TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease
In this study, we found that TXNIP knockout suppressed renal fibrosis and activation of mammalian target of rapamycin complex 1 (mTORC1) and restored transcription factor EB (TFEB) and autophagy activation in diabetic kidneys. Simultaneously, TXNIP interference inhibited epithelial-to-mesenchymal transformation (EMT), collagen I and fibronectin expression, and mTORC1 activation, increased TFEB nuclear translocation, and promoted autophagy restoration in HK-2 cells exposed to high glucose (HG). Rapamycin, an inhibitor of mTORC1, increased TFEB nuclear translocation and autophagy in HK-2 cells under HG conditions. Moreover, ...
Source: Renal Failure - April 14, 2024 Category: Urology & Nephrology Authors: Yunxia Du Ming Wu Shan Song Yawei Bian Yonghong Shi Source Type: research
Cerium Oxide and Neodymium Oxide Phytoextraction by Ryegrass in Bioenhanced Hydroponic Environments
In this study, the effect of biostimulation and bioaugmentation on phytorecovery of REE nanoparticles (REE-NP) was investigated by exposing ryegrass seeds to REE-NP in hydroponic environments. This was studied in two sets of experiments: bioaugmentation (using CeO2 nanoparticles and Methylobacterium extorquens AM1 pure culture), and biostimulation (using CeO2 or Nd2O3 nanoparticles and endogenous microorganisms). Addition of M. extorquens AM1 in bioaugmentation experiment including 500 mg/L CeO2 nanoparticles could not promote the nanoparticles accumulation in both natural and surface-sterilized treatments. However, it enh...
Source: Environmental Pollution - April 14, 2024 Category: Environmental Health Authors: Maedeh Soleimanifar Lucia Rodriguez-Freire Source Type: research
Optimizing properties of translocation-enhancing transmembrane proteins
In this study, we demonstrate that specific properties of transmembrane proteins/peptides can enhance membrane permeation of amphiphilic peptides. Using coarse-grained molecular dynamics with free energy calculations, we identify key translocation-enhancing attributes of transmembrane proteins/peptides: a continuous hydrophilic patch, charged residues preferably in the membrane center, and aromatic hydrophobic residues. By employing both coarse-grained and atomistic simulations, complemented by experimental validation, we show that these properties not only enhance peptide translocation but also speed up lipid flip-flop. T...
Source: Biophysical Journal - April 14, 2024 Category: Physics Authors: Ladislav Barto š Martina Drabinov á Robert V ácha Source Type: research
TXNIP deficiency attenuates renal fibrosis by modulating mTORC1/TFEB-mediated autophagy in diabetic kidney disease
In this study, we found that TXNIP knockout suppressed renal fibrosis and activation of mammalian target of rapamycin complex 1 (mTORC1) and restored transcription factor EB (TFEB) and autophagy activation in diabetic kidneys. Simultaneously, TXNIP interference inhibited epithelial-to-mesenchymal transformation (EMT), collagen I and fibronectin expression, and mTORC1 activation, increased TFEB nuclear translocation, and promoted autophagy restoration in HK-2 cells exposed to high glucose (HG). Rapamycin, an inhibitor of mTORC1, increased TFEB nuclear translocation and autophagy in HK-2 cells under HG conditions. Moreover, ...
Source: Renal Failure - April 14, 2024 Category: Urology & Nephrology Authors: Yunxia Du Ming Wu Shan Song Yawei Bian Yonghong Shi Source Type: research
Cerium Oxide and Neodymium Oxide Phytoextraction by Ryegrass in Bioenhanced Hydroponic Environments
In this study, the effect of biostimulation and bioaugmentation on phytorecovery of REE nanoparticles (REE-NP) was investigated by exposing ryegrass seeds to REE-NP in hydroponic environments. This was studied in two sets of experiments: bioaugmentation (using CeO2 nanoparticles and Methylobacterium extorquens AM1 pure culture), and biostimulation (using CeO2 or Nd2O3 nanoparticles and endogenous microorganisms). Addition of M. extorquens AM1 in bioaugmentation experiment including 500 mg/L CeO2 nanoparticles could not promote the nanoparticles accumulation in both natural and surface-sterilized treatments. However, it enh...
Source: Environmental Pollution - April 14, 2024 Category: Environmental Health Authors: Maedeh Soleimanifar Lucia Rodriguez-Freire Source Type: research
Molecules, Vol. 29, Pages 1780: Study on the Design, Synthesis, Bioactivity and Translocation of the Conjugates of Phenazine-1-carboxylic Acid and N-Phenyl Alanine Ester
g Zhu
Junkai Li
The natural pesticide phenazine-1-carboxylic acid (PCA) is known to lack phloem mobility, whereas Metalaxyl is a representative phloem systemic fungicide. In order to endow PCA with phloem mobility and also enhance its antifungal activity, thirty-two phenazine-1-carboxylic acid-N-phenylalanine esters conjugates were designed and synthesized by conjugating PCA with the active structure N-acylalanine methyl ester of Metalaxyl. All target compounds were characterized by 1H NMR, 13C NMR and HRMS. The antifungal evaluation results revealed that several target compounds exhibited moderate to potent antifung...
Source: Molecules - April 14, 2024 Category: Chemistry Authors: Yiran Wu Guoqing Mao Gaoshan Xing Yao Tian Yong Hu Changzhou Liao Li Li Xiang Zhu Junkai Li Tags: Article Source Type: research
Multiple and hereditary renal tumors: a review for radiologists
Radiologia (Engl Ed). 2024 Mar-Apr;66(2):132-154. doi: 10.1016/j.rxeng.2024.03.001. Epub 2024 Mar 23.ABSTRACT80% of renal carcinomas (RC) are diagnosed incidentally by imaging. 2-4% of "sporadic" multifocality and 5-8% of hereditary syndromes are accepted, probably with underestimation. Multifocality, young age, familiar history, syndromic data, and certain histologies lead to suspicion of hereditary syndrome. Each tumor must be studied individually, with a multidisciplinary evaluation of the patient. Nephron-sparing therapeutic strategies and a radioprotective diagnostic approach are recommended. Relevant data for the rad...
Source: Radiologia - April 13, 2024 Category: Radiology Authors: M Á Corral de la Calle J Encinas de la Iglesia G C Fern ández Pérez A Fraino M Repoll és Cobaleda Source Type: research
Endogenous IAA affected fluoranthene accumulation by regulating H < sup > + < /sup > -ATPase and SOD activity in ryegrass
This study explores the role of endogenous indole-3-acetic acid (IAA) in modulating plant responses to pollution stress and its effect on pollutant accumulation, with a focus on fluoranthene (Flu) in ryegrass. To elucidate the mechanism, we employed an IAA promoter (α-aminobutyric acid [α-AB]) and an IAA inhibitor (naphthylphthalamic acid [NPA]) to regulate IAA levels and analyze Flu uptake characteristics. The experimental setup included a Flu treatment group (ryegrass with Flu addition) and a control group (ryegrass without Flu). Our findings demonstrate that Flu treatment enhanced IAA content and plant growth in ryegr...
Source: Ecotoxicology and Environmental Safety - April 13, 2024 Category: Environmental Health Authors: Yuanzhou Xu Yunyun Li Zhuoliang Xiao Xinyue Zhang Jiaguo Jiao Huijuan Zhang Huixin Li Feng Hu Li Xu Source Type: research
Genotype and phenotype in patients with ACAN gene variants: Three cases and literature review
CONCLUSION: Our study achieves a new understanding of the phenotypic spectrum, diagnosis, and management of individuals with ACAN variants. No clear genotype-phenotype relationship of patients with ACAN variants was found. Gene sequencing is necessary to diagnose ACAN variants that cause short stature. In general, appropriate rhGH and/or GnRHa therapy can improve the adult height of affected pediatric patients caused by ACAN variants.PMID:38613222 | PMC:PMC11015147 | DOI:10.1002/mgg3.2439 (Source: Molecular Medicine)
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Wei Tang Ke-Mi Wu Qiong Zhou Yan-Fei Tang Jun-Fen Fu Guan-Ping Dong Chao-Chun Zou Source Type: research
AMPA receptor inhibition alleviates inflammatory response and myocardial apoptosis after myocardial infarction by inhibiting TLR4/NF- κB signaling pathway
This study investigated the role of AMPA receptor inhibition in myocardial infarction and elucidated the underlying mechanisms. This study established a myocardial infarction model by ligating the left anterior descending branch of the coronary artery in Sprague-Dawley rats. The findings suggested that injecting the AMPA receptor antagonist NBQX into myocardial infarction rats effectively alleviated cardiac inflammation, myocardial necrosis, and apoptosis and improved their cardiac contractile function. Conversely, injecting the AMPA receptor agonist CX546 into infarcted rats exacerbated the symptoms and tissue damage, as ...
Source: International Immunopharmacology - April 13, 2024 Category: Allergy & Immunology Authors: Zixuan Li Zhili Yu Shengyu Cui Shan Hu Bin Li Tao Chen Chuan Qu Bo Yang Source Type: research
The role of exogenous hydrogen sulfide in mitigating cadmium toxicity in plants: A comprehensive meta-analysis
Environ Sci Pollut Res Int. 2024 Apr 13. doi: 10.1007/s11356-024-33298-7. Online ahead of print.ABSTRACTReducing the accumulation of cadmium (Cd) and mitigating its toxicity are pivotal strategies for addressing Cd pollution's threats to agriculture and human health. Hydrogen sulfide (H2S) serves as a signaling molecule, playing a crucial role in plant stress defense mechanisms. Nevertheless, a comprehensive assessment of the impact of exogenous H2S on plant growth, antioxidant properties, and gene expression under Cd stress remains lacking. In this meta-analysis, we synthesized 575 observations from 27 articles, revealing...
Source: Environmental Science and Pollution Research International - April 13, 2024 Category: Environmental Health Authors: Hanping Cao Kejin Song Yingying Hu Qingxiao Li Tengfei Ma Rui Li Nan Chen Shunqin Zhu Wanhong Liu Source Type: research
Exogenous methyl jasmonate enhanced kenaf (Hibiscus cannabinus) tolerance against lead (Pb) toxicity by improving antioxidant capacity and osmoregulators
In this study, the effects of exogenous methyl jasmonate (MeJA) on metal uptake and its ability to attenuate metal toxicity in kenaf plants under Pb stress were investigated. The experiment was conducted with five different MeJA concentrations (0, 40, 80, 160, and 320 μM) as a foilar application to kenaf plants exposed to 200 μM Pb stress. The results revealed that pretreatmen of MeJA significantly increased plant dry weight, plant height, and root architecture at all concentrations tested, with the most significant increase at 320 μM. Foliar application of MeJA at 160 μM and 320 μM increased the Pb concentrations in ...
Source: Environmental Science and Pollution Research International - April 13, 2024 Category: Environmental Health Authors: Samavia Mubeen Jiao Pan Wajid Saeed Dengjie Luo Muzammal Rehman Zhang Hui Peng Chen Source Type: research
Genotype and phenotype in patients with ACAN gene variants: Three cases and literature review
CONCLUSION: Our study achieves a new understanding of the phenotypic spectrum, diagnosis, and management of individuals with ACAN variants. No clear genotype-phenotype relationship of patients with ACAN variants was found. Gene sequencing is necessary to diagnose ACAN variants that cause short stature. In general, appropriate rhGH and/or GnRHa therapy can improve the adult height of affected pediatric patients caused by ACAN variants.PMID:38613222 | PMC:PMC11015147 | DOI:10.1002/mgg3.2439 (Source: Molecular Medicine)
Source: Molecular Medicine - April 13, 2024 Category: Molecular Biology Authors: Wei Tang Ke-Mi Wu Qiong Zhou Yan-Fei Tang Jun-Fen Fu Guan-Ping Dong Chao-Chun Zou Source Type: research
Multiple and hereditary renal tumors: a review for radiologists
Radiologia (Engl Ed). 2024 Mar-Apr;66(2):132-154. doi: 10.1016/j.rxeng.2024.03.001. Epub 2024 Mar 23.ABSTRACT80% of renal carcinomas (RC) are diagnosed incidentally by imaging. 2-4% of "sporadic" multifocality and 5-8% of hereditary syndromes are accepted, probably with underestimation. Multifocality, young age, familiar history, syndromic data, and certain histologies lead to suspicion of hereditary syndrome. Each tumor must be studied individually, with a multidisciplinary evaluation of the patient. Nephron-sparing therapeutic strategies and a radioprotective diagnostic approach are recommended. Relevant data for the rad...
Source: Radiologia - April 13, 2024 Category: Radiology Authors: M Á Corral de la Calle J Encinas de la Iglesia G C Fern ández Pérez A Fraino M Repoll és Cobaleda Source Type: research
Endogenous IAA affected fluoranthene accumulation by regulating H < sup > + < /sup > -ATPase and SOD activity in ryegrass
This study explores the role of endogenous indole-3-acetic acid (IAA) in modulating plant responses to pollution stress and its effect on pollutant accumulation, with a focus on fluoranthene (Flu) in ryegrass. To elucidate the mechanism, we employed an IAA promoter (α-aminobutyric acid [α-AB]) and an IAA inhibitor (naphthylphthalamic acid [NPA]) to regulate IAA levels and analyze Flu uptake characteristics. The experimental setup included a Flu treatment group (ryegrass with Flu addition) and a control group (ryegrass without Flu). Our findings demonstrate that Flu treatment enhanced IAA content and plant growth in ryegr...
Source: Ecotoxicology and Environmental Safety - April 13, 2024 Category: Environmental Health Authors: Yuanzhou Xu Yunyun Li Zhuoliang Xiao Xinyue Zhang Jiaguo Jiao Huijuan Zhang Huixin Li Feng Hu Li Xu Source Type: research
