Sleep deprivation changes frequency-specific functional organization of the resting human brain
In this study, thirty-seven healthy male subjects underwent resting-state fMRI during rested wakefulness (RW) and after 36hours of SD, and we examined frequency-specific spectral connection changes (0.01-0.08Hz, interval = 0.01Hz) caused by SD. First, we conducted a multivariate pattern analysis combining linear SVM classifiers with a robust feature selection algorithm, and the results revealed that accuracies of 74.29%-84.29% could be achieved in the classification between RW and SD states in leave-one-out cross-validation at different frequency bands, moreover, the spectral connection at the lowest and highest frequency ...
Source: Brain Research Bulletin - March 17, 2024 Category: Neurology Authors: Zhiguo Luo Erwei Yin Ye Yan Shaokai Zhao Liang Xie Hui Shen Ling-Li Zeng Lubin Wang Dewen Hu Source Type: research

Inhibition of lysyl oxidase by pharmacological intervention and genetic manipulation alleviates epilepsy-associated cognitive disorder
Brain Res Bull. 2024 Mar 15:110928. doi: 10.1016/j.brainresbull.2024.110928. Online ahead of print.ABSTRACTEpilepsy-associated cognitive disorder (ECD), a prevalent comorbidity in epilepsy patients, has so far uncharacterized etiological origins. Our prior work revealed that lysyl oxidase (Lox) acted as a novel contributor of ferroptosis, a recently discovered cell death mode in the regulation of brain function. However, the role of Lox-mediated ferroptosis in ECD remains unknown. ECD mouse model was established 2 months later following a single injection of kainic acid (KA) for. After chronic treatment with KA, mice were ...
Source: Brain Research Bulletin - March 17, 2024 Category: Neurology Authors: Kang-Ni Chen Qi-Lin Peng Dan-Feng Cao Zhao-Jun Wang Kai Zhang Xin-Yu Zhou Dong-Yu Min Bo-Ting Zhou Xiao-Yuan Mao Source Type: research

Serum S100B Protein and White Matter Changes in Schizophrenia before and after Medication
Brain Res Bull. 2024 Mar 12:110927. doi: 10.1016/j.brainresbull.2024.110927. Online ahead of print.ABSTRACTSchizophrenia patients have abnormalities in white matter (WM) integrity in brain regions. S100B has been shown to be a marker protein for glial cells. The atypical antipsychotics have neuroprotective effects on the brain. It is not clear whether antipsychotics can induce S100B changes and improve symptoms by protecting oligodendrocytes. To investigate WM and S100B changes and associations and determine the effect of quetiapine on WM and S100B in schizophrenia patients, we determined serum S100B levels with solid phas...
Source: Brain Research Bulletin - March 14, 2024 Category: Neurology Authors: Han Shi Yan Zhang YongFeng Yang HaiSan Zhang WenQiang Li ZhaoXi Zhong LuXian Lv Source Type: research

Corrigendum to "RNAi-mediated knockdown of DJ-1 leads to mitochondrial dysfunction via Akt/GSK-3 ß and JNK signaling pathways in dopaminergic neuron-like cells" [Brain Res. Bull. 146 (2019) 228-236]
Brain Res Bull. 2024 Mar 14:110926. doi: 10.1016/j.brainresbull.2024.110926. Online ahead of print.NO ABSTRACTPMID:38485616 | DOI:10.1016/j.brainresbull.2024.110926 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - March 14, 2024 Category: Neurology Authors: Xiao-Ling Zhang Zhen-Zhen Wang Qian-Hang Shao Zhao Zhang Lin Li Zhen-Yu Guo Hong-Mei Sun Yi Zhang Nai-Hong Chen Source Type: research

Serum S100B Protein and White Matter Changes in Schizophrenia before and after Medication
Brain Res Bull. 2024 Mar 12:110927. doi: 10.1016/j.brainresbull.2024.110927. Online ahead of print.ABSTRACTSchizophrenia patients have abnormalities in white matter (WM) integrity in brain regions. S100B has been shown to be a marker protein for glial cells. The atypical antipsychotics have neuroprotective effects on the brain. It is not clear whether antipsychotics can induce S100B changes and improve symptoms by protecting oligodendrocytes. To investigate WM and S100B changes and associations and determine the effect of quetiapine on WM and S100B in schizophrenia patients, we determined serum S100B levels with solid phas...
Source: Brain Research Bulletin - March 14, 2024 Category: Neurology Authors: Han Shi Yan Zhang YongFeng Yang HaiSan Zhang WenQiang Li ZhaoXi Zhong LuXian Lv Source Type: research

Corrigendum to "RNAi-mediated knockdown of DJ-1 leads to mitochondrial dysfunction via Akt/GSK-3 ß and JNK signaling pathways in dopaminergic neuron-like cells" [Brain Res. Bull. 146 (2019) 228-236]
Brain Res Bull. 2024 Mar 14:110926. doi: 10.1016/j.brainresbull.2024.110926. Online ahead of print.NO ABSTRACTPMID:38485616 | DOI:10.1016/j.brainresbull.2024.110926 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - March 14, 2024 Category: Neurology Authors: Xiao-Ling Zhang Zhen-Zhen Wang Qian-Hang Shao Zhao Zhang Lin Li Zhen-Yu Guo Hong-Mei Sun Yi Zhang Nai-Hong Chen Source Type: research

Corrigendum to "RNAi-mediated knockdown of DJ-1 leads to mitochondrial dysfunction via Akt/GSK-3 ß and JNK signaling pathways in dopaminergic neuron-like cells" [Brain Res. Bull. 146 (2019) 228-236]
Brain Res Bull. 2024 Mar 14:110926. doi: 10.1016/j.brainresbull.2024.110926. Online ahead of print.NO ABSTRACTPMID:38485616 | DOI:10.1016/j.brainresbull.2024.110926 (Source: Brain Research Bulletin)
Source: Brain Research Bulletin - March 14, 2024 Category: Neurology Authors: Xiao-Ling Zhang Zhen-Zhen Wang Qian-Hang Shao Zhao Zhang Lin Li Zhen-Yu Guo Hong-Mei Sun Yi Zhang Nai-Hong Chen Source Type: research

Serum S100B Protein and White Matter Changes in Schizophrenia before and after Medication
Brain Res Bull. 2024 Mar 12:110927. doi: 10.1016/j.brainresbull.2024.110927. Online ahead of print.ABSTRACTSchizophrenia patients have abnormalities in white matter (WM) integrity in brain regions. S100B has been shown to be a marker protein for glial cells. The atypical antipsychotics have neuroprotective effects on the brain. It is not clear whether antipsychotics can induce S100B changes and improve symptoms by protecting oligodendrocytes. To investigate WM and S100B changes and associations and determine the effect of quetiapine on WM and S100B in schizophrenia patients, we determined serum S100B levels with solid phas...
Source: Brain Research Bulletin - March 14, 2024 Category: Neurology Authors: Han Shi Yan Zhang YongFeng Yang HaiSan Zhang WenQiang Li ZhaoXi Zhong LuXian Lv Source Type: research

The Role of Attention in Immersion: The Two-Competitor Model
Brain Res Bull. 2024 Mar 8:110923. doi: 10.1016/j.brainresbull.2024.110923. Online ahead of print.ABSTRACTCurrently, we face an exponentially increasing interest in immersion, espe- cially sensory-driven immersion, mainly due to the rapid development of ideas and business models centered around a digital virtual universe as well as the increasing availability of affordable immersive technologies for education, com- munication, and entertainment. However, a clear definition of 'immersion', in terms of established neurocognitive concepts and measurable properties, remains elusive, slowing research on the human side of immers...
Source: Brain Research Bulletin - March 10, 2024 Category: Neurology Authors: Daniel J Strauss Alexander L Francis Jonas Vibell Farah I Corona-Strauss Source Type: research

The Role of Attention in Immersion: The Two-Competitor Model
Brain Res Bull. 2024 Mar 8:110923. doi: 10.1016/j.brainresbull.2024.110923. Online ahead of print.ABSTRACTCurrently, we face an exponentially increasing interest in immersion, espe- cially sensory-driven immersion, mainly due to the rapid development of ideas and business models centered around a digital virtual universe as well as the increasing availability of affordable immersive technologies for education, com- munication, and entertainment. However, a clear definition of 'immersion', in terms of established neurocognitive concepts and measurable properties, remains elusive, slowing research on the human side of immers...
Source: Brain Research Bulletin - March 10, 2024 Category: Neurology Authors: Daniel J Strauss Alexander L Francis Jonas Vibell Farah I Corona-Strauss Source Type: research

The Role of Attention in Immersion: The Two-Competitor Model
Brain Res Bull. 2024 Mar 8:110923. doi: 10.1016/j.brainresbull.2024.110923. Online ahead of print.ABSTRACTCurrently, we face an exponentially increasing interest in immersion, espe- cially sensory-driven immersion, mainly due to the rapid development of ideas and business models centered around a digital virtual universe as well as the increasing availability of affordable immersive technologies for education, com- munication, and entertainment. However, a clear definition of 'immersion', in terms of established neurocognitive concepts and measurable properties, remains elusive, slowing research on the human side of immers...
Source: Brain Research Bulletin - March 10, 2024 Category: Neurology Authors: Daniel J Strauss Alexander L Francis Jonas Vibell Farah I Corona-Strauss Source Type: research

Mechanisms and protective measures for radiation-induced brachial plexus nerve injury
Brain Res Bull. 2024 Mar 7:110924. doi: 10.1016/j.brainresbull.2024.110924. Online ahead of print.ABSTRACTRadiation therapy is a common treatment modality for patients with malignant tumors of the head and neck, chest and axilla. However, radiotherapy inevitably causes damage to normal tissues at the irradiated site, among which damage to the brachial plexus nerve(BP) is a serious adverse effect in patients receiving radiation therapy in the scapular or axillary regions, with clinical manifestations including abnormal sensation, neuropathic pain, and dyskinesia, etc. These adverse effects seriously reduce the living qualit...
Source: Brain Research Bulletin - March 9, 2024 Category: Neurology Authors: Jia Ying Wei Li Xin Ma Wen Tong Liu L I Hua Dong Xue Hou Xue Ying Bao Wei Hou Source Type: research

Mechanisms and protective measures for radiation-induced brachial plexus nerve injury
Brain Res Bull. 2024 Mar 7:110924. doi: 10.1016/j.brainresbull.2024.110924. Online ahead of print.ABSTRACTRadiation therapy is a common treatment modality for patients with malignant tumors of the head and neck, chest and axilla. However, radiotherapy inevitably causes damage to normal tissues at the irradiated site, among which damage to the brachial plexus nerve(BP) is a serious adverse effect in patients receiving radiation therapy in the scapular or axillary regions, with clinical manifestations including abnormal sensation, neuropathic pain, and dyskinesia, etc. These adverse effects seriously reduce the living qualit...
Source: Brain Research Bulletin - March 9, 2024 Category: Neurology Authors: Jia Ying Wei Li Xin Ma Wen Tong Liu L I Hua Dong Xue Hou Xue Ying Bao Wei Hou Source Type: research

Targeting blood-brain barrier for sepsis-associated encephalopathy: Regulation of immune cells and ncRNAs
Brain Res Bull. 2024 Mar 6;209:110922. doi: 10.1016/j.brainresbull.2024.110922. Online ahead of print.ABSTRACTSepsis causes significant morbidity and mortality worldwide, most surviving patients show acute or chronic mental disorders, which are known as sepsis-associated encephalopathy (SAE). SAE involves many pathological processes, including the blood-brain barrier (BBB) damage. The BBB is located at the interface between the central nervous system and the surrounding environment, which protects the central nervous system (CNS) from the invasion of exogenous molecules, harmful substances or microorganisms in the blood. R...
Source: Brain Research Bulletin - March 8, 2024 Category: Neurology Authors: Mi Tian Yunliang Zhan Jinyuan Cao Jinqi Gao Jie Sun Li Zhang Source Type: research

Targeting blood-brain barrier for sepsis-associated encephalopathy: Regulation of immune cells and ncRNAs
Brain Res Bull. 2024 Mar 6;209:110922. doi: 10.1016/j.brainresbull.2024.110922. Online ahead of print.ABSTRACTSepsis causes significant morbidity and mortality worldwide, most surviving patients show acute or chronic mental disorders, which are known as sepsis-associated encephalopathy (SAE). SAE involves many pathological processes, including the blood-brain barrier (BBB) damage. The BBB is located at the interface between the central nervous system and the surrounding environment, which protects the central nervous system (CNS) from the invasion of exogenous molecules, harmful substances or microorganisms in the blood. R...
Source: Brain Research Bulletin - March 8, 2024 Category: Neurology Authors: Mi Tian Yunliang Zhan Jinyuan Cao Jinqi Gao Jie Sun Li Zhang Source Type: research