Proteogenomics of Breast Cancer

NCI's Center for Cancer Research (CCR) Grand Rounds Dr. Matthew Ellis ’ s clinical and basic research focuses on breast cancer. He has developed neoadjuvant endocrine therapy as an alternative to chemotherapy for promoting breast-conserving therapy in postmenopausal women with ER+ HER2- stage 2 and 3 disease. He developed and validated the Ki67 proliferation marker-based Preoperative Endocrine Prognostic Index which is now undergoing a large validation study (the ALTERNATE study). These clinical studies have provided the clinical context and tumor specimens for seminal investigations into the ER+ breast cancer somatic genome, with insights into massive clonal heterogeneity, new tumor suppressor gene discovery specific to ER+ disease and new therapeutic targets. These include activating mutations in the HER2 gene that Dr. Ellis has shown respond to HER2 kinase inhibition in clinical trials. He also pioneered patient-derived xenograft research (PDX). A PDX study in triple negative breast cancer revealed clonal remodeling during brain metastasis. PDX analysis also revealed that acquired resistance to endocrine therapy is a consequence of ESR1 ligand-binding mutation; ESR1 amplification and most uniquely chromosomal translocation causing fusions between the N terminus of ESR1 and the C-terminus of genes that can confer constitutive transcriptional activity. The ability to understand the complex somatic genomes was enhanced though Dr. Ellis ’ s work with the Clinical P...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video

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Source: MedPage Today Hematology/Oncology - Category: Hematology Source Type: news
Authors: Jing LW, Zhang C, Jin F, Wang AP Abstract BACKGROUND There is a great need for a quality of sexual life questionnaire (QVS) in breast cancer survivors (BCSs) based on the Chinese social culture since the imported tools lack localization verification. To develop a QVS in BCSs and determine its validity and reliability. MATERIAL AND METHODS In the qualitative study, a total of 21 BCSs were interviewed by purposive sampling and snowball sampling; and in the quantitative study, a total of 249 BCSs, who were admitted and received outpatient follow-up, were investigated. Regarding construct validity, factor anal...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Authors: Turhan E, Yasli G Abstract OBJECTIVE: The present study was performed to detect cancer risk of the midwifes and nurses playing central role in raising awareness in the society using Gail's model. MATERIALS AND METHODS: Sample of the present cross sectional study consists of 750 volunteer midwifes and nurses in 2016. Breast cancer risk was calculated using the Gail Risk Assessment Tool. Perceived and calculated risk levels were compared. Descriptive statistics and Chi-Square analysis, t-test, Multivariate Linear Regression Analysis, the Logistic Regression Analysis were conducted. RESULTS: A mean of...
Source: Puerto Rico Health Sciences Journal - Category: International Medicine & Public Health Tags: P R Health Sci J Source Type: research
CONCLUSIONS AND RELEVANCE: Red eyes, conjunctivitis, and anterior uveitis occur frequently in patients with Chikungunya fever. Systemic diseases, such as diabetes, hypertension, and cancer, may increase the risk of such ocular manifestations. Routine ophthalmic evaluation is warranted in patients with these medical conditions. The relevance of this study lies in the fact that this disease remains an important public health issue, since such ocular sequelae as may be present can range from mild to severe, either as an acute or a delayed manifestation. PMID: 29905918 [PubMed - in process]
Source: Puerto Rico Health Sciences Journal - Category: International Medicine & Public Health Tags: P R Health Sci J Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
PROSTATE cancer happens when problems in an area of the male reproductive system cause cells to start dividing uncontrollably. You ’re more at risk of prostate cancer if you’re older, overweight or have a family history of the cancer. However, eating this red food can help you prevent the condition.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSIONS: It is possible to find changes at the level of retinal pigment epithelium, as well as vascular tortuosity, retinopathy associated with cancer, and choroidal and/or retina metastases. PMID: 29907347 [PubMed - as supplied by publisher]
Source: Archivos de la Sociedad Espanola de Oftalmologia - Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research
As is often the case when flying I was rewarded for offering a greeting to my row mate on the plane with a bit of insight and knowledge I’d have missed had I not simply reached out a hand and said, “Hi, I’m Darrell.” My momentary companion (we each moved to more spacious seats) had been a schoolmate of the recently deceased Kate Spade. He confirmed her years-long struggle with a depression that defied logic and was thus a depression that was as pathological as diabetes or heart disease or cancer. Opening my Sunday papers brings stories from the friends of Anthony Bourdain, also deceased, and his dec...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Psychiatry Source Type: blogs
SUNDAY, June 17, 2018 -- While some might be wary about the cancer risks of searing a steak on a flaming grill, a few simple changes can lower that risk, a nutritionist advises. Cooking beef, pork, fish or poultry over high temperatures can lead to...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
CONCLUSIONS: Thyroid Cancer Treatment Choice is an evidence-based tool that supports the presentation of treatment options for PMCs. Pilot testing suggests that this conversation tool increases acceptance of active surveillance, suggesting that this option is an acceptable and preferable alternative for informed patients. Further studies are warranted to confirm this finding. PMID: 29905089 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
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