Noradrenaline enhances Na ‐K ATPase subunit expression by HuR‐induced mRNA stabilization and their transportation to the cell surface through PLC and PKC mediated pathway: Implications with REMS‐loss associated disorders
Rapid eye movement sleep deprivation associated elevated noradrenaline (NA) increases nucleus-to-cytoplasmic translocation of HuR. The latter then decreases degradation of the Na-K ATPase mRNA, resulting in stability of its mRNA, which in turn increased its translation without increasing the transcription. The increased Na-K ATPase subunit are then translocated to the neuronal membrane. Our findings not only explain a fundamental molecular mechanism of Na-K ATPase subunit expression, but it may also be exploited to ameliorate REMS-loss associated symptoms and disorders. AbstractRapid eye movement sleep (REMS) maintains bra...
Source: Journal of Neurochemistry - April 27, 2024 Category: Neuroscience Authors: Manjeet Kaur,
Rachna Mehta,
Rohini Muthuswami,
Birendra Nath Mallick Tags: ORIGINAL ARTICLE Source Type: research
Genes, Vol. 15, Pages 558: Genetic Mechanisms Driving Uterine Leiomyoma Pathobiology, Epidemiology, and Treatment
Borahay
Uterine leiomyomas (ULs) are the most common benign tumor of the uterus. They can be associated with symptoms including abnormal uterine bleeding, pelvic pain, urinary frequency, and pregnancy complications. Despite the high prevalence of UL, its underlying pathophysiology mechanisms have historically been poorly understood. Several mechanisms of pathogenesis have been suggested, implicating various genes, growth factors, cytokines, chemokines, and microRNA aberrations. The purpose of this study is to summarize the current research on the relationship of genetics with UL. Specifically, we performed a literature...
Source: Genes - April 27, 2024 Category: Genetics & Stem Cells Authors: Malini S. Ramaiyer Eslam Saad Irem Kurt Mostafa A. Borahay Tags: Review Source Type: research
Roles of AhR/CYP1s Signal Pathway Mediated ROS Production in Uremic Cardiomyopathy
CONCLUSION: This study provides evidence that the AhR/CYP1s pathway is activated in UCM rats, and this activation is correlated with the uremic toxin IS. In vitro studies indicate that IS can stimulate the AhR translocation in cardiomyocyte, triggering to the production of intracellular ROS via CYP1s. This process leads to prolonged oxidative stress stimulation and thus contributes to the progression of uremic toxin-mediated cardiomyopathy.PMID:38670245 | DOI:10.1016/j.toxlet.2024.04.005 (Source: Toxicology Letters)
Source: Toxicology Letters - April 26, 2024 Category: Toxicology Authors: Wei Lu Shi Cheng Jiarui Xu Zilong Xiao Yong Yu Qiwen Xie Yi Fang Ruizhen Chen Bo Shen Yeqing Xie Xiaoqiang Ding Source Type: research
Kahweol Inhibits Pro-Inflammatory Cytokines and Chemokines in Tumor Necrosis Factor- α/Interferon-γ-Stimulated Human Keratinocyte HaCaT Cells
Curr Issues Mol Biol. 2024 Apr 18;46(4):3470-3483. doi: 10.3390/cimb46040218.ABSTRACTAtopic dermatitis (AD), marked by intense itching and eczema-like lesions, is a globally increasing chronic skin inflammation. Kahweol, a diterpene that naturally occurs in coffee beans, boasts anti-inflammatory, antioxidative, and anti-cancer properties. This research explores the anti-inflammatory action of kahweol on HaCaT human keratinocytes stimulated by tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ), focusing on key signal transduction pathways. Our results demonstrate that kahweol markedly reduces the production of IL-...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Ye Jin Kwon Hyun Hee Kwon Jaechan Leem Yoon Young Jang Source Type: research
Sclareol protected against intestinal barrier dysfunction ameliorating Crohn's disease-like colitis via Nrf2/NF-B/MLCK signalling
CONCLUSIONS: SCL improved intestinal barrier dysfunction and alleviated CD-like colitis, possibly through modulation of Nrf2/NF-κB/MLCK signalling. In view of SCL's safety profile, there is hope that it will be useful in the clinic.PMID:38669952 | DOI:10.1016/j.intimp.2024.112140 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 26, 2024 Category: Allergy & Immunology Authors: Lian Wang Xue Song Yueqing Zhou Yongsheng Xia Zi Yang Xiaohua Chen Ruohan Shi Zhijun Geng Xiaofeng Zhang Yueyue Wang Jing Li Jianguo Hu Lugen Zuo Source Type: research
Roles of AhR/CYP1s Signal Pathway Mediated ROS Production in Uremic Cardiomyopathy
CONCLUSION: This study provides evidence that the AhR/CYP1s pathway is activated in UCM rats, and this activation is correlated with the uremic toxin IS. In vitro studies indicate that IS can stimulate the AhR translocation in cardiomyocyte, triggering to the production of intracellular ROS via CYP1s. This process leads to prolonged oxidative stress stimulation and thus contributes to the progression of uremic toxin-mediated cardiomyopathy.PMID:38670245 | DOI:10.1016/j.toxlet.2024.04.005 (Source: Toxicology Letters)
Source: Toxicology Letters - April 26, 2024 Category: Toxicology Authors: Wei Lu Shi Cheng Jiarui Xu Zilong Xiao Yong Yu Qiwen Xie Yi Fang Ruizhen Chen Bo Shen Yeqing Xie Xiaoqiang Ding Source Type: research
Kahweol Inhibits Pro-Inflammatory Cytokines and Chemokines in Tumor Necrosis Factor- α/Interferon-γ-Stimulated Human Keratinocyte HaCaT Cells
Curr Issues Mol Biol. 2024 Apr 18;46(4):3470-3483. doi: 10.3390/cimb46040218.ABSTRACTAtopic dermatitis (AD), marked by intense itching and eczema-like lesions, is a globally increasing chronic skin inflammation. Kahweol, a diterpene that naturally occurs in coffee beans, boasts anti-inflammatory, antioxidative, and anti-cancer properties. This research explores the anti-inflammatory action of kahweol on HaCaT human keratinocytes stimulated by tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ), focusing on key signal transduction pathways. Our results demonstrate that kahweol markedly reduces the production of IL-...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Ye Jin Kwon Hyun Hee Kwon Jaechan Leem Yoon Young Jang Source Type: research
Sclareol protected against intestinal barrier dysfunction ameliorating Crohn's disease-like colitis via Nrf2/NF-B/MLCK signalling
CONCLUSIONS: SCL improved intestinal barrier dysfunction and alleviated CD-like colitis, possibly through modulation of Nrf2/NF-κB/MLCK signalling. In view of SCL's safety profile, there is hope that it will be useful in the clinic.PMID:38669952 | DOI:10.1016/j.intimp.2024.112140 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 26, 2024 Category: Allergy & Immunology Authors: Lian Wang Xue Song Yueqing Zhou Yongsheng Xia Zi Yang Xiaohua Chen Ruohan Shi Zhijun Geng Xiaofeng Zhang Yueyue Wang Jing Li Jianguo Hu Lugen Zuo Source Type: research
Kahweol Inhibits Pro-Inflammatory Cytokines and Chemokines in Tumor Necrosis Factor- α/Interferon-γ-Stimulated Human Keratinocyte HaCaT Cells
Curr Issues Mol Biol. 2024 Apr 18;46(4):3470-3483. doi: 10.3390/cimb46040218.ABSTRACTAtopic dermatitis (AD), marked by intense itching and eczema-like lesions, is a globally increasing chronic skin inflammation. Kahweol, a diterpene that naturally occurs in coffee beans, boasts anti-inflammatory, antioxidative, and anti-cancer properties. This research explores the anti-inflammatory action of kahweol on HaCaT human keratinocytes stimulated by tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ), focusing on key signal transduction pathways. Our results demonstrate that kahweol markedly reduces the production of IL-...
Source: Current Issues in Molecular Biology - April 26, 2024 Category: Molecular Biology Authors: Ye Jin Kwon Hyun Hee Kwon Jaechan Leem Yoon Young Jang Source Type: research
A signaling network map of Lipoxin (LXA4): an anti-inflammatory molecule
In this study, we systematically investigated the intricate network of lipoxin signaling by analyzing the relevant literature. The resulting map comprised 467 molecules categorized as activation/inhibition, enzyme catalysis, gene and protein expression, molecular associations, and translocation events. This map serve s as a valuable resource for understanding the complexity of lipoxin signaling and its impact on various cellular functions. (Source: Inflammation Research)
Source: Inflammation Research - April 26, 2024 Category: Research Source Type: research
Characterization of herpetrione amorphous nanoparticles stabilized by hydroxypropylmethyl cellulose and its absorption mechanism in vitro
In conclusion, the differences in the absorption behavior trends of HPE-ANPs are caused by the difference in particle properties and the form of existence of the drug.PMID:38663711 | DOI:10.1016/j.ijbiomac.2024.131744 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 25, 2024 Category: Biochemistry Authors: Fang Wang Lingyu Hang Bo Dai Fangqin Li Yuwen Zhu Haiqiang Jia Ai Yu Liqiang Wang Yuye Xue Hailong Yuan Source Type: research
KN-93 Promotes HDAC4 Nucleus Translocation to promote fatty acid oxidation in Myocardial Infarction
In conclusion, KN-93 promotes HDAC4 translocation to the nucleus, thereby potentially enhancing fatty acid oxidation by SP1.PMID:38663474 | DOI:10.1016/j.yexcr.2024.114050 (Source: Experimental Cell Research)
Source: Experimental Cell Research - April 25, 2024 Category: Cytology Authors: Jianqiao Zhao Luona Li Xindong Wang Jianping Shen Source Type: research
KN-93 Promotes HDAC4 Nucleus Translocation to promote fatty acid oxidation in Myocardial Infarction
In conclusion, KN-93 promotes HDAC4 translocation to the nucleus, thereby potentially enhancing fatty acid oxidation by SP1.PMID:38663474 | DOI:10.1016/j.yexcr.2024.114050 (Source: Cell Research)
Source: Cell Research - April 25, 2024 Category: Cytology Authors: Jianqiao Zhao Luona Li Xindong Wang Jianping Shen Source Type: research
Aflatoxin B < sub > 1 < /sub > -exposed hepatocyte-derived extracellular vesicles: Initiating hepatic stellate cell-mediated liver fibrosis through a p53-Parkin-dependent mitophagy pathway
This study further revealed that the hepatic fibrogenesis of AFB1 exposure was rescued by genetic intervention with siPARK2 or p53's Pifithrin-α (PFTα) inhibitors. Furthermore, AFB1-EVs-induced HSCs activation was relieved by GW4869 pharmaceutic inhibition of EVs secretion. These results revealed a novel mechanism that AFB1 exposure-induced p53-Parkin signal axis regulated mitophagy-dependent hepatocyte-derived EVs to mediate the mitochondria-trafficking intercellular communication between hepatocytes and HSCs in the local hepatotoxic microenvironment to promote the activated HSCs-associated liver fibrogenesis. Our study...
Source: Ecotoxicology and Environmental Safety - April 25, 2024 Category: Environmental Health Authors: Lei Yang Yun-Lu Gao Shan Jiang Bo Qian Lin Che Jia-Shen Wu Ze-Bang Du Ming-Zhu Wang Yun Yang Yu-Chun Lin Gang Liu Zhong-Ning Lin Source Type: research
Characterization of herpetrione amorphous nanoparticles stabilized by hydroxypropylmethyl cellulose and its absorption mechanism in vitro
In conclusion, the differences in the absorption behavior trends of HPE-ANPs are caused by the difference in particle properties and the form of existence of the drug.PMID:38663711 | DOI:10.1016/j.ijbiomac.2024.131744 (Source: International Journal of Biological Macromolecules)
Source: International Journal of Biological Macromolecules - April 25, 2024 Category: Biochemistry Authors: Fang Wang Lingyu Hang Bo Dai Fangqin Li Yuwen Zhu Haiqiang Jia Yu Ai Liqiang Wang Yuye Xue Hailong Yuan Source Type: research
