Pharmacological modulation of Na+, K+-ATPase as a potential target for OXA-induced neurotoxicity: correlation between anxiety and cognitive decline and beneficial effects of 7-chloro-4-(phenylselanyl) quinoline.
Abstract Growing evidence demonstrates that Oxaliplatin (OXA) is commonly associated with neurotoxicity that leads to emotional and cognitive impairments. The aim of the present study was to evaluate the OXA and Na+, K+-ATPase interaction and to correlate anxious behavior and cognitive impairment induced by this chemotherapeutic in Swiss mice. Also, considering the pharmacological modulation of Na+, K+-ATPase as a potential target for OXA-induced neurotoxicity, the therapeutic potential of 7-chloro-4-(phenylselanyl) quinoline (4-PSQ) was evaluated. Mice received OXA (10 mg kg-1) or vehicle by intrape...
Source: Brain Research Bulletin - July 3, 2020 Category: Neurology Authors: Reis AS, Paltian JJ, Domingues WB, Costa GP, Alves D, Giongo JL, Campos VF, Luchese C, Wilhelm EA Tags: Brain Res Bull Source Type: research

RAGE signaling pathway in Hippocampus Dentate Gyrus Involved in GLT-1 decrease Induced by Chronic Unpredictable Stress in Rats.
Abstract A pivotal role of glutamatergic neurotransmission in the pathophysiology of major depressive disorder (MDD) has been supported in preclinical and clinical studies. Glutamate transporters are responsible for rapid uptake of glutamate to maintain glutamate homeostasis. Downregulation of glutamate transporters has been reported in MDD patients and animal models. However, the mechanism for stress-induced modulation of glutamate transporter expression is poorly understood. Receptor for advanced glycosylation end products (RAGE), a member of immunoglobulin family, is found expressed widely in brain and play imp...
Source: Brain Research Bulletin - July 1, 2020 Category: Neurology Authors: Yang F, Wang H, Chen H, Ran D, Tang Q, Wong P, Sun Y, Jiang W Tags: Brain Res Bull Source Type: research

Restriction and hyperlipidic diets during pregnancy, lactation and adult life modified the expression of dopaminergic system related genes both in female mice and their adult offspring.
Abstract The neurocircuitry underlying hunger, satiety, motivation to eat and food reward is complex, however a lot of mechanisms are still unknown. Two main cerebral areas are responsible for controlling feeding through hunger and food reward: the hypothalamus (HPT) and the ventral tegmental area (VTA), respectively. The dopaminergic system modulates both these areas and is essential to control food ingestion. Therefore, we aim to evaluate the effects of restrictive and hyperlipidic diets during pregnancy, lactation and during adult life of the offspring, on the expression of dopaminergic system genes in VTA and ...
Source: Brain Research Bulletin - June 30, 2020 Category: Neurology Authors: Feistauer V, Fisch J, da Silva Oliveira CK, Giovenardi M, Almeida S Tags: Brain Res Bull Source Type: research

Alpha Frequency rTMS Modulates Theta Lagged Nonlinear Connectivity in Dorsal Attention Network.
This study is an investigation of the behavioral and network effects of alpha and theta repetitive transcranial magnetic stimulation (rTMS) over RDLPFC. 20 healthy participants were randomly assigned to two groups of theta (n = 11, f = 10 Hz) and alpha (n = 9, f = 6 Hz) rTMS. Electroencephalogram (EEG) was recorded before and after each session while resting and performing tasks. Current source density (CSD) and functional connectivity (FC) in DAN and default mode network (DMN) and their correlations with rapid visual information processing task (RVIP) s...
Source: Brain Research Bulletin - June 30, 2020 Category: Neurology Authors: Kazemi R, Rostami R, Dehghan S, Nasiri Z, Lotfollahzadeh S, Hadipour AL, Khomami S, Ishii R, Ikeda S Tags: Brain Res Bull Source Type: research

Modulatory role of hippocampal dopamine receptors in antinociceptive responses induced by chemical stimulation of the lateral hypothalamus in an animal model of persistent inflammatory pain.
This study evaluated the pain modulatory role of intra-CA1 dopamine receptors in LH chemical stimulation-induced antinociception in the formalin test (persistent inflammatory pain model). Vehicle control groups received saline or DMSO into the CA1 and saline into the LH. Carbachol control groups received carbachol (250 nM) into the LH 5 min after saline or DMSO injections into the CA1. In the treatment groups, intra-CA1 administration of SCH-23390 or Sulpiride (D1- or D2-like dopamine receptor antagonists, respectively) was performed 5 min before carbachol injection. Formalin tests were done in all rat...
Source: Brain Research Bulletin - June 29, 2020 Category: Neurology Authors: Zakeri M, Soltanizadeh S, Karimi-Haghighi S, Haghparast A Tags: Brain Res Bull Source Type: research

T-Distribution Stochastic Neighbor Embedding for Fine Brain Functional Parcellation on rs-fMRI.
Abstract In human functional connectome and network analyses, brain subregions that are functionally parcellated have a better consistency than do anatomical subregions. Resting-state functional magnetic resonance imaging (rs-fMRI) signals can function as coherent connectivity patterns that can be used to assess human brain functional architecture. In this paper, an optimized framework that combines automatic spectral clustering with dimensionality reduction is presented for fine-grained functional parcellation of rs-fMRI of the human brain. First, the t-distribution stochastic neighborhood embedding (t-SNE) algor...
Source: Brain Research Bulletin - June 27, 2020 Category: Neurology Authors: Hu Y, Li X, Wang L, Han B, Nie S Tags: Brain Res Bull Source Type: research

Theta burst stimulation ameliorates symptoms of experimental autoimmune encephalomyelitis and attenuates reactive gliosis.
Abstract Multiple sclerosis (MS) is a chronic neurodegenerative disease caused by inflammatory processes in the central nervous system (CNS). Decades of research led to discovery of several disease-modifying therapeutics strategies with moderate success. Experimental autoimmune encephalomyelitis (EAE) is currently the most commonly used experimental model for MS and for studying various therapeutic approaches. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neurostimulation technique with multiple beneficial effects on healthy as well as CNS with pathology. However, the molecular and cellular...
Source: Brain Research Bulletin - June 26, 2020 Category: Neurology Authors: Dragic M, Zeljkovic M, Stevanovic I, Ilic T, Ilic N, Nedeljkovic N, Ninkovic M Tags: Brain Res Bull Source Type: research

Effects of nitrous oxide on glycinergic transmission in rat spinal neurons.
Abstract We investigated the effects of nitrous oxide (N2O) on glycinergic inhibitory whole-cell and synaptic responses using a "synapse bouton preparation," dissociated mechanically from rat spinal sacral dorsal commissural nucleus (SDCN) neurons. This technique can evaluate pure single- or multi-synaptic responses from native functional nerve endings and enable us to accurately quantify how N2O influences pre- and postsynaptic transmission. We found that 70% N2O enhanced exogenous glycine-induced whole-cell currents (IGly) at glycine concentrations lower than 3 × 10-5 M, but did not...
Source: Brain Research Bulletin - June 26, 2020 Category: Neurology Authors: Nakamura M, Jang IS, Yamaga T, Kotani N, Akaike N Tags: Brain Res Bull Source Type: research

Inhibition of mTORC1 improves STZ-induced AD-like impairments in mice.
Abstract Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) share some pathological features, including tau hyperphosphorylation and deficits in insulin signaling, but the underlying mechanism and effective drugs for treating AD are unknown. The AD-like brain impairments are almost same in both of mouse type 2 DM models induced by the multiple low-dose intraperitoneal (i.p.) streptozotocin (STZ) injection and twice intracerebroventricular (i.c.v.) STZ injection. We found that memory disorders, impairment of insulin signaling, and AD-like tauopathies were exhibited in two different STZ-induced mouse model...
Source: Brain Research Bulletin - June 26, 2020 Category: Neurology Authors: Cao Y, Liu B, Xu W, Wang L, Shi F, Li N, Lei Y, Wang J, Tian Q, Zhou X Tags: Brain Res Bull Source Type: research

Treatment of electrical wrist stimulation reduces chemotherapy-induced neuropathy and ultrasound vocalization via modulation of spinal NR2B phosphorylation.
This study was undertaken to investigate the analgesic effects of electrical stimulation on docetaxel-induced neuropathic pain in mice and to identify associated changes in ultrasound vocalizations. Peripheral neuropathy was induced with intraperitoneally injected docetaxel (5 mg/kg) on 3 times every 2 days in male ICR mice. Electrical wrist stimulation was administered and pain behavior signs were evaluated by von Frey filaments and thermal stimulation on the hind paw. Ultrasound vocalizations were measured using ultrasound microphones, after electrical stimulation. After mice developed docetaxel-induced neuropathi...
Source: Brain Research Bulletin - June 25, 2020 Category: Neurology Authors: Kang SY, Bang SK, Kwon OS, Seo SY, Choi KH, Cho SJ, Yoo HS, Lee JS, Kim HW, Ryu Y Tags: Brain Res Bull Source Type: research

Epimedium flavonoids protect neurons and synapses in the brain via activating NRG1/ErbB4 and BDNF/Fyn signaling pathways in a chronic cerebral hypoperfusion rat model.
Abstract Cerebral hypoperfusion is a common feature of cerebral small vascular disease (CSVD), which has been considered as one of the causes of cognitive decline in recent years. Epimedium flavonoids (EF) are the main ingredients extracted from Epimedium. The purpose of this study was to investigate the effects of EF on cognitive impairment, and the underlying mechanisms in rats with permanent occlusion of the bilateral common carotid artery (2VO). EF (50, 100, and 200 mg/kg) was intragastrically administered for 12 weeks starting 2 weeks after 2VO surgery. The results showed that EF treatment improved lea...
Source: Brain Research Bulletin - June 24, 2020 Category: Neurology Authors: Niu HM, Ma DL, Wang MY, Chen XP, Zhang L, Li YL, Zhang L, Li L Tags: Brain Res Bull Source Type: research

Overexpression of HDAC6, but not HDAC3 and HDAC4 in the penumbra after photothrombotic stroke in the rat cerebral cortex and the neuroprotective effects of α-phenyl tropolone, HPOB, and sodium valproate.
Overexpression of HDAC6, but not HDAC3 and HDAC4 in the penumbra after photothrombotic stroke in the rat cerebral cortex and the neuroprotective effects of α-phenyl tropolone, HPOB, and sodium valproate. Brain Res Bull. 2020 Jun 24;: Authors: Demyanenko SV, Dzreyan VA, Uzdensky AB Abstract Epigenetic processes play important roles in brain responses to ischemic injury. We studied effects of photothrombotic stroke (PTS, a model of ischemic stroke) on the intracellular level and cellular localization of histone deacetylases HDAC3, HDAC4 and HDAC6 in the rat brain cortex, and tested the potential n...
Source: Brain Research Bulletin - June 24, 2020 Category: Neurology Authors: Demyanenko SV, Dzreyan VA, Uzdensky AB Tags: Brain Res Bull Source Type: research

Sex-dependent effects of chronic fluoxetine exposure during adolescence on passive avoidance memory, nociception, and prefrontal brain-derived neurotrophic factor mRNA expression.
In conclusion, chronic fluoxetine treatment has sex-dependent effects on passive avoidance memory and BDNF mRNA expression, but the pain threshold decreases in both sexes. Therefore, passive avoidance memory, pain sensitivity, and the BDNF level are influenced by the manipulation of the serotonergic system. PMID: 32585291 [PubMed - as supplied by publisher] (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - June 22, 2020 Category: Neurology Authors: Sakhaie N, Sadegzadeh F, Dehghany R, Adak O, Hakimeh S Tags: Brain Res Bull Source Type: research

MiR-410-3p overexpression ameliorates neurological deficits in rats with hypoxic-ischemic brain damage.
Abstract Neonatal hypoxic-ischemic encephalopathy (HIE) is major cause of neonatal death or long-term neurodevelopmental disabilities, which becomes a major practical problem currently in clinic. Whereas, its pathophysiology and underlying molecular mechanism is not clear. MicroRNAs are involved in the normal growth and development of neuronal cells. Herein, the objective of this research was to examine the roles of miR-410-3p in neurological deficits, neuronal injury and neuron apoptosis after hypoxic-ischemic and to explore its associated mechanisms. We established the hypoxic-ischemic brain damage (HIBD) model ...
Source: Brain Research Bulletin - June 21, 2020 Category: Neurology Authors: Xiao QX, Wen S, Zhang XR, Xue LL, Zhang ZB, Tan YX, Du RL, Zhu ZQ, Zhu YH, Wang TH, Yu CY, Xiong LL Tags: Brain Res Bull Source Type: research

HLY78 protects blood-brain barrier integrity through Wnt/ β-catenin signaling pathway following subarachnoid hemorrhage in rats.
In conclusion, HLY78 could preserve BBB integrity, possibly through the Wnt/β-catenin signaling pathway. HLY78 might be a potential treatment option to protect BBB integrity following SAH. PMID: 32565130 [PubMed - as supplied by publisher] (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - June 18, 2020 Category: Neurology Authors: Luo X, Li L, Zheng W, Gu L, Zhang X, Li Y, Xie Z, Cheng Y Tags: Brain Res Bull Source Type: research

Lowly expressed lncRNA PVT1 suppresses proliferation and advances apoptosis of glioma cells through up-regulating microRNA-128-1-5p and inhibiting PTBP1.
CONCLUSION: This study suggests that down-regulated PVT1 or up-regulated miR-128-1-5p boosts apoptosis and attenuates proliferation of glioma cells by inhibiting PTBP1 expression. This study is essential for finding new therapeutic targets for glioma. PMID: 32562719 [PubMed - as supplied by publisher] (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - June 17, 2020 Category: Neurology Authors: Dahai Z, Daliang C, Famu L, Xiang W, Lenian L, Jianmin C, Xiaobing X Tags: Brain Res Bull Source Type: research

Coexpression of VGLUT1 and VGLUT2 in precerebellar neurons in the lateral reticular nucleus of the rat.
Abstract Vesicular glutamate transporter (VGLUT) 1 and VGLUT2 have been reported to distribute complementally in most brain regions and have been assumed to define distinct functional elements. Previous studies have shown the expression of VGLUT1 mRNA and VGLUT2 mRNA in the lateral reticular nucleus (LRN), a key precerebellar nucleus sending mossy fibers to the cerebellum. In the present study, we firstly examined the coexpression of VGLUT1 and VGLUT2 mRNA in the LRN of the rat by dual-fluorescence in situ hybridization. About 81.89% of glutamatergic LRN neurons coexpressed VGLUT1 and VGLUT2 mRNA, and the others e...
Source: Brain Research Bulletin - June 17, 2020 Category: Neurology Authors: Li ZH, Zhang CK, Qiao Y, Ge SN, Zhang T, Li JL Tags: Brain Res Bull Source Type: research

Methamphetamine induces GSDME-dependent cell death in hippocampal neuronal cells through the endoplasmic reticulum stress pathway.
Abstract Methamphetamine (METH) is an illegal amphetamine-typed psychostimulant that is abused worldwide and causes serious public health problems. METH exposure induces apoptosis and autophagy in neuronal cells. However, the role of pyroptosis in METH-induced neurotoxicity is still unclear. Here, we investigate whether pyroptosis is involved in METH-induced hippocampal neurotoxicity and the potential mechanisms of Endoplasmic reticulum (ER) stress in hippocampal neuronal cells. For this purpose, the expression levels of pyroptosis-related proteins, GSDMD and GSDME, were analyzed by immunoblotting and immunohistoc...
Source: Brain Research Bulletin - June 13, 2020 Category: Neurology Authors: Liu Y, Wen D, Gao J, Xie B, Yu H, Shen Q, Zhang J, Jing W, Cong B, Ma C Tags: Brain Res Bull Source Type: research

Inhibition of NK1R attenuates LPS-induced microglial inflammation and consequent death of PC12 cells.
Abstract Microglia, the resident immune cells in the central nervous system, play a critical role under physiological conditions, but they may be activated and exaggerate the pathological development of Parkinson's disease (PD). Recent reports have suggested that neurokinin 1 receptor (NK1R) is involved in various inflammatory diseases, including PD. However, whether neurokinin 1 (NK1) is involved in the activation of microglial cells remains unclear. In the present study, we found that (1) NK1R is located in microglial cells and upregulated in lipopolysaccharide (LPS)-activated BV2 microglia. Application of CP-99...
Source: Brain Research Bulletin - June 12, 2020 Category: Neurology Authors: Jiang W, Wang X, Wang W, Hua F, Zhang Z, Zhang Z, Xiang J, Yang X Tags: Brain Res Bull Source Type: research

The L1 cell adhesion molecule affects protein kinase D1 activity in the cerebral cortex in a mouse model of Alzheimer's disease.
Abstract Alzheimer's disease (AD) is characterized by deposition of β-amyloid protein (Aβ), neurofibrillary tangles and cognitive deficits resulting from neuronal cell death. In search for the molecular underpinnings of the disease, we were interested in the relationship between Aβ, L1 cell adhesion molecule and protein kinase D1 (PKD1), which are not only implicated in neural development and functional maintenance in the adult, but are also neuroprotective under pathological conditions. Based on our observations that L1 and phosphorylated, i.e. activated, protein kinase PKD1 (pPKD1) co-localizes in...
Source: Brain Research Bulletin - June 12, 2020 Category: Neurology Authors: Chen S, Jiang Q, Huang P, Hu C, Shen H, Schachner M, Zhao W Tags: Brain Res Bull Source Type: research

Effects of locus coeruleus activation and inactivation on hippocampal formation theta rhythm in anesthetized rats.
Abstract Previously obtained data suggests that noradrenaline (NE) released from the efferent locus coeruleus (LC) endings in hippocampal formation (HPC) may serve as an important modulating signal involved in the pharmacological mechanisms responsible for the production of type 2 theta rhythm in rats. Hence, two distinct hypotheses were tested in the present study: 1/ if the decrease in HPC level of NE is correlated with the desynchronization of HPC field potential, then the inhibition of LC would be expected to abolish HPC type 2 theta rhythm; 2/ if the increase in HPC NE level is correlated with synchronization...
Source: Brain Research Bulletin - June 12, 2020 Category: Neurology Authors: Broncel A, Bocian R, Kłos-Wojtczak P, Konopacki J Tags: Brain Res Bull Source Type: research

Resting state signal latency assesses the propagation of intrinsic activations and estimates anti-epileptic effect of Levetiracetam in Rolandic Epilepsy.
CONCLUSION: Our RSLA analysis indicated an association between centro-temporal spikes and earlier hemodynamic activations in epileptogenic regions in Rolandic epilepsy, which were counteracted by LEV treatment. As it allows for the mapping of propagation features of intrinsic activity and drug-effects, our findings suggest potential of lag based analyses in detecting focus localization and estimating treatment effects. PMID: 32535220 [PubMed - as supplied by publisher] (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - June 11, 2020 Category: Neurology Authors: Xu Q, Hu Z, Yang F, Bernhardt BC, Zhang Q, Stufflebeam SM, Zhang Z, Lu G Tags: Brain Res Bull Source Type: research

Gut microbiota modulates stress-induced hypertension through the HPA axis.
Abstract Stress is associated with an increased risk of hypertension, and the incidence of stress-related hypertension has risen rapidly in recent years; however, the underlying mechanisms remain elusive. Gut dysbiosis has been demonstrated to contribute to hypertension and hyperactivation of the hypothalamus-pituitary-adrenal (HPA) axis. Based on our previous findings showing the altered gut microbiota in the rats of stress-induced hypertension (SIH), the present study aims to investigate whether the stress-induced alteration in gut microbiota can lead to the dysfunction of the HPA axis which contributes to the d...
Source: Brain Research Bulletin - June 11, 2020 Category: Neurology Authors: Wu Q, Xu Z, Song S, Zhang H, Zhang W, Liu L, Chen Y, Sun J Tags: Brain Res Bull Source Type: research

Hippocampal mRNA expression profiling in mice exposed to chronic unpredictable mild stress.
Abstract Depression is a state of low mood and aversion to activity, affecting a person's thoughts, behavior, motivation, feelings and sense of well-being, which is associated with dramatical gene expression changes in hippocampus. Rodents induced by chronic unpredictable mild stress (CUMS) demonstrate typical depression-like behaviors similar to clinical patients, therefore, are commonly used as a model for depression and antidepressant study. In order to enhance our understanding of the molecular mechanisms of the pathogenesis of depression, in the present study, the hippocampal mRNA expression profile of mice e...
Source: Brain Research Bulletin - June 10, 2020 Category: Neurology Authors: Tao Y, Xie Z, Shi J, Ou R, Wu H, Shi H, Huang F, Wu X Tags: Brain Res Bull Source Type: research

An early increase in glutamate is critical for the development of depression-like behavior in a chronic restraint stress (CRS) model.
In conclusion, an initial increase in glutamate levels plays an important role in the development of depression-like behavior in the CRS model. PMID: 32505508 [PubMed - as supplied by publisher] (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - June 4, 2020 Category: Neurology Authors: Li J, Sha L, Xu Q Tags: Brain Res Bull Source Type: research

Endurance training exerts time-dependent modulation on depressive responses and circadian rhythms of corticosterone and BDNF in the rats with pinealectomy.
Abstract Pinealectomy can cause a disturbance in emotional status and circadian rhythms of the endocrine and metabolic functions in the body. Endurance training is considered a part of the complex therapy of dysfunctions driven by changes in circadian dynamics of many physiological indicators. In the present study, we aimed to study the effect of endurance training on depressive behavior induced by pinealectomy in rat. We tested the hypothesis that endurance training can have a beneficial impact on depressive behavior induced by pinealectomy in rat via correction of desynchronized circadian rhythms of corticostero...
Source: Brain Research Bulletin - June 4, 2020 Category: Neurology Authors: Tchekalarova J, Atanasova M, Ivanova N, Boyadjiev N, Mitreva R, Georgieva K Tags: Brain Res Bull Source Type: research

Curcumin alleviates neuroinflammation, enhances hippocampal neurogenesis, and improves spatial memory after traumatic brain injury.
Abstract Cognitive decline is one of the most obvious symptoms of traumatic brain injury (TBI). Previous studies have demonstrated that cognitive decline is related to substantially increased neuroinflammation and decreased neurogenesis in the hippocampus in a rat model of TBI. Using this model, we explored the role of curcumin (Cur) in ameliorating TBI-impaired spatial memory because Cur has been shown to exhibit anti-chronic-neuroinflammatory, neurogenesis-promoting, and memory-improving properties. Animals received daily Cur or vehicle treatment for 28 days after TBI and also received 50-bromodeoxyuridine(BrdU)...
Source: Brain Research Bulletin - June 2, 2020 Category: Neurology Authors: Sun G, Zhao P, Fan L, Bao Z, Tu Y, Li C, Chao H, Xu X, Ji J Tags: Brain Res Bull Source Type: research

Association of increase in Serping1 level with dopaminergic cell reduction in an MPTP-induced Parkinson's disease mouse model.
Abstract Parkinson's disease (PD) is a progressive neurodegenerative disease, which shows distinct manifestations such as significant loss of dopaminergic neurons in the substantia nigra (SN). Gene expression was analyzed in the SN of mice treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), wherein downregulation of dopaminergic neurons occurred to examine the possible causes leading to the loss of dopaminergic neurons. In addition, a serine/cysteine protease inhibitor (Serping1) was studied as one of the genes that were prominently upregulated in mice chronically intoxicated with MPTP. Western blot ...
Source: Brain Research Bulletin - May 30, 2020 Category: Neurology Authors: Seo MH, Yeo S Tags: Brain Res Bull Source Type: research

Expression and functional characterization of transient receptor potential vanilloid 4 in the dorsal root ganglion and spinal cord of diabetic rats with mechanical allodynia.
Abstract Diabetic mechanical allodynia (DMA) is a common manifestation in patients with diabetes mellitus, and currently, no effective treatment is available. Transient receptor potential vanilloid 4 (TRPV4) is involved in mechanical hypersensitivity resulting from varying aetiologies in animal, but its expression pattern during DMA and whether it contributes to this condition are still unclear. We investigated the spatial and temporal expression patterns of TRPV4 in the dorsal root ganglion (DRG) and spinal dorsal horn (SDH) by qRT-PCR, Western blotting and immunofluorescence assays. The pathophysiological role o...
Source: Brain Research Bulletin - May 29, 2020 Category: Neurology Authors: Cui YY, Li MY, Li YT, Ning JY, Gou XC, Shi J, Li YQ Tags: Brain Res Bull Source Type: research

Tacrine accelerates spatial long-term memory via improving impaired neural oscillations and modulating GAD isomers including neuro-receptors in the hippocampus of APP/PS1 AD mice.
In this study, we did verify that tacrine induced recovery of the specific pattern associated memory along with long-term memory through the improvement in the pattern of neural oscillation from deficits condition in the hippocampus of 6th month old AD mice. Our results showed that tacrine improved the performance of Morris water maze related spatial cognitive functions, and enhanced LTP in AD-TAC mice. Furthermore, our results implied that tacrine strongly improve the patterns of neural oscillations, and hippocampal synaptic plasticity in the 6th month old APP-PS1 double transgenic AD-TAC mice via changing the theta and a...
Source: Brain Research Bulletin - May 27, 2020 Category: Neurology Authors: Kumari E, Li K, Yang Z, Zhang T Tags: Brain Res Bull Source Type: research

The selenocompound 1-methyl-3-(phenylselanyl)-1H-indole attenuates depression-like behavior, oxidative stress, and neuroinflammation in streptozotocin-treated mice.
ago L Abstract Major depressive disorder (MDD) is a chronic mental illness affecting a wide range of people worldwide. The pathophysiology of MDD is not completely elucidated, but it is believed that oxidative stress and neuroinflammation are involved. In light with this, the aim of the present study was to investigate whether a single administration of the antioxidant 1-methyl-3-(phenylselanyl)-1H-indole (MFSeI) was able to reverse the streptozotocin-induced depression-like behavior, oxidative stress, and neuroinflammation in mice. MFSeI (10 mg/kg) was administered intragastrically (i.g.) 24 h after...
Source: Brain Research Bulletin - May 26, 2020 Category: Neurology Authors: Bampi SR, Casaril AM, Fronza MG, Domingues M, Vieira B, Begnini KR, Seixas FK, Collares TV, Lenardão EJ, Savegnago L Tags: Brain Res Bull Source Type: research

lncRNA Mtss1 promotes inflammatory responses and secondary brain injury after intracerebral hemorrhage by targeting miR-709 in mice.
Abstract Secondary brain injuries following intracerebral hemorrhage (ICH) are mediated by inflammatory pathway activation. The present study aimed to characterize long noncoding RNAs (lncRNAs) that are differentially expressed in cerebral tissues during ICH pathogenesis and to investigate their pathogenic functions. An ICH mouse model established by collagenase injection was used to obtain differentially expressed lncRNAs for deep sequencing. A cellular inflammation model was established by treating mouse microglia with lipopolysaccharide. Expression of lncRNA and miRNA was assessed by quantitative RT-PCR, and pr...
Source: Brain Research Bulletin - May 19, 2020 Category: Neurology Authors: Chen JX, Wang YP, Zhang X, Li GX, Zheng K, Duan CZ Tags: Brain Res Bull Source Type: research

Neuroprotective Effect of Low-intensity Transcranial Ultrasound Stimulation in Endothelin-1-Induced Middle Cerebral Artery Occlusion in rats.
CONCLUSIONS: Imaging, behavioral, and histological results suggested that LITUS stimulation after an ischemic stroke produced significant neuroprotective effects. PMID: 32439337 [PubMed - as supplied by publisher] (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - May 18, 2020 Category: Neurology Authors: Wu S, Zheng T, Du J, Yuan Y, Shi Q, Wang Z, Liu D, Liu J, Wang X, Liu L Tags: Brain Res Bull Source Type: research

Midazolam contributes to neuroprotection against hypoxia/reoxygenation-induced brain injury in neonatal rats via regulation of EAAT2.
Abstract Excitotoxicity is one of the main mechanisms related to hypoxia/reoxygenation (H/R) injury. Excitatory amino acid transporter (EAAT)2 mainly distributes on astrocytes and plays an important role on glutamate reuptake and glutamate homeostasis. Midazolam has a neuroprotective effect in some neuropathological conditions. The present study aimed to detect the role of EAAT2 in the neuroprotective effect of midazolam in neonatal rat brain subjected to H/R. Pretreatment with midazolam reversed H/R-induced apoptosis and downregulation of EAAT2 mRNA and protein expression in the hippocampus. Pretreatment with dih...
Source: Brain Research Bulletin - May 17, 2020 Category: Neurology Authors: Tang Z, Yang F, Dong Y, Ma C, Sun S, Shan Y, Zhang Y, Liu H Tags: Brain Res Bull Source Type: research

Pilocarpine-induced status epilepticus reduces chemosensory control of breathing.
Abstract One of the possible causes of death in epilepsy is breathing disorders, especially apneas, which lead to an increase in CO2 levels (hypercapnia) and/or a decrease in O2 levels in arterial blood (hypoxemia). The respiratory neurons located in the ventral brainstem respiratory column are the main groups responsible for controlling breathing. Recent data from our group demonstrated respiratory changes in two experimental models of epilepsy, i.e audiogenic epilepsy, and amygdala rapid kindling. Here, we aimed to evaluate respiratory changes in the classic model of temporal lobe epilepsy induced by intra-hippo...
Source: Brain Research Bulletin - May 17, 2020 Category: Neurology Authors: Maia OAC, Malheiros-Lima MR, Oliveira MA, Castro CL, Moriya HT, Tavares-de-Lima W, Takakura AC, Moreira TS Tags: Brain Res Bull Source Type: research

The therapeutic effects of craniotomy versus endoscopic-assisted trepanation drainage for isolated chronic subdural haematoma (ICSH): A single-centre long-term retrospective comparison study.
CONCLUSIONS: Compared with craniotomy, EATD is a more effective and safer method for the treatment of ICSH. PMID: 32428625 [PubMed - as supplied by publisher] (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - May 16, 2020 Category: Neurology Authors: Zhang J, Chen J Tags: Brain Res Bull Source Type: research

Effect of electroacupuncture on the expression of P2  × 4, GABAA γ 2 and long-term potentiation in spinal cord of rats with neuropathic pain.
Effect of electroacupuncture on the expression of P2 × 4, GABAA γ 2 and long-term potentiation in spinal cord of rats with neuropathic pain. Brain Res Bull. 2020 May 16;: Authors: Zheng Y, Zhou Y, Wu Q, Yue J, Ying X, Li S, Lou X, Yang G, Tu W, Zhou K, Jiang S Abstract OBJECTIVE: To observe the impacts of electroacupuncture (EA) stimulation at "Zusanli and Kunlun Points" on spinal dorsal horn microglia activation in L5 spinal nerve ligation (SNL) rats and BNDF, P2 × 4 and GABAAγ2, and the changes in spinal dorsal horn synaptic plasticity in...
Source: Brain Research Bulletin - May 16, 2020 Category: Neurology Authors: Zheng Y, Zhou Y, Wu Q, Yue J, Ying X, Li S, Lou X, Yang G, Tu W, Zhou K, Jiang S Tags: Brain Res Bull Source Type: research

Transient Gain of Function of Cannabinoid CB1 Receptors in the Control of Frontocortical Glucose Consumption in a Rat Model of Type-1 Diabetes.
We report that frontocortical CB1R protein density was biphasically altered in the first month of T1D, which was accompanied with a reduction of resting glucose uptake ex vivo in acute frontocortical slices that was normalized after eight weeks in T1D. This early reduction of glucose uptake in slices was also restored by ex vivo treatment with both the non-selective CB1R agonists, WIN55212-2 (500 nM) and the CB1R-selective agonist, ACEA (3 µM) while it was exacerbated by the CB1R-selective antagonist, O-2050 (500 nM). These results suggest a gain-of-function for the cerebrocortical CB1Rs in the control ...
Source: Brain Research Bulletin - May 16, 2020 Category: Neurology Authors: Pedro JR, Moura LIF, Valério-Fernandes Â, Baptista FI, Gaspar JM, Pinheiro BS, Lemos C, Kaufmann FN, Morgado C, Silva-Santos CSD, Tavares I, Ferreira SG, Carvalho E, Ambrósio AF, Cunha RA, Duarte JMN, Köfalvi A Tags: Brain Res Bull Source Type: research

Regulation of SPARC Family Proteins in Disorders of the Central Nervous System.
Abstract SPARC (secreted protein acidic and rich in cysteine) family of proteins is a class of protein involved in tissue development and repair by regulating cell adhesion, proliferation, metastasis, and growth factor signaling to affect the extracellular matrix (ECM) and interactions between cells. Although being highly valued in non-nerve tissues, studies in both cell and animal models have been revealed that SPARC family proteins may also continue to play a vital role in central nervous system (CNS) diseases and development. These SPARC family proteins are widely expressed in the CNS of normal people, and sign...
Source: Brain Research Bulletin - May 14, 2020 Category: Neurology Authors: Chen S, Zou Q, Wang K, Chen Y, Kuang X, Wu W, Guo M, Cai Y, Li Q Tags: Brain Res Bull Source Type: research

Corilagin ameliorates sleep deprivation-induced memory impairments by inhibiting NOX2 and activating Nrf2.
Abstract Sleep deprivation (SD) can induce cognitive and memory impairments. This impairment is in part due to oxidative stress damage in the hippocampus region of the brain. Corilagin (CL), a polyphenol belonging to the tannin family and extracted from Terminalia chebula and Phyllanthus emblica, shows strong antioxidant and neuroprotective effects. NF-E2-related factor (Nrf2)/heme oxygenase-1 (HO-1) and NADPH oxidase (NOX) are critical targets involved in cellular defense mechanisms against oxidative injury. Thus, we hypothesized that CL could be a preventive treatment for SD-induced memory impairments by inhibit...
Source: Brain Research Bulletin - May 7, 2020 Category: Neurology Authors: Wang W, Yang L, Liu T, Ma Y, Huang S, He M, Wang J, Wen A, Ding Y Tags: Brain Res Bull Source Type: research

Neuroprotective role of alendronate against APP processing and neuroinflammation in mice fed a high fat diet.
Abstract Obesity and consumption of diet rich in fat are known to contribute to the development of Alzheimer's disease (AD) which is a complex and multifactorial neurodegenerative disease and a leading cause of mortality with unmet medical needs. Hypercholesterolemia was discovered to increase neuropathological changes alongwith cognitive decline in AD mouse models but still the underlying mechanism is elusive. Furthermore, isoprenoids, the crucial products of Mevalonate-pathway produced by the action of farnesyl pyrophosphate synthase (FPPS) enzyme, are also demonstrated to play a key role in AD. Nevertheless, bi...
Source: Brain Research Bulletin - May 7, 2020 Category: Neurology Authors: Zameer S, Alam M, Hussain S, Vohora D, Ali J, Akhtar M Tags: Brain Res Bull Source Type: research

TGF β1 alleviates axonal injury by regulating microglia/macrophages alternative activation in traumatic brain injury.
TGFβ1 alleviates axonal injury by regulating microglia/macrophages alternative activation in traumatic brain injury. Brain Res Bull. 2020 May 07;: Authors: Zhao J, Wang B, Wu X, Yang Z, Huang T, Guo X, Guo D, Liu Z, Song J Abstract Traumatic brain injury (TBI) causes substantial mortality and long-term disability worldwide. TGFβ1 is a unique molecular and functional signature in microglia, but the role of TGFβ1 in TBI is not clear. The purpose of this study was to investigate the role of TGFβ1 in TBI. The weight dropping device was used to establish TBI model of rats. Hematoxylin e...
Source: Brain Research Bulletin - May 7, 2020 Category: Neurology Authors: Zhao J, Wang B, Wu X, Yang Z, Huang T, Guo X, Guo D, Liu Z, Song J Tags: Brain Res Bull Source Type: research

Comprehensive Circular RNA Profiling Reveals that hsa_circ_0001368 is Involved in Growth Hormone-secreting Pituitary Adenoma Development.
In conclusion, our study identified a wealth of candidate circRNAs involved in GHPA and proposed that hsa_circ_0001368 may represent a novel potential biomarker and therapeutic target of GHPA. PMID: 32389802 [PubMed - as supplied by publisher] (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - May 7, 2020 Category: Neurology Authors: Du Q, Zhang W, Feng Q, Hao B, Cheng C, Cheng Y, Li Y, Fan X, Chen Z Tags: Brain Res Bull Source Type: research

GPR17 Plays a Role in Ischemia-induced Endogenous Repair of Immature Neonatal Cerebral White Matter.
This study tried to explore the expression phase and site of GPR17, and to investigate the effect of silencing GPR17 on endogenous repair mechanism of immature white matter with PVL. Ischemic PVL in vivo results showed that GPR17 gene and protein expression increased more in the PVL than in the sham group at 12h to 24h and 72h to 7 days after PVL. NG2+/GPR17+progenitor cells at 48h to 96h and O4+/GPR17+precursor cells at 72h to 7d were also significantly increased in the PVL compared to the sham groups. Results in vitro showed that oxygen-glucose deprivation (OGD) also induced more GPR17 gene and protein expression than co...
Source: Brain Research Bulletin - May 5, 2020 Category: Neurology Authors: Feng-Xia M, Hui-Jin C, Long-Hua Q, Jeffrey SB Tags: Brain Res Bull Source Type: research

Environmental enrichment enhances post-ischemic cerebral blood flow and functional hyperemia in the ipsilesional somatosensory cortex.
This study aimed to investigate the effect of environmental enrichment treatment on post-ischemic cerebral blood flow and functional hyperemia in the ipsilesional primary somatosensory cortex of rats. With laser speckle imaging, we were able to monitor the resting cerebral blood flow alteration in the middle cerebral artery occlusion model. Both 3- and 28-day post-ischemic infarct volumes were then examined with triphenyltetrazolium chloride and cresyl violet staining, respectively. We found that an exposure to environmental enrichment was associated with higher post-ischemic cerebral blood flow and less brain tissue loss ...
Source: Brain Research Bulletin - May 5, 2020 Category: Neurology Authors: Xie H, Zhang Q, Zhou N, Li C, Yu K, Liu G, Wu J, Jiang C, Hu R, Wu Y Tags: Brain Res Bull Source Type: research

Nicotinamide mononucleotide administration after sever hypoglycemia improves neuronal survival and cognitive function in rats.
Abstract Hypoglycemia-induced brain injury is a potential complication of insulin therapy in diabetic patients. Severe hypoglycemia triggers a cascade of events in vulnerable neurons that may lead to neuronal death and cognitive impairment even after glucose normalization. Oxidative stress and the activation of poly (ADP-ribose) polymerase-1 (PARP-1) are key events in this cascade. The production of reactive oxygen species (ROS) induces DNA damage and the consequent PARP-1 activation, which depletes NAD+ and ATP, resulting in brain injury. One of the key precursors of NAD+ is nicotinamide mononucleotide (NMN), whi...
Source: Brain Research Bulletin - May 4, 2020 Category: Neurology Authors: Wang X, Hu X, Zhang L, Xu X, Sakurai T Tags: Brain Res Bull Source Type: research

miR-18b attenuates cerebral ischemia/reperfusion injury through regulation of ANXA3 and PI3K/Akt signaling pathway.
In conclusion, these data indicate that miR-18b protects against cerebral I/R injury by inhibiting ANXA3 and activating PI3K/Akt pathway, which provides a promising therapeutic target for ischemic stroke therapy. PMID: 32380186 [PubMed - as supplied by publisher] (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - May 4, 2020 Category: Neurology Authors: Min XL, He M, Shi Y, Xie L, Ma XJ, Cao Y Tags: Brain Res Bull Source Type: research

Impairment of learning and memory induced by perinatal exposure to BPA is associated with ER α-mediated alterations of synaptic plasticity and PKC/ERK/CREB signaling pathway in offspring rats.
Impairment of learning and memory induced by perinatal exposure to BPA is associated with ERα-mediated alterations of synaptic plasticity and PKC/ERK/CREB signaling pathway in offspring rats. Brain Res Bull. 2020 May 04;: Authors: Wu D, Wu F, Lin R, Meng Y, Wei W, Sun Q, Jia L Abstract The effect of bisphenol A (BPA) on learning and memory has attracted much attention recently, but its underlying mechanism remains unclear. We aimed to investigate whether the impairment of learning and memory induced by perinatal exposure to BPA was associated with the hippocampal estrogen receptor α (ER&al...
Source: Brain Research Bulletin - May 4, 2020 Category: Neurology Authors: Wu D, Wu F, Lin R, Meng Y, Wei W, Sun Q, Jia L Tags: Brain Res Bull Source Type: research

WBSCR22 confers cell survival and predicts poor prognosis in glioma.
Abstract Human WBSCR22 is involved in cancer proliferation, invasion and metastasis; however, its function in glioma remains unexplored. In our research, we aimed to investigate the role of WBSCR22 in the development of glioma and its possible molecular mechanisms. Using bioinformatic analysis of public datasets, we determined that WBSCR22 overexpression in glioma specimens was correlated with an unfavorable patient prognosis. Our results revealed that WBSCR22 was highly expressed in glioma cell lines. The loss of WBSCR22 inhibited the growth, invasion and migration of glioma cells, while WBSCR22 overexpression pr...
Source: Brain Research Bulletin - May 4, 2020 Category: Neurology Authors: Chi Y, Liang Z, Guo Y, Chen D, Lu L, Lin J, Qiu S, Wang X, Qiu E, Lin F, Chen J, Luo S, Zheng D, Xu X Tags: Brain Res Bull Source Type: research

Epilepsy and Alzheimer's Disease: potential mechanisms for an association.
Abstract Alzheimer's Disease (AD) and epilepsy are common neurological diseases. The prevalence of epilepsy in AD patients is higher than in healthy subjects, but identifying the reasons for this association, the characteristics of seizures in AD, and the implications for patient prognosis and treatment is challenging. The present review provides first of all an overview of the main clinical aspects of AD and epilepsy, of their reciprocal relationship, and of the challenges that identifying seizures in AD patients presents. Limitations of clinical studies addressing this topic are discussed, including their mostly...
Source: Brain Research Bulletin - May 4, 2020 Category: Neurology Authors: Giorgi FS, Saccaro LF, Busceti CL, Biagioni F, Fornai F Tags: Brain Res Bull Source Type: research