Proteogenomics of Breast Cancer

NCI's Center for Cancer Research (CCR) Grand Rounds Dr. Matthew Ellis ’ s clinical and basic research focuses on breast cancer. He has developed neoadjuvant endocrine therapy as an alternative to chemotherapy for promoting breast-conserving therapy in postmenopausal women with ER+ HER2- stage 2 and 3 disease. He developed and validated the Ki67 proliferation marker-based Preoperative Endocrine Prognostic Index which is now undergoing a large validation study (the ALTERNATE study). These clinical studies have provided the clinical context and tumor specimens for seminal investigations into the ER+ breast cancer somatic genome, with insights into massive clonal heterogeneity, new tumor suppressor gene discovery specific to ER+ disease and new therapeutic targets. These include activating mutations in the HER2 gene that Dr. Ellis has shown respond to HER2 kinase inhibition in clinical trials. He also pioneered patient-derived xenograft research (PDX). A PDX study in triple negative breast cancer revealed clonal remodeling during brain metastasis. PDX analysis also revealed that acquired resistance to endocrine therapy is a consequence of ESR1 ligand-binding mutation; ESR1 amplification and most uniquely chromosomal translocation causing fusions between the N terminus of ESR1 and the C-terminus of genes that can confer constitutive transcriptional activity. The ability to understand the complex somatic genomes was enhanced though Dr. Ellis ’ s work with the Clinical P...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video

Related Links:

Publication date: October 2018Source: The Lancet Neurology, Volume 17, Issue 10Author(s): Maria A Rocca, Frederik Barkhof, John De Luca, Jonas Frisén, Jeroen J G Geurts, Hanneke E Hulst, Jaume Sastre-Garriga, Massimo Filippi, Frederik Barkhof, Olga Ciccarelli, Nicola De Stefano, Christian Enzinger, Massimo Filippi, Jette L. Frederiksen, Claudio Gasperini, Ludwig Kappos, Jacqueline Palace, Maria A. Rocca, Alex Rovira, Jaume Sastre-GarrigaSummarySome of the clinical manifestations of multiple sclerosis, such as memory impairment and depression, are, at least partly, related to involvement of the hippocampus. Pathologi...
Source: The Lancet Neurology - Category: Neurology Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Carrageenan is a controversial food additive. It is FDA-approved, but some scientists believe that it can cause inflammation, bowel disorders, and even certain cancers. In this article, we look at the research behind carrageenan, including its possible side effects, dangers, uses, and common foods that contain it.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Nutrition / Diet Source Type: news
Pancreatic cancer and NanotechnologyFor more information go tohttp://ccr.cancer.gov/training/trainee-resources/courses-workshops/tracoAir date: 12/3/2018 4:00:00 PM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Epigenetics and HIVFor more information go tohttp://ccr.cancer.gov/training/trainee-resources/courses-workshops/tracoAir date: 11/26/2018 4:00:00 PM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
K-RAS and Chaperone proteinsFor more information go tohttp://ccr.cancer.gov/training/trainee-resources/courses-workshops/tracoAir date: 11/19/2018 4:00:00 PM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Non-small cell lung cancer and GenomicsFor more information go tohttp://ccr.cancer.gov/training/trainee-resources/courses-workshops/tracoAir date: 11/5/2018 4:00:00 PM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Topoisomerases and Precision medicineFor more information go tohttp://ccr.cancer.gov/training/trainee-resources/courses-workshops/tracoAir date: 10/29/2018 4:00:00 PM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
Cases of severe infections from the amoeba N. fowleri are rare — but there’s currently no way to stop the disease and it is almost always fatal.
Source: PharmaManufacturing.com - Category: Pharmaceuticals Source Type: news
Breast cancer and EpidemiologyFor more information go tohttp://ccr.cancer.gov/training/trainee-resources/courses-workshops/tracoAir date: 10/22/2018 4:00:00 PM
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
More News: Brain | Brain Cancers | Breast Cancer | Breast Conservation Surgery | Canada Health | Cancer | Cancer & Oncology | Chemotherapy | Clinical Trials | Endocrine Therapy | Gastroschisis Repair | General Medicine | Genetics | Grants | HER2 | Laboratory Medicine | Neoadjuvant Chemotherapy Therapy | Neoadjuvant Therapy | Neurology | Study | Translocation | Women