Multiple and hereditary renal tumors: a review for radiologists
Radiologia (Engl Ed). 2024 Mar-Apr;66(2):132-154. doi: 10.1016/j.rxeng.2024.03.001. Epub 2024 Mar 23.ABSTRACT80% of renal carcinomas (RC) are diagnosed incidentally by imaging. 2-4% of "sporadic" multifocality and 5-8% of hereditary syndromes are accepted, probably with underestimation. Multifocality, young age, familiar history, syndromic data, and certain histologies lead to suspicion of hereditary syndrome. Each tumor must be studied individually, with a multidisciplinary evaluation of the patient. Nephron-sparing therapeutic strategies and a radioprotective diagnostic approach are recommended. Relevant data for the rad...
Source: Radiologia - April 13, 2024 Category: Radiology Authors: M Á Corral de la Calle J Encinas de la Iglesia G C Fern ández Pérez A Fraino M Repoll és Cobaleda Source Type: research
Multiple and hereditary renal tumors: a review for radiologists
Radiologia (Engl Ed). 2024 Mar-Apr;66(2):132-154. doi: 10.1016/j.rxeng.2024.03.001. Epub 2024 Mar 23.ABSTRACT80% of renal carcinomas (RC) are diagnosed incidentally by imaging. 2-4% of "sporadic" multifocality and 5-8% of hereditary syndromes are accepted, probably with underestimation. Multifocality, young age, familiar history, syndromic data, and certain histologies lead to suspicion of hereditary syndrome. Each tumor must be studied individually, with a multidisciplinary evaluation of the patient. Nephron-sparing therapeutic strategies and a radioprotective diagnostic approach are recommended. Relevant data for the rad...
Source: Radiologia - April 13, 2024 Category: Radiology Authors: M Á Corral de la Calle J Encinas de la Iglesia G C Fern ández Pérez A Fraino M Repoll és Cobaleda Source Type: research
Genotype and phenotype in patients with ACAN gene variants: Three cases and literature review
ConclusionOur study achieves a new understanding of the phenotypic spectrum, diagnosis, and management of individuals withACAN variants. No clear genotype –phenotype relationship of patients withACAN variants was found. Gene sequencing is necessary to diagnoseACAN variants that cause short stature. In general, appropriate rhGH and/or GnRHa therapy can improve the adult height of affected pediatric patients caused byACAN variants. (Source: Molecular Genetics & Genomic Medicine)
Source: Molecular Genetics & Genomic Medicine - April 13, 2024 Category: Genetics & Stem Cells Authors: Wei Tang,
Ke ‐Mi Wu,
Qiong Zhou,
Yan‐Fei Tang,
Jun‐Fen Fu,
Guan‐Ping Dong,
Chao‐Chun Zou Tags: ORIGINAL ARTICLE Source Type: research
GSE243667 Increased AID Results in Mutations at the CRLF2 Locus Implicated in Latin American ALL Health Disparities
Contributors : Richard L Frock ; Valeria Rangel ; Jason N Sterrenberg ; Nicholas R PannunzioSeries Type : OtherOrganism : Homo sapiensActivation-induced cytidine deaminase (AID) is a B cell-specific base editor required during class switch recombination and somatic hypermutation for B cell maturation and antibody diversification. However, it has also been implicated as a factor in the etiology of several B cell malignancies. Evaluating the AID-induced mutation load in patients at-risk for certain types of blood cancers is critical in assessing disease severity and treatment options. Here, we have developed a digital PCR (...
Source: GEO: Gene Expression Omnibus - April 13, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
STAT3 promotes cytoplasmic-nuclear translocation of RNA-binding protein HuR to inhibit IL-1 β-induced IL-8 production
We report here that STAT3 inhibitors Stattic and Niclosamide up-regulated IL-1β-induced IL-8 production in C33A, CaSki, and Siha cervical cancer cells. As expected, IL-1β-induced IL-8 production was also up-regulated through the molecular inhibition of STAT3 by use of CRISPR/Cas9 technology. Unexpectedly, IL-1β induced IL-8 production via activating ERK and P38 signal pathways, but neither STAT3 inhibitors nor STAT3 knockout affected IL-1β-induced signal transduction, suggesting that STAT3 decreases IL-8 production not via inhibition of signal transduction. To our surprise, STAT3 inhibition increased the stabilization,...
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Jiangwen Long Wang Zhao Yangen Xiang Yufei Wang Wei Xiang Xueting Liu Manli Jiang Yinghui Song Jinyue Hu Source Type: research
Retrieval of Trophoblast Cells from The Robertsonian Translocations for Prenatal Diagnosis
CONCLUSION: The collection of fetal trophoblast cells from the cervix provides a feasible approach for prenatal diagnosis. Rob translocation homozygosity could be seen as a potential means of speciation in humans with 44 chromosomes.PMID:38607200 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Zhen Xu Sheng Li Long He Source Type: research
STAT3 promotes cytoplasmic-nuclear translocation of RNA-binding protein HuR to inhibit IL-1 β-induced IL-8 production
We report here that STAT3 inhibitors Stattic and Niclosamide up-regulated IL-1β-induced IL-8 production in C33A, CaSki, and Siha cervical cancer cells. As expected, IL-1β-induced IL-8 production was also up-regulated through the molecular inhibition of STAT3 by use of CRISPR/Cas9 technology. Unexpectedly, IL-1β induced IL-8 production via activating ERK and P38 signal pathways, but neither STAT3 inhibitors nor STAT3 knockout affected IL-1β-induced signal transduction, suggesting that STAT3 decreases IL-8 production not via inhibition of signal transduction. To our surprise, STAT3 inhibition increased the stabilization,...
Source: International Immunopharmacology - April 12, 2024 Category: Allergy & Immunology Authors: Jiangwen Long Wang Zhao Yangen Xiang Yufei Wang Wei Xiang Xueting Liu Manli Jiang Yinghui Song Jinyue Hu Source Type: research
Retrieval of Trophoblast Cells from The Robertsonian Translocations for Prenatal Diagnosis
CONCLUSION: The collection of fetal trophoblast cells from the cervix provides a feasible approach for prenatal diagnosis. Rob translocation homozygosity could be seen as a potential means of speciation in humans with 44 chromosomes.PMID:38607200 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Zhen Xu Sheng Li Long He Source Type: research
Retrieval of Trophoblast Cells from The Robertsonian Translocations for Prenatal Diagnosis
CONCLUSION: The collection of fetal trophoblast cells from the cervix provides a feasible approach for prenatal diagnosis. Rob translocation homozygosity could be seen as a potential means of speciation in humans with 44 chromosomes.PMID:38607200 (Source: Alternative Therapies in Health and Medicine)
Source: Alternative Therapies in Health and Medicine - April 12, 2024 Category: Complementary Medicine Authors: Zhen Xu Sheng Li Long He Source Type: research
The components of the AhR ‐molecular chaperone complex differ depending on whether the ligands are toxic or non‐toxic
When bound to toxic or non-toxic ligands, aryl hydrocarbon receptors (AhRs) are activated and nuclear translocation occurs; AhRs are bound to molecular chaperone complexes, AhR-HSP90-XAP2-p23 for toxic ligands, whereas for non-toxic ligands AhR-HSP90- XAP2 for non-toxic ligands. Toxic and non-toxic ligand selectivity of AhR depends on the components of the molecular chaperone complex. The aryl hydrocarbon receptor (AhR) forms a complex with the HSP90-XAP2-p23 molecular chaperone when the cells are exposed to toxic compounds. Recently, 1,4-dihydroxy-2-naphthoic acid (DHNA) was reported to be an AhR ligand. Here, we investig...
Source: FEBS Letters - April 12, 2024 Category: Biochemistry Authors: Yukihiko Narita,
Arisa Tamura,
Shiori Hatakeyama,
Seiya Uemura,
Atsuko Miura,
Asami Haga,
Noriko Tsuji,
Nozomi Fujie,
Yukina Izumi,
Taku Sugawara,
Michiro Otaka,
Ken Okamoto,
Peng Lu,
Suguru Okuda,
Michio Suzuki,
Koji Nagata,
Hiroaki Shimi Tags: Research Letter Source Type: research
Downregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration
ConclusionThe findings from this study demonstrate the anticancer activity of GPX8 in HCC by inactivating the Hsc70/AKT pathway. The results suggest a possible therapeutic target for HCC. (Source: Cellular Oncology)
Source: Cellular Oncology - April 12, 2024 Category: Cancer & Oncology Source Type: research
Urea promoted soil microbial community and reduced the residual ciprofloxacin in soil and its uptake by Chinese flowering cabbage
In conclusion, moderate urea addition significantly increased soil microbial activity and abundance, which in turn promoted the ciprofloxacin dissipation in soil and plant tissue. The present study provides an economical and operational strategy for the remediation of ciprofloxacin contaminated soils.PMID:38602632 | DOI:10.1007/s11356-024-33213-0 (Source: Environmental Science and Pollution Research International)
Source: Environmental Science and Pollution Research International - April 11, 2024 Category: Environmental Health Authors: Xiaolian Wu Chenze Jin Gengying Du Jianan Wang Jiayi Su Rongxuan Li Source Type: research
Prokaryotic communities of the French Polynesian sponge Dactylospongia metachromia display a site-specific and stable diversity during an aquaculture trial
Antonie Van Leeuwenhoek. 2024 Apr 11;117(1):65. doi: 10.1007/s10482-024-01962-0.ABSTRACTDynamics of microbiomes through time are fundamental regarding survival and resilience of their hosts when facing environmental alterations. As for marine species with commercial applications, such as marine sponges, assessing the temporal change of prokaryotic communities allows us to better consider the adaptation of sponges to aquaculture designs. The present study aims to investigate the factors shaping the microbiome of the sponge Dactylospongia metachromia, in a context of aquaculture development in French Polynesia, Rangiroa, Tua...
Source: Antonie van Leeuwenhoek - April 11, 2024 Category: Microbiology Authors: Mathilde Maslin Beno ît Paix Niels van der Windt Rohani Ambo-Rappe C écile Debitus Nabila Gaertner-Mazouni Raimana Ho Nicole J de Voogd Source Type: research
Talk to your neighbors in an emergency: Stromule-mediated chloroplast-nucleus communication in plant immunity
Curr Opin Plant Biol. 2024 Apr 10;79:102529. doi: 10.1016/j.pbi.2024.102529. Online ahead of print.ABSTRACTHypersensitive response-programmed cell death (HR-PCD) is a response mounted by plants to defend themselves against pathogens. Communication between the chloroplast and the nucleus is critical for the progression of HR-PCD. Tubular protrusions of chloroplasts, known as stromules, are tightly associated with the HR-PCD progression. There is emerging evidence that signaling molecules originating from chloroplasts are transferred to the nucleus through stromules. The translocation of signaling molecules from the chloropl...
Source: Current Opinion in Plant Biology - April 11, 2024 Category: Biology Authors: Seungmee Jung Jongchan Woo Eunsook Park Source Type: research
GPCR kinase subtype requirements for arrestin-2 and -3 translocation to the type-1 cannabinoid receptor and the consequences on G protein signalling
This study supports the hypothesis that arrestin-biased ligands for CB1 must engage GRK5/6 rather than GRK2/3, and G protein-biased ligands must have inherently low efficacy.PMID:38604257 | DOI:10.1016/j.bcp.2024.116190 (Source: Biochemical Pharmacology)
Source: Biochemical Pharmacology - April 11, 2024 Category: Drugs & Pharmacology Authors: Jamie J Manning David B Finlay Michelle Glass Source Type: research
