Activation of angiogenin expression in macrophages by lipopolysaccharide via the TLR4/NF- κB pathway in colitis
Acta Biochim Biophys Sin (Shanghai). 2024 Apr 3. doi: 10.3724/abbs.2024013. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD) is a debilitating condition that can lead to life-threatening complications. Macrophages are crucial in IBD management because they secrete various cytokines and regulate tissue repair. Macrophage-derived angiogenin (ANG) has been shown to be essential for limiting colonic inflammation, but its upstream regulatory pathway and role in macrophages remain unclear. Here we show that ANG expression is up-regulated in macrophages during colitis treatment or upon lipopolysaccharides (LPS) trea...
Source: Acta Biochimica et Biophysica Sinica - April 3, 2024 Category: Biochemistry Authors: Zhengrong Yao Rongpan Bai Wei Liu Yaxing Liu Wei Zhou Zhengping Xu Jinghao Sheng Source Type: research
Small-molecule targeting PKM2 provides a molecular basis of lactylation-dependent fibroblast-like synoviocytes proliferation inhibition against rheumatoid arthritis
Eur J Pharmacol. 2024 Apr 1:176551. doi: 10.1016/j.ejphar.2024.176551. Online ahead of print.ABSTRACTFibroblast-like synoviocytes (FLS) play an important role in rheumatoid arthritis (RA)-related swelling and bone damage. Therefore, novel targets for RA therapy in FLS are urgently discovered for improving pathologic phenomenon, especially joint damage and dyskinesia. Here, we suggested that pyruvate kinase M2 (PKM2) in FLS represented a pharmacological target for RA treatment by antimalarial drug artemisinin (ART). We demonstrated that ART selectively inhibited human RA-FLS and rat collagen-induced arthritis (CIA)-FLS prol...
Source: European Journal of Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Authors: Yan-Hang Wang Peng Gao Yu-Qi Wang Lu-Zheng Xu Ke-Wu Zeng Peng-Fei Tu Source Type: research
Microglial SCAP deficiency protects against diabetes-associated cognitive impairment through inhibiting NLRP3 inflammasome-mediated neuroinflammation
Brain Behav Immun. 2024 Apr 1:S0889-1591(24)00331-3. doi: 10.1016/j.bbi.2024.03.051. Online ahead of print.ABSTRACTHyperglycemia-induced pathological microglial responses and subsequent neuronal damage- are notable characteristics of diabetes-associated cognitive impairment (DACI). Cholesterol accumulation in the brain is a prevalent consequence of diabetes mellitus (DM), exacerbating pathological microglial responses. Regarding disordered glucose and lipid metabolism, the Sterol Regulatory Element-Binding Protein (SREBP) cleavage-activating protein (SCAP), a cholesterol sensor, exhibits increased expression and abnormal t...
Source: Brain, Behavior, and Immunity - April 3, 2024 Category: Neurology Authors: Wenwen Zhu Haoqiang Zhang Tong Niu Kunyu Liu Huzaifa Fareeduddin Mohammed Farooqui Ruoyu Sun Xiu Chen Yang Yuan Shaohua Wang Source Type: research
Corrigendum to "Nano zero-valent iron and melatonin synergistically alters uptake and translocation of Cd and As in soil-rice system and mechanism in soil chemistry and microbiology" [Environ. Int. 185 (2024) 108550]
Environ Int. 2024 Apr 2:108600. doi: 10.1016/j.envint.2024.108600. Online ahead of print.NO ABSTRACTPMID:38570290 | DOI:10.1016/j.envint.2024.108600 (Source: Environment International)
Source: Environment International - April 3, 2024 Category: Environmental Health Authors: Qiongli Bao Yinrong Bao Jiahao Shi Yuebing Sun Source Type: research
Na < sup > + < /sup > -Mg < sup > 2+ < /sup > ion effects on conformation and translocation dynamics of single-stranded RNA: Cooperation and competition
In this study, Langevin dynamics simulation is employed to investigate the properties of ssRNA conformation and translocation in mixed Na+-Mg2+ ion environments. Simulation results reveal that the ion screening effect dominates the change in the ssRNA conformational size, the ion neutralizing effect controls the capture rate of the ssRNA by the nanopore, and both of them take charge of the different changes in translocation time of the ssRNA under various mixed ion environments. Under high Na+ ion concentration, as Mg2+ concentration increases, the ion neutralizing effect strengthens, weakening the driving force inside the...
Source: International Journal of Biological Macromolecules - April 3, 2024 Category: Biochemistry Authors: Yi-Fan Rao Li-Zhen Sun Meng-Bo Luo Source Type: research
Activation of angiogenin expression in macrophages by lipopolysaccharide via the TLR4/NF- κB pathway in colitis
Acta Biochim Biophys Sin (Shanghai). 2024 Apr 3. doi: 10.3724/abbs.2024013. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD) is a debilitating condition that can lead to life-threatening complications. Macrophages are crucial in IBD management because they secrete various cytokines and regulate tissue repair. Macrophage-derived angiogenin (ANG) has been shown to be essential for limiting colonic inflammation, but its upstream regulatory pathway and role in macrophages remain unclear. Here we show that ANG expression is up-regulated in macrophages during colitis treatment or upon lipopolysaccharides (LPS) trea...
Source: Acta Biochimica et Biophysica Sinica - April 3, 2024 Category: Biochemistry Authors: Zhengrong Yao Rongpan Bai Wei Liu Yaxing Liu Wei Zhou Zhengping Xu Jinghao Sheng Source Type: research
Conformational changes of ribosomes during translation elongation resolved by molecular dynamics simulations
Curr Opin Struct Biol. 2024 Apr 2;86:102804. doi: 10.1016/j.sbi.2024.102804. Online ahead of print.ABSTRACTMolecular dynamics simulations have emerged as a powerful set of tools to unravel the intricate dynamics of ribosomes during protein synthesis. Recent advancements in this field have enabled simulations to delve deep into the conformational rearrangements of ribosomes and associated factors, providing invaluable insights into the intricacies of translation. Emphasis on simulations has recently been on translation elongation, such as tRNA selection, translocation, and ribosomal head-swivel motions. These studies have o...
Source: Current Opinion in Structural Biology - April 3, 2024 Category: Biology Authors: Anuradha Rai Chowdhury Divya Sapkota Dylan Girodat Source Type: research
Iterative oxidation by TET1 is required for reprogramming of imprinting control regions and patterning of mouse sperm hypomethylated regions
Dev Cell. 2024 Apr 1:S1534-5807(24)00144-8. doi: 10.1016/j.devcel.2024.02.012. Online ahead of print.ABSTRACTTen-eleven translocation (TET) enzymes iteratively oxidize 5-methylcytosine (5mC) to generate 5-hydroxymethylcytosine (5hmC), 5-formylcytosine, and 5-carboxylcytosine to facilitate active genome demethylation. Whether these bases are required to promote replication-coupled dilution or activate base excision repair during mammalian germline reprogramming remains unresolved due to the inability to decouple TET activities. Here, we generated two mouse lines expressing catalytically inactive TET1 (Tet1-HxD) and TET1 tha...
Source: Developmental Cell - April 3, 2024 Category: Cytology Authors: Rexxi D Prasasya Blake A Caldwell Zhengfeng Liu Songze Wu N Adrian Leu Johanna M Fowler Steven A Cincotta Diana J Laird Rahul M Kohli Marisa S Bartolomei Source Type: research
Small-molecule targeting PKM2 provides a molecular basis of lactylation-dependent fibroblast-like synoviocytes proliferation inhibition against rheumatoid arthritis
Eur J Pharmacol. 2024 Apr 1:176551. doi: 10.1016/j.ejphar.2024.176551. Online ahead of print.ABSTRACTFibroblast-like synoviocytes (FLS) play an important role in rheumatoid arthritis (RA)-related swelling and bone damage. Therefore, novel targets for RA therapy in FLS are urgently discovered for improving pathologic phenomenon, especially joint damage and dyskinesia. Here, we suggested that pyruvate kinase M2 (PKM2) in FLS represented a pharmacological target for RA treatment by antimalarial drug artemisinin (ART). We demonstrated that ART selectively inhibited human RA-FLS and rat collagen-induced arthritis (CIA)-FLS prol...
Source: European Journal of Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Authors: Yan-Hang Wang Peng Gao Yu-Qi Wang Lu-Zheng Xu Ke-Wu Zeng Peng-Fei Tu Source Type: research
Microglial SCAP deficiency protects against diabetes-associated cognitive impairment through inhibiting NLRP3 inflammasome-mediated neuroinflammation
Brain Behav Immun. 2024 Apr 1:S0889-1591(24)00331-3. doi: 10.1016/j.bbi.2024.03.051. Online ahead of print.ABSTRACTHyperglycemia-induced pathological microglial responses and subsequent neuronal damage- are notable characteristics of diabetes-associated cognitive impairment (DACI). Cholesterol accumulation in the brain is a prevalent consequence of diabetes mellitus (DM), exacerbating pathological microglial responses. Regarding disordered glucose and lipid metabolism, the Sterol Regulatory Element-Binding Protein (SREBP) cleavage-activating protein (SCAP), a cholesterol sensor, exhibits increased expression and abnormal t...
Source: Brain, Behavior, and Immunity - April 3, 2024 Category: Neurology Authors: Wenwen Zhu Haoqiang Zhang Tong Niu Kunyu Liu Huzaifa Fareeduddin Mohammed Farooqui Ruoyu Sun Xiu Chen Yang Yuan Shaohua Wang Source Type: research
Corrigendum to "Nano zero-valent iron and melatonin synergistically alters uptake and translocation of Cd and As in soil-rice system and mechanism in soil chemistry and microbiology" [Environ. Int. 185 (2024) 108550]
Environ Int. 2024 Apr 2:108600. doi: 10.1016/j.envint.2024.108600. Online ahead of print.NO ABSTRACTPMID:38570290 | DOI:10.1016/j.envint.2024.108600 (Source: Environment International)
Source: Environment International - April 3, 2024 Category: Environmental Health Authors: Qiongli Bao Yinrong Bao Jiahao Shi Yuebing Sun Source Type: research
Activation of angiogenin expression in macrophages by lipopolysaccharide via the TLR4/NF- κB pathway in colitis
Acta Biochim Biophys Sin (Shanghai). 2024 Apr 3. doi: 10.3724/abbs.2024013. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD) is a debilitating condition that can lead to life-threatening complications. Macrophages are crucial in IBD management because they secrete various cytokines and regulate tissue repair. Macrophage-derived angiogenin (ANG) has been shown to be essential for limiting colonic inflammation, but its upstream regulatory pathway and role in macrophages remain unclear. Here we show that ANG expression is up-regulated in macrophages during colitis treatment or upon lipopolysaccharides (LPS) trea...
Source: Acta Biochimica et Biophysica Sinica - April 3, 2024 Category: Biochemistry Authors: Zhengrong Yao Rongpan Bai Wei Liu Yaxing Liu Wei Zhou Zhengping Xu Jinghao Sheng Source Type: research
Conformational changes of ribosomes during translation elongation resolved by molecular dynamics simulations
Curr Opin Struct Biol. 2024 Apr 2;86:102804. doi: 10.1016/j.sbi.2024.102804. Online ahead of print.ABSTRACTMolecular dynamics simulations have emerged as a powerful set of tools to unravel the intricate dynamics of ribosomes during protein synthesis. Recent advancements in this field have enabled simulations to delve deep into the conformational rearrangements of ribosomes and associated factors, providing invaluable insights into the intricacies of translation. Emphasis on simulations has recently been on translation elongation, such as tRNA selection, translocation, and ribosomal head-swivel motions. These studies have o...
Source: Current Opinion in Structural Biology - April 3, 2024 Category: Biology Authors: Anuradha Rai Chowdhury Divya Sapkota Dylan Girodat Source Type: research
Microglial SCAP deficiency protects against diabetes-associated cognitive impairment through inhibiting NLRP3 inflammasome-mediated neuroinflammation
Brain Behav Immun. 2024 Apr 2;119:154-170. doi: 10.1016/j.bbi.2024.03.051. Online ahead of print.ABSTRACTHyperglycemia-induced pathological microglial responses and subsequent neuronal damage are notable characteristics of diabetes-associated cognitive impairment (DACI). Cholesterol accumulation in the brain is a prevalent consequence of diabetes mellitus (DM), exacerbating pathological microglial responses. Regarding disordered glucose and lipid metabolism, the Sterol Regulatory Element-Binding Protein (SREBP) cleavage-activating protein (SCAP), a cholesterol sensor, exhibits increased expression and abnormal translocatio...
Source: Brain, Behavior, and Immunity - April 3, 2024 Category: Neurology Authors: Wenwen Zhu Haoqiang Zhang Tong Niu Kunyu Liu Huzaifa Fareeduddin Mohammed Farooqui Ruoyu Sun Xiu Chen Yang Yuan Shaohua Wang Source Type: research
Activation of angiogenin expression in macrophages by lipopolysaccharide via the TLR4/NF- κB pathway in colitis
Acta Biochim Biophys Sin (Shanghai). 2024 Apr 3. doi: 10.3724/abbs.2024013. Online ahead of print.ABSTRACTInflammatory bowel disease (IBD) is a debilitating condition that can lead to life-threatening complications. Macrophages are crucial in IBD management because they secrete various cytokines and regulate tissue repair. Macrophage-derived angiogenin (ANG) has been shown to be essential for limiting colonic inflammation, but its upstream regulatory pathway and role in macrophages remain unclear. Here we show that ANG expression is up-regulated in macrophages during colitis treatment or upon lipopolysaccharides (LPS) trea...
Source: Acta Biochimica et Biophysica Sinica - April 3, 2024 Category: Biochemistry Authors: Zhengrong Yao Rongpan Bai Wei Liu Yaxing Liu Wei Zhou Zhengping Xu Jinghao Sheng Source Type: research
