Knockdown of lncRNA NEAT1 suppresses streptococcus pneumoniae-induced ferroptosis in alveolar epithelial cells by regulating the Nrf2-GPX4 pathway
CONCLUSIONS: LncRNA NEAT1 knockdown suppressed SP-induced HPAEpiC ferroptosis by activating Nrf2-GPX4 pathway, thereby alleviating cell injury and inflammatory response.PMID:38556062 | DOI:10.1016/j.toxicon.2024.107705 (Source: Toxicon)
Source: Toxicon - March 31, 2024 Category: Toxicology Authors: Lin Xu Lu Zhang Yang Xiang Xiangyan Zhang Source Type: research
The decreased interface tension increased the transmembrane transport of soy hull polysaccharide-derived SCFAs in the Caco-2 cells
This study lays the theoretical foundation for understanding the structure-activity relationship of soy hull polysaccharides in the intestine.PMID:38556231 | DOI:10.1016/j.ijbiomac.2024.131261 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - March 31, 2024 Category: Biochemistry Authors: Li Li Mingjie Xia Lina Yang Yutang He He Liu Mengxi Xie Miao Yu Source Type: research
USP7 interacts with and destabilizes oncoprotein SET
Biochem Biophys Res Commun. 2024 Mar 27;709:149818. doi: 10.1016/j.bbrc.2024.149818. Online ahead of print.ABSTRACTOncoprotein SE translocation (SET) is frequently overexpressed in different types of tumors and correlated with poor prognosis of cancer patients. Targeting SET has been considered a promising strategy for cancer intervention. However, the mechanisms by which SET is regulated under cellular conditions are largely unknown. Here, by performing a tandem affinity purification-mass spectrometry (TAP-MS), we identify that the ubiquitin-specific protease 7 (USP7) forms a stable protein complex with SET in cancer cell...
Source: Biochemical and Biophysical Research communications - March 31, 2024 Category: Biochemistry Authors: Jianyuan Chen Zishan Jiao Yajing Liu Meng Zhang Donglai Wang Source Type: research
Chrysin inhibits ferroptosis of cerebral ischemia/reperfusion injury via regulating HIF-1 α/CP loop
Biomed Pharmacother. 2024 Mar 30;174:116500. doi: 10.1016/j.biopha.2024.116500. Online ahead of print.ABSTRACTChrysin is a natural flavonoid with powerful neuroprotective capacity. Cerebral ischemia/reperfusion injury (CIRI) is associated with oxidative stress and ferroptosis. Hypoxia-inducible factor 1α (HIF-1α) and ceruloplasmin (CP) are the critical targets for oxidation reactions and iron transport. But the regulatory mechanism between them is still unclear. Transient middle cerebral artery occlusion (tMCAO) model in rats and oxygen and glucose deprivation/re-oxygenation (OGD/R) model in PC12 cells were applied. Path...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 31, 2024 Category: Drugs & Pharmacology Authors: Jinfeng Shang Jiakang Jiao Jingyi Wang Mingxue Yan Qiannan Li Lizha Shabuerjiang Guijinfeng Huang Qi Song Yinlian Wen Xiaolu Zhang Kai Wu Yiran Cui Xin Liu Source Type: research
Integrated In-Silico and In Vitro analysis to Decipher the contribution of bisphenol-A in cervical cancer
Toxicology. 2024 Mar 29;504:153791. doi: 10.1016/j.tox.2024.153791. Online ahead of print.ABSTRACTBisphenol A (BPA) is a synthetic chemical widely used as a monomer for producing polycarbonate plastics. The present investigation employed an in-silico approach to identify BPA-responsive genes and comprehend the biological functions affected using in vitro studies. A Comparative Toxicogenomics Database search identified 29 BPA-responsive genes in cervical cancer (CC). Twenty-nine genes were screened using published datasets, and thirteen of those showed differential expression between normal and CC samples. Protein-Protein I...
Source: Toxicology - March 31, 2024 Category: Toxicology Authors: Nadeem Ghani Khan Divya Adiga Padmalatha Satwadi Rai Shama Prasada Kabekkodu Source Type: research
