Viruses, Vol. 16, Pages 646: PCV2 Induced Endothelial Derived IL-8 Affects MoDCs Maturation Mainly via NF- & kappa;B Signaling Pathway
Viruses, Vol. 16, Pages 646: PCV2 Induced Endothelial Derived IL-8 Affects MoDCs Maturation Mainly via NF-κB Signaling Pathway
Viruses doi: 10.3390/v16040646
Authors:
Mengyu Zhang
Weicheng Xu
Ning Yang
Zhuowei Li
Shuanghai Zhou
Xuewei Liu
Jianfang Wang
Huanrong Li
Porcine circovirus type 2 (PCV2) infection can cause immunosuppressive diseases in pigs. Vascular endothelial cells (VECs), as the target cells for PCV2, play an important role in the immune response and inflammatory regulation. Endothelial IL-8, which is produced by porcine hip artery endothelial cells (PIECs) infected with PCV2, ...
Source: Viruses - April 22, 2024 Category: Virology Authors: Mengyu Zhang Weicheng Xu Ning Yang Zhuowei Li Shuanghai Zhou Xuewei Liu Jianfang Wang Huanrong Li Tags: Article Source Type: research
EGCG suppresses PD-1 expression of T cells via inhibiting NF- κB phosphorylation and nuclear translocation
Int Immunopharmacol. 2024 Apr 20;133:112069. doi: 10.1016/j.intimp.2024.112069. Online ahead of print.ABSTRACTEpigallocatechin-3-gallate (EGCG) is an important tea polyphenol with anti-tumor potential. Our previous studies revealed that EGCG was a promising immune checkpoint inhibitor (ICI) as it could downregulate expression of programmed cell death 1 ligand 1 (PD-L1) in tumor cells, thereby resulting tumor killing effect. In particular, EGCG can effectively avoid the inflammatory storm caused by anti-tumor therapy, which is a healthy green capacity absent from many ICIs. However, the relationship between EGCG and program...
Source: International Immunopharmacology - April 21, 2024 Category: Allergy & Immunology Authors: Zhong-Da Li Fangfang Liu Yanqiao Zeng Yingnan Liu Wenhe Luo Feng Yuan Su Li Qi Li Jiaxin Chen Mayumi Fujita Guofang Zhang Yang Li Source Type: research
Translocation and confinement of tetraamines in adaptable microporous cavities
In this study, we propose an alternative mechanism that does not rely on the use of neutral metal vacancies as binding sites but is enabled by the structural adaptability of heterobimetallic Ti2Ca2 clusters. The combination of hard (Ti+4) and soft (Ca2+) metal centers in the inorganic nodes of the framework enables MUV-10 to adapt its pore windows to the presence of triethylenetetramine molecules. This dynamic cluster response facilitates the translocation and binding of tetraamine inside the microporous cavities to enable the formation of bis-coordinate adducts that are stable in water. The extension of this grafting conc...
Source: Angewandte Chemie - April 21, 2024 Category: Chemistry Authors: Ana Rubio-Gaspar Alechania Misturini Reisel Mill án Neyvis Almora-Barrios Sergio Tatay Volodymyr Bon Mickaele Bonneau Vincent Guillerm Mohamed Eddaoudi Sergio Naval ón Stefan Kaskel Donatella Armentano Carlos Marti-Gastaldo Source Type: research
Moringin, an isothiocyanate modulates multiple cellular signalling molecules in breast cancer cells
Cell Signal. 2024 Apr 19:111181. doi: 10.1016/j.cellsig.2024.111181. Online ahead of print.ABSTRACTProhibitin (PHB) is a pleiotropic molecule with a variety of known functions and subcellular locations. PHB's function in breast cancer is poorly understood. Herein, we report that PHB is expressed in cancer types of diverse origin including breast cancer. The cancer patients with changes in PHB were reported to have significantly reduced 'overall survival' in comparison to the cases without alterations in PHB. The expression of PHB was increased by H2O2 and also by Moringin (MG), which is an isothiocyanate derived from the s...
Source: Cellular Signalling - April 21, 2024 Category: Cytology Authors: Ankit Srivastava Shruti Mishra None Avadhesh Anusmita Shekher Vipin Rai Anupam Dhasmana Jayanta Das Daniele Perenzoni Renato Iori Subash C Gupta Source Type: research
Inhibition of YAP/TAZ pathway contributes to the cytotoxicity of silibinin in MCF-7 and MDA-MB-231 human breast cancer cells
Cell Signal. 2024 Apr 19:111186. doi: 10.1016/j.cellsig.2024.111186. Online ahead of print.ABSTRACTBreast cancer is one of the most common cancers threatening women's health. Our previous study found that silibinin induced the death of MCF-7 and MDA-MB-231 human breast cancer cells. We noticed that silibinin-induced cell damage was accompanied by morphological changes, including the increased cell aspect ratio (cell length/width) and decreased cell area. Besides, the cytoskeleton is also destroyed in cells treated with silibinin. YAP/TAZ, a mechanical signal sensor interacted with extracellular pressure, cell adhesion area...
Source: Cellular Signalling - April 21, 2024 Category: Cytology Authors: Jianing Fu Weiwei Liu Siyu Liu Ruxiao Zhao Toshihiko Hayashi Haina Zhao Yinlanqi Xiang Kazunori Mizuno Shunji Hattori Hitomi Fujisaki Takashi Ikejima Source Type: research
GSE231534 Tet Controls Axon Guidance in Early Brain Development through Glutamatergic Signaling
Contributors : Hiep Tran ; Le Le ; Badri Nath Singh ; Joseph Kramer ; Ruth StewardSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterTen-eleven translocation (Tet) is an important gene in neurodevelopment, but how Tet regulates brain development is still under study. Mutations in human TET proteins have been found in individuals with neurodevelopmental disorders. Here we report a new function of Tet in regulating Drosophila early brain development. We found that mutation on the Tet DNA-binding domain (TetAXXC) resulted in axon guidance defects in the mushroom body (MB). T...
Source: GEO: Gene Expression Omnibus - April 20, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Drosophila melanogaster Source Type: research
High glucose-induced p66Shc mitochondrial translocation regulates autophagy initiation and autophagosome formation in syncytiotrophoblast and extravillous trophoblast
p66Shc, as a redox enzyme, regulates reactive oxygen species (ROS) production in mitochondria and autophagy. However, the mechanisms by which p66Shc affects autophagosome formation are not fully understood. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 20, 2024 Category: Molecular Biology Authors: Lulu Ji, Xiaoli Zhang, Zhiguo Chen, Yuexiao Wang, Hengxuan Zhu, Yaru Nai, Yanyi Huang, Rujie Lai, Yu Zhong, Xiting Yang, Qiongtao Wang, Hanyang Hu and Lin Wang Tags: Research Source Type: research
Evidence for persistent UV-induced DNA damage and altered DNA damage response in xeroderma pigmentosa patient corneas
Exp Eye Res. 2024 Apr 17:109901. doi: 10.1016/j.exer.2024.109901. Online ahead of print.ABSTRACTXeroderma pigmentosum (XP) is a rare genetic disorder characterized by injury to the ocular surface due to exposure to ultraviolet (UV) radiation. UV-induced damage in the cells leads to the formation of cyclobutane pyrimidine dimers (CPDs) and 6-4 pyrimidine-pyrimidone photoproducts that are repaired by the NER (Nucleotide Excision Repair) pathway. Mutations in the genes coding for NER proteins, as reported in XP patients, would lead to sub-optimal damage repair resulting in clinical signs varying from photo-keratitis to cancer...
Source: Experimental Eye Research - April 19, 2024 Category: Opthalmology Authors: Jacquelyn Akepogu Saumya Jakati Sunita Chaurasia Charanya Ramachandran Source Type: research
Insights into the alleviation of cadmium toxicity in rice by nano-zinc and Serendipita indica: Modulation of stress-responsive gene expression and antioxidant defense system activation
Environ Pollut. 2024 Apr 17:123952. doi: 10.1016/j.envpol.2024.123952. Online ahead of print.ABSTRACTThe adversities of cadmium (Cd) contamination are quite distinguished among other heavy metals (HMs), and so is the efficacy of zinc (Zn) nutrition in mitigating Cd toxicity. Rice (Oryza sativa) crop, known for its ability to absorb HMs, inadvertently facilitates the bioaccumulation of Cd, posing a significant risk to both the plant itself and to humans consuming its edible parts, and damaging the environment as well. The use of nanoparticles, such as nano-zinc oxide (nZnO), to improve the nutritional quality of crops and t...
Source: Environmental Pollution - April 19, 2024 Category: Environmental Health Authors: Muhammad Faheem Adil Shafaque Sehar Zhengxin Ma Khajista Tahira Syed Muhammad Hassan Askri Mohamed A El-Sheikh Aqeel Ahmad Fanrui Zhou Ping Zhao Imran Haider Shamsi Source Type: research
GSE263911 AML1-ETO and CCND2 overexpression ¬ cooperate to drive acute myeloid leukemia initiation and progression
In conclusion, we confirmed that introduction of the CCND2 gene into the AML/ETO pre-leukemia mice can trigger the development of leukemia. We also confirmed that CCND2 overexpression resulted in the upregulation of the mTOR pathway and inhibiting the pathway may be a therapeutic agent for this subtype of leukemia. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus Source Type: research
GSE255251 Integrative transcriptomic and proteomic profiling of subconfluent and confluent cancer cells
In this study we examine the impact of cell confluency on gene expression. We focused on Argonaute (AGO) protein dynamics and associated gene and protein expression in HEK293, A375, and SHSY5Y cell lines. As a measure of cell confluency, we observed a profound translocation of AGO2 into the nucleus. Therefore, we generated transcriptomic data using RNA sequencing to compare gene expression in subconfluent versus confluent cells, which highlighted significant alterations in gene regulation patterns directly corresponding to changes in cell density. Our study also encompasses miRNA profiling data obtained through small RNA s...
Source: GEO: Gene Expression Omnibus - April 19, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Other Homo sapiens Source Type: research
Impact of MG132 induced-proteotoxic stress on αB-crystallin and desmin phosphorylation and O-GlcNAcylation and their partition towards cytoskeleton
Biochimie. 2024 Apr 16:S0300-9084(24)00079-8. doi: 10.1016/j.biochi.2024.04.004. Online ahead of print.ABSTRACTSmall Heat Shock Proteins are considered as the first line of defense when proteostasis fails. Among them, αB-crystallin is expressed in striated muscles in which it interacts with desmin intermediate filaments to stabilize them, maintaining cytoskeleton's integrity and muscular functionalities. Desmin is a key actor for muscle health; its targeting by αB-crystallin is thus crucial, especially in stress conditions. αB-crystallin is phosphorylated and O-GlcNAcylated. Its phosphorylation increases consecutively t...
Source: Biochimie - April 18, 2024 Category: Biochemistry Authors: Nathan Bulangalire Charlotte Claeyssen Onnik Agbulut Caroline Cieniewski-Bernard Source Type: research
miR-30a-5p mediates ferroptosis of hippocampal neurons in chronic cerebral hypoperfusion-induced cognitive dysfunction by modulating the SIRT1/NRF2 pathway
CONCLUSION: miR-30a-5p induces hippocampal neuronal ferroptosis and exacerbates post-CCH cognitive dysfunction by targeting SIRT1 and reducing NRF2 nuclear translocation.PMID:38636610 | DOI:10.1016/j.brainresbull.2024.110953 (Source: Cell Research)
Source: Cell Research - April 18, 2024 Category: Cytology Authors: Lihua Wang Mingjie Li Bing Liu Ruihan Zheng Xinyi Zhang Shuoyi Yu Source Type: research
Ivermectin ameliorates acute myocarditis via the inhibition of importin-mediated nuclear translocation of NF- κB/p65
CONCLUSIONS: Ivermectin inhibits the nuclear translocation of NF-κB/p65 and the expression of major pro-inflammatory cytokines in myocarditis. The therapeutic effects of IVM on viral and non-viral myocarditis models suggest its potential application in the treatment of acute myocarditis.PMID:38636372 | DOI:10.1016/j.intimp.2024.112073 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 18, 2024 Category: Allergy & Immunology Authors: Xu Gao Yunling Xuan Zhou Zhou Chen Chen Dao Wen Wang Zheng Wen Source Type: research
miR-30a-5p mediates ferroptosis of hippocampal neurons in chronic cerebral hypoperfusion-induced cognitive dysfunction by modulating the SIRT1/NRF2 pathway
CONCLUSION: miR-30a-5p induces hippocampal neuronal ferroptosis and exacerbates post-CCH cognitive dysfunction by targeting SIRT1 and reducing NRF2 nuclear translocation.PMID:38636610 | DOI:10.1016/j.brainresbull.2024.110953 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - April 18, 2024 Category: Neurology Authors: Lihua Wang Mingjie Li Bing Liu Ruihan Zheng Xinyi Zhang Shuoyi Yu Source Type: research
