Larbi Amazit Julie Perrot Elise Lebigot Peter Kamenick ỷ Marc Lomb ès J érôme Fagart Say Viengchareun Laetitia Martinerie Source Type: research
A novel mutation in the NR3C1 gene associated with reversible glucocorticoid resistance
CONCLUSION: This is the first description of a reversible glucocorticoid resistance syndrome with effective negative feedback on corticotroph cells regarding increased plasma cortisol concentrations due to the development of mild autonomous cortisol secretion.PMID:38584335 | DOI:10.1093/ejendo/lvae031 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 8, 2024 Category: Endocrinology Authors: Margaux Laulh é Emmanuelle Kuhn J érôme Bouligand Larbi Amazit Julie Perrot Elise Lebigot Peter Kamenick ỷ Marc Lomb ès J érôme Fagart Say Viengchareun Laetitia Martinerie Source Type: research
A novel mutation in the NR3C1 gene associated with reversible glucocorticoid resistance
CONCLUSION: This is the first description of a reversible glucocorticoid resistance syndrome with effective negative feedback on corticotroph cells regarding increased plasma cortisol concentrations due to the development of mild autonomous cortisol secretion.PMID:38584335 | DOI:10.1093/ejendo/lvae031 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 8, 2024 Category: Endocrinology Authors: Margaux Laulh é Emmanuelle Kuhn J érôme Bouligand Larbi Amazit Julie Perrot Elise Lebigot Peter Kamenick ỷ Marc Lomb ès J érôme Fagart Say Viengchareun Laetitia Martinerie Source Type: research
A novel mutation in the NR3C1 gene associated with reversible glucocorticoid resistance
CONCLUSION: This is the first description of a reversible glucocorticoid resistance syndrome with effective negative feedback on corticotroph cells regarding increased plasma cortisol concentrations due to the development of mild autonomous cortisol secretion.PMID:38584335 | DOI:10.1093/ejendo/lvae031 (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - April 8, 2024 Category: Endocrinology Authors: Margaux Laulh é Emmanuelle Kuhn J érôme Bouligand Larbi Amazit Julie Perrot Elise Lebigot Peter Kamenick ỷ Marc Lomb ès J érôme Fagart Say Viengchareun Laetitia Martinerie Source Type: research
Swine acute diarrhea syndrome coronavirus Nsp1 suppresses IFN- λ1 production by degrading IRF1 via ubiquitin–proteasome pathway
In this study, we utilized IPI-FX cells (a cell line of porcine ileum epithelium) as an i n vitro model to investigate the potential immune evasion strategies employed by SADS-CoV against the IFN-λ response. Our results showed that SADS-CoV infection suppressed the production of IFN-λ1 induced by poly(I:C). Through screening SADS-CoV-encoded proteins, nsp1, nsp5, nsp10, nsp12, nsp16, E , S1, and S2 were identified as antagonists of IFN-λ1 production. Specifically, SADS-CoV nsp1 impeded the activation of the IFN-λ1 promoter mediated by MAVS, TBK1, IKKε, and IRF1. Both SADS-CoV and nsp1 obstructed poly(I:C)-induced nucl...
Source: Veterinary Research - April 8, 2024 Category: Veterinary Research Source Type: research
Quercetin and Kaempferol inhibit HMC-1 activation via SOCE/NFATc2 signaling and suppress hippocampal mast cell activation in lipopolysaccharide-induced depressive mice
ConclusionsOur results indicated that suppression of SOCE/NFATc2 pathway-mediated by ORAI channels may be the mechanism of inhibitory effect of Que and Kae on MC activation, and also suggested Que and Kae may exert the antidepressant effect through suppressing hippocampal mast cell activation. (Source: Inflammation Research)
Source: Inflammation Research - April 8, 2024 Category: Research Source Type: research
Chondroitin sulphate modified MoS < sub > 2 < /sub > nanoenzyme with multifunctional activities for treatment of Alzheimer's disease
In this study, we developed a chondroitin sulphate (CS)-modified MoS2 nanoenzyme (CS@MoS2) by harnessing the excellent biocompatibility of CS and the exceptional activities of nano-MoS2 to explore its potential in anti-AD research. Promisingly, CS@MoS2 significantly inhibited Aβ1-40 aggregation and prevented toxic injury in SH-SY5Y cells caused by Aβ1-40. In addition, CS@MoS2 protected these cells from oxidative stress damage by regulating ROS production, as well as promoting the activities of SOD and GSH-Px. CS@MoS2 also modulated the intracellular Ca2+ imbalance and downregulated Tau hyperphosphorylation by activating ...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: Jialei Tian Qian Peng Yuzhen Shen Xuan Liu Delong Li Jian Li Shuyuan Guo Caicai Meng Yuliang Xiao Source Type: research
Chondroitin sulphate modified MoS < sub > 2 < /sub > nanoenzyme with multifunctional activities for treatment of Alzheimer's disease
In this study, we developed a chondroitin sulphate (CS)-modified MoS2 nanoenzyme (CS@MoS2) by harnessing the excellent biocompatibility of CS and the exceptional activities of nano-MoS2 to explore its potential in anti-AD research. Promisingly, CS@MoS2 significantly inhibited Aβ1-40 aggregation and prevented toxic injury in SH-SY5Y cells caused by Aβ1-40. In addition, CS@MoS2 protected these cells from oxidative stress damage by regulating ROS production, as well as promoting the activities of SOD and GSH-Px. CS@MoS2 also modulated the intracellular Ca2+ imbalance and downregulated Tau hyperphosphorylation by activating ...
Source: International Journal of Biological Macromolecules - April 7, 2024 Category: Biochemistry Authors: Jialei Tian Qian Peng Yuzhen Shen Xuan Liu Delong Li Jian Li Shuyuan Guo Caicai Meng Yuliang Xiao Source Type: research
Commercial compost amendments inhibit the bioavailability and plant uptake of per- and polyfluoroalkyl substances in soil-porewater-lettuce systems
This study examined how compost affects the bioavailability and uptake of eight PFAS (two ethers, three fluorotelomer sulfonates, and three perfluorosulfonates) by lettuce (Lactuca sativa) grown in commercial organic compost-amended, PFAS spiked soils. After 50 days of greenhouse experiment, PFAS uptake by lettuce decreased (by up to 90.5 %) with the increasing compost amendment ratios (0-20 %, w/w), consistent with their decreased porewater concentrations (by 30.7-86.3 %) in compost-amended soils. Decreased bioavailability of PFAS was evidenced by the increased in-situ soil-porewater distribution coefficients (Kd) (by fac...
Source: Environment International - April 6, 2024 Category: Environmental Health Authors: Yuanbo Li Yue Zhi Rebecca Weed Stephen W Broome Detlef R U Knappe Owen W Duckworth Source Type: research
TRPM7 facilitates fibroblast-like synoviocyte proliferation, metastasis and inflammation through increasing IL-6 stability via the PKC α-HuR axis in rheumatoid arthritis
In conclusion, our findings unveil a novel regulatory mechanism involved in the pathogenesis of RA and suggest that targeting TRPM7 might be a potential strategy for the prevention and treatment of RA.PMID:38581988 | DOI:10.1016/j.intimp.2024.111933 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 6, 2024 Category: Allergy & Immunology Authors: Yi Lin Yong Chen Weirong Hu Xingyu Liu Wenjuan Hao Jing Xing Jie Ding Yucai Xu Feng Yao Yingjie Zhao Ke Wang Shufang Li Qiuxia Yu Wei Hu Renpeng Zhou Source Type: research
Indole-3-carbinol ameliorates ovarian damage in female old mice through Nrf2/HO-1 pathway activation
In conclusion, I3C can alleviate the ovarian damage caused by aging and may be a protective agent to delay ovarian aging.PMID:38582268 | DOI:10.1016/j.bcp.2024.116193 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - April 6, 2024 Category: Drugs & Pharmacology Authors: Huiqing Hu Fangfang Li Fengyu Zhu Jun Li Siyuan Wang Zhuoying He Jiaqi Chen Linghui Cheng Fei Zhong Source Type: research
OLFACTORY tract/BULB metal CONCENTRATION in Manganese-EXPOSED mineWORKErs
CONCLUSIONS: Our findings suggest that Mn-exposed mineworkers might have higher olfactory tract/bulb tissue Mn concentrations than non-Mn exposed mineworkers, and that concentrations might depend more on cumulative dose than recency of exposure.PMID:38582332 | DOI:10.1016/j.neuro.2024.04.001 (Source: Neurotoxicology)
Source: Neurotoxicology - April 6, 2024 Category: Neurology Authors: Luis F Gonzalez-Cuyar Gill Nelson Susan Searles Nielsen Wendy W Dlamini Amelia Keyser-Gibson C Dirk Keene Michael Paulsen Susan R Criswell Natalie Senini Lianne Sheppard Shar Samy Christopher D Simpson Marissa G Baker Brad A Racette Source Type: research
Commercial compost amendments inhibit the bioavailability and plant uptake of per- and polyfluoroalkyl substances in soil-porewater-lettuce systems
This study examined how compost affects the bioavailability and uptake of eight PFAS (two ethers, three fluorotelomer sulfonates, and three perfluorosulfonates) by lettuce (Lactuca sativa) grown in commercial organic compost-amended, PFAS spiked soils. After 50 days of greenhouse experiment, PFAS uptake by lettuce decreased (by up to 90.5 %) with the increasing compost amendment ratios (0-20 %, w/w), consistent with their decreased porewater concentrations (by 30.7-86.3 %) in compost-amended soils. Decreased bioavailability of PFAS was evidenced by the increased in-situ soil-porewater distribution coefficients (Kd) (by fac...
Source: Environment International - April 6, 2024 Category: Environmental Health Authors: Yuanbo Li Yue Zhi Rebecca Weed Stephen W Broome Detlef R U Knappe Owen W Duckworth Source Type: research
