Proteogenomics of Breast Cancer
NCI's Center for Cancer Research (CCR) Grand Rounds
Dr. Matthew Ellis ’ s clinical and basic research focuses on breast cancer. He has developed neoadjuvant endocrine therapy as an alternative to chemotherapy for promoting breast-conserving therapy in postmenopausal women with ER+ HER2- stage 2 and 3 disease. He developed and validated the Ki67 proliferation marker-based Preoperative Endocrine Prognostic Index which is now undergoing a large validation study (the ALTERNATE study). These clinical studies have provided the clinical context and tumor specimens for seminal investigations into the ER+ breast cancer somatic ge...
Source: Videocast - All Events - January 30, 2018 Category: General Medicine Tags: Upcoming Events Source Type: video
Principles of Epigenetics and Chromatin in Development and Human Disease
NCI ’ s Center for Cancer Research (CCR) Grand Rounds
Dr. Ali Shilatifard, Professor and Chairman of the Department of Biochemistry and Molecular Genetics of the Northwestern University Feinberg School of Medicine, is a world renown biochemist and molecular biologist. He is a respected expert in the field of transcription and epigenetics, specifically as it relates to cancer biology. He has an immense interest in understanding the intricate molecular mechanisms of the regulation of gene expression, the mechanisms that activate or suppress a particular gene ’ s traits. As a Jane Coffin Childs postdoctoral fellow, Dr. Sh...
Source: Videocast - All Events - October 23, 2017 Category: General Medicine Tags: Upcoming Events Source Type: video
Multifaceted Functions of Mitochondria in Neuronal Synapses
Director's Seminar Series
The Section on Synapse Development and Synaptic Plasticity led by Dr. Zheng Li is interested in the molecular and cellular mechanisms underlying synapse development and synaptic plasticity in normal brains and synaptopathology associated with psychiatric disorders. Our research shows that mitochondria, the vital organelles in eukaryotic cells, not only are essential for the general cell physiology, but also play multifaceted roles in synapses. In hippocampal neurons, the quantify of mitochondria in dendrites determines the density of synapses and dendritic spines. Mitochondria are permeabilized up...
Source: Videocast - All Events - April 17, 2017 Category: Journals (General) Tags: Upcoming Events Source Type: video
Structural and mechanistic diversity of ABC transporters
Wednesday Afternoon Lecture Series
ATP Binding Cassette (ABC) transporters constitute a ubiquitous superfamily of integral membrane proteins responsible for the ATP powered membrane translocation of a wide variety of substrates. The highly conserved ABC domains defining the superfamily provide the nucleotide-powered engine that drives transport. In contrast, the transmembrane domains creating the translocation pathway are more variable, with three distinct folds currently recognized. Structural analyses of the high affinity methionine MetNI importer and of a bacterial homologue of the mitochondrial Atm1 exporter will be d...
Source: Videocast - All Events - March 3, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
Demystifying Medicine 2014-Chromosomal Translocation: Cellular Mechanism and Clinical Consequences
Presented by: Tom Misteli, PhD (NCI) John Barrett, MD (NHLBI)Category: Demystifying MedicineAired date: 02/25/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - February 27, 2014 Category: Journals (General) Tags: Past Events Source Type: video
Demystifying Medicine 2014 - Chromosomal Translocation: Cellular Mechanism and Clinical Consequences
Presented by: Tom Misteli, PhD (NCI) John Barrett, MD (NHLBI)Category: Demystifying MedicineAired date: 02/25/2014 (Source: Videocast - All Events)
Source: Videocast - All Events - February 27, 2014 Category: Journals (General) Tags: Past Events Source Type: video
Demystifying Medicine 2014-Chromosomal Translocation: Cellular Mechanism and Clinical Consequences
The 2014 Demystifying Medicine Series, which is jointly sponsored by FAES and NIH, will begin January 7th and includes the presentation of patients, pathology, diagnosis and therapy in the context of major disease problems and current research. Primarily directed toward Ph.D. students, clinicians and program managers, the course is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components presented by NIH staff and invitees. All students, fellows and staff are welcome, as well. For more information go to http://demy...
Source: Videocast - All Events - January 6, 2014 Category: Journals (General) Tags: Upcoming Events Source Type: video
