The Stress Phenotyping Framework: A multidisciplinary biobehavioral approach for assessing and therapeutically targeting maladaptive stress physiology
Stress. 2024 Jan;27(1):2327333. doi: 10.1080/10253890.2024.2327333. Epub 2024 May 6.ABSTRACTAlthough dysregulated stress biology is becoming increasingly recognized as a key driver of lifelong disparities in chronic disease, we presently have no validated biomarkers of toxic stress physiology; no biological, behavioral, or cognitive treatments specifically focused on normalizing toxic stress processes; and no agreed-upon guidelines for treating stress in the clinic or evaluating the efficacy of interventions that seek to reduce toxic stress and improve human functioning. We address these critical issues by (a) systematical...
Source: Stress - May 7, 2024 Category: Research Authors: Rachel Gilgoff Summer Mengelkoch Jorina Elbers Krista Kotz Arielle Radin Isha Pasumarthi Reanna Murthy Sayantani Sindher Nadine Burke Harris George M Slavich Source Type: research
Differential impact of prenatal PTSD symptoms and preconception trauma exposure on placental < em > NR3C1 < /em > and < em > FKBP5 < /em > methylation
Stress. 2024 Jan;27(1):2321595. doi: 10.1080/10253890.2024.2321595. Epub 2024 Apr 26.ABSTRACTPerinatal stress is associated with altered placental methylation, which plays a critical role in fetal development and infant outcomes. This proof-of-concept pilot study investigated the impact of lifetime trauma exposure and perinatal PTSD symptoms on epigenetic regulation of placenta glucocorticoid signaling genes (NR3C1 and FKBP5). Lifetime trauma exposure and PTSD symptoms during pregnancy were assessed in a racially/ethnically diverse sample of pregnant women (N = 198). Participants were categorized into three groups: (1) No ...
Source: Stress - April 27, 2024 Category: Research Authors: Laura R Stroud Nancy C Jao L G Ward Sharon Y Lee Carmen J Marsit Source Type: research
A mismatch between early and recent life stress predicts better response inhibition, but not cognitive inhibition
Stress. 2024 Jan;27(1):2341626. doi: 10.1080/10253890.2024.2341626. Epub 2024 Apr 22.ABSTRACTA growing body of work has found that a mismatch between early and recent life stress, more than a cumulative influence of stress, contributes to detrimental stress-related health outcomes. To date, however, no work has examined how such a mismatch might relate to stress-related cognitive outcomes. We addressed this gap in the current study by assessing participants' (N = 154, Mage = 18.7, 104 female) early and recent life stress using the same inventory, and subsequently assessing their inhibitory control in a hybrid stop-signal/f...
Source: Stress - April 22, 2024 Category: Research Authors: Grant S Shields Colton L Hunter Source Type: research
Early-age thermal manipulation and supplemental antioxidants on physiological, biochemical and productive performance of broiler chickens in hot-tropical environments
This study evaluated the effects of early-age thermal manipulation (EATC) and supplemental antioxidants on the physiological responses of broilers in a hot tropical environment. A total of 300 day-old Ross broiler chicks were allocated to five thermal and dietary treatments, having 5 replicates of twelve birds each. The treatments were: chicks reared using the conventional method (CC), chicks exposed to early thermal manipulation with a temperature of 38 °C at day 5 with no antioxidant supplementation (TC), TC plus vitamin E at 250 mg/kg of feed (TV), TC plus selenium at 0.5 mg/kg of feed (TS) and the combination of TS an...
Source: Stress - April 17, 2024 Category: Research Authors: Aderanti Ifeoluwa Oni John Adesanya Abiona Adeboye Olusesan Fafiolu Oyegunle Emmanuel Oke Source Type: research
